format-version: 1.2 date: 07:03:2012 18:04 auto-generated-by: NeXO generator 1.0 ontology: NeXO saved-by: janusz [Term] id: NeXO:9160 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.44990676330261 density:0.0476190476190476 bootstrap:0.175349983 cc_score:0.0747659 bp_score:0.0850215 mf_score:0.0 relationship: child_of NeXO:9675 ! CC: | BP: | MF: [Term] id: NeXO:5745 name: CC: | BP: | MF:D-arabinono-1,4-lactone oxidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.36904235 cc_score:0.0 bp_score:0.0283869 mf_score:0.206176 relationship: child_of NeXO:6438 ! CC: | BP: | MF: [Term] id: NeXO:5111 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83545703 cc_score:0.0 bp_score:0.0463779 mf_score:0.0 relationship: child_of NeXO:5194 ! CC: | BP: | MF: [Term] id: NeXO:5988 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07555470083422 density:0.666666666666667 bootstrap:0.86202498 cc_score:0.0 bp_score:0.0435766 mf_score:0.0 relationship: child_of NeXO:5989 ! CC: | BP: | MF: [Term] id: NeXO:5989 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.66669039374998 density:0.333333333333333 bootstrap:0.75906696 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6688 ! CC: | BP: | MF: [Term] id: NeXO:8805 name: CC: DUBm complex | BP: histone deubiquitination | MF:histone H3-K18 acetylation def: "CC_def: A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p. | BP_def: The modification of histones by removal of ubiquitin groups. | MF_def:The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [NeXO-GO:term] namespace: NeXO comment: robustness:4.76396475324141 density:1 bootstrap:0.626760537 cc_score:0.303683 bp_score:0.29624 mf_score:0.21875 relationship: child_of NeXO:9258 ! CC: SAGA complex | BP: protein deubiquitination | MF:histone acetylation relationship: linked_to NeXO:7566 ! CC: | BP: | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:5982 name: CC: GPI-anchor transamidase complex | BP: attachment of GPI anchor to protein | MF:GPI-anchor transamidase activity def: "CC_def: An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. | BP_def: A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. | MF_def:Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [NeXO-GO:term] namespace: NeXO comment: robustness:4.10970881957463 density:1 bootstrap:0.93286819 cc_score:0.526089 bp_score:0.531968 mf_score:0.525138 relationship: child_of NeXO:7217 ! CC: | BP: | MF: relationship: linked_to NeXO:8358 ! CC: | BP: | MF:glucosaminyl-phosphotidylinositol O-acyltransferase activity [Term] id: NeXO:5983 name: CC: | BP: positive regulation of cellular amino acid metabolic process | MF:acetyl-CoA:L-glutamate N-acetyltransferase activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. | MF_def:Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78518694 cc_score:0.0 bp_score:0.204534 mf_score:0.230493 relationship: child_of NeXO:6675 ! CC: | BP: | MF:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [Term] id: NeXO:5981 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.802222156 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6198 ! CC: | BP: heme catabolic process | MF: [Term] id: NeXO:5986 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.09419311303482 density:0.666666666666667 bootstrap:0.87250469 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5987 ! CC: | BP: | MF: [Term] id: NeXO:5987 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51804961705717 density:0.333333333333333 bootstrap:0.67680485 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6164 ! CC: | BP: | MF: [Term] id: NeXO:5984 name: CC: | BP: | MF:superoxide dismutase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [NeXO-GO:term] namespace: NeXO comment: robustness:2.07320857757681 density:0.133333333333333 bootstrap:0.57796038 cc_score:0.0 bp_score:0.0926947 mf_score:0.143614 relationship: child_of NeXO:6727 ! CC: | BP: copper ion transport | MF:sodium ion transmembrane transporter activity [Term] id: NeXO:5985 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54657971 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6595 ! CC: | BP: | MF: [Term] id: NeXO:7517 name: CC: | BP: nuclear mRNA 5'-splice site recognition | MF: def: "CC_def: | BP_def: Recognition of the intron 5'-splice site by components of the assembling spliceosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.50753558868838 density:1 bootstrap:0.561103391 cc_score:0.0 bp_score:0.110889 mf_score:0.0713329 relationship: child_of NeXO:7991 ! CC: | BP: | MF: relationship: linked_to NeXO:8744 ! CC: | BP: | MF: [Term] id: NeXO:7516 name: CC: | BP: cytosine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.533901308 cc_score:0.0 bp_score:0.203691 mf_score:0.0 relationship: child_of NeXO:7674 ! CC: | BP: | MF:borate efflux transmembrane transporter activity [Term] id: NeXO:7515 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.4766299595965 density:1 bootstrap:0.361297701 cc_score:0.0 bp_score:0.0742782 mf_score:0.0673828 relationship: child_of NeXO:7923 ! CC: | BP: | MF: relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:7514 ! CC: | BP: | MF:NADH pyrophosphatase activity relationship: linked_to NeXO:8259 ! CC: | BP: | MF: [Term] id: NeXO:7514 name: CC: | BP: | MF:NADH pyrophosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.4237368727068 density:0.833333333333333 bootstrap:0.412954474 cc_score:0.0 bp_score:0.0185598 mf_score:0.196051 relationship: child_of NeXO:7742 ! CC: | BP: | MF: [Term] id: NeXO:7513 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.28111396158423 density:0.1 bootstrap:0.438464112 cc_score:0.0 bp_score:0.0694144 mf_score:0.0 relationship: child_of NeXO:8996 ! CC: | BP: | MF:copper ion binding [Term] id: NeXO:7512 name: CC: chiasma | BP: | MF: def: "CC_def: A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.456186199 cc_score:0.230719 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8266 ! CC: MutLbeta complex | BP: chiasma assembly | MF:DNA insertion or deletion binding [Term] id: NeXO:7511 name: CC: | BP: | MF:carboxymethylenebutenolidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90690149 cc_score:0.0 bp_score:0.0 mf_score:0.439015 relationship: child_of NeXO:8484 ! CC: | BP: positive regulation of translational elongation | MF: relationship: linked_to NeXO:7961 ! CC: | BP: | MF:diphosphomevalonate decarboxylase activity [Term] id: NeXO:7510 name: CC: | BP: CDP-diacylglycerol metabolic process | MF:CDP-diacylglycerol-serine O-phosphatidyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. | MF_def:Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [NeXO-GO:term] namespace: NeXO comment: robustness:3.78151096559936 density:1 bootstrap:0.78982142 cc_score:0.0921166 bp_score:0.294665 mf_score:0.298381 relationship: child_of NeXO:7819 ! CC: | BP: phosphatidylserine biosynthetic process | MF:phosphatidylethanolamine N-methyltransferase activity [Term] id: NeXO:8694 name: CC: U2 snRNP | BP: | MF: def: "CC_def: A ribonucleoprotein complex that contains small nuclear RNA U2. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.82674600444937 density:1 bootstrap:0.86062698 cc_score:0.314912 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9582 ! CC: U2-type prespliceosome | BP: spliceosome assembly | MF: [Term] id: NeXO:7519 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49491251 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8321 ! CC: | BP: | MF: [Term] id: NeXO:7518 name: CC: | BP: peptidyl-diphthamide biosynthetic process from peptidyl-histidine | MF: def: "CC_def: | BP_def: The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.38616582220608 density:0.9 bootstrap:0.7840511 cc_score:0.0 bp_score:0.523667 mf_score:0.0 relationship: child_of NeXO:7646 ! CC: | BP: peptidyl-histidine modification | MF: [Term] id: NeXO:8802 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.19501403 cc_score:0.0 bp_score:0.0196735 mf_score:0.0 relationship: child_of NeXO:9131 ! CC: | BP: | MF: [Term] id: NeXO:6150 name: CC: glycine cleavage complex | BP: glycine decarboxylation via glycine cleavage system | MF:trichothecene 3-O-acetyltransferase activity def: "CC_def: A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. | BP_def: The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. | MF_def:Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.785977806 cc_score:0.17505 bp_score:0.299406 mf_score:0.440951 relationship: child_of NeXO:6521 ! CC: | BP: negative regulation of transcription elongation from RNA polymerase II promoter | MF:glycine dehydrogenase (decarboxylating) activity [Term] id: NeXO:6151 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2932986754699 density:1 bootstrap:0.87145123 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7497 ! CC: | BP: | MF: [Term] id: NeXO:6152 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49886176 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6417 ! CC: | BP: removal of superoxide radicals | MF:thioredoxin-disulfide reductase activity [Term] id: NeXO:6153 name: CC: | BP: | MF:delta24(24-1) sterol reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96286605910989 density:1 bootstrap:0.63841514 cc_score:0.0 bp_score:0.0 mf_score:0.445624 relationship: child_of NeXO:6800 ! CC: | BP: | MF:squalene synthase activity relationship: linked_to NeXO:7788 ! CC: | BP: | MF:C-4 methylsterol oxidase activity relationship: linked_to NeXO:6711 ! CC: | BP: | MF:C-5 sterol desaturase activity [Term] id: NeXO:6154 name: CC: | BP: | MF:methylglyoxal reductase (NADPH-dependent) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.12179349683688 density:1 bootstrap:0.74598153 cc_score:0.0 bp_score:0.0 mf_score:0.438091 relationship: child_of NeXO:6157 ! CC: | BP: | MF:3-methylbutanol:NAD(P) oxidoreductase activity [Term] id: NeXO:6155 name: CC: | BP: ferric-enterobactin transport | MF:ferric-enterobactin transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of ferric-enterobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.87772909826707 density:1 bootstrap:0.5842352 cc_score:0.0 bp_score:0.440342 mf_score:0.444643 relationship: child_of NeXO:6156 ! CC: | BP: | MF: [Term] id: NeXO:6156 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.00011512901573 density:0.2 bootstrap:0.48337152 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7198 ! CC: | BP: | MF: [Term] id: NeXO:6157 name: CC: | BP: | MF:3-methylbutanol:NAD(P) oxidoreductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [NeXO-GO:term] namespace: NeXO comment: robustness:1.74367521134052 density:0.166666666666667 bootstrap:0.71551779 cc_score:0.0 bp_score:0.0 mf_score:0.206127 relationship: child_of NeXO:6550 ! CC: | BP: | MF:tRNA (m5U54) methyltransferase activity [Term] id: NeXO:6158 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.734011245 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6410 ! CC: chitosan layer of spore wall | BP: chitin catabolic process | MF:chitin deacetylase activity [Term] id: NeXO:6159 name: CC: | BP: propionate catabolic process, 2-methylcitrate cycle | MF:2-methylcitrate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. | MF_def:Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.406537263 cc_score:0.0 bp_score:0.294589 mf_score:0.440425 relationship: child_of NeXO:7823 ! CC: | BP: lysine biosynthetic process via aminoadipic acid | MF:saccharopine dehydrogenase activity [Term] id: NeXO:6796 name: CC: cell tip | BP: negative regulation of ubiquitin-protein ligase activity | MF: def: "CC_def: The region at either end of the longest axis of a cylindrical or elongated cell. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.780428363 cc_score:0.218843 bp_score:0.193999 mf_score:0.0 relationship: child_of NeXO:7400 ! CC: | BP: negative regulation of protein ubiquitination | MF: [Term] id: NeXO:6797 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19921413095463 density:1 bootstrap:0.80141392 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7886 ! CC: | BP: | MF: relationship: linked_to NeXO:9508 ! CC: | BP: | MF:ATP-dependent 3'-5' DNA helicase activity [Term] id: NeXO:6794 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25301840447596 density:0.666666666666667 bootstrap:0.462596581 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7045 ! CC: | BP: | MF: [Term] id: NeXO:6795 name: CC: methionyl glutamyl tRNA synthetase complex | BP: glycerol biosynthetic process | MF:methionine-tRNA ligase activity def: "CC_def: A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers. | BP_def: The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. | MF_def:Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.65608885 cc_score:0.218816 bp_score:0.221715 mf_score:0.292819 relationship: child_of NeXO:7544 ! CC: | BP: methionyl-tRNA aminoacylation | MF: relationship: linked_to NeXO:9955 ! CC: | BP: protein import into nucleus, translocation | MF: [Term] id: NeXO:6793 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7771862 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8161 ! CC: | BP: | MF: relationship: linked_to NeXO:7218 ! CC: | BP: positive regulation of mitochondrial DNA replication | MF: relationship: linked_to NeXO:8172 ! CC: | BP: | MF: relationship: linked_to NeXO:7824 ! CC: | BP: | MF: [Term] id: NeXO:6790 name: CC: | BP: | MF:L-glutamine transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:3.95168746673003 density:1 bootstrap:0.86250845 cc_score:0.0 bp_score:0.0 mf_score:0.177622 relationship: child_of NeXO:8151 ! CC: | BP: | MF: [Term] id: NeXO:6791 name: CC: | BP: | MF:transferase activity, transferring aldehyde or ketonic groups def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.18244217858222 density:0.178571428571429 bootstrap:0.540857527 cc_score:0.0 bp_score:0.0511874 mf_score:0.133544 relationship: child_of NeXO:7058 ! CC: | BP: | MF: [Term] id: NeXO:8808 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91279185269678 density:0.214285714285714 bootstrap:0.36232514 cc_score:0.0 bp_score:0.0974315 mf_score:0.0 relationship: child_of NeXO:9333 ! CC: | BP: osmosensory signaling pathway | MF: [Term] id: NeXO:6298 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.12917091514923 density:0.666666666666667 bootstrap:0.89234236 cc_score:0.0 bp_score:0.0 mf_score:0.0125233 relationship: child_of NeXO:6558 ! CC: | BP: | MF: [Term] id: NeXO:6798 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.784211851 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7992 ! CC: | BP: proton-transporting ATP synthase complex biogenesis | MF: relationship: linked_to NeXO:7183 ! CC: | BP: | MF: [Term] id: NeXO:6799 name: CC: | BP: | MF:L-iditol 2-dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.50699128852448 density:0.5 bootstrap:0.8137053 cc_score:0.0 bp_score:0.0 mf_score:0.192445 relationship: child_of NeXO:7234 ! CC: | BP: ATP citrate synthase activity | MF:CoA-ligase activity [Term] id: NeXO:5854 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9244452476002 density:0.333333333333333 bootstrap:0.74987726 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6055 ! CC: | BP: | MF: [Term] id: NeXO:5855 name: CC: | BP: | MF:AMP binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with AMP, adenosine monophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.31409397177053 density:1 bootstrap:0.88732727 cc_score:0.0 bp_score:0.0 mf_score:0.175594 relationship: child_of NeXO:6842 ! CC: | BP: | MF: [Term] id: NeXO:5857 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.681575879 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6196 ! CC: | BP: | MF: [Term] id: NeXO:5850 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19703290413163 density:1 bootstrap:0.79982499 cc_score:0.0 bp_score:0.0734956 mf_score:0.0 relationship: child_of NeXO:7447 ! CC: | BP: | MF: relationship: linked_to NeXO:9147 ! CC: spindle midzone | BP: mitotic spindle stabilization | MF: [Term] id: NeXO:5851 name: CC: ornithine carbamoyltransferase complex | BP: ornithine carbamoyltransferase activity | MF:L-ornithine transmembrane transporter activity def: "CC_def: A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. | BP_def: Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. | MF_def:Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82269288 cc_score:0.437562 bp_score:0.471342 mf_score:0.440094 relationship: child_of NeXO:6184 ! CC: | BP: urea cycle | MF:argininosuccinate synthase activity [Term] id: NeXO:5852 name: CC: | BP: regulation of ornithine metabolic process | MF:arginase activity def: "CC_def: | BP_def: Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. | MF_def:Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80087189 cc_score:0.0 bp_score:0.449489 mf_score:0.446617 relationship: child_of NeXO:6466 ! CC: | BP: ornithine biosynthetic process | MF:ornithine carbamoyltransferase inhibitor activity [Term] id: NeXO:5853 name: CC: ISW1 complex | BP: | MF: def: "CC_def: A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35889902470639 density:1 bootstrap:0.922020439 cc_score:0.438576 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5854 ! CC: | BP: | MF: [Term] id: NeXO:8303 name: CC: | BP: inheritance of oxidatively modified proteins involved in replicative cell aging | MF:ADP binding def: "CC_def: | BP_def: A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells. | MF_def:Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.83908636202934 density:1 bootstrap:0.56043609 cc_score:0.0 bp_score:0.441149 mf_score:0.443453 relationship: child_of NeXO:8767 ! CC: | BP: trehalose metabolism in response to heat stress | MF:G-protein coupled receptor activity relationship: linked_to NeXO:7791 ! CC: | BP: | MF: relationship: linked_to NeXO:9748 ! CC: | BP: | MF: relationship: linked_to NeXO:9332 ! CC: | BP: | MF:ATPase inhibitor activity [Term] id: NeXO:5858 name: CC: | BP: maintenance of protein location in nucleus | MF: def: "CC_def: | BP_def: Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74236373 cc_score:0.0 bp_score:0.221556 mf_score:0.0 relationship: child_of NeXO:6619 ! CC: | BP: | MF: relationship: linked_to NeXO:9914 ! CC: | BP: regulation of tRNA export from nucleus | MF: [Term] id: NeXO:8302 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.4741786847077 density:0.972222222222222 bootstrap:0.874264796 cc_score:0.0 bp_score:0.0585018 mf_score:0.0747774 relationship: child_of NeXO:9395 ! CC: anaphase-promoting complex | BP: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: [Term] id: NeXO:8301 name: CC: | BP: chromosome decondensation | MF: def: "CC_def: | BP_def: The alteration of chromosome structure from the condensed form to a relaxed disperse form. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27180881366646 density:1 bootstrap:0.8551955 cc_score:0.0 bp_score:0.437864 mf_score:0.0 relationship: child_of NeXO:9727 ! CC: | BP: mitotic cell cycle G2/M transition decatenation checkpoint | MF: relationship: linked_to NeXO:7814 ! CC: | BP: | MF: relationship: linked_to NeXO:9356 ! CC: prefoldin complex | BP: tubulin complex assembly | MF: relationship: linked_to NeXO:9607 ! CC: | BP: activation of anaphase-promoting complex activity involved in meiotic cell cycle | MF:anaphase-promoting complex binding relationship: linked_to NeXO:9354 ! CC: | BP: | MF: [Term] id: NeXO:6580 name: CC: | BP: purine nucleotide salvage | MF: def: "CC_def: | BP_def: Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.95954097654192 density:0.190476190476190 bootstrap:0.565973025 cc_score:0.0 bp_score:0.104061 mf_score:0.0892294 relationship: child_of NeXO:7250 ! CC: | BP: | MF: [Term] id: NeXO:8758 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.84463146648446 density:0.666666666666667 bootstrap:0.73743706 cc_score:0.0 bp_score:0.0822686 mf_score:0.0 relationship: child_of NeXO:9285 ! CC: | BP: cell shape checkpoint | MF:protein phosphatase type 2A regulator activity relationship: linked_to NeXO:8377 ! CC: | BP: | MF: [Term] id: NeXO:8759 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.75885925621391 density:0.472222222222222 bootstrap:0.572688013 cc_score:0.0 bp_score:0.0525819 mf_score:0.0 relationship: child_of NeXO:9296 ! CC: | BP: | MF: [Term] id: NeXO:8208 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3497675675804 density:0.666666666666667 bootstrap:0.503179281 cc_score:0.0 bp_score:0.0307536 mf_score:0.0 relationship: child_of NeXO:9223 ! CC: | BP: | MF: relationship: linked_to NeXO:9216 ! CC: | BP: | MF: [Term] id: NeXO:6195 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.839362269 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7835 ! CC: | BP: | MF: [Term] id: NeXO:6584 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.00756882027777 density:0.666666666666667 bootstrap:0.82433566 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6998 ! CC: | BP: | MF: [Term] id: NeXO:6196 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62581116 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6619 ! CC: | BP: | MF: [Term] id: NeXO:7889 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07751005158627 density:0.194444444444444 bootstrap:0.359173649 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8329 ! CC: | BP: | MF: [Term] id: NeXO:8754 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05206809884349 density:1 bootstrap:0.6977589 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8865 ! CC: | BP: | MF: relationship: linked_to NeXO:8886 ! CC: | BP: maltose transport | MF:maltose:hydrogen symporter activity [Term] id: NeXO:8690 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.30143849487863 density:0.666666666666667 bootstrap:0.508466117 cc_score:0.0 bp_score:0.0436208 mf_score:0.0 relationship: child_of NeXO:9097 ! CC: | BP: | MF: [Term] id: NeXO:8755 name: CC: | BP: allantoin transport | MF:allantoin uptake transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [NeXO-GO:term] namespace: NeXO comment: robustness:1.84279462974162 density:1 bootstrap:0.562698455 cc_score:0.0 bp_score:0.443093 mf_score:0.442927 relationship: child_of NeXO:9326 ! CC: | BP: cellular amide catabolic process | MF:nucleobase:cation symporter activity relationship: linked_to NeXO:5485 ! CC: | BP: uracil transport | MF:uridine transmembrane transporter activity relationship: linked_to NeXO:9697 ! CC: | BP: | MF: relationship: linked_to NeXO:9122 ! CC: | BP: | MF: relationship: linked_to NeXO:8643 ! CC: | BP: | MF: [Term] id: NeXO:7881 name: CC: | BP: rRNA transcription | MF:RNA polymerase I regulatory region DNA binding def: "CC_def: | BP_def: The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. | MF_def:Interacting selectively with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [NeXO-GO:term] namespace: NeXO comment: robustness:4.06235031479951 density:0.141025641025641 bootstrap:0.44781473 cc_score:0.0 bp_score:0.180571 mf_score:0.308749 relationship: child_of NeXO:8834 ! CC: transcription factor complex | BP: transcription initiation, DNA-dependent | MF:regulation of transcription from RNA polymerase I promoter [Term] id: NeXO:6190 name: CC: | BP: | MF:phosphoglycerate dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.60316677162431 density:0.333333333333333 bootstrap:0.723334 cc_score:0.0 bp_score:0.0480107 mf_score:0.192399 relationship: child_of NeXO:6464 ! CC: | BP: | MF: [Term] id: NeXO:7883 name: CC: inner plaque of spindle pole body | BP: | MF: def: "CC_def: One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.78900300428487 density:0.666666666666667 bootstrap:0.70887703 cc_score:0.151657 bp_score:0.0377907 mf_score:0.0 relationship: child_of NeXO:9185 ! CC: | BP: | MF: relationship: linked_to NeXO:9356 ! CC: prefoldin complex | BP: tubulin complex assembly | MF: [Term] id: NeXO:7882 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.284051939 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8326 ! CC: | BP: | MF: [Term] id: NeXO:7885 name: CC: | BP: DNA transport | MF:DNA transport def: "CC_def: | BP_def: The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:3.71680486898194 density:0.5 bootstrap:0.5602964 cc_score:0.0 bp_score:0.349219 mf_score:0.347725 relationship: child_of NeXO:8325 ! CC: | BP: regulation of ion transport | MF:voltage-gated ion channel activity [Term] id: NeXO:7884 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.28515486192944 density:0.142857142857143 bootstrap:0.422696237 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9491 ! CC: | BP: | MF: [Term] id: NeXO:7887 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6570235208124 density:0.333333333333333 bootstrap:0.555950866 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9806 ! CC: | BP: | MF: relationship: linked_to NeXO:7571 ! CC: | BP: | MF: [Term] id: NeXO:7886 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.66599702139462 density:0.866666666666667 bootstrap:0.60203987 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8093 ! CC: Ino80 complex | BP: | MF:DNA end binding [Term] id: NeXO:6588 name: CC: | BP: succinyl-CoA metabolic process | MF:succinate-CoA ligase (ADP-forming) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. | MF_def:Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.01638031178548 density:1 bootstrap:0.89097976 cc_score:0.0 bp_score:0.58451 mf_score:0.591935 relationship: child_of NeXO:7234 ! CC: | BP: ATP citrate synthase activity | MF:CoA-ligase activity [Term] id: NeXO:9528 name: CC: rough endoplasmic reticulum membrane | BP: protein targeting to ER | MF: def: "CC_def: The lipid bilayer surrounding the rough endoplasmic reticulum. | BP_def: The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.96794520390501 density:0.098901098901099 bootstrap:0.142878764 cc_score:0.205099 bp_score:0.149386 mf_score:0.0 relationship: child_of NeXO:9794 ! CC: | BP: protein localization in endoplasmic reticulum | MF: [Term] id: NeXO:9529 name: CC: | BP: cAMP biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.15179924486948 density:0.0439560439560440 bootstrap:0.139531847 cc_score:0.0 bp_score:0.131422 mf_score:0.0 relationship: child_of NeXO:9803 ! CC: | BP: | MF: [Term] id: NeXO:9258 name: CC: SAGA complex | BP: protein deubiquitination | MF:histone acetylation def: "CC_def: A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. | BP_def: The removal of one or more ubiquitin groups from a protein. | MF_def:The modification of a histone by the addition of an acetyl group." [NeXO-GO:term] namespace: NeXO comment: robustness:16.4854074341622 density:1 bootstrap:0.81864074 cc_score:0.438491 bp_score:0.105876 mf_score:0.105839 relationship: child_of NeXO:9800 ! CC: SLIK (SAGA-like) complex | BP: histone acetylation | MF: [Term] id: NeXO:9259 name: CC: t-UTP complex | BP: positive regulation of transcription from RNA polymerase I promoter | MF: def: "CC_def: A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. | BP_def: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.29137497163342 density:0.583333333333333 bootstrap:0.509546054 cc_score:0.275442 bp_score:0.191158 mf_score:0.0 relationship: child_of NeXO:9887 ! CC: small-subunit processome | BP: rRNA 5'-end processing | MF:snoRNA binding [Term] id: NeXO:9524 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.88230475724759 density:1 bootstrap:0.41624 cc_score:0.0 bp_score:0.0449614 mf_score:0.0 relationship: child_of NeXO:9689 ! CC: preribosome, small subunit precursor | BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:8853 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:9119 ! CC: | BP: | MF: [Term] id: NeXO:9257 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15755199096961 density:0.5 bootstrap:0.404370374 cc_score:0.0 bp_score:0.0 mf_score:0.0606422 relationship: child_of NeXO:9329 ! CC: | BP: | MF: [Term] id: NeXO:9526 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10608414216455 density:0.466666666666667 bootstrap:0.288052571 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9643 ! CC: | BP: | MF: [Term] id: NeXO:9255 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.62584833040365 density:0.666666666666667 bootstrap:0.62836533 cc_score:0.0 bp_score:0.0135282 mf_score:0.0 relationship: child_of NeXO:9560 ! CC: | BP: | MF: [Term] id: NeXO:9520 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.1942094142679 density:0.5 bootstrap:0.67503228 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9833 ! CC: | BP: | MF: relationship: linked_to NeXO:9616 ! CC: | BP: regulation of transcription termination, DNA-dependent | MF: relationship: linked_to NeXO:9086 ! CC: transcription export complex | BP: | MF: [Term] id: NeXO:9253 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.24426432495252 density:0.143790849673203 bootstrap:0.248584339 cc_score:0.0 bp_score:0.0280673 mf_score:0.0 relationship: child_of NeXO:9513 ! CC: | BP: | MF: [Term] id: NeXO:9522 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.17011298418491 density:0.619047619047619 bootstrap:0.574626927 cc_score:0.0 bp_score:0.042695 mf_score:0.0 relationship: child_of NeXO:9845 ! CC: COPI-coated vesicle | BP: ER to Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9251 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81995104072521 density:0.2 bootstrap:0.400212343 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9644 ! CC: | BP: | MF: relationship: linked_to NeXO:8679 ! CC: | BP: | MF: [Term] id: NeXO:7867 name: CC: | BP: deoxyribonucleotide metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.35913020883392 density:0.2 bootstrap:0.374323598 cc_score:0.0 bp_score:0.134567 mf_score:0.0532925 relationship: child_of NeXO:8812 ! CC: | BP: | MF: [Term] id: NeXO:7865 name: CC: clathrin vesicle coat | BP: | MF: def: "CC_def: A clathrin coat found on a vesicle. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.5005374642276 density:0.263736263736264 bootstrap:0.59305352 cc_score:0.376069 bp_score:0.0138316 mf_score:0.0 relationship: child_of NeXO:8479 ! CC: clathrin coated vesicle membrane | BP: | MF: [Term] id: NeXO:7864 name: CC: transcription factor TFIIF complex | BP: regulation of protein serine/threonine phosphatase activity | MF:protein phosphatase activator activity def: "CC_def: A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. | BP_def: Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. | MF_def:Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.18585196754434 density:1 bootstrap:0.791704914 cc_score:0.586791 bp_score:0.440578 mf_score:0.440813 relationship: child_of NeXO:8986 ! CC: | BP: transcriptional start site selection at RNA polymerase II promoter | MF: relationship: linked_to NeXO:8370 ! CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding [Term] id: NeXO:7863 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.289678298 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8198 ! CC: | BP: | MF: relationship: linked_to NeXO:8475 ! CC: oligosaccharyltransferase complex | BP: protein N-linked glycosylation via asparagine | MF:dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Term] id: NeXO:8200 name: CC: | BP: regulation of exocytosis | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of exocytosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.52330541634669 density:0.666666666666667 bootstrap:0.580246567 cc_score:0.0 bp_score:0.132922 mf_score:0.0 relationship: child_of NeXO:9023 ! CC: | BP: | MF: relationship: linked_to NeXO:9471 ! CC: | BP: lipid tube assembly | MF: [Term] id: NeXO:7861 name: CC: | BP: protein-cofactor linkage | MF: def: "CC_def: | BP_def: The covalent attachment of a cofactor to a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.69977206437691 density:0.56060606060606 bootstrap:0.419450834 cc_score:0.0 bp_score:0.146275 mf_score:0.06887 relationship: child_of NeXO:8213 ! CC: | BP: acetyl-CoA biosynthetic process | MF:pyruvate dehydrogenase activity [Term] id: NeXO:7860 name: CC: | BP: protein localization to kinetochore | MF: def: "CC_def: | BP_def: Any process in which a protein is transported to, or maintained at, the kinetochore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.59524355293252 density:0.666666666666667 bootstrap:0.613803247 cc_score:0.0 bp_score:0.171683 mf_score:0.0 relationship: child_of NeXO:8201 ! CC: | BP: | MF: relationship: linked_to NeXO:8324 ! CC: | BP: | MF: [Term] id: NeXO:8093 name: CC: Ino80 complex | BP: | MF:DNA end binding def: "CC_def: A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity. | BP_def: | MF_def:Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [NeXO-GO:term] namespace: NeXO comment: robustness:9.0634104644978 density:0.857142857142857 bootstrap:0.80971946 cc_score:0.361359 bp_score:0.0 mf_score:0.136444 relationship: child_of NeXO:9806 ! CC: | BP: | MF: [Term] id: NeXO:8201 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.8465193336347 density:0.666666666666667 bootstrap:0.690226192 cc_score:0.0348534 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8590 ! CC: Ndc80 complex | BP: | MF: [Term] id: NeXO:7999 name: CC: | BP: pyrimidine ribonucleoside biosynthetic process | MF:orotate phosphoribosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. | MF_def:Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.427364237 cc_score:0.0 bp_score:0.293564 mf_score:0.294332 relationship: child_of NeXO:8798 ! CC: | BP: positive regulation of macroautophagy | MF: [Term] id: NeXO:7869 name: CC: | BP: short-chain fatty acid metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33814333242791 density:1 bootstrap:0.90586631 cc_score:0.0 bp_score:0.29245 mf_score:0.0 relationship: child_of NeXO:8858 ! CC: | BP: | MF: relationship: linked_to NeXO:7636 ! CC: | BP: negative regulation of transcription by competitive promoter binding | MF: [Term] id: NeXO:7868 name: CC: | BP: | MF:Rab geranylgeranyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24667637604451 density:1 bootstrap:0.836378546 cc_score:0.0 bp_score:0.0 mf_score:0.226561 relationship: child_of NeXO:8349 ! CC: | BP: | MF:protein geranylgeranyltransferase activity relationship: linked_to NeXO:9212 ! CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: [Term] id: NeXO:9435 name: CC: | BP: actin polymerization or depolymerization | MF: def: "CC_def: | BP_def: Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.22852848493312 density:0.266666666666667 bootstrap:0.350406245 cc_score:0.0 bp_score:0.390158 mf_score:0.0563469 relationship: child_of NeXO:9636 ! CC: | BP: regulation of protein polymerization | MF: [Term] id: NeXO:5827 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76403058 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7778 ! CC: | BP: mitochondrial tRNA wobble uridine modification | MF: [Term] id: NeXO:8232 name: CC: | BP: cytoplasmic sequestering of protein | MF: def: "CC_def: | BP_def: The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99517330219545 density:0.2 bootstrap:0.48098587 cc_score:0.0 bp_score:0.139994 mf_score:0.0 relationship: child_of NeXO:9806 ! CC: | BP: | MF: [Term] id: NeXO:6198 name: CC: | BP: heme catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.74201181381902 density:0.333333333333333 bootstrap:0.80255266 cc_score:0.0 bp_score:0.206311 mf_score:0.0 relationship: child_of NeXO:6699 ! CC: | BP: | MF: [Term] id: NeXO:5826 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.791823489 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6496 ! CC: | BP: | MF: [Term] id: NeXO:6199 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.47443185808917 density:0.166666666666667 bootstrap:0.511609572 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7147 ! CC: mitochondrial intermembrane space protein transporter complex | BP: inner mitochondrial membrane organization | MF: [Term] id: NeXO:6378 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29134913296349 density:0.666666666666667 bootstrap:0.47847084 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6712 ! CC: | BP: | MF:CoA hydrolase activity [Term] id: NeXO:9411 name: CC: CMG complex | BP: S phase of mitotic cell cycle | MF:DNA replication origin binding def: "CC_def: A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. | BP_def: S phase occurring as part of the mitotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. | MF_def:Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [NeXO-GO:term] namespace: NeXO comment: robustness:12.4218205686955 density:0.818181818181818 bootstrap:0.623357641 cc_score:0.399657 bp_score:0.292784 mf_score:0.185176 relationship: child_of NeXO:9576 ! CC: DNA replication preinitiation complex | BP: double-strand break repair via break-induced replication | MF: [Term] id: NeXO:9412 name: CC: | BP: cAMP-mediated signaling | MF: def: "CC_def: | BP_def: A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.61255361100699 density:0.4 bootstrap:0.321266515 cc_score:0.0 bp_score:0.125803 mf_score:0.0795908 relationship: child_of NeXO:9738 ! CC: | BP: | MF: [Term] id: NeXO:9413 name: CC: | BP: gluconeogenesis | MF:fructose-bisphosphate aldolase activity def: "CC_def: | BP_def: The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. | MF_def:Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:8.86517086374559 density:0.928571428571429 bootstrap:0.520503138 cc_score:0.0 bp_score:0.142294 mf_score:0.103345 relationship: child_of NeXO:9674 ! CC: | BP: glycolysis | MF: [Term] id: NeXO:9414 name: CC: | BP: ribonucleoprotein complex disassembly | MF: def: "CC_def: | BP_def: The disaggregation of a protein-RNA complex into its constituent components. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43734620612277 density:0.0476190476190476 bootstrap:0.685376987 cc_score:0.0 bp_score:0.139462 mf_score:0.0 relationship: child_of NeXO:9596 ! CC: U2-type catalytic step 1 spliceosome | BP: spliceosomal conformational changes to generate catalytic conformation | MF:RNA splicing, via transesterification reactions [Term] id: NeXO:9415 name: CC: | BP: ribosomal large subunit export from nucleus | MF: def: "CC_def: | BP_def: The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.52024088587763 density:0.428571428571429 bootstrap:0.489390323 cc_score:0.0 bp_score:0.118982 mf_score:0.0 relationship: child_of NeXO:9696 ! CC: | BP: NLS-bearing substrate import into nucleus | MF: [Term] id: NeXO:9416 name: CC: | BP: ribosomal protein import into nucleus | MF:protein export from nucleus def: "CC_def: | BP_def: The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. | MF_def:The directed movement of a protein from the nucleus into the cytoplasm." [NeXO-GO:term] namespace: NeXO comment: robustness:8.27228543715106 density:0.722222222222222 bootstrap:0.497349829 cc_score:0.0 bp_score:0.392496 mf_score:0.189813 relationship: child_of NeXO:9552 ! CC: nuclear membrane | BP: nuclear pore organization | MF: [Term] id: NeXO:9417 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.961263049091 density:0.878787878787879 bootstrap:0.51275061 cc_score:0.0 bp_score:0.0402494 mf_score:0.0 relationship: child_of NeXO:9628 ! CC: proteasome regulatory particle | BP: proteasome regulatory particle assembly | MF: [Term] id: NeXO:6370 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.46157635497731 density:0.1 bootstrap:0.57069168 cc_score:0.0 bp_score:0.0 mf_score:0.0723136 relationship: child_of NeXO:7841 ! CC: | BP: | MF: [Term] id: NeXO:6372 name: CC: | BP: | MF:magnesium ion transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:4.32843908774862 density:0.333333333333333 bootstrap:0.84439321 cc_score:0.0 bp_score:0.0 mf_score:0.234546 relationship: child_of NeXO:7106 ! CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: NeXO:6373 name: CC: | BP: protein-chromophore linkage | MF: def: "CC_def: | BP_def: The covalent or noncovalent attachment of a chromophore to a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.787722923 cc_score:0.0 bp_score:0.143176 mf_score:0.0 relationship: child_of NeXO:8003 ! CC: | BP: lysine biosynthetic process | MF: [Term] id: NeXO:6374 name: CC: | BP: regulation of thiamine biosynthetic process | MF:thiamine pyrophosphate binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine. | MF_def:Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [NeXO-GO:term] namespace: NeXO comment: robustness:4.73087751399103 density:0.5 bootstrap:0.90774051 cc_score:0.0 bp_score:0.356939 mf_score:0.243718 relationship: child_of NeXO:6982 ! CC: | BP: branched chain family amino acid catabolic process | MF: [Term] id: NeXO:6375 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.8373036083358 density:0.666666666666667 bootstrap:0.8929154 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6434 ! CC: | BP: | MF:monocarboxylic acid transmembrane transporter activity [Term] id: NeXO:6376 name: CC: | BP: | MF:L-leucine transaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-oxoglutaratic acid + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:2.53761330610428 density:0.127272727272727 bootstrap:0.277349173 cc_score:0.0 bp_score:0.0800484 mf_score:0.150962 relationship: child_of NeXO:6741 ! CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: NeXO:6377 name: CC: | BP: regulation of transcription during meiosis | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of transcription during meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.46621878356843 density:0.2 bootstrap:0.734910193 cc_score:0.0 bp_score:0.157731 mf_score:0.0 relationship: child_of NeXO:7710 ! CC: | BP: deoxyribonucleotide biosynthetic process | MF:oxidoreductase activity, acting on CH or CH2 groups [Term] id: NeXO:9340 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30690769897016 density:0.4 bootstrap:0.283005876 cc_score:0.0 bp_score:0.0718392 mf_score:0.0 relationship: child_of NeXO:9622 ! CC: | BP: positive regulation of spindle pole body separation | MF: [Term] id: NeXO:9617 name: CC: | BP: nuclear polyadenylation-dependent rRNA catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51062767751492 density:0.0842105263157895 bootstrap:0.142204968 cc_score:0.0 bp_score:0.125124 mf_score:0.0 relationship: child_of NeXO:9832 ! CC: | BP: | MF: [Term] id: NeXO:9342 name: CC: | BP: negative regulation of transcription factor import into nucleus | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.21505926505549 density:0.8 bootstrap:0.39944404 cc_score:0.0 bp_score:0.120837 mf_score:0.0 relationship: child_of NeXO:9703 ! CC: | BP: | MF: [Term] id: NeXO:9638 name: CC: NuA4 histone acetyltransferase complex | BP: | MF: def: "CC_def: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.6169807083165 density:0.972222222222222 bootstrap:0.649867656 cc_score:0.544937 bp_score:0.0821306 mf_score:0.0 relationship: child_of NeXO:9848 ! CC: H4/H2A histone acetyltransferase complex | BP: | MF: [Term] id: NeXO:9328 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.12641861910372 density:0.0329670329670330 bootstrap:0.193569425 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9637 ! CC: | BP: | MF: [Term] id: NeXO:9329 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.52395224411909 density:0.785714285714286 bootstrap:0.354823551 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9697 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:9630 name: CC: Swr1 complex | BP: histone exchange | MF: def: "CC_def: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. | BP_def: The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.4212545664041 density:0.833333333333333 bootstrap:0.65188915 cc_score:0.355351 bp_score:0.330284 mf_score:0.0 relationship: child_of NeXO:9751 ! CC: | BP: | MF: [Term] id: NeXO:9323 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.13608134908184 density:1 bootstrap:0.213865488 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9557 ! CC: | BP: | MF: relationship: linked_to NeXO:8983 ! CC: | BP: | MF: relationship: linked_to NeXO:8150 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:9632 name: CC: | BP: cellular hypotonic response | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.55902814866306 density:0.318681318681319 bootstrap:0.25617377 cc_score:0.0 bp_score:0.117944 mf_score:0.0128389 relationship: child_of NeXO:9818 ! CC: | BP: cellular response to osmotic stress | MF: [Term] id: NeXO:9321 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.99501906699317 density:0.523809523809524 bootstrap:0.465180873 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9507 ! CC: | BP: | MF: relationship: linked_to NeXO:9635 ! CC: | BP: | MF: [Term] id: NeXO:9326 name: CC: | BP: cellular amide catabolic process | MF:nucleobase:cation symporter activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.60762815327833 density:0.6 bootstrap:0.284101293 cc_score:0.0 bp_score:0.134911 mf_score:0.124829 relationship: child_of NeXO:9752 ! CC: | BP: | MF: relationship: linked_to NeXO:9353 ! CC: | BP: | MF: relationship: linked_to NeXO:9445 ! CC: | BP: | MF: [Term] id: NeXO:9635 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.2165366121631 density:0.755555555555556 bootstrap:0.466231289 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9787 ! CC: | BP: | MF: relationship: linked_to NeXO:9663 ! CC: | BP: | MF: [Term] id: NeXO:9324 name: CC: | BP: chaperone cofactor-dependent protein refolding | MF: def: "CC_def: | BP_def: The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04608412877608 density:0.4 bootstrap:0.22262913 cc_score:0.0 bp_score:0.162932 mf_score:0.0 relationship: child_of NeXO:9660 ! CC: | BP: | MF: [Term] id: NeXO:9325 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.7238416836062 density:1 bootstrap:0.81333812 cc_score:0.0 bp_score:0.0886113 mf_score:0.0 relationship: child_of NeXO:9677 ! CC: | BP: | MF: [Term] id: NeXO:8941 name: CC: Golgi lumen | BP: | MF: def: "CC_def: The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64327860100222 density:1 bootstrap:0.447449726 cc_score:0.219479 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9418 ! CC: | BP: inter-Golgi cisterna vesicle-mediated transport | MF: relationship: linked_to NeXO:9651 ! CC: | BP: detoxification of arsenic-containing substance | MF: relationship: linked_to NeXO:8780 ! CC: Golgi transport complex | BP: intra-Golgi vesicle-mediated transport | MF: relationship: linked_to NeXO:9168 ! CC: | BP: | MF: [Term] id: NeXO:8940 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.28029936411172 density:1 bootstrap:0.59432656 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9183 ! CC: | BP: | MF: relationship: linked_to NeXO:9270 ! CC: | BP: | MF: [Term] id: NeXO:8943 name: CC: integral to Golgi membrane | BP: | MF: def: "CC_def: Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.59084895917765 density:0.333333333333333 bootstrap:0.42122244 cc_score:0.10923 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9458 ! CC: | BP: | MF: [Term] id: NeXO:8944 name: CC: Nup82 complex | BP: ncRNA export from nucleus | MF: def: "CC_def: A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p. | BP_def: The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.00198383953553 density:0.666666666666667 bootstrap:0.365253238 cc_score:0.282173 bp_score:0.231142 mf_score:0.0 relationship: child_of NeXO:9091 ! CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: relationship: linked_to NeXO:8376 ! CC: Nup107-160 complex | BP: snRNA export from nucleus | MF: relationship: linked_to NeXO:8283 ! CC: | BP: | MF:protein-arginine N-methyltransferase activity [Term] id: NeXO:8947 name: CC: PeBoW complex | BP: | MF: def: "CC_def: A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.79578990996737 density:1 bootstrap:0.397895382 cc_score:0.350853 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9106 ! CC: | BP: | MF: relationship: linked_to NeXO:9293 ! CC: | BP: | MF: relationship: linked_to NeXO:9083 ! CC: | BP: | MF: [Term] id: NeXO:8946 name: CC: | BP: snRNA pseudouridine synthesis | MF: def: "CC_def: | BP_def: The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.59289525972128 density:0.571428571428571 bootstrap:0.72623936 cc_score:0.0641745 bp_score:0.282766 mf_score:0.0 relationship: child_of NeXO:9644 ! CC: | BP: | MF: [Term] id: NeXO:8949 name: CC: | BP: | MF:eukaryotic translation initiation factor 2alpha kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.76524716671329 density:1 bootstrap:0.516336579 cc_score:0.0 bp_score:0.0 mf_score:0.437829 relationship: child_of NeXO:9443 ! CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity relationship: linked_to NeXO:9403 ! CC: eukaryotic translation initiation factor 2B complex | BP: regulation of translational initiation | MF: relationship: linked_to NeXO:6051 ! CC: | BP: | MF: relationship: linked_to NeXO:8839 ! CC: | BP: | MF: relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: [Term] id: NeXO:8948 name: CC: | BP: cytokinetic cell separation involved in cell cycle cytokinesis | MF: def: "CC_def: | BP_def: Any cytokinetic cell separation that is involved in cell cycle cytokinesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28455154050081 density:0.666666666666667 bootstrap:0.475636156 cc_score:0.0 bp_score:0.428704 mf_score:0.0 relationship: child_of NeXO:9687 ! CC: | BP: | MF: relationship: linked_to NeXO:6562 ! CC: | BP: | MF:chitin binding [Term] id: NeXO:7267 name: CC: | BP: DNA replication-dependent nucleosome assembly | MF: def: "CC_def: | BP_def: The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.00766668826026 density:1 bootstrap:0.667890203 cc_score:0.0 bp_score:0.353936 mf_score:0.0 relationship: child_of NeXO:7372 ! CC: | BP: heterochromatin formation involved in chromatin silencing | MF: [Term] id: NeXO:9347 name: CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [NeXO-GO:term] namespace: NeXO comment: robustness:7.80136402857015 density:1 bootstrap:0.67228711 cc_score:0.0 bp_score:0.0 mf_score:0.150931 relationship: child_of NeXO:9514 ! CC: | BP: | MF:dolichyl-phosphate beta-glucosyltransferase activity relationship: linked_to NeXO:9349 ! CC: | BP: | MF: [Term] id: NeXO:7261 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.11737340867216 density:0.666666666666667 bootstrap:0.79085362 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8106 ! CC: | BP: | MF:4-alpha-glucanotransferase activity relationship: linked_to NeXO:9095 ! CC: | BP: regulation of transcription from RNA polymerase II promoter by pheromones | MF: [Term] id: NeXO:7260 name: CC: | BP: | MF:cardiolipin synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol + glycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.371149323 cc_score:0.0 bp_score:0.0 mf_score:0.440292 relationship: child_of NeXO:8149 ! CC: | BP: | MF: [Term] id: NeXO:7263 name: CC: | BP: vacuolar proton-transporting V-type ATPase complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.76912858428416 density:0.7 bootstrap:0.607095664 cc_score:0.0 bp_score:0.399466 mf_score:0.0 relationship: child_of NeXO:7769 ! CC: | BP: proton-transporting two-sector ATPase complex assembly | MF: [Term] id: NeXO:7262 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.04616515455095 density:0.666666666666667 bootstrap:0.7637352 cc_score:0.0 bp_score:0.0829758 mf_score:0.0 relationship: child_of NeXO:8808 ! CC: | BP: | MF: [Term] id: NeXO:6204 name: CC: | BP: | MF:palmitoyl-CoA hydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.670016897 cc_score:0.0 bp_score:0.0 mf_score:0.317959 relationship: child_of NeXO:7231 ! CC: | BP: dUTP catabolic process | MF:dUTP diphosphatase activity [Term] id: NeXO:6205 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84209363 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7563 ! CC: | BP: | MF: [Term] id: NeXO:6206 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07053611314695 density:0.666666666666667 bootstrap:0.859214028 cc_score:0.0 bp_score:0.025338 mf_score:0.0 relationship: child_of NeXO:6609 ! CC: | BP: | MF: [Term] id: NeXO:6207 name: CC: | BP: | MF:S-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7144611 cc_score:0.0 bp_score:0.0 mf_score:0.120046 relationship: child_of NeXO:6799 ! CC: | BP: | MF:L-iditol 2-dehydrogenase activity [Term] id: NeXO:6200 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.51227609687712 density:0.5 bootstrap:0.81615955 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7956 ! CC: | BP: | MF: [Term] id: NeXO:6201 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99336123736669 density:0.333333333333333 bootstrap:0.804546375 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6805 ! CC: | BP: | MF: [Term] id: NeXO:6202 name: CC: | BP: negative regulation of histone deacetylation | MF:negative regulation of histone deacetylation def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones. | MF_def:Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76526781 cc_score:0.0 bp_score:0.270132 mf_score:0.268093 relationship: child_of NeXO:7309 ! CC: | BP: positive regulation of protein dephosphorylation | MF: [Term] id: NeXO:6203 name: CC: | BP: alanine biosynthetic process | MF:L-valine transaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. | MF_def:Catalysis of the reaction: 2-oxoglutaratic acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:2.57057675256773 density:0.666666666666667 bootstrap:0.602190765 cc_score:0.0 bp_score:0.269379 mf_score:0.573788 relationship: child_of NeXO:6376 ! CC: | BP: | MF:L-leucine transaminase activity [Term] id: NeXO:6952 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.62075663927467 density:0.2 bootstrap:0.572059447 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7664 ! CC: | BP: | MF: [Term] id: NeXO:6208 name: CC: | BP: polyol biosynthetic process | MF:alkaline phosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. | MF_def:Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85137599 cc_score:0.0 bp_score:0.122644 mf_score:0.201383 relationship: child_of NeXO:7564 ! CC: | BP: glycerol metabolic process | MF: [Term] id: NeXO:6209 name: CC: mitochondrial proton-transporting ATP synthase, catalytic core | BP: protein complex oligomerization | MF: def: "CC_def: The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. | BP_def: The association of two or more multisubunit protein complexes to form dimers or other multimers of a protein complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.08810003987993 density:1 bootstrap:0.92308397 cc_score:0.589984 bp_score:0.292819 mf_score:0.0 relationship: child_of NeXO:8701 ! CC: mitochondrial proton-transporting ATP synthase complex | BP: ATP synthesis coupled proton transport | MF:hydrogen ion transporting ATP synthase activity, rotational mechanism relationship: linked_to NeXO:5296 ! CC: | BP: protein oligomerization | MF: relationship: linked_to NeXO:8104 ! CC: | BP: mitochondrial proton-transporting ATP synthase complex assembly | MF: relationship: linked_to NeXO:5492 ! CC: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) | BP: | MF: [Term] id: NeXO:6808 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.465717526 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6832 ! CC: | BP: | MF: [Term] id: NeXO:6809 name: CC: integral to nuclear inner membrane | BP: | MF: def: "CC_def: Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.00358214717844 density:1 bootstrap:0.66517536 cc_score:0.221306 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8408 ! CC: | BP: | MF: relationship: linked_to NeXO:8741 ! CC: | BP: protein localization to nucleolar rDNA repeats | MF:rDNA spacer replication fork barrier binding [Term] id: NeXO:6806 name: CC: | BP: base-excision repair, AP site formation | MF:oxidized base lesion DNA N-glycosylase activity def: "CC_def: | BP_def: The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. | MF_def:Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [NeXO-GO:term] namespace: NeXO comment: robustness:4.89334497251308 density:0.833333333333333 bootstrap:0.843554377 cc_score:0.0 bp_score:0.493002 mf_score:0.613666 relationship: child_of NeXO:7779 ! CC: | BP: base-excision repair | MF:DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: NeXO:6807 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.666139115 cc_score:0.0 bp_score:0.0 mf_score:0.0235268 relationship: child_of NeXO:8062 ! CC: | BP: | MF: [Term] id: NeXO:6804 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87059736751206 density:0.166666666666667 bootstrap:0.823473991 cc_score:0.0 bp_score:0.0100311 mf_score:0.0 relationship: child_of NeXO:7258 ! CC: EKC/KEOPS complex | BP: threonylcarbamoyladenosine metabolic process | MF:chromatin DNA binding [Term] id: NeXO:6805 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.77105217587204 density:0.166666666666667 bootstrap:0.73816247 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7529 ! CC: | BP: | MF: [Term] id: NeXO:6802 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58401789 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7562 ! CC: | BP: | MF: [Term] id: NeXO:6803 name: CC: | BP: organelle membrane fusion | MF: def: "CC_def: | BP_def: The joining of two lipid bilayers to form a single organelle membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08888933693537 density:0.2 bootstrap:0.52723221 cc_score:0.0 bp_score:0.10298 mf_score:0.0 relationship: child_of NeXO:7313 ! CC: | BP: | MF: [Term] id: NeXO:6800 name: CC: | BP: | MF:squalene synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.78915031059232 density:0.333333333333333 bootstrap:0.648145815 cc_score:0.0 bp_score:0.0 mf_score:0.319317 relationship: child_of NeXO:7098 ! CC: | BP: | MF:delta14-sterol reductase activity [Term] id: NeXO:10009 name: CC: | BP: cellular localization | MF: def: "CC_def: | BP_def: A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.19143296992518 density:0.0140788395141459 bootstrap:0.115214602 cc_score:0.091794 bp_score:0.134116 mf_score:0.0734283 relationship: child_of NeXO:10015 ! CC: nuclear part | BP: cellular component organization at cellular level | MF:regulation of transcription, DNA-dependent [Term] id: NeXO:9744 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.32813457371411 density:0.0700757575757576 bootstrap:0.201152597 cc_score:0.0600293 bp_score:0.051729 mf_score:0.0 relationship: child_of NeXO:9981 ! CC: endosome | BP: vesicle-mediated transport | MF:protein transport [Term] id: NeXO:9745 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.39829619910575 density:0.0196491228070175 bootstrap:0.16043073 cc_score:0.0 bp_score:0.0234376 mf_score:0.0236334 relationship: child_of NeXO:9895 ! CC: | BP: | MF: [Term] id: NeXO:9746 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.61610793024642 density:0.0854700854700855 bootstrap:0.083546678 cc_score:0.0 bp_score:0.0580647 mf_score:0.0312899 relationship: child_of NeXO:9894 ! CC: | BP: | MF: [Term] id: NeXO:9747 name: CC: | BP: energy reserve metabolic process | MF:phosphatase regulator activity def: "CC_def: | BP_def: The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. | MF_def:Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:8.5942279771493 density:0.096326530612245 bootstrap:0.22382649 cc_score:0.0 bp_score:0.107857 mf_score:0.149819 relationship: child_of NeXO:9900 ! CC: | BP: | MF: [Term] id: NeXO:9740 name: CC: | BP: translational initiation | MF:translation initiation factor activity def: "CC_def: | BP_def: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. | MF_def:Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [NeXO-GO:term] namespace: NeXO comment: robustness:14.3468970985373 density:0.336956521739130 bootstrap:0.529883889 cc_score:0.0958821 bp_score:0.219285 mf_score:0.34142 relationship: child_of NeXO:9888 ! CC: | BP: | MF:translational initiation [Term] id: NeXO:9741 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.80493166974875 density:0.8 bootstrap:0.218334942 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9808 ! CC: | BP: | MF: relationship: linked_to NeXO:9261 ! CC: heterochromatin | BP: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9372 ! CC: | BP: | MF: [Term] id: NeXO:9742 name: CC: core mediator complex | BP: | MF:RNA polymerase II transcription cofactor activity def: "CC_def: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. | BP_def: | MF_def:Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [NeXO-GO:term] namespace: NeXO comment: robustness:21.7475000714092 density:0.956709956709957 bootstrap:0.645000063 cc_score:0.702775 bp_score:0.0817174 mf_score:0.329087 relationship: child_of NeXO:9843 ! CC: mediator complex | BP: negative regulation of transcription from RNA polymerase II promoter | MF:RNA polymerase II transcription factor binding transcription factor activity [Term] id: NeXO:9743 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16285678455591 density:0.0466666666666667 bootstrap:0.151990724 cc_score:0.0864771 bp_score:0.0472593 mf_score:0.0 relationship: child_of NeXO:9981 ! CC: endosome | BP: vesicle-mediated transport | MF:protein transport [Term] id: NeXO:9619 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.04743572217736 density:0.5 bootstrap:0.426502578 cc_score:0.0 bp_score:0.0328862 mf_score:0.0 relationship: child_of NeXO:9918 ! CC: | BP: | MF: [Term] id: NeXO:9748 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.88580013911523 density:0.5 bootstrap:0.550972941 cc_score:0.0761423 bp_score:0.0162184 mf_score:0.0 relationship: child_of NeXO:9971 ! CC: | BP: protein refolding | MF: relationship: linked_to NeXO:9317 ! CC: | BP: | MF: relationship: linked_to NeXO:9753 ! CC: | BP: | MF: relationship: linked_to NeXO:9324 ! CC: | BP: chaperone cofactor-dependent protein refolding | MF: relationship: linked_to NeXO:7569 ! CC: | BP: | MF: [Term] id: NeXO:9749 name: CC: | BP: positive regulation of receptor-mediated endocytosis | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.290366287 cc_score:0.0547939 bp_score:0.440443 mf_score:0.0 relationship: child_of NeXO:9914 ! CC: | BP: regulation of tRNA export from nucleus | MF: relationship: linked_to NeXO:5412 ! CC: | BP: | MF:nucleotide phosphatase activity relationship: linked_to NeXO:8436 ! CC: | BP: | MF: relationship: linked_to NeXO:7739 ! CC: | BP: | MF: relationship: linked_to NeXO:5103 ! CC: | BP: | MF: relationship: linked_to NeXO:7489 ! CC: vacuolar lumen | BP: positive regulation of ubiquitin-dependent endocytosis | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity [Term] id: NeXO:5182 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.890954188 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5381 ! CC: | BP: | MF: [Term] id: NeXO:5183 name: CC: centromere-specific nucleosome | BP: | MF: def: "CC_def: A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86280858 cc_score:0.297584 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5785 ! CC: condensed chromosome inner kinetochore | BP: | MF: [Term] id: NeXO:5181 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53887913 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5199 ! CC: | BP: nicotinamide metabolic process | MF:nicotinamide N-methyltransferase activity [Term] id: NeXO:5186 name: CC: | BP: | MF:ketoreductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reduction of a ketone group to form the corresponding alcohol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79362331 cc_score:0.0 bp_score:0.0 mf_score:0.251143 relationship: child_of NeXO:5472 ! CC: | BP: | MF: [Term] id: NeXO:5187 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82324182 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5396 ! CC: | BP: | MF: [Term] id: NeXO:5184 name: CC: | BP: | MF:phosphomethylpyrimidine kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8370765 cc_score:0.0 bp_score:0.0 mf_score:0.220403 relationship: child_of NeXO:6039 ! CC: | BP: | MF: [Term] id: NeXO:5185 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8036111 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5470 ! CC: | BP: positive regulation of transcription involved in G2/M-phase of mitotic cell cycle | MF: [Term] id: NeXO:5188 name: CC: | BP: pyridoxal 5'-phosphate salvage | MF:pyridoxal kinase activity def: "CC_def: | BP_def: Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. | MF_def:Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.848513858 cc_score:0.0 bp_score:0.295143 mf_score:0.291824 relationship: child_of NeXO:5394 ! CC: | BP: | MF: [Term] id: NeXO:5189 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.16467862211751 density:0.0128205128205128 bootstrap:0.766758729 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6766 ! CC: | BP: | MF: [Term] id: NeXO:8839 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.888447161787967 density:0.0666666666666667 bootstrap:0.236068594 cc_score:0.0 bp_score:0.0155186 mf_score:0.0 relationship: child_of NeXO:9487 ! CC: | BP: | MF: [Term] id: NeXO:8838 name: CC: | BP: cis assembly of pre-catalytic spliceosome | MF: def: "CC_def: | BP_def: Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.68017247617868 density:0.666666666666667 bootstrap:0.616259503 cc_score:0.0 bp_score:0.1235 mf_score:0.0655563 relationship: child_of NeXO:9188 ! CC: | BP: generation of catalytic spliceosome for second transesterification step | MF:second spliceosomal transesterification activity [Term] id: NeXO:8835 name: CC: | BP: regulation of G-protein coupled receptor protein signaling pathway | MF:peptide-methionine (R)-S-oxide reductase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. | MF_def:Catalysis of the reaction: L-methionine residue + H(2)O + thioredoxin disulfide = L-methionine (R)-S-oxide residue + thioredoxin." [NeXO-GO:term] namespace: NeXO comment: robustness:2.85525224018809 density:1 bootstrap:0.450284649 cc_score:0.0 bp_score:0.12585 mf_score:0.296893 relationship: child_of NeXO:9197 ! CC: | BP: | MF: relationship: linked_to NeXO:8545 ! CC: | BP: | MF:sterol-transporting ATPase activity relationship: linked_to NeXO:6968 ! CC: | BP: | MF:polynucleotide 3'-phosphatase activity relationship: linked_to NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity [Term] id: NeXO:8834 name: CC: transcription factor complex | BP: transcription initiation, DNA-dependent | MF:regulation of transcription from RNA polymerase I promoter def: "CC_def: A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. | BP_def: Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. | MF_def:Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:5.30667963892023 density:0.142857142857143 bootstrap:0.287641083 cc_score:0.151131 bp_score:0.100773 mf_score:0.186714 relationship: child_of NeXO:9521 ! CC: | BP: | MF:transcription from RNA polymerase I promoter [Term] id: NeXO:8830 name: CC: | BP: regulation of initiation of mating projection growth | MF:protein serine/threonine/tyrosine kinase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi. | MF_def:Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.74542814030297 density:0.333333333333333 bootstrap:0.61685489 cc_score:0.0 bp_score:0.186668 mf_score:0.158265 relationship: child_of NeXO:9376 ! CC: | BP: regulation of fungal-type cell wall organization | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding [Term] id: NeXO:8833 name: CC: | BP: transcription initiation from RNA polymerase III promoter | MF:core RNA polymerase III binding transcription factor activity def: "CC_def: | BP_def: Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. | MF_def:Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [NeXO-GO:term] namespace: NeXO comment: robustness:6.11199462938388 density:0.678571428571429 bootstrap:0.377553987 cc_score:0.0 bp_score:0.418499 mf_score:0.144314 relationship: child_of NeXO:8834 ! CC: transcription factor complex | BP: transcription initiation, DNA-dependent | MF:regulation of transcription from RNA polymerase I promoter [Term] id: NeXO:7399 name: CC: | BP: peptidyl-serine phosphorylation | MF:pyruvate dehydrogenase (acetyl-transferring) kinase activity def: "CC_def: | BP_def: The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. | MF_def:Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.45068678223378 density:0.333333333333333 bootstrap:0.426114559 cc_score:0.0 bp_score:0.160562 mf_score:0.200783 relationship: child_of NeXO:7861 ! CC: | BP: protein-cofactor linkage | MF: [Term] id: NeXO:6471 name: CC: | BP: cell wall mannoprotein biosynthetic process | MF:alpha-1,2-mannosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. | MF_def:Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:3.9876200628956 density:1 bootstrap:0.8782653 cc_score:0.0 bp_score:0.222569 mf_score:0.290657 relationship: child_of NeXO:7617 ! CC: | BP: N-glycan processing | MF: [Term] id: NeXO:5625 name: CC: | BP: negative regulation of phosphorylation | MF:cAMP-dependent protein kinase inhibitor activity def: "CC_def: | BP_def: Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. | MF_def:Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.848039741 cc_score:0.0 bp_score:0.296413 mf_score:0.222982 relationship: child_of NeXO:6081 ! CC: | BP: positive regulation of Ras protein signal transduction | MF: [Term] id: NeXO:5480 name: CC: | BP: cellular biogenic amine catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86204731482237 density:0.166666666666667 bootstrap:0.81596339 cc_score:0.0 bp_score:0.127944 mf_score:0.0133643 relationship: child_of NeXO:6740 ! CC: | BP: acetate metabolic process | MF:aldehyde dehydrogenase (NAD) activity [Term] id: NeXO:8582 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09109115820496 density:1 bootstrap:0.724549028 cc_score:0.0 bp_score:0.0602618 mf_score:0.0 relationship: child_of NeXO:9420 ! CC: kinetochore microtubule | BP: regulation of cell division | MF: relationship: linked_to NeXO:6920 ! CC: | BP: | MF: relationship: linked_to NeXO:8590 ! CC: Ndc80 complex | BP: | MF: [Term] id: NeXO:9227 name: CC: CCR4-NOT core complex | BP: nuclear-transcribed mRNA poly(A) tail shortening | MF:poly(A)-specific ribonuclease activity def: "CC_def: The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p. | BP_def: Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. | MF_def:Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [NeXO-GO:term] namespace: NeXO comment: robustness:13.0276506594422 density:0.972222222222222 bootstrap:0.81727948 cc_score:0.777183 bp_score:0.365825 mf_score:0.152629 relationship: child_of NeXO:9468 ! CC: CCR4-NOT complex | BP: | MF: [Term] id: NeXO:7679 name: CC: | BP: rRNA (guanine-N7)-methylation | MF:rRNA (guanine-N7)-methylation def: "CC_def: | BP_def: The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule. | MF_def:The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.638830392 cc_score:0.0 bp_score:0.438543 mf_score:0.4375 relationship: child_of NeXO:8081 ! CC: | BP: | MF:rRNA (guanine) methyltransferase activity [Term] id: NeXO:7676 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10848498211009 density:0.214285714285714 bootstrap:0.4126455 cc_score:0.0 bp_score:0.0323383 mf_score:0.0 relationship: child_of NeXO:8619 ! CC: | BP: | MF: [Term] id: NeXO:7674 name: CC: | BP: | MF:borate efflux transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [NeXO-GO:term] namespace: NeXO comment: robustness:4.29821605216429 density:0.7 bootstrap:0.493123331 cc_score:0.0 bp_score:0.0 mf_score:0.142609 relationship: child_of NeXO:8245 ! CC: | BP: | MF:borate transmembrane transporter activity [Term] id: NeXO:7675 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25780457994071 density:0.107142857142857 bootstrap:0.506949147 cc_score:0.0 bp_score:0.0505739 mf_score:0.0 relationship: child_of NeXO:9049 ! CC: | BP: | MF: [Term] id: NeXO:8234 name: CC: | BP: reactive oxygen species metabolic process | MF:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. | MF_def:Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:5.02409708123679 density:1 bootstrap:0.69707677 cc_score:0.0 bp_score:0.114965 mf_score:0.354527 relationship: child_of NeXO:8988 ! CC: phosphopyruvate hydratase complex | BP: | MF:phosphopyruvate hydratase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:7673 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.96199938617889 density:0.104761904761905 bootstrap:0.262331026 cc_score:0.0 bp_score:0.0450362 mf_score:0.0 relationship: child_of NeXO:8504 ! CC: | BP: re-entry into mitotic cell cycle | MF: [Term] id: NeXO:7670 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.339126597 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8602 ! CC: | BP: thiamine metabolic process | MF: [Term] id: NeXO:7671 name: CC: | BP: | MF:SSU rRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64778726 cc_score:0.0 bp_score:0.0 mf_score:0.175447 relationship: child_of NeXO:8192 ! CC: | BP: | MF: [Term] id: NeXO:5459 name: CC: sulfite reductase complex (NADPH) | BP: purine ribonucleoside salvage | MF:sulfite reductase (NADPH) activity def: "CC_def: A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. | BP_def: Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. | MF_def:Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52685652 cc_score:0.230119 bp_score:0.116361 mf_score:0.233085 relationship: child_of NeXO:5710 ! CC: | BP: | MF:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [Term] id: NeXO:9596 name: CC: U2-type catalytic step 1 spliceosome | BP: spliceosomal conformational changes to generate catalytic conformation | MF:RNA splicing, via transesterification reactions def: "CC_def: A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. | BP_def: Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. | MF_def:Splicing of RNA via a series of two transesterification reactions." [NeXO-GO:term] namespace: NeXO comment: robustness:15.7826962589326 density:0.681318681318681 bootstrap:0.778996168 cc_score:0.177392 bp_score:0.147501 mf_score:0.247213 relationship: child_of NeXO:9834 ! CC: U2-type precatalytic spliceosome | BP: | MF: [Term] id: NeXO:7078 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10071258110236 density:0.666666666666667 bootstrap:0.8761853 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7079 ! CC: | BP: | MF: [Term] id: NeXO:7079 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.5365836165156 density:0.3 bootstrap:0.48268206 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8128 ! CC: | BP: | MF: [Term] id: NeXO:5450 name: CC: | BP: | MF:aryl-alcohol dehydrogenase activity def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.11741485768039 density:0.666666666666667 bootstrap:0.88565003 cc_score:0.0 bp_score:0.0969578 mf_score:0.303106 relationship: child_of NeXO:5451 ! CC: | BP: | MF: [Term] id: NeXO:5451 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.44763404995087 density:0.333333333333333 bootstrap:0.89153871 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6065 ! CC: | BP: | MF: [Term] id: NeXO:5452 name: CC: | BP: activation of mitotic anaphase-promoting complex activity | MF:mitotic anaphase-promoting complex activity def: "CC_def: | BP_def: Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex that regulates the mitotic metaphase/anaphase transition. | MF_def:A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [NeXO-GO:term] namespace: NeXO comment: robustness:3.1290059310027 density:1 bootstrap:0.54076796 cc_score:0.0 bp_score:0.177717 mf_score:0.296654 relationship: child_of NeXO:5738 ! CC: | BP: | MF:positive regulation of mitotic metaphase/anaphase transition [Term] id: NeXO:7077 name: CC: | BP: | MF:double-stranded DNA specific 5'-3' exodeoxyribonuclease activity def: "CC_def: | BP_def: | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:4.39587294775868 density:0.4 bootstrap:0.69733308 cc_score:0.0 bp_score:0.0 mf_score:0.133484 relationship: child_of NeXO:7964 ! CC: | BP: | MF: [Term] id: NeXO:5454 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97288454810352 density:0.333333333333333 bootstrap:0.78810196 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6200 ! CC: | BP: | MF: [Term] id: NeXO:5455 name: CC: mitochondrial DNA-directed RNA polymerase complex | BP: transcription from mitochondrial promoter | MF:transcription from mitochondrial promoter def: "CC_def: A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form. | BP_def: The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. | MF_def:The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [NeXO-GO:term] namespace: NeXO comment: robustness:3.09889538346013 density:0.666666666666667 bootstrap:0.87515861 cc_score:0.569364 bp_score:0.428337 mf_score:0.229402 relationship: child_of NeXO:5456 ! CC: | BP: Group II intron splicing | MF: [Term] id: NeXO:5456 name: CC: | BP: Group II intron splicing | MF: def: "CC_def: | BP_def: The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.70669864313905 density:0.333333333333333 bootstrap:0.78201432 cc_score:0.0 bp_score:0.199861 mf_score:0.0888512 relationship: child_of NeXO:5824 ! CC: | BP: RNA folding | MF: [Term] id: NeXO:9222 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07832766768813 density:0.4 bootstrap:0.503923611 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9754 ! CC: | BP: | MF: relationship: linked_to NeXO:9496 ! CC: integral to endosome membrane | BP: Golgi to plasma membrane protein transport | MF: [Term] id: NeXO:9847 name: CC: | BP: chromatin remodeling | MF: def: "CC_def: | BP_def: Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.8855819882832 density:0.430107526881720 bootstrap:0.486409245 cc_score:0.0 bp_score:0.271456 mf_score:0.0303163 relationship: child_of NeXO:9982 ! CC: chromatin remodeling complex | BP: nucleosome organization | MF: [Term] id: NeXO:9592 name: CC: peripheral to membrane of membrane fraction | BP: vesicle fusion with Golgi apparatus | MF:syntaxin binding def: "CC_def: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH. | BP_def: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. | MF_def:Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [NeXO-GO:term] namespace: NeXO comment: robustness:8.02486577651459 density:1 bootstrap:0.71135969 cc_score:0.120043 bp_score:0.352641 mf_score:0.148831 relationship: child_of NeXO:9694 ! CC: | BP: | MF: relationship: linked_to NeXO:9695 ! CC: | BP: protein insertion into membrane | MF: [Term] id: NeXO:6477 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.21189769254065 density:0.666666666666667 bootstrap:0.94014826 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6478 ! CC: | BP: positive regulation of mRNA processing | MF: [Term] id: NeXO:8163 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.0278116104701 density:0.450292397660819 bootstrap:0.733706692 cc_score:0.0 bp_score:0.0437027 mf_score:0.0 relationship: child_of NeXO:9573 ! CC: mitochondrial large ribosomal subunit | BP: | MF: [Term] id: NeXO:8162 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.9505734594263 density:0.266666666666667 bootstrap:0.634551369 cc_score:0.0 bp_score:0.0101219 mf_score:0.0 relationship: child_of NeXO:8163 ! CC: | BP: | MF: [Term] id: NeXO:8161 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.88825846775944 density:0.454545454545455 bootstrap:0.57249675 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8162 ! CC: | BP: | MF: [Term] id: NeXO:6975 name: CC: | BP: | MF:water transport def: "CC_def: | BP_def: | MF_def:The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:3.46003217058623 density:0.194444444444444 bootstrap:0.454010378 cc_score:0.0 bp_score:0.0 mf_score:0.140659 relationship: child_of NeXO:7338 ! CC: | BP: | MF: [Term] id: NeXO:8167 name: CC: | BP: | MF:nucleosomal histone binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [NeXO-GO:term] namespace: NeXO comment: robustness:2.04629750342169 density:0.2 bootstrap:0.505951185 cc_score:0.0 bp_score:0.0352893 mf_score:0.139054 relationship: child_of NeXO:8735 ! CC: | BP: | MF: [Term] id: NeXO:8166 name: CC: | BP: | MF:5-aminolevulinate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:6.26248116602686 density:0.666666666666667 bootstrap:0.74908905 cc_score:0.0 bp_score:0.0464675 mf_score:0.13867 relationship: child_of NeXO:9058 ! CC: | BP: | MF: [Term] id: NeXO:8165 name: CC: ESCRT III complex | BP: intralumenal vesicle formation | MF: def: "CC_def: An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. | BP_def: The evagination of the endosome membrane, resulting in the formation of a vesicle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.53436018133366 density:0.833333333333333 bootstrap:0.72432495 cc_score:0.485286 bp_score:0.408938 mf_score:0.0 relationship: child_of NeXO:8738 ! CC: | BP: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | MF: relationship: linked_to NeXO:8239 ! CC: ESCRT I complex | BP: regulation of transcription from RNA polymerase II promoter by glucose | MF: [Term] id: NeXO:6971 name: CC: DASH complex | BP: regulation of microtubule polymerization or depolymerization | MF:microtubule binding def: "CC_def: A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. | BP_def: Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. | MF_def:Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [NeXO-GO:term] namespace: NeXO comment: robustness:10.7666478857353 density:0.857142857142857 bootstrap:0.85910602 cc_score:0.616464 bp_score:0.395812 mf_score:0.290695 relationship: child_of NeXO:8721 ! CC: condensed nuclear chromosome, centromeric region | BP: microtubule polymerization or depolymerization | MF:tubulin binding [Term] id: NeXO:7176 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25619562132032 density:0.0333333333333333 bootstrap:0.60312381 cc_score:0.0 bp_score:0.0409199 mf_score:0.0 relationship: child_of NeXO:8850 ! CC: | BP: | MF: [Term] id: NeXO:6978 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25664675787326 density:1 bootstrap:0.84381844 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8403 ! CC: | BP: | MF: [Term] id: NeXO:6979 name: CC: nuclear exosome (RNase complex) | BP: nuclear polyadenylation-dependent mRNA catabolic process | MF: def: "CC_def: Complex of 3'-5' exoribonucleases found in the nucleus. | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.20723176829321 density:1 bootstrap:0.63842063 cc_score:0.253958 bp_score:0.287586 mf_score:0.0 relationship: child_of NeXO:8241 ! CC: cytoplasmic exosome (RNase complex) | BP: nonfunctional rRNA decay | MF: [Term] id: NeXO:5533 name: CC: | BP: cysteine-type endopeptidase activity | MF:cysteine-type endopeptidase activity def: "CC_def: | BP_def: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. | MF_def:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84440718 cc_score:0.0 bp_score:0.125 mf_score:0.123833 relationship: child_of NeXO:6729 ! CC: | BP: | MF: [Term] id: NeXO:5532 name: CC: | BP: | MF:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.899065542 cc_score:0.0 bp_score:0.0419043 mf_score:0.225244 relationship: child_of NeXO:5994 ! CC: | BP: | MF: [Term] id: NeXO:5531 name: CC: | BP: nicotinamide riboside metabolic process | MF:nicotinic acid riboside kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. | MF_def:Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90728613 cc_score:0.0 bp_score:0.230329 mf_score:0.445412 relationship: child_of NeXO:6092 ! CC: | BP: cobalt ion transport | MF:cobalt ion transport [Term] id: NeXO:5530 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.0243251435179 density:0.333333333333333 bootstrap:0.82973537 cc_score:0.0 bp_score:0.0160936 mf_score:0.0 relationship: child_of NeXO:5787 ! CC: | BP: | MF: [Term] id: NeXO:5537 name: CC: | BP: establishment of protein localization to chromatin | MF: def: "CC_def: | BP_def: The directed movement of a protein to a part of a chromosome that is organized into chromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.32340316 cc_score:0.0 bp_score:0.222444 mf_score:0.0 relationship: child_of NeXO:5744 ! CC: | BP: | MF: [Term] id: NeXO:5536 name: CC: | BP: UMP biosynthetic process | MF:uridine kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. | MF_def:Catalysis of the reaction: ATP + uridine = ADP + UMP." [NeXO-GO:term] namespace: NeXO comment: robustness:3.1505267594209 density:0.666666666666667 bootstrap:0.90456397 cc_score:0.0 bp_score:0.334572 mf_score:0.575395 relationship: child_of NeXO:5698 ! CC: | BP: pyrimidine nucleoside monophosphate biosynthetic process | MF:nucleoside kinase activity [Term] id: NeXO:5535 name: CC: | BP: pyrimidine-containing compound salvage | MF:uracil phosphoribosyltransferase activity def: "CC_def: | BP_def: Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. | MF_def:Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.94820853 cc_score:0.0 bp_score:0.148726 mf_score:0.440283 relationship: child_of NeXO:5536 ! CC: | BP: UMP biosynthetic process | MF:uridine kinase activity [Term] id: NeXO:5534 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84795813 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6527 ! CC: | BP: | MF: [Term] id: NeXO:5538 name: CC: | BP: tryptophanyl-tRNA aminoacylation | MF:tryptophan-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74751074 cc_score:0.0 bp_score:0.282873 mf_score:0.292806 relationship: child_of NeXO:6084 ! CC: | BP: | MF:acetyl-CoA C-acetyltransferase activity [Term] id: NeXO:8342 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.290391874 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8844 ! CC: | BP: glycine hydroxymethyltransferase activity | MF:glycine hydroxymethyltransferase activity [Term] id: NeXO:8765 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27095857201141 density:1 bootstrap:0.854555493 cc_score:0.0 bp_score:0.0141268 mf_score:0.0 relationship: child_of NeXO:9233 ! CC: TRAPP complex | BP: | MF:Rab guanyl-nucleotide exchange factor activity relationship: linked_to NeXO:6984 ! CC: early endosome | BP: early endosome to Golgi transport | MF: relationship: linked_to NeXO:9567 ! CC: | BP: | MF: [Term] id: NeXO:7189 name: CC: | BP: | MF:protein C-terminal leucine carboxyl O-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.07154285443191 density:0.333333333333333 bootstrap:0.458060391 cc_score:0.0 bp_score:0.0815625 mf_score:0.253658 relationship: child_of NeXO:7777 ! CC: | BP: | MF: [Term] id: NeXO:8767 name: CC: | BP: trehalose metabolism in response to heat stress | MF:G-protein coupled receptor activity def: "CC_def: | BP_def: The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. | MF_def:A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9852270902434 density:0.666666666666667 bootstrap:0.359164435 cc_score:0.0 bp_score:0.269851 mf_score:0.136377 relationship: child_of NeXO:9324 ! CC: | BP: chaperone cofactor-dependent protein refolding | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:8766 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.41928009958361 density:1 bootstrap:0.645754642 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9270 ! CC: | BP: | MF: relationship: linked_to NeXO:8807 ! CC: | BP: | MF: relationship: linked_to NeXO:9183 ! CC: | BP: | MF: relationship: linked_to NeXO:8882 ! CC: | BP: | MF: [Term] id: NeXO:8681 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2281843098898 density:0.0398550724637681 bootstrap:0.21730325 cc_score:0.0 bp_score:0.0532536 mf_score:0.0372836 relationship: child_of NeXO:9256 ! CC: | BP: | MF: [Term] id: NeXO:8760 name: CC: endoplasmic reticulum Sec complex | BP: posttranslational protein targeting to membrane, translocation | MF:P-P-bond-hydrolysis-driven protein transmembrane transporter activity def: "CC_def: An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. | BP_def: The process in which a protein translocates through the ER membrane posttranslationally. | MF_def:Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [NeXO-GO:term] namespace: NeXO comment: robustness:4.49421882480414 density:0.8 bootstrap:0.454105753 cc_score:0.565649 bp_score:0.432695 mf_score:0.197895 relationship: child_of NeXO:9528 ! CC: rough endoplasmic reticulum membrane | BP: protein targeting to ER | MF: [Term] id: NeXO:6915 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6182866527297 density:1 bootstrap:0.433943064 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7331 ! CC: | BP: ubiquitin-dependent endocytosis | MF:ubiquitin protein ligase binding [Term] id: NeXO:8762 name: CC: | BP: regulation of fungal-type cell wall biogenesis | MF:UDP-glucose:glycoprotein glucosyltransferase activity def: "CC_def: | BP_def: Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin. | MF_def:Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.485831862 cc_score:0.0 bp_score:0.438553 mf_score:0.439642 relationship: child_of NeXO:9709 ! CC: | BP: | MF: relationship: linked_to NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:7180 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82984249818837 density:1 bootstrap:0.55481637 cc_score:0.0 bp_score:0.0807831 mf_score:0.0 relationship: child_of NeXO:7509 ! CC: | BP: | MF: relationship: linked_to NeXO:6201 ! CC: | BP: | MF: [Term] id: NeXO:7181 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15921787732814 density:0.266666666666667 bootstrap:0.589093085 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8207 ! CC: | BP: | MF: [Term] id: NeXO:7182 name: CC: | BP: sphingolipid catabolic process | MF:ceramidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). | MF_def:Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.75496664449835 density:0.2 bootstrap:0.372142098 cc_score:0.0 bp_score:0.118158 mf_score:0.142122 relationship: child_of NeXO:8029 ! CC: | BP: | MF: [Term] id: NeXO:7183 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.59904045942994 density:0.333333333333333 bootstrap:0.517723609 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7992 ! CC: | BP: proton-transporting ATP synthase complex biogenesis | MF: [Term] id: NeXO:8769 name: CC: mitochondrial respiratory chain complex III | BP: mitochondrial electron transport, ubiquinol to cytochrome c | MF: def: "CC_def: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. | BP_def: The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.2509215924278 density:0.466666666666667 bootstrap:0.539524924 cc_score:0.116048 bp_score:0.112047 mf_score:0.0 relationship: child_of NeXO:9281 ! CC: mitochondrial respiratory chain | BP: mitochondrial ATP synthesis coupled electron transport | MF:ubiquinol-cytochrome-c reductase activity [Term] id: NeXO:8768 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.26123928708008 density:1 bootstrap:0.538479067 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9258 ! CC: SAGA complex | BP: protein deubiquitination | MF:histone acetylation [Term] id: NeXO:8170 name: CC: | BP: | MF:RNA polymerase II transcription factor recruiting transcription factor activity def: "CC_def: | BP_def: | MF_def:The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II." [NeXO-GO:term] namespace: NeXO comment: robustness:9.99762284216169 density:0.861111111111111 bootstrap:0.57354093 cc_score:0.0 bp_score:0.0 mf_score:0.127266 relationship: child_of NeXO:9383 ! CC: | BP: | MF: relationship: linked_to NeXO:9559 ! CC: | BP: | MF:RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Term] id: NeXO:8389 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.40966595 cc_score:0.0 bp_score:0.0684457 mf_score:0.0 relationship: child_of NeXO:9537 ! CC: | BP: tRNA thio-modification | MF: [Term] id: NeXO:8388 name: CC: TRAMP complex | BP: ncRNA polyadenylation | MF:polynucleotide adenylyltransferase activity def: "CC_def: A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. | BP_def: The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation. | MF_def:Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [NeXO-GO:term] namespace: NeXO comment: robustness:7.0008668039796 density:0.8 bootstrap:0.73915097 cc_score:0.544987 bp_score:0.550622 mf_score:0.449336 relationship: child_of NeXO:8993 ! CC: | BP: nuclear polyadenylation-dependent snoRNA catabolic process | MF:adenylyltransferase activity [Term] id: NeXO:8387 name: CC: | BP: negative regulation of transcription termination, DNA-dependent | MF:protein-arginine omega-N asymmetric methyltransferase activity def: "CC_def: | BP_def: Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. | MF_def:Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [NeXO-GO:term] namespace: NeXO comment: robustness:2.01547440761603 density:1 bootstrap:0.67309509 cc_score:0.0 bp_score:0.293919 mf_score:0.442869 relationship: child_of NeXO:9671 ! CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: relationship: linked_to NeXO:8957 ! CC: | BP: protein heterodimerization activity | MF: [Term] id: NeXO:8385 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39515400193286 density:0.0398550724637681 bootstrap:0.251090848 cc_score:0.0 bp_score:0.0155186 mf_score:0.0 relationship: child_of NeXO:9334 ! CC: | BP: | MF: [Term] id: NeXO:8383 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30313669786776 density:0.333333333333333 bootstrap:0.566205816 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8888 ! CC: Pwp2p-containing subcomplex of 90S preribosome | BP: | MF: [Term] id: NeXO:8503 name: CC: | BP: L-cystine transport | MF:L-cystine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of L-cystine from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.59613043528813 density:1 bootstrap:0.42214204 cc_score:0.0 bp_score:0.442768 mf_score:0.440521 relationship: child_of NeXO:8897 ! CC: | BP: | MF:radical SAM enzyme activity relationship: linked_to NeXO:6788 ! CC: | BP: | MF: relationship: linked_to NeXO:8012 ! CC: | BP: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase | MF:deoxyhypusine synthase activity [Term] id: NeXO:5103 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85230149 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5111 ! CC: | BP: | MF: [Term] id: NeXO:8686 name: CC: actomyosin contractile ring | BP: negative regulation of Arp2/3 complex-mediated actin nucleation | MF:myosin II heavy chain binding def: "CC_def: A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. | MF_def:Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [NeXO-GO:term] namespace: NeXO comment: robustness:3.43380724406466 density:0.666666666666667 bootstrap:0.550056652 cc_score:0.16754 bp_score:0.165392 mf_score:0.210129 relationship: child_of NeXO:9026 ! CC: myosin complex | BP: | MF:microfilament motor activity [Term] id: NeXO:8050 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66402751081081 density:0.333333333333333 bootstrap:0.29556697 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8790 ! CC: | BP: | MF: [Term] id: NeXO:8549 name: CC: | BP: poly(A)+ mRNA export from nucleus | MF: def: "CC_def: | BP_def: The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.69328198773804 density:0.666666666666667 bootstrap:0.636327265 cc_score:0.0 bp_score:0.105211 mf_score:0.0901681 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport relationship: linked_to NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: [Term] id: NeXO:8018 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79461431288035 density:0.0879120879120879 bootstrap:0.335305459 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8818 ! CC: | BP: regulation of gluconeogenesis | MF: [Term] id: NeXO:8545 name: CC: | BP: | MF:sterol-transporting ATPase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.91478663689282 density:0.190476190476190 bootstrap:0.5489851 cc_score:0.0 bp_score:0.0 mf_score:0.139244 relationship: child_of NeXO:9724 ! CC: | BP: | MF: [Term] id: NeXO:8544 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.223827183071 density:0.9 bootstrap:0.524616068 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9033 ! CC: | BP: | MF: relationship: linked_to NeXO:8543 ! CC: | BP: | MF: [Term] id: NeXO:8547 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.483619039 cc_score:0.0 bp_score:0.0 mf_score:0.0317288 relationship: child_of NeXO:9130 ! CC: | BP: | MF: [Term] id: NeXO:8546 name: CC: | BP: negative regulation of glycogen catabolic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21635262704863 density:0.666666666666667 bootstrap:0.44766244 cc_score:0.0 bp_score:0.315132 mf_score:0.0613648 relationship: child_of NeXO:9197 ! CC: | BP: | MF: relationship: linked_to NeXO:6968 ! CC: | BP: | MF:polynucleotide 3'-phosphatase activity [Term] id: NeXO:8013 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.221977102 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8347 ! CC: | BP: | MF: relationship: linked_to NeXO:6370 ! CC: | BP: | MF: [Term] id: NeXO:8012 name: CC: | BP: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase | MF:deoxyhypusine synthase activity def: "CC_def: | BP_def: The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+. | MF_def:Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.81929936745136 density:0.666666666666667 bootstrap:0.724361447 cc_score:0.0 bp_score:0.318586 mf_score:0.313687 relationship: child_of NeXO:8632 ! CC: | BP: spermidine metabolic process | MF:pantothenate kinase activity relationship: linked_to NeXO:8897 ! CC: | BP: | MF:radical SAM enzyme activity [Term] id: NeXO:8543 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.74605175898747 density:0.238095238095238 bootstrap:0.371714552 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9014 ! CC: | BP: | MF: [Term] id: NeXO:6572 name: CC: | BP: IMP salvage | MF:hypoxanthine phosphoribosyltransferase activity def: "CC_def: | BP_def: Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. | MF_def:Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.77425044743984 density:0.666666666666667 bootstrap:0.70139759 cc_score:0.0 bp_score:0.274041 mf_score:0.20303 relationship: child_of NeXO:6594 ! CC: | BP: cytosine transport | MF:cytosine transport [Term] id: NeXO:6573 name: CC: | BP: tRNA splicing, via endonucleolytic cleavage and ligation | MF:endoribonuclease activity, producing 3'-phosphomonoesters def: "CC_def: | BP_def: Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. | MF_def:Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [NeXO-GO:term] namespace: NeXO comment: robustness:5.16060331238342 density:0.181818181818182 bootstrap:0.732640283 cc_score:0.0 bp_score:0.177762 mf_score:0.294312 relationship: child_of NeXO:6603 ! CC: | BP: | MF:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: NeXO:6570 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29979570955813 density:0.142857142857143 bootstrap:0.483261607 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7889 ! CC: | BP: | MF: [Term] id: NeXO:7452 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.18420058961867 density:0.07 bootstrap:0.5005128 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8699 ! CC: | BP: | MF: [Term] id: NeXO:6577 name: CC: | BP: peptidyl-histidine methylation, to form tele-methylhistidine | MF:protein-histidine N-methyltransferase activity def: "CC_def: | BP_def: The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.32426109076018 density:0.133333333333333 bootstrap:0.72641014 cc_score:0.0 bp_score:0.18899 mf_score:0.188258 relationship: child_of NeXO:7859 ! CC: | BP: | MF: [Term] id: NeXO:6574 name: CC: | BP: XMP salvage | MF:xanthine phosphoribosyltransferase activity def: "CC_def: | BP_def: Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. | MF_def:Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.07719077370845 density:0.666666666666667 bootstrap:0.86294235 cc_score:0.0 bp_score:0.316992 mf_score:0.314723 relationship: child_of NeXO:6580 ! CC: | BP: purine nucleotide salvage | MF: [Term] id: NeXO:7451 name: CC: | BP: | MF:3',5'-cyclic-AMP phosphodiesterase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.423164783 cc_score:0.0 bp_score:0.0878259 mf_score:0.207357 relationship: child_of NeXO:8186 ! CC: | BP: | MF:cyclic-nucleotide phosphodiesterase activity [Term] id: NeXO:5626 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.43340067 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5720 ! CC: | BP: | MF: [Term] id: NeXO:6578 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.02871905873727 density:0.155555555555556 bootstrap:0.657246381 cc_score:0.0 bp_score:0.0999507 mf_score:0.0 relationship: child_of NeXO:7464 ! CC: | BP: | MF: [Term] id: NeXO:8506 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.64866404139509 density:1 bootstrap:0.732453007 cc_score:0.0 bp_score:0.0410131 mf_score:0.0 relationship: child_of NeXO:9195 ! CC: | BP: regulation of S phase | MF: relationship: linked_to NeXO:9569 ! CC: | BP: termination of RNA polymerase I transcription | MF: [Term] id: NeXO:5622 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.916000743 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6101 ! CC: | BP: | MF: [Term] id: NeXO:5620 name: CC: | BP: trehalose catabolic process | MF:alpha,alpha-trehalase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. | MF_def:Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71135778 cc_score:0.0 bp_score:0.220726 mf_score:0.219542 relationship: child_of NeXO:6504 ! CC: | BP: | MF: [Term] id: NeXO:8493 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.104772354574 density:1 bootstrap:0.734060928 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9222 ! CC: | BP: | MF: relationship: linked_to NeXO:9018 ! CC: | BP: | MF: relationship: linked_to NeXO:9001 ! CC: | BP: activation of Ras GTPase activity | MF: [Term] id: NeXO:8492 name: CC: | BP: regulation of Rab GTPase activity | MF: def: "CC_def: | BP_def: Any process that modulates the activity of a GTPase of the Rab family. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.29509735396455 density:0.333333333333333 bootstrap:0.33961268 cc_score:0.0 bp_score:0.10493 mf_score:0.0 relationship: child_of NeXO:8967 ! CC: | BP: | MF:Ras GTPase binding relationship: linked_to NeXO:8359 ! CC: | BP: | MF:acetyl-CoA C-acyltransferase activity [Term] id: NeXO:7696 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28660623505474 density:1 bootstrap:0.86637241 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9183 ! CC: | BP: | MF: relationship: linked_to NeXO:9270 ! CC: | BP: | MF: [Term] id: NeXO:7697 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.701683152333516 density:0.0476190476190476 bootstrap:0.163338605 cc_score:0.0 bp_score:0.0362451 mf_score:0.0 relationship: child_of NeXO:8267 ! CC: | BP: | MF: [Term] id: NeXO:8497 name: CC: | BP: gene silencing by RNA | MF:histone deacetylase activity (H3-K16 specific) def: "CC_def: | BP_def: Any process in which RNA molecules inactivate expression of target genes. | MF_def:Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 16) + H2O = histone H3 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.19771594011905 density:0.2 bootstrap:0.402282267 cc_score:0.097885 bp_score:0.383271 mf_score:0.186287 relationship: child_of NeXO:9284 ! CC: | BP: protein deacetylation | MF:histone deacetylase activity [Term] id: NeXO:8496 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08283350399406 density:0.666666666666667 bootstrap:0.443359212 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8789 ! CC: transverse filament | BP: synaptonemal complex assembly | MF: [Term] id: NeXO:7692 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70722266298923 density:0.0714285714285714 bootstrap:0.471880991 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9574 ! CC: mitochondrial small ribosomal subunit | BP: | MF: [Term] id: NeXO:8494 name: CC: DSIF complex | BP: | MF: def: "CC_def: A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32554216912147 density:1 bootstrap:0.89612849 cc_score:0.879694 bp_score:0.0566267 mf_score:0.0 relationship: child_of NeXO:9677 ! CC: | BP: | MF: relationship: linked_to NeXO:8870 ! CC: | BP: regulation of transcription-coupled nucleotide-excision repair | MF: relationship: linked_to NeXO:8370 ! CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding relationship: linked_to NeXO:8753 ! CC: | BP: negative regulation of DNA damage checkpoint | MF: [Term] id: NeXO:8499 name: CC: ESCRT-0 complex | BP: protein retention in Golgi apparatus | MF: def: "CC_def: A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals. | BP_def: The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16726018074985 density:1 bootstrap:0.77829448 cc_score:0.292538 bp_score:0.163635 mf_score:0.0392136 relationship: child_of NeXO:9322 ! CC: | BP: cell wall chitin catabolic process | MF: relationship: linked_to NeXO:9015 ! CC: | BP: Golgi vesicle fusion to target membrane | MF: relationship: linked_to NeXO:6523 ! CC: | BP: late endosome to vacuole transport via multivesicular body sorting pathway | MF: relationship: linked_to NeXO:7770 ! CC: | BP: | MF: [Term] id: NeXO:8498 name: CC: MutSbeta complex | BP: removal of nonhomologous ends | MF:double-strand/single-strand DNA junction binding def: "CC_def: A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. | BP_def: The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. | MF_def:Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7265575014448 density:1 bootstrap:0.493951081 cc_score:0.896191 bp_score:0.303886 mf_score:0.888744 relationship: child_of NeXO:9266 ! CC: mismatch repair complex | BP: meiotic mismatch repair | MF:mismatched DNA binding relationship: linked_to NeXO:8041 ! CC: MutLalpha complex | BP: meiotic heteroduplex formation | MF:dinucleotide insertion or deletion binding relationship: linked_to NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:7512 ! CC: chiasma | BP: | MF: relationship: linked_to NeXO:9180 ! CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: [Term] id: NeXO:7699 name: CC: | BP: L-serine catabolic process | MF:L-threonine ammonia-lyase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. | MF_def:Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.410789334 cc_score:0.0 bp_score:0.316484 mf_score:0.235537 relationship: child_of NeXO:8369 ! CC: | BP: | MF:UDP-N-acetylglucosamine diphosphorylase activity [Term] id: NeXO:8081 name: CC: | BP: | MF:rRNA (guanine) methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9271123105222 density:0.333333333333333 bootstrap:0.75195719 cc_score:0.0 bp_score:0.0165425 mf_score:0.165614 relationship: child_of NeXO:8786 ! CC: | BP: | MF: [Term] id: NeXO:5994 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.11863715573157 density:0.666666666666667 bootstrap:0.88634467 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6168 ! CC: endoplasmic reticulum lumen | BP: cell redox homeostasis | MF:protein disulfide isomerase activity [Term] id: NeXO:5997 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5648773013783 density:0.5 bootstrap:0.84078885 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6728 ! CC: | BP: | MF: [Term] id: NeXO:5996 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07663064572969 density:0.333333333333333 bootstrap:0.87316754 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6728 ! CC: | BP: | MF: [Term] id: NeXO:5991 name: CC: | BP: phosphate transport | MF:phosphate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.22452495188955 density:0.133333333333333 bootstrap:0.665405884 cc_score:0.0 bp_score:0.171183 mf_score:0.245461 relationship: child_of NeXO:6214 ! CC: | BP: | MF:anion transmembrane transporter activity [Term] id: NeXO:5990 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33333690286063 density:0.2 bootstrap:0.65784862 cc_score:0.0 bp_score:0.0 mf_score:0.0903019 relationship: child_of NeXO:7151 ! CC: | BP: | MF: [Term] id: NeXO:5993 name: CC: | BP: | MF:allantoicase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.792935207 cc_score:0.0 bp_score:0.0 mf_score:0.44268 relationship: child_of NeXO:7253 ! CC: | BP: | MF: [Term] id: NeXO:5992 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.27624426179573 density:0.1 bootstrap:0.435137116 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6608 ! CC: | BP: | MF: [Term] id: NeXO:5077 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.34840649141146 density:1 bootstrap:0.91383627 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5803 ! CC: alpha-glucosidase II complex | BP: | MF: [Term] id: NeXO:5999 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.99392727775914 density:1 bootstrap:0.8810458 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6000 ! CC: | BP: | MF: [Term] id: NeXO:5998 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01460215167978 density:0.333333333333333 bootstrap:0.821783944 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6226 ! CC: | BP: budding cell apical bud growth | MF: [Term] id: NeXO:6536 name: CC: | BP: magnesium ion transport | MF:magnesium ion transport def: "CC_def: | BP_def: The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:2.13656506424465 density:1 bootstrap:0.75640448 cc_score:0.0 bp_score:0.463413 mf_score:0.383333 relationship: child_of NeXO:6537 ! CC: | BP: lipoate biosynthetic process | MF:S-adenosylmethionine transmembrane transporter activity [Term] id: NeXO:5662 name: CC: | BP: inactivation of MAPK activity involved in cell wall biogenesis | MF: def: "CC_def: | BP_def: Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81836358031435 density:0.333333333333333 bootstrap:0.66948448 cc_score:0.0 bp_score:0.161884 mf_score:0.0 relationship: child_of NeXO:6603 ! CC: | BP: | MF:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: NeXO:6534 name: CC: | BP: phosphatidylglycerol biosynthetic process | MF:short-chain carboxylesterase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. | MF_def:Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58269226180119 density:0.166666666666667 bootstrap:0.589497825 cc_score:0.0 bp_score:0.121925 mf_score:0.164199 relationship: child_of NeXO:7867 ! CC: | BP: deoxyribonucleotide metabolic process | MF: [Term] id: NeXO:7522 name: CC: | BP: regulation of mating type switching | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.712351383 cc_score:0.0 bp_score:0.100175 mf_score:0.0 relationship: child_of NeXO:9074 ! CC: | BP: | MF: [Term] id: NeXO:7520 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69791197082341 density:0.3 bootstrap:0.54603231 cc_score:0.0 bp_score:0.0 mf_score:0.0664243 relationship: child_of NeXO:8007 ! CC: | BP: | MF: [Term] id: NeXO:7521 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.16812308787415 density:0.333333333333333 bootstrap:0.276284347 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8277 ! CC: | BP: | MF: relationship: linked_to NeXO:6167 ! CC: | BP: | MF: [Term] id: NeXO:7526 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.47952073406004 density:1 bootstrap:0.82918171 cc_score:0.0 bp_score:0.0567378 mf_score:0.0 relationship: child_of NeXO:8610 ! CC: | BP: | MF: [Term] id: NeXO:7527 name: CC: | BP: U1 snRNA 3'-end processing | MF: def: "CC_def: | BP_def: Any process involved in forming the mature 3' end of a U1 snRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82626974033134 density:1 bootstrap:0.552651933 cc_score:0.0 bp_score:0.453465 mf_score:0.0 relationship: child_of NeXO:9449 ! CC: exosome (RNase complex) | BP: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9317 ! CC: | BP: | MF: relationship: linked_to NeXO:8576 ! CC: | BP: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription | MF:3'-5'-exoribonuclease activity [Term] id: NeXO:7525 name: CC: | BP: hypoxanthine salvage | MF: def: "CC_def: | BP_def: Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6494984896695 density:0.0952380952380952 bootstrap:0.402895086 cc_score:0.0 bp_score:0.122104 mf_score:0.0 relationship: child_of NeXO:8572 ! CC: | BP: purine base biosynthetic process | MF: [Term] id: NeXO:6929 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.29152806725027 density:1 bootstrap:0.59840237 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7310 ! CC: | BP: | MF: [Term] id: NeXO:7529 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.08251651116851 density:0.333333333333333 bootstrap:0.544468957 cc_score:0.0 bp_score:0.032189 mf_score:0.0 relationship: child_of NeXO:8249 ! CC: | BP: | MF: [Term] id: NeXO:6533 name: CC: | BP: medium-chain fatty acid catabolic process | MF:alcohol O-butanoyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons. | MF_def:Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [NeXO-GO:term] namespace: NeXO comment: robustness:1.87934220858449 density:1 bootstrap:0.585239435 cc_score:0.0 bp_score:0.29489 mf_score:0.439196 relationship: child_of NeXO:6534 ! CC: | BP: phosphatidylglycerol biosynthetic process | MF:short-chain carboxylesterase activity [Term] id: NeXO:6530 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.425784979 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6961 ! CC: | BP: | MF: [Term] id: NeXO:8296 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.67162928735924 density:1 bootstrap:0.463022174 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8807 ! CC: | BP: | MF: relationship: linked_to NeXO:8780 ! CC: Golgi transport complex | BP: intra-Golgi vesicle-mediated transport | MF: relationship: linked_to NeXO:6498 ! CC: | BP: negative regulation of lipid biosynthetic process | MF: [Term] id: NeXO:6143 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90670401 cc_score:0.0 bp_score:0.0149019 mf_score:0.0 relationship: child_of NeXO:6144 ! CC: | BP: mitochondrial respiratory chain complex III assembly | MF:ribosome binding [Term] id: NeXO:6142 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.54588723894087 density:0.642857142857143 bootstrap:0.617118838 cc_score:0.0 bp_score:0.0504852 mf_score:0.0 relationship: child_of NeXO:6704 ! CC: nucleolar ribonuclease P complex | BP: intronic box C/D snoRNA processing | MF:ribonuclease P activity [Term] id: NeXO:6141 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.58228077978781 density:0.714285714285714 bootstrap:0.391281266 cc_score:0.0 bp_score:0.028006 mf_score:0.0 relationship: child_of NeXO:6142 ! CC: | BP: | MF: [Term] id: NeXO:6140 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.52491886450271 density:0.6 bootstrap:0.446942103 cc_score:0.0 bp_score:0.0146151 mf_score:0.0 relationship: child_of NeXO:6141 ! CC: | BP: | MF: [Term] id: NeXO:6147 name: CC: | BP: mitochondrial DNA repair | MF:guanine/thymine mispair binding def: "CC_def: | BP_def: The process of restoring mitochondrial DNA after damage. | MF_def:Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80448606 cc_score:0.0 bp_score:0.441648 mf_score:0.234527 relationship: child_of NeXO:7512 ! CC: chiasma | BP: | MF: [Term] id: NeXO:6146 name: CC: | BP: cytochrome c-heme linkage | MF:ubiquinone binding def: "CC_def: | BP_def: The linkage of cytochromes and other heme proteins to heme. | MF_def:Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78862991 cc_score:0.0 bp_score:0.229979 mf_score:0.442969 relationship: child_of NeXO:6467 ! CC: | BP: cytochrome complex assembly | MF: [Term] id: NeXO:6144 name: CC: | BP: mitochondrial respiratory chain complex III assembly | MF:ribosome binding def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. | MF_def:Interacting selectively and non-covalently with any part of a ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:3.11162272750377 density:0.666666666666667 bootstrap:0.882362027 cc_score:0.0 bp_score:0.409632 mf_score:0.10864 relationship: child_of NeXO:6467 ! CC: | BP: cytochrome complex assembly | MF: [Term] id: NeXO:6149 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17368687287623 density:1 bootstrap:0.78291716 cc_score:0.0 bp_score:0.0 mf_score:0.0749601 relationship: child_of NeXO:6183 ! CC: | BP: nicotinate nucleotide salvage | MF:nicotinamide mononucleotide transmembrane transporter activity [Term] id: NeXO:6927 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.772983383442036 density:0.0357142857142857 bootstrap:0.21846797 cc_score:0.0 bp_score:0.0151575 mf_score:0.0 relationship: child_of NeXO:7981 ! CC: | BP: | MF: [Term] id: NeXO:6781 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.348080855 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7054 ! CC: | BP: | MF: [Term] id: NeXO:6783 name: CC: | BP: GO:0035965 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49519452 cc_score:0.0 bp_score:0.152524 mf_score:0.0 relationship: child_of NeXO:7712 ! CC: | BP: | MF: [Term] id: NeXO:6782 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.49179907459993 density:0.3 bootstrap:0.465788575 cc_score:0.0 bp_score:0.0476523 mf_score:0.0792842 relationship: child_of NeXO:7184 ! CC: | BP: | MF: [Term] id: NeXO:6785 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.568280248 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7581 ! CC: | BP: | MF: relationship: linked_to NeXO:9471 ! CC: | BP: lipid tube assembly | MF: [Term] id: NeXO:6784 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.504673198 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7496 ! CC: | BP: | MF: [Term] id: NeXO:6787 name: CC: | BP: negative regulation of transcription from RNA polymerase III promoter | MF:RNA polymerase III core binding def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter. | MF_def:Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74947164 cc_score:0.0 bp_score:0.439946 mf_score:0.295735 relationship: child_of NeXO:8673 ! CC: | BP: termination of RNA polymerase III transcription | MF: relationship: linked_to NeXO:8054 ! CC: | BP: | MF: [Term] id: NeXO:6788 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.551364725 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8174 ! CC: | BP: | MF: [Term] id: NeXO:6920 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.02587919972566 density:1 bootstrap:0.71153937 cc_score:0.0651253 bp_score:0.0400734 mf_score:0.0 relationship: child_of NeXO:6921 ! CC: | BP: mitotic spindle organization in nucleus | MF: [Term] id: NeXO:5847 name: CC: | BP: | MF:oligopeptide transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of oligopeptides into, out of or within a cell, or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96409228848296 density:0.333333333333333 bootstrap:0.78109318 cc_score:0.0 bp_score:0.0638831 mf_score:0.104915 relationship: child_of NeXO:7028 ! CC: | BP: phosphatidylserine catabolic process | MF: [Term] id: NeXO:5846 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99588107182493 density:1 bootstrap:0.66007178 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5847 ! CC: | BP: | MF:oligopeptide transporter activity [Term] id: NeXO:5845 name: CC: | BP: mitochondrial pyruvate transport | MF:pyruvate secondary active transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion. | MF_def:Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76710763 cc_score:0.0 bp_score:0.446716 mf_score:0.441443 relationship: child_of NeXO:7143 ! CC: | BP: potassium ion import | MF: [Term] id: NeXO:5844 name: CC: mitochondrial inner membrane peptidase complex | BP: | MF: def: "CC_def: Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06610868300539 density:0.333333333333333 bootstrap:0.86434155 cc_score:0.423236 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6973 ! CC: | BP: ascospore-type prospore membrane assembly | MF: [Term] id: NeXO:5843 name: CC: | BP: spore membrane bending pathway | MF: def: "CC_def: | BP_def: The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91435698 cc_score:0.0 bp_score:0.221321 mf_score:0.0466878 relationship: child_of NeXO:5844 ! CC: mitochondrial inner membrane peptidase complex | BP: | MF: [Term] id: NeXO:6923 name: CC: | BP: maltose catabolic process | MF:maltose alpha-glucosidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose). | MF_def:Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.851061562 cc_score:0.0 bp_score:0.147787 mf_score:0.29572 relationship: child_of NeXO:7520 ! CC: | BP: | MF: [Term] id: NeXO:8176 name: CC: | BP: transcription termination, DNA-dependent | MF: def: "CC_def: | BP_def: The cellular process that completes DNA-dependent transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.93536558635461 density:0.4 bootstrap:0.458204566 cc_score:0.0 bp_score:0.11454 mf_score:0.0 relationship: child_of NeXO:9166 ! CC: | BP: | MF: [Term] id: NeXO:5840 name: CC: | BP: response to zinc ion | MF:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. | MF_def:Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81502867 cc_score:0.0 bp_score:0.293462 mf_score:0.44271 relationship: child_of NeXO:6207 ! CC: | BP: | MF:S-methyltransferase activity [Term] id: NeXO:8115 name: CC: | BP: CDP-choline pathway | MF:choline-phosphate cytidylyltransferase activity def: "CC_def: | BP_def: The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. | MF_def:Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.404142849 cc_score:0.0 bp_score:0.178902 mf_score:0.443519 relationship: child_of NeXO:8157 ! CC: | BP: | MF:cytidylyltransferase activity relationship: linked_to NeXO:7691 ! CC: | BP: | MF: [Term] id: NeXO:5849 name: CC: | BP: negative regulation of glycogen metabolic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17876094735105 density:1 bootstrap:0.78657658 cc_score:0.0 bp_score:0.113572 mf_score:0.0 relationship: child_of NeXO:6052 ! CC: cyclin-dependent protein kinase holoenzyme complex | BP: regulation of autophagy | MF:protein kinase binding [Term] id: NeXO:5848 name: CC: | BP: asparagine biosynthetic process | MF:asparagine synthase (glutamine-hydrolyzing) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. | MF_def:Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.22394561286699 density:1 bootstrap:0.81954003 cc_score:0.0 bp_score:0.444728 mf_score:0.589562 relationship: child_of NeXO:6053 ! CC: | BP: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | MF: [Term] id: NeXO:7713 name: CC: | BP: pyrimidine nucleoside triphosphate metabolic process | MF:poly(A) RNA binding def: "CC_def: | BP_def: The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. | MF_def:Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.277793392 cc_score:0.0 bp_score:0.113701 mf_score:0.10076 relationship: child_of NeXO:8312 ! CC: | BP: | MF: [Term] id: NeXO:5528 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16951018916907 density:1 bootstrap:0.77991134 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5530 ! CC: | BP: | MF: [Term] id: NeXO:7712 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.392251309 cc_score:0.0 bp_score:0.0735457 mf_score:0.0 relationship: child_of NeXO:8634 ! CC: | BP: | MF: [Term] id: NeXO:8689 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.49806712123903 density:0.3 bootstrap:0.468134877 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9219 ! CC: | BP: | MF: relationship: linked_to NeXO:9402 ! CC: | BP: | MF: [Term] id: NeXO:9763 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.4445040855491 density:0.324110671936759 bootstrap:0.533291448 cc_score:0.0 bp_score:0.0195336 mf_score:0.0 relationship: child_of NeXO:9937 ! CC: | BP: vacuole organization | MF: [Term] id: NeXO:9049 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.37987490130314 density:0.0474308300395257 bootstrap:0.211290373 cc_score:0.0 bp_score:0.034795 mf_score:0.0 relationship: child_of NeXO:9562 ! CC: | BP: | MF: [Term] id: NeXO:9048 name: CC: | BP: spindle assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.413392377 cc_score:0.0 bp_score:0.147603 mf_score:0.0 relationship: child_of NeXO:9148 ! CC: | BP: spindle pole body duplication in nuclear envelope | MF: relationship: linked_to NeXO:9671 ! CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: relationship: linked_to NeXO:7285 ! CC: intermediate layer of spindle pole body | BP: | MF: relationship: linked_to NeXO:8201 ! CC: | BP: | MF: [Term] id: NeXO:9249 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86961825902436 density:1 bootstrap:0.5791989 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9484 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: [Term] id: NeXO:9248 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.51519310302412 density:0.119047619047619 bootstrap:0.264337887 cc_score:0.0 bp_score:0.012495 mf_score:0.0 relationship: child_of NeXO:9653 ! CC: | BP: purine nucleoside monophosphate biosynthetic process | MF: [Term] id: NeXO:9539 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.10423265784098 density:0.80952380952381 bootstrap:0.396772877 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9635 ! CC: | BP: | MF: relationship: linked_to NeXO:9793 ! CC: | BP: | MF: relationship: linked_to NeXO:9507 ! CC: | BP: | MF: [Term] id: NeXO:9538 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.51992490729373 density:1 bootstrap:0.70436242 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9768 ! CC: | BP: | MF: relationship: linked_to NeXO:9503 ! CC: | BP: | MF: relationship: linked_to NeXO:9506 ! CC: | BP: | MF: relationship: linked_to NeXO:9232 ! CC: | BP: | MF: [Term] id: NeXO:9241 name: CC: | BP: | MF:regulation of translational fidelity def: "CC_def: | BP_def: | MF_def:Any process that modulates the ability of the translational apparatus to interpret the genetic code." [NeXO-GO:term] namespace: NeXO comment: robustness:1.3999073698009 density:1 bootstrap:0.32472853 cc_score:0.0 bp_score:0.0 mf_score:0.145833 relationship: child_of NeXO:9286 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: [Term] id: NeXO:9535 name: CC: | BP: box H/ACA snoRNA 3'-end processing | MF: def: "CC_def: | BP_def: Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.80559165178136 density:1 bootstrap:0.54020789 cc_score:0.0 bp_score:0.438527 mf_score:0.0318663 relationship: child_of NeXO:9826 ! CC: | BP: regulation of telomerase activity | MF: relationship: linked_to NeXO:9371 ! CC: | BP: | MF: relationship: linked_to NeXO:9375 ! CC: | BP: negative regulation of translation in response to stress | MF: relationship: linked_to NeXO:9251 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding relationship: linked_to NeXO:8693 ! CC: | BP: | MF: [Term] id: NeXO:9534 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.0952653330227 density:1 bootstrap:0.67329891 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9769 ! CC: | BP: ribosomal large subunit assembly | MF: [Term] id: NeXO:9533 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35738660095305 density:1 bootstrap:0.6225882 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9891 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: relationship: linked_to NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:9084 ! CC: | BP: regulation of histone H3-K36 methylation | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:9561 ! CC: | BP: | MF: relationship: linked_to NeXO:9516 ! CC: | BP: | MF: relationship: linked_to NeXO:8563 ! CC: | BP: | MF: relationship: linked_to NeXO:9621 ! CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: [Term] id: NeXO:9532 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.9730626184688 density:0.458333333333333 bootstrap:0.568897992 cc_score:0.0785221 bp_score:0.0546127 mf_score:0.0 relationship: child_of NeXO:9985 ! CC: U2-type spliceosomal complex | BP: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | MF: [Term] id: NeXO:9531 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.47518808572734 density:0.272727272727273 bootstrap:0.27707432 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9844 ! CC: | BP: | MF:Ras GTPase activator activity [Term] id: NeXO:9530 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.79764217209729 density:0.607142857142857 bootstrap:0.538916584 cc_score:0.0 bp_score:0.0794919 mf_score:0.0 relationship: child_of NeXO:9862 ! CC: | BP: chitin biosynthetic process | MF: [Term] id: NeXO:7852 name: CC: | BP: protein thiol-disulfide exchange | MF:thiol oxidase activity def: "CC_def: | BP_def: Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond, according to the reaction RS-SR + R'SH = R'S-SR + RSH. | MF_def:Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:1.84710475182395 density:1 bootstrap:0.56533373 cc_score:0.0 bp_score:0.291956 mf_score:0.214481 relationship: child_of NeXO:8413 ! CC: | BP: | MF: [Term] id: NeXO:7853 name: CC: | BP: | MF:MAP kinase kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33320153780501 density:1 bootstrap:0.90204116 cc_score:0.0 bp_score:0.0972222 mf_score:0.448242 relationship: child_of NeXO:8830 ! CC: | BP: regulation of initiation of mating projection growth | MF:protein serine/threonine/tyrosine kinase activity relationship: linked_to NeXO:7902 ! CC: | BP: | MF: [Term] id: NeXO:7850 name: CC: | BP: regulation of mitochondrial translation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94003098133392 density:0.107142857142857 bootstrap:0.374290693 cc_score:0.0 bp_score:0.11406 mf_score:0.0 relationship: child_of NeXO:8574 ! CC: | BP: respiratory chain complex IV assembly | MF: [Term] id: NeXO:7851 name: CC: | BP: GO:0035959 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.48555966363075 density:1 bootstrap:0.365680704 cc_score:0.0 bp_score:0.438872 mf_score:0.0389618 relationship: child_of NeXO:8474 ! CC: | BP: | MF: [Term] id: NeXO:7856 name: CC: | BP: | MF:polynucleotide 5'-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.206583862 cc_score:0.0 bp_score:0.0 mf_score:0.234481 relationship: child_of NeXO:8365 ! CC: | BP: RNA capping | MF: [Term] id: NeXO:7857 name: CC: | BP: | MF:histone demethylase activity (H3-K4 specific) def: "CC_def: | BP_def: | MF_def:Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.425601572 cc_score:0.0 bp_score:0.0 mf_score:0.301005 relationship: child_of NeXO:7957 ! CC: | BP: | MF:tRNA (cytosine) methyltransferase activity relationship: linked_to NeXO:9350 ! CC: | BP: | MF: relationship: linked_to NeXO:9112 ! CC: tight junction | BP: | MF: [Term] id: NeXO:7854 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87448625833775 density:0.0757575757575758 bootstrap:0.245863593 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8829 ! CC: | BP: | MF: [Term] id: NeXO:9042 name: CC: | BP: branched chain family amino acid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.35163521038725 density:0.0727272727272727 bootstrap:0.158890207 cc_score:0.0 bp_score:0.10146 mf_score:0.0780517 relationship: child_of NeXO:9870 ! CC: | BP: glucose catabolic process | MF: [Term] id: NeXO:7859 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.83539627539019 density:0.0522875816993464 bootstrap:0.420115358 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8971 ! CC: | BP: | MF: [Term] id: NeXO:9468 name: CC: CCR4-NOT complex | BP: | MF: def: "CC_def: A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.90616571259968 density:0.352380952380952 bootstrap:0.302153306 cc_score:0.375712 bp_score:0.099901 mf_score:0.0456297 relationship: child_of NeXO:9874 ! CC: | BP: | MF: [Term] id: NeXO:6948 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.11998729584621 density:0.666666666666667 bootstrap:0.88711228 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8679 ! CC: | BP: | MF: relationship: linked_to NeXO:9251 ! CC: | BP: | MF: [Term] id: NeXO:5494 name: CC: | BP: L-phenylalanine catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90945144242575 density:0.166666666666667 bootstrap:0.85803793 cc_score:0.0 bp_score:0.233734 mf_score:0.0 relationship: child_of NeXO:6374 ! CC: | BP: regulation of thiamine biosynthetic process | MF:thiamine pyrophosphate binding [Term] id: NeXO:9403 name: CC: eukaryotic translation initiation factor 2B complex | BP: regulation of translational initiation | MF: def: "CC_def: A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. | BP_def: Any process that modulates the frequency, rate or extent of translational initiation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.0655226990416 density:1 bootstrap:0.72456125 cc_score:0.547154 bp_score:0.21742 mf_score:0.0934957 relationship: child_of NeXO:9442 ! CC: guanyl-nucleotide exchange factor complex | BP: | MF: [Term] id: NeXO:9402 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.77705869992397 density:0.866666666666667 bootstrap:0.309183407 cc_score:0.0 bp_score:0.0896031 mf_score:0.0 relationship: child_of NeXO:9518 ! CC: eukaryotic translation initiation factor 3 complex | BP: translation reinitiation | MF: [Term] id: NeXO:7982 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5970171619226 density:0.5 bootstrap:0.85601779 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8999 ! CC: | BP: negative regulation of histone H3-K9 acetylation | MF:histone methyltransferase activity (H3-K36 specific) [Term] id: NeXO:7983 name: CC: | BP: DNA fragmentation involved in apoptotic nuclear change | MF:3'-5'-exodeoxyribonuclease activity def: "CC_def: | BP_def: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.79162535875219 density:1 bootstrap:0.53188317 cc_score:0.0 bp_score:0.439776 mf_score:0.135195 relationship: child_of NeXO:8141 ! CC: | BP: | MF:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity [Term] id: NeXO:9407 name: CC: mRNA cleavage and polyadenylation specificity factor complex | BP: termination of RNA polymerase II transcription | MF: def: "CC_def: A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. | BP_def: The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.5670626682034 density:1 bootstrap:0.81317789 cc_score:0.708928 bp_score:0.172729 mf_score:0.0 relationship: child_of NeXO:9755 ! CC: mRNA cleavage factor complex | BP: mRNA polyadenylation | MF: [Term] id: NeXO:7986 name: CC: vacuolar proton-transporting V-type ATPase, V1 domain | BP: intein-mediated protein splicing | MF: def: "CC_def: The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. | BP_def: The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.25910623301211 density:1 bootstrap:0.5866718 cc_score:0.348845 bp_score:0.219733 mf_score:0.0 relationship: child_of NeXO:8724 ! CC: vacuolar proton-transporting V-type ATPase complex | BP: ATP hydrolysis coupled proton transport | MF:proton transport relationship: linked_to NeXO:8571 ! CC: RAVE complex | BP: early endosome to late endosome transport | MF: relationship: linked_to NeXO:7541 ! CC: proton-transporting two-sector ATPase complex, catalytic domain | BP: | MF: relationship: linked_to NeXO:7263 ! CC: | BP: vacuolar proton-transporting V-type ATPase complex assembly | MF: relationship: linked_to NeXO:7769 ! CC: | BP: proton-transporting two-sector ATPase complex assembly | MF: [Term] id: NeXO:7987 name: CC: | BP: kinetochore assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31887950463096 density:1 bootstrap:0.89100104 cc_score:0.0 bp_score:0.146226 mf_score:0.0 relationship: child_of NeXO:9652 ! CC: SCF ubiquitin ligase complex | BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: relationship: linked_to NeXO:9340 ! CC: | BP: | MF: relationship: linked_to NeXO:5446 ! CC: | BP: | MF: relationship: linked_to NeXO:6549 ! CC: | BP: protein neddylation | MF:small protein activating enzyme activity relationship: linked_to NeXO:5484 ! CC: | BP: | MF: relationship: linked_to NeXO:7400 ! CC: | BP: negative regulation of protein ubiquitination | MF: [Term] id: NeXO:6363 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.99560767093022 density:0.666666666666667 bootstrap:0.817791906 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6364 ! CC: | BP: | MF: [Term] id: NeXO:7989 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92277893606401 density:1 bootstrap:0.61260503 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8379 ! CC: | BP: | MF: relationship: linked_to NeXO:8028 ! CC: | BP: | MF: [Term] id: NeXO:6361 name: CC: | BP: negative regulation of phospholipid biosynthetic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.12028448705402 density:0.666666666666667 bootstrap:0.88728129 cc_score:0.0 bp_score:0.427527 mf_score:0.0 relationship: child_of NeXO:6498 ! CC: | BP: negative regulation of lipid biosynthetic process | MF: [Term] id: NeXO:6360 name: CC: | BP: nuclear envelope organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.892904833 cc_score:0.0 bp_score:0.110489 mf_score:0.0 relationship: child_of NeXO:6361 ! CC: | BP: negative regulation of phospholipid biosynthetic process | MF: [Term] id: NeXO:6367 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.69031311847516 density:1 bootstrap:0.473430432 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6370 ! CC: | BP: | MF: [Term] id: NeXO:6366 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.584949407 cc_score:0.0 bp_score:0.0785889 mf_score:0.0 relationship: child_of NeXO:6959 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:9748 ! CC: | BP: | MF: [Term] id: NeXO:6365 name: CC: | BP: chaperone-mediated protein complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23806014784491 density:1 bootstrap:0.829975657 cc_score:0.0 bp_score:0.351254 mf_score:0.0 relationship: child_of NeXO:7942 ! CC: | BP: | MF: relationship: linked_to NeXO:8827 ! CC: | BP: | MF: [Term] id: NeXO:6364 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90715449338625 density:0.266666666666667 bootstrap:0.49883968 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6993 ! CC: | BP: | MF: [Term] id: NeXO:9335 name: CC: Noc1p-Noc2p complex | BP: | MF: def: "CC_def: A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75530680630107 density:1 bootstrap:0.510537821 cc_score:0.294123 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9504 ! CC: Noc complex | BP: | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: relationship: linked_to NeXO:9533 ! CC: | BP: | MF: relationship: linked_to NeXO:8953 ! CC: | BP: | MF: relationship: linked_to NeXO:9567 ! CC: | BP: | MF: [Term] id: NeXO:9334 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.21317095366307 density:0.0457142857142857 bootstrap:0.152775832 cc_score:0.0 bp_score:0.0472022 mf_score:0.0632914 relationship: child_of NeXO:9720 ! CC: | BP: | MF: [Term] id: NeXO:9337 name: CC: | BP: cysteine metabolic process | MF:methionine biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. | MF_def:The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:4.65304683732406 density:0.129870129870130 bootstrap:0.228179818 cc_score:0.0 bp_score:0.180498 mf_score:0.174991 relationship: child_of NeXO:9712 ! CC: | BP: sulfur amino acid biosynthetic process | MF: [Term] id: NeXO:9330 name: CC: | BP: negative regulation of G1/S transition of mitotic cell cycle | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.42322293146832 density:0.666666666666667 bootstrap:0.53513047 cc_score:0.0 bp_score:0.271026 mf_score:0.0223764 relationship: child_of NeXO:9624 ! CC: | BP: negative regulation of transcription during meiosis | MF: relationship: linked_to NeXO:8219 ! CC: | BP: negative regulation of transcription from RNA polymerase I promoter | MF: relationship: linked_to NeXO:8690 ! CC: | BP: | MF: [Term] id: NeXO:9333 name: CC: | BP: osmosensory signaling pathway | MF: def: "CC_def: | BP_def: The series of molecular signals initiated in response to osmotic change. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.8007619551804 density:0.166666666666667 bootstrap:0.486274455 cc_score:0.0 bp_score:0.24635 mf_score:0.0 relationship: child_of NeXO:9818 ! CC: | BP: cellular response to osmotic stress | MF: [Term] id: NeXO:9332 name: CC: | BP: | MF:ATPase inhibitor activity def: "CC_def: | BP_def: | MF_def:Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.93293269934604 density:0.5 bootstrap:0.348885166 cc_score:0.0 bp_score:0.0394392 mf_score:0.160851 relationship: child_of NeXO:9753 ! CC: | BP: | MF: [Term] id: NeXO:5739 name: CC: | BP: aromatic amino acid family biosynthetic process, prephenate pathway | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.46657225420213 density:0.2 bootstrap:0.73512087 cc_score:0.0 bp_score:0.143485 mf_score:0.0 relationship: child_of NeXO:6546 ! CC: | BP: regulation of transcription, mating-type specific | MF: [Term] id: NeXO:9338 name: CC: SNARE complex | BP: ascospore-type prospore formation | MF:phosphatidic acid binding def: "CC_def: A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. | BP_def: During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane. | MF_def:Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [NeXO-GO:term] namespace: NeXO comment: robustness:9.69531087364584 density:1 bootstrap:0.74165495 cc_score:0.162269 bp_score:0.147758 mf_score:0.176996 relationship: child_of NeXO:9844 ! CC: | BP: | MF:Ras GTPase activator activity [Term] id: NeXO:9629 name: CC: ER ubiquitin ligase complex | BP: ER-associated protein catabolic process | MF: def: "CC_def: A ubiquitin ligase complex found in the ER. | BP_def: The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.29877533821195 density:0.490909090909091 bootstrap:0.312050335 cc_score:0.289626 bp_score:0.139951 mf_score:0.0479912 relationship: child_of NeXO:9962 ! CC: | BP: modification-dependent protein catabolic process | MF: [Term] id: NeXO:9628 name: CC: proteasome regulatory particle | BP: proteasome regulatory particle assembly | MF: def: "CC_def: A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. | BP_def: The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:21.8612591650086 density:0.919117647058823 bootstrap:0.665118051 cc_score:0.536489 bp_score:0.286801 mf_score:0.0 relationship: child_of NeXO:9901 ! CC: proteasome complex | BP: proteasome assembly | MF: [Term] id: NeXO:9623 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.08925565431365 density:0.0952380952380952 bootstrap:0.175690295 cc_score:0.0 bp_score:0.0120145 mf_score:0.0 relationship: child_of NeXO:9913 ! CC: | BP: | MF: [Term] id: NeXO:9622 name: CC: | BP: positive regulation of spindle pole body separation | MF: def: "CC_def: | BP_def: Any process that increases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.10708452899416 density:0.535714285714286 bootstrap:0.230692554 cc_score:0.0 bp_score:0.204257 mf_score:0.0 relationship: child_of NeXO:9819 ! CC: | BP: regulation of spindle pole body separation | MF:cyclin-dependent protein kinase regulator activity [Term] id: NeXO:9621 name: CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.956711388531128 density:0.1 bootstrap:0.244523392 cc_score:0.0 bp_score:0.123642 mf_score:0.0 relationship: child_of NeXO:9723 ! CC: | BP: | MF: relationship: linked_to NeXO:9816 ! CC: | BP: | MF: [Term] id: NeXO:9620 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69314476103787 density:0.0272232304900181 bootstrap:0.1012542 cc_score:0.0 bp_score:0.0560455 mf_score:0.0 relationship: child_of NeXO:9783 ! CC: | BP: | MF: [Term] id: NeXO:9627 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.5579665312983 density:0.672727272727273 bootstrap:0.584355336 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9763 ! CC: | BP: | MF: [Term] id: NeXO:9626 name: CC: | BP: positive regulation of transcription initiation from RNA polymerase II promoter | MF:TFIID-class binding transcription factor activity def: "CC_def: | BP_def: Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.22994504 cc_score:0.0 bp_score:0.138646 mf_score:0.329986 relationship: child_of NeXO:9825 ! CC: | BP: | MF: [Term] id: NeXO:9625 name: CC: | BP: maintenance of meiotic sister chromatid cohesion | MF: def: "CC_def: | BP_def: The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.685568271854 density:1 bootstrap:0.502754432 cc_score:0.0 bp_score:0.143696 mf_score:0.0 relationship: child_of NeXO:9804 ! CC: | BP: | MF: [Term] id: NeXO:9624 name: CC: | BP: negative regulation of transcription during meiosis | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription during meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.28325506995451 density:0.9 bootstrap:0.536620356 cc_score:0.0 bp_score:0.343016 mf_score:0.063607 relationship: child_of NeXO:9764 ! CC: Rpd3L complex | BP: negative regulation of chromatin silencing at rDNA | MF:deacetylase activity [Term] id: NeXO:7218 name: CC: | BP: positive regulation of mitochondrial DNA replication | MF: def: "CC_def: | BP_def: Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.85428888592387 density:1 bootstrap:0.82051534 cc_score:0.0 bp_score:0.219852 mf_score:0.0 relationship: child_of NeXO:8163 ! CC: | BP: | MF: relationship: linked_to NeXO:7045 ! CC: | BP: | MF: relationship: linked_to NeXO:7746 ! CC: | BP: | MF: [Term] id: NeXO:7210 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.88840027372358 density:0.0659340659340659 bootstrap:0.51924968 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9491 ! CC: | BP: | MF: [Term] id: NeXO:7211 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.222623711094 density:1 bootstrap:0.753255024 cc_score:0.0 bp_score:0.0 mf_score:0.0361935 relationship: child_of NeXO:8515 ! CC: | BP: | MF: relationship: linked_to NeXO:6412 ! CC: | BP: | MF: [Term] id: NeXO:7212 name: CC: | BP: fatty acid catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86749610744322 density:0.090909090909091 bootstrap:0.229249279 cc_score:0.0 bp_score:0.10414 mf_score:0.0 relationship: child_of NeXO:8024 ! CC: | BP: | MF:intramolecular oxidoreductase activity [Term] id: NeXO:7330 name: CC: | BP: high-affinity iron ion transport | MF:ferric-chelate reductase activity def: "CC_def: | BP_def: The directed, high-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. | MF_def:Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.3495661902101 density:1 bootstrap:0.61969117 cc_score:0.0 bp_score:0.156556 mf_score:0.203684 relationship: child_of NeXO:8371 ! CC: | BP: copper ion import | MF:oxidoreductase activity, oxidizing metal ions [Term] id: NeXO:7214 name: CC: | BP: | MF:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:1.79411321557472 density:1 bootstrap:0.533361345 cc_score:0.0 bp_score:0.0 mf_score:0.4524 relationship: child_of NeXO:7823 ! CC: | BP: lysine biosynthetic process via aminoadipic acid | MF:saccharopine dehydrogenase activity relationship: linked_to NeXO:5983 ! CC: | BP: positive regulation of cellular amino acid metabolic process | MF:acetyl-CoA:L-glutamate N-acetyltransferase activity [Term] id: NeXO:7215 name: CC: | BP: nicotinamide riboside biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.22152718842216 density:0.166666666666667 bootstrap:0.351152306 cc_score:0.0 bp_score:0.19507 mf_score:0.0 relationship: child_of NeXO:7929 ! CC: | BP: | MF:TBP-class protein binding [Term] id: NeXO:7216 name: CC: extrinsic to intraperoxisomal membrane | BP: peroxisome inheritance | MF: def: "CC_def: Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region. | BP_def: The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22402265208421 density:1 bootstrap:0.81959681 cc_score:0.293957 bp_score:0.439025 mf_score:0.0 relationship: child_of NeXO:8433 ! CC: | BP: | MF: relationship: linked_to NeXO:7324 ! CC: | BP: protein import into peroxisome membrane | MF:peroxisome targeting sequence binding relationship: linked_to NeXO:7998 ! CC: | BP: | MF: [Term] id: NeXO:7217 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.99603376569023 density:0.333333333333333 bootstrap:0.81539483 cc_score:0.0 bp_score:0.0 mf_score:0.0851751 relationship: child_of NeXO:7695 ! CC: | BP: GPI anchor biosynthetic process | MF: [Term] id: NeXO:6217 name: CC: | BP: cysteine biosynthetic process via cystathionine | MF:cystathionine gamma-lyase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. | MF_def:Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.690986531 cc_score:0.0 bp_score:0.194695 mf_score:0.256591 relationship: child_of NeXO:6524 ! CC: | BP: transsulfuration | MF:L-cysteine desulfhydrase activity [Term] id: NeXO:6216 name: CC: | BP: 'de novo' L-methionine biosynthetic process | MF:'de novo' L-methionine biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components. | MF_def:The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.836796248 cc_score:0.0 bp_score:0.44412 mf_score:0.29242 relationship: child_of NeXO:6461 ! CC: | BP: ion transmembrane transporter activity | MF:cystathionine beta-lyase activity relationship: linked_to NeXO:6217 ! CC: | BP: cysteine biosynthetic process via cystathionine | MF:cystathionine gamma-lyase activity [Term] id: NeXO:6214 name: CC: | BP: | MF:anion transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:3.14428516334092 density:0.111111111111111 bootstrap:0.60880067 cc_score:0.0 bp_score:0.0 mf_score:0.114155 relationship: child_of NeXO:6547 ! CC: | BP: | MF: [Term] id: NeXO:6213 name: CC: peroxisomal matrix | BP: | MF:acyl-CoA dehydrogenase activity def: "CC_def: The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. | BP_def: | MF_def:Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.44797195 cc_score:0.130183 bp_score:0.0 mf_score:0.20043 relationship: child_of NeXO:6982 ! CC: | BP: branched chain family amino acid catabolic process | MF: [Term] id: NeXO:6212 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.09622764503479 density:0.194444444444444 bootstrap:0.363555965 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6671 ! CC: | BP: | MF: [Term] id: NeXO:6211 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.850959086 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6985 ! CC: | BP: | MF: relationship: linked_to NeXO:6209 ! CC: mitochondrial proton-transporting ATP synthase, catalytic core | BP: protein complex oligomerization | MF: [Term] id: NeXO:6219 name: CC: | BP: box C/D snoRNA 3'-end processing | MF:metalloexopeptidase activity def: "CC_def: | BP_def: Any process involved in forming the mature 3' end of a box C/D snoRNA molecule. | MF_def:Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [NeXO-GO:term] namespace: NeXO comment: robustness:1.08864364673478 density:0.1 bootstrap:0.316613923 cc_score:0.0 bp_score:0.139942 mf_score:0.158642 relationship: child_of NeXO:6853 ! CC: | BP: | MF: [Term] id: NeXO:6218 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.620932998 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6725 ! CC: | BP: | MF: [Term] id: NeXO:6819 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.579280462 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7097 ! CC: | BP: | MF: relationship: linked_to NeXO:8621 ! CC: | BP: | MF: [Term] id: NeXO:6818 name: CC: | BP: interspecies interaction between organisms | MF:positive regulation of translation def: "CC_def: | BP_def: Any process in which an organism has an effect on an organism of a different species. | MF_def:Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:1.89039525474284 density:1 bootstrap:0.59214366 cc_score:0.0 bp_score:0.292198 mf_score:0.175 relationship: child_of NeXO:7885 ! CC: | BP: DNA transport | MF:DNA transport [Term] id: NeXO:6811 name: CC: | BP: GO:0001180 | MF:RNA polymerase I core binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82173355 cc_score:0.0 bp_score:0.442602 mf_score:0.439385 relationship: child_of NeXO:7442 ! CC: | BP: DNA ligation involved in DNA repair | MF:DNA ligase (ATP) activity [Term] id: NeXO:6810 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.767833433 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7343 ! CC: nascent polypeptide-associated complex | BP: 'de novo' cotranslational protein folding | MF: [Term] id: NeXO:6813 name: CC: | BP: inactivation of MAPK activity involved in osmosensory signaling pathway | MF: def: "CC_def: | BP_def: Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.1003611547337 density:1 bootstrap:0.73098725 cc_score:0.0 bp_score:0.357847 mf_score:0.0 relationship: child_of NeXO:6980 ! CC: | BP: inactivation of MAPK activity | MF: [Term] id: NeXO:6812 name: CC: RNA polymerase I transcription factor complex | BP: transcription of nuclear rRNA large RNA polymerase I transcript | MF:sequence-specific DNA binding RNA polymerase I transcription factor activity def: "CC_def: A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I. | BP_def: | MF_def:Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [NeXO-GO:term] namespace: NeXO comment: robustness:5.94814779920412 density:0.428571428571429 bootstrap:0.84741417 cc_score:0.674374 bp_score:0.309867 mf_score:0.776445 relationship: child_of NeXO:7881 ! CC: | BP: rRNA transcription | MF:RNA polymerase I regulatory region DNA binding [Term] id: NeXO:6815 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85756745 cc_score:0.0 bp_score:0.0122152 mf_score:0.0 relationship: child_of NeXO:9209 ! CC: Set1C/COMPASS complex | BP: histone H3-K4 methylation | MF:histone methyltransferase activity (H3-K4 specific) relationship: linked_to NeXO:8236 ! CC: | BP: histone ubiquitination | MF: [Term] id: NeXO:6814 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8714314 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7814 ! CC: | BP: | MF: [Term] id: NeXO:6817 name: CC: kinesin complex | BP: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay | MF: def: "CC_def: Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. | BP_def: A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71088441 cc_score:0.127494 bp_score:0.438174 mf_score:0.0 relationship: child_of NeXO:7295 ! CC: | BP: nuclear-transcribed mRNA catabolic process, no-go decay | MF: [Term] id: NeXO:9757 name: CC: | BP: actin cortical patch localization | MF: def: "CC_def: | BP_def: Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.98529540819996 density:0.666666666666667 bootstrap:0.34117828 cc_score:0.0 bp_score:0.225478 mf_score:0.0 relationship: child_of NeXO:9905 ! CC: actin cortical patch | BP: actin cytoskeleton organization | MF:actin binding relationship: linked_to NeXO:9023 ! CC: | BP: | MF: relationship: linked_to NeXO:9758 ! CC: | BP: cortical actin cytoskeleton organization | MF: [Term] id: NeXO:9756 name: CC: | BP: histone dephosphorylation | MF: def: "CC_def: | BP_def: The modification of histones by removal of phosphate groups. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.33012009 cc_score:0.0 bp_score:0.313199 mf_score:0.0 relationship: child_of NeXO:9914 ! CC: | BP: regulation of tRNA export from nucleus | MF: relationship: linked_to NeXO:8956 ! CC: | BP: termination of RNA polymerase II transcription, exosome-dependent | MF: relationship: linked_to NeXO:8389 ! CC: | BP: | MF: relationship: linked_to NeXO:6076 ! CC: | BP: | MF: relationship: linked_to NeXO:6325 ! CC: mitochondrial ribonuclease P complex | BP: | MF: relationship: linked_to NeXO:6072 ! CC: | BP: | MF:ornithine metabolic process relationship: linked_to NeXO:5487 ! CC: | BP: regulation of macroautophagy | MF: relationship: linked_to NeXO:6619 ! CC: | BP: | MF: relationship: linked_to NeXO:7011 ! CC: | BP: | MF: [Term] id: NeXO:9755 name: CC: mRNA cleavage factor complex | BP: mRNA polyadenylation | MF: def: "CC_def: Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. | BP_def: The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:20.2598076325052 density:0.738562091503268 bootstrap:0.687571251 cc_score:0.621175 bp_score:0.488795 mf_score:0.0 relationship: child_of NeXO:9915 ! CC: DNA-directed RNA polymerase complex | BP: polyadenylation-dependent mRNA catabolic process | MF:nucleotidyltransferase activity [Term] id: NeXO:9754 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.7339261872259 density:0.818181818181818 bootstrap:0.388273985 cc_score:0.0 bp_score:0.061517 mf_score:0.0 relationship: child_of NeXO:9811 ! CC: | BP: | MF: [Term] id: NeXO:9753 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.69193553684407 density:0.761904761904762 bootstrap:0.254045754 cc_score:0.0 bp_score:0.0602387 mf_score:0.0524974 relationship: child_of NeXO:9858 ! CC: | BP: | MF: [Term] id: NeXO:9752 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.6775355098102 density:0.27 bootstrap:0.506293791 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9949 ! CC: | BP: | MF: [Term] id: NeXO:9751 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.05290643342264 density:0.484848484848485 bootstrap:0.24454057 cc_score:0.0 bp_score:0.0521075 mf_score:0.0 relationship: child_of NeXO:9848 ! CC: H4/H2A histone acetyltransferase complex | BP: | MF: [Term] id: NeXO:9750 name: CC: | BP: negative regulation of meiosis | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.2946936052359 density:0.384615384615385 bootstrap:0.404391725 cc_score:0.0 bp_score:0.202844 mf_score:0.0 relationship: child_of NeXO:9881 ! CC: Rpd3L-Expanded complex | BP: negative regulation of chromatin silencing at telomere | MF:histone deacetylation [Term] id: NeXO:9759 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.4566746662515 density:0.192307692307692 bootstrap:0.57650984 cc_score:0.0558236 bp_score:0.0933894 mf_score:0.0799485 relationship: child_of NeXO:9933 ! CC: | BP: | MF: [Term] id: NeXO:9758 name: CC: | BP: cortical actin cytoskeleton organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.30155465572529 density:0.0865800865800866 bootstrap:0.333265008 cc_score:0.0501881 bp_score:0.15586 mf_score:0.0271367 relationship: child_of NeXO:9905 ! CC: actin cortical patch | BP: actin cytoskeleton organization | MF:actin binding [Term] id: NeXO:7324 name: CC: | BP: protein import into peroxisome membrane | MF:peroxisome targeting sequence binding def: "CC_def: | BP_def: The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. | MF_def:Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [NeXO-GO:term] namespace: NeXO comment: robustness:4.04402647031766 density:1 bootstrap:0.451640151 cc_score:0.0 bp_score:0.440767 mf_score:0.253839 relationship: child_of NeXO:8125 ! CC: | BP: ER-dependent peroxisome organization | MF: relationship: linked_to NeXO:8614 ! CC: | BP: protein import into peroxisome matrix, docking | MF:peroxisome matrix targeting signal-1 binding [Term] id: NeXO:7325 name: CC: | BP: positive regulation of protein binding | MF:peroxisome matrix targeting signal-2 binding def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of protein binding. | MF_def:Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.94938815235079 density:1 bootstrap:0.86150503 cc_score:0.0 bp_score:0.29421 mf_score:0.295627 relationship: child_of NeXO:8306 ! CC: | BP: | MF: relationship: linked_to NeXO:7998 ! CC: | BP: | MF: [Term] id: NeXO:7326 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.73638418576933 density:0.166666666666667 bootstrap:0.70954655 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8338 ! CC: | BP: | MF: [Term] id: NeXO:7327 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.17681743576425 density:0.666666666666667 bootstrap:0.81385415 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8014 ! CC: | BP: | MF: [Term] id: NeXO:7320 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.85639281337281 density:0.4 bootstrap:0.79085624 cc_score:0.0 bp_score:0.040767 mf_score:0.0 relationship: child_of NeXO:7815 ! CC: | BP: | MF: [Term] id: NeXO:7321 name: CC: cytoplasmic dynein complex | BP: microtubule motor activity | MF:microtubule motor activity def: "CC_def: Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains. | BP_def: Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). | MF_def:Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.10623065939893 density:1 bootstrap:0.720054589 cc_score:0.305632 bp_score:0.238636 mf_score:0.245035 relationship: child_of NeXO:8463 ! CC: astral microtubule | BP: | MF: relationship: linked_to NeXO:8883 ! CC: microtubule plus end | BP: nuclear migration along microtubule | MF:microtubule plus-end binding [Term] id: NeXO:7322 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.25756069264108 density:0.102564102564103 bootstrap:0.432214372 cc_score:0.0 bp_score:0.0927499 mf_score:0.0649081 relationship: child_of NeXO:7956 ! CC: | BP: | MF: [Term] id: NeXO:7323 name: CC: | BP: high-affinity zinc ion transport | MF:high affinity zinc uptake transmembrane transporter activity def: "CC_def: | BP_def: The directed, high-affinity movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.266030764 cc_score:0.0 bp_score:0.448575 mf_score:0.442334 relationship: child_of NeXO:7940 ! CC: | BP: | MF: relationship: linked_to NeXO:7324 ! CC: | BP: protein import into peroxisome membrane | MF:peroxisome targeting sequence binding [Term] id: NeXO:5195 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.841792011 cc_score:0.0 bp_score:0.025442 mf_score:0.0 relationship: child_of NeXO:5397 ! CC: | BP: | MF: [Term] id: NeXO:5194 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7939803 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5197 ! CC: | BP: | MF: [Term] id: NeXO:5197 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85015976 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7162 ! CC: | BP: | MF: [Term] id: NeXO:5196 name: CC: | BP: disaccharide catabolic process | MF:oligo-1,6-glucosidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. | MF_def:Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [NeXO-GO:term] namespace: NeXO comment: robustness:4.20992398015595 density:1 bootstrap:0.97891884 cc_score:0.0470609 bp_score:0.107083 mf_score:0.525455 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:7328 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76479071121304 density:0.0294117647058824 bootstrap:0.391080641 cc_score:0.0 bp_score:0.0188223 mf_score:0.0562355 relationship: child_of NeXO:9032 ! CC: | BP: | MF: [Term] id: NeXO:7329 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.47804713431324 density:0.194444444444444 bootstrap:0.458750376 cc_score:0.0 bp_score:0.076994 mf_score:0.0848089 relationship: child_of NeXO:7978 ! CC: | BP: glutamine family amino acid catabolic process | MF: [Term] id: NeXO:5192 name: CC: | BP: tRNA 3'-trailer cleavage, exonucleolytic | MF: def: "CC_def: | BP_def: Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91081451 cc_score:0.0 bp_score:0.45215 mf_score:0.0485106 relationship: child_of NeXO:5807 ! CC: | BP: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III | MF:[pyruvate dehydrogenase (lipoamide)] phosphatase activity [Term] id: NeXO:8848 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.0149106396277 density:0.944444444444444 bootstrap:0.72626359 cc_score:0.0 bp_score:0.0136839 mf_score:0.0 relationship: child_of NeXO:9281 ! CC: mitochondrial respiratory chain | BP: mitochondrial ATP synthesis coupled electron transport | MF:ubiquinol-cytochrome-c reductase activity [Term] id: NeXO:8849 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.14247443650826 density:0.666666666666667 bootstrap:0.41831577 cc_score:0.0 bp_score:0.0744408 mf_score:0.0 relationship: child_of NeXO:9413 ! CC: | BP: gluconeogenesis | MF:fructose-bisphosphate aldolase activity relationship: linked_to NeXO:8234 ! CC: | BP: reactive oxygen species metabolic process | MF:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity relationship: linked_to NeXO:8964 ! CC: | BP: | MF:translation elongation factor activity [Term] id: NeXO:6460 name: CC: TORC2 complex | BP: | MF: def: "CC_def: A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization. In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p; in mammals the complex contains orthologs of the yeast proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35624330091177 density:0.4 bootstrap:0.59902078 cc_score:0.439602 bp_score:0.0149357 mf_score:0.0 relationship: child_of NeXO:7768 ! CC: | BP: establishment or maintenance of actin cytoskeleton polarity | MF:phosphatidylinositol-4,5-bisphosphate binding [Term] id: NeXO:8841 name: CC: | BP: autophagic vacuole fusion | MF: def: "CC_def: | BP_def: The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.30546163213589 density:1 bootstrap:0.77733983 cc_score:0.0 bp_score:0.177876 mf_score:0.0 relationship: child_of NeXO:9297 ! CC: CORVET complex | BP: regulation of vesicle fusion | MF: relationship: linked_to NeXO:8847 ! CC: AP-type membrane coat adaptor complex | BP: | MF: [Term] id: NeXO:8843 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.54899093551748 density:0.110526315789474 bootstrap:0.326041466 cc_score:0.0 bp_score:0.0 mf_score:0.0390968 relationship: child_of NeXO:9513 ! CC: | BP: | MF: [Term] id: NeXO:8844 name: CC: | BP: glycine hydroxymethyltransferase activity | MF:glycine hydroxymethyltransferase activity def: "CC_def: | BP_def: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. | MF_def:Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.50366225744774 density:0.333333333333333 bootstrap:0.457804084 cc_score:0.0 bp_score:0.229402 mf_score:0.232807 relationship: child_of NeXO:9555 ! CC: | BP: | MF: relationship: linked_to NeXO:6229 ! CC: | BP: | MF:arginine transport [Term] id: NeXO:8847 name: CC: AP-type membrane coat adaptor complex | BP: | MF: def: "CC_def: Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.46656124417586 density:0.466666666666667 bootstrap:0.35879227 cc_score:0.195083 bp_score:0.0107425 mf_score:0.0 relationship: child_of NeXO:9837 ! CC: cis-Golgi network | BP: Golgi to vacuole transport | MF:Ras guanyl-nucleotide exchange factor activity [Term] id: NeXO:7669 name: CC: | BP: negative regulation of protein kinase activity | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35738411900535 density:1 bootstrap:0.92083656 cc_score:0.0 bp_score:0.177926 mf_score:0.0 relationship: child_of NeXO:8642 ! CC: eisosome | BP: | MF: relationship: linked_to NeXO:5796 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:6386 ! CC: | BP: | MF: [Term] id: NeXO:7668 name: CC: | BP: global genome nucleotide-excision repair | MF:histone methyltransferase activity (H3-K79 specific) def: "CC_def: | BP_def: The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.93248368607039 density:1 bootstrap:0.61880458 cc_score:0.0 bp_score:0.126669 mf_score:0.44099 relationship: child_of NeXO:8167 ! CC: | BP: | MF:nucleosomal histone binding [Term] id: NeXO:7661 name: CC: | BP: positive regulation of ATPase activity | MF: def: "CC_def: | BP_def: Any process that activates or increases the rate of ATP hydrolysis by an ATPase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.44331757 cc_score:0.0 bp_score:0.177556 mf_score:0.0755837 relationship: child_of NeXO:8257 ! CC: | BP: | MF:Hsp90 protein binding [Term] id: NeXO:7660 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79094473170688 density:0.2 bootstrap:0.267148131 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8404 ! CC: | BP: | MF: [Term] id: NeXO:7662 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.513343637 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8588 ! CC: | BP: | MF: [Term] id: NeXO:7665 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77245501 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8375 ! CC: | BP: arsenite transport | MF:arsenite transport [Term] id: NeXO:7664 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.50146667661824 density:0.0769230769230769 bootstrap:0.319134265 cc_score:0.0 bp_score:0.0511905 mf_score:0.0 relationship: child_of NeXO:8722 ! CC: | BP: | MF: [Term] id: NeXO:7667 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.699391 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8531 ! CC: | BP: DNA geometric change | MF: relationship: linked_to NeXO:7839 ! CC: | BP: DNA duplex unwinding | MF:single-stranded DNA-dependent ATPase activity [Term] id: NeXO:7666 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.84466935098984 density:0.4 bootstrap:0.292020669 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8006 ! CC: | BP: | MF: [Term] id: NeXO:5890 name: CC: | BP: acetate biosynthetic process | MF:aldehyde dehydrogenase (NADP+) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. | MF_def:Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.04522569287903 density:1 bootstrap:0.69311345 cc_score:0.0 bp_score:0.448151 mf_score:0.450552 relationship: child_of NeXO:6740 ! CC: | BP: acetate metabolic process | MF:aldehyde dehydrogenase (NAD) activity relationship: linked_to NeXO:5215 ! CC: | BP: polyamine catabolic process | MF:aldehyde dehydrogenase [NAD(P)+] activity [Term] id: NeXO:5449 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89531435 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5450 ! CC: | BP: | MF:aryl-alcohol dehydrogenase activity [Term] id: NeXO:5448 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.17348938849218 density:0.666666666666667 bootstrap:0.91779786 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5451 ! CC: | BP: | MF: [Term] id: NeXO:7069 name: CC: | BP: potassium ion transport | MF:metal ion transport def: "CC_def: | BP_def: The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:4.43032155092601 density:0.108333333333333 bootstrap:0.49459869 cc_score:0.0 bp_score:0.16275 mf_score:0.123885 relationship: child_of NeXO:8533 ! CC: | BP: | MF: [Term] id: NeXO:7068 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.586272441 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8943 ! CC: integral to Golgi membrane | BP: | MF: [Term] id: NeXO:7067 name: CC: chromosome passenger complex | BP: mitotic spindle disassembly | MF: def: "CC_def: A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin. | BP_def: The controlled breakdown of the spindle during a mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06791440609284 density:1 bootstrap:0.708576858 cc_score:0.44278 bp_score:0.293332 mf_score:0.0591518 relationship: child_of NeXO:9147 ! CC: spindle midzone | BP: mitotic spindle stabilization | MF: relationship: linked_to NeXO:7447 ! CC: | BP: | MF: [Term] id: NeXO:5442 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.1619527917584 density:1 bootstrap:0.9567368 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6829 ! CC: | BP: | MF: [Term] id: NeXO:7065 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.91119273658745 density:1 bootstrap:0.57897689 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7728 ! CC: | BP: re-entry into mitotic cell cycle after pheromone arrest | MF: [Term] id: NeXO:7063 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.25000070782931 density:0.666666666666667 bootstrap:0.492745319 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8980 ! CC: | BP: | MF: [Term] id: NeXO:5446 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61072898 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5709 ! CC: | BP: | MF: [Term] id: NeXO:5445 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83275249 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6045 ! CC: | BP: | MF: [Term] id: NeXO:5444 name: CC: | BP: positive regulation of lipid transport | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.11750076007842 density:0.666666666666667 bootstrap:0.88569884 cc_score:0.0 bp_score:0.115477 mf_score:0.0 relationship: child_of NeXO:5746 ! CC: | BP: | MF: [Term] id: NeXO:8570 name: CC: AP-3 adaptor complex | BP: | MF: def: "CC_def: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.13548560262025 density:1 bootstrap:0.72832899 cc_score:0.888511 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8847 ! CC: AP-type membrane coat adaptor complex | BP: | MF: [Term] id: NeXO:8571 name: CC: RAVE complex | BP: early endosome to late endosome transport | MF: def: "CC_def: A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. | BP_def: The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.2967452040378 density:1 bootstrap:0.77478772 cc_score:0.350162 bp_score:0.220093 mf_score:0.0 relationship: child_of NeXO:9691 ! CC: | BP: | MF: relationship: linked_to NeXO:8847 ! CC: AP-type membrane coat adaptor complex | BP: | MF: [Term] id: NeXO:6961 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81318678383698 density:0.666666666666667 bootstrap:0.29961119 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7263 ! CC: | BP: vacuolar proton-transporting V-type ATPase complex assembly | MF: [Term] id: NeXO:6960 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.546700391 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7670 ! CC: | BP: | MF: [Term] id: NeXO:6963 name: CC: | BP: regulation of phosphatidylinositol biosynthetic process | MF:1-phosphatidylinositol-3-phosphate 5-kinase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. | MF_def:Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.96713057309904 density:1 bootstrap:0.86926295 cc_score:0.0 bp_score:0.134874 mf_score:0.30241 relationship: child_of NeXO:7475 ! CC: external side of endosome membrane | BP: | MF:phosphatidylinositol phosphate kinase activity [Term] id: NeXO:6962 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.64780304194519 density:0.6 bootstrap:0.699737506 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6999 ! CC: mitochondrial respiratory chain complex II | BP: mitochondrial electron transport, succinate to ubiquinone | MF:succinate dehydrogenase (ubiquinone) activity [Term] id: NeXO:8628 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.55655074072563 density:1 bootstrap:0.80874416 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9666 ! CC: | BP: | MF: relationship: linked_to NeXO:9298 ! CC: | BP: | MF:phosphatidylinositol phosphate 5-phosphatase activity [Term] id: NeXO:6964 name: CC: ribonucleoside-diphosphate reductase complex | BP: deoxyribonucleoside diphosphate metabolic process | MF:ribonucleoside-diphosphate reductase activity def: "CC_def: An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. | BP_def: The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar. | MF_def:Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [NeXO-GO:term] namespace: NeXO comment: robustness:3.84510592046155 density:1 bootstrap:0.81661019 cc_score:0.656357 bp_score:0.432566 mf_score:0.675822 relationship: child_of NeXO:7710 ! CC: | BP: deoxyribonucleotide biosynthetic process | MF:oxidoreductase activity, acting on CH or CH2 groups relationship: linked_to NeXO:6377 ! CC: | BP: regulation of transcription during meiosis | MF: [Term] id: NeXO:6967 name: CC: | BP: | MF:dolichol kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.293291339 cc_score:0.0 bp_score:0.0732764 mf_score:0.205812 relationship: child_of NeXO:7545 ! CC: | BP: | MF: [Term] id: NeXO:8159 name: CC: TRC complex | BP: posttranslational protein targeting to membrane | MF: def: "CC_def: An ER membrane insertion complex that contains subunits that recognize two types of transmembrane domain signals. In budding yeast the complex contains Get4p, Get5p, Sgt2p, and at least two heat shock proteins (HSPs). | BP_def: The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.60035536390913 density:1 bootstrap:0.71596026 cc_score:0.375573 bp_score:0.238233 mf_score:0.0 relationship: child_of NeXO:8807 ! CC: | BP: | MF: [Term] id: NeXO:6969 name: CC: | BP: sulfate transport | MF:secondary active sulfate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [NeXO-GO:term] namespace: NeXO comment: robustness:4.1983956900276 density:0.5 bootstrap:0.714899584 cc_score:0.0 bp_score:0.245466 mf_score:0.244698 relationship: child_of NeXO:7718 ! CC: | BP: telomere localization | MF: [Term] id: NeXO:8157 name: CC: | BP: | MF:cytidylyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a cytidylyl group to an acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:3.79560638057003 density:0.833333333333333 bootstrap:0.507532376 cc_score:0.0 bp_score:0.0 mf_score:0.137815 relationship: child_of NeXO:8899 ! CC: | BP: | MF:CDP-choline pathway [Term] id: NeXO:8626 name: CC: GSE complex | BP: | MF: def: "CC_def: A conserved protein complex required for protein sorting from endosome to the plasma membrane. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Slm4p, Meh1p and Ltv1p and it sorts Gap1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.18552042575864 density:1 bootstrap:0.85551464 cc_score:0.220074 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9666 ! CC: | BP: | MF: relationship: linked_to NeXO:8625 ! CC: extrinsic to vacuolar membrane | BP: | MF: relationship: linked_to NeXO:8628 ! CC: | BP: | MF: [Term] id: NeXO:8627 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89528315310576 density:1 bootstrap:0.59520977 cc_score:0.0 bp_score:0.0105051 mf_score:0.0 relationship: child_of NeXO:9563 ! CC: Seh1-associated complex | BP: | MF: relationship: linked_to NeXO:8783 ! CC: | BP: snRNP protein import into nucleus | MF: relationship: linked_to NeXO:8298 ! CC: COPII vesicle coat | BP: regulation of COPII vesicle coating | MF: relationship: linked_to NeXO:7102 ! CC: extrinsic to fungal-type vacuolar membrane | BP: cellular response to amino acid starvation | MF: relationship: linked_to NeXO:8356 ! CC: TORC1 complex | BP: | MF: [Term] id: NeXO:8620 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75791392752763 density:1 bootstrap:0.51205553 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9224 ! CC: | BP: | MF: relationship: linked_to NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9225 ! CC: | BP: | MF: [Term] id: NeXO:8621 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.64456370481081 density:1 bootstrap:0.73365059 cc_score:0.0 bp_score:0.0586221 mf_score:0.0 relationship: child_of NeXO:9269 ! CC: | BP: | MF: relationship: linked_to NeXO:7917 ! CC: | BP: D-serine metabolic process | MF:D-serine ammonia-lyase activity relationship: linked_to NeXO:7002 ! CC: | BP: | MF: relationship: linked_to NeXO:8167 ! CC: | BP: | MF:nucleosomal histone binding [Term] id: NeXO:8150 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.407872685 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8953 ! CC: | BP: | MF: [Term] id: NeXO:8623 name: CC: | BP: Rho guanyl-nucleotide exchange factor activity | MF:lanosterol O-acyltransferase activity def: "CC_def: | BP_def: Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. | MF_def:Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [NeXO-GO:term] namespace: NeXO comment: robustness:1.18092550125462 density:1 bootstrap:0.231082389 cc_score:0.0 bp_score:0.125 mf_score:0.4375 relationship: child_of NeXO:9346 ! CC: | BP: | MF: relationship: linked_to NeXO:6175 ! CC: | BP: triglyceride metabolic process | MF:ergosterol O-acyltransferase activity relationship: linked_to NeXO:6428 ! CC: | BP: N-terminal peptidyl-proline dimethylation | MF:N-terminal protein N-methyltransferase activity relationship: linked_to NeXO:7620 ! CC: | BP: | MF: [Term] id: NeXO:5898 name: CC: Golgi medial cisterna | BP: | MF: def: "CC_def: The middle Golgi cisterna (or cisternae). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.38006704336852 density:1 bootstrap:0.93864253 cc_score:0.222145 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7645 ! CC: | BP: | MF: [Term] id: NeXO:5508 name: CC: | BP: citrate metabolic process | MF:isocitrate hydro-lyase (cis-aconitate-forming) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle. | MF_def:Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49274453 cc_score:0.0 bp_score:0.218963 mf_score:0.293313 relationship: child_of NeXO:5820 ! CC: | BP: | MF:citrate hydro-lyase (cis-aconitate-forming) activity [Term] id: NeXO:5509 name: CC: | BP: | MF:glutamate dehydrogenase (NADP+) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84157159 cc_score:0.0 bp_score:0.0 mf_score:0.298525 relationship: child_of NeXO:6695 ! CC: | BP: | MF: [Term] id: NeXO:5506 name: CC: | BP: inosine salvage | MF:IMP 5'-nucleotidase activity def: "CC_def: | BP_def: Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis. | MF_def:Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.81289255572108 density:1 bootstrap:0.54458538 cc_score:0.0 bp_score:0.444252 mf_score:0.448596 relationship: child_of NeXO:5722 ! CC: | BP: inosine metabolic process | MF:nucleotidase activity [Term] id: NeXO:5504 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84096708 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6738 ! CC: | BP: | MF: [Term] id: NeXO:5505 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89509519 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6609 ! CC: | BP: | MF: [Term] id: NeXO:5502 name: CC: | BP: | MF:nitrite reductase (NO-forming) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8468867 cc_score:0.0 bp_score:0.0 mf_score:0.445302 relationship: child_of NeXO:6179 ! CC: | BP: | MF:oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: NeXO:5503 name: CC: | BP: dehydro-D-arabinono-1,4-lactone biosynthetic process | MF:NAD+ synthase (glutamine-hydrolyzing) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one. | MF_def:Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.44031172 cc_score:0.0 bp_score:0.292105 mf_score:0.440308 relationship: child_of NeXO:5745 ! CC: | BP: | MF:D-arabinono-1,4-lactone oxidase activity [Term] id: NeXO:5501 name: CC: | BP: tyrosine catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83997821 cc_score:0.0 bp_score:0.295462 mf_score:0.0 relationship: child_of NeXO:6958 ! CC: | BP: | MF: [Term] id: NeXO:8711 name: CC: | BP: pyrimidine nucleoside triphosphate biosynthetic process | MF:glutamine-fructose-6-phosphate transaminase (isomerizing) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. | MF_def:Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62049798 cc_score:0.0 bp_score:0.160928 mf_score:0.293597 relationship: child_of NeXO:9612 ! CC: | BP: GDP-mannose biosynthetic process | MF:mannose-1-phosphate guanylyltransferase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9443 ! CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity [Term] id: NeXO:8712 name: CC: | BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08281189498675 density:1 bootstrap:0.718822968 cc_score:0.0 bp_score:0.182915 mf_score:0.0 relationship: child_of NeXO:9362 ! CC: | BP: | MF: relationship: linked_to NeXO:8910 ! CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity [Term] id: NeXO:8713 name: CC: | BP: cholesterol biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.49598761921775 density:0.266666666666667 bootstrap:0.36771354 cc_score:0.0 bp_score:0.194562 mf_score:0.0 relationship: child_of NeXO:9447 ! CC: | BP: | MF: [Term] id: NeXO:8714 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.56824832324132 density:0.357142857142857 bootstrap:0.47428294 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9490 ! CC: | BP: | MF: [Term] id: NeXO:8715 name: CC: | BP: sterol deacetylation | MF:steryl deacetylase activity def: "CC_def: | BP_def: The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. | MF_def:Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52079661 cc_score:0.0 bp_score:0.438691 mf_score:0.440328 relationship: child_of NeXO:9268 ! CC: | BP: | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:7724 ! CC: anthranilate synthase complex | BP: tryptophan biosynthetic process | MF:tryptophan biosynthetic process [Term] id: NeXO:8716 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.405384739 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9969 ! CC: | BP: | MF: relationship: linked_to NeXO:9257 ! CC: | BP: | MF: [Term] id: NeXO:8717 name: CC: | BP: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.70098225821005 density:1 bootstrap:0.74402568 cc_score:0.0 bp_score:0.15979 mf_score:0.0822326 relationship: child_of NeXO:8986 ! CC: | BP: transcriptional start site selection at RNA polymerase II promoter | MF: [Term] id: NeXO:7193 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90380309416203 density:0.333333333333333 bootstrap:0.386882381 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7925 ! CC: N-terminal protein acetyltransferase complex | BP: N-terminal protein amino acid acetylation | MF:peptide alpha-N-acetyltransferase activity [Term] id: NeXO:8719 name: CC: fatty acid synthase complex | BP: | MF:fatty-acyl-CoA synthase activity def: "CC_def: A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.6481851337411 density:1 bootstrap:0.450125723 cc_score:0.291934 bp_score:0.0130189 mf_score:0.297587 relationship: child_of NeXO:9057 ! CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity relationship: linked_to NeXO:6537 ! CC: | BP: lipoate biosynthetic process | MF:S-adenosylmethionine transmembrane transporter activity relationship: linked_to NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding [Term] id: NeXO:7191 name: CC: | BP: siderophore transport | MF:siderophore transport def: "CC_def: | BP_def: The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:5.06471320853376 density:0.7 bootstrap:0.6846818 cc_score:0.0 bp_score:0.319359 mf_score:0.30774 relationship: child_of NeXO:7899 ! CC: | BP: | MF: [Term] id: NeXO:7197 name: CC: | BP: anaerobic respiration | MF:ATP:ADP antiporter activity def: "CC_def: | BP_def: The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. | MF_def:Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33411537858482 density:1 bootstrap:0.9027479 cc_score:0.0 bp_score:0.292707 mf_score:0.178572 relationship: child_of NeXO:8868 ! CC: | BP: ATP transport | MF:ATP transport [Term] id: NeXO:7196 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.08354532208913 density:1 bootstrap:0.71367086 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7653 ! CC: | BP: | MF: [Term] id: NeXO:7195 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.50152853581573 density:0.138888888888889 bootstrap:0.704749576 cc_score:0.0 bp_score:0.0178801 mf_score:0.0761511 relationship: child_of NeXO:8973 ! CC: | BP: | MF:drug transmembrane transport [Term] id: NeXO:7194 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.447800737 cc_score:0.0 bp_score:0.0144134 mf_score:0.0 relationship: child_of NeXO:7457 ! CC: | BP: | MF: [Term] id: NeXO:7566 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.79085376469475 density:1 bootstrap:0.555643432 cc_score:0.0 bp_score:0.0814857 mf_score:0.0510094 relationship: child_of NeXO:8118 ! CC: | BP: | MF: [Term] id: NeXO:7567 name: CC: | BP: L-methionine salvage from methylthioadenosine | MF:acireductone dioxygenase [iron(II)-requiring] activity def: "CC_def: | BP_def: The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. | MF_def:Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.214940264 cc_score:0.0 bp_score:0.148752 mf_score:0.44232 relationship: child_of NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:7514 ! CC: | BP: | MF:NADH pyrophosphatase activity relationship: linked_to NeXO:7923 ! CC: | BP: | MF: [Term] id: NeXO:6465 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.88246411403813 density:0.166666666666667 bootstrap:0.69176583 cc_score:0.0 bp_score:0.0258381 mf_score:0.0 relationship: child_of NeXO:7084 ! CC: | BP: | MF: [Term] id: NeXO:7564 name: CC: | BP: glycerol metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.51746530606821 density:0.214285714285714 bootstrap:0.52837129 cc_score:0.0 bp_score:0.221157 mf_score:0.0 relationship: child_of NeXO:8040 ! CC: | BP: polyol metabolic process | MF: [Term] id: NeXO:8538 name: CC: | BP: | MF:G-protein coupled receptor protein signaling pathway def: "CC_def: | BP_def: | MF_def:The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [NeXO-GO:term] namespace: NeXO comment: robustness:1.24196787928251 density:0.0555555555555556 bootstrap:0.271638244 cc_score:0.0 bp_score:0.0205188 mf_score:0.102489 relationship: child_of NeXO:9498 ! CC: | BP: | MF: [Term] id: NeXO:8539 name: CC: | BP: regulation of MAPK export from nucleus | MF:G-protein-coupled receptor binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm. | MF_def:Interacting selectively and non-covalently with a G-protein-coupled receptor." [NeXO-GO:term] namespace: NeXO comment: robustness:1.15777347391082 density:1 bootstrap:0.222110473 cc_score:0.0 bp_score:0.294597 mf_score:0.298552 relationship: child_of NeXO:8731 ! CC: | BP: cortical protein anchoring | MF:SAM domain binding relationship: linked_to NeXO:8954 ! CC: | BP: regulation of transposition, RNA-mediated | MF:positive regulation of signal transduction [Term] id: NeXO:8028 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.823365676 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9414 ! CC: | BP: ribonucleoprotein complex disassembly | MF: [Term] id: NeXO:8029 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.57491972255244 density:0.142857142857143 bootstrap:0.22663168 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9153 ! CC: | BP: | MF: [Term] id: NeXO:9988 name: CC: DNA-directed RNA polymerase II, holoenzyme | BP: RNA polymerase II transcriptional preinitiation complex assembly | MF:RNA polymerase II transcriptional preinitiation complex assembly def: "CC_def: Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. | BP_def: The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. | MF_def:The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [NeXO-GO:term] namespace: NeXO comment: robustness:19.3192289621319 density:0.327340031729244 bootstrap:0.509003366 cc_score:0.289902 bp_score:0.25299 mf_score:0.281424 relationship: child_of NeXO:9989 ! CC: nucleoplasm part | BP: chromatin modification | MF:transcription, DNA-dependent [Term] id: NeXO:9989 name: CC: nucleoplasm part | BP: chromatin modification | MF:transcription, DNA-dependent def: "CC_def: Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. | BP_def: The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. | MF_def:The cellular synthesis of RNA on a template of DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:18.2498034750572 density:0.0644552815605447 bootstrap:0.454210803 cc_score:0.217336 bp_score:0.332205 mf_score:0.189414 relationship: child_of NeXO:10013 ! CC: chromosome | BP: chromatin organization | MF:DNA binding [Term] id: NeXO:8022 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.446164576 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9160 ! CC: | BP: | MF: [Term] id: NeXO:8023 name: CC: | BP: negative regulation of kinase activity | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19823785225427 density:1 bootstrap:0.800702548 cc_score:0.0 bp_score:0.120501 mf_score:0.0 relationship: child_of NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: [Term] id: NeXO:8020 name: CC: | BP: | MF:carbohydrate phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58906997499006 density:0.0545454545454545 bootstrap:0.314721589 cc_score:0.0 bp_score:0.0891969 mf_score:0.147384 relationship: child_of NeXO:8659 ! CC: | BP: | MF: [Term] id: NeXO:8021 name: CC: phosphopantothenoylcysteine decarboxylase complex | BP: coenzyme A biosynthetic process | MF:phosphopantothenoylcysteine decarboxylase activity def: "CC_def: A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces. | BP_def: The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. | MF_def:Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.92390127657324 density:0.833333333333333 bootstrap:0.54242233 cc_score:0.606719 bp_score:0.308657 mf_score:0.610449 relationship: child_of NeXO:8452 ! CC: | BP: coenzyme A metabolic process | MF:protein phosphatase inhibitor activity [Term] id: NeXO:8534 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.922535717508 density:1 bootstrap:0.612450059 cc_score:0.0 bp_score:0.0112194 mf_score:0.0 relationship: child_of NeXO:9416 ! CC: | BP: ribosomal protein import into nucleus | MF:protein export from nucleus relationship: linked_to NeXO:8376 ! CC: Nup107-160 complex | BP: snRNA export from nucleus | MF: relationship: linked_to NeXO:9091 ! CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: relationship: linked_to NeXO:9092 ! CC: NDC1 complex | BP: mRNA export from nucleus in response to heat stress | MF: relationship: linked_to NeXO:9059 ! CC: | BP: | MF: relationship: linked_to NeXO:8283 ! CC: | BP: | MF:protein-arginine N-methyltransferase activity [Term] id: NeXO:8027 name: CC: gamma-tubulin small complex, spindle pole body | BP: | MF: def: "CC_def: A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51260739224309 density:0.2 bootstrap:0.525819925 cc_score:0.226965 bp_score:0.0825841 mf_score:0.0 relationship: child_of NeXO:9075 ! CC: microtubule organizing center part | BP: | MF: [Term] id: NeXO:8536 name: CC: | BP: distributive segregation | MF: def: "CC_def: | BP_def: The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a "backup" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09029941431463 density:1 bootstrap:0.724000464 cc_score:0.0 bp_score:0.439121 mf_score:0.0 relationship: child_of NeXO:9121 ! CC: mitotic checkpoint complex | BP: | MF: relationship: linked_to NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding [Term] id: NeXO:8537 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32598768118884 density:0.666666666666667 bootstrap:0.493046364 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9342 ! CC: | BP: negative regulation of transcription factor import into nucleus | MF: [Term] id: NeXO:7441 name: CC: | BP: | MF:actin lateral binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with an actin filament along its length." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.43279751 cc_score:0.0 bp_score:0.0 mf_score:0.233817 relationship: child_of NeXO:7700 ! CC: | BP: sequestering of actin monomers | MF:actin monomer binding [Term] id: NeXO:7443 name: CC: | BP: | MF:glutamate-5-semialdehyde dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.454340821 cc_score:0.0 bp_score:0.0260087 mf_score:0.207157 relationship: child_of NeXO:8659 ! CC: | BP: | MF: [Term] id: NeXO:5619 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.83315206886571 density:1 bootstrap:0.556825138 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5713 ! CC: | BP: | MF: [Term] id: NeXO:6569 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.77669267122646 density:0.666666666666667 bootstrap:0.70263304 cc_score:0.0 bp_score:0.0 mf_score:0.0430956 relationship: child_of NeXO:6570 ! CC: | BP: | MF: [Term] id: NeXO:6568 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68260038 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7202 ! CC: | BP: | MF: [Term] id: NeXO:7447 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45847564111577 density:0.166666666666667 bootstrap:0.50059627 cc_score:0.0 bp_score:0.0109488 mf_score:0.0 relationship: child_of NeXO:8317 ! CC: | BP: | MF: [Term] id: NeXO:7446 name: CC: | BP: regulation of 1,6-beta-glucan biosynthetic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,6 glucans. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.373387249 cc_score:0.0 bp_score:0.293007 mf_score:0.0 relationship: child_of NeXO:8403 ! CC: | BP: | MF: [Term] id: NeXO:7449 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82479170898228 density:1 bootstrap:0.80800446 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7979 ! CC: | BP: | MF: relationship: linked_to NeXO:7980 ! CC: | BP: nuclear mRNA 3'-splice site recognition | MF: [Term] id: NeXO:6466 name: CC: | BP: ornithine biosynthetic process | MF:ornithine carbamoyltransferase inhibitor activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. | MF_def:Stops, prevents, or reduces ornithine carbamoyltransferase activity, the catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53523843 cc_score:0.0 bp_score:0.275831 mf_score:0.210682 relationship: child_of NeXO:7822 ! CC: | BP: arginine biosynthetic process | MF:carboxyl- or carbamoyltransferase activity [Term] id: NeXO:6567 name: CC: | BP: allantoate transport | MF:allantoate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.509103193 cc_score:0.0 bp_score:0.315439 mf_score:0.316324 relationship: child_of NeXO:8111 ! CC: | BP: nitrogen catabolite regulation of transcription | MF:gamma-aminobutyric acid:hydrogen symporter activity [Term] id: NeXO:5611 name: CC: | BP: | MF:thioredoxin peroxidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20359978272986 density:1 bootstrap:0.804613451 cc_score:0.0 bp_score:0.0 mf_score:0.112565 relationship: child_of NeXO:5712 ! CC: | BP: | MF: [Term] id: NeXO:6561 name: CC: | BP: hydrogen sulfide biosynthetic process | MF:cystathionine beta-synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. | MF_def:Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.678952839 cc_score:0.0 bp_score:0.250582 mf_score:0.251628 relationship: child_of NeXO:7408 ! CC: | BP: | MF: [Term] id: NeXO:6563 name: CC: | BP: positive regulation of invasive growth in response to glucose limitation | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.05724693280098 density:1 bootstrap:0.90920342 cc_score:0.0 bp_score:0.457866 mf_score:0.0 relationship: child_of NeXO:8594 ! CC: | BP: regulation of invasive growth in response to glucose limitation | MF: [Term] id: NeXO:6562 name: CC: | BP: | MF:chitin binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [NeXO-GO:term] namespace: NeXO comment: robustness:1.62468588252679 density:0.166666666666667 bootstrap:0.621195159 cc_score:0.0 bp_score:0.0839032 mf_score:0.158925 relationship: child_of NeXO:7423 ! CC: | BP: | MF: [Term] id: NeXO:7685 name: CC: | BP: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) | MF: def: "CC_def: | BP_def: Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.814573717 cc_score:0.0 bp_score:0.176703 mf_score:0.0 relationship: child_of NeXO:8482 ! CC: | BP: | MF: [Term] id: NeXO:7683 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.84973567309188 density:0.3 bootstrap:0.256674152 cc_score:0.0 bp_score:0.0710096 mf_score:0.0 relationship: child_of NeXO:8371 ! CC: | BP: copper ion import | MF:oxidoreductase activity, oxidizing metal ions [Term] id: NeXO:7682 name: CC: | BP: beta-glucan biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of beta-glucans. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07683704151587 density:0.102564102564103 bootstrap:0.385587692 cc_score:0.0 bp_score:0.109872 mf_score:0.0 relationship: child_of NeXO:8708 ! CC: | BP: | MF: [Term] id: NeXO:7681 name: CC: | BP: regulation of sporulation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39994838662408 density:0.333333333333333 bootstrap:0.614806852 cc_score:0.0 bp_score:0.222606 mf_score:0.0 relationship: child_of NeXO:8808 ! CC: | BP: | MF: relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity [Term] id: NeXO:8184 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:24.6371719006499 density:0.763157894736842 bootstrap:0.827794969 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9574 ! CC: mitochondrial small ribosomal subunit | BP: | MF: [Term] id: NeXO:6408 name: CC: | BP: glucose import | MF: def: "CC_def: | BP_def: The directed movement of the hexose monosaccharide glucose into a cell or organelle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.751688412 cc_score:0.0 bp_score:0.136342 mf_score:0.0 relationship: child_of NeXO:7507 ! CC: | BP: | MF: [Term] id: NeXO:7689 name: CC: | BP: | MF:sterol transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.44601049366051 density:0.178571428571429 bootstrap:0.319505594 cc_score:0.0 bp_score:0.093109 mf_score:0.197211 relationship: child_of NeXO:8743 ! CC: | BP: GPI anchor metabolic process | MF: [Term] id: NeXO:7688 name: CC: tRNA (m2G10) methyltransferase complex | BP: response to methylglyoxal | MF:tRNA (guanine-N2-)-methyltransferase activity def: "CC_def: A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p. | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.79593170002229 density:1 bootstrap:0.534443106 cc_score:0.295542 bp_score:0.440669 mf_score:0.220895 relationship: child_of NeXO:8378 ! CC: | BP: | MF: relationship: linked_to NeXO:6832 ! CC: | BP: | MF: relationship: linked_to NeXO:8594 ! CC: | BP: regulation of invasive growth in response to glucose limitation | MF: [Term] id: NeXO:5714 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.73043216760992 density:0.333333333333333 bootstrap:0.606300916 cc_score:0.0 bp_score:0.0564005 mf_score:0.0 relationship: child_of NeXO:7697 ! CC: | BP: | MF: [Term] id: NeXO:7115 name: CC: | BP: protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | MF: def: "CC_def: | BP_def: The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.31652626 cc_score:0.0 bp_score:0.110523 mf_score:0.0 relationship: child_of NeXO:7116 ! CC: | BP: | MF: [Term] id: NeXO:6878 name: CC: anchored to plasma membrane | BP: | MF:mannan endo-1,6-alpha-mannosidase activity def: "CC_def: Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane. | BP_def: | MF_def:Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [NeXO-GO:term] namespace: NeXO comment: robustness:2.11034932089829 density:1 bootstrap:0.73795613 cc_score:0.176111 bp_score:0.0670515 mf_score:0.302985 relationship: child_of NeXO:7305 ! CC: | BP: | MF:FAD transmembrane transporter activity relationship: linked_to NeXO:8197 ! CC: | BP: | MF:phosphatidylinositol deacylase activity [Term] id: NeXO:5557 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.74545867186128 density:1 bootstrap:0.504825155 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6378 ! CC: | BP: | MF: relationship: linked_to NeXO:6929 ! CC: | BP: | MF: relationship: linked_to NeXO:7312 ! CC: | BP: | MF: [Term] id: NeXO:8180 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.7520348582539 density:0.638888888888889 bootstrap:0.653106458 cc_score:0.0 bp_score:0.0611005 mf_score:0.0852248 relationship: child_of NeXO:8735 ! CC: | BP: | MF: [Term] id: NeXO:8444 name: CC: | BP: two-component signal transduction system (phosphorelay) | MF:two-component signal transduction system (phosphorelay) def: "CC_def: | BP_def: A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. | MF_def:A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:7.09928926068033 density:0.5 bootstrap:0.75204421 cc_score:0.0 bp_score:0.282316 mf_score:0.210228 relationship: child_of NeXO:9333 ! CC: | BP: osmosensory signaling pathway | MF: [Term] id: NeXO:8445 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.08071966979497 density:0.866666666666667 bootstrap:0.88469812 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9349 ! CC: | BP: | MF: [Term] id: NeXO:8446 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.483725823 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9187 ! CC: | BP: | MF: [Term] id: NeXO:8447 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21138912747874 density:0.0432900432900433 bootstrap:0.225256602 cc_score:0.0 bp_score:0.0313359 mf_score:0.0 relationship: child_of NeXO:9303 ! CC: | BP: | MF: [Term] id: NeXO:8440 name: CC: | BP: negative regulation of cellular carbohydrate metabolic process | MF: def: "CC_def: | BP_def: Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.1305599247624 density:0.323809523809524 bootstrap:0.58815149 cc_score:0.0 bp_score:0.289564 mf_score:0.0868535 relationship: child_of NeXO:8818 ! CC: | BP: regulation of gluconeogenesis | MF: [Term] id: NeXO:8441 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.488634538 cc_score:0.0908829 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8670 ! CC: | BP: negative regulation of histone H3-K36 methylation | MF: [Term] id: NeXO:8442 name: CC: | BP: ammonium transmembrane transport | MF:ammonium transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. | MF_def:Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71139905 cc_score:0.0 bp_score:0.222371 mf_score:0.128106 relationship: child_of NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity [Term] id: NeXO:8443 name: CC: | BP: fermentation | MF: def: "CC_def: | BP_def: The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.51197877706557 density:0.142857142857143 bootstrap:0.160322696 cc_score:0.0 bp_score:0.153073 mf_score:0.0 relationship: child_of NeXO:9167 ! CC: | BP: | MF: [Term] id: NeXO:8182 name: CC: nucleotide-excision repair factor 3 complex | BP: | MF:phosphatidylinositol-5-phosphate binding def: "CC_def: One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p). | BP_def: | MF_def:Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [NeXO-GO:term] namespace: NeXO comment: robustness:2.27606983441076 density:1 bootstrap:0.85840653 cc_score:0.256496 bp_score:0.0 mf_score:0.219523 relationship: child_of NeXO:8913 ! CC: holo TFIIH complex | BP: phosphorylation of RNA polymerase II C-terminal domain | MF: relationship: linked_to NeXO:7103 ! CC: | BP: nucleotide-excision repair, DNA incision, 3'-to lesion | MF: relationship: linked_to NeXO:7781 ! CC: | BP: | MF: [Term] id: NeXO:8448 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.61570077990681 density:1 bootstrap:0.43255737 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9309 ! CC: proteasome core complex, beta-subunit complex | BP: endopeptidase activity | MF: relationship: linked_to NeXO:8061 ! CC: proteasome storage granule | BP: | MF: relationship: linked_to NeXO:7998 ! CC: | BP: | MF: relationship: linked_to NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:9135 ! CC: | BP: | MF: [Term] id: NeXO:8449 name: CC: lipid particle | BP: | MF: def: "CC_def: Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.98879106625385 density:0.0513833992094862 bootstrap:0.298534572 cc_score:0.110039 bp_score:0.0302041 mf_score:0.0372664 relationship: child_of NeXO:9478 ! CC: | BP: | MF: [Term] id: NeXO:6874 name: CC: | BP: regulation of adenylate cyclase activity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of adenylate cyclase activity. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.83363755151836 density:0.666666666666667 bootstrap:0.73174799 cc_score:0.0 bp_score:0.114126 mf_score:0.0 relationship: child_of NeXO:6943 ! CC: | BP: | MF: [Term] id: NeXO:9256 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.57138529392856 density:0.0545790934320074 bootstrap:0.234233228 cc_score:0.0 bp_score:0.0420451 mf_score:0.0 relationship: child_of NeXO:9726 ! CC: | BP: | MF: [Term] id: NeXO:7539 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.1025825550844 density:0.924242424242424 bootstrap:0.64760343 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8183 ! CC: | BP: | MF: [Term] id: NeXO:7538 name: CC: | BP: galactose transport | MF:galactose transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. | MF_def:Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8089151 cc_score:0.0 bp_score:0.454213 mf_score:0.150132 relationship: child_of NeXO:8123 ! CC: | BP: glucose transport | MF:glucose transmembrane transporter activity relationship: linked_to NeXO:6907 ! CC: | BP: | MF:pentose transmembrane transporter activity relationship: linked_to NeXO:7533 ! CC: | BP: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: [Term] id: NeXO:7534 name: CC: | BP: regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26567283313537 density:0.111111111111111 bootstrap:0.388360187 cc_score:0.0 bp_score:0.107008 mf_score:0.0 relationship: child_of NeXO:8740 ! CC: | BP: | MF: [Term] id: NeXO:7537 name: CC: | BP: UDP-galactose transport | MF:UDP-galactose transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. | MF_def:Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.00548593995866 density:0.2 bootstrap:0.485970953 cc_score:0.0 bp_score:0.2125 mf_score:0.218064 relationship: child_of NeXO:8180 ! CC: | BP: | MF: [Term] id: NeXO:7536 name: CC: | BP: glycogen catabolic process | MF:glycogen phosphorylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. | MF_def:Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.446978615 cc_score:0.0 bp_score:0.116559 mf_score:0.31317 relationship: child_of NeXO:8138 ! CC: | BP: | MF: [Term] id: NeXO:7530 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.33816367908495 density:0.666666666666667 bootstrap:0.519841385 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7895 ! CC: | BP: | MF: relationship: linked_to NeXO:8769 ! CC: mitochondrial respiratory chain complex III | BP: mitochondrial electron transport, ubiquinol to cytochrome c | MF: [Term] id: NeXO:7533 name: CC: | BP: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.81883563968972 density:0.3 bootstrap:0.59607691 cc_score:0.0 bp_score:0.249892 mf_score:0.0 relationship: child_of NeXO:7534 ! CC: | BP: regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: [Term] id: NeXO:7532 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62144443273715 density:0.4 bootstrap:0.4732751 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8740 ! CC: | BP: | MF: [Term] id: NeXO:9527 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.1388621426216 density:0.59047619047619 bootstrap:0.65367225 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9795 ! CC: | BP: | MF: [Term] id: NeXO:9252 name: CC: | BP: purine ribonucleoside monophosphate biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.18301952837787 density:0.204761904761905 bootstrap:0.330408938 cc_score:0.0 bp_score:0.185486 mf_score:0.0406213 relationship: child_of NeXO:9653 ! CC: | BP: purine nucleoside monophosphate biosynthetic process | MF: [Term] id: NeXO:5276 name: CC: | BP: heme a biosynthetic process | MF:oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3. | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89735789 cc_score:0.0 bp_score:0.220618 mf_score:0.152081 relationship: child_of NeXO:5424 ! CC: | BP: mitochondrial tRNA thio-modification | MF:cysteine desulfurase activity [Term] id: NeXO:9521 name: CC: | BP: | MF:transcription from RNA polymerase I promoter def: "CC_def: | BP_def: | MF_def:The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:3.2990190841444 density:0.0526315789473684 bootstrap:0.131737002 cc_score:0.0 bp_score:0.0217755 mf_score:0.105059 relationship: child_of NeXO:9869 ! CC: | BP: | MF: [Term] id: NeXO:7059 name: CC: early endosome membrane | BP: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion | MF: def: "CC_def: The lipid bilayer surrounding an early endosome. | BP_def: Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.5202355 cc_score:0.177576 bp_score:0.147745 mf_score:0.0 relationship: child_of NeXO:7626 ! CC: | BP: | MF:mating-type factor pheromone receptor activity [Term] id: NeXO:9250 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.30104665 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9393 ! CC: | BP: | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:6178 name: CC: | BP: | MF:pantoate-beta-alanine ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.06592262453598 density:0.666666666666667 bootstrap:0.856634025 cc_score:0.0 bp_score:0.0562523 mf_score:0.313041 relationship: child_of NeXO:6782 ! CC: | BP: | MF: [Term] id: NeXO:6179 name: CC: | BP: | MF:oxidoreductase activity, acting on other nitrogenous compounds as donors def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:1.3282941681653 density:0.166666666666667 bootstrap:0.415219538 cc_score:0.0 bp_score:0.0 mf_score:0.117498 relationship: child_of NeXO:6501 ! CC: | BP: mitochondrial tRNA threonylcarbamoyladenosine modification | MF: [Term] id: NeXO:6176 name: CC: | BP: | MF:histidinol dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.403046869 cc_score:0.0 bp_score:0.0897784 mf_score:0.120557 relationship: child_of NeXO:6766 ! CC: | BP: | MF: [Term] id: NeXO:6177 name: CC: | BP: receptor-mediated endocytosis | MF:receptor-mediated endocytosis def: "CC_def: | BP_def: An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. | MF_def:An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [NeXO-GO:term] namespace: NeXO comment: robustness:2.86329404473016 density:0.666666666666667 bootstrap:0.747144906 cc_score:0.0 bp_score:0.128307 mf_score:0.150146 relationship: child_of NeXO:6212 ! CC: | BP: | MF: [Term] id: NeXO:9523 name: CC: | BP: | MF:cyclin binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [NeXO-GO:term] namespace: NeXO comment: robustness:1.05141453533556 density:0.333333333333333 bootstrap:0.223834496 cc_score:0.0 bp_score:0.0254336 mf_score:0.181591 relationship: child_of NeXO:9789 ! CC: | BP: regulation of exit from mitosis | MF:histone serine kinase activity relationship: linked_to NeXO:9216 ! CC: | BP: | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: relationship: linked_to NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: [Term] id: NeXO:6173 name: CC: | BP: tRNA 3'-trailer cleavage | MF: def: "CC_def: | BP_def: Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77969515 cc_score:0.0 bp_score:0.16215 mf_score:0.0 relationship: child_of NeXO:7973 ! CC: | BP: | MF: [Term] id: NeXO:6171 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.73002321149109 density:0.1 bootstrap:0.79958085 cc_score:0.0 bp_score:0.0569404 mf_score:0.0 relationship: child_of NeXO:7496 ! CC: | BP: | MF: [Term] id: NeXO:6778 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22463307793186 density:1 bootstrap:0.82004678 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8029 ! CC: | BP: | MF: [Term] id: NeXO:6779 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21895887204514 density:0.333333333333333 bootstrap:0.525573429 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7532 ! CC: | BP: | MF: [Term] id: NeXO:6774 name: CC: | BP: intracellular copper ion transport | MF:copper chaperone activity def: "CC_def: | BP_def: The directed movement of copper (Cu) ions within a cell. | MF_def:Assists in the delivery of copper ions to target proteins or compartments." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.378929218 cc_score:0.046636 bp_score:0.151661 mf_score:0.343963 relationship: child_of NeXO:7394 ! CC: | BP: | MF:metallochaperone activity [Term] id: NeXO:7227 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.95610248111836 density:0.444444444444444 bootstrap:0.480061699 cc_score:0.0699462 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8233 ! CC: | BP: | MF: [Term] id: NeXO:6777 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64456695 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7850 ! CC: | BP: regulation of mitochondrial translation | MF: [Term] id: NeXO:6770 name: CC: | BP: azole transport | MF:azole transporter activity def: "CC_def: | BP_def: The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24468780086096 density:0.133333333333333 bootstrap:0.677522881 cc_score:0.0 bp_score:0.169314 mf_score:0.143891 relationship: child_of NeXO:7751 ! CC: | BP: | MF: [Term] id: NeXO:6771 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82346552757489 density:0.6 bootstrap:0.473537175 cc_score:0.0 bp_score:0.0281438 mf_score:0.0 relationship: child_of NeXO:7666 ! CC: | BP: | MF: [Term] id: NeXO:6772 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1684680992831 density:0.7 bootstrap:0.7130217 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6922 ! CC: | BP: | MF: [Term] id: NeXO:6773 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.817543100022936 density:0.0476190476190476 bootstrap:0.221731839 cc_score:0.0 bp_score:0.0 mf_score:0.0801744 relationship: child_of NeXO:7377 ! CC: | BP: | MF: [Term] id: NeXO:5872 name: CC: Snt2C complex | BP: | MF: def: "CC_def: A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.623443066 cc_score:0.219746 bp_score:0.0 mf_score:0.09753 relationship: child_of NeXO:6605 ! CC: | BP: regulation of fatty acid metabolic process | MF: [Term] id: NeXO:5873 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19629168135695 density:1 bootstrap:0.7992854 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6559 ! CC: | BP: | MF: [Term] id: NeXO:5870 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.799826412 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6440 ! CC: | BP: | MF:mating-type a-factor pheromone receptor activity [Term] id: NeXO:5871 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35670376919839 density:1 bootstrap:0.920305123 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6829 ! CC: | BP: | MF: [Term] id: NeXO:5876 name: CC: transcription factor TFIIA complex | BP: | MF:TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly def: "CC_def: A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). | BP_def: | MF_def:Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35529260627933 density:1 bootstrap:0.91920332 cc_score:0.876187 bp_score:0.0333712 mf_score:0.354367 relationship: child_of NeXO:7929 ! CC: | BP: | MF:TBP-class protein binding [Term] id: NeXO:9961 name: CC: endoplasmic reticulum part | BP: glycosylation | MF: def: "CC_def: Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. | BP_def: The covalent attachment of a glycosyl residue to a substrate molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.6477777955379 density:0.161505161505162 bootstrap:0.424738011 cc_score:0.109839 bp_score:0.102738 mf_score:0.0791928 relationship: child_of NeXO:9993 ! CC: actin cytoskeleton | BP: | MF: [Term] id: NeXO:5874 name: CC: | BP: | MF:quinone binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [NeXO-GO:term] namespace: NeXO comment: robustness:3.97867266741904 density:1 bootstrap:0.87432843 cc_score:0.0 bp_score:0.0 mf_score:0.35198 relationship: child_of NeXO:6962 ! CC: | BP: | MF: [Term] id: NeXO:9963 name: CC: Golgi membrane | BP: | MF: def: "CC_def: The lipid bilayer surrounding any of the compartments of the Golgi apparatus. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.4409664547909 density:0.371764705882353 bootstrap:0.515438408 cc_score:0.108409 bp_score:0.0961128 mf_score:0.0285744 relationship: child_of NeXO:9965 ! CC: Golgi apparatus | BP: Golgi vesicle transport | MF: [Term] id: NeXO:5878 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89330494 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5879 ! CC: | BP: | MF: [Term] id: NeXO:5879 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83098904 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6045 ! CC: | BP: | MF: [Term] id: NeXO:7974 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.844361521235311 density:0.0666666666666667 bootstrap:0.213221931 cc_score:0.0 bp_score:0.0255281 mf_score:0.0 relationship: child_of NeXO:8721 ! CC: condensed nuclear chromosome, centromeric region | BP: microtubule polymerization or depolymerization | MF:tubulin binding [Term] id: NeXO:9969 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.0900895596045 density:0.220448179271709 bootstrap:0.233682565 cc_score:0.0 bp_score:0.0192643 mf_score:0.0226164 relationship: child_of NeXO:10016 ! CC: | BP: | MF: [Term] id: NeXO:5553 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32474866006962 density:1 bootstrap:0.89551705 cc_score:0.0 bp_score:0.0 mf_score:0.0602559 relationship: child_of NeXO:5770 ! CC: | BP: | MF: [Term] id: NeXO:5278 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.96105584 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6014 ! CC: | BP: | MF: [Term] id: NeXO:5279 name: CC: | BP: cysteinyl-tRNA aminoacylation | MF:cysteine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88625664 cc_score:0.0 bp_score:0.438808 mf_score:0.438664 relationship: child_of NeXO:5377 ! CC: | BP: | MF: [Term] id: NeXO:9483 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.78757309856538 density:1 bootstrap:0.632987889 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9667 ! CC: | BP: | MF: relationship: linked_to NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9314 ! CC: | BP: | MF: relationship: linked_to NeXO:9225 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:7695 name: CC: | BP: GPI anchor biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73363326234699 density:0.194444444444444 bootstrap:0.528650711 cc_score:0.0 bp_score:0.176353 mf_score:0.0 relationship: child_of NeXO:8743 ! CC: | BP: GPI anchor metabolic process | MF: [Term] id: NeXO:9481 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.66294565762763 density:0.8 bootstrap:0.301654304 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9539 ! CC: | BP: | MF: relationship: linked_to NeXO:9503 ! CC: | BP: | MF: relationship: linked_to NeXO:9321 ! CC: | BP: | MF: [Term] id: NeXO:5552 name: CC: cell surface | BP: | MF: def: "CC_def: The external part of the cell wall and/or plasma membrane. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92247117 cc_score:0.437673 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6456 ! CC: | BP: | MF: [Term] id: NeXO:8866 name: CC: | BP: 1-aminocyclopropane-1-carboxylate biosynthetic process | MF:1-aminocyclopropane-1-carboxylate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82893992 cc_score:0.0 bp_score:0.21895 mf_score:0.221625 relationship: child_of NeXO:9445 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: relationship: linked_to NeXO:8787 ! CC: | BP: | MF: [Term] id: NeXO:9487 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.06117583387845 density:0.0666666666666667 bootstrap:0.13063567 cc_score:0.0 bp_score:0.0140115 mf_score:0.0 relationship: child_of NeXO:9773 ! CC: | BP: | MF: [Term] id: NeXO:9486 name: CC: | BP: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: | BP_def: Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68566386245429 density:1 bootstrap:0.470829645 cc_score:0.0 bp_score:0.439205 mf_score:0.0 relationship: child_of NeXO:9851 ! CC: | BP: | MF: relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:9127 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: relationship: linked_to NeXO:9286 ! CC: | BP: | MF: relationship: linked_to NeXO:8912 ! CC: | BP: | MF: relationship: linked_to NeXO:8446 ! CC: | BP: | MF: relationship: linked_to NeXO:8983 ! CC: | BP: | MF: relationship: linked_to NeXO:7845 ! CC: | BP: | MF: relationship: linked_to NeXO:9235 ! CC: | BP: | MF: [Term] id: NeXO:6688 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05658349061439 density:0.0545454545454545 bootstrap:0.527148751 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6958 ! CC: | BP: | MF: [Term] id: NeXO:6689 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.8431499656647 density:1 bootstrap:0.56291548 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7251 ! CC: | BP: | MF: [Term] id: NeXO:6680 name: CC: | BP: siderophore metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93097472406394 density:0.333333333333333 bootstrap:0.75497443 cc_score:0.0 bp_score:0.312929 mf_score:0.0 relationship: child_of NeXO:7215 ! CC: | BP: nicotinamide riboside biosynthetic process | MF: [Term] id: NeXO:6681 name: CC: mitochondrial chromosome | BP: | MF:DNA strand annealing activity def: "CC_def: A chromosome found in the mitochondrion of a eukaryotic cell. | BP_def: | MF_def:Facilitates the base-pairing of complementary single-stranded DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.509402633 cc_score:0.219496 bp_score:0.0 mf_score:0.110026 relationship: child_of NeXO:7254 ! CC: | BP: prolyl-tRNA aminoacylation | MF:proline-tRNA ligase activity [Term] id: NeXO:6682 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.50536227 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7426 ! CC: | BP: betaine transport | MF: [Term] id: NeXO:9484 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.24750913729072 density:0.333333333333333 bootstrap:0.315113156 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9635 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:9393 ! CC: | BP: | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:9587 ! CC: | BP: | MF: relationship: linked_to NeXO:9224 ! CC: | BP: | MF: [Term] id: NeXO:6685 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.642578745 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6784 ! CC: | BP: | MF: [Term] id: NeXO:6686 name: CC: | BP: | MF:1,4-alpha-glucan branching enzyme activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76907854 cc_score:0.0 bp_score:0.0 mf_score:0.438232 relationship: child_of NeXO:7060 ! CC: | BP: | MF: [Term] id: NeXO:6687 name: CC: cell wall part | BP: | MF: def: "CC_def: Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.45833302399845 density:0.190476190476190 bootstrap:0.390506663 cc_score:0.167098 bp_score:0.0793432 mf_score:0.0 relationship: child_of NeXO:7543 ! CC: | BP: | MF: [Term] id: NeXO:9508 name: CC: | BP: | MF:ATP-dependent 3'-5' DNA helicase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [NeXO-GO:term] namespace: NeXO comment: robustness:4.73585598797631 density:1 bootstrap:0.619386221 cc_score:0.0 bp_score:0.0341892 mf_score:0.329349 relationship: child_of NeXO:9864 ! CC: DNA helicase complex | BP: vesicle transport along actin filament | MF:3'-5' DNA helicase activity relationship: linked_to NeXO:9312 ! CC: | BP: | MF: [Term] id: NeXO:7228 name: CC: | BP: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.745535928 cc_score:0.0 bp_score:0.193755 mf_score:0.0 relationship: child_of NeXO:8022 ! CC: | BP: | MF: [Term] id: NeXO:9503 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.65202080429297 density:1 bootstrap:0.59062732 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9793 ! CC: | BP: | MF: relationship: linked_to NeXO:9816 ! CC: | BP: | MF: relationship: linked_to NeXO:9560 ! CC: | BP: | MF: relationship: linked_to NeXO:9463 ! CC: | BP: | MF: relationship: linked_to NeXO:9768 ! CC: | BP: | MF: relationship: linked_to NeXO:9635 ! CC: | BP: | MF: [Term] id: NeXO:9500 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08362928685737 density:1 bootstrap:0.525197322 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9793 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:9393 ! CC: | BP: | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:9561 ! CC: | BP: | MF: relationship: linked_to NeXO:9483 ! CC: | BP: | MF: relationship: linked_to NeXO:9621 ! CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: relationship: linked_to NeXO:9224 ! CC: | BP: | MF: [Term] id: NeXO:9501 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.23890161958885 density:0.0476190476190476 bootstrap:0.509190609 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9560 ! CC: | BP: | MF: [Term] id: NeXO:9506 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.65240768989631 density:0.642857142857143 bootstrap:0.634664754 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9667 ! CC: | BP: | MF: [Term] id: NeXO:9507 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.7849129477714 density:0.361111111111111 bootstrap:0.402039859 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9663 ! CC: | BP: | MF: [Term] id: NeXO:9504 name: CC: Noc complex | BP: | MF: def: "CC_def: Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81699316775812 density:0.666666666666667 bootstrap:0.300870445 cc_score:0.115652 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9769 ! CC: | BP: ribosomal large subunit assembly | MF: relationship: linked_to NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:9741 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: relationship: linked_to NeXO:9251 ! CC: | BP: | MF: [Term] id: NeXO:9505 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.81197749505416 density:1 bootstrap:0.63945758 cc_score:0.0 bp_score:0.0994332 mf_score:0.0 relationship: child_of NeXO:9723 ! CC: | BP: | MF: relationship: linked_to NeXO:9891 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9808 ! CC: | BP: | MF: [Term] id: NeXO:7849 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.88204119772319 density:0.0384615384615385 bootstrap:0.50602681 cc_score:0.0 bp_score:0.044112 mf_score:0.0622937 relationship: child_of NeXO:8792 ! CC: | BP: | MF: [Term] id: NeXO:7848 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.604075139 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8446 ! CC: | BP: | MF: [Term] id: NeXO:7845 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75426052 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9187 ! CC: | BP: | MF: [Term] id: NeXO:7844 name: CC: | BP: 5-phosphoribose 1-diphosphate biosynthetic process | MF:ribose phosphate diphosphokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate. | MF_def:Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.5120155297764 density:1 bootstrap:0.83904534 cc_score:0.0 bp_score:0.715702 mf_score:0.72165 relationship: child_of NeXO:8526 ! CC: | BP: ribose phosphate biosynthetic process | MF:diphosphotransferase activity [Term] id: NeXO:7847 name: CC: | BP: | MF:U3 snoRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with U3 small nucleolar RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.539498218 cc_score:0.0 bp_score:0.0 mf_score:0.296357 relationship: child_of NeXO:8456 ! CC: | BP: | MF: [Term] id: NeXO:7841 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.50343321426601 density:0.111111111111111 bootstrap:0.385925334 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8355 ! CC: | BP: | MF: [Term] id: NeXO:7840 name: CC: phosphatidylinositol 3-kinase complex II | BP: inositol lipid-mediated signaling | MF: def: "CC_def: A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p. | BP_def: A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92009812869858 density:0.333333333333333 bootstrap:0.746493299 cc_score:0.324192 bp_score:0.173604 mf_score:0.0662492 relationship: child_of NeXO:8725 ! CC: phosphatidylinositol 3-kinase complex | BP: | MF: [Term] id: NeXO:7843 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.06373404253876 density:0.9 bootstrap:0.706877691 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8468 ! CC: | BP: peptidyl-tyrosine dephosphorylation | MF:protein tyrosine phosphatase activity [Term] id: NeXO:6274 name: CC: | BP: cellular response to water deprivation | MF:5-formyltetrahydrofolate cyclo-ligase activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water. | MF_def:Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.09649337878 density:1 bootstrap:0.72829753 cc_score:0.0 bp_score:0.220317 mf_score:0.443664 relationship: child_of NeXO:6914 ! CC: | BP: | MF: relationship: linked_to NeXO:6521 ! CC: | BP: negative regulation of transcription elongation from RNA polymerase II promoter | MF:glycine dehydrogenase (decarboxylating) activity [Term] id: NeXO:6356 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.096233623248 density:0.333333333333333 bootstrap:0.46904473 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6357 ! CC: | BP: | MF:aldo-keto reductase (NADP) activity [Term] id: NeXO:6357 name: CC: | BP: | MF:aldo-keto reductase (NADP) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.98955470762293 density:0.0897435897435897 bootstrap:0.431767247 cc_score:0.0 bp_score:0.0494496 mf_score:0.117148 relationship: child_of NeXO:7377 ! CC: | BP: | MF: [Term] id: NeXO:6354 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.443091243 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6356 ! CC: | BP: | MF: [Term] id: NeXO:6355 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.360821416 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6356 ! CC: | BP: | MF: [Term] id: NeXO:6352 name: CC: | BP: | MF:phosphodiesterase I activity def: "CC_def: | BP_def: | MF_def:Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [NeXO-GO:term] namespace: NeXO comment: robustness:3.3352931302245 density:0.5 bootstrap:0.73597962 cc_score:0.0 bp_score:0.0 mf_score:0.192929 relationship: child_of NeXO:7784 ! CC: | BP: aspartate family amino acid catabolic process | MF: [Term] id: NeXO:6350 name: CC: | BP: hydrogen peroxide metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93588752423828 density:0.333333333333333 bootstrap:0.75882094 cc_score:0.0 bp_score:0.1347 mf_score:0.0 relationship: child_of NeXO:6868 ! CC: | BP: | MF: [Term] id: NeXO:6351 name: CC: | BP: succinate transport | MF:succinate:fumarate antiporter activity def: "CC_def: | BP_def: The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87598367 cc_score:0.0 bp_score:0.441857 mf_score:0.4414 relationship: child_of NeXO:7000 ! CC: | BP: fumarate transport | MF:phosphoenolpyruvate carboxykinase (ATP) activity [Term] id: NeXO:6358 name: CC: | BP: dephosphorylation of RNA polymerase II C-terminal domain | MF: def: "CC_def: | BP_def: The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.558990793 cc_score:0.0 bp_score:0.220131 mf_score:0.0 relationship: child_of NeXO:7309 ! CC: | BP: positive regulation of protein dephosphorylation | MF: [Term] id: NeXO:6359 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.728384353 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6966 ! CC: | BP: | MF: [Term] id: NeXO:6194 name: CC: | BP: positive regulation of apoptosis | MF:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of cell death by apoptosis. | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.87314218190153 density:0.333333333333333 bootstrap:0.71042879 cc_score:0.0 bp_score:0.162179 mf_score:0.271019 relationship: child_of NeXO:6558 ! CC: | BP: | MF: [Term] id: NeXO:7992 name: CC: | BP: proton-transporting ATP synthase complex biogenesis | MF: def: "CC_def: | BP_def: The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.22088915770009 density:0.333333333333333 bootstrap:0.58200286 cc_score:0.0 bp_score:0.153563 mf_score:0.0 relationship: child_of NeXO:8702 ! CC: proton-transporting two-sector ATPase complex, proton-transporting domain | BP: ATP biosynthetic process | MF:cation-transporting ATPase activity [Term] id: NeXO:7991 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.73402285584685 density:1 bootstrap:0.54479088 cc_score:0.0 bp_score:0.074777 mf_score:0.0 relationship: child_of NeXO:8814 ! CC: | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding [Term] id: NeXO:6197 name: CC: | BP: phosphorylated carbohydrate dephosphorylation | MF: def: "CC_def: | BP_def: The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.65404738745641 density:0.333333333333333 bootstrap:0.75188642 cc_score:0.0 bp_score:0.11333 mf_score:0.0 relationship: child_of NeXO:7412 ! CC: | BP: cellular response to hypoxia | MF: [Term] id: NeXO:7997 name: CC: | BP: anti-apoptosis | MF: def: "CC_def: | BP_def: A process which directly inhibits any of the steps required for cell death by apoptosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27299963350827 density:1 bootstrap:0.856092275 cc_score:0.0 bp_score:0.219852 mf_score:0.0 relationship: child_of NeXO:8440 ! CC: | BP: negative regulation of cellular carbohydrate metabolic process | MF: relationship: linked_to NeXO:7437 ! CC: | BP: | MF: relationship: linked_to NeXO:5420 ! CC: | BP: | MF: [Term] id: NeXO:7996 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.61246779564688 density:1 bootstrap:0.430828025 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8517 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:9438 name: CC: | BP: positive regulation of phosphate metabolic process | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.04202697523946 density:0.242424242424242 bootstrap:0.262270969 cc_score:0.0 bp_score:0.112877 mf_score:0.0 relationship: child_of NeXO:9655 ! CC: | BP: | MF: [Term] id: NeXO:6193 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.17256032517992 density:0.0151515151515152 bootstrap:0.71527514 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7490 ! CC: | BP: | MF: [Term] id: NeXO:9436 name: CC: peroxisomal membrane | BP: protein targeting to peroxisome | MF: def: "CC_def: The lipid bilayer surrounding a peroxisome. | BP_def: The process of directing proteins towards the peroxisome, usually using signals contained within the protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.5867115191544 density:0.350806451612903 bootstrap:0.69574018 cc_score:0.39457 bp_score:0.406748 mf_score:0.0 relationship: child_of NeXO:9645 ! CC: peroxisomal part | BP: peroxisome organization | MF: [Term] id: NeXO:9437 name: CC: | BP: | MF:negative regulation of signal transduction def: "CC_def: | BP_def: | MF_def:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [NeXO-GO:term] namespace: NeXO comment: robustness:6.23884904969981 density:0.857142857142857 bootstrap:0.383672114 cc_score:0.0 bp_score:0.0787772 mf_score:0.153662 relationship: child_of NeXO:9640 ! CC: protein phosphatase type 2A complex | BP: mitotic cell cycle checkpoint | MF: [Term] id: NeXO:9434 name: CC: | BP: positive regulation of transcription regulatory region DNA binding | MF:core RNA polymerase II recruiting transcription factor activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. | MF_def:Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.350847998 cc_score:0.0 bp_score:0.167488 mf_score:0.203229 relationship: child_of NeXO:9778 ! CC: | BP: | MF: relationship: linked_to NeXO:8986 ! CC: | BP: transcriptional start site selection at RNA polymerase II promoter | MF: [Term] id: NeXO:7998 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.55095538069748 density:1 bootstrap:0.57196535 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8614 ! CC: | BP: protein import into peroxisome matrix, docking | MF:peroxisome matrix targeting signal-1 binding relationship: linked_to NeXO:8125 ! CC: | BP: ER-dependent peroxisome organization | MF: [Term] id: NeXO:9432 name: CC: | BP: mitotic cell cycle spindle checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.40119701080049 density:0.466666666666667 bootstrap:0.345389317 cc_score:0.0 bp_score:0.116308 mf_score:0.0 relationship: child_of NeXO:9727 ! CC: | BP: mitotic cell cycle G2/M transition decatenation checkpoint | MF: relationship: linked_to NeXO:8883 ! CC: microtubule plus end | BP: nuclear migration along microtubule | MF:microtubule plus-end binding [Term] id: NeXO:9433 name: CC: | BP: SNARE complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.3504559712018 density:0.466666666666667 bootstrap:0.474261082 cc_score:0.0383589 bp_score:0.268896 mf_score:0.0 relationship: child_of NeXO:9735 ! CC: endosomal part | BP: regulation of vacuole fusion, non-autophagic | MF: [Term] id: NeXO:9430 name: CC: | BP: | MF:Ran GTPase activator activity def: "CC_def: | BP_def: | MF_def:Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [NeXO-GO:term] namespace: NeXO comment: robustness:5.00529752736345 density:1 bootstrap:0.691869779 cc_score:0.0 bp_score:0.0436299 mf_score:0.219553 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport relationship: linked_to NeXO:9774 ! CC: | BP: regulation of protein desumoylation | MF: relationship: linked_to NeXO:8367 ! CC: | BP: | MF: relationship: linked_to NeXO:9092 ! CC: NDC1 complex | BP: mRNA export from nucleus in response to heat stress | MF: [Term] id: NeXO:9431 name: CC: dynein complex | BP: nuclear migration | MF:motor activity def: "CC_def: Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. | BP_def: The directed movement of the nucleus. | MF_def:Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:21.0286926520318 density:0.98901098901099 bootstrap:0.8207587 cc_score:0.370303 bp_score:0.286265 mf_score:0.225284 relationship: child_of NeXO:9728 ! CC: cytoplasmic microtubule | BP: microtubule-based movement | MF: [Term] id: NeXO:9616 name: CC: | BP: regulation of transcription termination, DNA-dependent | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate, extent, or location of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32773716966093 density:0.4 bootstrap:0.58888847 cc_score:0.0 bp_score:0.107314 mf_score:0.0 relationship: child_of NeXO:9799 ! CC: RNA cap binding complex | BP: | MF: relationship: linked_to NeXO:9788 ! CC: | BP: | MF: [Term] id: NeXO:9341 name: CC: heterotrimeric G-protein complex | BP: osmosensory signaling pathway via Sho1 osmosensor | MF:protein domain specific binding def: "CC_def: Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. | BP_def: A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system. | MF_def:Interacting selectively and non-covalently with a specific domain of a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:7.65870975982809 density:0.857142857142857 bootstrap:0.578179251 cc_score:0.180083 bp_score:0.165501 mf_score:0.1033 relationship: child_of NeXO:9791 ! CC: | BP: signal transduction involved in filamentous growth | MF:receptor signaling protein serine/threonine kinase activity [Term] id: NeXO:9614 name: CC: septin complex | BP: septin ring assembly | MF: def: "CC_def: Any of several heterooligomeric complexes containing multiple septins. | BP_def: The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.51426119575018 density:0.644444444444444 bootstrap:0.61216324 cc_score:0.318901 bp_score:0.273943 mf_score:0.0 relationship: child_of NeXO:9790 ! CC: septin ring | BP: septin ring organization | MF: [Term] id: NeXO:9615 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.21110310097754 density:1 bootstrap:0.63921722 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9879 ! CC: | BP: | MF: relationship: linked_to NeXO:9723 ! CC: | BP: | MF: relationship: linked_to NeXO:9503 ! CC: | BP: | MF: relationship: linked_to NeXO:9501 ! CC: | BP: | MF: relationship: linked_to NeXO:9741 ! CC: | BP: | MF: relationship: linked_to NeXO:9788 ! CC: | BP: | MF: [Term] id: NeXO:9344 name: CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.02860175983227 density:1 bootstrap:0.81855688 cc_score:0.0 bp_score:0.271684 mf_score:0.0 relationship: child_of NeXO:9862 ! CC: | BP: chitin biosynthetic process | MF: relationship: linked_to NeXO:9711 ! CC: actin filament | BP: negative regulation of actin filament polymerization | MF: relationship: linked_to NeXO:9584 ! CC: | BP: | MF: relationship: linked_to NeXO:9531 ! CC: | BP: | MF: relationship: linked_to NeXO:9530 ! CC: | BP: | MF: [Term] id: NeXO:9613 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.89380524000448 density:0.2 bootstrap:0.247817134 cc_score:0.0 bp_score:0.0237966 mf_score:0.0816161 relationship: child_of NeXO:9842 ! CC: | BP: | MF: [Term] id: NeXO:9610 name: CC: RSC complex | BP: nucleosome disassembly | MF:DNA-dependent ATPase activity def: "CC_def: A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. | BP_def: The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [NeXO-GO:term] namespace: NeXO comment: robustness:23.9865047836506 density:0.933333333333333 bootstrap:0.886942397 cc_score:0.680977 bp_score:0.638867 mf_score:0.143568 relationship: child_of NeXO:9686 ! CC: | BP: ATP-dependent chromatin remodeling | MF: [Term] id: NeXO:5299 name: CC: | BP: cytokinetic cell separation | MF: def: "CC_def: | BP_def: The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.20862524575343 density:1 bootstrap:0.80828759 cc_score:0.0 bp_score:0.101409 mf_score:0.0 relationship: child_of NeXO:5998 ! CC: | BP: | MF: [Term] id: NeXO:9348 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.36511091803028 density:0.333333333333333 bootstrap:0.309061232 cc_score:0.0 bp_score:0.0832433 mf_score:0.0 relationship: child_of NeXO:9709 ! CC: | BP: | MF: [Term] id: NeXO:5297 name: CC: | BP: regulation of ARF GTPase activity | MF: def: "CC_def: | BP_def: Any process that modulates the activity of the GTPase ARF. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86254777 cc_score:0.0 bp_score:0.127225 mf_score:0.0 relationship: child_of NeXO:6679 ! CC: | BP: | MF: [Term] id: NeXO:5295 name: CC: | BP: cristae formation | MF: def: "CC_def: | BP_def: The assembly of cristae, the inwards folds of the inner mitochondrial membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09050468363278 density:1 bootstrap:0.724142666 cc_score:0.0 bp_score:0.179203 mf_score:0.0 relationship: child_of NeXO:5296 ! CC: | BP: protein oligomerization | MF: [Term] id: NeXO:5292 name: CC: | BP: | MF:rRNA (guanine-N1-)-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.761823253 cc_score:0.0 bp_score:0.0 mf_score:0.442887 relationship: child_of NeXO:6218 ! CC: | BP: | MF: [Term] id: NeXO:5293 name: CC: | BP: superoxide metabolic process | MF:superoxide dismutase copper chaperone activity def: "CC_def: | BP_def: The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. | MF_def:A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83688561 cc_score:0.0 bp_score:0.213634 mf_score:0.443952 relationship: child_of NeXO:5984 ! CC: | BP: | MF:superoxide dismutase activity [Term] id: NeXO:5290 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.99805339174215 density:0.666666666666667 bootstrap:0.8191278 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7333 ! CC: | BP: | MF: [Term] id: NeXO:5291 name: CC: | BP: negative regulation of mitochondrial translation | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25120008139839 density:1 bootstrap:0.83975005 cc_score:0.0 bp_score:0.292425 mf_score:0.0 relationship: child_of NeXO:7794 ! CC: | BP: mitochondrial respiratory chain complex IV assembly | MF: relationship: linked_to NeXO:8573 ! CC: mitochondrial respiratory chain complex IV | BP: mitochondrial electron transport, cytochrome c to oxygen | MF:cytochrome-c oxidase activity [Term] id: NeXO:9186 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08430471855384 density:1 bootstrap:0.719853748 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9507 ! CC: | BP: | MF: relationship: linked_to NeXO:9286 ! CC: | BP: | MF: relationship: linked_to NeXO:9484 ! CC: | BP: | MF: relationship: linked_to NeXO:9127 ! CC: | BP: | MF: [Term] id: NeXO:9187 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.406231264 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9515 ! CC: | BP: | MF: [Term] id: NeXO:9184 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62958134724577 density:1 bootstrap:0.44002154 cc_score:0.0 bp_score:0.0304859 mf_score:0.0 relationship: child_of NeXO:9819 ! CC: | BP: regulation of spindle pole body separation | MF:cyclin-dependent protein kinase regulator activity relationship: linked_to NeXO:9213 ! CC: | BP: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:cyclin-dependent protein kinase inhibitor activity relationship: linked_to NeXO:8529 ! CC: | BP: meiotic G2/MI transition | MF: relationship: linked_to NeXO:7002 ! CC: | BP: | MF: relationship: linked_to NeXO:7097 ! CC: | BP: | MF: [Term] id: NeXO:9185 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.14420211888698 density:0.361111111111111 bootstrap:0.301580243 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9693 ! CC: | BP: | MF: [Term] id: NeXO:5058 name: CC: | BP: amino acid export from vacuole | MF:L-isoleucine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of amino acids out of the vacuole. | MF_def:Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.55520888 cc_score:0.0 bp_score:0.177913 mf_score:0.221867 relationship: child_of NeXO:5118 ! CC: | BP: amino acid export | MF:L-tyrosine transmembrane transporter activity [Term] id: NeXO:9183 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07907815143794 density:0.4 bootstrap:0.50416935 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9627 ! CC: | BP: | MF: relationship: linked_to NeXO:9496 ! CC: integral to endosome membrane | BP: Golgi to plasma membrane protein transport | MF: [Term] id: NeXO:9180 name: CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: def: "CC_def: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p. | BP_def: The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.6900463821984 density:1 bootstrap:0.74159919 cc_score:0.300754 bp_score:0.377564 mf_score:0.0 relationship: child_of NeXO:9603 ! CC: synaptonemal complex | BP: gene conversion at mating-type locus | MF:DNA secondary structure binding [Term] id: NeXO:5055 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91617673 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5400 ! CC: | BP: | MF: [Term] id: NeXO:5056 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92951131 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5156 ! CC: | BP: | MF:trans-hexaprenyltranstransferase activity [Term] id: NeXO:5057 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68453356 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5095 ! CC: | BP: | MF: [Term] id: NeXO:9188 name: CC: | BP: generation of catalytic spliceosome for second transesterification step | MF:second spliceosomal transesterification activity def: "CC_def: | BP_def: Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. | MF_def:Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [NeXO-GO:term] namespace: NeXO comment: robustness:8.36699015865655 density:0.761904761904762 bootstrap:0.80787912 cc_score:0.0956159 bp_score:0.27035 mf_score:0.193036 relationship: child_of NeXO:9985 ! CC: U2-type spliceosomal complex | BP: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | MF: [Term] id: NeXO:9189 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.2096870969091 density:0.133333333333333 bootstrap:0.196769676 cc_score:0.0 bp_score:0.0110088 mf_score:0.0896261 relationship: child_of NeXO:9555 ! CC: | BP: | MF: [Term] id: NeXO:9559 name: CC: | BP: | MF:RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [NeXO-GO:term] namespace: NeXO comment: robustness:12.2390851680947 density:1 bootstrap:0.55151096 cc_score:0.0 bp_score:0.0890858 mf_score:0.246823 relationship: child_of NeXO:9742 ! CC: core mediator complex | BP: | MF:RNA polymerase II transcription cofactor activity [Term] id: NeXO:7209 name: CC: | BP: acetate fermentation | MF:acetate-CoA ligase activity def: "CC_def: | BP_def: The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP. | MF_def:Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:3.07246882109159 density:0.666666666666667 bootstrap:0.86029601 cc_score:0.0 bp_score:0.314351 mf_score:0.23158 relationship: child_of NeXO:7210 ! CC: | BP: | MF: [Term] id: NeXO:7208 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.676241041 cc_score:0.0 bp_score:0.0593161 mf_score:0.0 relationship: child_of NeXO:7636 ! CC: | BP: negative regulation of transcription by competitive promoter binding | MF: [Term] id: NeXO:6944 name: CC: | BP: adenine metabolic process | MF:adenine deaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. | MF_def:Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58090992648906 density:0.333333333333333 bootstrap:0.50604987 cc_score:0.0 bp_score:0.345593 mf_score:0.314392 relationship: child_of NeXO:7525 ! CC: | BP: hypoxanthine salvage | MF: relationship: linked_to NeXO:7589 ! CC: | BP: | MF:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Term] id: NeXO:6379 name: CC: | BP: glutamyl-tRNA aminoacylation | MF: def: "CC_def: | BP_def: The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.710477521 cc_score:0.0 bp_score:0.200766 mf_score:0.0 relationship: child_of NeXO:7712 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7203 name: CC: exomer complex | BP: cell wall chitin biosynthetic process | MF: def: "CC_def: A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues. | BP_def: The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.02968867251429 density:0.666666666666667 bootstrap:0.83650578 cc_score:0.484013 bp_score:0.182014 mf_score:0.0 relationship: child_of NeXO:8640 ! CC: trans-Golgi network transport vesicle | BP: cell wall polysaccharide biosynthetic process | MF: [Term] id: NeXO:7202 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.310889238 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7697 ! CC: | BP: | MF: [Term] id: NeXO:7201 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.96915995350223 density:1 bootstrap:0.642515837 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7618 ! CC: | BP: | MF: relationship: linked_to NeXO:7202 ! CC: | BP: | MF: [Term] id: NeXO:7200 name: CC: | BP: | MF:phosphatidylinositol-4-phosphate binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52136735 cc_score:0.0 bp_score:0.0 mf_score:0.110137 relationship: child_of NeXO:7617 ! CC: | BP: N-glycan processing | MF: [Term] id: NeXO:7206 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68026855 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8325 ! CC: | BP: regulation of ion transport | MF:voltage-gated ion channel activity [Term] id: NeXO:7205 name: CC: | BP: mitochondrial citrate transport | MF:tricarboxylate secondary active transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion. | MF_def:Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72483704 cc_score:0.0 bp_score:0.297617 mf_score:0.297609 relationship: child_of NeXO:8259 ! CC: | BP: | MF: relationship: linked_to NeXO:7504 ! CC: | BP: | MF: relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity [Term] id: NeXO:7204 name: CC: | BP: | MF:amylo-alpha-1,6-glucosidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60813518 cc_score:0.0 bp_score:0.0670088 mf_score:0.314218 relationship: child_of NeXO:8106 ! CC: | BP: | MF:4-alpha-glucanotransferase activity relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:8259 ! CC: | BP: | MF: [Term] id: NeXO:6222 name: CC: | BP: | MF:aromatic-amino-acid:2-oxoglutarate aminotransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60576748 cc_score:0.0 bp_score:0.0 mf_score:0.168361 relationship: child_of NeXO:7926 ! CC: | BP: | MF:ligase activity, forming carbon-sulfur bonds [Term] id: NeXO:8637 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82628875710021 density:0.0201680672268908 bootstrap:0.194567839 cc_score:0.0 bp_score:0.0214882 mf_score:0.0 relationship: child_of NeXO:9405 ! CC: | BP: | MF: [Term] id: NeXO:6220 name: CC: | BP: isoleucyl-tRNA aminoacylation | MF:isoleucine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.683218416 cc_score:0.0 bp_score:0.182554 mf_score:0.192849 relationship: child_of NeXO:7609 ! CC: | BP: negative regulation of lipid metabolic process | MF: [Term] id: NeXO:6221 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.72173820019756 density:1 bootstrap:0.615698892 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6468 ! CC: | BP: | MF: [Term] id: NeXO:6226 name: CC: | BP: budding cell apical bud growth | MF: def: "CC_def: | BP_def: Growth at the tip of a bud, in a cell that reproduces by budding. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.15515059735989 density:0.666666666666667 bootstrap:0.80543247 cc_score:0.0 bp_score:0.180661 mf_score:0.0 relationship: child_of NeXO:6227 ! CC: | BP: | MF: [Term] id: NeXO:6227 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.44063586456372 density:0.190476190476190 bootstrap:0.76493484 cc_score:0.0 bp_score:0.0862527 mf_score:0.0 relationship: child_of NeXO:6573 ! CC: | BP: tRNA splicing, via endonucleolytic cleavage and ligation | MF:endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: NeXO:6224 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56963841 cc_score:0.0 bp_score:0.0 mf_score:0.0492562 relationship: child_of NeXO:6459 ! CC: | BP: | MF: [Term] id: NeXO:6225 name: CC: telomerase holoenzyme complex | BP: G-quadruplex DNA formation | MF:telomeric DNA binding def: "CC_def: Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. | BP_def: A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature. | MF_def:Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [NeXO-GO:term] namespace: NeXO comment: robustness:5.71755113743674 density:0.7 bootstrap:0.8725678 cc_score:0.400987 bp_score:0.212984 mf_score:0.187507 relationship: child_of NeXO:8233 ! CC: | BP: | MF: [Term] id: NeXO:5559 name: CC: | BP: uracil biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.20362947421223 density:1 bootstrap:0.804635134 cc_score:0.0 bp_score:0.443238 mf_score:0.0 relationship: child_of NeXO:6405 ! CC: | BP: proline catabolic process to glutamate | MF:proline dehydrogenase activity [Term] id: NeXO:6228 name: CC: | BP: polyadenylation-dependent snoRNA 3'-end processing | MF: def: "CC_def: | BP_def: Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.59811642251848 density:1 bootstrap:0.583881199 cc_score:0.0 bp_score:0.229048 mf_score:0.0 relationship: child_of NeXO:6979 ! CC: nuclear exosome (RNase complex) | BP: nuclear polyadenylation-dependent mRNA catabolic process | MF: [Term] id: NeXO:6229 name: CC: | BP: | MF:arginine transport def: "CC_def: | BP_def: | MF_def:The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.65992448 cc_score:0.0 bp_score:0.0 mf_score:0.156449 relationship: child_of NeXO:8053 ! CC: | BP: | MF: [Term] id: NeXO:8143 name: CC: | BP: citrate transport | MF:tricarboxylic acid transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [NeXO-GO:term] namespace: NeXO comment: robustness:1.33637717197157 density:0.333333333333333 bootstrap:0.361607277 cc_score:0.0 bp_score:0.165346 mf_score:0.167106 relationship: child_of NeXO:8734 ! CC: | BP: | MF: relationship: linked_to NeXO:7211 ! CC: | BP: | MF: [Term] id: NeXO:6997 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.531255513 cc_score:0.0 bp_score:0.0188643 mf_score:0.0806752 relationship: child_of NeXO:7974 ! CC: | BP: | MF: [Term] id: NeXO:8144 name: CC: | BP: mitochondrial tRNA modification | MF: def: "CC_def: | BP_def: The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.40256268946107 density:0.333333333333333 bootstrap:0.398312218 cc_score:0.0 bp_score:0.119475 mf_score:0.0 relationship: child_of NeXO:8714 ! CC: | BP: | MF: relationship: linked_to NeXO:8084 ! CC: | BP: charged-tRNA amino acid modification | MF: [Term] id: NeXO:9418 name: CC: | BP: inter-Golgi cisterna vesicle-mediated transport | MF: def: "CC_def: | BP_def: The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12719463577591 density:0.6 bootstrap:0.551759249 cc_score:0.0 bp_score:0.163694 mf_score:0.0 relationship: child_of NeXO:9695 ! CC: | BP: protein insertion into membrane | MF: relationship: linked_to NeXO:9270 ! CC: | BP: | MF: [Term] id: NeXO:9761 name: CC: cullin-RING ubiquitin ligase complex | BP: | MF: def: "CC_def: Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.69843748824806 density:0.0978260869565217 bootstrap:0.176148352 cc_score:0.135921 bp_score:0.075874 mf_score:0.0152763 relationship: child_of NeXO:9884 ! CC: | BP: | MF: [Term] id: NeXO:9766 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.01567494588175 density:0.00983969043670536 bootstrap:0.147438915 cc_score:0.0394389 bp_score:0.031476 mf_score:0.032167 relationship: child_of NeXO:9885 ! CC: | BP: | MF: [Term] id: NeXO:9767 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.82494848315467 density:0.0206388206388206 bootstrap:0.141511469 cc_score:0.0 bp_score:0.0856792 mf_score:0.0417381 relationship: child_of NeXO:9885 ! CC: | BP: | MF: [Term] id: NeXO:9764 name: CC: Rpd3L complex | BP: negative regulation of chromatin silencing at rDNA | MF:deacetylase activity def: "CC_def: A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae). | BP_def: Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin. | MF_def:Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:17.8126722688507 density:0.884615384615385 bootstrap:0.8123458 cc_score:0.559373 bp_score:0.475312 mf_score:0.110149 relationship: child_of NeXO:9777 ! CC: Sin3-type complex | BP: regulation of chromatin silencing at rDNA | MF: [Term] id: NeXO:9765 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30448452130398 density:0.0433403805496829 bootstrap:0.063564381 cc_score:0.0 bp_score:0.0258029 mf_score:0.0 relationship: child_of NeXO:9884 ! CC: | BP: | MF: [Term] id: NeXO:9768 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.5487569838877 density:0.861111111111111 bootstrap:0.638518512 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9904 ! CC: | BP: | MF: relationship: linked_to NeXO:9667 ! CC: | BP: | MF: relationship: linked_to NeXO:9809 ! CC: | BP: | MF: relationship: linked_to NeXO:9787 ! CC: | BP: | MF: [Term] id: NeXO:9769 name: CC: | BP: ribosomal large subunit assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.4410794556176 density:0.695652173913043 bootstrap:0.5154444 cc_score:0.0505068 bp_score:0.14182 mf_score:0.0827465 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: [Term] id: NeXO:5078 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.55547233 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5097 ! CC: | BP: | MF: [Term] id: NeXO:5331 name: CC: | BP: flocculation via cell wall protein-carbohydrate interaction | MF:mannose binding def: "CC_def: | BP_def: Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae. | MF_def:Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88293247 cc_score:0.0 bp_score:0.130895 mf_score:0.181059 relationship: child_of NeXO:6393 ! CC: | BP: | MF: [Term] id: NeXO:9292 name: CC: | BP: | MF:Ran guanyl-nucleotide exchange factor activity def: "CC_def: | BP_def: | MF_def:Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:1.22009087234875 density:1 bootstrap:0.246664246 cc_score:0.0 bp_score:0.0 mf_score:0.440031 relationship: child_of NeXO:9551 ! CC: | BP: | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:9091 ! CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: [Term] id: NeXO:9293 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.78842036192736 density:0.466666666666667 bootstrap:0.428510677 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9769 ! CC: | BP: ribosomal large subunit assembly | MF: [Term] id: NeXO:7335 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.48301472 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8045 ! CC: | BP: | MF: [Term] id: NeXO:9291 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.41816349790535 density:1 bootstrap:0.645332955 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9685 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: relationship: linked_to NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:9084 ! CC: | BP: regulation of histone H3-K36 methylation | MF: relationship: linked_to NeXO:8563 ! CC: | BP: | MF: relationship: linked_to NeXO:9741 ! CC: | BP: | MF: relationship: linked_to NeXO:9621 ! CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: [Term] id: NeXO:9296 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.71110814702615 density:0.393939393939394 bootstrap:0.192889442 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9527 ! CC: | BP: | MF: [Term] id: NeXO:9297 name: CC: CORVET complex | BP: regulation of vesicle fusion | MF: def: "CC_def: A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. | BP_def: Any process that modulates the frequency, rate or extent of vesicle fusion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.7657799642319 density:0.972222222222222 bootstrap:0.7847532 cc_score:0.278842 bp_score:0.401982 mf_score:0.0 relationship: child_of NeXO:9433 ! CC: | BP: SNARE complex assembly | MF: [Term] id: NeXO:7331 name: CC: | BP: ubiquitin-dependent endocytosis | MF:ubiquitin protein ligase binding def: "CC_def: | BP_def: Endocytosis of a protein that requires the substrate to be modified by uniquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded. | MF_def:Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:0.893478025603079 density:0.166666666666667 bootstrap:0.187869812 cc_score:0.0 bp_score:0.133693 mf_score:0.107972 relationship: child_of NeXO:7854 ! CC: | BP: | MF: [Term] id: NeXO:9295 name: CC: | BP: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF:LSU rRNA binding def: "CC_def: | BP_def: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. | MF_def:Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:7.1915444345241 density:1 bootstrap:0.571291857 cc_score:0.0 bp_score:0.146959 mf_score:0.125857 relationship: child_of NeXO:9600 ! CC: | BP: | MF: relationship: linked_to NeXO:9372 ! CC: | BP: | MF: [Term] id: NeXO:9298 name: CC: | BP: | MF:phosphatidylinositol phosphate 5-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the removal the of the 5-phosphate group of a phosphatidylinositol phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.03462671084533 density:0.277777777777778 bootstrap:0.224309756 cc_score:0.0 bp_score:0.0881595 mf_score:0.30208 relationship: child_of NeXO:9566 ! CC: | BP: | MF:phosphatidylinositol bisphosphate phosphatase activity [Term] id: NeXO:9299 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.852047287518503 density:0.0363636363636364 bootstrap:0.149654316 cc_score:0.0 bp_score:0.0 mf_score:0.0392689 relationship: child_of NeXO:9761 ! CC: cullin-RING ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:6995 name: CC: | BP: glycogen biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.5985851900607 density:0.2 bootstrap:0.81591513 cc_score:0.0 bp_score:0.199687 mf_score:0.0 relationship: child_of NeXO:8001 ! CC: | BP: glycogen (starch) synthase activity | MF:glycogen (starch) synthase activity [Term] id: NeXO:7339 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.64403231061364 density:1 bootstrap:0.87971814 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7843 ! CC: | BP: | MF: [Term] id: NeXO:7338 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.02316897965738 density:0.1 bootstrap:0.70546615 cc_score:0.0 bp_score:0.0 mf_score:0.0579951 relationship: child_of NeXO:8562 ! CC: | BP: | MF: [Term] id: NeXO:8859 name: CC: | BP: base-excision repair, base-free sugar-phosphate removal | MF: def: "CC_def: | BP_def: Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70031810681835 density:0.333333333333333 bootstrap:0.585382081 cc_score:0.0 bp_score:0.270248 mf_score:0.0677188 relationship: child_of NeXO:9156 ! CC: nuclear replisome | BP: DNA synthesis involved in DNA repair | MF: relationship: linked_to NeXO:8732 ! CC: | BP: response to hydroperoxide | MF: [Term] id: NeXO:8858 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89557287525642 density:0.333333333333333 bootstrap:0.727545294 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9308 ! CC: Elg1 RFC-like complex | BP: | MF: relationship: linked_to NeXO:9428 ! CC: | BP: DNA replication checkpoint | MF: [Term] id: NeXO:9557 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.14210587347427 density:0.377777777777778 bootstrap:0.352860676 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9670 ! CC: | BP: | MF: [Term] id: NeXO:8853 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.548467119 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9887 ! CC: small-subunit processome | BP: rRNA 5'-end processing | MF:snoRNA binding relationship: linked_to NeXO:9119 ! CC: | BP: | MF: [Term] id: NeXO:8852 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.0535867508064 density:1 bootstrap:0.698792048 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9293 ! CC: | BP: | MF: relationship: linked_to NeXO:9504 ! CC: Noc complex | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:8851 name: CC: | BP: cellular response to phosphate starvation | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.70389482203091 density:1 bootstrap:0.65559312 cc_score:0.0 bp_score:0.220682 mf_score:0.0866429 relationship: child_of NeXO:9438 ! CC: | BP: positive regulation of phosphate metabolic process | MF: [Term] id: NeXO:8850 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.87013644184564 density:0.0553846153846154 bootstrap:0.355794531 cc_score:0.0 bp_score:0.0514618 mf_score:0.0 relationship: child_of NeXO:9572 ! CC: | BP: | MF: [Term] id: NeXO:9631 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31196537740591 density:0.666666666666667 bootstrap:0.487119586 cc_score:0.0 bp_score:0.0 mf_score:0.0849275 relationship: child_of NeXO:9748 ! CC: | BP: | MF: relationship: linked_to NeXO:6077 ! CC: | BP: mitochondrial lysyl-tRNA aminoacylation | MF: relationship: linked_to NeXO:6959 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:5488 ! CC: | BP: | MF:acylglycerone-phosphate reductase activity [Term] id: NeXO:8854 name: CC: rDNA heterochromatin | BP: | MF: def: "CC_def: A region of heterochromatin located at the rDNA repeats in a chromosome. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.5913608503307 density:1 bootstrap:0.419622905 cc_score:0.226706 bp_score:0.0648317 mf_score:0.0 relationship: child_of NeXO:9261 ! CC: heterochromatin | BP: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9371 ! CC: | BP: | MF: relationship: linked_to NeXO:8752 ! CC: Noc4p-Nop14p complex | BP: | MF: relationship: linked_to NeXO:8457 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:5604 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8148095 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6087 ! CC: | BP: | MF: [Term] id: NeXO:5476 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85486854 cc_score:0.0 bp_score:0.0 mf_score:0.0348723 relationship: child_of NeXO:6756 ! CC: | BP: | MF: [Term] id: NeXO:5477 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82485688 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5754 ! CC: | BP: | MF: [Term] id: NeXO:5474 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85171995 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5701 ! CC: | BP: | MF: [Term] id: NeXO:5475 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81763944 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6447 ! CC: | BP: | MF: [Term] id: NeXO:5472 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.686852822 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5726 ! CC: | BP: | MF: [Term] id: NeXO:5473 name: CC: | BP: | MF:sterol esterase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [NeXO-GO:term] namespace: NeXO comment: robustness:1.67982897611275 density:0.1 bootstrap:0.75385646 cc_score:0.0 bp_score:0.0 mf_score:0.118614 relationship: child_of NeXO:5703 ! CC: | BP: acylglycerol metabolic process | MF:lysophosphatidylethanolamine acyltransferase activity [Term] id: NeXO:5470 name: CC: | BP: positive regulation of transcription involved in G2/M-phase of mitotic cell cycle | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M phase of the mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71662771 cc_score:0.0 bp_score:0.14149 mf_score:0.0 relationship: child_of NeXO:5707 ! CC: | BP: | MF: [Term] id: NeXO:5471 name: CC: | BP: plasma membrane pyruvate transport | MF:selenite:hydrogen symporter activity def: "CC_def: | BP_def: The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76804569 cc_score:0.0 bp_score:0.216868 mf_score:0.216871 relationship: child_of NeXO:5727 ! CC: | BP: plasma membrane lactate transport | MF:secondary active monocarboxylate transmembrane transporter activity [Term] id: NeXO:5478 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76622481 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6224 ! CC: | BP: | MF: [Term] id: NeXO:5479 name: CC: | BP: telomere maintenance via telomerase | MF:ATP-dependent DNA/RNA helicase activity def: "CC_def: | BP_def: The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex." [NeXO-GO:term] namespace: NeXO comment: robustness:3.49361581278393 density:0.5 bootstrap:0.80751028 cc_score:0.0 bp_score:0.149925 mf_score:0.250362 relationship: child_of NeXO:6225 ! CC: telomerase holoenzyme complex | BP: G-quadruplex DNA formation | MF:telomeric DNA binding [Term] id: NeXO:5274 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30842860806731 density:1 bootstrap:0.88298788 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6051 ! CC: | BP: | MF: [Term] id: NeXO:5275 name: CC: | BP: aldehyde catabolic process | MF:hydroxyacylglutathione hydrolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. | MF_def:Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90058139 cc_score:0.0 bp_score:0.115123 mf_score:0.293573 relationship: child_of NeXO:5453 ! CC: | BP: | MF: [Term] id: NeXO:7058 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.35789589610111 density:0.108333333333333 bootstrap:0.478559749 cc_score:0.0 bp_score:0.0814131 mf_score:0.0626219 relationship: child_of NeXO:8402 ! CC: | BP: | MF: [Term] id: NeXO:5277 name: CC: | BP: | MF:threo-3-hydroxyaspartate ammonia-lyase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.38115370081355 density:1 bootstrap:0.93949983 cc_score:0.0 bp_score:0.0 mf_score:0.444679 relationship: child_of NeXO:5398 ! CC: | BP: | MF:ammonia-lyase activity [Term] id: NeXO:5270 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88470788 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6021 ! CC: | BP: regulation of synaptonemal complex assembly | MF: [Term] id: NeXO:5271 name: CC: | BP: sulfite transport | MF:sulfite transport def: "CC_def: | BP_def: The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35227491269594 density:1 bootstrap:0.91684939 cc_score:0.0 bp_score:0.880241 mf_score:0.833333 relationship: child_of NeXO:6676 ! CC: | BP: | MF: [Term] id: NeXO:5272 name: CC: cellular bud scar | BP: | MF: def: "CC_def: Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77490129 cc_score:0.29667 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5443 ! CC: | BP: | MF: [Term] id: NeXO:5273 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82692585 cc_score:0.0 bp_score:0.0887388 mf_score:0.0 relationship: child_of NeXO:5465 ! CC: | BP: regulation of termination of mating projection growth | MF: [Term] id: NeXO:7052 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.6837323323596 density:0.4 bootstrap:0.489695526 cc_score:0.0 bp_score:0.0997971 mf_score:0.0795439 relationship: child_of NeXO:7069 ! CC: | BP: potassium ion transport | MF:metal ion transport [Term] id: NeXO:7053 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.86279396259734 density:1 bootstrap:0.82414052 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8021 ! CC: phosphopantothenoylcysteine decarboxylase complex | BP: coenzyme A biosynthetic process | MF:phosphopantothenoylcysteine decarboxylase activity [Term] id: NeXO:7050 name: CC: | BP: isoprenoid biosynthetic process | MF:hydroxymethylglutaryl-CoA synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. | MF_def:Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33654638156862 density:1 bootstrap:0.90462932 cc_score:0.0 bp_score:0.116958 mf_score:0.441476 relationship: child_of NeXO:7961 ! CC: | BP: | MF:diphosphomevalonate decarboxylase activity relationship: linked_to NeXO:8484 ! CC: | BP: positive regulation of translational elongation | MF: [Term] id: NeXO:7051 name: CC: | BP: post-chaperonin tubulin folding pathway | MF:tRNA (cytosine-5-)-methyltransferase activity def: "CC_def: | BP_def: Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77930099 cc_score:0.0 bp_score:0.295699 mf_score:0.30269 relationship: child_of NeXO:7785 ! CC: | BP: | MF:beta-tubulin binding relationship: linked_to NeXO:8398 ! CC: | BP: | MF: [Term] id: NeXO:7056 name: CC: | BP: | MF:choline kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.369769111 cc_score:0.0 bp_score:0.0594494 mf_score:0.294848 relationship: child_of NeXO:7691 ! CC: | BP: | MF: [Term] id: NeXO:7057 name: CC: | BP: phosphatidic acid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89267006028941 density:0.333333333333333 bootstrap:0.3823708 cc_score:0.0 bp_score:0.157149 mf_score:0.0749649 relationship: child_of NeXO:7074 ! CC: | BP: cardiolipin biosynthetic process | MF:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [Term] id: NeXO:7054 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.211503616 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7616 ! CC: | BP: | MF: [Term] id: NeXO:7055 name: CC: | BP: galactose metabolic process | MF:UDP-glucose 4-epimerase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. | MF_def:Catalysis of the reaction: UDP-glucose = UDP-galactose." [NeXO-GO:term] namespace: NeXO comment: robustness:5.22550265458161 density:0.466666666666667 bootstrap:0.815270013 cc_score:0.0 bp_score:0.334625 mf_score:0.13739 relationship: child_of NeXO:7151 ! CC: | BP: | MF: [Term] id: NeXO:5778 name: CC: ER-Golgi intermediate compartment membrane | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01149677108705 density:1 bootstrap:0.67044094 cc_score:0.29493 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7263 ! CC: | BP: vacuolar proton-transporting V-type ATPase complex assembly | MF: relationship: linked_to NeXO:7986 ! CC: vacuolar proton-transporting V-type ATPase, V1 domain | BP: intein-mediated protein splicing | MF: relationship: linked_to NeXO:8030 ! CC: | BP: | MF: [Term] id: NeXO:9026 name: CC: myosin complex | BP: | MF:microfilament motor activity def: "CC_def: A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. | BP_def: | MF_def:Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.44625148086415 density:0.476190476190476 bootstrap:0.623115702 cc_score:0.211761 bp_score:0.0893595 mf_score:0.161289 relationship: child_of NeXO:9662 ! CC: | BP: vesicle docking | MF: [Term] id: NeXO:8746 name: CC: | BP: RNA polymerase III transcriptional preinitiation complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.4659195570295 density:1 bootstrap:0.356075526 cc_score:0.0 bp_score:0.295454 mf_score:0.097507 relationship: child_of NeXO:9176 ! CC: | BP: | MF: [Term] id: NeXO:8149 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51943735891794 density:0.266666666666667 bootstrap:0.374655315 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8613 ! CC: | BP: | MF:ATP-dependent peptidase activity [Term] id: NeXO:8148 name: CC: luminal surveillance complex | BP: phytochelatin biosynthetic process | MF:oligosaccharide binding def: "CC_def: A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins. | BP_def: The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. | MF_def:Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [NeXO-GO:term] namespace: NeXO comment: robustness:3.72694805115223 density:1 bootstrap:0.7671934 cc_score:0.440156 bp_score:0.221683 mf_score:0.293486 relationship: child_of NeXO:8713 ! CC: | BP: cholesterol biosynthetic process | MF: relationship: linked_to NeXO:8910 ! CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity [Term] id: NeXO:6998 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.45156051662962 density:0.166666666666667 bootstrap:0.546732877 cc_score:0.0 bp_score:0.0708479 mf_score:0.0 relationship: child_of NeXO:8332 ! CC: ERMES complex | BP: protein import into mitochondrial outer membrane | MF: [Term] id: NeXO:6999 name: CC: mitochondrial respiratory chain complex II | BP: mitochondrial electron transport, succinate to ubiquinone | MF:succinate dehydrogenase (ubiquinone) activity def: "CC_def: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. | BP_def: The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. | MF_def:Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [NeXO-GO:term] namespace: NeXO comment: robustness:5.89554183438277 density:0.733333333333333 bootstrap:0.587348143 cc_score:0.659758 bp_score:0.656218 mf_score:0.579188 relationship: child_of NeXO:7168 ! CC: succinate dehydrogenase complex | BP: mitochondrial respiratory chain complex II assembly | MF:oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: NeXO:8639 name: CC: | BP: negative regulation of exit from mitosis | MF: def: "CC_def: | BP_def: Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.08492402385789 density:1 bootstrap:0.71405802 cc_score:0.0 bp_score:0.220414 mf_score:0.0 relationship: child_of NeXO:9138 ! CC: | BP: age-dependent response to oxidative stress | MF: [Term] id: NeXO:8638 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.55290799046685 density:1 bootstrap:0.57717302 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9132 ! CC: transcription factor TFIID complex | BP: | MF:sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [Term] id: NeXO:8141 name: CC: | BP: | MF:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.21672246922764 density:0.333333333333333 bootstrap:0.299752022 cc_score:0.0 bp_score:0.0174431 mf_score:0.323502 relationship: child_of NeXO:8655 ! CC: | BP: | MF:bis(5'-nucleosyl)-tetraphosphatase activity relationship: linked_to NeXO:9409 ! CC: | BP: | MF: [Term] id: NeXO:8140 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12834121782305 density:1 bootstrap:0.94134615 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9462 ! CC: | BP: tRNA wobble uridine modification | MF: relationship: linked_to NeXO:6747 ! CC: | BP: | MF: [Term] id: NeXO:8635 name: CC: | BP: | MF:dihydrofolate reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.0462579400111 density:1 bootstrap:0.69381327 cc_score:0.0 bp_score:0.0752039 mf_score:0.441212 relationship: child_of NeXO:9489 ! CC: | BP: | MF: relationship: linked_to NeXO:8897 ! CC: | BP: | MF:radical SAM enzyme activity relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: relationship: linked_to NeXO:7674 ! CC: | BP: | MF:borate efflux transmembrane transporter activity relationship: linked_to NeXO:7662 ! CC: | BP: | MF: [Term] id: NeXO:8634 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.41661758 cc_score:0.0 bp_score:0.0119267 mf_score:0.0 relationship: child_of NeXO:9488 ! CC: | BP: | MF: [Term] id: NeXO:8145 name: CC: | BP: unsaturated fatty acid biosynthetic process | MF:stearoyl-CoA 9-desaturase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. | MF_def:Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:3.45973688288836 density:1 bootstrap:0.66112613 cc_score:0.0 bp_score:0.659423 mf_score:0.299283 relationship: child_of NeXO:9162 ! CC: DNA polymerase complex | BP: cellular response to cold | MF:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water relationship: linked_to NeXO:8157 ! CC: | BP: | MF:cytidylyltransferase activity [Term] id: NeXO:8632 name: CC: | BP: spermidine metabolic process | MF:pantothenate kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. | MF_def:Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.27570485938012 density:0.666666666666667 bootstrap:0.500570355 cc_score:0.0 bp_score:0.139282 mf_score:0.199229 relationship: child_of NeXO:9221 ! CC: | BP: | MF: [Term] id: NeXO:6992 name: CC: | BP: regulation of sulfur metabolic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.86598873155245 density:0.5 bootstrap:0.606177032 cc_score:0.0 bp_score:0.291045 mf_score:0.0779387 relationship: child_of NeXO:7314 ! CC: | BP: regulation of cellular amino acid metabolic process | MF: [Term] id: NeXO:8630 name: CC: mitochondrial isocitrate dehydrogenase complex (NAD+) | BP: isocitrate metabolic process | MF:isocitrate dehydrogenase activity def: "CC_def: Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity. | BP_def: The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. | MF_def:Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:5.12064254625922 density:0.666666666666667 bootstrap:0.500829041 cc_score:0.304291 bp_score:0.454432 mf_score:0.457907 relationship: child_of NeXO:8691 ! CC: | BP: glutamate metabolic process | MF: [Term] id: NeXO:5519 name: CC: | BP: 1-phosphatidylinositol 4-kinase activity | MF:1-phosphatidylinositol 4-kinase activity def: "CC_def: | BP_def: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). | MF_def:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.31104307316673 density:1 bootstrap:0.88498911 cc_score:0.0 bp_score:0.175 mf_score:0.17706 relationship: child_of NeXO:7142 ! CC: | BP: | MF:[acyl-carrier-protein] S-acetyltransferase activity relationship: linked_to NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding [Term] id: NeXO:9955 name: CC: | BP: protein import into nucleus, translocation | MF: def: "CC_def: | BP_def: A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21360374137088 density:0.666666666666667 bootstrap:0.44655268 cc_score:0.0 bp_score:0.313096 mf_score:0.0 relationship: child_of NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: relationship: linked_to NeXO:5208 ! CC: | BP: | MF: relationship: linked_to NeXO:5186 ! CC: | BP: | MF:ketoreductase activity relationship: linked_to NeXO:5110 ! CC: | BP: | MF: relationship: linked_to NeXO:7489 ! CC: vacuolar lumen | BP: positive regulation of ubiquitin-dependent endocytosis | MF: relationship: linked_to NeXO:5706 ! CC: | BP: | MF: relationship: linked_to NeXO:7415 ! CC: | BP: negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:centromere-specific nucleosome binding relationship: linked_to NeXO:5818 ! CC: | BP: | MF: relationship: linked_to NeXO:5471 ! CC: | BP: plasma membrane pyruvate transport | MF:selenite:hydrogen symporter activity relationship: linked_to NeXO:5469 ! CC: | BP: | MF: relationship: linked_to NeXO:8645 ! CC: | BP: regulation of stress-activated MAPK cascade | MF:Hsp70 protein binding relationship: linked_to NeXO:9748 ! CC: | BP: | MF: [Term] id: NeXO:5802 name: CC: | BP: pentose-phosphate shunt | MF:ribulose-phosphate 3-epimerase activity def: "CC_def: | BP_def: The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. | MF_def:Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.03278782461829 density:0.333333333333333 bootstrap:0.83668728 cc_score:0.0 bp_score:0.106707 mf_score:0.318463 relationship: child_of NeXO:6823 ! CC: | BP: protein prenylation | MF:protein prenyltransferase activity [Term] id: NeXO:5511 name: CC: | BP: | MF:2-deoxyglucose-6-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.792395038 cc_score:0.0 bp_score:0.0 mf_score:0.297877 relationship: child_of NeXO:6199 ! CC: | BP: | MF: [Term] id: NeXO:5510 name: CC: | BP: | MF:triose-phosphate isomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.442546963 cc_score:0.0 bp_score:0.0 mf_score:0.442989 relationship: child_of NeXO:5745 ! CC: | BP: | MF:D-arabinono-1,4-lactone oxidase activity [Term] id: NeXO:5513 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07377834645354 density:1 bootstrap:0.712601148 cc_score:0.0 bp_score:0.0281017 mf_score:0.0 relationship: child_of NeXO:5514 ! CC: | BP: box H/ACA snoRNP assembly | MF: [Term] id: NeXO:5512 name: CC: | BP: 3-keto-sphinganine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70326111 cc_score:0.0 bp_score:0.293368 mf_score:0.0 relationship: child_of NeXO:6473 ! CC: | BP: negative regulation of sphingolipid biosynthetic process | MF: [Term] id: NeXO:5515 name: CC: voltage-gated potassium channel complex | BP: | MF:voltage-gated potassium channel activity def: "CC_def: A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. | BP_def: | MF_def:Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.880377641 cc_score:0.442795 bp_score:0.0 mf_score:0.444788 relationship: child_of NeXO:6078 ! CC: | BP: | MF:voltage-gated cation channel activity [Term] id: NeXO:5514 name: CC: | BP: box H/ACA snoRNP assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07521771909419 density:0.666666666666667 bootstrap:0.86183609 cc_score:0.0 bp_score:0.567601 mf_score:0.0 relationship: child_of NeXO:7177 ! CC: | BP: | MF: [Term] id: NeXO:5517 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.51831047 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5819 ! CC: | BP: | MF: [Term] id: NeXO:9956 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.25967120644732 density:0.141649048625793 bootstrap:0.200195474 cc_score:0.0991011 bp_score:0.0401337 mf_score:0.0 relationship: child_of NeXO:9967 ! CC: nuclear chromatin | BP: | MF: [Term] id: NeXO:9951 name: CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding def: "CC_def: The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. | BP_def: A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. | MF_def:Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [NeXO-GO:term] namespace: NeXO comment: robustness:20.0393142657836 density:0.118585858585859 bootstrap:0.54765466 cc_score:0.253574 bp_score:0.246185 mf_score:0.105996 relationship: child_of NeXO:10013 ! CC: chromosome | BP: chromatin organization | MF:DNA binding [Term] id: NeXO:8702 name: CC: proton-transporting two-sector ATPase complex, proton-transporting domain | BP: ATP biosynthetic process | MF:cation-transporting ATPase activity def: "CC_def: A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. | BP_def: The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:10.7644895605865 density:0.261904761904762 bootstrap:0.54057507 cc_score:0.22868 bp_score:0.330212 mf_score:0.284892 relationship: child_of NeXO:9452 ! CC: | BP: purine ribonucleoside triphosphate biosynthetic process | MF:hydrogen ion transmembrane transporter activity [Term] id: NeXO:8701 name: CC: mitochondrial proton-transporting ATP synthase complex | BP: ATP synthesis coupled proton transport | MF:hydrogen ion transporting ATP synthase activity, rotational mechanism def: "CC_def: A proton-transporting ATP synthase complex found in the mitochondrial membrane. | BP_def: The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:11.7123680156736 density:0.472527472527473 bootstrap:0.68868161 cc_score:0.569115 bp_score:0.625325 mf_score:0.424649 relationship: child_of NeXO:8702 ! CC: proton-transporting two-sector ATPase complex, proton-transporting domain | BP: ATP biosynthetic process | MF:cation-transporting ATPase activity [Term] id: NeXO:8700 name: CC: cellular bud neck septin collar | BP: asymmetric protein localization | MF: def: "CC_def: A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck. | BP_def: Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.428232313 cc_score:0.293656 bp_score:0.219103 mf_score:0.0 relationship: child_of NeXO:9216 ! CC: | BP: | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: [Term] id: NeXO:8706 name: CC: | BP: regulation of mitotic recombination | MF:NAD-dependent histone deacetylase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. | MF_def:Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [NeXO-GO:term] namespace: NeXO comment: robustness:3.2616803575729 density:0.194444444444444 bootstrap:0.403448684 cc_score:0.0 bp_score:0.114202 mf_score:0.106981 relationship: child_of NeXO:9586 ! CC: methyltransferase complex | BP: histone methylation | MF:histone methylation [Term] id: NeXO:8705 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.51173822151429 density:0.0439024390243902 bootstrap:0.27481663 cc_score:0.0 bp_score:0.0752292 mf_score:0.0699622 relationship: child_of NeXO:9478 ! CC: | BP: | MF: [Term] id: NeXO:8704 name: CC: | BP: transcription antitermination | MF:transcription antitermination def: "CC_def: | BP_def: Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site. | MF_def:Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54666451 cc_score:0.0 bp_score:0.299377 mf_score:0.281758 relationship: child_of NeXO:9434 ! CC: | BP: positive regulation of transcription regulatory region DNA binding | MF:core RNA polymerase II recruiting transcription factor activity relationship: linked_to NeXO:9551 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:8370 ! CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding [Term] id: NeXO:8709 name: CC: Rhp55-Rhp57 complex | BP: double-strand break repair via synthesis-dependent strand annealing | MF:protein heterodimerization activity def: "CC_def: A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces). | BP_def: SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. | MF_def:Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [NeXO-GO:term] namespace: NeXO comment: robustness:4.59981731222447 density:1 bootstrap:0.584313246 cc_score:0.437647 bp_score:0.560773 mf_score:0.17674 relationship: child_of NeXO:9009 ! CC: | BP: heteroduplex formation | MF:recombinase activity relationship: linked_to NeXO:9494 ! CC: checkpoint clamp complex | BP: mitotic cell cycle G1/S transition checkpoint | MF:exodeoxyribonuclease III activity [Term] id: NeXO:8708 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18987722612784 density:0.0474308300395257 bootstrap:0.178900266 cc_score:0.0 bp_score:0.0724811 mf_score:0.0341991 relationship: child_of NeXO:9542 ! CC: | BP: | MF: [Term] id: NeXO:7343 name: CC: nascent polypeptide-associated complex | BP: 'de novo' cotranslational protein folding | MF: def: "CC_def: A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. | BP_def: The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.42883064156693 density:0.166666666666667 bootstrap:0.480452834 cc_score:0.322829 bp_score:0.235231 mf_score:0.0 relationship: child_of NeXO:8128 ! CC: | BP: | MF: [Term] id: NeXO:8035 name: CC: | BP: | MF:DNA N-glycosylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [NeXO-GO:term] namespace: NeXO comment: robustness:3.0651582336962 density:0.181818181818182 bootstrap:0.258461368 cc_score:0.0 bp_score:0.0911847 mf_score:0.192336 relationship: child_of NeXO:8925 ! CC: | BP: | MF: [Term] id: NeXO:8034 name: CC: | BP: regulation of endocytosis | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of endocytosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87496898350061 density:0.333333333333333 bootstrap:0.711815172 cc_score:0.0 bp_score:0.139455 mf_score:0.0 relationship: child_of NeXO:8407 ! CC: | BP: | MF: relationship: linked_to NeXO:9757 ! CC: | BP: actin cortical patch localization | MF: relationship: linked_to NeXO:8547 ! CC: | BP: | MF: [Term] id: NeXO:8037 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60270574707691 density:1 bootstrap:0.42562726 cc_score:0.0 bp_score:0.0145737 mf_score:0.0 relationship: child_of NeXO:8690 ! CC: | BP: | MF: relationship: linked_to NeXO:7844 ! CC: | BP: 5-phosphoribose 1-diphosphate biosynthetic process | MF:ribose phosphate diphosphokinase activity [Term] id: NeXO:8031 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.34771193917689 density:0.133333333333333 bootstrap:0.244234058 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8367 ! CC: | BP: | MF: [Term] id: NeXO:8030 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.47090861373461 density:0.0952380952380952 bootstrap:0.320375656 cc_score:0.0 bp_score:0.0436951 mf_score:0.0 relationship: child_of NeXO:8938 ! CC: proton-transporting two-sector ATPase complex | BP: regulation of intracellular pH | MF:ATPase activity, coupled to transmembrane movement of ions [Term] id: NeXO:8033 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.485689056 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8333 ! CC: | BP: | MF:rRNA (uridine-2'-O-)-methyltransferase activity relationship: linked_to NeXO:9291 ! CC: | BP: | MF: [Term] id: NeXO:8032 name: CC: | BP: protein targeting to Golgi | MF: def: "CC_def: | BP_def: The process of directing proteins towards the Golgi; usually uses signals contained within the protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.660603352 cc_score:0.0 bp_score:0.294242 mf_score:0.0 relationship: child_of NeXO:8340 ! CC: Ric1p-Rgp1p complex | BP: | MF: relationship: linked_to NeXO:8780 ! CC: Golgi transport complex | BP: intra-Golgi vesicle-mediated transport | MF: [Term] id: NeXO:5138 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.41981107228207 density:1 bootstrap:0.97025249 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5796 ! CC: | BP: | MF: [Term] id: NeXO:5605 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89326334 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5606 ! CC: DNA helicase A complex | BP: | MF: [Term] id: NeXO:9998 name: CC: mitochondrial part | BP: localization | MF:transporter activity def: "CC_def: Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | BP_def: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location. | MF_def:Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [NeXO-GO:term] namespace: NeXO comment: robustness:11.2895173199065 density:0.00455788718500583 bootstrap:0.34864123 cc_score:0.190494 bp_score:0.14283 mf_score:0.116404 relationship: child_of NeXO:10034 ! CC: cell part | BP: cellular process | MF:binding [Term] id: NeXO:8529 name: CC: | BP: meiotic G2/MI transition | MF: def: "CC_def: | BP_def: The cell cycle process in which a cell progresses from meiotic prophase to metaphase I. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.65616399793792 density:1 bootstrap:0.7383283 cc_score:0.0 bp_score:0.292104 mf_score:0.0 relationship: child_of NeXO:9340 ! CC: | BP: | MF: relationship: linked_to NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: [Term] id: NeXO:5606 name: CC: DNA helicase A complex | BP: | MF: def: "CC_def: A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06852645995734 density:0.666666666666667 bootstrap:0.858089692 cc_score:0.314724 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6943 ! CC: | BP: | MF: [Term] id: NeXO:5600 name: CC: | BP: glucose 6-phosphate metabolic process | MF:glucokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. | MF_def:Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62644854 cc_score:0.0 bp_score:0.175536 mf_score:0.297431 relationship: child_of NeXO:5635 ! CC: | BP: | MF:glucose 6-phosphate metabolic process [Term] id: NeXO:5603 name: CC: | BP: cytidine transport | MF:cytidine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.29092509491026 density:1 bootstrap:0.869648247 cc_score:0.0 bp_score:0.447165 mf_score:0.447263 relationship: child_of NeXO:6594 ! CC: | BP: cytosine transport | MF:cytosine transport [Term] id: NeXO:5602 name: CC: | BP: GMP salvage | MF:guanine phosphoribosyltransferase activity def: "CC_def: | BP_def: Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. | MF_def:Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89220359 cc_score:0.0 bp_score:0.446557 mf_score:0.440222 relationship: child_of NeXO:6572 ! CC: | BP: IMP salvage | MF:hypoxanthine phosphoribosyltransferase activity [Term] id: NeXO:9991 name: CC: cortical actin cytoskeleton | BP: actin filament-based process | MF:cytoskeletal protein binding def: "CC_def: The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. | BP_def: Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. | MF_def:Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [NeXO-GO:term] namespace: NeXO comment: robustness:12.8171570987173 density:0.0825242718446602 bootstrap:0.224039446 cc_score:0.26491 bp_score:0.192124 mf_score:0.1679 relationship: child_of NeXO:9993 ! CC: actin cytoskeleton | BP: | MF: [Term] id: NeXO:9990 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.16582191305821 density:0.134502923976608 bootstrap:0.234353795 cc_score:0.0586349 bp_score:0.0819829 mf_score:0.0819439 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:9993 name: CC: actin cytoskeleton | BP: | MF: def: "CC_def: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.5382169219408 density:0.0596656833824975 bootstrap:0.419480667 cc_score:0.151138 bp_score:0.0942509 mf_score:0.0443269 relationship: child_of NeXO:9999 ! CC: site of polarized growth | BP: | MF: [Term] id: NeXO:8520 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35645670220754 density:1 bootstrap:0.62224337 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8920 ! CC: | BP: negative regulation of chromatin silencing at silent mating-type cassette | MF: relationship: linked_to NeXO:9624 ! CC: | BP: negative regulation of transcription during meiosis | MF: [Term] id: NeXO:8527 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.5036243938612 density:0.00584795321637427 bootstrap:0.232685318 cc_score:0.0 bp_score:0.0237818 mf_score:0.0455216 relationship: child_of NeXO:9572 ! CC: | BP: | MF: [Term] id: NeXO:5608 name: CC: | BP: peptidyl-lysine dimethylation | MF: def: "CC_def: | BP_def: The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32106724117651 density:1 bootstrap:0.892683055 cc_score:0.0 bp_score:0.22354 mf_score:0.0 relationship: child_of NeXO:6108 ! CC: | BP: | MF: [Term] id: NeXO:9997 name: CC: | BP: protein localization | MF:transport def: "CC_def: | BP_def: Any process in which a protein is transported to, or maintained in, a specific location. | MF_def:The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:11.3060977204173 density:0.0153239149802724 bootstrap:0.174327758 cc_score:0.0960747 bp_score:0.143086 mf_score:0.114615 relationship: child_of NeXO:10009 ! CC: | BP: cellular localization | MF: [Term] id: NeXO:8524 name: CC: | BP: | MF:glycerol-3-phosphate dehydrogenase [NAD+] activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.175611891 cc_score:0.0 bp_score:0.0702549 mf_score:0.138667 relationship: child_of NeXO:9374 ! CC: | BP: | MF: [Term] id: NeXO:6518 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.50725224 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7331 ! CC: | BP: ubiquitin-dependent endocytosis | MF:ubiquitin protein ligase binding [Term] id: NeXO:6519 name: CC: | BP: | MF:proton-dependent oligopeptide secondary active transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [NeXO-GO:term] namespace: NeXO comment: robustness:3.52035022638131 density:0.5 bootstrap:0.819916289 cc_score:0.0 bp_score:0.0535056 mf_score:0.253944 relationship: child_of NeXO:7905 ! CC: | BP: glutathione biosynthetic process | MF:glutathione synthase activity [Term] id: NeXO:9633 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.52292334385584 density:0.217948717948718 bootstrap:0.193739533 cc_score:0.0 bp_score:0.0566072 mf_score:0.0 relationship: child_of NeXO:9790 ! CC: septin ring | BP: septin ring organization | MF: [Term] id: NeXO:6510 name: CC: | BP: glycerol catabolic process | MF:glycerone kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. | MF_def:Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.61186069503337 density:0.666666666666667 bootstrap:0.62168868 cc_score:0.0 bp_score:0.293139 mf_score:0.566736 relationship: child_of NeXO:7564 ! CC: | BP: glycerol metabolic process | MF: [Term] id: NeXO:9634 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01314484470347 density:0.0359848484848485 bootstrap:0.111394557 cc_score:0.0 bp_score:0.0148907 mf_score:0.0232757 relationship: child_of NeXO:9827 ! CC: | BP: | MF: [Term] id: NeXO:6513 name: CC: | BP: activation of adenylate cyclase activity | MF: def: "CC_def: | BP_def: Any process that initiates the activity of the inactive enzyme adenylate cyclase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87177131 cc_score:0.0 bp_score:0.193047 mf_score:0.0 relationship: child_of NeXO:6874 ! CC: | BP: regulation of adenylate cyclase activity | MF: [Term] id: NeXO:6514 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06774134763589 density:1 bootstrap:0.708458265 cc_score:0.0654574 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8157 ! CC: | BP: | MF:cytidylyltransferase activity relationship: linked_to NeXO:9162 ! CC: DNA polymerase complex | BP: cellular response to cold | MF:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: NeXO:6515 name: CC: | BP: histidine transport | MF:high affinity L-histidine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.784326782 cc_score:0.0 bp_score:0.441909 mf_score:0.441044 relationship: child_of NeXO:7546 ! CC: | BP: | MF:Sar GTPase activator activity relationship: linked_to NeXO:9492 ! CC: ER to Golgi transport vesicle membrane | BP: COPII-coated vesicle budding | MF: [Term] id: NeXO:6516 name: CC: | BP: mitochondrial fission | MF: def: "CC_def: | BP_def: The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11502510252795 density:1 bootstrap:0.741229848 cc_score:0.0 bp_score:0.250587 mf_score:0.0364583 relationship: child_of NeXO:7320 ! CC: | BP: | MF: [Term] id: NeXO:9327 name: CC: | BP: positive regulation of lipid biosynthetic process | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62365694029035 density:0.833333333333333 bootstrap:0.462589282 cc_score:0.0 bp_score:0.198599 mf_score:0.0 relationship: child_of NeXO:9642 ! CC: | BP: | MF: relationship: linked_to NeXO:9257 ! CC: | BP: | MF: relationship: linked_to NeXO:9526 ! CC: | BP: | MF: relationship: linked_to NeXO:9326 ! CC: | BP: cellular amide catabolic process | MF:nucleobase:cation symporter activity [Term] id: NeXO:9636 name: CC: | BP: regulation of protein polymerization | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the process of creating protein polymers. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.19926104313565 density:0.132307692307692 bootstrap:0.494570252 cc_score:0.0 bp_score:0.209452 mf_score:0.0 relationship: child_of NeXO:9905 ! CC: actin cortical patch | BP: actin cytoskeleton organization | MF:actin binding [Term] id: NeXO:9637 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.63539179312053 density:0.0262096774193548 bootstrap:0.322224793 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10016 ! CC: | BP: | MF: [Term] id: NeXO:7971 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.1012989439874 density:0.5 bootstrap:0.63633386 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8970 ! CC: | BP: | MF: [Term] id: NeXO:8457 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39007165108727 density:0.666666666666667 bootstrap:0.520588753 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9119 ! CC: | BP: | MF: [Term] id: NeXO:8456 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.549189695 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8853 ! CC: | BP: | MF: [Term] id: NeXO:7585 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.4174315847548 density:0.4 bootstrap:0.7041897 cc_score:0.0 bp_score:0.0427268 mf_score:0.0 relationship: child_of NeXO:8053 ! CC: | BP: | MF: [Term] id: NeXO:8453 name: CC: | BP: protein autophosphorylation | MF: def: "CC_def: | BP_def: The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.207579668 cc_score:0.0 bp_score:0.105996 mf_score:0.0 relationship: child_of NeXO:9438 ! CC: | BP: positive regulation of phosphate metabolic process | MF: [Term] id: NeXO:8452 name: CC: | BP: coenzyme A metabolic process | MF:protein phosphatase inhibitor activity def: "CC_def: | BP_def: The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. | MF_def:Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:4.1456311880576 density:0.222222222222222 bootstrap:0.552341337 cc_score:0.0 bp_score:0.16017 mf_score:0.344559 relationship: child_of NeXO:8612 ! CC: | BP: | MF: [Term] id: NeXO:8451 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.20465647410854 density:0.236363636363636 bootstrap:0.349751125 cc_score:0.0442637 bp_score:0.0435491 mf_score:0.0 relationship: child_of NeXO:9276 ! CC: | BP: | MF: [Term] id: NeXO:8459 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.488145906 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8752 ! CC: Noc4p-Nop14p complex | BP: | MF: relationship: linked_to NeXO:8457 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:6427 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.514751378 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6428 ! CC: | BP: N-terminal peptidyl-proline dimethylation | MF:N-terminal protein N-methyltransferase activity [Term] id: NeXO:6420 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.499096458 cc_score:0.0 bp_score:0.0722676 mf_score:0.0 relationship: child_of NeXO:7464 ! CC: | BP: | MF: [Term] id: NeXO:6421 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.72040331763789 density:0.166666666666667 bootstrap:0.635220129 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6844 ! CC: | BP: | MF: [Term] id: NeXO:6422 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.301488066 cc_score:0.0 bp_score:0.0 mf_score:0.0142522 relationship: child_of NeXO:6940 ! CC: | BP: fatty acid beta-oxidation | MF:intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: NeXO:6423 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92827176624678 density:0.333333333333333 bootstrap:0.752862299 cc_score:0.0 bp_score:0.0948526 mf_score:0.0 relationship: child_of NeXO:6969 ! CC: | BP: sulfate transport | MF:secondary active sulfate transmembrane transporter activity [Term] id: NeXO:6428 name: CC: | BP: N-terminal peptidyl-proline dimethylation | MF:N-terminal protein N-methyltransferase activity def: "CC_def: | BP_def: The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [NeXO-GO:term] namespace: NeXO comment: robustness:2.86558664575419 density:0.5 bootstrap:0.543281429 cc_score:0.0 bp_score:0.2518 mf_score:0.251836 relationship: child_of NeXO:6918 ! CC: | BP: | MF: [Term] id: NeXO:6429 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.613682626 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7001 ! CC: | BP: | MF: [Term] id: NeXO:7264 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69190186 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8232 ! CC: | BP: cytoplasmic sequestering of protein | MF: [Term] id: NeXO:7540 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.81274238415189 density:0.090909090909091 bootstrap:0.52005405 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8681 ! CC: | BP: | MF: [Term] id: NeXO:7541 name: CC: proton-transporting two-sector ATPase complex, catalytic domain | BP: | MF: def: "CC_def: A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.17683457294996 density:1 bootstrap:0.63218317 cc_score:0.167596 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7830 ! CC: vacuolar proton-transporting V-type ATPase, V0 domain | BP: vacuolar acidification | MF: [Term] id: NeXO:7542 name: CC: mitochondrial pyruvate dehydrogenase complex | BP: acetyl-CoA biosynthetic process from pyruvate | MF:pyruvate dehydrogenase (acetyl-transferring) activity def: "CC_def: Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. | BP_def: The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. | MF_def:Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:3.97420878419447 density:1 bootstrap:0.87236762 cc_score:0.656805 bp_score:0.66514 mf_score:0.588523 relationship: child_of NeXO:8213 ! CC: | BP: acetyl-CoA biosynthetic process | MF:pyruvate dehydrogenase activity relationship: linked_to NeXO:6841 ! CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] synthase activity relationship: linked_to NeXO:6443 ! CC: | BP: protein lipoylation | MF:lipoate-protein ligase activity [Term] id: NeXO:7543 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.14380445448265 density:0.0888888888888889 bootstrap:0.373436888 cc_score:0.0688638 bp_score:0.070266 mf_score:0.0867088 relationship: child_of NeXO:8708 ! CC: | BP: | MF: [Term] id: NeXO:7544 name: CC: | BP: methionyl-tRNA aminoacylation | MF: def: "CC_def: | BP_def: The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.436951363 cc_score:0.0 bp_score:0.161346 mf_score:0.0 relationship: child_of NeXO:8939 ! CC: | BP: | MF: [Term] id: NeXO:7545 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.271616573 cc_score:0.0 bp_score:0.0167991 mf_score:0.0837513 relationship: child_of NeXO:8527 ! CC: | BP: | MF: [Term] id: NeXO:7546 name: CC: | BP: | MF:Sar GTPase activator activity def: "CC_def: | BP_def: | MF_def:Increases the rate of GTP hydrolysis by a GTPase of the Sar family." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.57765554 cc_score:0.0 bp_score:0.0662078 mf_score:0.206167 relationship: child_of NeXO:8593 ! CC: | BP: | MF: [Term] id: NeXO:7547 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93896074 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8095 ! CC: | BP: | MF:nucleocytoplasmic transporter activity [Term] id: NeXO:7995 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.42618257 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8299 ! CC: translocon complex | BP: | MF: [Term] id: NeXO:7587 name: CC: ubiquitin conjugating enzyme complex | BP: free ubiquitin chain polymerization | MF: def: "CC_def: Any complex that possesses ubiquitin conjugating enzyme activity. | BP_def: The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32373230454491 density:1 bootstrap:0.8947342 cc_score:0.875152 bp_score:0.587921 mf_score:0.0 relationship: child_of NeXO:9174 ! CC: | BP: | MF: relationship: linked_to NeXO:5825 ! CC: | BP: | MF:phosphoglycolate phosphatase activity relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:6981 ! CC: | BP: | MF: relationship: linked_to NeXO:8413 ! CC: | BP: | MF: relationship: linked_to NeXO:9173 ! CC: | BP: | MF: [Term] id: NeXO:6169 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.46914995898045 density:1 bootstrap:0.69343447 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6873 ! CC: | BP: | MF: [Term] id: NeXO:6168 name: CC: endoplasmic reticulum lumen | BP: cell redox homeostasis | MF:protein disulfide isomerase activity def: "CC_def: The volume enclosed by the membranes of the endoplasmic reticulum. | BP_def: Any process that maintains the redox environment of a cell or compartment within a cell. | MF_def:Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:5.16067999320885 density:0.6 bootstrap:0.86268765 cc_score:0.192784 bp_score:0.100116 mf_score:0.523892 relationship: child_of NeXO:6916 ! CC: | BP: | MF:protein disulfide oxidoreductase activity [Term] id: NeXO:6160 name: CC: | BP: cargo loading into COPII-coated vesicle | MF: def: "CC_def: | BP_def: The formation of a protein complex between the COPII coat proteins and proteins that are going to be transported by the COPII vesicle to the Golgi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.699930239 cc_score:0.0 bp_score:0.220612 mf_score:0.0 relationship: child_of NeXO:6452 ! CC: | BP: | MF: [Term] id: NeXO:6163 name: CC: | BP: | MF:cyclin-dependent protein kinase activating kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69947991 cc_score:0.0 bp_score:0.0 mf_score:0.31479 relationship: child_of NeXO:7359 ! CC: | BP: DNA replication preinitiation complex assembly | MF: [Term] id: NeXO:6162 name: CC: nuclear matrix | BP: actin filament severing | MF: def: "CC_def: The dense fibrillar network lying on the inner side of the nuclear membrane. | BP_def: The process in which an actin filament is broken down into smaller filaments. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91224759 cc_score:0.221799 bp_score:0.293981 mf_score:0.0 relationship: child_of NeXO:7694 ! CC: | BP: | MF:adenylate cyclase binding relationship: linked_to NeXO:9373 ! CC: | BP: positive regulation of actin filament bundle assembly | MF: [Term] id: NeXO:6165 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.819339882 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7107 ! CC: | BP: | MF: [Term] id: NeXO:6164 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.5256140272446 density:0.2 bootstrap:0.77073491 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7336 ! CC: | BP: | MF: [Term] id: NeXO:6167 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.707564579 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6845 ! CC: | BP: | MF: [Term] id: NeXO:6166 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.42701266431782 density:0.285714285714286 bootstrap:0.7734268 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7233 ! CC: | BP: | MF: [Term] id: NeXO:7994 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.387173624 cc_score:0.0 bp_score:0.0403015 mf_score:0.0 relationship: child_of NeXO:8889 ! CC: | BP: | MF: [Term] id: NeXO:6768 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04640807628586 density:0.133333333333333 bootstrap:0.5631143 cc_score:0.0 bp_score:0.0802274 mf_score:0.0 relationship: child_of NeXO:7881 ! CC: | BP: rRNA transcription | MF:RNA polymerase I regulatory region DNA binding [Term] id: NeXO:6766 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.763467268007342 density:0.00526315789473684 bootstrap:0.579513299 cc_score:0.0 bp_score:0.0885167 mf_score:0.0830184 relationship: child_of NeXO:8002 ! CC: | BP: | MF: [Term] id: NeXO:6765 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35065525847527 density:0.266666666666667 bootstrap:0.66265009 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7401 ! CC: | BP: | MF: [Term] id: NeXO:6764 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.31159138268956 density:0.090909090909091 bootstrap:0.60896003 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7859 ! CC: | BP: | MF: [Term] id: NeXO:6763 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.01700589598002 density:0.333333333333333 bootstrap:0.72725556 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6764 ! CC: | BP: | MF: [Term] id: NeXO:6762 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.77226907265592 density:0.266666666666667 bootstrap:0.83990486 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7236 ! CC: | BP: | MF: [Term] id: NeXO:6761 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.693261676700134 density:0.00526315789473684 bootstrap:0.47783389 cc_score:0.0 bp_score:0.0127807 mf_score:0.0409038 relationship: child_of NeXO:7981 ! CC: | BP: | MF: [Term] id: NeXO:6760 name: CC: | BP: | MF:phospholipase D activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.01682935403069 density:0.666666666666667 bootstrap:0.75270077 cc_score:0.0 bp_score:0.0 mf_score:0.251757 relationship: child_of NeXO:6973 ! CC: | BP: ascospore-type prospore membrane assembly | MF: [Term] id: NeXO:9977 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.27245499793628 density:0.00686128198594984 bootstrap:0.116580217 cc_score:0.0382569 bp_score:0.0507505 mf_score:0.0374874 relationship: child_of NeXO:9987 ! CC: | BP: | MF: [Term] id: NeXO:9976 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.03152810664171 density:0.00623727751970353 bootstrap:0.096276877 cc_score:0.045678 bp_score:0.0603234 mf_score:0.0485856 relationship: child_of NeXO:9987 ! CC: | BP: | MF: [Term] id: NeXO:9975 name: CC: | BP: regulation of ligase activity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.25953277949493 density:0.196969696969697 bootstrap:0.221683578 cc_score:0.0256791 bp_score:0.131171 mf_score:0.0881986 relationship: child_of NeXO:9990 ! CC: | BP: | MF: [Term] id: NeXO:9974 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5768224999544 density:0.0125324675324675 bootstrap:0.076185112 cc_score:0.0418034 bp_score:0.0568613 mf_score:0.0395552 relationship: child_of NeXO:9997 ! CC: | BP: protein localization | MF:transport [Term] id: NeXO:5869 name: CC: | BP: protein initiator methionine removal involved in protein maturation | MF:metalloaminopeptidase activity def: "CC_def: | BP_def: Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein. | MF_def:Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [NeXO-GO:term] namespace: NeXO comment: robustness:1.76474765146167 density:0.333333333333333 bootstrap:0.63058595 cc_score:0.0 bp_score:0.567978 mf_score:0.344339 relationship: child_of NeXO:6219 ! CC: | BP: box C/D snoRNA 3'-end processing | MF:metalloexopeptidase activity [Term] id: NeXO:9972 name: CC: | BP: transcription-coupled nucleotide-excision repair | MF:core RNA polymerase II binding transcription factor activity def: "CC_def: | BP_def: The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. | MF_def:Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [NeXO-GO:term] namespace: NeXO comment: robustness:11.7277493699274 density:0.292338709677419 bootstrap:0.237222216 cc_score:0.0423752 bp_score:0.157079 mf_score:0.127109 relationship: child_of NeXO:10014 ! CC: | BP: positive regulation of transcription elongation, DNA-dependent | MF: [Term] id: NeXO:9971 name: CC: | BP: protein refolding | MF: def: "CC_def: | BP_def: The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.86691270952268 density:0.161290322580645 bootstrap:0.231118445 cc_score:0.0 bp_score:0.131605 mf_score:0.0978042 relationship: child_of NeXO:10018 ! CC: | BP: | MF: [Term] id: NeXO:9970 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.06012530408771 density:0.00605502474962588 bootstrap:0.139263701 cc_score:0.0840084 bp_score:0.0655259 mf_score:0.0575805 relationship: child_of NeXO:10001 ! CC: membrane | BP: primary metabolic process | MF:metabolic process [Term] id: NeXO:5865 name: CC: | BP: | MF:uridylyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an uridylyl group to an acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:1.89771917274668 density:0.333333333333333 bootstrap:0.72919378 cc_score:0.0 bp_score:0.0809548 mf_score:0.133628 relationship: child_of NeXO:5992 ! CC: | BP: | MF: [Term] id: NeXO:5864 name: CC: | BP: UDP-glucose metabolic process | MF:UTP:glucose-1-phosphate uridylyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. | MF_def:Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85752624 cc_score:0.0 bp_score:0.222217 mf_score:0.300616 relationship: child_of NeXO:5865 ! CC: | BP: | MF:uridylyltransferase activity [Term] id: NeXO:5867 name: CC: | BP: | MF:alpha-1,3-mannosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80347599 cc_score:0.0 bp_score:0.0 mf_score:0.14693 relationship: child_of NeXO:6719 ! CC: | BP: | MF: [Term] id: NeXO:5866 name: CC: carboxy-terminal domain protein kinase complex | BP: positive regulation of translational fidelity | MF: def: "CC_def: A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. | BP_def: Any process that increases the ability of the translational apparatus to interpret the genetic code. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.36044186343235 density:1 bootstrap:0.923226929 cc_score:0.212572 bp_score:0.29526 mf_score:0.0 relationship: child_of NeXO:7376 ! CC: | BP: double-strand break repair via single-strand annealing, removal of nonhomologous ends | MF: [Term] id: NeXO:5861 name: CC: | BP: | MF:peptide-methionine-(S)-S-oxide reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68706105 cc_score:0.0 bp_score:0.0 mf_score:0.298294 relationship: child_of NeXO:6463 ! CC: | BP: | MF: relationship: linked_to NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity [Term] id: NeXO:5860 name: CC: | BP: maintenance of stationary phase in response to starvation | MF:demethylase activity def: "CC_def: | BP_def: The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment. | MF_def:Catalysis of the removal of a methyl group from a substrate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.17631872444164 density:1 bootstrap:0.784814185 cc_score:0.0 bp_score:0.438121 mf_score:0.131692 relationship: child_of NeXO:6056 ! CC: | BP: | MF: [Term] id: NeXO:5863 name: CC: | BP: negative regulation of glycogen biosynthetic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76848583 cc_score:0.0 bp_score:0.147887 mf_score:0.0 relationship: child_of NeXO:6782 ! CC: | BP: | MF: [Term] id: NeXO:9978 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.85654089753929 density:0.0144528814056711 bootstrap:0.08856781 cc_score:0.028099 bp_score:0.0820393 mf_score:0.0687578 relationship: child_of NeXO:9999 ! CC: site of polarized growth | BP: | MF: [Term] id: NeXO:6950 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86009955574684 density:0.333333333333333 bootstrap:0.70056985 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7420 ! CC: clathrin coat of trans-Golgi network vesicle | BP: | MF: relationship: linked_to NeXO:8819 ! CC: | BP: Golgi to endosome transport | MF: [Term] id: NeXO:8984 name: CC: tubulin complex | BP: nuclear migration involved in conjugation with cellular fusion | MF: def: "CC_def: A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. | BP_def: The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.59627738164508 density:0.166666666666667 bootstrap:0.599661227 cc_score:0.312424 bp_score:0.262508 mf_score:0.0 relationship: child_of NeXO:9835 ! CC: spindle pole body | BP: microtubule nucleation | MF:structural constituent of cytoskeleton relationship: linked_to NeXO:9668 ! CC: | BP: microtubule depolymerization | MF: [Term] id: NeXO:6951 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.52072844835177 density:0.5 bootstrap:0.82009248 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6952 ! CC: | BP: | MF: [Term] id: NeXO:9999 name: CC: site of polarized growth | BP: | MF: def: "CC_def: Any part of a cell where non-isotropic growth takes place. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.3536838885215 density:0.0185090461305295 bootstrap:0.208129693 cc_score:0.126803 bp_score:0.0974375 mf_score:0.0850906 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:8683 name: CC: | BP: formation of translation preinitiation complex | MF: def: "CC_def: | BP_def: The joining of the small ribosomal subunit, ternary complex, and mRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.332062425 cc_score:0.0 bp_score:0.128576 mf_score:0.0 relationship: child_of NeXO:9101 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7333 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04891225439045 density:0.2 bootstrap:0.507245016 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7777 ! CC: | BP: | MF: [Term] id: NeXO:5607 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88322502 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6097 ! CC: | BP: | MF: [Term] id: NeXO:7592 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.57913593686394 density:0.666666666666667 bootstrap:0.60620764 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8050 ! CC: | BP: | MF: [Term] id: NeXO:6699 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.91908923570921 density:0.2 bootstrap:0.445001431 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7076 ! CC: | BP: | MF: [Term] id: NeXO:8528 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.07322445888057 density:0.0545454545454545 bootstrap:0.143556088 cc_score:0.0 bp_score:0.0560549 mf_score:0.0 relationship: child_of NeXO:9234 ! CC: | BP: | MF: [Term] id: NeXO:5431 name: CC: | BP: D-xylose catabolic process | MF:glucose 1-dehydrogenase (NADP+) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide. | MF_def:Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:3.14872397023169 density:0.666666666666667 bootstrap:0.90352905 cc_score:0.0 bp_score:0.344612 mf_score:0.567823 relationship: child_of NeXO:5433 ! CC: | BP: arabinose catabolic process | MF:alditol:NADP+ 1-oxidoreductase activity [Term] id: NeXO:6693 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75568756 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7960 ! CC: | BP: hydroxymethylglutaryl-CoA reductase (NADPH) activity | MF:hydroxymethylglutaryl-CoA reductase (NADPH) activity [Term] id: NeXO:9854 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.6536244618951 density:0.00799349681614957 bootstrap:0.216206309 cc_score:0.021461 bp_score:0.0371763 mf_score:0.0276527 relationship: child_of NeXO:9998 ! CC: mitochondrial part | BP: localization | MF:transporter activity [Term] id: NeXO:6691 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91874826424783 density:0.666666666666667 bootstrap:0.776365484 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7748 ! CC: | BP: | MF: [Term] id: NeXO:6690 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.835278937 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6691 ! CC: | BP: | MF: [Term] id: NeXO:6697 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66095587038854 density:0.333333333333333 bootstrap:0.558592696 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6724 ! CC: | BP: amino acid catabolic process to alcohol via Ehrlich pathway | MF:alcohol dehydrogenase (NAD) activity [Term] id: NeXO:6696 name: CC: | BP: fructose metabolic process | MF:fructose-2,6-bisphosphate 2-phosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. | MF_def:Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.7004753680904 density:0.333333333333333 bootstrap:0.77842242 cc_score:0.0 bp_score:0.208769 mf_score:0.351297 relationship: child_of NeXO:7213 ! CC: | BP: D-xylose metabolic process | MF:sugar-phosphatase activity [Term] id: NeXO:6695 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.10571769212063 density:0.1 bootstrap:0.326623209 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7328 ! CC: | BP: | MF: [Term] id: NeXO:6694 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.854349171 cc_score:0.0 bp_score:0.027016 mf_score:0.0 relationship: child_of NeXO:6836 ! CC: | BP: | MF: [Term] id: NeXO:8684 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.7902148359846 density:0.666666666666667 bootstrap:0.709493183 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9317 ! CC: | BP: | MF: [Term] id: NeXO:6456 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.59594442015686 density:0.0666666666666667 bootstrap:0.76174661 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6764 ! CC: | BP: | MF: [Term] id: NeXO:7838 name: CC: monopolin complex | BP: homologous chromosome segregation | MF: def: "CC_def: A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits. | BP_def: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30999481019549 density:1 bootstrap:0.88418645 cc_score:0.438341 bp_score:0.196014 mf_score:0.0 relationship: child_of NeXO:8741 ! CC: | BP: protein localization to nucleolar rDNA repeats | MF:rDNA spacer replication fork barrier binding relationship: linked_to NeXO:8408 ! CC: | BP: | MF: relationship: linked_to NeXO:8554 ! CC: MCM complex | BP: | MF: relationship: linked_to NeXO:7725 ! CC: SMC loading complex | BP: meiotic chromosome condensation | MF: [Term] id: NeXO:8523 name: CC: | BP: tryptophan metabolic process | MF:anthranilate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. | MF_def:Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:7.39660897403247 density:0.454545454545455 bootstrap:0.474545782 cc_score:0.0 bp_score:0.175175 mf_score:0.148035 relationship: child_of NeXO:8927 ! CC: | BP: aromatic amino acid family biosynthetic process | MF:carbon-oxygen lyase activity, acting on phosphates [Term] id: NeXO:8135 name: CC: cAMP-dependent protein kinase complex | BP: cAMP-dependent protein kinase activity | MF: def: "CC_def: An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. | BP_def: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79515069560186 density:1 bootstrap:0.533978376 cc_score:0.437602 bp_score:0.583333 mf_score:0.0 relationship: child_of NeXO:9006 ! CC: | BP: | MF:cAMP-dependent protein kinase activity relationship: linked_to NeXO:7593 ! CC: | BP: pyruvate metabolic process | MF:pyruvate kinase activity [Term] id: NeXO:7830 name: CC: vacuolar proton-transporting V-type ATPase, V0 domain | BP: vacuolar acidification | MF: def: "CC_def: The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. | BP_def: Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.6605153672277 density:0.67948717948718 bootstrap:0.68261766 cc_score:0.27434 bp_score:0.355541 mf_score:0.0666553 relationship: child_of NeXO:8724 ! CC: vacuolar proton-transporting V-type ATPase complex | BP: ATP hydrolysis coupled proton transport | MF:proton transport [Term] id: NeXO:7832 name: CC: | BP: para-aminobenzoic acid biosynthetic process | MF:4-amino-4-deoxychorismate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins. | MF_def:Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.78973458786127 density:1 bootstrap:0.530761129 cc_score:0.0 bp_score:0.439076 mf_score:0.439749 relationship: child_of NeXO:8210 ! CC: | BP: isoleucine metabolic process | MF:dihydroxy-acid dehydratase activity relationship: linked_to NeXO:8877 ! CC: | BP: | MF: [Term] id: NeXO:7833 name: CC: HIR complex | BP: DNA replication-independent nucleosome assembly | MF: def: "CC_def: A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p. | BP_def: The formation of nucleosomes outside the context of DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94730585479014 density:1 bootstrap:0.86059682 cc_score:0.66669 bp_score:0.444595 mf_score:0.0 relationship: child_of NeXO:9247 ! CC: | BP: | MF: [Term] id: NeXO:7834 name: CC: | BP: negative regulation of ergosterol biosynthetic process | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75261981 cc_score:0.0 bp_score:0.440011 mf_score:0.0 relationship: child_of NeXO:8662 ! CC: | BP: regulation of cell shape during vegetative growth phase | MF: relationship: linked_to NeXO:5806 ! CC: | BP: | MF: relationship: linked_to NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: [Term] id: NeXO:7835 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.57435137668675 density:0.7 bootstrap:0.8294071 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7836 ! CC: | BP: peptide catabolic process | MF: [Term] id: NeXO:7836 name: CC: | BP: peptide catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.13947212126696 density:0.2 bootstrap:0.50708721 cc_score:0.0 bp_score:0.106421 mf_score:0.0839844 relationship: child_of NeXO:8843 ! CC: | BP: | MF: [Term] id: NeXO:7837 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.61839169569946 density:0.266666666666667 bootstrap:0.404663467 cc_score:0.0 bp_score:0.083693 mf_score:0.0 relationship: child_of NeXO:8586 ! CC: | BP: | MF: [Term] id: NeXO:6341 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.783025456 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7335 ! CC: | BP: | MF: [Term] id: NeXO:6340 name: CC: | BP: positive regulation of phosphatidylinositol biosynthetic process | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18292424406945 density:1 bootstrap:0.78958552 cc_score:0.0 bp_score:0.220869 mf_score:0.028288 relationship: child_of NeXO:7088 ! CC: | BP: | MF: relationship: linked_to NeXO:7532 ! CC: | BP: | MF: [Term] id: NeXO:6343 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.741243279 cc_score:0.0 bp_score:0.0 mf_score:0.047911 relationship: child_of NeXO:7135 ! CC: | BP: | MF: [Term] id: NeXO:6342 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.48279189 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6427 ! CC: | BP: | MF: [Term] id: NeXO:6345 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.697473321 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6995 ! CC: | BP: glycogen biosynthetic process | MF: [Term] id: NeXO:6344 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.464090187 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7068 ! CC: | BP: | MF: [Term] id: NeXO:6347 name: CC: | BP: flocculation | MF:monosaccharide binding def: "CC_def: | BP_def: The non-sexual aggregation of single-celled organisms. | MF_def:Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.471398402 cc_score:0.0 bp_score:0.112187 mf_score:0.103781 relationship: child_of NeXO:7138 ! CC: | BP: | MF: [Term] id: NeXO:6346 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99868699874418 density:1 bootstrap:0.66192902 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7518 ! CC: | BP: peptidyl-diphthamide biosynthetic process from peptidyl-histidine | MF: relationship: linked_to NeXO:9189 ! CC: | BP: | MF: [Term] id: NeXO:6349 name: CC: | BP: hydrogen peroxide catabolic process | MF:cytochrome-c peroxidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). | MF_def:Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76700706 cc_score:0.0 bp_score:0.223106 mf_score:0.440291 relationship: child_of NeXO:6350 ! CC: | BP: hydrogen peroxide metabolic process | MF: [Term] id: NeXO:5609 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90849136 cc_score:0.0 bp_score:0.0894504 mf_score:0.0 relationship: child_of NeXO:6554 ! CC: | BP: | MF: [Term] id: NeXO:8131 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.70054673273295 density:1 bootstrap:0.75636246 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9426 ! CC: | BP: | MF: relationship: linked_to NeXO:8563 ! CC: | BP: | MF: [Term] id: NeXO:6187 name: CC: | BP: | MF:ferrous iron binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with ferrous iron, Fe(II)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.44040413121802 density:0.5 bootstrap:0.78309904 cc_score:0.0 bp_score:0.0 mf_score:0.133942 relationship: child_of NeXO:6188 ! CC: | BP: iron-sulfur cluster assembly | MF: [Term] id: NeXO:9428 name: CC: | BP: DNA replication checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.58014511040057 density:1 bootstrap:0.579326027 cc_score:0.0 bp_score:0.178982 mf_score:0.0 relationship: child_of NeXO:9549 ! CC: replication fork protection complex | BP: replication fork protection | MF: relationship: linked_to NeXO:8930 ! CC: | BP: establishment of mitotic sister chromatid cohesion | MF: relationship: linked_to NeXO:9308 ! CC: Elg1 RFC-like complex | BP: | MF: relationship: linked_to NeXO:9009 ! CC: | BP: heteroduplex formation | MF:recombinase activity [Term] id: NeXO:6185 name: CC: | BP: peptidyl-lysine trimethylation | MF:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity def: "CC_def: | BP_def: The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. | MF_def:Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.626652936 cc_score:0.0 bp_score:0.296948 mf_score:0.439665 relationship: child_of NeXO:6466 ! CC: | BP: ornithine biosynthetic process | MF:ornithine carbamoyltransferase inhibitor activity [Term] id: NeXO:6184 name: CC: | BP: urea cycle | MF:argininosuccinate synthase activity def: "CC_def: | BP_def: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. | MF_def:Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.96035045170089 density:0.666666666666667 bootstrap:0.79865496 cc_score:0.0 bp_score:0.426109 mf_score:0.312962 relationship: child_of NeXO:6381 ! CC: | BP: urea metabolic process | MF:ornithine carbamoyltransferase activity [Term] id: NeXO:6183 name: CC: | BP: nicotinate nucleotide salvage | MF:nicotinamide mononucleotide transmembrane transporter activity def: "CC_def: | BP_def: The generation of nicotinate nucleotide without de novo synthesis. | MF_def:Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [NeXO-GO:term] namespace: NeXO comment: robustness:2.16626836745071 density:0.333333333333333 bootstrap:0.500909665 cc_score:0.0 bp_score:0.117037 mf_score:0.207346 relationship: child_of NeXO:6916 ! CC: | BP: | MF:protein disulfide oxidoreductase activity [Term] id: NeXO:8525 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08340975428404 density:1 bootstrap:0.525122544 cc_score:0.0 bp_score:0.0111629 mf_score:0.0 relationship: child_of NeXO:9144 ! CC: | BP: | MF: [Term] id: NeXO:6181 name: CC: | BP: calcium ion transport | MF:calcium ion transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:3.47220495326584 density:0.190476190476190 bootstrap:0.77903635 cc_score:0.0 bp_score:0.134271 mf_score:0.183828 relationship: child_of NeXO:7628 ! CC: | BP: | MF: [Term] id: NeXO:6180 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.84306128002566 density:0.166666666666667 bootstrap:0.79940857 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6181 ! CC: | BP: calcium ion transport | MF:calcium ion transmembrane transporter activity [Term] id: NeXO:9420 name: CC: kinetochore microtubule | BP: regulation of cell division | MF: def: "CC_def: Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. | BP_def: Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.8991482805937 density:0.533333333333333 bootstrap:0.384637729 cc_score:0.23835 bp_score:0.123832 mf_score:0.0 relationship: child_of NeXO:9886 ! CC: condensed nuclear chromosome kinetochore | BP: mitotic sister chromatid cohesion | MF: relationship: linked_to NeXO:6921 ! CC: | BP: mitotic spindle organization in nucleus | MF: [Term] id: NeXO:9423 name: CC: respiratory chain | BP: respiratory electron transport chain | MF: def: "CC_def: The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. | BP_def: A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.0266247325301 density:0.467692307692308 bootstrap:0.466466812 cc_score:0.139467 bp_score:0.127431 mf_score:0.0271842 relationship: child_of NeXO:9424 ! CC: | BP: | MF: [Term] id: NeXO:9422 name: CC: Golgi stack | BP: | MF: def: "CC_def: The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.88109584367438 density:0.466666666666667 bootstrap:0.449732278 cc_score:0.111427 bp_score:0.012557 mf_score:0.0 relationship: child_of NeXO:9913 ! CC: | BP: | MF: relationship: linked_to NeXO:8207 ! CC: | BP: | MF: [Term] id: NeXO:9425 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.6916089941217 density:0.256921373200443 bootstrap:0.476468781 cc_score:0.0 bp_score:0.0212926 mf_score:0.0 relationship: child_of NeXO:9797 ! CC: | BP: cofactor catabolic process | MF: [Term] id: NeXO:9424 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:23.4134956052975 density:0.560919540229885 bootstrap:0.7476074 cc_score:0.0 bp_score:0.0815066 mf_score:0.0242305 relationship: child_of NeXO:9781 ! CC: mitochondrial matrix | BP: oxidative phosphorylation | MF:monovalent inorganic cation transmembrane transporter activity [Term] id: NeXO:6189 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.86183339374753 density:0.666666666666667 bootstrap:0.746382819 cc_score:0.0 bp_score:0.0921473 mf_score:0.0 relationship: child_of NeXO:6190 ! CC: | BP: | MF:phosphoglycerate dehydrogenase activity [Term] id: NeXO:9426 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.46378483813675 density:0.666666666666667 bootstrap:0.72269565 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: [Term] id: NeXO:9353 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.91263973116361 density:0.2 bootstrap:0.373605687 cc_score:0.0 bp_score:0.0 mf_score:0.0564598 relationship: child_of NeXO:9606 ! CC: | BP: | MF: [Term] id: NeXO:9352 name: CC: nuclear origin of replication recognition complex | BP: pre-replicative complex assembly | MF: def: "CC_def: A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. | BP_def: The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.16285678353565 density:0.904761904761905 bootstrap:0.60946859 cc_score:0.347505 bp_score:0.213518 mf_score:0.0 relationship: child_of NeXO:9700 ! CC: pre-replicative complex | BP: progressive alteration of chromatin involved in replicative cell aging | MF: [Term] id: NeXO:9351 name: CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity def: "CC_def: | BP_def: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase. | MF_def:Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [NeXO-GO:term] namespace: NeXO comment: robustness:5.06071074669506 density:1 bootstrap:0.70727384 cc_score:0.0 bp_score:0.17858 mf_score:0.2221 relationship: child_of NeXO:9789 ! CC: | BP: regulation of exit from mitosis | MF:histone serine kinase activity relationship: linked_to NeXO:9341 ! CC: heterotrimeric G-protein complex | BP: osmosensory signaling pathway via Sho1 osmosensor | MF:protein domain specific binding relationship: linked_to NeXO:8967 ! CC: | BP: | MF:Ras GTPase binding [Term] id: NeXO:9350 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.77033291348315 density:0.333333333333333 bootstrap:0.634583758 cc_score:0.0 bp_score:0.056932 mf_score:0.0 relationship: child_of NeXO:9697 ! CC: | BP: | MF: [Term] id: NeXO:9357 name: CC: | BP: positive regulation of transposition, RNA-mediated | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.40300017 cc_score:0.0 bp_score:0.316325 mf_score:0.0 relationship: child_of NeXO:9711 ! CC: actin filament | BP: negative regulation of actin filament polymerization | MF: relationship: linked_to NeXO:9365 ! CC: | BP: galactose catabolic process | MF: [Term] id: NeXO:9356 name: CC: prefoldin complex | BP: tubulin complex assembly | MF: def: "CC_def: A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. | BP_def: The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.42354482708899 density:1 bootstrap:0.81232727 cc_score:0.500792 bp_score:0.598507 mf_score:0.0 relationship: child_of NeXO:9836 ! CC: filamentous actin | BP: tubulin complex biogenesis | MF: [Term] id: NeXO:9607 name: CC: | BP: activation of anaphase-promoting complex activity involved in meiotic cell cycle | MF:anaphase-promoting complex binding def: "CC_def: | BP_def: Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle. | MF_def:Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [NeXO-GO:term] namespace: NeXO comment: robustness:2.95869715958776 density:1 bootstrap:0.48350304 cc_score:0.0 bp_score:0.298164 mf_score:0.223139 relationship: child_of NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding relationship: linked_to NeXO:9121 ! CC: mitotic checkpoint complex | BP: | MF: relationship: linked_to NeXO:9571 ! CC: | BP: DNA damage induced protein phosphorylation | MF:histone phosphorylation relationship: linked_to NeXO:9152 ! CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: [Term] id: NeXO:9354 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.21029005152465 density:0.333333333333333 bootstrap:0.296591016 cc_score:0.0 bp_score:0.0590891 mf_score:0.0 relationship: child_of NeXO:9548 ! CC: | BP: | MF: relationship: linked_to NeXO:8324 ! CC: | BP: | MF: relationship: linked_to NeXO:8650 ! CC: condensed nuclear chromosome outer kinetochore | BP: establishment of meiotic sister chromatid cohesion | MF: relationship: linked_to NeXO:8201 ! CC: | BP: | MF: [Term] id: NeXO:9609 name: CC: mitochondrial ribosome | BP: regulation of pH | MF: def: "CC_def: A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. | BP_def: Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.9326871342091 density:0.175084175084175 bootstrap:0.304100411 cc_score:0.20175 bp_score:0.199057 mf_score:0.0987337 relationship: child_of NeXO:9883 ! CC: large ribosomal subunit | BP: cellular monovalent inorganic cation homeostasis | MF: [Term] id: NeXO:9608 name: CC: proteasome core complex | BP: proteasomal ubiquitin-independent protein catabolic process | MF:threonine-type endopeptidase activity def: "CC_def: A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin. | MF_def:Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [NeXO-GO:term] namespace: NeXO comment: robustness:20.0413768243532 density:0.833333333333333 bootstrap:0.72766909 cc_score:0.64693 bp_score:0.583667 mf_score:0.579395 relationship: child_of NeXO:9901 ! CC: proteasome complex | BP: proteasome assembly | MF: [Term] id: NeXO:5283 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28198641692578 density:1 bootstrap:0.86287514 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6013 ! CC: | BP: | MF: [Term] id: NeXO:9358 name: CC: | BP: regulation of growth | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90874661374914 density:0.120879120879121 bootstrap:0.241224198 cc_score:0.0 bp_score:0.136821 mf_score:0.0 relationship: child_of NeXO:9554 ! CC: | BP: TOR signaling cascade | MF: [Term] id: NeXO:5285 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.888910411 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6012 ! CC: | BP: | MF: [Term] id: NeXO:5284 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30015416368267 density:1 bootstrap:0.876669175 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5436 ! CC: | BP: | MF:alcohol transmembrane transporter activity [Term] id: NeXO:5287 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91800409 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5371 ! CC: | BP: | MF: [Term] id: NeXO:5286 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.34253730417326 density:1 bootstrap:0.90927422 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5996 ! CC: | BP: | MF: [Term] id: NeXO:9191 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.77614681261092 density:0.333333333333333 bootstrap:0.336738379 cc_score:0.0 bp_score:0.0618725 mf_score:0.0 relationship: child_of NeXO:9516 ! CC: | BP: | MF: [Term] id: NeXO:9190 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10912184886901 density:0.026890756302521 bootstrap:0.16770854 cc_score:0.0 bp_score:0.0303027 mf_score:0.0 relationship: child_of NeXO:9645 ! CC: peroxisomal part | BP: peroxisome organization | MF: [Term] id: NeXO:9193 name: CC: nucleotide-excision repair factor 2 complex | BP: protein deglycosylation | MF: def: "CC_def: One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. | BP_def: The removal of sugar residues from a glycosylated protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.40432156917147 density:1 bootstrap:0.326779632 cc_score:0.22079 bp_score:0.291864 mf_score:0.0 relationship: child_of NeXO:9604 ! CC: | BP: | MF: relationship: linked_to NeXO:9133 ! CC: | BP: positive regulation of sequence-specific DNA binding transcription factor activity | MF: relationship: linked_to NeXO:8875 ! CC: | BP: | MF: relationship: linked_to NeXO:9180 ! CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: [Term] id: NeXO:7947 name: CC: CAF-1 complex | BP: | MF: def: "CC_def: A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53685550665084 density:0.666666666666667 bootstrap:0.58649512 cc_score:0.430811 bp_score:0.0131247 mf_score:0.0 relationship: child_of NeXO:8660 ! CC: | BP: | MF: [Term] id: NeXO:9195 name: CC: | BP: regulation of S phase | MF: def: "CC_def: | BP_def: A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.4411381182827 density:0.911111111111111 bootstrap:0.657078753 cc_score:0.0 bp_score:0.111483 mf_score:0.0 relationship: child_of NeXO:9474 ! CC: | BP: transcription elongation from RNA polymerase II promoter | MF: [Term] id: NeXO:7941 name: CC: | BP: attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation | MF: def: "CC_def: | BP_def: The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90749388162212 density:0.333333333333333 bootstrap:0.73672494 cc_score:0.0 bp_score:0.204475 mf_score:0.0 relationship: child_of NeXO:9804 ! CC: | BP: | MF: relationship: linked_to NeXO:8650 ! CC: condensed nuclear chromosome outer kinetochore | BP: establishment of meiotic sister chromatid cohesion | MF: [Term] id: NeXO:7942 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.08081394211811 density:0.8 bootstrap:0.831327229 cc_score:0.0 bp_score:0.0198688 mf_score:0.0 relationship: child_of NeXO:8826 ! CC: | BP: | MF: [Term] id: NeXO:7943 name: CC: HOPS complex | BP: regulation of SNARE complex assembly | MF: def: "CC_def: A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p. | BP_def: Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.13083788818564 density:1 bootstrap:0.84254308 cc_score:0.730183 bp_score:0.572001 mf_score:0.0 relationship: child_of NeXO:9297 ! CC: CORVET complex | BP: regulation of vesicle fusion | MF: relationship: linked_to NeXO:9512 ! CC: | BP: vacuole inheritance | MF: [Term] id: NeXO:9199 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.42605971009232 density:1 bootstrap:0.336974678 cc_score:0.0 bp_score:0.0391188 mf_score:0.0 relationship: child_of NeXO:9352 ! CC: nuclear origin of replication recognition complex | BP: pre-replicative complex assembly | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:8554 ! CC: MCM complex | BP: | MF: relationship: linked_to NeXO:9549 ! CC: replication fork protection complex | BP: replication fork protection | MF: [Term] id: NeXO:9198 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.5693982392322 density:0.0454545454545455 bootstrap:0.328983571 cc_score:0.0 bp_score:0.0100647 mf_score:0.0 relationship: child_of NeXO:9743 ! CC: | BP: | MF: [Term] id: NeXO:7948 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.59999173759442 density:0.833333333333333 bootstrap:0.74544485 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8543 ! CC: | BP: | MF: [Term] id: NeXO:7949 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.399870462 cc_score:0.0 bp_score:0.054019 mf_score:0.0 relationship: child_of NeXO:8963 ! CC: | BP: | MF: [Term] id: NeXO:7238 name: CC: | BP: strand invasion | MF: def: "CC_def: | BP_def: The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70991872644463 density:0.166666666666667 bootstrap:0.688081983 cc_score:0.0 bp_score:0.162617 mf_score:0.0 relationship: child_of NeXO:7903 ! CC: | BP: | MF: [Term] id: NeXO:7239 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33443874600532 density:1 bootstrap:0.90299805 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9024 ! CC: | BP: actin cytoskeleton reorganization | MF: relationship: linked_to NeXO:9373 ! CC: | BP: positive regulation of actin filament bundle assembly | MF: relationship: linked_to NeXO:6785 ! CC: | BP: | MF: relationship: linked_to NeXO:8979 ! CC: | BP: ultradian rhythm | MF: [Term] id: NeXO:8998 name: CC: transcriptional repressor complex | BP: GO:0035955 | MF: def: "CC_def: A protein complex that possesses activity that prevents or downregulates transcription. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90596628923312 density:1 bootstrap:0.601938715 cc_score:0.459179 bp_score:0.587116 mf_score:0.0 relationship: child_of NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:7170 ! CC: | BP: GO:0061393 | MF:mitogen-activated protein kinase binding relationship: linked_to NeXO:9624 ! CC: | BP: negative regulation of transcription during meiosis | MF: [Term] id: NeXO:8999 name: CC: | BP: negative regulation of histone H3-K9 acetylation | MF:histone methyltransferase activity (H3-K36 specific) def: "CC_def: | BP_def: Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:3.80857459149098 density:0.5 bootstrap:0.58830595 cc_score:0.0 bp_score:0.16791 mf_score:0.214926 relationship: child_of NeXO:9750 ! CC: | BP: negative regulation of meiosis | MF: relationship: linked_to NeXO:9630 ! CC: Swr1 complex | BP: histone exchange | MF: [Term] id: NeXO:8992 name: CC: | BP: negative regulation of sequence-specific DNA binding transcription factor activity | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.71513191456891 density:1 bootstrap:0.762336401 cc_score:0.0 bp_score:0.126664 mf_score:0.0 relationship: child_of NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity relationship: linked_to NeXO:7570 ! CC: | BP: protein delipidation | MF: relationship: linked_to NeXO:9351 ! CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity relationship: linked_to NeXO:8594 ! CC: | BP: regulation of invasive growth in response to glucose limitation | MF: relationship: linked_to NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: [Term] id: NeXO:8993 name: CC: | BP: nuclear polyadenylation-dependent snoRNA catabolic process | MF:adenylyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. | MF_def:Catalysis of the transfer of an adenylyl group to an acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:3.91202618974665 density:0.266666666666667 bootstrap:0.316112046 cc_score:0.0 bp_score:0.257743 mf_score:0.156831 relationship: child_of NeXO:9617 ! CC: | BP: nuclear polyadenylation-dependent rRNA catabolic process | MF: [Term] id: NeXO:8991 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.64345816320506 density:0.0916666666666667 bootstrap:0.415638299 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9436 ! CC: peroxisomal membrane | BP: protein targeting to peroxisome | MF: [Term] id: NeXO:8996 name: CC: | BP: | MF:copper ion binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with copper (Cu) ions." [NeXO-GO:term] namespace: NeXO comment: robustness:1.28650622447156 density:0.0606060606060606 bootstrap:0.153665793 cc_score:0.0 bp_score:0.0710513 mf_score:0.105566 relationship: child_of NeXO:9391 ! CC: | BP: | MF: [Term] id: NeXO:8994 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.13651379887464 density:1 bootstrap:0.94507687 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9574 ! CC: mitochondrial small ribosomal subunit | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: relationship: linked_to NeXO:6643 ! CC: | BP: | MF: relationship: linked_to NeXO:7310 ! CC: | BP: | MF: relationship: linked_to NeXO:7692 ! CC: | BP: | MF: [Term] id: NeXO:8995 name: CC: | BP: ribose phosphate metabolic process | MF:nucleotide biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. | MF_def:The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [NeXO-GO:term] namespace: NeXO comment: robustness:6.96879636635273 density:0.285714285714286 bootstrap:0.46246328 cc_score:0.0 bp_score:0.193944 mf_score:0.131511 relationship: child_of NeXO:9579 ! CC: | BP: pentose biosynthetic process | MF: [Term] id: NeXO:9515 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.765258088767161 density:0.0181818181818182 bootstrap:0.279979273 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9815 ! CC: | BP: | MF: [Term] id: NeXO:9514 name: CC: | BP: | MF:dolichyl-phosphate beta-glucosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:8.72871399447878 density:0.75 bootstrap:0.675603827 cc_score:0.0 bp_score:0.0 mf_score:0.100515 relationship: child_of NeXO:9796 ! CC: | BP: protein N-linked glycosylation | MF:transferase activity, transferring hexosyl groups relationship: linked_to NeXO:9296 ! CC: | BP: | MF: relationship: linked_to NeXO:8759 ! CC: | BP: | MF: relationship: linked_to NeXO:9527 ! CC: | BP: | MF: relationship: linked_to NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:9710 ! CC: | BP: oligosaccharide biosynthetic process | MF: [Term] id: NeXO:9516 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.00075618015985 density:0.380952380952381 bootstrap:0.443561017 cc_score:0.0 bp_score:0.0705886 mf_score:0.0917887 relationship: child_of NeXO:9815 ! CC: | BP: | MF: [Term] id: NeXO:6239 name: CC: | BP: peptidyl-lysine monomethylation | MF: def: "CC_def: | BP_def: The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25953013794886 density:1 bootstrap:0.845976158 cc_score:0.0 bp_score:0.179727 mf_score:0.0551117 relationship: child_of NeXO:6709 ! CC: | BP: | MF: [Term] id: NeXO:6238 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.657222599 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7140 ! CC: | BP: | MF:3-dehydrosphinganine reductase activity [Term] id: NeXO:9513 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.01987257934951 density:0.0611664295874822 bootstrap:0.158359246 cc_score:0.0 bp_score:0.0187066 mf_score:0.0 relationship: child_of NeXO:9785 ! CC: | BP: | MF: [Term] id: NeXO:9512 name: CC: | BP: vacuole inheritance | MF: def: "CC_def: | BP_def: The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.86594446190876 density:0.666666666666667 bootstrap:0.634272289 cc_score:0.0 bp_score:0.179939 mf_score:0.0 relationship: child_of NeXO:9735 ! CC: endosomal part | BP: regulation of vacuole fusion, non-autophagic | MF: [Term] id: NeXO:6235 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.5343643091394 density:0.333333333333333 bootstrap:0.476689999 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6236 ! CC: | BP: | MF: [Term] id: NeXO:6234 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.421614319 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6235 ! CC: | BP: | MF: [Term] id: NeXO:6237 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.474458269 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6601 ! CC: | BP: | MF:malate synthase activity relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: [Term] id: NeXO:6236 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75820221120187 density:0.0444444444444444 bootstrap:0.5898562 cc_score:0.0 bp_score:0.0803839 mf_score:0.0 relationship: child_of NeXO:6833 ! CC: | BP: | MF: [Term] id: NeXO:9519 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.32750767826834 density:1 bootstrap:0.66340135 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9787 ! CC: | BP: | MF: relationship: linked_to NeXO:9503 ! CC: | BP: | MF: relationship: linked_to NeXO:9321 ! CC: | BP: | MF: relationship: linked_to NeXO:9506 ! CC: | BP: | MF: relationship: linked_to NeXO:9539 ! CC: | BP: | MF: [Term] id: NeXO:9518 name: CC: eukaryotic translation initiation factor 3 complex | BP: translation reinitiation | MF: def: "CC_def: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. | BP_def: A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.77350054961436 density:0.928571428571429 bootstrap:0.400204897 cc_score:0.383195 bp_score:0.305638 mf_score:0.0 relationship: child_of NeXO:9740 ! CC: | BP: translational initiation | MF:translation initiation factor activity [Term] id: NeXO:6233 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.596065407 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6908 ! CC: | BP: | MF: [Term] id: NeXO:6232 name: CC: | BP: late endosome to Golgi transport | MF:magnesium-dependent protein serine/threonine phosphatase activity def: "CC_def: | BP_def: The directed movement of substances from late endosomes to the Golgi. | MF_def:Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70554073 cc_score:0.0 bp_score:0.438558 mf_score:0.220331 relationship: child_of NeXO:6834 ! CC: | BP: | MF: [Term] id: NeXO:7899 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.46173349406268 density:0.380952380952381 bootstrap:0.332090507 cc_score:0.0 bp_score:0.0 mf_score:0.0717698 relationship: child_of NeXO:8804 ! CC: | BP: iron assimilation by chelation and transport | MF: [Term] id: NeXO:7926 name: CC: | BP: | MF:ligase activity, forming carbon-sulfur bonds def: "CC_def: | BP_def: | MF_def:Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33441638343865 density:0.115384615384615 bootstrap:0.190971426 cc_score:0.0 bp_score:0.0424787 mf_score:0.160991 relationship: child_of NeXO:8449 ! CC: lipid particle | BP: | MF: [Term] id: NeXO:8696 name: CC: | BP: | MF:ATPase activity, uncoupled def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [NeXO-GO:term] namespace: NeXO comment: robustness:1.92329135352896 density:1 bootstrap:0.61293159 cc_score:0.0 bp_score:0.0 mf_score:0.437706 relationship: child_of NeXO:9191 ! CC: | BP: | MF: [Term] id: NeXO:5436 name: CC: | BP: | MF:alcohol transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [NeXO-GO:term] namespace: NeXO comment: robustness:2.06155919453145 density:0.333333333333333 bootstrap:0.86053925 cc_score:0.0 bp_score:0.0880566 mf_score:0.149556 relationship: child_of NeXO:6383 ! CC: | BP: | MF:glucan exo-1,3-beta-glucosidase activity [Term] id: NeXO:9478 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82712148983113 density:0.0248015873015873 bootstrap:0.195172828 cc_score:0.0 bp_score:0.0525152 mf_score:0.0584167 relationship: child_of NeXO:9861 ! CC: | BP: | MF: [Term] id: NeXO:8111 name: CC: | BP: nitrogen catabolite regulation of transcription | MF:gamma-aminobutyric acid:hydrogen symporter activity def: "CC_def: | BP_def: A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:6.48184614682398 density:0.5 bootstrap:0.62691847 cc_score:0.0 bp_score:0.260745 mf_score:0.126052 relationship: child_of NeXO:8879 ! CC: | BP: response to organic nitrogen | MF: [Term] id: NeXO:9025 name: CC: | BP: mRNA splice site selection | MF:U1 snRNA binding def: "CC_def: | BP_def: Selection of a splice site by components of the assembling spliceosome. | MF_def:Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [NeXO-GO:term] namespace: NeXO comment: robustness:4.64559777852364 density:1 bootstrap:0.59600208 cc_score:0.0 bp_score:0.154764 mf_score:0.442823 relationship: child_of NeXO:9179 ! CC: | BP: | MF: relationship: linked_to NeXO:9616 ! CC: | BP: regulation of transcription termination, DNA-dependent | MF: relationship: linked_to NeXO:7991 ! CC: | BP: | MF: relationship: linked_to NeXO:8744 ! CC: | BP: | MF: [Term] id: NeXO:9779 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.8500501783485 density:0.590643274853801 bootstrap:0.571333432 cc_score:0.0 bp_score:0.0237816 mf_score:0.0 relationship: child_of NeXO:9949 ! CC: | BP: | MF: [Term] id: NeXO:9778 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.555697439470402 density:0.0277777777777778 bootstrap:0.123860823 cc_score:0.012007 bp_score:0.0566724 mf_score:0.0 relationship: child_of NeXO:9875 ! CC: UTP-C complex | BP: transcription elongation from RNA polymerase I promoter | MF:RNA polymerase II core binding [Term] id: NeXO:7000 name: CC: | BP: fumarate transport | MF:phosphoenolpyruvate carboxykinase (ATP) activity def: "CC_def: | BP_def: The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.84341549056453 density:0.666666666666667 bootstrap:0.73680674 cc_score:0.0 bp_score:0.270493 mf_score:0.269822 relationship: child_of NeXO:7576 ! CC: | BP: | MF:succinate dehydrogenase activity [Term] id: NeXO:9774 name: CC: | BP: regulation of protein desumoylation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.16373084023832 density:0.866666666666667 bootstrap:0.514733405 cc_score:0.0 bp_score:0.340896 mf_score:0.0 relationship: child_of NeXO:9912 ! CC: | BP: protein desumoylation | MF: relationship: linked_to NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: [Term] id: NeXO:9777 name: CC: Sin3-type complex | BP: regulation of chromatin silencing at rDNA | MF: def: "CC_def: Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. | BP_def: Any process that modulates the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.25960483991253 density:0.373684210526316 bootstrap:0.222872631 cc_score:0.365525 bp_score:0.309344 mf_score:0.0512294 relationship: child_of NeXO:9881 ! CC: Rpd3L-Expanded complex | BP: negative regulation of chromatin silencing at telomere | MF:histone deacetylation [Term] id: NeXO:9776 name: CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter def: "CC_def: A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. | BP_def: Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. | MF_def:Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:7.69032076401637 density:1 bootstrap:0.65328488 cc_score:0.583633 bp_score:0.399311 mf_score:0.362853 relationship: child_of NeXO:9859 ! CC: transcription elongation factor complex | BP: regulation of histone ubiquitination | MF: [Term] id: NeXO:9771 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.25070138742695 density:0.0274038461538462 bootstrap:0.199686305 cc_score:0.0 bp_score:0.0929222 mf_score:0.0320759 relationship: child_of NeXO:9922 ! CC: | BP: | MF: [Term] id: NeXO:9027 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.5238169947209 density:0.964285714285714 bootstrap:0.69380858 cc_score:0.0 bp_score:0.0502335 mf_score:0.0 relationship: child_of NeXO:9227 ! CC: CCR4-NOT core complex | BP: nuclear-transcribed mRNA poly(A) tail shortening | MF:poly(A)-specific ribonuclease activity [Term] id: NeXO:9773 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.03365027461024 density:0.025 bootstrap:0.1852247 cc_score:0.0 bp_score:0.0107262 mf_score:0.0 relationship: child_of NeXO:9888 ! CC: | BP: | MF:translational initiation [Term] id: NeXO:9772 name: CC: DNA-directed RNA polymerase II, core complex | BP: | MF:RNA-directed RNA polymerase activity def: "CC_def: RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. | BP_def: | MF_def:Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [NeXO-GO:term] namespace: NeXO comment: robustness:14.6104000370275 density:0.963636363636364 bootstrap:0.682858187 cc_score:0.342602 bp_score:0.0642254 mf_score:0.338588 relationship: child_of NeXO:9972 ! CC: | BP: transcription-coupled nucleotide-excision repair | MF:core RNA polymerase II binding transcription factor activity [Term] id: NeXO:7302 name: CC: | BP: | MF:TFIIH-class transcription factor recruiting transcription factor activity def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [NeXO-GO:term] namespace: NeXO comment: robustness:6.72204225474403 density:1 bootstrap:0.74870971 cc_score:0.0 bp_score:0.0 mf_score:0.179035 relationship: child_of NeXO:7776 ! CC: | BP: | MF:TFIIH-class transcription factor binding [Term] id: NeXO:8867 name: CC: | BP: GO:0035961 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81832100168128 density:1 bootstrap:0.547851628 cc_score:0.0 bp_score:0.294849 mf_score:0.0 relationship: child_of NeXO:9327 ! CC: | BP: positive regulation of lipid biosynthetic process | MF: relationship: linked_to NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:6097 ! CC: | BP: | MF: [Term] id: NeXO:7300 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.30828605848281 density:0.166666666666667 bootstrap:0.402804836 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8031 ! CC: | BP: | MF: [Term] id: NeXO:7301 name: CC: | BP: GO:0035948 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62306624734001 density:1 bootstrap:0.72502124 cc_score:0.0 bp_score:0.177286 mf_score:0.0 relationship: child_of NeXO:7608 ! CC: | BP: | MF: [Term] id: NeXO:9289 name: CC: | BP: | MF:AMP deaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: AMP + H2O = IMP + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:2.62979054700107 density:1 bootstrap:0.38197989 cc_score:0.0 bp_score:0.022529 mf_score:0.293905 relationship: child_of NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:9268 ! CC: | BP: | MF: relationship: linked_to NeXO:9327 ! CC: | BP: positive regulation of lipid biosynthetic process | MF: [Term] id: NeXO:7307 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.768807429 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7308 ! CC: | BP: regulation of mitotic spindle elongation | MF: [Term] id: NeXO:8860 name: CC: | BP: protein sumoylation | MF: def: "CC_def: | BP_def: The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03026591471881 density:0.107142857142857 bootstrap:0.409918524 cc_score:0.0 bp_score:0.295083 mf_score:0.0 relationship: child_of NeXO:9806 ! CC: | BP: | MF: [Term] id: NeXO:7305 name: CC: | BP: | MF:FAD transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of or within a cell, or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [NeXO-GO:term] namespace: NeXO comment: robustness:1.98553003071775 density:0.333333333333333 bootstrap:0.79823724 cc_score:0.0 bp_score:0.0 mf_score:0.1354 relationship: child_of NeXO:8583 ! CC: | BP: | MF: [Term] id: NeXO:9285 name: CC: | BP: cell shape checkpoint | MF:protein phosphatase type 2A regulator activity def: "CC_def: | BP_def: A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular shaping and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective. | MF_def:Modulation of the activity of the enzyme protein phosphatase type 2A." [NeXO-GO:term] namespace: NeXO comment: robustness:2.3391603844152 density:0.5 bootstrap:0.362007669 cc_score:0.0 bp_score:0.248404 mf_score:0.411612 relationship: child_of NeXO:9640 ! CC: protein phosphatase type 2A complex | BP: mitotic cell cycle checkpoint | MF: [Term] id: NeXO:9021 name: CC: | BP: positive regulation of sister chromatid cohesion | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.37598611577027 density:0.638888888888889 bootstrap:0.59818814 cc_score:0.0 bp_score:0.117287 mf_score:0.0 relationship: child_of NeXO:9601 ! CC: | BP: | MF: [Term] id: NeXO:7308 name: CC: | BP: regulation of mitotic spindle elongation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.468934664 cc_score:0.0 bp_score:0.316464 mf_score:0.0 relationship: child_of NeXO:8443 ! CC: | BP: fermentation | MF: [Term] id: NeXO:9286 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.33031202208468 density:0.333333333333333 bootstrap:0.358332415 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9483 ! CC: | BP: | MF: relationship: linked_to NeXO:9224 ! CC: | BP: | MF: [Term] id: NeXO:9281 name: CC: mitochondrial respiratory chain | BP: mitochondrial ATP synthesis coupled electron transport | MF:ubiquinol-cytochrome-c reductase activity def: "CC_def: The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. | BP_def: The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [NeXO-GO:term] namespace: NeXO comment: robustness:21.757574216883 density:0.673684210526316 bootstrap:0.7219694 cc_score:0.186736 bp_score:0.159007 mf_score:0.127162 relationship: child_of NeXO:9423 ! CC: respiratory chain | BP: respiratory electron transport chain | MF: [Term] id: NeXO:9283 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.482616207496692 density:0.00790513833992095 bootstrap:0.111395215 cc_score:0.0 bp_score:0.0119134 mf_score:0.0 relationship: child_of NeXO:9704 ! CC: | BP: | MF: [Term] id: NeXO:9282 name: CC: Set3 complex | BP: positive regulation of stress-activated MAPK cascade | MF:NAD-independent histone deacetylase activity def: "CC_def: A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p. | BP_def: Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. | MF_def:Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [NeXO-GO:term] namespace: NeXO comment: robustness:7.6237705631991 density:1 bootstrap:0.64202706 cc_score:0.550112 bp_score:0.443182 mf_score:0.127231 relationship: child_of NeXO:9750 ! CC: | BP: negative regulation of meiosis | MF: [Term] id: NeXO:7007 name: CC: protein phosphatase type 1 complex | BP: | MF:protein phosphatase 1 binding def: "CC_def: A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. | BP_def: | MF_def:Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [NeXO-GO:term] namespace: NeXO comment: robustness:2.10296950207298 density:1 bootstrap:0.73280394 cc_score:0.253197 bp_score:0.0 mf_score:0.182605 relationship: child_of NeXO:7047 ! CC: | BP: gene conversion at mating-type locus, DNA double-strand break formation | MF: [Term] id: NeXO:9022 name: CC: | BP: | MF:GDP-dissociation inhibitor activity def: "CC_def: | BP_def: | MF_def:Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96655076431881 density:1 bootstrap:0.640814264 cc_score:0.0 bp_score:0.0190042 mf_score:0.150978 relationship: child_of NeXO:9255 ! CC: | BP: | MF: relationship: linked_to NeXO:9533 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: [Term] id: NeXO:6404 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7517006 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7040 ! CC: | BP: | MF:pyridoxine:NADP 4-dehydrogenase activity [Term] id: NeXO:9490 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.7468852452458 density:0.273333333333333 bootstrap:0.58598012 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9828 ! CC: organelle inner membrane | BP: establishment of protein localization in mitochondrion | MF:channel activity [Term] id: NeXO:7045 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.96462386672756 density:0.666666666666667 bootstrap:0.733262674 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8161 ! CC: | BP: | MF: relationship: linked_to NeXO:9067 ! CC: | BP: | MF: [Term] id: NeXO:7044 name: CC: | BP: xylulose metabolic process | MF:D-xylulose reductase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. | MF_def:Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:2.47972684542504 density:0.333333333333333 bootstrap:0.65636072 cc_score:0.0 bp_score:0.338133 mf_score:0.18527 relationship: child_of NeXO:7213 ! CC: | BP: D-xylose metabolic process | MF:sugar-phosphatase activity [Term] id: NeXO:7047 name: CC: | BP: gene conversion at mating-type locus, DNA double-strand break formation | MF: def: "CC_def: | BP_def: The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79813427245737 density:0.333333333333333 bootstrap:0.6546713 cc_score:0.0 bp_score:0.313991 mf_score:0.0 relationship: child_of NeXO:7909 ! CC: | BP: regulation of phosphoprotein phosphatase activity | MF:protein phosphatase binding [Term] id: NeXO:7046 name: CC: m-AAA complex | BP: | MF: def: "CC_def: Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.36378194155497 density:0.333333333333333 bootstrap:0.376590132 cc_score:0.23081 bp_score:0.0132371 mf_score:0.0 relationship: child_of NeXO:7817 ! CC: | BP: | MF: [Term] id: NeXO:7041 name: CC: DNA ligase IV complex | BP: | MF: def: "CC_def: A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.23345799787017 density:0.333333333333333 bootstrap:0.308054669 cc_score:0.181478 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7912 ! CC: | BP: | MF: [Term] id: NeXO:7040 name: CC: | BP: | MF:pyridoxine:NADP 4-dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [NeXO-GO:term] namespace: NeXO comment: robustness:2.5488057645633 density:0.666666666666667 bootstrap:0.59203369 cc_score:0.0 bp_score:0.0 mf_score:0.315467 relationship: child_of NeXO:7080 ! CC: | BP: | MF: [Term] id: NeXO:5467 name: CC: nuclear telomere cap complex | BP: negative regulation of telomere maintenance | MF:single-stranded telomeric DNA binding def: "CC_def: A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. | MF_def:Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.96004935284376 density:0.666666666666667 bootstrap:0.798492505 cc_score:0.153923 bp_score:0.273414 mf_score:0.193502 relationship: child_of NeXO:5479 ! CC: | BP: telomere maintenance via telomerase | MF:ATP-dependent DNA/RNA helicase activity [Term] id: NeXO:7042 name: CC: | BP: fatty acid elongation | MF:fatty acid elongase activity def: "CC_def: | BP_def: The elongation of a fatty acid chain by the sequential addition of two-carbon units. | MF_def:Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.94995989488263 density:0.5 bootstrap:0.57574476 cc_score:0.0 bp_score:0.490887 mf_score:0.616675 relationship: child_of NeXO:7043 ! CC: | BP: sphingolipid biosynthetic process | MF: [Term] id: NeXO:5469 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.563054469 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5706 ! CC: | BP: | MF: [Term] id: NeXO:5468 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79948463 cc_score:0.0 bp_score:0.0 mf_score:0.0312994 relationship: child_of NeXO:6541 ! CC: | BP: | MF: [Term] id: NeXO:7049 name: CC: | BP: 1,6-beta-glucan metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.20107744645347 density:0.222222222222222 bootstrap:0.329320362 cc_score:0.0 bp_score:0.16629 mf_score:0.0 relationship: child_of NeXO:7682 ! CC: | BP: beta-glucan biosynthetic process | MF: [Term] id: NeXO:7048 name: CC: | BP: 1,6-beta-glucan biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of beta-1,6 glucans. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56569277788205 density:0.5 bootstrap:0.84117356 cc_score:0.0 bp_score:0.277473 mf_score:0.0609752 relationship: child_of NeXO:7049 ! CC: | BP: 1,6-beta-glucan metabolic process | MF: [Term] id: NeXO:5267 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89735088 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6467 ! CC: | BP: cytochrome complex assembly | MF: [Term] id: NeXO:5266 name: CC: | BP: | MF:RNA lariat debranching enzyme activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35409380186311 density:1 bootstrap:0.91826784 cc_score:0.0 bp_score:0.0 mf_score:0.438715 relationship: child_of NeXO:6451 ! CC: | BP: | MF: [Term] id: NeXO:5265 name: CC: carbamoyl-phosphate synthase complex | BP: asparaginyl-tRNA aminoacylation | MF:asparagine-tRNA ligase activity def: "CC_def: A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events. | BP_def: The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83534914 cc_score:0.291709 bp_score:0.282874 mf_score:0.29282 relationship: child_of NeXO:6024 ! CC: | BP: | MF: [Term] id: NeXO:5264 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87642303 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5756 ! CC: | BP: | MF: [Term] id: NeXO:5263 name: CC: | BP: methylglyoxal catabolic process to D-lactate | MF:lactoylglutathione lyase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. | MF_def:Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.883048448 cc_score:0.0 bp_score:0.221979 mf_score:0.441633 relationship: child_of NeXO:5431 ! CC: | BP: D-xylose catabolic process | MF:glucose 1-dehydrogenase (NADP+) activity [Term] id: NeXO:5262 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90057709 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6011 ! CC: | BP: | MF: [Term] id: NeXO:5261 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25056811525033 density:1 bootstrap:0.83927864 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5784 ! CC: | BP: | MF: [Term] id: NeXO:9491 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.50809934058076 density:0.111111111111111 bootstrap:0.43658025 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9648 ! CC: | BP: | MF: [Term] id: NeXO:5269 name: CC: | BP: | MF:endochitinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.875862112 cc_score:0.0 bp_score:0.0 mf_score:0.451503 relationship: child_of NeXO:5811 ! CC: | BP: | MF:cellulase activity [Term] id: NeXO:5268 name: CC: | BP: | MF:epoxide hydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: an epoxide + H2O = a glycol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87430513 cc_score:0.0 bp_score:0.0877434 mf_score:0.302589 relationship: child_of NeXO:5795 ! CC: | BP: | MF:hydrolase activity, acting on ether bonds [Term] id: NeXO:6405 name: CC: | BP: proline catabolic process to glutamate | MF:proline dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. | MF_def:Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:4.73180955660468 density:0.4 bootstrap:0.80798727 cc_score:0.0 bp_score:0.438953 mf_score:0.160709 relationship: child_of NeXO:7579 ! CC: | BP: pyrimidine base biosynthetic process | MF: [Term] id: NeXO:7972 name: CC: | BP: protein exit from endoplasmic reticulum | MF: def: "CC_def: | BP_def: The directed movement of proteins from the endoplasmic reticulum. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27532463931011 density:1 bootstrap:0.85784453 cc_score:0.0 bp_score:0.145997 mf_score:0.0 relationship: child_of NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:5737 ! CC: | BP: isopropylmalate transport | MF:isopropylmalate transmembrane transporter activity [Term] id: NeXO:8608 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64038780722426 density:0.3 bootstrap:0.522995833 cc_score:0.0 bp_score:0.0662929 mf_score:0.0 relationship: child_of NeXO:9148 ! CC: | BP: spindle pole body duplication in nuclear envelope | MF: [Term] id: NeXO:7039 name: CC: | BP: low-affinity iron ion transport | MF:copper ion transmembrane transporter activity def: "CC_def: | BP_def: The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations. | MF_def:Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.52489612445649 density:0.666666666666667 bootstrap:0.58097838 cc_score:0.0 bp_score:0.319055 mf_score:0.243922 relationship: child_of NeXO:7683 ! CC: | BP: | MF: [Term] id: NeXO:6989 name: CC: | BP: | MF:sequence-specific DNA binding transcription factor recruiting transcription factor activity def: "CC_def: | BP_def: | MF_def:The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [NeXO-GO:term] namespace: NeXO comment: robustness:1.59436431064021 density:0.166666666666667 bootstrap:0.598224751 cc_score:0.0 bp_score:0.0 mf_score:0.114125 relationship: child_of NeXO:6992 ! CC: | BP: regulation of sulfur metabolic process | MF: [Term] id: NeXO:6988 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.31762347619763 density:1 bootstrap:0.287676572 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7312 ! CC: | BP: | MF: [Term] id: NeXO:6987 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.55200995696853 density:1 bootstrap:0.51075363 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7539 ! CC: | BP: | MF: [Term] id: NeXO:6986 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94022377147722 density:1 bootstrap:0.8575115 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7769 ! CC: | BP: proton-transporting two-sector ATPase complex assembly | MF: relationship: linked_to NeXO:7541 ! CC: proton-transporting two-sector ATPase complex, catalytic domain | BP: | MF: [Term] id: NeXO:6985 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.01959241882134 density:0.666666666666667 bootstrap:0.83093986 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8437 ! CC: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | BP: proton-transporting ATPase activity, rotational mechanism | MF:proton-transporting ATPase activity, rotational mechanism relationship: linked_to NeXO:8573 ! CC: mitochondrial respiratory chain complex IV | BP: mitochondrial electron transport, cytochrome c to oxygen | MF:cytochrome-c oxidase activity [Term] id: NeXO:8601 name: CC: | BP: mannose transport | MF:glucose binding def: "CC_def: | BP_def: The directed movement of mannose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. | MF_def:Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:6.92817860279538 density:1 bootstrap:0.79533325 cc_score:0.0 bp_score:0.376035 mf_score:0.29838 relationship: child_of NeXO:8937 ! CC: | BP: hexose transport | MF:glucose transport [Term] id: NeXO:8606 name: CC: Mre11 complex | BP: single-stranded telomeric DNA binding | MF:G-quadruplex DNA binding def: "CC_def: Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. | BP_def: Interacting selectively and non-covalently with single-stranded telomere-associated DNA. | MF_def:Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [NeXO-GO:term] namespace: NeXO comment: robustness:3.73564110375741 density:1 bootstrap:0.770776509 cc_score:0.875283 bp_score:0.328125 mf_score:0.87865 relationship: child_of NeXO:9589 ! CC: | BP: non-recombinational repair | MF:double-stranded telomeric DNA binding relationship: linked_to NeXO:8152 ! CC: Cul8-RING ubiquitin ligase complex | BP: replication fork processing | MF:H3 histone acetyltransferase activity relationship: linked_to NeXO:8556 ! CC: | BP: | MF: relationship: linked_to NeXO:8496 ! CC: | BP: | MF: relationship: linked_to NeXO:8709 ! CC: Rhp55-Rhp57 complex | BP: double-strand break repair via synthesis-dependent strand annealing | MF:protein heterodimerization activity relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity [Term] id: NeXO:8607 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.01802954961092 density:0.333333333333333 bootstrap:0.297552908 cc_score:0.0 bp_score:0.0248008 mf_score:0.0 relationship: child_of NeXO:9075 ! CC: microtubule organizing center part | BP: | MF: [Term] id: NeXO:8604 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.27508451318387 density:0.666666666666667 bootstrap:0.500380779 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8950 ! CC: | BP: | MF:profilin binding [Term] id: NeXO:6980 name: CC: | BP: inactivation of MAPK activity | MF: def: "CC_def: | BP_def: Any process that terminates the activity of the active enzyme MAP kinase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90902336746601 density:0.333333333333333 bootstrap:0.73790687 cc_score:0.0 bp_score:0.177207 mf_score:0.0270968 relationship: child_of NeXO:7092 ! CC: | BP: regulation of MAP kinase activity | MF: [Term] id: NeXO:9039 name: CC: nuclear cap binding complex | BP: | MF:RNA cap binding def: "CC_def: A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. | BP_def: | MF_def:Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33750586547842 density:1 bootstrap:0.90537243 cc_score:0.88327 bp_score:0.0 mf_score:0.292059 relationship: child_of NeXO:9799 ! CC: RNA cap binding complex | BP: | MF: relationship: linked_to NeXO:6854 ! CC: | BP: | MF: relationship: linked_to NeXO:9087 ! CC: | BP: | MF: relationship: linked_to NeXO:8756 ! CC: eukaryotic translation initiation factor 4F complex | BP: stress granule assembly | MF: relationship: linked_to NeXO:8393 ! CC: | BP: | MF: relationship: linked_to NeXO:7517 ! CC: | BP: nuclear mRNA 5'-splice site recognition | MF: relationship: linked_to NeXO:9551 ! CC: | BP: | MF: relationship: linked_to NeXO:9177 ! CC: RES complex | BP: snRNA capping | MF: [Term] id: NeXO:8959 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.42414007058287 density:0.666666666666667 bootstrap:0.535535618 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9095 ! CC: | BP: regulation of transcription from RNA polymerase II promoter by pheromones | MF: [Term] id: NeXO:8738 name: CC: | BP: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.5002280379955 density:0.536764705882353 bootstrap:0.378332776 cc_score:0.0 bp_score:0.168595 mf_score:0.0 relationship: child_of NeXO:8874 ! CC: | BP: late endosome to vacuole transport | MF: [Term] id: NeXO:8739 name: CC: | BP: | MF:diphosphoinositol-pentakisphosphate kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.382508814 cc_score:0.0 bp_score:0.0805125 mf_score:0.314942 relationship: child_of NeXO:9203 ! CC: | BP: | MF:inositol hexakisphosphate 4-kinase activity relationship: linked_to NeXO:7303 ! CC: | BP: | MF: [Term] id: NeXO:8737 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35926616877116 density:1 bootstrap:0.623285483 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9173 ! CC: | BP: | MF: relationship: linked_to NeXO:6523 ! CC: | BP: late endosome to vacuole transport via multivesicular body sorting pathway | MF: [Term] id: NeXO:8734 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.15952265147866 density:0.821428571428571 bootstrap:0.658894824 cc_score:0.0 bp_score:0.0 mf_score:0.0387649 relationship: child_of NeXO:9491 ! CC: | BP: | MF: [Term] id: NeXO:8735 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.02031224611637 density:0.307692307692308 bootstrap:0.557537264 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9269 ! CC: | BP: | MF: [Term] id: NeXO:8732 name: CC: | BP: response to hydroperoxide | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.12408302687056 density:1 bootstrap:0.72509829 cc_score:0.0 bp_score:0.219381 mf_score:0.0 relationship: child_of NeXO:9467 ! CC: | BP: DNA replication, removal of RNA primer | MF: relationship: linked_to NeXO:7086 ! CC: | BP: | MF: [Term] id: NeXO:8733 name: CC: | BP: | MF:calcium channel activity def: "CC_def: | BP_def: | MF_def:Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:1.06784696554283 density:0.133333333333333 bootstrap:0.15333105 cc_score:0.0 bp_score:0.0 mf_score:0.101579 relationship: child_of NeXO:9468 ! CC: CCR4-NOT complex | BP: | MF: [Term] id: NeXO:8730 name: CC: | BP: positive regulation of lipid catabolic process | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70913360932543 density:0.2 bootstrap:0.352958055 cc_score:0.0 bp_score:0.229851 mf_score:0.0 relationship: child_of NeXO:9263 ! CC: | BP: fatty acid oxidation | MF: [Term] id: NeXO:8731 name: CC: | BP: cortical protein anchoring | MF:SAM domain binding def: "CC_def: | BP_def: A process in which a protein or protein complex is maintained in a specific location in the cell cortex. | MF_def:Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [NeXO-GO:term] namespace: NeXO comment: robustness:2.36605100240001 density:0.666666666666667 bootstrap:0.510177315 cc_score:0.0 bp_score:0.20196 mf_score:0.236127 relationship: child_of NeXO:9341 ! CC: heterotrimeric G-protein complex | BP: osmosensory signaling pathway via Sho1 osmosensor | MF:protein domain specific binding [Term] id: NeXO:8516 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17973911127028 density:0.107142857142857 bootstrap:0.472498823 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9410 ! CC: | BP: | MF: [Term] id: NeXO:8041 name: CC: MutLalpha complex | BP: meiotic heteroduplex formation | MF:dinucleotide insertion or deletion binding def: "CC_def: A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. | BP_def: During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. | MF_def:Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [NeXO-GO:term] namespace: NeXO comment: robustness:2.96028298099938 density:1 bootstrap:0.484021481 cc_score:0.450727 bp_score:0.293128 mf_score:0.457903 relationship: child_of NeXO:8266 ! CC: MutLbeta complex | BP: chiasma assembly | MF:DNA insertion or deletion binding [Term] id: NeXO:8514 name: CC: | BP: trehalose transport | MF:trehalose transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. | MF_def:Catalysis of the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.631644424 cc_score:0.0 bp_score:0.445159 mf_score:0.44389 relationship: child_of NeXO:8886 ! CC: | BP: maltose transport | MF:maltose:hydrogen symporter activity relationship: linked_to NeXO:8865 ! CC: | BP: | MF: [Term] id: NeXO:8515 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.90638133201814 density:1 bootstrap:0.398872034 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8734 ! CC: | BP: | MF: relationship: linked_to NeXO:6736 ! CC: | BP: | MF: [Term] id: NeXO:8512 name: CC: | BP: barrier septum formation involved in cell cycle cytokinesis | MF: def: "CC_def: | BP_def: A barrier septum formation process that occurs during, and contributes to, cytokinesis that occurs in the context of cell cycle progression. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.706018479 cc_score:0.0 bp_score:0.221551 mf_score:0.0 relationship: child_of NeXO:9229 ! CC: 1,3-beta-D-glucan synthase complex | BP: 1,3-beta-D-glucan biosynthetic process | MF:1,3-beta-D-glucan synthase activity [Term] id: NeXO:8045 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.240935146 cc_score:0.0 bp_score:0.0723111 mf_score:0.0 relationship: child_of NeXO:8599 ! CC: | BP: N-terminal protein amino acid modification | MF: [Term] id: NeXO:8046 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.525942349 cc_score:0.0 bp_score:0.0892273 mf_score:0.0 relationship: child_of NeXO:8936 ! CC: | BP: | MF: [Term] id: NeXO:8047 name: CC: | BP: cytokinesis, completion of separation | MF: def: "CC_def: | BP_def: The process of finishing cell separation, which results in two physically separated cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2874873235378 density:1 bootstrap:0.86704021 cc_score:0.0 bp_score:0.164411 mf_score:0.0 relationship: child_of NeXO:9118 ! CC: | BP: microtubule bundle formation | MF: relationship: linked_to NeXO:6781 ! CC: | BP: | MF: relationship: linked_to NeXO:9351 ! CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity [Term] id: NeXO:8048 name: CC: lateral element | BP: meiotic recombination checkpoint | MF:SUMO polymer binding def: "CC_def: A proteinaceous core found between sister chromatids during meiotic prophase. | BP_def: A checkpoint that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes. | MF_def:Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [NeXO-GO:term] namespace: NeXO comment: robustness:5.21321893734996 density:1 bootstrap:0.75054458 cc_score:0.444926 bp_score:0.337175 mf_score:0.224093 relationship: child_of NeXO:8789 ! CC: transverse filament | BP: synaptonemal complex assembly | MF: [Term] id: NeXO:8049 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7479533362275 density:0.0641025641025641 bootstrap:0.227069892 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9031 ! CC: | BP: | MF: [Term] id: NeXO:8519 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.38903971 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9054 ! CC: | BP: tRNA re-export from nucleus | MF: [Term] id: NeXO:5670 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.846721942 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6083 ! CC: | BP: | MF: [Term] id: NeXO:5671 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28811453932124 density:1 bootstrap:0.86751575 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7873 ! CC: | BP: | MF: [Term] id: NeXO:5672 name: CC: | BP: cyclin catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.83021611222643 density:1 bootstrap:0.555042956 cc_score:0.0 bp_score:0.353158 mf_score:0.0 relationship: child_of NeXO:6066 ! CC: | BP: mitotic metaphase/anaphase transition | MF: relationship: linked_to NeXO:5452 ! CC: | BP: activation of mitotic anaphase-promoting complex activity | MF:mitotic anaphase-promoting complex activity relationship: linked_to NeXO:8525 ! CC: | BP: | MF: [Term] id: NeXO:5673 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89671248 cc_score:0.0 bp_score:0.0982116 mf_score:0.0 relationship: child_of NeXO:6449 ! CC: | BP: | MF: [Term] id: NeXO:8282 name: CC: transcription factor TFIIE complex | BP: | MF: def: "CC_def: A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69485663236804 density:0.666666666666667 bootstrap:0.66182668 cc_score:0.568052 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8976 ! CC: | BP: | MF: [Term] id: NeXO:8283 name: CC: | BP: | MF:protein-arginine N-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.683591168 cc_score:0.0 bp_score:0.0 mf_score:0.1345 relationship: child_of NeXO:9093 ! CC: | BP: | MF: [Term] id: NeXO:8280 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17929492137728 density:1 bootstrap:0.786962178 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8892 ! CC: | BP: membrane addition at site of cytokinesis | MF: relationship: linked_to NeXO:9001 ! CC: | BP: activation of Ras GTPase activity | MF: [Term] id: NeXO:5677 name: CC: | BP: | MF:high-affinity tryptophan transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89077249 cc_score:0.0 bp_score:0.0 mf_score:0.452443 relationship: child_of NeXO:6591 ! CC: | BP: | MF: [Term] id: NeXO:5678 name: CC: | BP: tRNA 3'-terminal CCA addition | MF:tRNA adenylyltransferase activity def: "CC_def: | BP_def: Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. | MF_def:Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.785960188 cc_score:0.0 bp_score:0.448888 mf_score:0.440871 relationship: child_of NeXO:6592 ! CC: | BP: valyl-tRNA aminoacylation | MF:valine-tRNA ligase activity [Term] id: NeXO:5679 name: CC: | BP: ADP transport | MF:ADP transport def: "CC_def: | BP_def: The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77639006 cc_score:0.0 bp_score:0.291667 mf_score:0.291667 relationship: child_of NeXO:6005 ! CC: | BP: alanyl-tRNA aminoacylation | MF:alanine-tRNA ligase activity [Term] id: NeXO:8288 name: CC: | BP: extrachromosomal rDNA circle accumulation involved in replicative cell aging | MF:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity def: "CC_def: | BP_def: Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. | MF_def:Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:2.78666266666978 density:0.266666666666667 bootstrap:0.458346128 cc_score:0.0 bp_score:0.139311 mf_score:0.1391 relationship: child_of NeXO:9377 ! CC: | BP: | MF: [Term] id: NeXO:8289 name: CC: | BP: formin-nucleated actin cable assembly | MF:myosin I binding def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. | MF_def:Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.554716165 cc_score:0.0 bp_score:0.141508 mf_score:0.443678 relationship: child_of NeXO:8950 ! CC: | BP: | MF:profilin binding relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:9475 ! CC: F-actin capping protein complex | BP: barbed-end actin filament capping | MF: [Term] id: NeXO:6509 name: CC: | BP: | MF:polyol transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58946752173726 density:0.333333333333333 bootstrap:0.511543277 cc_score:0.0 bp_score:0.0 mf_score:0.141895 relationship: child_of NeXO:7002 ! CC: | BP: | MF: relationship: linked_to NeXO:7917 ! CC: | BP: D-serine metabolic process | MF:D-serine ammonia-lyase activity [Term] id: NeXO:6508 name: CC: | BP: | MF:glycerol transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [NeXO-GO:term] namespace: NeXO comment: robustness:1.81259831172142 density:1 bootstrap:0.544408615 cc_score:0.0 bp_score:0.0 mf_score:0.297872 relationship: child_of NeXO:6509 ! CC: | BP: | MF:polyol transmembrane transporter activity [Term] id: NeXO:6000 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.04439687051134 density:0.333333333333333 bootstrap:0.4177194 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6212 ! CC: | BP: | MF: [Term] id: NeXO:6503 name: CC: mitochondrial processing peptidase complex | BP: protein processing involved in protein targeting to mitochondrion | MF: def: "CC_def: A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion. | BP_def: The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.12407913510445 density:1 bootstrap:0.747589568 cc_score:0.875255 bp_score:0.351259 mf_score:0.0848497 relationship: child_of NeXO:6504 ! CC: | BP: | MF: [Term] id: NeXO:6502 name: CC: integral to mitochondrial outer membrane | BP: tRNA import into mitochondrion | MF:mitochondrion targeting sequence binding def: "CC_def: Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. | BP_def: The directed movement of tRNA, transfer ribonucleic acid, from the cytoplasm into a mitochondrion. | MF_def:Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [NeXO-GO:term] namespace: NeXO comment: robustness:3.01745264607137 density:0.666666666666667 bootstrap:0.82976262 cc_score:0.122599 bp_score:0.23114 mf_score:0.284077 relationship: child_of NeXO:7969 ! CC: mitochondrial outer membrane translocase complex | BP: outer mitochondrial membrane organization | MF: [Term] id: NeXO:6501 name: CC: | BP: mitochondrial tRNA threonylcarbamoyladenosine modification | MF: def: "CC_def: | BP_def: The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.60683121442611 density:0.3 bootstrap:0.509786836 cc_score:0.0 bp_score:0.216387 mf_score:0.0 relationship: child_of NeXO:7313 ! CC: | BP: | MF: [Term] id: NeXO:6500 name: CC: | BP: | MF:structural constituent of cell wall def: "CC_def: | BP_def: | MF_def:The action of a molecule that contributes to the structural integrity of a cell wall." [NeXO-GO:term] namespace: NeXO comment: robustness:3.66360620610396 density:0.5 bootstrap:0.88800486 cc_score:0.0391555 bp_score:0.0 mf_score:0.151442 relationship: child_of NeXO:6854 ! CC: | BP: | MF: [Term] id: NeXO:6506 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73076031 cc_score:0.0 bp_score:0.0926248 mf_score:0.0 relationship: child_of NeXO:7303 ! CC: | BP: | MF: relationship: linked_to NeXO:9203 ! CC: | BP: | MF:inositol hexakisphosphate 4-kinase activity [Term] id: NeXO:6505 name: CC: eRF1 methyltransferase complex | BP: peptidyl-glutamine methylation | MF: def: "CC_def: A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p. | BP_def: The addition of a methyl group to a glutamine residue in a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64437794275884 density:0.666666666666667 bootstrap:0.63726489 cc_score:0.572783 bp_score:0.569229 mf_score:0.0756216 relationship: child_of NeXO:6676 ! CC: | BP: | MF: [Term] id: NeXO:6504 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.31988418106063 density:0.166666666666667 bootstrap:0.409978325 cc_score:0.0 bp_score:0.0622532 mf_score:0.0359555 relationship: child_of NeXO:6570 ! CC: | BP: | MF: [Term] id: NeXO:8026 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15464485694044 density:1 bootstrap:0.76926016 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8915 ! CC: | BP: | MF:histone acetyltransferase activity relationship: linked_to NeXO:9264 ! CC: | BP: | MF: [Term] id: NeXO:9496 name: CC: integral to endosome membrane | BP: Golgi to plasma membrane protein transport | MF: def: "CC_def: Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. | BP_def: The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.44820480452257 density:1 bootstrap:0.459294604 cc_score:0.146164 bp_score:0.294611 mf_score:0.0 relationship: child_of NeXO:9658 ! CC: | BP: regulation of ceramide biosynthetic process | MF: relationship: linked_to NeXO:9650 ! CC: retromer complex, inner shell | BP: retrograde transport, endosome to Golgi | MF: [Term] id: NeXO:9983 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.95564302718038 density:0.026246719160105 bootstrap:0.111379849 cc_score:0.0 bp_score:0.0926813 mf_score:0.0885477 relationship: child_of NeXO:10025 ! CC: cytoskeleton | BP: mitotic cell cycle | MF:cell cycle [Term] id: NeXO:8462 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39631184205271 density:0.0588235294117647 bootstrap:0.256422708 cc_score:0.0 bp_score:0.0287557 mf_score:0.0 relationship: child_of NeXO:9032 ! CC: | BP: | MF: [Term] id: NeXO:8463 name: CC: astral microtubule | BP: | MF: def: "CC_def: Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.85924817572764 density:0.952380952380952 bootstrap:0.826119 cc_score:0.262497 bp_score:0.0883963 mf_score:0.0 relationship: child_of NeXO:9431 ! CC: dynein complex | BP: nuclear migration | MF:motor activity [Term] id: NeXO:8460 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.797526780133523 density:0.1 bootstrap:0.16992179 cc_score:0.0 bp_score:0.0753459 mf_score:0.0 relationship: child_of NeXO:8878 ! CC: | BP: | MF:SNAP receptor activity [Term] id: NeXO:8466 name: CC: | BP: positive regulation of histone H3-K4 methylation | MF:RNA polymerase II carboxy-terminal domain kinase activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. | MF_def:Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.441462207 cc_score:0.0 bp_score:0.293279 mf_score:0.438749 relationship: child_of NeXO:9107 ! CC: | BP: regulation of translational fidelity | MF: relationship: linked_to NeXO:9520 ! CC: | BP: | MF: [Term] id: NeXO:8467 name: CC: | BP: | MF:3 iron, 4 sulfur cluster binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [NeXO-GO:term] namespace: NeXO comment: robustness:1.13761276702854 density:0.133333333333333 bootstrap:0.174020731 cc_score:0.0 bp_score:0.0 mf_score:0.114526 relationship: child_of NeXO:9377 ! CC: | BP: | MF: [Term] id: NeXO:8464 name: CC: | BP: free ubiquitin chain depolymerization | MF: def: "CC_def: | BP_def: The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.348479851 cc_score:0.0 bp_score:0.441663 mf_score:0.0 relationship: child_of NeXO:9135 ! CC: | BP: | MF: relationship: linked_to NeXO:5708 ! CC: | BP: | MF: relationship: linked_to NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: [Term] id: NeXO:8351 name: CC: | BP: | MF:stretch-activated, cation-selective, calcium channel activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [NeXO-GO:term] namespace: NeXO comment: robustness:1.50836520196125 density:0.666666666666667 bootstrap:0.207341363 cc_score:0.0 bp_score:0.0 mf_score:0.315757 relationship: child_of NeXO:8733 ! CC: | BP: | MF:calcium channel activity [Term] id: NeXO:8468 name: CC: | BP: peptidyl-tyrosine dephosphorylation | MF:protein tyrosine phosphatase activity def: "CC_def: | BP_def: The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. | MF_def:Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:7.65906982235569 density:0.933333333333333 bootstrap:0.71724184 cc_score:0.0 bp_score:0.129581 mf_score:0.116132 relationship: child_of NeXO:8995 ! CC: | BP: ribose phosphate metabolic process | MF:nucleotide biosynthetic process [Term] id: NeXO:8469 name: CC: organelle membrane contact site | BP: | MF: def: "CC_def: A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82630692197436 density:0.0541871921182266 bootstrap:0.289526581 cc_score:0.105875 bp_score:0.0854743 mf_score:0.0 relationship: child_of NeXO:9397 ! CC: | BP: mitochondrial membrane organization | MF: [Term] id: NeXO:9497 name: CC: | BP: signal transduction involved in meiotic recombination checkpoint | MF:translation repressor activity, nucleic acid binding def: "CC_def: | BP_def: A signal transduction process that contributes to a meiotic recombination checkpoint. | MF_def:Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:3.80605465383442 density:0.8 bootstrap:0.325685644 cc_score:0.0 bp_score:0.312564 mf_score:0.139482 relationship: child_of NeXO:9810 ! CC: | BP: histone phosphorylation | MF: [Term] id: NeXO:9642 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.14665642537097 density:0.642857142857143 bootstrap:0.409473743 cc_score:0.0 bp_score:0.098714 mf_score:0.0 relationship: child_of NeXO:9779 ! CC: | BP: | MF: [Term] id: NeXO:8192 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.29937847 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9234 ! CC: | BP: | MF: [Term] id: NeXO:6436 name: CC: | BP: | MF:glycerol-3-phosphate O-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.48826562095336 density:0.0666666666666667 bootstrap:0.662423764 cc_score:0.0 bp_score:0.0 mf_score:0.150514 relationship: child_of NeXO:7474 ! CC: | BP: | MF: [Term] id: NeXO:6435 name: CC: | BP: | MF:formate-tetrahydrofolate ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.173215116 cc_score:0.0 bp_score:0.0609844 mf_score:0.167156 relationship: child_of NeXO:6927 ! CC: | BP: | MF: [Term] id: NeXO:8191 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.55236423800406 density:1 bootstrap:0.399309006 cc_score:0.0 bp_score:0.0676661 mf_score:0.0 relationship: child_of NeXO:8690 ! CC: | BP: | MF: relationship: linked_to NeXO:7807 ! CC: | BP: | MF:mRNA methyltransferase activity [Term] id: NeXO:8196 name: CC: | BP: intra-S DNA damage checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27880585106356 density:1 bootstrap:0.860471516 cc_score:0.0 bp_score:0.12674 mf_score:0.0 relationship: child_of NeXO:8556 ! CC: | BP: | MF: relationship: linked_to NeXO:7082 ! CC: site of double-strand break | BP: | MF: relationship: linked_to NeXO:8152 ! CC: Cul8-RING ubiquitin ligase complex | BP: replication fork processing | MF:H3 histone acetyltransferase activity relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity [Term] id: NeXO:5709 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70230139 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6389 ! CC: | BP: | MF: [Term] id: NeXO:6431 name: CC: | BP: lipid translocation | MF:phospholipid transporter activity def: "CC_def: | BP_def: The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. | MF_def:Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [NeXO-GO:term] namespace: NeXO comment: robustness:4.58322619019356 density:0.145454545454545 bootstrap:0.76493999 cc_score:0.0 bp_score:0.175434 mf_score:0.204429 relationship: child_of NeXO:7175 ! CC: | BP: phospholipid transport | MF:phospholipid transport [Term] id: NeXO:6430 name: CC: | BP: snoRNA splicing | MF: def: "CC_def: | BP_def: The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08512057506257 density:0.333333333333333 bootstrap:0.88032171 cc_score:0.0 bp_score:0.23025 mf_score:0.0 relationship: child_of NeXO:8287 ! CC: | BP: | MF: [Term] id: NeXO:5704 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03167629750967 density:0.333333333333333 bootstrap:0.83577253 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5789 ! CC: | BP: | MF: [Term] id: NeXO:8198 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.531264399 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8646 ! CC: | BP: | MF: [Term] id: NeXO:8199 name: CC: delta DNA polymerase complex | BP: DNA replication proofreading | MF:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity def: "CC_def: A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair. | BP_def: Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.02051591279991 density:1 bootstrap:0.67646666 cc_score:0.220739 bp_score:0.440385 mf_score:0.224692 relationship: child_of NeXO:8859 ! CC: | BP: base-excision repair, base-free sugar-phosphate removal | MF: relationship: linked_to NeXO:8481 ! CC: alpha DNA polymerase:primase complex | BP: DNA replication, synthesis of RNA primer | MF:DNA primase activity [Term] id: NeXO:5700 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.39861984641081 density:0.0476190476190476 bootstrap:0.64894235 cc_score:0.0 bp_score:0.0620275 mf_score:0.0723471 relationship: child_of NeXO:5793 ! CC: | BP: | MF: [Term] id: NeXO:5701 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79638241 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7319 ! CC: | BP: | MF: [Term] id: NeXO:6439 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83621152 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7570 ! CC: | BP: protein delipidation | MF: [Term] id: NeXO:5703 name: CC: | BP: acylglycerol metabolic process | MF:lysophosphatidylethanolamine acyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. | MF_def:Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.63035684856435 density:0.0666666666666667 bootstrap:0.79495098 cc_score:0.0 bp_score:0.123397 mf_score:0.191445 relationship: child_of NeXO:7495 ! CC: | BP: | MF: [Term] id: NeXO:7559 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.59522720648851 density:1 bootstrap:0.71392216 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7908 ! CC: | BP: | MF: [Term] id: NeXO:7553 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.4414016804837 density:0.333333333333333 bootstrap:0.420677334 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7974 ! CC: | BP: | MF: [Term] id: NeXO:7552 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.399712896 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7553 ! CC: | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding [Term] id: NeXO:7551 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.550213304 cc_score:0.0 bp_score:0.0 mf_score:0.069341 relationship: child_of NeXO:7637 ! CC: | BP: | MF: [Term] id: NeXO:7550 name: CC: | BP: | MF:RNA strand annealing activity def: "CC_def: | BP_def: | MF_def:Facilitates the base-pairing of complementary single-stranded RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.739301429 cc_score:0.0 bp_score:0.0 mf_score:0.221803 relationship: child_of NeXO:8689 ! CC: | BP: | MF: relationship: linked_to NeXO:8688 ! CC: multi-eIF complex | BP: mature ribosome assembly | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:7557 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84537971 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8218 ! CC: | BP: | MF: [Term] id: NeXO:7555 name: CC: | BP: positive regulation of protein autophosphorylation | MF:ubiquitin-protein ligase inhibitor activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. | MF_def:Stops, prevents or reduces the activity of a ubiquitin-protein ligase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.328048725 cc_score:0.0 bp_score:0.294041 mf_score:0.441128 relationship: child_of NeXO:7904 ! CC: | BP: | MF:ubiquitin-protein ligase regulator activity [Term] id: NeXO:7554 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86274379 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9309 ! CC: proteasome core complex, beta-subunit complex | BP: endopeptidase activity | MF: relationship: linked_to NeXO:8061 ! CC: proteasome storage granule | BP: | MF: relationship: linked_to NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:7942 ! CC: | BP: | MF: [Term] id: NeXO:6907 name: CC: | BP: | MF:pentose transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:4.99895691414239 density:1 bootstrap:0.690117995 cc_score:0.0 bp_score:0.0416667 mf_score:0.525 relationship: child_of NeXO:7476 ! CC: | BP: | MF:mannose transmembrane transporter activity relationship: linked_to NeXO:8601 ! CC: | BP: mannose transport | MF:glucose binding [Term] id: NeXO:7175 name: CC: | BP: phospholipid transport | MF:phospholipid transport def: "CC_def: | BP_def: The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. | MF_def:The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [NeXO-GO:term] namespace: NeXO comment: robustness:3.9725261606352 density:0.109890109890110 bootstrap:0.508466844 cc_score:0.0 bp_score:0.100732 mf_score:0.135407 relationship: child_of NeXO:7812 ! CC: | BP: | MF: [Term] id: NeXO:6758 name: CC: | BP: | MF:oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [NeXO-GO:term] namespace: NeXO comment: robustness:1.45085314457133 density:0.0666666666666667 bootstrap:0.62953795 cc_score:0.0 bp_score:0.0966591 mf_score:0.108635 relationship: child_of NeXO:8273 ! CC: | BP: | MF: [Term] id: NeXO:6759 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.69214569301782 density:0.333333333333333 bootstrap:0.57976844 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6760 ! CC: | BP: | MF:phospholipase D activity [Term] id: NeXO:6752 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.81002361737767 density:0.333333333333333 bootstrap:0.663357354 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7871 ! CC: | BP: | MF: [Term] id: NeXO:6753 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.72831491436527 density:0.5 bootstrap:0.492477921 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6754 ! CC: | BP: | MF: [Term] id: NeXO:6750 name: CC: | BP: regulation of arginine metabolic process | MF:inositol tetrakisphosphate 6-kinase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. | MF_def:Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [NeXO-GO:term] namespace: NeXO comment: robustness:3.87642282585416 density:1 bootstrap:0.82996631 cc_score:0.0 bp_score:0.295647 mf_score:0.29182 relationship: child_of NeXO:8222 ! CC: | BP: mating type determination | MF: relationship: linked_to NeXO:6466 ! CC: | BP: ornithine biosynthetic process | MF:ornithine carbamoyltransferase inhibitor activity [Term] id: NeXO:6751 name: CC: stress granule | BP: | MF: def: "CC_def: A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.67498636784102 density:1 bootstrap:0.88939403 cc_score:0.129515 bp_score:0.0313748 mf_score:0.0 relationship: child_of NeXO:6771 ! CC: | BP: | MF: [Term] id: NeXO:6756 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.604189401 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7146 ! CC: | BP: | MF: [Term] id: NeXO:6757 name: CC: | BP: mitochondrial alanyl-tRNA aminoacylation | MF:AMP biosynthetic process def: "CC_def: | BP_def: The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.593970396 cc_score:0.0 bp_score:0.214734 mf_score:0.130336 relationship: child_of NeXO:8020 ! CC: | BP: | MF:carbohydrate phosphatase activity [Term] id: NeXO:6754 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26283134460244 density:0.3 bootstrap:0.384120215 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7373 ! CC: | BP: | MF: [Term] id: NeXO:6755 name: CC: | BP: | MF:monovalent cation:hydrogen antiporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.99635796502014 density:0.333333333333333 bootstrap:0.425413952 cc_score:0.0 bp_score:0.0 mf_score:0.103406 relationship: child_of NeXO:7066 ! CC: | BP: | MF: [Term] id: NeXO:9942 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.76549051300272 density:0.092687074829932 bootstrap:0.200534441 cc_score:0.0370848 bp_score:0.0359542 mf_score:0.0112162 relationship: child_of NeXO:10018 ! CC: | BP: | MF: [Term] id: NeXO:9943 name: CC: | BP: | MF:translation factor activity, nucleic acid binding def: "CC_def: | BP_def: | MF_def:Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:6.03476504345456 density:0.052130898021309 bootstrap:0.122087419 cc_score:0.017808 bp_score:0.0640747 mf_score:0.150675 relationship: child_of NeXO:9973 ! CC: | BP: polyadenylation-dependent RNA catabolic process | MF: [Term] id: NeXO:9941 name: CC: | BP: post-Golgi vesicle-mediated transport | MF: def: "CC_def: | BP_def: The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.44875967588065 density:0.0719063545150502 bootstrap:0.09734799 cc_score:0.0672082 bp_score:0.175622 mf_score:0.0694188 relationship: child_of NeXO:9964 ! CC: Golgi apparatus part | BP: vesicle fusion | MF: [Term] id: NeXO:9947 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.86363667553321 density:0.0190097259062776 bootstrap:0.093930302 cc_score:0.0146581 bp_score:0.0430799 mf_score:0.0334776 relationship: child_of NeXO:9974 ! CC: | BP: | MF: [Term] id: NeXO:5810 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.860500166 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6387 ! CC: | BP: | MF: [Term] id: NeXO:5811 name: CC: | BP: | MF:cellulase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [NeXO-GO:term] namespace: NeXO comment: robustness:1.92456855662245 density:0.333333333333333 bootstrap:0.74997336 cc_score:0.0 bp_score:0.0 mf_score:0.314072 relationship: child_of NeXO:6562 ! CC: | BP: | MF:chitin binding [Term] id: NeXO:9948 name: CC: | BP: response to osmotic stress | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.80343363434982 density:0.0511066398390342 bootstrap:0.122812964 cc_score:0.0 bp_score:0.100397 mf_score:0.0551505 relationship: child_of NeXO:9983 ! CC: | BP: | MF: [Term] id: NeXO:9949 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:21.1588322233111 density:0.341724941724942 bootstrap:0.61055454 cc_score:0.0 bp_score:0.0148254 mf_score:0.0 relationship: child_of NeXO:9969 ! CC: | BP: | MF: [Term] id: NeXO:5814 name: CC: | BP: spermidine biosynthetic process | MF:spermine synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. | MF_def:Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [NeXO-GO:term] namespace: NeXO comment: robustness:3.17258324965079 density:0.666666666666667 bootstrap:0.91727381 cc_score:0.0 bp_score:0.213607 mf_score:0.269412 relationship: child_of NeXO:5815 ! CC: | BP: pantothenate biosynthetic process | MF:polyamine oxidase activity [Term] id: NeXO:5815 name: CC: | BP: pantothenate biosynthetic process | MF:polyamine oxidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. | MF_def:Catalysis of the oxidative degradation or interconversion of polyamines." [NeXO-GO:term] namespace: NeXO comment: robustness:2.78356471655867 density:0.333333333333333 bootstrap:0.827060998 cc_score:0.0 bp_score:0.270076 mf_score:0.253034 relationship: child_of NeXO:6419 ! CC: | BP: polyamine biosynthetic process | MF:spermidine synthase activity [Term] id: NeXO:6894 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21645636502263 density:1 bootstrap:0.81402964 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8871 ! CC: | BP: positive regulation of protein import into nucleus | MF: relationship: linked_to NeXO:8628 ! CC: | BP: | MF: [Term] id: NeXO:9379 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.3625034774372 density:0.714285714285714 bootstrap:0.680638838 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9647 ! CC: 90S preribosome | BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:9995 name: CC: pore complex | BP: RNA 3'-end processing | MF: def: "CC_def: Any small opening in a membrane that allows the passage of gases and/or liquids. | BP_def: Any process involved in forming the mature 3' end of an RNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.1859135182147 density:0.0470358231269047 bootstrap:0.202515029 cc_score:0.117668 bp_score:0.151912 mf_score:0.0505415 relationship: child_of NeXO:10024 ! CC: ribonucleoprotein complex | BP: ribonucleoprotein complex biogenesis | MF:structural molecule activity [Term] id: NeXO:7173 name: CC: | BP: | MF:dipeptidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of a dipeptide." [NeXO-GO:term] namespace: NeXO comment: robustness:1.8293218479675 density:1 bootstrap:0.554500688 cc_score:0.0 bp_score:0.0794733 mf_score:0.283583 relationship: child_of NeXO:7742 ! CC: | BP: | MF: relationship: linked_to NeXO:7743 ! CC: | BP: arginine transport | MF:lysine transport relationship: linked_to NeXO:7349 ! CC: | BP: | MF: [Term] id: NeXO:9271 name: CC: | BP: | MF:tRNA-specific adenosine deaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7131719137748 density:0.2 bootstrap:0.354627949 cc_score:0.0 bp_score:0.0 mf_score:0.116446 relationship: child_of NeXO:9526 ! CC: | BP: | MF: relationship: linked_to NeXO:9197 ! CC: | BP: | MF: [Term] id: NeXO:7172 name: CC: | BP: N-acylethanolamine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.49029573353679 density:0.380952380952381 bootstrap:0.558752 cc_score:0.0 bp_score:0.117318 mf_score:0.0 relationship: child_of NeXO:8329 ! CC: | BP: | MF: [Term] id: NeXO:9272 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.213551834 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9623 ! CC: | BP: | MF: [Term] id: NeXO:7396 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.98734729752612 density:0.666666666666667 bootstrap:0.81328801 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8418 ! CC: | BP: cellular response to misfolded protein | MF: [Term] id: NeXO:7391 name: CC: | BP: transcriptional open complex formation at RNA polymerase II promoter | MF: def: "CC_def: | BP_def: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.73799740160283 density:1 bootstrap:0.41406092 cc_score:0.0 bp_score:0.148337 mf_score:0.0 relationship: child_of NeXO:8170 ! CC: | BP: | MF:RNA polymerase II transcription factor recruiting transcription factor activity relationship: linked_to NeXO:7302 ! CC: | BP: | MF:TFIIH-class transcription factor recruiting transcription factor activity relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:9672 ! CC: | BP: | MF: [Term] id: NeXO:5060 name: CC: | BP: pentose-phosphate shunt, oxidative branch | MF:GMP synthase (glutamine-hydrolyzing) activity def: "CC_def: | BP_def: The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). | MF_def:Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72395305 cc_score:0.0 bp_score:0.147875 mf_score:0.440451 relationship: child_of NeXO:5061 ! CC: | BP: | MF: [Term] id: NeXO:9276 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28381082218038 density:0.0849673202614379 bootstrap:0.143095839 cc_score:0.0404116 bp_score:0.0285885 mf_score:0.0317773 relationship: child_of NeXO:9737 ! CC: | BP: | MF: [Term] id: NeXO:7392 name: CC: | BP: L-phenylalanine metabolic process | MF:phosphoglycerate mutase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. | MF_def:Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73265786 cc_score:0.0 bp_score:0.114229 mf_score:0.149128 relationship: child_of NeXO:9400 ! CC: | BP: glucose catabolic process to ethanol | MF:methylglyoxal reductase (NADH-dependent) activity relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:8234 ! CC: | BP: reactive oxygen species metabolic process | MF:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Term] id: NeXO:8112 name: CC: multivesicular body | BP: gamma-aminobutyric acid transport | MF:gamma-aminobutyric acid transport def: "CC_def: A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. | BP_def: The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:2.03619366730437 density:1 bootstrap:0.68700518 cc_score:0.1576 bp_score:0.219619 mf_score:0.212618 relationship: child_of NeXO:9492 ! CC: ER to Golgi transport vesicle membrane | BP: COPII-coated vesicle budding | MF: relationship: linked_to NeXO:7005 ! CC: | BP: tryptophan transport | MF:L-tryptophan transmembrane transporter activity [Term] id: NeXO:5924 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78934755 cc_score:0.0 bp_score:0.0631278 mf_score:0.0 relationship: child_of NeXO:6911 ! CC: | BP: | MF: [Term] id: NeXO:9278 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76732949031692 density:1 bootstrap:0.517555461 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9567 ! CC: | BP: | MF: relationship: linked_to NeXO:8369 ! CC: | BP: | MF:UDP-N-acetylglucosamine diphosphorylase activity relationship: linked_to NeXO:9139 ! CC: | BP: | MF: [Term] id: NeXO:5927 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83874044 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6743 ! CC: | BP: | MF:oligopeptide transmembrane transporter activity [Term] id: NeXO:5920 name: CC: | BP: unidimensional cell growth | MF: def: "CC_def: | BP_def: The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84592849 cc_score:0.0 bp_score:0.292126 mf_score:0.0 relationship: child_of NeXO:6102 ! CC: | BP: | MF: [Term] id: NeXO:5921 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92459365 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5922 ! CC: | BP: zinc ion transport | MF:zinc ion transmembrane transporter activity [Term] id: NeXO:5922 name: CC: | BP: zinc ion transport | MF:zinc ion transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.04224451646468 density:0.333333333333333 bootstrap:0.84449006 cc_score:0.0 bp_score:0.169161 mf_score:0.186132 relationship: child_of NeXO:6446 ! CC: | BP: cellular modified amino acid catabolic process | MF:omega peptidase activity [Term] id: NeXO:5923 name: CC: | BP: tetrahydrobiopterin biosynthetic process | MF:4-alpha-hydroxytetrahydrobiopterin dehydratase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. | MF_def:Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89186073 cc_score:0.0 bp_score:0.439098 mf_score:0.439291 relationship: child_of NeXO:5924 ! CC: | BP: | MF: [Term] id: NeXO:5928 name: CC: | BP: | MF:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84891193 cc_score:0.0 bp_score:0.0 mf_score:0.293038 relationship: child_of NeXO:7003 ! CC: | BP: | MF: [Term] id: NeXO:5929 name: CC: | BP: positive regulation of mitochondrial translational initiation | MF:electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. | MF_def:Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83141403 cc_score:0.0 bp_score:0.440523 mf_score:0.292494 relationship: child_of NeXO:6433 ! CC: | BP: mitochondrial RNA catabolic process | MF: relationship: linked_to NeXO:8573 ! CC: mitochondrial respiratory chain complex IV | BP: mitochondrial electron transport, cytochrome c to oxygen | MF:cytochrome-c oxidase activity [Term] id: NeXO:7442 name: CC: | BP: DNA ligation involved in DNA repair | MF:DNA ligase (ATP) activity def: "CC_def: | BP_def: The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. | MF_def:Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.73425573114 density:0.166666666666667 bootstrap:0.707808096 cc_score:0.0 bp_score:0.163667 mf_score:0.16725 relationship: child_of NeXO:8972 ! CC: | BP: | MF: [Term] id: NeXO:8575 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.71247834149114 density:0.666666666666667 bootstrap:0.642959257 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9281 ! CC: mitochondrial respiratory chain | BP: mitochondrial ATP synthesis coupled electron transport | MF:ubiquinol-cytochrome-c reductase activity relationship: linked_to NeXO:9017 ! CC: | BP: coenzyme transport | MF:4-hydroxybenzoate octaprenyltransferase activity relationship: linked_to NeXO:7895 ! CC: | BP: | MF: [Term] id: NeXO:9375 name: CC: | BP: negative regulation of translation in response to stress | MF: def: "CC_def: | BP_def: Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.88479945312765 density:0.666666666666667 bootstrap:0.75841025 cc_score:0.0 bp_score:0.316501 mf_score:0.0 relationship: child_of NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: [Term] id: NeXO:7420 name: CC: clathrin coat of trans-Golgi network vesicle | BP: | MF: def: "CC_def: A clathrin coat found on a vesicle of the trans-Golgi network. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.39756430661304 density:0.866666666666667 bootstrap:0.74143404 cc_score:0.223558 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7865 ! CC: clathrin vesicle coat | BP: | MF: [Term] id: NeXO:8950 name: CC: | BP: | MF:profilin binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [NeXO-GO:term] namespace: NeXO comment: robustness:4.28220093417172 density:0.533333333333333 bootstrap:0.463923597 cc_score:0.0 bp_score:0.0621066 mf_score:0.120695 relationship: child_of NeXO:9215 ! CC: | BP: | MF: [Term] id: NeXO:8114 name: CC: | BP: inositol biosynthetic process | MF:inositol-3-phosphate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. | MF_def:Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96717030363013 density:1 bootstrap:0.64121809 cc_score:0.0 bp_score:0.294307 mf_score:0.443665 relationship: child_of NeXO:8775 ! CC: | BP: | MF:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity relationship: linked_to NeXO:7057 ! CC: | BP: phosphatidic acid biosynthetic process | MF: relationship: linked_to NeXO:7510 ! CC: | BP: CDP-diacylglycerol metabolic process | MF:CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Term] id: NeXO:7829 name: CC: | BP: tyrosyl-tRNA aminoacylation | MF:tyrosine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.34802064555348 density:0.190476190476190 bootstrap:0.356246692 cc_score:0.0 bp_score:0.103627 mf_score:0.104097 relationship: child_of NeXO:8828 ! CC: | BP: | MF: [Term] id: NeXO:7828 name: CC: | BP: | MF:tRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with transfer RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.55890275751722 density:0.5 bootstrap:0.433216845 cc_score:0.0 bp_score:0.0573313 mf_score:0.134122 relationship: child_of NeXO:7829 ! CC: | BP: tyrosyl-tRNA aminoacylation | MF:tyrosine-tRNA ligase activity [Term] id: NeXO:7340 name: CC: | BP: acyl-CoA metabolic process | MF:long-chain fatty acid transport def: "CC_def: | BP_def: The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. | MF_def:The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12." [NeXO-GO:term] namespace: NeXO comment: robustness:1.12988667966204 density:0.333333333333333 bootstrap:0.258493033 cc_score:0.0 bp_score:0.412221 mf_score:0.307393 relationship: child_of NeXO:7890 ! CC: | BP: long-chain fatty acid transport | MF:fatty acid ligase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:6938 ! CC: | BP: N-terminal peptidyl-glycine N-myristoylation | MF:glycylpeptide N-tetradecanoyltransferase activity [Term] id: NeXO:7823 name: CC: | BP: lysine biosynthetic process via aminoadipic acid | MF:saccharopine dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. | MF_def:Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:5.6643986155295 density:0.392857142857143 bootstrap:0.64764144 cc_score:0.0 bp_score:0.480733 mf_score:0.213013 relationship: child_of NeXO:8003 ! CC: | BP: lysine biosynthetic process | MF: [Term] id: NeXO:7822 name: CC: | BP: arginine biosynthetic process | MF:carboxyl- or carbamoyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. | MF_def:Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.55070000710539 density:0.098901098901099 bootstrap:0.240027194 cc_score:0.0 bp_score:0.193834 mf_score:0.10663 relationship: child_of NeXO:8705 ! CC: | BP: | MF: [Term] id: NeXO:7821 name: CC: | BP: regulation of S phase of mitotic cell cycle | MF:MAP kinase tyrosine/serine/threonine phosphatase activity def: "CC_def: | BP_def: A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle. | MF_def:Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.67068939764865 density:1 bootstrap:0.462501643 cc_score:0.0 bp_score:0.221666 mf_score:0.222593 relationship: child_of NeXO:8436 ! CC: | BP: | MF: relationship: linked_to NeXO:9311 ! CC: | BP: | MF: [Term] id: NeXO:7820 name: CC: | BP: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: | BP_def: Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.435195446 cc_score:0.0 bp_score:0.25108 mf_score:0.0 relationship: child_of NeXO:8750 ! CC: | BP: | MF: [Term] id: NeXO:7825 name: CC: | BP: | MF:transferase activity, transferring amino-acyl groups def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.34488918384301 density:1 bootstrap:0.617961826 cc_score:0.0 bp_score:0.0402022 mf_score:0.134325 relationship: child_of NeXO:8161 ! CC: | BP: | MF: relationship: linked_to NeXO:7045 ! CC: | BP: | MF: [Term] id: NeXO:7824 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.17647834795505 density:1 bootstrap:0.5573012 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8161 ! CC: | BP: | MF: relationship: linked_to NeXO:9067 ! CC: | BP: | MF: [Term] id: NeXO:8682 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.76098924078943 density:0.0392156862745098 bootstrap:0.58606023 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9664 ! CC: | BP: | MF: [Term] id: NeXO:7074 name: CC: | BP: cardiolipin biosynthetic process | MF:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. | MF_def:Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.8442915005948 density:0.2 bootstrap:0.410989 cc_score:0.0 bp_score:0.141695 mf_score:0.216899 relationship: child_of NeXO:7675 ! CC: | BP: | MF: [Term] id: NeXO:7076 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1898351206469 density:0.133333333333333 bootstrap:0.590165309 cc_score:0.0 bp_score:0.0108317 mf_score:0.0 relationship: child_of NeXO:7452 ! CC: | BP: | MF: [Term] id: NeXO:5453 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87967979 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7560 ! CC: | BP: | MF: [Term] id: NeXO:9179 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.0266326358874 density:1 bootstrap:0.624770572 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9581 ! CC: U1 snRNP | BP: | MF: [Term] id: NeXO:9368 name: CC: Cdc73/Paf1 complex | BP: GO:2001173 | MF:TFIIF-class binding transcription factor activity def: "CC_def: A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. | BP_def: | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [NeXO-GO:term] namespace: NeXO comment: robustness:6.55358470651134 density:0.8 bootstrap:0.647720072 cc_score:0.498731 bp_score:0.664668 mf_score:0.304532 relationship: child_of NeXO:9859 ! CC: transcription elongation factor complex | BP: regulation of histone ubiquitination | MF: [Term] id: NeXO:9366 name: CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding def: "CC_def: | BP_def: A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging. | MF_def:Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [NeXO-GO:term] namespace: NeXO comment: robustness:4.51201644047919 density:1 bootstrap:0.562219509 cc_score:0.0 bp_score:0.222011 mf_score:0.293524 relationship: child_of NeXO:9530 ! CC: | BP: | MF: [Term] id: NeXO:7070 name: CC: | BP: MAPKKK cascade involved in conjugation with cellular fusion | MF:calmodulin binding def: "CC_def: | BP_def: A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion. | MF_def:Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [NeXO-GO:term] namespace: NeXO comment: robustness:1.77259271787255 density:0.333333333333333 bootstrap:0.636204866 cc_score:0.0 bp_score:0.160654 mf_score:0.119937 relationship: child_of NeXO:7681 ! CC: | BP: regulation of sporulation | MF: [Term] id: NeXO:9364 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10346822452654 density:0.7 bootstrap:0.257083186 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9755 ! CC: mRNA cleavage factor complex | BP: mRNA polyadenylation | MF: relationship: linked_to NeXO:8129 ! CC: | BP: | MF: [Term] id: NeXO:9365 name: CC: | BP: galactose catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.39009840674144 density:1 bootstrap:0.53224682 cc_score:0.0 bp_score:0.102646 mf_score:0.0680805 relationship: child_of NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:9514 ! CC: | BP: | MF:dolichyl-phosphate beta-glucosyltransferase activity relationship: linked_to NeXO:9711 ! CC: actin filament | BP: negative regulation of actin filament polymerization | MF: relationship: linked_to NeXO:9470 ! CC: | BP: | MF:voltage-gated calcium channel activity [Term] id: NeXO:9362 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.877404057491712 density:0.1 bootstrap:0.205663774 cc_score:0.0 bp_score:0.0905262 mf_score:0.0 relationship: child_of NeXO:9605 ! CC: | BP: | MF: [Term] id: NeXO:9363 name: CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.37632738085233 density:0.9 bootstrap:0.368199837 cc_score:0.0 bp_score:0.10804 mf_score:0.0 relationship: child_of NeXO:9604 ! CC: | BP: | MF: relationship: linked_to NeXO:9212 ! CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: relationship: linked_to NeXO:9309 ! CC: proteasome core complex, beta-subunit complex | BP: endopeptidase activity | MF: [Term] id: NeXO:9361 name: CC: | BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: | BP_def: Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.83831946746808 density:0.0761904761904762 bootstrap:0.363976148 cc_score:0.0 bp_score:0.122058 mf_score:0.0 relationship: child_of NeXO:9647 ! CC: 90S preribosome | BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:7957 name: CC: | BP: | MF:tRNA (cytosine) methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.75949857107403 density:0.666666666666667 bootstrap:0.69395816 cc_score:0.0 bp_score:0.0 mf_score:0.162027 relationship: child_of NeXO:9257 ! CC: | BP: | MF: [Term] id: NeXO:7220 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08155293937153 density:0.333333333333333 bootstrap:0.877311831 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8445 ! CC: | BP: | MF: [Term] id: NeXO:7223 name: CC: | BP: sulfate assimilation | MF:sulfate adenylyltransferase (ATP) activity def: "CC_def: | BP_def: The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. | MF_def:Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [NeXO-GO:term] namespace: NeXO comment: robustness:5.24021577175504 density:0.8 bootstrap:0.61737198 cc_score:0.0 bp_score:0.188515 mf_score:0.217536 relationship: child_of NeXO:7314 ! CC: | BP: regulation of cellular amino acid metabolic process | MF: [Term] id: NeXO:8986 name: CC: | BP: transcriptional start site selection at RNA polymerase II promoter | MF: def: "CC_def: | BP_def: Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.375862208096 density:1 bootstrap:0.84942847 cc_score:0.0 bp_score:0.134301 mf_score:0.0 relationship: child_of NeXO:9325 ! CC: | BP: | MF: [Term] id: NeXO:9168 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.97278621303325 density:1 bootstrap:0.488118801 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9270 ! CC: | BP: | MF: relationship: linked_to NeXO:8807 ! CC: | BP: | MF: relationship: linked_to NeXO:7562 ! CC: | BP: | MF: relationship: linked_to NeXO:9183 ! CC: | BP: | MF: relationship: linked_to NeXO:8882 ! CC: | BP: | MF: [Term] id: NeXO:7952 name: CC: | BP: nuclear polyadenylation-dependent antisense transcript catabolic process | MF:5'-deoxyribose-5-phosphate lyase activity def: "CC_def: | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. | MF_def:Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [NeXO-GO:term] namespace: NeXO comment: robustness:3.57414284341984 density:1 bootstrap:0.70557306 cc_score:0.0 bp_score:0.225345 mf_score:0.293121 relationship: child_of NeXO:8388 ! CC: TRAMP complex | BP: ncRNA polyadenylation | MF:polynucleotide adenylyltransferase activity relationship: linked_to NeXO:9799 ! CC: RNA cap binding complex | BP: | MF: [Term] id: NeXO:8983 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.37305883659508 density:1 bootstrap:0.628414233 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9224 ! CC: | BP: | MF: relationship: linked_to NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9225 ! CC: | BP: | MF: [Term] id: NeXO:7226 name: CC: ER membrane protein complex | BP: protein folding in endoplasmic reticulum | MF: def: "CC_def: A transmembrane protein complex that is involved in protein folding in the endoplasmic reticulum. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. | BP_def: A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.3307550016188 density:1 bootstrap:0.76662402 cc_score:0.627984 bp_score:0.366659 mf_score:0.0 relationship: child_of NeXO:7227 ! CC: | BP: | MF: [Term] id: NeXO:5072 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60379386 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5073 ! CC: | BP: | MF: [Term] id: NeXO:9165 name: CC: | BP: positive regulation of telomere maintenance via telomerase | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.12666940596926 density:1 bootstrap:0.74941402 cc_score:0.0 bp_score:0.292479 mf_score:0.0 relationship: child_of NeXO:9753 ! CC: | BP: | MF: relationship: linked_to NeXO:8257 ! CC: | BP: | MF:Hsp90 protein binding relationship: linked_to NeXO:6541 ! CC: | BP: | MF: relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: relationship: linked_to NeXO:9443 ! CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity relationship: linked_to NeXO:9955 ! CC: | BP: protein import into nucleus, translocation | MF: relationship: linked_to NeXO:9631 ! CC: | BP: | MF: [Term] id: NeXO:9166 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70777679719816 density:0.111111111111111 bootstrap:0.220649285 cc_score:0.0 bp_score:0.0334338 mf_score:0.0 relationship: child_of NeXO:9915 ! CC: DNA-directed RNA polymerase complex | BP: polyadenylation-dependent mRNA catabolic process | MF:nucleotidyltransferase activity [Term] id: NeXO:9167 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15135236419185 density:0.110294117647059 bootstrap:0.216783682 cc_score:0.0 bp_score:0.0623585 mf_score:0.0 relationship: child_of NeXO:9656 ! CC: | BP: | MF: [Term] id: NeXO:8989 name: CC: | BP: folic acid biosynthetic process | MF:methenyltetrahydrofolate cyclohydrolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. | MF_def:Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.73650055583208 density:0.666666666666667 bootstrap:0.682439288 cc_score:0.0 bp_score:0.128906 mf_score:0.2334 relationship: child_of NeXO:9516 ! CC: | BP: | MF: [Term] id: NeXO:8988 name: CC: phosphopyruvate hydratase complex | BP: | MF:phosphopyruvate hydratase activity def: "CC_def: A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. | BP_def: | MF_def:Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:5.52972769120123 density:1 bootstrap:0.506662171 cc_score:0.289541 bp_score:0.0489515 mf_score:0.216207 relationship: child_of NeXO:9413 ! CC: | BP: gluconeogenesis | MF:fructose-bisphosphate aldolase activity [Term] id: NeXO:5074 name: CC: | BP: | MF:2-dehydropantoate 2-reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67499591 cc_score:0.0 bp_score:0.0106076 mf_score:0.192961 relationship: child_of NeXO:5088 ! CC: | BP: histidyl-tRNA aminoacylation | MF:histidine-tRNA ligase activity [Term] id: NeXO:5075 name: CC: | BP: | MF:protein N-terminal asparagine amidohydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the deamidation of an N-terminal asparagine residue in a peptide or protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7622107 cc_score:0.0 bp_score:0.0 mf_score:0.170907 relationship: child_of NeXO:5078 ! CC: | BP: | MF: [Term] id: NeXO:7969 name: CC: mitochondrial outer membrane translocase complex | BP: outer mitochondrial membrane organization | MF: def: "CC_def: A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.2865559812952 density:0.9 bootstrap:0.75978298 cc_score:0.479441 bp_score:0.175415 mf_score:0.0 relationship: child_of NeXO:8795 ! CC: | BP: protein import into mitochondrial matrix | MF:protein channel activity [Term] id: NeXO:6921 name: CC: | BP: mitotic spindle organization in nucleus | MF: def: "CC_def: | BP_def: A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.93589142934107 density:0.80952380952381 bootstrap:0.6706119 cc_score:0.0 bp_score:0.257246 mf_score:0.0 relationship: child_of NeXO:6971 ! CC: DASH complex | BP: regulation of microtubule polymerization or depolymerization | MF:microtubule binding [Term] id: NeXO:9560 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11670347725697 density:0.0888888888888889 bootstrap:0.364054936 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9817 ! CC: | BP: | MF: [Term] id: NeXO:9561 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.8804364081675 density:1 bootstrap:0.657781843 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9768 ! CC: | BP: | MF: relationship: linked_to NeXO:9723 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9587 ! CC: | BP: | MF: relationship: linked_to NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9314 ! CC: | BP: | MF: [Term] id: NeXO:9562 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.46976500832915 density:0.0376811594202899 bootstrap:0.161980837 cc_score:0.0328188 bp_score:0.0515059 mf_score:0.0 relationship: child_of NeXO:9821 ! CC: | BP: | MF: [Term] id: NeXO:9563 name: CC: Seh1-associated complex | BP: | MF: def: "CC_def: A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.29799825942339 density:0.288888888888889 bootstrap:0.345188224 cc_score:0.381948 bp_score:0.0672702 mf_score:0.0 relationship: child_of NeXO:9666 ! CC: | BP: | MF: [Term] id: NeXO:9564 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91555678509381 density:1 bootstrap:0.469506045 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9808 ! CC: | BP: | MF: relationship: linked_to NeXO:9524 ! CC: | BP: | MF: relationship: linked_to NeXO:6966 ! CC: | BP: | MF: relationship: linked_to NeXO:8383 ! CC: | BP: | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:8456 ! CC: | BP: | MF: relationship: linked_to NeXO:8127 ! CC: | BP: | MF: relationship: linked_to NeXO:8786 ! CC: | BP: | MF: [Term] id: NeXO:9565 name: CC: condensed nuclear chromosome | BP: chromosome condensation | MF: def: "CC_def: A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus. | BP_def: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.79036529863243 density:0.116923076923077 bootstrap:0.29039565 cc_score:0.112844 bp_score:0.146994 mf_score:0.0 relationship: child_of NeXO:9867 ! CC: | BP: mitotic spindle organization | MF: [Term] id: NeXO:9566 name: CC: | BP: | MF:phosphatidylinositol bisphosphate phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:6.8745391245681 density:0.181286549707602 bootstrap:0.43347852 cc_score:0.0 bp_score:0.0354063 mf_score:0.155647 relationship: child_of NeXO:9759 ! CC: | BP: | MF: [Term] id: NeXO:9567 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.90291419477173 density:0.8 bootstrap:0.54045204 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9876 ! CC: | BP: | MF: relationship: linked_to NeXO:9131 ! CC: | BP: | MF: [Term] id: NeXO:6240 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.85261989769583 density:1 bootstrap:0.568714754 cc_score:0.0 bp_score:0.0372165 mf_score:0.0 relationship: child_of NeXO:7052 ! CC: | BP: | MF: [Term] id: NeXO:6241 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80903872 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7139 ! CC: | BP: | MF:ribonuclease III activity [Term] id: NeXO:6243 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88783018 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6244 ! CC: | BP: | MF: relationship: linked_to NeXO:7465 ! CC: dynactin complex | BP: establishment of mitotic spindle orientation | MF: [Term] id: NeXO:6244 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94432507846426 density:0.333333333333333 bootstrap:0.765449988 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8018 ! CC: | BP: | MF: [Term] id: NeXO:6245 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.603652363 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6246 ! CC: | BP: | MF: relationship: linked_to NeXO:6414 ! CC: | BP: | MF: [Term] id: NeXO:6246 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.506870097 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6781 ! CC: | BP: | MF: [Term] id: NeXO:6247 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88027785 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6249 ! CC: | BP: | MF: [Term] id: NeXO:5380 name: CC: | BP: GTP cyclohydrolase I activity | MF:GTP cyclohydrolase I activity def: "CC_def: | BP_def: Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+. | MF_def:Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.768795049 cc_score:0.0 bp_score:0.3125 mf_score:0.323805 relationship: child_of NeXO:5486 ! CC: | BP: GO:0052837 | MF:GTP cyclohydrolase activity [Term] id: NeXO:5381 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88036599 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6079 ! CC: | BP: | MF: [Term] id: NeXO:5382 name: CC: | BP: regulation of establishment or maintenance of cell polarity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.792710118 cc_score:0.0 bp_score:0.150399 mf_score:0.0 relationship: child_of NeXO:5487 ! CC: | BP: regulation of macroautophagy | MF: [Term] id: NeXO:5383 name: CC: | BP: negative regulation of phosphate metabolic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87080748 cc_score:0.0 bp_score:0.132891 mf_score:0.0 relationship: child_of NeXO:5823 ! CC: | BP: | MF: [Term] id: NeXO:5384 name: CC: | BP: uracil catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82493443 cc_score:0.0 bp_score:0.315522 mf_score:0.0 relationship: child_of NeXO:8137 ! CC: | BP: uracil metabolic process | MF: [Term] id: NeXO:5385 name: CC: | BP: ceramide biosynthetic process | MF:sphingosine N-acyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. | MF_def:Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [NeXO-GO:term] namespace: NeXO comment: robustness:4.15460319832007 density:1 bootstrap:0.95336078 cc_score:0.0 bp_score:0.380388 mf_score:0.660224 relationship: child_of NeXO:5386 ! CC: | BP: ceramide metabolic process | MF: [Term] id: NeXO:5386 name: CC: | BP: ceramide metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.52258062143269 density:0.5 bootstrap:0.82095557 cc_score:0.0 bp_score:0.165297 mf_score:0.0616224 relationship: child_of NeXO:7043 ! CC: | BP: sphingolipid biosynthetic process | MF: [Term] id: NeXO:5387 name: CC: | BP: cellular response to xenobiotic stimulus | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87978493 cc_score:0.0 bp_score:0.195224 mf_score:0.0 relationship: child_of NeXO:6165 ! CC: | BP: | MF: [Term] id: NeXO:9709 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.02318603339288 density:0.257352941176471 bootstrap:0.265828948 cc_score:0.0 bp_score:0.0344058 mf_score:0.0 relationship: child_of NeXO:9961 ! CC: endoplasmic reticulum part | BP: glycosylation | MF: [Term] id: NeXO:9700 name: CC: pre-replicative complex | BP: progressive alteration of chromatin involved in replicative cell aging | MF: def: "CC_def: A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. | BP_def: A process that results in changes in chromatin structure contributing to replicative cell aging. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.07571071781607 density:0.488888888888889 bootstrap:0.35568144 cc_score:0.194445 bp_score:0.16823 mf_score:0.0 relationship: child_of NeXO:9868 ! CC: chromatin silencing complex | BP: progressive alteration of chromatin involved in cell aging | MF:nucleosome binding [Term] id: NeXO:9701 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.74200045392142 density:0.142857142857143 bootstrap:0.173073423 cc_score:0.0767006 bp_score:0.0453052 mf_score:0.0 relationship: child_of NeXO:9878 ! CC: | BP: membrane docking | MF: [Term] id: NeXO:9702 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.53811720891562 density:0.892857142857143 bootstrap:0.397927516 cc_score:0.0 bp_score:0.02637 mf_score:0.0 relationship: child_of NeXO:9901 ! CC: proteasome complex | BP: proteasome assembly | MF: relationship: linked_to NeXO:9608 ! CC: proteasome core complex | BP: proteasomal ubiquitin-independent protein catabolic process | MF:threonine-type endopeptidase activity relationship: linked_to NeXO:9628 ! CC: proteasome regulatory particle | BP: proteasome regulatory particle assembly | MF: relationship: linked_to NeXO:9417 ! CC: | BP: | MF: [Term] id: NeXO:9703 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.43415654983851 density:0.545454545454545 bootstrap:0.408359208 cc_score:0.0 bp_score:0.0617367 mf_score:0.0 relationship: child_of NeXO:9906 ! CC: microtubule associated complex | BP: cellular component movement | MF: [Term] id: NeXO:9704 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60255865969827 density:0.0114754098360656 bootstrap:0.138080269 cc_score:0.0 bp_score:0.0230282 mf_score:0.0 relationship: child_of NeXO:9821 ! CC: | BP: | MF: [Term] id: NeXO:9705 name: CC: | BP: CVT pathway | MF: def: "CC_def: | BP_def: A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.07006297533396 density:0.219047619047619 bootstrap:0.293440519 cc_score:0.0390648 bp_score:0.181925 mf_score:0.0 relationship: child_of NeXO:9903 ! CC: | BP: microautophagy | MF: [Term] id: NeXO:9707 name: CC: ruffle membrane | BP: actin filament bundle assembly involved in actomyosin contractile ring formation | MF:calcium-dependent protein binding def: "CC_def: The portion of the plasma membrane surrounding a ruffle. | BP_def: A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis. | MF_def:Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [NeXO-GO:term] namespace: NeXO comment: robustness:3.59573835742006 density:1 bootstrap:0.714125178 cc_score:0.294736 bp_score:0.294041 mf_score:0.292291 relationship: child_of NeXO:9836 ! CC: filamentous actin | BP: tubulin complex biogenesis | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:8686 ! CC: actomyosin contractile ring | BP: negative regulation of Arp2/3 complex-mediated actin nucleation | MF:myosin II heavy chain binding relationship: linked_to NeXO:5154 ! CC: | BP: glutamate catabolic process | MF:glutamate decarboxylase activity relationship: linked_to NeXO:9118 ! CC: | BP: microtubule bundle formation | MF: [Term] id: NeXO:8871 name: CC: | BP: positive regulation of protein import into nucleus | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22815462324169 density:0.3 bootstrap:0.372437534 cc_score:0.0 bp_score:0.192292 mf_score:0.0140075 relationship: child_of NeXO:9298 ! CC: | BP: | MF:phosphatidylinositol phosphate 5-phosphatase activity [Term] id: NeXO:8870 name: CC: | BP: regulation of transcription-coupled nucleotide-excision repair | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.3387569520523 density:1 bootstrap:0.615698067 cc_score:0.0 bp_score:0.537255 mf_score:0.0 relationship: child_of NeXO:9175 ! CC: transcriptionally active chromatin | BP: GO:2001209 | MF: relationship: linked_to NeXO:8236 ! CC: | BP: histone ubiquitination | MF: [Term] id: NeXO:8873 name: CC: | BP: | MF:protein-arginine omega-N monomethyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.211102662 cc_score:0.0 bp_score:0.0 mf_score:0.106131 relationship: child_of NeXO:9299 ! CC: | BP: | MF: [Term] id: NeXO:8872 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43021438172983 density:0.133333333333333 bootstrap:0.275051714 cc_score:0.0 bp_score:0.027522 mf_score:0.0 relationship: child_of NeXO:9511 ! CC: | BP: | MF:Rho GTPase activator activity [Term] id: NeXO:7319 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.0933621072214 density:0.0578947368421053 bootstrap:0.62382565 cc_score:0.0 bp_score:0.0220749 mf_score:0.0 relationship: child_of NeXO:8971 ! CC: | BP: | MF: [Term] id: NeXO:7318 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.58799236387056 density:0.333333333333333 bootstrap:0.714925646 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8254 ! CC: | BP: | MF: [Term] id: NeXO:8877 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30679340715529 density:0.666666666666667 bootstrap:0.484942607 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9567 ! CC: | BP: | MF: relationship: linked_to NeXO:6462 ! CC: integral to cytosolic side of endoplasmic reticulum membrane | BP: vesicle fusion with endoplasmic reticulum | MF: relationship: linked_to NeXO:8802 ! CC: | BP: | MF: [Term] id: NeXO:8876 name: CC: | BP: chromatin remodeling at centromere | MF: def: "CC_def: | BP_def: Dynamic structural changes in centromeric DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.3864374003148 density:1 bootstrap:0.80124955 cc_score:0.0 bp_score:0.15677 mf_score:0.0 relationship: child_of NeXO:9610 ! CC: RSC complex | BP: nucleosome disassembly | MF:DNA-dependent ATPase activity relationship: linked_to NeXO:9301 ! CC: SWI/SNF complex | BP: nucleosome mobilization | MF:positive regulation of transcription, DNA-dependent relationship: linked_to NeXO:8506 ! CC: | BP: | MF: [Term] id: NeXO:8879 name: CC: | BP: response to organic nitrogen | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.76785441008341 density:0.217948717948718 bootstrap:0.354860641 cc_score:0.0 bp_score:0.159698 mf_score:0.0584471 relationship: child_of NeXO:9585 ! CC: | BP: | MF: [Term] id: NeXO:7314 name: CC: | BP: regulation of cellular amino acid metabolic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.93975021492239 density:0.355555555555556 bootstrap:0.693604805 cc_score:0.0 bp_score:0.14861 mf_score:0.0837272 relationship: child_of NeXO:8978 ! CC: | BP: cysteine biosynthetic process | MF:cysteine biosynthetic process [Term] id: NeXO:7316 name: CC: | BP: regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter | MF:RNA polymerase II enhancer sequence-specific DNA binding def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.315737654 cc_score:0.0 bp_score:0.294885 mf_score:0.440432 relationship: child_of NeXO:7984 ! CC: | BP: clathrin coat disassembly | MF:homoisocitrate dehydrogenase activity [Term] id: NeXO:7311 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.26381129652497 density:0.761904761904762 bootstrap:0.452777877 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7539 ! CC: | BP: | MF: [Term] id: NeXO:7310 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69185206876669 density:0.5 bootstrap:0.47940234 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8184 ! CC: | BP: | MF: relationship: linked_to NeXO:6987 ! CC: | BP: | MF: relationship: linked_to NeXO:6712 ! CC: | BP: | MF:CoA hydrolase activity relationship: linked_to NeXO:7311 ! CC: | BP: | MF: [Term] id: NeXO:7313 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07467523575469 density:0.111111111111111 bootstrap:0.265052262 cc_score:0.0 bp_score:0.0677044 mf_score:0.0 relationship: child_of NeXO:8354 ! CC: | BP: | MF: [Term] id: NeXO:7312 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.18833914901519 density:0.333333333333333 bootstrap:0.285930099 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8184 ! CC: | BP: | MF: [Term] id: NeXO:9857 name: CC: nucleotide-excision repair complex | BP: mismatch repair | MF:damaged DNA binding def: "CC_def: Any complex formed of proteins that act in nucleotide-excision repair. | BP_def: A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. | MF_def:Interacting selectively and non-covalently with damaged DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:7.94589550919918 density:0.352941176470588 bootstrap:0.309093582 cc_score:0.145193 bp_score:0.22074 mf_score:0.230198 relationship: child_of NeXO:9899 ! CC: | BP: DNA damage checkpoint | MF:double-stranded DNA binding [Term] id: NeXO:6922 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.50573286001972 density:0.333333333333333 bootstrap:0.40149012 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7673 ! CC: | BP: | MF: [Term] id: NeXO:6976 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.04786457155244 density:0.138888888888889 bootstrap:0.53396257 cc_score:0.0 bp_score:0.0985601 mf_score:0.0 relationship: child_of NeXO:7812 ! CC: | BP: | MF: [Term] id: NeXO:6977 name: CC: | BP: glycine biosynthetic process | MF:L-allo-threonine aldolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. | MF_def:Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6563923 cc_score:0.0 bp_score:0.222479 mf_score:0.446556 relationship: child_of NeXO:7977 ! CC: | BP: | MF:ubiquitin activating enzyme activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:6607 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.80902173700188 density:0.166666666666667 bootstrap:0.77015266 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7525 ! CC: | BP: hypoxanthine salvage | MF: [Term] id: NeXO:9343 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76676695490828 density:0.0701754385964912 bootstrap:0.099233712 cc_score:0.0 bp_score:0.0241703 mf_score:0.0 relationship: child_of NeXO:9693 ! CC: | BP: | MF: [Term] id: NeXO:6974 name: CC: | BP: water transport | MF:water channel activity def: "CC_def: | BP_def: The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:3.90589873957507 density:0.285714285714286 bootstrap:0.602059825 cc_score:0.0 bp_score:0.195727 mf_score:0.228552 relationship: child_of NeXO:6975 ! CC: | BP: | MF:water transport [Term] id: NeXO:7030 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08722562296486 density:1 bootstrap:0.72187274 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7280 ! CC: Hrd1p ubiquitin ligase ERAD-L complex | BP: | MF: relationship: linked_to NeXO:8418 ! CC: | BP: cellular response to misfolded protein | MF: [Term] id: NeXO:9015 name: CC: | BP: Golgi vesicle fusion to target membrane | MF: def: "CC_def: | BP_def: The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.61793052197386 density:1 bootstrap:0.72296725 cc_score:0.0 bp_score:0.292426 mf_score:0.0 relationship: child_of NeXO:9512 ! CC: | BP: vacuole inheritance | MF: relationship: linked_to NeXO:9297 ! CC: CORVET complex | BP: regulation of vesicle fusion | MF: [Term] id: NeXO:9016 name: CC: | BP: cell cycle arrest in response to pheromone | MF: def: "CC_def: | BP_def: The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.65646621808314 density:0.666666666666667 bootstrap:0.250056476 cc_score:0.0 bp_score:0.181865 mf_score:0.0 relationship: child_of NeXO:9661 ! CC: nuclear envelope lumen | BP: positive regulation of gluconeogenesis | MF: relationship: linked_to NeXO:8601 ! CC: | BP: mannose transport | MF:glucose binding [Term] id: NeXO:9017 name: CC: | BP: coenzyme transport | MF:4-hydroxybenzoate octaprenyltransferase activity def: "CC_def: | BP_def: The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. | MF_def:Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.42513504024315 density:0.266666666666667 bootstrap:0.69243684 cc_score:0.0 bp_score:0.118272 mf_score:0.136113 relationship: child_of NeXO:9423 ! CC: respiratory chain | BP: respiratory electron transport chain | MF: [Term] id: NeXO:7034 name: CC: | BP: alpha-ketoglutarate transport | MF:alpha-ketoglutarate transport def: "CC_def: | BP_def: The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80748855 cc_score:0.0 bp_score:0.440999 mf_score:0.4375 relationship: child_of NeXO:7504 ! CC: | BP: | MF: [Term] id: NeXO:5499 name: CC: | BP: pentose catabolic process | MF:alcohol dehydrogenase (NADP+) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. | MF_def:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.33268947752093 density:0.138888888888889 bootstrap:0.638423969 cc_score:0.0 bp_score:0.122793 mf_score:0.167158 relationship: child_of NeXO:6357 ! CC: | BP: | MF:aldo-keto reductase (NADP) activity [Term] id: NeXO:9012 name: CC: | BP: ribophagy | MF: def: "CC_def: | BP_def: The process in which cells degrade mature ribosomes under conditions of starvation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07571690018566 density:1 bootstrap:0.71393404 cc_score:0.0 bp_score:0.584781 mf_score:0.0 relationship: child_of NeXO:9595 ! CC: | BP: regulation of retrograde vesicle-mediated transport, Golgi to ER | MF: relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: [Term] id: NeXO:7037 name: CC: | BP: response to copper ion | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97327325942337 density:1 bootstrap:0.645202896 cc_score:0.0 bp_score:0.144709 mf_score:0.07079 relationship: child_of NeXO:7513 ! CC: | BP: | MF: [Term] id: NeXO:7038 name: CC: integral to peroxisomal membrane | BP: protein import into peroxisome matrix, receptor recycling | MF: def: "CC_def: Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. | BP_def: The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.80537979396053 density:1 bootstrap:0.67297941 cc_score:0.178931 bp_score:0.333535 mf_score:0.0 relationship: child_of NeXO:8678 ! CC: | BP: | MF: [Term] id: NeXO:6972 name: CC: 6-phosphofructokinase complex | BP: glutamate-cysteine ligase activity | MF:glutamate-cysteine ligase activity def: "CC_def: A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. | BP_def: Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. | MF_def:Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.354680267 cc_score:0.291934 bp_score:0.4375 mf_score:0.438085 relationship: child_of NeXO:7588 ! CC: | BP: positive regulation of exocytosis | MF:glutathione biosynthetic process [Term] id: NeXO:5496 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78923031 cc_score:0.0 bp_score:0.0 mf_score:0.0698254 relationship: child_of NeXO:6568 ! CC: | BP: | MF: [Term] id: NeXO:5497 name: CC: | BP: small-subunit processome assembly | MF:hydroxymethylfurfural reductase (NADPH) activity def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. | MF_def:Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68864407 cc_score:0.0 bp_score:0.293538 mf_score:0.43816 relationship: child_of NeXO:5498 ! CC: | BP: furaldehyde metabolic process | MF:hydroxymethylfurfural reductase (NADH) activity [Term] id: NeXO:9018 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.44608961710172 density:0.533333333333333 bootstrap:0.50011376 cc_score:0.0407 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9433 ! CC: | BP: SNARE complex assembly | MF: [Term] id: NeXO:5491 name: CC: | BP: | MF:glutathione transferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88285585 cc_score:0.0 bp_score:0.054567 mf_score:0.110513 relationship: child_of NeXO:6432 ! CC: | BP: ammonium transport | MF: [Term] id: NeXO:5492 name: CC: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) | BP: | MF: def: "CC_def: The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.72411152212492 density:0.1 bootstrap:0.794125666 cc_score:0.343011 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8437 ! CC: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | BP: proton-transporting ATPase activity, rotational mechanism | MF:proton-transporting ATPase activity, rotational mechanism [Term] id: NeXO:6973 name: CC: | BP: ascospore-type prospore membrane assembly | MF: def: "CC_def: | BP_def: The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.69271058040967 density:0.238095238095238 bootstrap:0.672175482 cc_score:0.0 bp_score:0.122865 mf_score:0.0 relationship: child_of NeXO:7403 ! CC: | BP: | MF: [Term] id: NeXO:9385 name: CC: | BP: maturation of 5S rRNA | MF: def: "CC_def: | BP_def: Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.37229152993665 density:1 bootstrap:0.67282522 cc_score:0.0 bp_score:0.147216 mf_score:0.0 relationship: child_of NeXO:9829 ! CC: U4/U6 x U5 tri-snRNP complex | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding relationship: linked_to NeXO:8838 ! CC: | BP: cis assembly of pre-catalytic spliceosome | MF: [Term] id: NeXO:5250 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.827494135 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6075 ! CC: | BP: | MF:ADP-ribose diphosphatase activity [Term] id: NeXO:5251 name: CC: | BP: negative regulation of GTPase activity | MF:GTPase inhibitor activity def: "CC_def: | BP_def: Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. | MF_def:Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6438316 cc_score:0.0 bp_score:0.439586 mf_score:0.292409 relationship: child_of NeXO:5484 ! CC: | BP: | MF: [Term] id: NeXO:6970 name: CC: | BP: UDP-glucose transport | MF:UDP-glucose transport def: "CC_def: | BP_def: The directed movement of UDP-glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. | MF_def:The directed movement of UDP-glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64792068 cc_score:0.0 bp_score:0.127512 mf_score:0.125125 relationship: child_of NeXO:8593 ! CC: | BP: | MF: [Term] id: NeXO:9382 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.39906242 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9672 ! CC: | BP: | MF: relationship: linked_to NeXO:8805 ! CC: DUBm complex | BP: histone deubiquitination | MF:histone H3-K18 acetylation relationship: linked_to NeXO:6417 ! CC: | BP: removal of superoxide radicals | MF:thioredoxin-disulfide reductase activity relationship: linked_to NeXO:9264 ! CC: | BP: | MF: relationship: linked_to NeXO:8661 ! CC: | BP: | MF: [Term] id: NeXO:9383 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.30155947195 density:0.909090909090909 bootstrap:0.594837735 cc_score:0.0 bp_score:0.0 mf_score:0.0838936 relationship: child_of NeXO:9742 ! CC: core mediator complex | BP: | MF:RNA polymerase II transcription cofactor activity [Term] id: NeXO:9137 name: CC: | BP: | MF:MAP-kinase scaffold activity def: "CC_def: | BP_def: | MF_def:The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [NeXO-GO:term] namespace: NeXO comment: robustness:2.12328126534825 density:1 bootstrap:0.747028038 cc_score:0.0 bp_score:0.0610747 mf_score:0.221995 relationship: child_of NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity relationship: linked_to NeXO:9341 ! CC: heterotrimeric G-protein complex | BP: osmosensory signaling pathway via Sho1 osmosensor | MF:protein domain specific binding relationship: linked_to NeXO:7818 ! CC: | BP: activation of MAPKKK activity involved in osmosensory signaling pathway | MF:mitogen-activated protein kinase kinase kinase binding relationship: linked_to NeXO:7681 ! CC: | BP: regulation of sporulation | MF: [Term] id: NeXO:5258 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77399401 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5420 ! CC: | BP: | MF: [Term] id: NeXO:5259 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81162402 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6025 ! CC: | BP: | MF: relationship: linked_to NeXO:9067 ! CC: | BP: | MF: [Term] id: NeXO:9389 name: CC: | BP: negative regulation of nuclear mRNA splicing, via spliceosome | MF:pre-mRNA 5'-splice site binding def: "CC_def: | BP_def: Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. | MF_def:Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [NeXO-GO:term] namespace: NeXO comment: robustness:2.1372419509392 density:1 bootstrap:0.75688383 cc_score:0.0 bp_score:0.439748 mf_score:0.129339 relationship: child_of NeXO:9621 ! CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: relationship: linked_to NeXO:9533 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: [Term] id: NeXO:9570 name: CC: | BP: carbohydrate transport | MF:fructose transport def: "CC_def: | BP_def: The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. | MF_def:The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [NeXO-GO:term] namespace: NeXO comment: robustness:7.31037098192131 density:0.251461988304094 bootstrap:0.321822616 cc_score:0.0 bp_score:0.166774 mf_score:0.231553 relationship: child_of NeXO:9813 ! CC: | BP: | MF: [Term] id: NeXO:9952 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.73370014937468 density:0.00924121905442846 bootstrap:0.101817994 cc_score:0.0550833 bp_score:0.0478085 mf_score:0.0405357 relationship: child_of NeXO:9970 ! CC: | BP: | MF: [Term] id: NeXO:7923 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.26627733125464 density:0.833333333333333 bootstrap:0.37584392 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8364 ! CC: | BP: | MF: relationship: linked_to NeXO:7922 ! CC: | BP: | MF: [Term] id: NeXO:9345 name: CC: | BP: tricarboxylic acid cycle | MF: def: "CC_def: | BP_def: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.22261859012966 density:0.0711237553342817 bootstrap:0.216787903 cc_score:0.0 bp_score:0.18033 mf_score:0.0335998 relationship: child_of NeXO:9797 ! CC: | BP: cofactor catabolic process | MF: [Term] id: NeXO:7788 name: CC: | BP: | MF:C-4 methylsterol oxidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:3.14978901777615 density:1 bootstrap:0.547975458 cc_score:0.0 bp_score:0.0 mf_score:0.295906 relationship: child_of NeXO:8420 ! CC: | BP: | MF: relationship: linked_to NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity [Term] id: NeXO:7789 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76224041295812 density:1 bootstrap:0.51457912 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8744 ! CC: | BP: | MF: relationship: linked_to NeXO:7517 ! CC: | BP: nuclear mRNA 5'-splice site recognition | MF: relationship: linked_to NeXO:9025 ! CC: | BP: mRNA splice site selection | MF:U1 snRNA binding relationship: linked_to NeXO:8393 ! CC: | BP: | MF: relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: [Term] id: NeXO:7786 name: CC: | BP: RNA import into nucleus | MF:tRNA transport def: "CC_def: | BP_def: The import of RNA from the cytoplasm to the nucleus. | MF_def:The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.463913464 cc_score:0.0 bp_score:0.292701 mf_score:0.4375 relationship: child_of NeXO:8367 ! CC: | BP: | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity [Term] id: NeXO:7784 name: CC: | BP: aspartate family amino acid catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.89958754624318 density:0.218181818181818 bootstrap:0.525176665 cc_score:0.0 bp_score:0.174448 mf_score:0.0773544 relationship: child_of NeXO:7978 ! CC: | BP: glutamine family amino acid catabolic process | MF: [Term] id: NeXO:7785 name: CC: | BP: | MF:beta-tubulin binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81386137 cc_score:0.0 bp_score:0.0 mf_score:0.202237 relationship: child_of NeXO:8559 ! CC: | BP: | MF: [Term] id: NeXO:7782 name: CC: | BP: protein processing | MF:calcium-dependent cysteine-type endopeptidase activity def: "CC_def: | BP_def: Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. | MF_def:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [NeXO-GO:term] namespace: NeXO comment: robustness:7.38634318555452 density:1 bootstrap:0.90400317 cc_score:0.0 bp_score:0.100315 mf_score:0.177853 relationship: child_of NeXO:8597 ! CC: | BP: | MF: [Term] id: NeXO:9579 name: CC: | BP: pentose biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.61744232332309 density:0.189723320158103 bootstrap:0.257535179 cc_score:0.0 bp_score:0.124943 mf_score:0.0156605 relationship: child_of NeXO:9738 ! CC: | BP: | MF: [Term] id: NeXO:7780 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.02000483663383 density:1 bootstrap:0.89872586 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8638 ! CC: | BP: | MF: [Term] id: NeXO:7781 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.9364736868861 density:0.666666666666667 bootstrap:0.78582378 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8578 ! CC: TFIIK complex | BP: | MF: [Term] id: NeXO:7148 name: CC: | BP: | MF:sterol binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [NeXO-GO:term] namespace: NeXO comment: robustness:1.07590239248835 density:0.1 bootstrap:0.309246128 cc_score:0.0 bp_score:0.0 mf_score:0.143858 relationship: child_of NeXO:7689 ! CC: | BP: | MF:sterol transporter activity [Term] id: NeXO:9346 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.39639678392544 density:0.333333333333333 bootstrap:0.312676233 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9591 ! CC: | BP: | MF: [Term] id: NeXO:7144 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.214888497 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8139 ! CC: | BP: negative regulation of TOR signaling cascade | MF: [Term] id: NeXO:7146 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.14964507560482 density:0.0277777777777778 bootstrap:0.530132875 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8107 ! CC: | BP: | MF: [Term] id: NeXO:7147 name: CC: mitochondrial intermembrane space protein transporter complex | BP: inner mitochondrial membrane organization | MF: def: "CC_def: Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.32568394741177 density:0.285714285714286 bootstrap:0.56066079 cc_score:0.230821 bp_score:0.155387 mf_score:0.0 relationship: child_of NeXO:8615 ! CC: | BP: | MF: [Term] id: NeXO:7140 name: CC: | BP: | MF:3-dehydrosphinganine reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.347752048 cc_score:0.0 bp_score:0.0 mf_score:0.313077 relationship: child_of NeXO:7762 ! CC: | BP: | MF:phosphatidylinositol phospholipase C activity [Term] id: NeXO:7141 name: CC: | BP: | MF:inorganic diphosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.64259365477252 density:0.333333333333333 bootstrap:0.546310247 cc_score:0.0 bp_score:0.0 mf_score:0.229792 relationship: child_of NeXO:8291 ! CC: | BP: | MF: [Term] id: NeXO:7142 name: CC: | BP: | MF:[acyl-carrier-protein] S-acetyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [NeXO-GO:term] namespace: NeXO comment: robustness:1.63249207623976 density:0.333333333333333 bootstrap:0.53961154 cc_score:0.0 bp_score:0.0805787 mf_score:0.31769 relationship: child_of NeXO:8288 ! CC: | BP: extrachromosomal rDNA circle accumulation involved in replicative cell aging | MF:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [Term] id: NeXO:7143 name: CC: | BP: potassium ion import | MF: def: "CC_def: | BP_def: The directed movement of potassium ions into a cell or organelle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.49484928900955 density:0.666666666666667 bootstrap:0.567233107 cc_score:0.0 bp_score:0.273958 mf_score:0.0560176 relationship: child_of NeXO:7632 ! CC: | BP: pyruvate transport | MF: [Term] id: NeXO:8729 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.292700507 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9463 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: [Term] id: NeXO:8249 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91535576000903 density:0.0769230769230769 bootstrap:0.43347805 cc_score:0.0 bp_score:0.0387743 mf_score:0.0 relationship: child_of NeXO:8932 ! CC: | BP: | MF: [Term] id: NeXO:9867 name: CC: | BP: mitotic spindle organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.36927681054058 density:0.0417768376520360 bootstrap:0.122340992 cc_score:0.0773456 bp_score:0.101065 mf_score:0.0140861 relationship: child_of NeXO:9986 ! CC: spliceosomal complex | BP: RNA splicing, via transesterification reactions | MF: [Term] id: NeXO:8721 name: CC: condensed nuclear chromosome, centromeric region | BP: microtubule polymerization or depolymerization | MF:tubulin binding def: "CC_def: The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. | BP_def: Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. | MF_def:Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [NeXO-GO:term] namespace: NeXO comment: robustness:7.08870086211751 density:0.274725274725275 bootstrap:0.50295128 cc_score:0.102948 bp_score:0.251786 mf_score:0.169383 relationship: child_of NeXO:9565 ! CC: condensed nuclear chromosome | BP: chromosome condensation | MF: [Term] id: NeXO:8720 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.181373726 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9570 ! CC: | BP: carbohydrate transport | MF:fructose transport [Term] id: NeXO:8723 name: CC: | BP: bipolar cellular bud site selection | MF: def: "CC_def: | BP_def: The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.48199653243183 density:0.714285714285714 bootstrap:0.702911593 cc_score:0.0 bp_score:0.14013 mf_score:0.0 relationship: child_of NeXO:9310 ! CC: exocyst | BP: vesicle docking involved in exocytosis | MF: [Term] id: NeXO:8722 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.12919141915344 density:0.0513833992094862 bootstrap:0.151507082 cc_score:0.0 bp_score:0.0187142 mf_score:0.0 relationship: child_of NeXO:9455 ! CC: | BP: | MF: [Term] id: NeXO:8725 name: CC: phosphatidylinositol 3-kinase complex | BP: | MF: def: "CC_def: A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.19640378125352 density:0.166666666666667 bootstrap:0.3368564 cc_score:0.223768 bp_score:0.0962447 mf_score:0.0 relationship: child_of NeXO:9457 ! CC: | BP: | MF: relationship: linked_to NeXO:9650 ! CC: retromer complex, inner shell | BP: retrograde transport, endosome to Golgi | MF: [Term] id: NeXO:8724 name: CC: vacuolar proton-transporting V-type ATPase complex | BP: ATP hydrolysis coupled proton transport | MF:proton transport def: "CC_def: A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. | BP_def: The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis. | MF_def:The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:19.441913670904 density:0.783333333333333 bootstrap:0.74523011 cc_score:0.568761 bp_score:0.441486 mf_score:0.115733 relationship: child_of NeXO:8938 ! CC: proton-transporting two-sector ATPase complex | BP: regulation of intracellular pH | MF:ATPase activity, coupled to transmembrane movement of ions [Term] id: NeXO:8727 name: CC: | BP: | MF:osmosensor activity def: "CC_def: | BP_def: | MF_def:Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [NeXO-GO:term] namespace: NeXO comment: robustness:3.42561770109619 density:1 bootstrap:0.64815066 cc_score:0.0 bp_score:0.0123351 mf_score:0.145974 relationship: child_of NeXO:9531 ! CC: | BP: | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: [Term] id: NeXO:8726 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.469351318 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9080 ! CC: | BP: | MF: relationship: linked_to NeXO:8646 ! CC: | BP: | MF: [Term] id: NeXO:8053 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28255116381654 density:0.133333333333333 bootstrap:0.255674036 cc_score:0.0 bp_score:0.0192239 mf_score:0.0 relationship: child_of NeXO:8685 ! CC: | BP: | MF: [Term] id: NeXO:8500 name: CC: | BP: | MF:ribonucleoside binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [NeXO-GO:term] namespace: NeXO comment: robustness:2.22991210136336 density:1 bootstrap:0.823943317 cc_score:0.0 bp_score:0.0 mf_score:0.182807 relationship: child_of NeXO:9678 ! CC: DNA-directed RNA polymerase I complex | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:5935 ! CC: | BP: | MF:RNA polymerase I regulatory region sequence-specific DNA binding relationship: linked_to NeXO:7526 ! CC: | BP: | MF: relationship: linked_to NeXO:8557 ! CC: | BP: | MF:transcription from RNA polymerase III promoter [Term] id: NeXO:8051 name: CC: | BP: threonine catabolic process | MF:flavin reductase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:4.17254754527754 density:0.833333333333333 bootstrap:0.613343834 cc_score:0.0 bp_score:0.141026 mf_score:0.201372 relationship: child_of NeXO:8927 ! CC: | BP: aromatic amino acid family biosynthetic process | MF:carbon-oxygen lyase activity, acting on phosphates [Term] id: NeXO:8502 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.34828825789599 density:0.0513833992094862 bootstrap:0.184291936 cc_score:0.0 bp_score:0.0339936 mf_score:0.0289158 relationship: child_of NeXO:9455 ! CC: | BP: | MF: [Term] id: NeXO:8505 name: CC: | BP: meiotic anaphase II | MF: def: "CC_def: | BP_def: Anaphase occurring as part of meiosis II. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.45455322828992 density:1 bootstrap:0.65914651 cc_score:0.0 bp_score:0.294039 mf_score:0.0 relationship: child_of NeXO:9687 ! CC: | BP: | MF: [Term] id: NeXO:8504 name: CC: | BP: re-entry into mitotic cell cycle | MF: def: "CC_def: | BP_def: The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.86320156344833 density:0.189723320158103 bootstrap:0.57212648 cc_score:0.0 bp_score:0.178269 mf_score:0.0 relationship: child_of NeXO:9256 ! CC: | BP: | MF: [Term] id: NeXO:8507 name: CC: | BP: mitochondrial DNA packaging | MF: def: "CC_def: | BP_def: Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.582635013 cc_score:0.0 bp_score:0.439069 mf_score:0.0 relationship: child_of NeXO:8959 ! CC: | BP: | MF: relationship: linked_to NeXO:8506 ! CC: | BP: | MF: [Term] id: NeXO:8054 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.9082385276674 density:1 bootstrap:0.83912428 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9002 ! CC: | BP: | MF: [Term] id: NeXO:8509 name: CC: Atg12-Atg5-Atg16 complex | BP: | MF: def: "CC_def: A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75299504675023 density:1 bootstrap:0.509193938 cc_score:0.218788 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9035 ! CC: | BP: | MF: [Term] id: NeXO:8058 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.85649989629274 density:0.333333333333333 bootstrap:0.697860992 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8604 ! CC: | BP: | MF: relationship: linked_to NeXO:9757 ! CC: | BP: actin cortical patch localization | MF: [Term] id: NeXO:6492 name: CC: | BP: nuclear polyadenylation-dependent CUT catabolic process | MF:poly(U) RNA binding def: "CC_def: | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. | MF_def:Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.78456498967757 density:1 bootstrap:0.52769938 cc_score:0.0 bp_score:0.177925 mf_score:0.221698 relationship: child_of NeXO:7565 ! CC: | BP: | MF: relationship: linked_to NeXO:8576 ! CC: | BP: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription | MF:3'-5'-exoribonuclease activity [Term] id: NeXO:8291 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.735109519908422 density:0.0476190476190476 bootstrap:0.179271329 cc_score:0.0 bp_score:0.029048 mf_score:0.0 relationship: child_of NeXO:8996 ! CC: | BP: | MF:copper ion binding [Term] id: NeXO:6537 name: CC: | BP: lipoate biosynthetic process | MF:S-adenosylmethionine transmembrane transporter activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. | MF_def:Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [NeXO-GO:term] namespace: NeXO comment: robustness:1.38946461461359 density:0.166666666666667 bootstrap:0.454343408 cc_score:0.0 bp_score:0.135619 mf_score:0.16566 relationship: child_of NeXO:6770 ! CC: | BP: azole transport | MF:azole transporter activity [Term] id: NeXO:5661 name: CC: | BP: negative regulation of sporulation resulting in formation of a cellular spore | MF:MAP kinase tyrosine phosphatase activity def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation. | MF_def:Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.657378791 cc_score:0.0 bp_score:0.29511 mf_score:0.440101 relationship: child_of NeXO:5662 ! CC: | BP: inactivation of MAPK activity involved in cell wall biogenesis | MF: [Term] id: NeXO:6535 name: CC: | BP: | MF:endopeptidase inhibitor activity def: "CC_def: | BP_def: | MF_def:Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [NeXO-GO:term] namespace: NeXO comment: robustness:1.89772232554376 density:1 bootstrap:0.59674279 cc_score:0.0 bp_score:0.0 mf_score:0.145236 relationship: child_of NeXO:6759 ! CC: | BP: | MF: [Term] id: NeXO:5666 name: CC: | BP: L-methionine salvage | MF:S-methyl-5-thioadenosine phosphorylase activity def: "CC_def: | BP_def: Any process that generates L-methionine from derivatives of it, without de novo synthesis. | MF_def:Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52334893 cc_score:0.0 bp_score:0.114764 mf_score:0.439604 relationship: child_of NeXO:6975 ! CC: | BP: | MF:water transport [Term] id: NeXO:5665 name: CC: | BP: | MF:calcium:hydrogen antiporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63940832 cc_score:0.0 bp_score:0.0592969 mf_score:0.296113 relationship: child_of NeXO:6036 ! CC: | BP: | MF:sodium:hydrogen antiporter activity [Term] id: NeXO:6531 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80597367 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7419 ! CC: | BP: | MF:SUMO ligase activity relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding [Term] id: NeXO:8299 name: CC: translocon complex | BP: | MF: def: "CC_def: A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18589977813678 density:0.666666666666667 bootstrap:0.435445124 cc_score:0.117139 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9236 ! CC: | BP: | MF: [Term] id: NeXO:8298 name: CC: COPII vesicle coat | BP: regulation of COPII vesicle coating | MF: def: "CC_def: One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. | BP_def: Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.13306719218359 density:1 bootstrap:0.72764318 cc_score:0.39815 bp_score:0.29753 mf_score:0.0 relationship: child_of NeXO:9492 ! CC: ER to Golgi transport vesicle membrane | BP: COPII-coated vesicle budding | MF: relationship: linked_to NeXO:9568 ! CC: | BP: Golgi vesicle docking | MF: [Term] id: NeXO:5669 name: CC: CAAX-protein geranylgeranyltransferase complex | BP: C-terminal protein methylation | MF:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity def: "CC_def: A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. | BP_def: The methylation of the C-terminal amino acid of a protein. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88466486 cc_score:0.291749 bp_score:0.29503 mf_score:0.444965 relationship: child_of NeXO:6037 ! CC: protein farnesyltransferase complex | BP: protein farnesylation | MF:protein farnesyltransferase activity [Term] id: NeXO:5668 name: CC: | BP: protein geranylgeranylation | MF:CAAX-protein geranylgeranyltransferase activity def: "CC_def: | BP_def: The covalent attachment of a geranylgeranyl group to a protein. | MF_def:Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8852264 cc_score:0.0 bp_score:0.171474 mf_score:0.309499 relationship: child_of NeXO:6037 ! CC: protein farnesyltransferase complex | BP: protein farnesylation | MF:protein farnesyltransferase activity [Term] id: NeXO:8792 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33199778433476 density:0.0366666666666667 bootstrap:0.247570962 cc_score:0.0 bp_score:0.0198965 mf_score:0.032735 relationship: child_of NeXO:9444 ! CC: | BP: | MF: [Term] id: NeXO:6538 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83393531 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7428 ! CC: | BP: error-prone translesion synthesis | MF: [Term] id: NeXO:6539 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.540734395 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7088 ! CC: | BP: | MF: [Term] id: NeXO:5071 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58940365 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5072 ! CC: | BP: | MF: [Term] id: NeXO:7492 name: CC: SAS acetyltransferase complex | BP: | MF: def: "CC_def: A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.95348637467429 density:1 bootstrap:0.8632939 cc_score:0.895213 bp_score:0.0 mf_score:0.0746793 relationship: child_of NeXO:8660 ! CC: | BP: | MF: [Term] id: NeXO:7493 name: CC: | BP: | MF:C-8 sterol isomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [NeXO-GO:term] namespace: NeXO comment: robustness:7.72868981677907 density:0.80952380952381 bootstrap:0.636050467 cc_score:0.0 bp_score:0.0 mf_score:0.173784 relationship: child_of NeXO:8420 ! CC: | BP: | MF: [Term] id: NeXO:7490 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.82982259266582 density:0.00833333333333333 bootstrap:0.496594532 cc_score:0.0 bp_score:0.0143004 mf_score:0.0 relationship: child_of NeXO:9028 ! CC: | BP: | MF: [Term] id: NeXO:7491 name: CC: | BP: positive regulation of ARF protein signal transduction | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.33719464 cc_score:0.0 bp_score:0.442864 mf_score:0.0 relationship: child_of NeXO:8139 ! CC: | BP: negative regulation of TOR signaling cascade | MF: [Term] id: NeXO:7496 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.04813419962866 density:0.0277777777777778 bootstrap:0.440647138 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8390 ! CC: | BP: | MF: [Term] id: NeXO:7497 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.49857127224251 density:0.166666666666667 bootstrap:0.52849886 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8390 ! CC: | BP: | MF: [Term] id: NeXO:7495 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05117741494337 density:0.0888888888888889 bootstrap:0.341863968 cc_score:0.0 bp_score:0.0294222 mf_score:0.0723386 relationship: child_of NeXO:8449 ! CC: lipid particle | BP: | MF: [Term] id: NeXO:8615 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.23332355149095 density:0.0736842105263158 bootstrap:0.281714131 cc_score:0.0 bp_score:0.0648765 mf_score:0.0 relationship: child_of NeXO:9397 ! CC: | BP: mitochondrial membrane organization | MF: [Term] id: NeXO:8614 name: CC: | BP: protein import into peroxisome matrix, docking | MF:peroxisome matrix targeting signal-1 binding def: "CC_def: | BP_def: The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the preoxisomal membrane. | MF_def:Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [NeXO-GO:term] namespace: NeXO comment: robustness:5.91168283394565 density:1 bootstrap:0.5790729 cc_score:0.0 bp_score:0.361858 mf_score:0.175975 relationship: child_of NeXO:9218 ! CC: | BP: protein import into peroxisome matrix | MF: relationship: linked_to NeXO:7038 ! CC: integral to peroxisomal membrane | BP: protein import into peroxisome matrix, receptor recycling | MF: relationship: linked_to NeXO:8306 ! CC: | BP: | MF: [Term] id: NeXO:8610 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.99105003813906 density:1 bootstrap:0.809833635 cc_score:0.0 bp_score:0.0322749 mf_score:0.0 relationship: child_of NeXO:9678 ! CC: DNA-directed RNA polymerase I complex | BP: | MF: [Term] id: NeXO:8613 name: CC: | BP: | MF:ATP-dependent peptidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [NeXO-GO:term] namespace: NeXO comment: robustness:1.76406185620664 density:0.190476190476190 bootstrap:0.201082667 cc_score:0.0 bp_score:0.0229896 mf_score:0.135953 relationship: child_of NeXO:9044 ! CC: | BP: | MF: [Term] id: NeXO:8612 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.70986098671515 density:0.377777777777778 bootstrap:0.600825392 cc_score:0.0 bp_score:0.0595134 mf_score:0.0818191 relationship: child_of NeXO:9142 ! CC: | BP: glycogen metabolic process | MF:protein phosphatase regulator activity [Term] id: NeXO:9973 name: CC: | BP: polyadenylation-dependent RNA catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.7859167873093 density:0.0559252898239588 bootstrap:0.158655527 cc_score:0.0971726 bp_score:0.182982 mf_score:0.0557207 relationship: child_of NeXO:9995 ! CC: pore complex | BP: RNA 3'-end processing | MF: [Term] id: NeXO:8245 name: CC: | BP: | MF:borate transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transport of borate across a membrane against the concentration gradient." [NeXO-GO:term] namespace: NeXO comment: robustness:6.17518372692831 density:0.733333333333333 bootstrap:0.6443887 cc_score:0.0 bp_score:0.0 mf_score:0.10053 relationship: child_of NeXO:9185 ! CC: | BP: | MF: [Term] id: NeXO:8619 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.78111018912739 density:0.0514705882352941 bootstrap:0.188728378 cc_score:0.0 bp_score:0.0137646 mf_score:0.0 relationship: child_of NeXO:9521 ! CC: | BP: | MF:transcription from RNA polymerase I promoter [Term] id: NeXO:8618 name: CC: dolichyl-phosphate-mannose-protein mannosyltransferase complex | BP: ER-associated misfolded protein catabolic process | MF: def: "CC_def: A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies. | BP_def: The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95352539341537 density:1 bootstrap:0.632353561 cc_score:0.293418 bp_score:0.29436 mf_score:0.0 relationship: child_of NeXO:9170 ! CC: | BP: | MF: relationship: linked_to NeXO:5728 ! CC: | BP: protein O-linked glycosylation | MF:dolichyl-phosphate-mannose-protein mannosyltransferase activity [Term] id: NeXO:5868 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.554523005 cc_score:0.0 bp_score:0.0188855 mf_score:0.0 relationship: child_of NeXO:5869 ! CC: | BP: protein initiator methionine removal involved in protein maturation | MF:metalloaminopeptidase activity [Term] id: NeXO:9349 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.46292027258882 density:0.75 bootstrap:0.635085318 cc_score:0.0 bp_score:0.0382928 mf_score:0.0 relationship: child_of NeXO:9710 ! CC: | BP: oligosaccharide biosynthetic process | MF: [Term] id: NeXO:7376 name: CC: | BP: double-strand break repair via single-strand annealing, removal of nonhomologous ends | MF: def: "CC_def: | BP_def: During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.84474140714056 density:0.333333333333333 bootstrap:0.689048921 cc_score:0.0 bp_score:0.153493 mf_score:0.0 relationship: child_of NeXO:8109 ! CC: | BP: | MF: [Term] id: NeXO:8479 name: CC: clathrin coated vesicle membrane | BP: | MF: def: "CC_def: The lipid bilayer surrounding a clathrin-coated vesicle. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.09897035801055 density:0.156862745098039 bootstrap:0.320568666 cc_score:0.311113 bp_score:0.0201072 mf_score:0.0 relationship: child_of NeXO:9476 ! CC: coated pit | BP: | MF: [Term] id: NeXO:8478 name: CC: | BP: | MF:phosphatidylinositol-3,5-bisphosphate binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [NeXO-GO:term] namespace: NeXO comment: robustness:2.02390769686707 density:0.666666666666667 bootstrap:0.373296866 cc_score:0.0684733 bp_score:0.0 mf_score:0.154994 relationship: child_of NeXO:8819 ! CC: | BP: Golgi to endosome transport | MF: relationship: linked_to NeXO:7654 ! CC: | BP: | MF: [Term] id: NeXO:8475 name: CC: oligosaccharyltransferase complex | BP: protein N-linked glycosylation via asparagine | MF:dolichyl-diphosphooligosaccharide-protein glycotransferase activity def: "CC_def: A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. | BP_def: The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. | MF_def:Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [NeXO-GO:term] namespace: NeXO comment: robustness:3.69978735437605 density:1 bootstrap:0.75605207 cc_score:0.292474 bp_score:0.35375 mf_score:0.295112 relationship: child_of NeXO:9527 ! CC: | BP: | MF: relationship: linked_to NeXO:8358 ! CC: | BP: | MF:glucosaminyl-phosphotidylinositol O-acyltransferase activity relationship: linked_to NeXO:8760 ! CC: endoplasmic reticulum Sec complex | BP: posttranslational protein targeting to membrane, translocation | MF:P-P-bond-hydrolysis-driven protein transmembrane transporter activity relationship: linked_to NeXO:8646 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:9422 ! CC: Golgi stack | BP: | MF: [Term] id: NeXO:8474 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94260880067566 density:0.666666666666667 bootstrap:0.343909081 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8931 ! CC: | BP: | MF: [Term] id: NeXO:8477 name: CC: | BP: | MF:endopeptidase activator activity def: "CC_def: | BP_def: | MF_def:Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.672356511 cc_score:0.0 bp_score:0.0 mf_score:0.293664 relationship: child_of NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9211 ! CC: proteasome regulatory particle, base subcomplex | BP: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:8061 ! CC: proteasome storage granule | BP: | MF: [Term] id: NeXO:8476 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.862724562155929 density:0.0666666666666667 bootstrap:0.222597012 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9328 ! CC: | BP: | MF: [Term] id: NeXO:5554 name: CC: | BP: mitochondrial translational elongation | MF: def: "CC_def: | BP_def: The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.416363129 cc_score:0.0 bp_score:0.219215 mf_score:0.0 relationship: child_of NeXO:5793 ! CC: | BP: | MF: [Term] id: NeXO:8470 name: CC: Ski complex | BP: response to virus | MF:response to virus def: "CC_def: A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p. | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. | MF_def:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9955611079731 density:1 bootstrap:0.659860162 cc_score:0.437575 bp_score:0.438167 mf_score:0.4375 relationship: child_of NeXO:9317 ! CC: | BP: | MF: relationship: linked_to NeXO:8241 ! CC: cytoplasmic exosome (RNase complex) | BP: nonfunctional rRNA decay | MF: [Term] id: NeXO:8473 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93242587976257 density:1 bootstrap:0.61876756 cc_score:0.0 bp_score:0.0825099 mf_score:0.0 relationship: child_of NeXO:8970 ! CC: | BP: | MF: relationship: linked_to NeXO:7765 ! CC: | BP: | MF: relationship: linked_to NeXO:9475 ! CC: F-actin capping protein complex | BP: barbed-end actin filament capping | MF: [Term] id: NeXO:8472 name: CC: nuclear cohesin complex | BP: ubiquitin-dependent protein catabolic process via the N-end rule pathway | MF: def: "CC_def: A cohesin complex required for cohesion between sister chromatids that remain in the nucleus. | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61342393 cc_score:0.168034 bp_score:0.291933 mf_score:0.0 relationship: child_of NeXO:9548 ! CC: | BP: | MF: relationship: linked_to NeXO:8650 ! CC: condensed nuclear chromosome outer kinetochore | BP: establishment of meiotic sister chromatid cohesion | MF: [Term] id: NeXO:6402 name: CC: membrane raft | BP: | MF:FMN binding def: "CC_def: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. | BP_def: | MF_def:Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [NeXO-GO:term] namespace: NeXO comment: robustness:3.96406039335584 density:0.4 bootstrap:0.83563292 cc_score:0.114798 bp_score:0.0133303 mf_score:0.134762 relationship: child_of NeXO:6608 ! CC: | BP: | MF: [Term] id: NeXO:6403 name: CC: | BP: fructose 2,6-bisphosphate metabolic process | MF:6-phosphofructo-2-kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. | MF_def:Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.854969801 cc_score:0.0 bp_score:0.453098 mf_score:0.45408 relationship: child_of NeXO:6673 ! CC: | BP: regulation of glycolysis | MF:phosphofructokinase activity [Term] id: NeXO:6400 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.63733341911124 density:0.1 bootstrap:0.71619746 cc_score:0.0 bp_score:0.0477886 mf_score:0.0 relationship: child_of NeXO:7453 ! CC: | BP: | MF: [Term] id: NeXO:7565 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43995429889609 density:0.333333333333333 bootstrap:0.419832913 cc_score:0.0 bp_score:0.0914578 mf_score:0.0 relationship: child_of NeXO:9449 ! CC: exosome (RNase complex) | BP: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:6228 ! CC: | BP: polyadenylation-dependent snoRNA 3'-end processing | MF: [Term] id: NeXO:6406 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.760044793 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7592 ! CC: | BP: | MF: [Term] id: NeXO:6407 name: CC: | BP: fructose transport | MF:mannosidase activity def: "CC_def: | BP_def: The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. | MF_def:Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.895381891 cc_score:0.0 bp_score:0.202939 mf_score:0.128964 relationship: child_of NeXO:6408 ! CC: | BP: glucose import | MF: [Term] id: NeXO:7560 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.16282179868909 density:0.142857142857143 bootstrap:0.70154101 cc_score:0.0 bp_score:0.0935142 mf_score:0.0 relationship: child_of NeXO:8423 ! CC: | BP: | MF: [Term] id: NeXO:5718 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85660514 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6672 ! CC: | BP: | MF: [Term] id: NeXO:8185 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.16138521225151 density:0.7 bootstrap:0.46222657 cc_score:0.0 bp_score:0.0516946 mf_score:0.0 relationship: child_of NeXO:8607 ! CC: | BP: | MF: [Term] id: NeXO:5716 name: CC: | BP: response to organic cyclic compound | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06567005778254 density:0.666666666666667 bootstrap:0.856492894 cc_score:0.0 bp_score:0.166651 mf_score:0.089209 relationship: child_of NeXO:5991 ! CC: | BP: phosphate transport | MF:phosphate transmembrane transporter activity [Term] id: NeXO:8187 name: CC: | BP: ethanol catabolic process | MF:TFIID-class transcription factor binding def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.481386707 cc_score:0.0 bp_score:0.439887 mf_score:0.446829 relationship: child_of NeXO:9099 ! CC: | BP: cellular response to ethanol | MF:TFIIB-class transcription factor binding relationship: linked_to NeXO:8785 ! CC: | BP: | MF: relationship: linked_to NeXO:8730 ! CC: | BP: positive regulation of lipid catabolic process | MF: [Term] id: NeXO:8186 name: CC: | BP: | MF:cyclic-nucleotide phosphodiesterase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.217461228 cc_score:0.0 bp_score:0.0698069 mf_score:0.101244 relationship: child_of NeXO:8720 ! CC: | BP: | MF: [Term] id: NeXO:5713 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.72744125829339 density:0.333333333333333 bootstrap:0.604206845 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5792 ! CC: | BP: | MF: [Term] id: NeXO:5712 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04341819947204 density:0.333333333333333 bootstrap:0.845461 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5732 ! CC: | BP: | MF: [Term] id: NeXO:8183 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.6286958878425 density:0.935897435897436 bootstrap:0.319088211 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8184 ! CC: | BP: | MF: [Term] id: NeXO:7569 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.481666451 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8828 ! CC: | BP: | MF: [Term] id: NeXO:7765 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.27982066869275 density:0.333333333333333 bootstrap:0.33164794 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7971 ! CC: | BP: | MF: [Term] id: NeXO:7766 name: CC: | BP: nuclear pore distribution | MF: def: "CC_def: | BP_def: Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.294350178 cc_score:0.0 bp_score:0.126494 mf_score:0.0 relationship: child_of NeXO:8730 ! CC: | BP: positive regulation of lipid catabolic process | MF: [Term] id: NeXO:7760 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.8223043094963 density:0.0952380952380952 bootstrap:0.491733652 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8049 ! CC: | BP: | MF: [Term] id: NeXO:7761 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.25156514627913 density:0.333333333333333 bootstrap:0.317165533 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8030 ! CC: | BP: | MF: [Term] id: NeXO:7762 name: CC: | BP: | MF:phosphatidylinositol phospholipase C activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.295241618 cc_score:0.0 bp_score:0.0 mf_score:0.253839 relationship: child_of NeXO:8428 ! CC: | BP: regulation of cell growth | MF: [Term] id: NeXO:7763 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23690048680128 density:0.111111111111111 bootstrap:0.30812334 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8809 ! CC: | BP: | MF: [Term] id: NeXO:9586 name: CC: methyltransferase complex | BP: histone methylation | MF:histone methylation def: "CC_def: A protein complex that possesses methyltransferase activity. | BP_def: The modification of histones by addition of methyl groups. | MF_def:The modification of histones by addition of methyl groups." [NeXO-GO:term] namespace: NeXO comment: robustness:6.7773809613581 density:0.226315789473684 bootstrap:0.285397689 cc_score:0.186038 bp_score:0.171066 mf_score:0.260089 relationship: child_of NeXO:9784 ! CC: | BP: histone modification | MF:histone H3-K4 methylation [Term] id: NeXO:9308 name: CC: Elg1 RFC-like complex | BP: | MF: def: "CC_def: A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.01113877448271 density:0.8 bootstrap:0.564574729 cc_score:0.200954 bp_score:0.0398805 mf_score:0.0 relationship: child_of NeXO:9699 ! CC: | BP: negative regulation of DNA-dependent DNA replication | MF: relationship: linked_to NeXO:9156 ! CC: nuclear replisome | BP: DNA synthesis involved in DNA repair | MF: relationship: linked_to NeXO:9494 ! CC: checkpoint clamp complex | BP: mitotic cell cycle G1/S transition checkpoint | MF:exodeoxyribonuclease III activity [Term] id: NeXO:5862 name: CC: | BP: | MF:3-methyl-2-oxobutanoate hydroxymethyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89467859 cc_score:0.0 bp_score:0.0 mf_score:0.442852 relationship: child_of NeXO:6178 ! CC: | BP: | MF:pantoate-beta-alanine ligase activity [Term] id: NeXO:7768 name: CC: | BP: establishment or maintenance of actin cytoskeleton polarity | MF:phosphatidylinositol-4,5-bisphosphate binding def: "CC_def: | BP_def: Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures. | MF_def:Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [NeXO-GO:term] namespace: NeXO comment: robustness:4.85777426943981 density:0.428571428571429 bootstrap:0.565206151 cc_score:0.0 bp_score:0.352746 mf_score:0.10796 relationship: child_of NeXO:8428 ! CC: | BP: regulation of cell growth | MF: [Term] id: NeXO:7769 name: CC: | BP: proton-transporting two-sector ATPase complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.40323790404996 density:0.357142857142857 bootstrap:0.663508172 cc_score:0.0 bp_score:0.133314 mf_score:0.0 relationship: child_of NeXO:7830 ! CC: vacuolar proton-transporting V-type ATPase, V0 domain | BP: vacuolar acidification | MF: [Term] id: NeXO:9657 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.2615749508111 density:1 bootstrap:0.263722972 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9774 ! CC: | BP: regulation of protein desumoylation | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:5486 ! CC: | BP: GO:0052837 | MF:GTP cyclohydrolase activity relationship: linked_to NeXO:9212 ! CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: relationship: linked_to NeXO:6228 ! CC: | BP: polyadenylation-dependent snoRNA 3'-end processing | MF: relationship: linked_to NeXO:6057 ! CC: | BP: tetrahydrofolate biosynthetic process | MF:nicotinate-nucleotide diphosphorylase (carboxylating) activity [Term] id: NeXO:9654 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79269119557337 density:0.222222222222222 bootstrap:0.250652507 cc_score:0.0 bp_score:0.0656046 mf_score:0.0 relationship: child_of NeXO:9842 ! CC: | BP: | MF: [Term] id: NeXO:5708 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.85036383077893 density:0.166666666666667 bootstrap:0.80575593 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7379 ! CC: | BP: | MF: [Term] id: NeXO:9655 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.66232531280053 density:0.147058823529412 bootstrap:0.201624901 cc_score:0.0 bp_score:0.0548705 mf_score:0.0 relationship: child_of NeXO:9846 ! CC: | BP: | MF: [Term] id: NeXO:6745 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.62337975759122 density:0.2 bootstrap:0.57320517 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7540 ! CC: | BP: | MF: [Term] id: NeXO:6744 name: CC: | BP: second-messenger-mediated signaling | MF:diacylglycerol kinase activity def: "CC_def: | BP_def: A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell. | MF_def:Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.92937098302924 density:0.285714285714286 bootstrap:0.462633079 cc_score:0.0 bp_score:0.130498 mf_score:0.17047 relationship: child_of NeXO:7058 ! CC: | BP: | MF: [Term] id: NeXO:6747 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.3437609331672 density:0.5 bootstrap:0.739721445 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6748 ! CC: | BP: | MF: [Term] id: NeXO:6746 name: CC: | BP: | MF:thiosulfate sulfurtransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77884423 cc_score:0.0 bp_score:0.0 mf_score:0.150694 relationship: child_of NeXO:7368 ! CC: | BP: | MF: relationship: linked_to NeXO:6028 ! CC: | BP: | MF: [Term] id: NeXO:6741 name: CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [NeXO-GO:term] namespace: NeXO comment: robustness:4.91186558436433 density:0.117647058823529 bootstrap:0.48425359 cc_score:0.0 bp_score:0.068948 mf_score:0.125372 relationship: child_of NeXO:7723 ! CC: | BP: | MF: [Term] id: NeXO:6740 name: CC: | BP: acetate metabolic process | MF:aldehyde dehydrogenase (NAD) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving acetate, the anion of acetic acid. | MF_def:Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:5.5357070689702 density:0.533333333333333 bootstrap:0.77528 cc_score:0.0 bp_score:0.235554 mf_score:0.644921 relationship: child_of NeXO:6741 ! CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: NeXO:6743 name: CC: | BP: | MF:oligopeptide transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of oligopeptides from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.582268337 cc_score:0.0 bp_score:0.0 mf_score:0.166668 relationship: child_of NeXO:7644 ! CC: | BP: | MF: [Term] id: NeXO:8244 name: CC: endoplasmic reticulum palmitoyltransferase complex | BP: | MF: def: "CC_def: A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.79180658602284 density:0.128205128205128 bootstrap:0.440512212 cc_score:0.191858 bp_score:0.0942667 mf_score:0.0 relationship: child_of NeXO:9279 ! CC: | BP: | MF: [Term] id: NeXO:6749 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.388400749 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7545 ! CC: | BP: | MF: [Term] id: NeXO:6748 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.78880734933881 density:0.857142857142857 bootstrap:0.597989011 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7369 ! CC: | BP: | MF: [Term] id: NeXO:7188 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.402093109 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7856 ! CC: | BP: | MF:polynucleotide 5'-phosphatase activity [Term] id: NeXO:9659 name: CC: | BP: cytoplasmic mRNA processing body assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.46273596133635 density:1 bootstrap:0.615190825 cc_score:0.0 bp_score:0.12908 mf_score:0.0 relationship: child_of NeXO:9939 ! CC: cytoplasmic mRNA processing body | BP: mRNA catabolic process | MF: relationship: linked_to NeXO:9105 ! CC: U6 snRNP | BP: | MF: [Term] id: NeXO:8764 name: CC: translation release factor complex | BP: actin filament reorganization involved in cell cycle | MF:translation release factor activity, codon specific def: "CC_def: A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome. | BP_def: The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs. | MF_def:A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.34411071 cc_score:0.291721 bp_score:0.177827 mf_score:0.29759 relationship: child_of NeXO:9272 ! CC: | BP: | MF: [Term] id: NeXO:9301 name: CC: SWI/SNF complex | BP: nucleosome mobilization | MF:positive regulation of transcription, DNA-dependent def: "CC_def: A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. | BP_def: The movement of nucleosomes along a DNA fragment. | MF_def:Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [NeXO-GO:term] namespace: NeXO comment: robustness:11.823186236341 density:1 bootstrap:0.82718052 cc_score:0.595589 bp_score:0.423599 mf_score:0.21875 relationship: child_of NeXO:9686 ! CC: | BP: ATP-dependent chromatin remodeling | MF: [Term] id: NeXO:5897 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86684731 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6593 ! CC: | BP: | MF: [Term] id: NeXO:5808 name: CC: | BP: L-methionine biosynthetic process from S-adenosylmethionine | MF:homocysteine S-methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.849766283 cc_score:0.0 bp_score:0.441632 mf_score:0.222196 relationship: child_of NeXO:7028 ! CC: | BP: phosphatidylserine catabolic process | MF: [Term] id: NeXO:9958 name: CC: mitochondrial membrane part | BP: mitochondrion organization | MF: def: "CC_def: Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.5429420604322 density:0.0416334484896802 bootstrap:0.37322143 cc_score:0.228811 bp_score:0.216308 mf_score:0.0894613 relationship: child_of NeXO:9998 ! CC: mitochondrial part | BP: localization | MF:transporter activity [Term] id: NeXO:5803 name: CC: alpha-glucosidase II complex | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05055538590082 density:0.333333333333333 bootstrap:0.851377313 cc_score:0.229645 bp_score:0.0400819 mf_score:0.0801889 relationship: child_of NeXO:5804 ! CC: vacuolar transporter chaperone complex | BP: polyphosphate metabolic process | MF: [Term] id: NeXO:9954 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.0434325557451 density:0.00988934993084371 bootstrap:0.084253305 cc_score:0.0223077 bp_score:0.0406267 mf_score:0.043062 relationship: child_of NeXO:9976 ! CC: | BP: | MF: [Term] id: NeXO:9957 name: CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport def: "CC_def: Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. | BP_def: The directed movement of a protein from the cytoplasm to the nucleus. | MF_def:The directed movement of molecules between the nucleus and the cytoplasm." [NeXO-GO:term] namespace: NeXO comment: robustness:20.1488019730339 density:0.230204081632653 bootstrap:0.55365539 cc_score:0.311371 bp_score:0.292027 mf_score:0.364655 relationship: child_of NeXO:9995 ! CC: pore complex | BP: RNA 3'-end processing | MF: [Term] id: NeXO:5800 name: CC: | BP: glycyl-tRNA aminoacylation | MF:tryptophan synthase activity def: "CC_def: | BP_def: The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70230819 cc_score:0.0 bp_score:0.200863 mf_score:0.316272 relationship: child_of NeXO:6399 ! CC: | BP: nucleotide phosphorylation | MF:adenylate kinase activity [Term] id: NeXO:5807 name: CC: | BP: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III | MF:[pyruvate dehydrogenase (lipoamide)] phosphatase activity def: "CC_def: | BP_def: The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end. | MF_def:Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8246461 cc_score:0.0 bp_score:0.275066 mf_score:0.312914 relationship: child_of NeXO:6173 ! CC: | BP: tRNA 3'-trailer cleavage | MF: [Term] id: NeXO:5806 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94965045649142 density:0.166666666666667 bootstrap:0.89454617 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7478 ! CC: | BP: | MF: [Term] id: NeXO:5804 name: CC: vacuolar transporter chaperone complex | BP: polyphosphate metabolic process | MF: def: "CC_def: A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p. | BP_def: The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.41614534990791 density:0.666666666666667 bootstrap:0.90979242 cc_score:0.483266 bp_score:0.221084 mf_score:0.0 relationship: child_of NeXO:5957 ! CC: | BP: | MF: [Term] id: NeXO:7247 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.83145454482745 density:1 bootstrap:0.55579436 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7396 ! CC: | BP: | MF: [Term] id: NeXO:6937 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27889569657199 density:0.190476190476190 bootstrap:0.33557988 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7884 ! CC: | BP: | MF: [Term] id: NeXO:8649 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.67220192096624 density:0.666666666666667 bootstrap:0.614531216 cc_score:0.0 bp_score:0.0952717 mf_score:0.0 relationship: child_of NeXO:9804 ! CC: | BP: | MF: relationship: linked_to NeXO:8930 ! CC: | BP: establishment of mitotic sister chromatid cohesion | MF: [Term] id: NeXO:9985 name: CC: U2-type spliceosomal complex | BP: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | MF: def: "CC_def: Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. | BP_def: Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.9876156321281 density:0.23068698209035 bootstrap:0.72065753 cc_score:0.489724 bp_score:0.496671 mf_score:0.0156155 relationship: child_of NeXO:9986 ! CC: spliceosomal complex | BP: RNA splicing, via transesterification reactions | MF: [Term] id: NeXO:8129 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.9864031166323 density:1 bootstrap:0.776166459 cc_score:0.0 bp_score:0.077784 mf_score:0.0 relationship: child_of NeXO:9407 ! CC: mRNA cleavage and polyadenylation specificity factor complex | BP: termination of RNA polymerase II transcription | MF: [Term] id: NeXO:7184 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.3481646730349 density:0.121212121212121 bootstrap:0.432274238 cc_score:0.0 bp_score:0.0320828 mf_score:0.0742189 relationship: child_of NeXO:8402 ! CC: | BP: | MF: [Term] id: NeXO:6230 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.14991733824989 density:1 bootstrap:0.765888187 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6833 ! CC: | BP: | MF: [Term] id: NeXO:7185 name: CC: | BP: sister chromatid biorientation | MF: def: "CC_def: | BP_def: The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92914865 cc_score:0.0 bp_score:0.110322 mf_score:0.0 relationship: child_of NeXO:7860 ! CC: | BP: protein localization to kinetochore | MF: [Term] id: NeXO:5937 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76301527 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5938 ! CC: | BP: | MF: [Term] id: NeXO:5936 name: CC: | BP: | MF:GO:0001187 def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.864827359 cc_score:0.0 bp_score:0.0 mf_score:0.262399 relationship: child_of NeXO:6812 ! CC: RNA polymerase I transcription factor complex | BP: transcription of nuclear rRNA large RNA polymerase I transcript | MF:sequence-specific DNA binding RNA polymerase I transcription factor activity relationship: linked_to NeXO:5935 ! CC: | BP: | MF:RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: NeXO:5935 name: CC: | BP: | MF:RNA polymerase I regulatory region sequence-specific DNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [NeXO-GO:term] namespace: NeXO comment: robustness:2.79132590444414 density:0.333333333333333 bootstrap:0.831679482 cc_score:0.0 bp_score:0.0 mf_score:0.554175 relationship: child_of NeXO:6812 ! CC: RNA polymerase I transcription factor complex | BP: transcription of nuclear rRNA large RNA polymerase I transcript | MF:sequence-specific DNA binding RNA polymerase I transcription factor activity [Term] id: NeXO:5934 name: CC: RNA polymerase I upstream activating factor complex | BP: | MF:RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity def: "CC_def: A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p. | BP_def: | MF_def:Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24681068718254 density:1 bootstrap:0.83647855 cc_score:0.382438 bp_score:0.0 mf_score:0.465197 relationship: child_of NeXO:5935 ! CC: | BP: | MF:RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: NeXO:5933 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33903914258722 density:1 bootstrap:0.90656057 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6180 ! CC: | BP: | MF: [Term] id: NeXO:5932 name: CC: | BP: | MF:manganese-transporting ATPase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.28686195455863 density:1 bootstrap:0.8665662 cc_score:0.0 bp_score:0.0228424 mf_score:0.442626 relationship: child_of NeXO:7326 ! CC: | BP: | MF: [Term] id: NeXO:5931 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82105009 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6587 ! CC: | BP: | MF: [Term] id: NeXO:8885 name: CC: DNA topoisomerase complex (ATP-hydrolyzing) | BP: DNA topoisomerase (ATP-hydrolyzing) activity | MF: def: "CC_def: Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity. | BP_def: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53223613194154 density:0.666666666666667 bootstrap:0.58436116 cc_score:0.268198 bp_score:0.200492 mf_score:0.0 relationship: child_of NeXO:9466 ! CC: | BP: | MF: [Term] id: NeXO:6541 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.34283666635097 density:0.1 bootstrap:0.481731346 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6824 ! CC: | BP: | MF: [Term] id: NeXO:7362 name: CC: COMA complex | BP: attachment of spindle microtubules to kinetochore | MF: def: "CC_def: A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. | BP_def: The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06080932694489 density:1 bootstrap:0.703716071 cc_score:0.439641 bp_score:0.256252 mf_score:0.0 relationship: child_of NeXO:8649 ! CC: | BP: | MF: relationship: linked_to NeXO:9176 ! CC: | BP: | MF: relationship: linked_to NeXO:9354 ! CC: | BP: | MF: [Term] id: NeXO:8128 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.67345234659959 density:0.111111111111111 bootstrap:0.2118688 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8985 ! CC: | BP: | MF: [Term] id: NeXO:5938 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86095706922223 density:0.333333333333333 bootstrap:0.70121593 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6266 ! CC: | BP: | MF:polyamine transmembrane transporter activity [Term] id: NeXO:7816 name: CC: glycerol-3-phosphate dehydrogenase complex | BP: intracellular accumulation of glycerol | MF:fumarate reductase (NADH) activity def: "CC_def: An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. | BP_def: The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment. | MF_def:Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.304755062 cc_score:0.218821 bp_score:0.440995 mf_score:0.294911 relationship: child_of NeXO:8524 ! CC: | BP: | MF:glycerol-3-phosphate dehydrogenase [NAD+] activity [Term] id: NeXO:7817 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.18842358226289 density:0.333333333333333 bootstrap:0.150756976 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8149 ! CC: | BP: | MF: [Term] id: NeXO:7814 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.595540758 cc_score:0.0 bp_score:0.060112 mf_score:0.0 relationship: child_of NeXO:8790 ! CC: | BP: | MF: relationship: linked_to NeXO:9727 ! CC: | BP: mitotic cell cycle G2/M transition decatenation checkpoint | MF: [Term] id: NeXO:7815 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.0760825160088 density:0.6 bootstrap:0.562454016 cc_score:0.0 bp_score:0.0616223 mf_score:0.0687721 relationship: child_of NeXO:7962 ! CC: | BP: peroxisome fission | MF: [Term] id: NeXO:7812 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.06863399955281 density:0.0632411067193676 bootstrap:0.64680633 cc_score:0.0 bp_score:0.0442942 mf_score:0.0923596 relationship: child_of NeXO:8624 ! CC: | BP: | MF: [Term] id: NeXO:7813 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87512718943722 density:0.333333333333333 bootstrap:0.7119353 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8887 ! CC: | BP: | MF: [Term] id: NeXO:7810 name: CC: | BP: L-serine biosynthetic process | MF:aspartate kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. | MF_def:Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.66077736837296 density:1 bootstrap:0.74019273 cc_score:0.0 bp_score:0.298526 mf_score:0.295229 relationship: child_of NeXO:8092 ! CC: | BP: threonine metabolic process | MF:O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Term] id: NeXO:7811 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.71014823999745 density:0.166666666666667 bootstrap:0.337077915 cc_score:0.0 bp_score:0.0925017 mf_score:0.0915817 relationship: child_of NeXO:7954 ! CC: | BP: | MF: [Term] id: NeXO:7818 name: CC: | BP: activation of MAPKKK activity involved in osmosensory signaling pathway | MF:mitogen-activated protein kinase kinase kinase binding def: "CC_def: | BP_def: Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing. | MF_def:Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:3.55939772892219 density:1 bootstrap:0.69976339 cc_score:0.0 bp_score:0.301211 mf_score:0.295248 relationship: child_of NeXO:8444 ! CC: | BP: two-component signal transduction system (phosphorelay) | MF:two-component signal transduction system (phosphorelay) [Term] id: NeXO:7819 name: CC: | BP: phosphatidylserine biosynthetic process | MF:phosphatidylethanolamine N-methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.99802392414948 density:0.5 bootstrap:0.594658949 cc_score:0.0 bp_score:0.161954 mf_score:0.201068 relationship: child_of NeXO:8775 ! CC: | BP: | MF:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [Term] id: NeXO:7454 name: CC: | BP: | MF:serine-type carboxypeptidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.595312025 cc_score:0.0 bp_score:0.0 mf_score:0.222421 relationship: child_of NeXO:8197 ! CC: | BP: | MF:phosphatidylinositol deacylase activity relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:5096 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.24014047939167 density:0.0277777777777778 bootstrap:0.61687751 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5112 ! CC: | BP: arginyl-tRNA aminoacylation | MF:arginine-tRNA ligase activity [Term] id: NeXO:9980 name: CC: microtubule cytoskeleton | BP: microtubule-based process | MF: def: "CC_def: The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. | BP_def: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.4024959668204 density:0.142108328479907 bootstrap:0.51340049 cc_score:0.245125 bp_score:0.252137 mf_score:0.0341095 relationship: child_of NeXO:10025 ! CC: cytoskeleton | BP: mitotic cell cycle | MF:cell cycle [Term] id: NeXO:8969 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.36258778666799 density:1 bootstrap:0.67077762 cc_score:0.0 bp_score:0.0592519 mf_score:0.0 relationship: child_of NeXO:9352 ! CC: nuclear origin of replication recognition complex | BP: pre-replicative complex assembly | MF: [Term] id: NeXO:8968 name: CC: | BP: replication fork arrest | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.58543719209426 density:1 bootstrap:0.71003935 cc_score:0.0 bp_score:0.227717 mf_score:0.0 relationship: child_of NeXO:9549 ! CC: replication fork protection complex | BP: replication fork protection | MF: relationship: linked_to NeXO:8969 ! CC: | BP: | MF: relationship: linked_to NeXO:9308 ! CC: Elg1 RFC-like complex | BP: | MF: [Term] id: NeXO:9784 name: CC: | BP: histone modification | MF:histone H3-K4 methylation def: "CC_def: | BP_def: The covalent alteration of one or more amino acid residues within a histone protein. | MF_def:The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [NeXO-GO:term] namespace: NeXO comment: robustness:6.7727931374353 density:0.0980392156862745 bootstrap:0.293866146 cc_score:0.0642276 bp_score:0.13144 mf_score:0.140563 relationship: child_of NeXO:9982 ! CC: chromatin remodeling complex | BP: nucleosome organization | MF: [Term] id: NeXO:9014 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.52103812469008 density:0.111111111111111 bootstrap:0.39137231 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9490 ! CC: | BP: | MF: [Term] id: NeXO:9785 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.03711358603624 density:0.0259740259740260 bootstrap:0.140387835 cc_score:0.0 bp_score:0.0275482 mf_score:0.0210803 relationship: child_of NeXO:9869 ! CC: | BP: | MF: [Term] id: NeXO:5065 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88751892 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5384 ! CC: | BP: uracil catabolic process | MF: [Term] id: NeXO:9378 name: CC: | BP: ergosterol metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.4401360151085 density:0.478947368421053 bootstrap:0.6421772 cc_score:0.0 bp_score:0.335024 mf_score:0.0893233 relationship: child_of NeXO:9962 ! CC: | BP: modification-dependent protein catabolic process | MF: [Term] id: NeXO:5067 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86563117 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6774 ! CC: | BP: intracellular copper ion transport | MF:copper chaperone activity [Term] id: NeXO:5066 name: CC: | BP: glycerol transport | MF:glycerol transport def: "CC_def: | BP_def: The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. | MF_def:The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73535175 cc_score:0.0 bp_score:0.131649 mf_score:0.145989 relationship: child_of NeXO:5070 ! CC: | BP: | MF: [Term] id: NeXO:5061 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71765811 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5074 ! CC: | BP: | MF:2-dehydropantoate 2-reductase activity [Term] id: NeXO:7568 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.455711917 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7923 ! CC: | BP: | MF: relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:8259 ! CC: | BP: | MF: [Term] id: NeXO:5063 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7034438 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5071 ! CC: | BP: | MF: [Term] id: NeXO:5062 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79387825 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5063 ! CC: | BP: | MF: [Term] id: NeXO:9371 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.396934752 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9741 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:9370 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.31286134896691 density:0.131578947368421 bootstrap:0.233254111 cc_score:0.0 bp_score:0.0345998 mf_score:0.0 relationship: child_of NeXO:9690 ! CC: | BP: | MF: [Term] id: NeXO:9373 name: CC: | BP: positive regulation of actin filament bundle assembly | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.4116045898366 density:1 bootstrap:0.64285875 cc_score:0.0 bp_score:0.140946 mf_score:0.0 relationship: child_of NeXO:9757 ! CC: | BP: actin cortical patch localization | MF: relationship: linked_to NeXO:8604 ! CC: | BP: | MF: relationship: linked_to NeXO:9055 ! CC: Arp2/3 protein complex | BP: regulation of actin filament polymerization | MF: relationship: linked_to NeXO:7717 ! CC: | BP: actin filament-based movement | MF: relationship: linked_to NeXO:8407 ! CC: | BP: | MF: [Term] id: NeXO:9372 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.05776355228106 density:1 bootstrap:0.51228007 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9534 ! CC: | BP: | MF: relationship: linked_to NeXO:9685 ! CC: | BP: | MF: [Term] id: NeXO:5069 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8806146 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6452 ! CC: | BP: | MF: [Term] id: NeXO:9374 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76408125221323 density:0.111111111111111 bootstrap:0.191632179 cc_score:0.0 bp_score:0.0122045 mf_score:0.0631677 relationship: child_of NeXO:9870 ! CC: | BP: glucose catabolic process | MF: [Term] id: NeXO:9377 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64964904264439 density:0.090909090909091 bootstrap:0.151111814 cc_score:0.0 bp_score:0.0637119 mf_score:0.0752108 relationship: child_of NeXO:9746 ! CC: | BP: | MF: [Term] id: NeXO:9376 name: CC: | BP: regulation of fungal-type cell wall organization | MF: def: "CC_def: | BP_def: Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.66825377537506 density:0.4 bootstrap:0.4855889 cc_score:0.0 bp_score:0.173154 mf_score:0.0700801 relationship: child_of NeXO:9913 ! CC: | BP: | MF: relationship: linked_to NeXO:9841 ! CC: | BP: response to acid | MF: [Term] id: NeXO:7962 name: CC: | BP: peroxisome fission | MF: def: "CC_def: | BP_def: The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.58617262716861 density:0.571428571428571 bootstrap:0.724759054 cc_score:0.0487653 bp_score:0.319834 mf_score:0.0 relationship: child_of NeXO:8451 ! CC: | BP: | MF: [Term] id: NeXO:7963 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.812636855 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8684 ! CC: | BP: | MF: relationship: linked_to NeXO:9631 ! CC: | BP: | MF: [Term] id: NeXO:7960 name: CC: | BP: hydroxymethylglutaryl-CoA reductase (NADPH) activity | MF:hydroxymethylglutaryl-CoA reductase (NADPH) activity def: "CC_def: | BP_def: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. | MF_def:Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:1.68588695023426 density:0.333333333333333 bootstrap:0.57548759 cc_score:0.0 bp_score:0.566022 mf_score:0.567574 relationship: child_of NeXO:8713 ! CC: | BP: cholesterol biosynthetic process | MF: relationship: linked_to NeXO:8910 ! CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity [Term] id: NeXO:7961 name: CC: | BP: | MF:diphosphomevalonate decarboxylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.65056053136116 density:0.666666666666667 bootstrap:0.64024824 cc_score:0.0 bp_score:0.0 mf_score:0.269952 relationship: child_of NeXO:8900 ! CC: | BP: | MF:acid-ammonia (or amide) ligase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity [Term] id: NeXO:7967 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89412433 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9251 ! CC: | BP: | MF: [Term] id: NeXO:7964 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.05693755872006 density:0.104575163398693 bootstrap:0.19521371 cc_score:0.0 bp_score:0.0296533 mf_score:0.0607829 relationship: child_of NeXO:9110 ! CC: | BP: | MF: [Term] id: NeXO:7965 name: CC: | BP: choline transport | MF:choline transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. | MF_def:Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [NeXO-GO:term] namespace: NeXO comment: robustness:0.868465592100264 density:0.0666666666666667 bootstrap:0.225569428 cc_score:0.0 bp_score:0.145727 mf_score:0.144017 relationship: child_of NeXO:8899 ! CC: | BP: | MF:CDP-choline pathway [Term] id: NeXO:9177 name: CC: RES complex | BP: snRNA capping | MF: def: "CC_def: A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p. | BP_def: The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.52711227521158 density:1 bootstrap:0.80318883 cc_score:0.250401 bp_score:0.147876 mf_score:0.0 relationship: child_of NeXO:9532 ! CC: | BP: | MF: [Term] id: NeXO:9176 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9423805092258 density:0.2 bootstrap:0.455868613 cc_score:0.0 bp_score:0.0905167 mf_score:0.0 relationship: child_of NeXO:9868 ! CC: chromatin silencing complex | BP: progressive alteration of chromatin involved in cell aging | MF:nucleosome binding relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:7968 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.63591421552998 density:0.666666666666667 bootstrap:0.633192095 cc_score:0.0 bp_score:0.0985561 mf_score:0.0 relationship: child_of NeXO:8769 ! CC: mitochondrial respiratory chain complex III | BP: mitochondrial electron transport, ubiquinol to cytochrome c | MF: [Term] id: NeXO:9174 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.90312098292373 density:0.373626373626374 bootstrap:0.66419593 cc_score:0.0 bp_score:0.0650668 mf_score:0.0 relationship: child_of NeXO:9547 ! CC: | BP: | MF: [Term] id: NeXO:9173 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.885259723324 density:0.866666666666667 bootstrap:0.64229668 cc_score:0.0627453 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9619 ! CC: | BP: | MF: [Term] id: NeXO:9172 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.9227741552792 density:0.4 bootstrap:0.555311433 cc_score:0.0 bp_score:0.0139871 mf_score:0.0 relationship: child_of NeXO:9512 ! CC: | BP: vacuole inheritance | MF: [Term] id: NeXO:9170 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10378910999248 density:0.666666666666667 bootstrap:0.40334562 cc_score:0.0 bp_score:0.0485611 mf_score:0.0 relationship: child_of NeXO:9709 ! CC: | BP: | MF: relationship: linked_to NeXO:8910 ! CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:8960 name: CC: | BP: regulation of translational initiation in response to stress | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64737712395856 density:1 bootstrap:0.44968449 cc_score:0.0 bp_score:0.441652 mf_score:0.0 relationship: child_of NeXO:9191 ! CC: | BP: | MF: [Term] id: NeXO:8967 name: CC: | BP: | MF:Ras GTPase binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [NeXO-GO:term] namespace: NeXO comment: robustness:2.5780112407004 density:0.3 bootstrap:0.498577189 cc_score:0.0 bp_score:0.0841545 mf_score:0.111901 relationship: child_of NeXO:9511 ! CC: | BP: | MF:Rho GTPase activator activity [Term] id: NeXO:9573 name: CC: mitochondrial large ribosomal subunit | BP: | MF: def: "CC_def: The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:20.5388651321908 density:0.308467741935484 bootstrap:0.67892011 cc_score:0.471361 bp_score:0.0313132 mf_score:0.0 relationship: child_of NeXO:9609 ! CC: mitochondrial ribosome | BP: regulation of pH | MF: [Term] id: NeXO:9572 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.7207948755864 density:0.0191919191919192 bootstrap:0.292242359 cc_score:0.0 bp_score:0.0348003 mf_score:0.0115035 relationship: child_of NeXO:9771 ! CC: | BP: | MF: [Term] id: NeXO:6259 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35793788155503 density:1 bootstrap:0.92126923 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6934 ! CC: | BP: | MF: [Term] id: NeXO:6258 name: CC: | BP: | MF:hydrogen-exporting ATPase activity, phosphorylative mechanism def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.864076712 cc_score:0.0 bp_score:0.0 mf_score:0.220417 relationship: child_of NeXO:7060 ! CC: | BP: | MF: [Term] id: NeXO:9576 name: CC: DNA replication preinitiation complex | BP: double-strand break repair via break-induced replication | MF: def: "CC_def: A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. | BP_def: The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.1748797245334 density:0.259740259740260 bootstrap:0.44420068 cc_score:0.32252 bp_score:0.356765 mf_score:0.064055 relationship: child_of NeXO:9951 ! CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding [Term] id: NeXO:9575 name: CC: small ribosomal subunit | BP: mitochondrial translation | MF: def: "CC_def: The smaller of the two subunits of a ribosome. | BP_def: The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.3628432470567 density:0.107098765432099 bootstrap:0.411133404 cc_score:0.140411 bp_score:0.170637 mf_score:0.0919779 relationship: child_of NeXO:9781 ! CC: mitochondrial matrix | BP: oxidative phosphorylation | MF:monovalent inorganic cation transmembrane transporter activity [Term] id: NeXO:9574 name: CC: mitochondrial small ribosomal subunit | BP: | MF: def: "CC_def: The smaller of the two subunits of a mitochondrial ribosome. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:24.5727668535844 density:0.501075268817204 bootstrap:0.82347268 cc_score:0.527024 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9575 ! CC: small ribosomal subunit | BP: mitochondrial translation | MF: [Term] id: NeXO:6253 name: CC: | BP: adenine biosynthetic process | MF:phosphoribosylglycinamide formyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. | MF_def:Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [NeXO-GO:term] namespace: NeXO comment: robustness:2.18677211482331 density:1 bootstrap:0.7923716 cc_score:0.0 bp_score:0.246064 mf_score:0.442852 relationship: child_of NeXO:6944 ! CC: | BP: adenine metabolic process | MF:adenine deaminase activity [Term] id: NeXO:6252 name: CC: | BP: | MF:amino acid kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.77336155153442 density:0.333333333333333 bootstrap:0.636756873 cc_score:0.0 bp_score:0.0589672 mf_score:0.328031 relationship: child_of NeXO:6936 ! CC: | BP: | MF:phosphotransferase activity, carboxyl group as acceptor [Term] id: NeXO:6251 name: CC: | BP: proline biosynthetic process | MF:glutamate 5-kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.596529155 cc_score:0.0 bp_score:0.355672 mf_score:0.890346 relationship: child_of NeXO:6252 ! CC: | BP: | MF:amino acid kinase activity relationship: linked_to NeXO:7443 ! CC: | BP: | MF:glutamate-5-semialdehyde dehydrogenase activity [Term] id: NeXO:9578 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.91434689453891 density:0.0251315020455874 bootstrap:0.234391154 cc_score:0.0 bp_score:0.0361967 mf_score:0.0127285 relationship: child_of NeXO:9854 ! CC: | BP: | MF: [Term] id: NeXO:6257 name: CC: | BP: | MF:glycolipid 6-alpha-mannosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.816643946 cc_score:0.0 bp_score:0.0 mf_score:0.298677 relationship: child_of NeXO:7026 ! CC: Golgi cis cisterna | BP: secretory granule organization | MF:ARF guanyl-nucleotide exchange factor activity [Term] id: NeXO:6254 name: CC: meiotic spindle | BP: | MF: def: "CC_def: A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.818075401 cc_score:0.219249 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7703 ! CC: septin cytoskeleton | BP: | MF: relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding [Term] id: NeXO:5393 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90858519 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6732 ! CC: | BP: pyrimidine-containing compound transmembrane transport | MF:uracil:cation symporter activity [Term] id: NeXO:5392 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92810250985668 density:0.333333333333333 bootstrap:0.752730138 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7182 ! CC: | BP: sphingolipid catabolic process | MF:ceramidase activity [Term] id: NeXO:5391 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88128955 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6074 ! CC: | BP: | MF: [Term] id: NeXO:5390 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94048471157241 density:0.333333333333333 bootstrap:0.762429191 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6316 ! CC: | BP: regulation of transcription from RNA polymerase II promoter in response to iron | MF: [Term] id: NeXO:5397 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8711918 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6998 ! CC: | BP: | MF: [Term] id: NeXO:5396 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.862071263 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6227 ! CC: | BP: | MF: [Term] id: NeXO:5395 name: CC: | BP: | MF:sodium:inorganic phosphate symporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85841318 cc_score:0.0 bp_score:0.0 mf_score:0.318953 relationship: child_of NeXO:5991 ! CC: | BP: phosphate transport | MF:phosphate transmembrane transporter activity [Term] id: NeXO:5394 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81992526 cc_score:0.0 bp_score:0.0361711 mf_score:0.0 relationship: child_of NeXO:5488 ! CC: | BP: | MF:acylglycerone-phosphate reductase activity [Term] id: NeXO:5399 name: CC: | BP: negative regulation of microtubule polymerization or depolymerization | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.851340187 cc_score:0.0 bp_score:0.100206 mf_score:0.0 relationship: child_of NeXO:6076 ! CC: | BP: | MF: [Term] id: NeXO:5398 name: CC: | BP: | MF:ammonia-lyase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.21774390251626 density:0.666666666666667 bootstrap:0.94357384 cc_score:0.0 bp_score:0.0 mf_score:0.108619 relationship: child_of NeXO:6581 ! CC: | BP: | MF: [Term] id: NeXO:9718 name: CC: Golgi-associated vesicle membrane | BP: retrograde vesicle-mediated transport, Golgi to ER | MF: def: "CC_def: The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. | BP_def: The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.65190780263078 density:0.515151515151515 bootstrap:0.462384499 cc_score:0.152841 bp_score:0.134569 mf_score:0.0 relationship: child_of NeXO:9845 ! CC: COPI-coated vesicle | BP: ER to Golgi vesicle-mediated transport | MF: [Term] id: NeXO:8016 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.709044828 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8929 ! CC: | BP: | MF: relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter [Term] id: NeXO:9713 name: CC: | BP: positive regulation of meiotic cell cycle | MF:protein tyrosine/serine/threonine phosphatase activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. | MF_def:Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58680612 cc_score:0.0 bp_score:0.442374 mf_score:0.12354 relationship: child_of NeXO:9897 ! CC: | BP: regulation of ubiquitin-protein ligase activity | MF:amino acid binding relationship: linked_to NeXO:9340 ! CC: | BP: | MF: relationship: linked_to NeXO:9352 ! CC: nuclear origin of replication recognition complex | BP: pre-replicative complex assembly | MF: relationship: linked_to NeXO:8505 ! CC: | BP: meiotic anaphase II | MF: relationship: linked_to NeXO:9607 ! CC: | BP: activation of anaphase-promoting complex activity involved in meiotic cell cycle | MF:anaphase-promoting complex binding relationship: linked_to NeXO:5185 ! CC: | BP: | MF: relationship: linked_to NeXO:5707 ! CC: | BP: | MF: relationship: linked_to NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: relationship: linked_to NeXO:5819 ! CC: | BP: | MF: relationship: linked_to NeXO:7747 ! CC: | BP: mitotic anaphase | MF: relationship: linked_to NeXO:5470 ! CC: | BP: positive regulation of transcription involved in G2/M-phase of mitotic cell cycle | MF: relationship: linked_to NeXO:9164 ! CC: | BP: rDNA condensation | MF:rDNA binding relationship: linked_to NeXO:9213 ! CC: | BP: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:cyclin-dependent protein kinase inhibitor activity relationship: linked_to NeXO:7904 ! CC: | BP: | MF:ubiquitin-protein ligase regulator activity relationship: linked_to NeXO:9147 ! CC: spindle midzone | BP: mitotic spindle stabilization | MF: [Term] id: NeXO:9712 name: CC: | BP: sulfur amino acid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.93717759933385 density:0.117408906882591 bootstrap:0.240669713 cc_score:0.0 bp_score:0.126683 mf_score:0.019761 relationship: child_of NeXO:9871 ! CC: | BP: | MF: [Term] id: NeXO:9711 name: CC: actin filament | BP: negative regulation of actin filament polymerization | MF: def: "CC_def: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.38107708522192 density:0.666666666666667 bootstrap:0.366608367 cc_score:0.142395 bp_score:0.14773 mf_score:0.0 relationship: child_of NeXO:9862 ! CC: | BP: chitin biosynthetic process | MF: relationship: linked_to NeXO:9215 ! CC: | BP: | MF: [Term] id: NeXO:9710 name: CC: | BP: oligosaccharide biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.4387982399468 density:0.813186813186813 bootstrap:0.588336818 cc_score:0.0 bp_score:0.112639 mf_score:0.0620365 relationship: child_of NeXO:9795 ! CC: | BP: | MF: [Term] id: NeXO:9717 name: CC: | BP: lagging strand elongation | MF: def: "CC_def: | BP_def: The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.50742756629072 density:0.242647058823529 bootstrap:0.239617447 cc_score:0.0542512 bp_score:0.207448 mf_score:0.054503 relationship: child_of NeXO:9951 ! CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding [Term] id: NeXO:8015 name: CC: | BP: | MF:phosphoribosylaminoimidazolecarboxamide formyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.238819048 cc_score:0.0 bp_score:0.0 mf_score:0.204519 relationship: child_of NeXO:9101 ! CC: | BP: | MF: [Term] id: NeXO:9715 name: CC: | BP: double-strand break repair via homologous recombination | MF:DNA metabolic process def: "CC_def: | BP_def: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. | MF_def:Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [NeXO-GO:term] namespace: NeXO comment: robustness:19.9158595544432 density:0.515151515151515 bootstrap:0.70626546 cc_score:0.0 bp_score:0.159401 mf_score:0.151201 relationship: child_of NeXO:9951 ! CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding [Term] id: NeXO:7368 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.85428918176741 density:0.333333333333333 bootstrap:0.69619996 cc_score:0.0 bp_score:0.0 mf_score:0.0654787 relationship: child_of NeXO:9462 ! CC: | BP: tRNA wobble uridine modification | MF: [Term] id: NeXO:7369 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.4431687522916 density:0.916666666666667 bootstrap:0.573074011 cc_score:0.0 bp_score:0.0188304 mf_score:0.0 relationship: child_of NeXO:7477 ! CC: | BP: tRNA wobble position uridine thiolation | MF:URM1 activating enzyme activity [Term] id: NeXO:8014 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.55250065081819 density:0.138888888888889 bootstrap:0.374499469 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9058 ! CC: | BP: | MF: [Term] id: NeXO:8888 name: CC: Pwp2p-containing subcomplex of 90S preribosome | BP: | MF: def: "CC_def: A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.26678683101714 density:0.535714285714286 bootstrap:0.53710122 cc_score:0.311354 bp_score:0.0436567 mf_score:0.0 relationship: child_of NeXO:9259 ! CC: t-UTP complex | BP: positive regulation of transcription from RNA polymerase I promoter | MF: [Term] id: NeXO:8889 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.61768146631043 density:0.0282258064516129 bootstrap:0.284889888 cc_score:0.0 bp_score:0.0206846 mf_score:0.0 relationship: child_of NeXO:9477 ! CC: | BP: | MF: [Term] id: NeXO:8884 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.38819496344137 density:0.333333333333333 bootstrap:0.222790333 cc_score:0.0 bp_score:0.011152 mf_score:0.06839 relationship: child_of NeXO:9590 ! CC: | BP: | MF: [Term] id: NeXO:7361 name: CC: nuclear MIS12/MIND type complex | BP: | MF: def: "CC_def: A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10491610458077 density:1 bootstrap:0.7341612 cc_score:0.438668 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8324 ! CC: | BP: | MF: relationship: linked_to NeXO:9354 ! CC: | BP: | MF: [Term] id: NeXO:8886 name: CC: | BP: maltose transport | MF:maltose:hydrogen symporter activity def: "CC_def: | BP_def: The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49331584 cc_score:0.0 bp_score:0.16257 mf_score:0.202369 relationship: child_of NeXO:9353 ! CC: | BP: | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: relationship: linked_to NeXO:8778 ! CC: | BP: | MF: [Term] id: NeXO:8887 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79194140274848 density:0.266666666666667 bootstrap:0.46008425 cc_score:0.0 bp_score:0.0134749 mf_score:0.0 relationship: child_of NeXO:9440 ! CC: | BP: regulation of pseudohyphal growth | MF: [Term] id: NeXO:7364 name: CC: | BP: GO:2001125 | MF:ornithine decarboxylase inhibitor activity def: "CC_def: | BP_def: | MF_def:The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.44211948 cc_score:0.0 bp_score:0.441348 mf_score:0.442111 relationship: child_of NeXO:8046 ! CC: | BP: | MF: [Term] id: NeXO:7365 name: CC: | BP: | MF:U6 snRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87733993 cc_score:0.0 bp_score:0.0 mf_score:0.221472 relationship: child_of NeXO:8193 ! CC: | BP: | MF: relationship: linked_to NeXO:9105 ! CC: U6 snRNP | BP: | MF: [Term] id: NeXO:8882 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.03847023036081 density:0.166666666666667 bootstrap:0.253791663 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9236 ! CC: | BP: | MF: relationship: linked_to NeXO:9270 ! CC: | BP: | MF: [Term] id: NeXO:8883 name: CC: microtubule plus end | BP: nuclear migration along microtubule | MF:microtubule plus-end binding def: "CC_def: The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. | BP_def: The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. | MF_def:Interacting selectively and non-covalently with the plus end of a microtubule." [NeXO-GO:term] namespace: NeXO comment: robustness:9.39446001884286 density:1 bootstrap:0.69634116 cc_score:0.115483 bp_score:0.166495 mf_score:0.103927 relationship: child_of NeXO:9431 ! CC: dynein complex | BP: nuclear migration | MF:motor activity relationship: linked_to NeXO:9866 ! CC: | BP: mitotic cell cycle G2/M transition checkpoint | MF: [Term] id: NeXO:6698 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.518001774 cc_score:0.0 bp_score:0.0 mf_score:0.0104947 relationship: child_of NeXO:7042 ! CC: | BP: fatty acid elongation | MF:fatty acid elongase activity [Term] id: NeXO:8011 name: CC: multivesicular body membrane | BP: multivesicular body membrane disassembly | MF: def: "CC_def: The lipid bilayer surrounding a multivesicular body. | BP_def: The controlled breakdown of the membranes of multivesicular bodies. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72537374 cc_score:0.223688 bp_score:0.438229 mf_score:0.0 relationship: child_of NeXO:8857 ! CC: autophagic vacuole | BP: C-terminal protein amino acid modification | MF:Atg8 ligase activity relationship: linked_to NeXO:7658 ! CC: | BP: C-terminal protein lipidation | MF:APG12 activating enzyme activity [Term] id: NeXO:6829 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.95629744862766 density:0.4 bootstrap:0.832363232 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7841 ! CC: | BP: | MF: [Term] id: NeXO:7457 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.425835438 cc_score:0.0 bp_score:0.0106061 mf_score:0.0 relationship: child_of NeXO:8193 ! CC: | BP: | MF: [Term] id: NeXO:9877 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29413159185573 density:0.0152309612983770 bootstrap:0.081407289 cc_score:0.0 bp_score:0.0282025 mf_score:0.0197341 relationship: child_of NeXO:9923 ! CC: | BP: | MF: [Term] id: NeXO:5584 name: CC: | BP: NAD biosynthetic process | MF:nicotinamide-nucleotide adenylyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. | MF_def:Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.08122276639428 density:0.666666666666667 bootstrap:0.86520523 cc_score:0.0 bp_score:0.127047 mf_score:0.572734 relationship: child_of NeXO:5597 ! CC: | BP: | MF:nicotinate-nucleotide adenylyltransferase activity [Term] id: NeXO:9006 name: CC: | BP: | MF:cAMP-dependent protein kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [NeXO-GO:term] namespace: NeXO comment: robustness:5.5804430858688 density:0.5 bootstrap:0.464676805 cc_score:0.0 bp_score:0.0444639 mf_score:0.311399 relationship: child_of NeXO:9412 ! CC: | BP: cAMP-mediated signaling | MF: [Term] id: NeXO:7020 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.44729225 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9573 ! CC: mitochondrial large ribosomal subunit | BP: | MF: relationship: linked_to NeXO:9067 ! CC: | BP: | MF: [Term] id: NeXO:9003 name: CC: | BP: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78695529 cc_score:0.0 bp_score:0.296097 mf_score:0.0586353 relationship: child_of NeXO:9626 ! CC: | BP: positive regulation of transcription initiation from RNA polymerase II promoter | MF:TFIID-class binding transcription factor activity relationship: linked_to NeXO:9672 ! CC: | BP: | MF: relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: [Term] id: NeXO:9002 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.8477478951215 density:1 bootstrap:0.646024101 cc_score:0.0 bp_score:0.0109979 mf_score:0.0 relationship: child_of NeXO:9464 ! CC: DNA-directed RNA polymerase III complex | BP: tRNA transcription from RNA polymerase III promoter | MF: [Term] id: NeXO:7025 name: CC: | BP: | MF:[cytochrome c]-lysine N-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [NeXO-GO:term] namespace: NeXO comment: robustness:3.52643096998002 density:0.5 bootstrap:0.50436981 cc_score:0.0 bp_score:0.0835337 mf_score:0.214603 relationship: child_of NeXO:7195 ! CC: | BP: | MF: [Term] id: NeXO:5488 name: CC: | BP: | MF:acylglycerone-phosphate reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75650329 cc_score:0.0 bp_score:0.0 mf_score:0.250566 relationship: child_of NeXO:6222 ! CC: | BP: | MF:aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Term] id: NeXO:5487 name: CC: | BP: regulation of macroautophagy | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of macroautophagy. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.773934352 cc_score:0.0 bp_score:0.179566 mf_score:0.0 relationship: child_of NeXO:6052 ! CC: cyclin-dependent protein kinase holoenzyme complex | BP: regulation of autophagy | MF:protein kinase binding [Term] id: NeXO:5486 name: CC: | BP: GO:0052837 | MF:GTP cyclohydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77221117 cc_score:0.0 bp_score:0.250787 mf_score:0.165884 relationship: child_of NeXO:6057 ! CC: | BP: tetrahydrofolate biosynthetic process | MF:nicotinate-nucleotide diphosphorylase (carboxylating) activity [Term] id: NeXO:7029 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.58938697238094 density:0.333333333333333 bootstrap:0.715696367 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8328 ! CC: | BP: | MF: [Term] id: NeXO:5484 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86554414139367 density:0.166666666666667 bootstrap:0.81903094 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6465 ! CC: | BP: | MF: [Term] id: NeXO:5483 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79242752493298 density:0.166666666666667 bootstrap:0.756088196 cc_score:0.0 bp_score:0.0925907 mf_score:0.0 relationship: child_of NeXO:6597 ! CC: | BP: | MF: [Term] id: NeXO:5482 name: CC: | BP: | MF:nucleotide transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.85770846458222 density:0.333333333333333 bootstrap:0.87170741 cc_score:0.0 bp_score:0.0 mf_score:0.138874 relationship: child_of NeXO:6372 ! CC: | BP: | MF:magnesium ion transmembrane transporter activity [Term] id: NeXO:5481 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.63229176370298 density:1 bootstrap:0.87606202 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6125 ! CC: transcription factor TFIIIC complex | BP: | MF: [Term] id: NeXO:7453 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.13903081141917 density:0.0476190476190476 bootstrap:0.430405377 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8171 ! CC: | BP: | MF: [Term] id: NeXO:9397 name: CC: | BP: mitochondrial membrane organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.24220154754315 density:0.0306122448979592 bootstrap:0.170428425 cc_score:0.0657285 bp_score:0.146983 mf_score:0.0615668 relationship: child_of NeXO:9798 ! CC: mitochondrial inner membrane | BP: | MF: [Term] id: NeXO:9396 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.25767964114781 density:0.0952380952380952 bootstrap:0.234222271 cc_score:0.0 bp_score:0.0816881 mf_score:0.0 relationship: child_of NeXO:9721 ! CC: | BP: intracellular protein transmembrane transport | MF:protein transmembrane transporter activity [Term] id: NeXO:9395 name: CC: anaphase-promoting complex | BP: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: def: "CC_def: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.5501576017526 density:0.897435897435897 bootstrap:0.77258364 cc_score:0.624408 bp_score:0.606987 mf_score:0.0991066 relationship: child_of NeXO:9731 ! CC: nuclear ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:9393 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.28674993 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9501 ! CC: | BP: | MF: [Term] id: NeXO:5629 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78546282 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6106 ! CC: | BP: positive regulation of protein oligomerization | MF: [Term] id: NeXO:9391 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43838516852896 density:0.0389610389610390 bootstrap:0.110217221 cc_score:0.0 bp_score:0.0481848 mf_score:0.0 relationship: child_of NeXO:9765 ! CC: | BP: | MF: [Term] id: NeXO:9390 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51852378319194 density:0.0212121212121212 bootstrap:0.213612812 cc_score:0.0 bp_score:0.0315812 mf_score:0.0 relationship: child_of NeXO:9802 ! CC: | BP: | MF: [Term] id: NeXO:5245 name: CC: | BP: triglyceride lipase activity | MF:triglyceride lipase activity def: "CC_def: | BP_def: Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. | MF_def:Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93212508 cc_score:0.0 bp_score:0.109375 mf_score:0.110746 relationship: child_of NeXO:5813 ! CC: | BP: | MF: [Term] id: NeXO:5244 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91481989 cc_score:0.0 bp_score:0.0 mf_score:0.0714909 relationship: child_of NeXO:6763 ! CC: | BP: | MF: [Term] id: NeXO:5247 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74358129 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5460 ! CC: | BP: | MF: [Term] id: NeXO:5628 name: CC: | BP: positive regulation of transcription from RNA polymerase II promoter by glucose | MF:SUMO-specific protease activity def: "CC_def: | BP_def: Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. | MF_def:Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.535654626 cc_score:0.0 bp_score:0.439114 mf_score:0.294015 relationship: child_of NeXO:5818 ! CC: | BP: | MF: [Term] id: NeXO:5241 name: CC: RNA polymerase I core factor complex | BP: transcription initiation from RNA polymerase I promoter | MF:RNA polymerase I core promoter sequence-specific DNA binding def: "CC_def: A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. | BP_def: Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.40965777822664 density:1 bootstrap:0.9621274 cc_score:0.469938 bp_score:0.439754 mf_score:0.903322 relationship: child_of NeXO:5935 ! CC: | BP: | MF:RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: NeXO:9399 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.55522557892279 density:0.152046783625731 bootstrap:0.238955237 cc_score:0.0723581 bp_score:0.0822469 mf_score:0.0 relationship: child_of NeXO:9656 ! CC: | BP: | MF: [Term] id: NeXO:5242 name: CC: | BP: cellular response to methylmercury | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.400867011 cc_score:0.0 bp_score:0.109918 mf_score:0.0 relationship: child_of NeXO:5446 ! CC: | BP: | MF: [Term] id: NeXO:9832 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.48957002095525 density:0.0738636363636364 bootstrap:0.121641143 cc_score:0.0 bp_score:0.0874274 mf_score:0.0 relationship: child_of NeXO:9943 ! CC: | BP: | MF:translation factor activity, nucleic acid binding [Term] id: NeXO:5711 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.00088438923781 density:0.666666666666667 bootstrap:0.8206755 cc_score:0.0 bp_score:0.0476959 mf_score:0.0 relationship: child_of NeXO:7024 ! CC: | BP: | MF:xenobiotic-transporting ATPase activity relationship: linked_to NeXO:9057 ! CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Term] id: NeXO:7596 name: CC: | BP: | MF:S-methyl-5-thioribose-1-phosphate isomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7866243434744 density:0.333333333333333 bootstrap:0.64631697 cc_score:0.0 bp_score:0.0891257 mf_score:0.316947 relationship: child_of NeXO:7914 ! CC: | BP: | MF: [Term] id: NeXO:9830 name: CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation def: "CC_def: A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. | BP_def: The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. | MF_def:The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [NeXO-GO:term] namespace: NeXO comment: robustness:10.7119675568269 density:0.964285714285714 bootstrap:0.71883893 cc_score:0.642324 bp_score:0.287794 mf_score:0.144301 relationship: child_of NeXO:10013 ! CC: chromosome | BP: chromatin organization | MF:DNA binding relationship: linked_to NeXO:9700 ! CC: pre-replicative complex | BP: progressive alteration of chromatin involved in replicative cell aging | MF: [Term] id: NeXO:7026 name: CC: Golgi cis cisterna | BP: secretory granule organization | MF:ARF guanyl-nucleotide exchange factor activity def: "CC_def: The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. | MF_def:Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:1.81974339921611 density:0.333333333333333 bootstrap:0.670500908 cc_score:0.290859 bp_score:0.313205 mf_score:0.211549 relationship: child_of NeXO:7502 ! CC: Golgi cisterna | BP: regulation of ARF protein signal transduction | MF: [Term] id: NeXO:7931 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.11220774393303 density:0.533333333333333 bootstrap:0.661194705 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8400 ! CC: | BP: | MF: [Term] id: NeXO:5624 name: CC: extrinsic to endoplasmic reticulum membrane | BP: | MF: def: "CC_def: Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8311819 cc_score:0.175591 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7560 ! CC: | BP: | MF: [Term] id: NeXO:9001 name: CC: | BP: activation of Ras GTPase activity | MF: def: "CC_def: | BP_def: Any process that initiates the activity of an inactive GTPase of the Ras superfamily through the replacement of GDP by GTP. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60512654405754 density:0.166666666666667 bootstrap:0.606328249 cc_score:0.0 bp_score:0.164667 mf_score:0.0 relationship: child_of NeXO:9522 ! CC: | BP: | MF: relationship: linked_to NeXO:7618 ! CC: | BP: | MF: [Term] id: NeXO:9836 name: CC: filamentous actin | BP: tubulin complex biogenesis | MF: def: "CC_def: A two-stranded helical polymer of the protein actin. | BP_def: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.77992211733739 density:0.428571428571429 bootstrap:0.342214118 cc_score:0.104536 bp_score:0.32475 mf_score:0.0 relationship: child_of NeXO:9990 ! CC: | BP: | MF: relationship: linked_to NeXO:9668 ! CC: | BP: microtubule depolymerization | MF: [Term] id: NeXO:7024 name: CC: | BP: | MF:xenobiotic-transporting ATPase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:4.48497479077867 density:0.833333333333333 bootstrap:0.70863309 cc_score:0.0 bp_score:0.0877132 mf_score:0.285942 relationship: child_of NeXO:7025 ! CC: | BP: | MF:[cytochrome c]-lysine N-methyltransferase activity [Term] id: NeXO:7281 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90558681097126 density:1 bootstrap:0.46630051 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7728 ! CC: | BP: re-entry into mitotic cell cycle after pheromone arrest | MF: [Term] id: NeXO:9837 name: CC: cis-Golgi network | BP: Golgi to vacuole transport | MF:Ras guanyl-nucleotide exchange factor activity def: "CC_def: The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. | BP_def: The directed movement of substances from the Golgi to the vacuole. | MF_def:Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:12.8390628353689 density:0.201079622132254 bootstrap:0.309623256 cc_score:0.144967 bp_score:0.182696 mf_score:0.125911 relationship: child_of NeXO:9937 ! CC: | BP: vacuole organization | MF: [Term] id: NeXO:7799 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.24782054417086 density:0.3 bootstrap:0.79131034 cc_score:0.0 bp_score:0.0116876 mf_score:0.0745554 relationship: child_of NeXO:8270 ! CC: | BP: SRP-dependent cotranslational protein targeting to membrane | MF:signal sequence binding [Term] id: NeXO:7280 name: CC: Hrd1p ubiquitin ligase ERAD-L complex | BP: | MF: def: "CC_def: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.92679820667134 density:0.666666666666667 bootstrap:0.78065384 cc_score:0.259493 bp_score:0.0589289 mf_score:0.0 relationship: child_of NeXO:8419 ! CC: | BP: | MF: relationship: linked_to NeXO:8910 ! CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity [Term] id: NeXO:6475 name: CC: extrinsic to mitochondrial outer membrane | BP: peroxidase activity | MF:phospholipid-hydroperoxide glutathione peroxidase activity def: "CC_def: Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region. | BP_def: Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. | MF_def:Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [NeXO-GO:term] namespace: NeXO comment: robustness:3.05957797455931 density:0.666666666666667 bootstrap:0.85309224 cc_score:0.182107 bp_score:0.139821 mf_score:0.427727 relationship: child_of NeXO:6476 ! CC: | BP: proline transport | MF:glutathione peroxidase activity [Term] id: NeXO:7791 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.463204258 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7837 ! CC: | BP: | MF: [Term] id: NeXO:7790 name: CC: | BP: aromatic amino acid transport | MF:aromatic amino acid transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [NeXO-GO:term] namespace: NeXO comment: robustness:3.0357644698878 density:0.190476190476190 bootstrap:0.595501919 cc_score:0.0 bp_score:0.206644 mf_score:0.156955 relationship: child_of NeXO:8629 ! CC: | BP: amino acid transmembrane transport | MF:amino acid transmembrane transporter activity [Term] id: NeXO:7792 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68399313 cc_score:0.0 bp_score:0.0245293 mf_score:0.0 relationship: child_of NeXO:8206 ! CC: | BP: | MF:biotin synthase activity relationship: linked_to NeXO:8012 ! CC: | BP: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase | MF:deoxyhypusine synthase activity [Term] id: NeXO:5485 name: CC: | BP: uracil transport | MF:uridine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of uridine, uracil riboside, from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.8738739607511 density:0.166666666666667 bootstrap:0.82636136 cc_score:0.0 bp_score:0.236205 mf_score:0.236141 relationship: child_of NeXO:6732 ! CC: | BP: pyrimidine-containing compound transmembrane transport | MF:uracil:cation symporter activity [Term] id: NeXO:7286 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.43078128328215 density:1 bootstrap:0.54215715 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8129 ! CC: | BP: | MF: [Term] id: NeXO:7694 name: CC: | BP: | MF:adenylate cyclase binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the enzyme adenylate cyclase." [NeXO-GO:term] namespace: NeXO comment: robustness:1.90393771748382 density:0.333333333333333 bootstrap:0.73398053 cc_score:0.0 bp_score:0.0 mf_score:0.313431 relationship: child_of NeXO:8432 ! CC: actin filament bundle | BP: actin filament depolymerization | MF:actin filament binding [Term] id: NeXO:7028 name: CC: | BP: phosphatidylserine catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10661720335209 density:0.133333333333333 bootstrap:0.596737495 cc_score:0.0 bp_score:0.140648 mf_score:0.0 relationship: child_of NeXO:7480 ! CC: | BP: | MF: [Term] id: NeXO:6593 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.43919233360283 density:0.2 bootstrap:0.71889119 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6993 ! CC: | BP: | MF: [Term] id: NeXO:7937 name: CC: | BP: pyrimidine base metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73338203286752 density:0.111111111111111 bootstrap:0.241549552 cc_score:0.0 bp_score:0.146017 mf_score:0.0509733 relationship: child_of NeXO:8797 ! CC: | BP: | MF: [Term] id: NeXO:9872 name: CC: peroxisome | BP: | MF: def: "CC_def: A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.93042590468087 density:0.0344500632111252 bootstrap:0.124428088 cc_score:0.128942 bp_score:0.0780698 mf_score:0.0 relationship: child_of NeXO:9960 ! CC: | BP: | MF: [Term] id: NeXO:7158 name: CC: | BP: negative regulation of invasive growth in response to glucose limitation | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28341163958666 density:1 bootstrap:0.8639533 cc_score:0.0 bp_score:0.452176 mf_score:0.0393635 relationship: child_of NeXO:8594 ! CC: | BP: regulation of invasive growth in response to glucose limitation | MF: relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity [Term] id: NeXO:7157 name: CC: | BP: inositol phosphate biosynthetic process | MF:inositol pentakisphosphate 2-kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. | MF_def:Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.10600718472664 density:1 bootstrap:0.7349225 cc_score:0.0 bp_score:0.148173 mf_score:0.437825 relationship: child_of NeXO:7303 ! CC: | BP: | MF: [Term] id: NeXO:7155 name: CC: | BP: borate transport | MF:inorganic anion exchanger activity def: "CC_def: | BP_def: The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.93823604758871 density:1 bootstrap:0.622494014 cc_score:0.0 bp_score:0.220684 mf_score:0.439869 relationship: child_of NeXO:7674 ! CC: | BP: | MF:borate efflux transmembrane transporter activity [Term] id: NeXO:7154 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87894738 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7948 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:7153 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35124296400478 density:0.5 bootstrap:0.743035564 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7495 ! CC: | BP: | MF: [Term] id: NeXO:7152 name: CC: | BP: | MF:porin activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [NeXO-GO:term] namespace: NeXO comment: robustness:2.08796830693991 density:1 bootstrap:0.72238655 cc_score:0.0 bp_score:0.0104422 mf_score:0.228122 relationship: child_of NeXO:7969 ! CC: mitochondrial outer membrane translocase complex | BP: outer mitochondrial membrane organization | MF: relationship: linked_to NeXO:7196 ! CC: | BP: | MF: [Term] id: NeXO:7151 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.87512297639571 density:0.163636363636364 bootstrap:0.471590772 cc_score:0.0 bp_score:0.0896574 mf_score:0.0763514 relationship: child_of NeXO:8220 ! CC: | BP: | MF: [Term] id: NeXO:7150 name: CC: | BP: N-acylphosphatidylethanolamine metabolic process | MF:NAPE-specific phospholipase D activity def: "CC_def: | BP_def: The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. | MF_def:Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.25169557531939 density:1 bootstrap:0.76166439 cc_score:0.0 bp_score:0.223252 mf_score:0.176716 relationship: child_of NeXO:7172 ! CC: | BP: N-acylethanolamine metabolic process | MF: [Term] id: NeXO:6991 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09786818620447 density:0.0727272727272727 bootstrap:0.382767038 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7210 ! CC: | BP: | MF: [Term] id: NeXO:9009 name: CC: | BP: heteroduplex formation | MF:recombinase activity def: "CC_def: | BP_def: The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. | MF_def:Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:6.69399321567226 density:1 bootstrap:0.74247447 cc_score:0.0 bp_score:0.316297 mf_score:0.28967 relationship: child_of NeXO:9495 ! CC: | BP: negative regulation of transposition, RNA-mediated | MF: relationship: linked_to NeXO:9460 ! CC: | BP: gene conversion at mating-type locus, DNA double-strand break processing | MF:endodeoxyribonuclease activity [Term] id: NeXO:7938 name: CC: | BP: regulation of phosphate transport | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43791165710821 density:0.333333333333333 bootstrap:0.418642653 cc_score:0.0 bp_score:0.319183 mf_score:0.0 relationship: child_of NeXO:8869 ! CC: | BP: inorganic anion transport | MF: [Term] id: NeXO:7690 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.645644446 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8720 ! CC: | BP: | MF: [Term] id: NeXO:9008 name: CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity def: "CC_def: A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage. | BP_def: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. | MF_def:Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [NeXO-GO:term] namespace: NeXO comment: robustness:4.9865882415697 density:1 bootstrap:0.68670717 cc_score:0.437638 bp_score:0.255998 mf_score:0.361375 relationship: child_of NeXO:9460 ! CC: | BP: gene conversion at mating-type locus, DNA double-strand break processing | MF:endodeoxyribonuclease activity relationship: linked_to NeXO:9589 ! CC: | BP: non-recombinational repair | MF:double-stranded telomeric DNA binding [Term] id: NeXO:7289 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85068135 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8109 ! CC: | BP: | MF: [Term] id: NeXO:7691 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.987145276609704 density:0.166666666666667 bootstrap:0.229324995 cc_score:0.0 bp_score:0.0750119 mf_score:0.0 relationship: child_of NeXO:7965 ! CC: | BP: choline transport | MF:choline transmembrane transporter activity [Term] id: NeXO:9105 name: CC: U6 snRNP | BP: | MF: def: "CC_def: A ribonucleoprotein complex that contains small nuclear RNA U6. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.161605894509 density:1 bootstrap:0.81471013 cc_score:0.684275 bp_score:0.0821971 mf_score:0.0 relationship: child_of NeXO:9829 ! CC: U4/U6 x U5 tri-snRNP complex | BP: | MF: [Term] id: NeXO:8068 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20418767667845 density:0.333333333333333 bootstrap:0.293607687 cc_score:0.0 bp_score:0.035592 mf_score:0.0 relationship: child_of NeXO:8673 ! CC: | BP: termination of RNA polymerase III transcription | MF: [Term] id: NeXO:8069 name: CC: | BP: | MF:L-proline transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:3.68299850312684 density:1 bootstrap:0.74920603 cc_score:0.0 bp_score:0.0 mf_score:0.150002 relationship: child_of NeXO:8629 ! CC: | BP: amino acid transmembrane transport | MF:amino acid transmembrane transporter activity relationship: linked_to NeXO:8628 ! CC: | BP: | MF: relationship: linked_to NeXO:7005 ! CC: | BP: tryptophan transport | MF:L-tryptophan transmembrane transporter activity [Term] id: NeXO:8067 name: CC: Rad17 RFC-like complex | BP: isopentenyl diphosphate biosynthetic process, mevalonate pathway | MF:DNA clamp loader activity def: "CC_def: A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. | BP_def: The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [NeXO-GO:term] namespace: NeXO comment: robustness:5.04757956612478 density:0.7 bootstrap:0.680057155 cc_score:0.327533 bp_score:0.118052 mf_score:0.441181 relationship: child_of NeXO:9307 ! CC: | BP: | MF: [Term] id: NeXO:8064 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.30521671850753 density:1 bootstrap:0.282284546 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8383 ! CC: | BP: | MF: [Term] id: NeXO:8065 name: CC: Mpp10 complex | BP: | MF: def: "CC_def: A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.678250457 cc_score:0.220993 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8888 ! CC: Pwp2p-containing subcomplex of 90S preribosome | BP: | MF: relationship: linked_to NeXO:9524 ! CC: | BP: | MF: relationship: linked_to NeXO:8383 ! CC: | BP: | MF: [Term] id: NeXO:8062 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.804146994192943 density:0.0222222222222222 bootstrap:0.283546939 cc_score:0.0 bp_score:0.0730164 mf_score:0.0991438 relationship: child_of NeXO:8527 ! CC: | BP: | MF: [Term] id: NeXO:8063 name: CC: Mon1-Ccz1 complex | BP: | MF: def: "CC_def: A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95627140031446 density:1 bootstrap:0.634132568 cc_score:0.293019 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8847 ! CC: AP-type membrane coat adaptor complex | BP: | MF: [Term] id: NeXO:8060 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06568553075088 density:1 bootstrap:0.70705022 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8094 ! CC: | BP: | MF: [Term] id: NeXO:8061 name: CC: proteasome storage granule | BP: | MF: def: "CC_def: A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.45127403753146 density:1 bootstrap:0.68960749 cc_score:0.175101 bp_score:0.0491336 mf_score:0.0 relationship: child_of NeXO:9309 ! CC: proteasome core complex, beta-subunit complex | BP: endopeptidase activity | MF: relationship: linked_to NeXO:9212 ! CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: [Term] id: NeXO:6521 name: CC: | BP: negative regulation of transcription elongation from RNA polymerase II promoter | MF:glycine dehydrogenase (decarboxylating) activity def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. | MF_def:Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:1.63250640855603 density:0.166666666666667 bootstrap:0.627189875 cc_score:0.0 bp_score:0.206123 mf_score:0.118679 relationship: child_of NeXO:6914 ! CC: | BP: | MF: [Term] id: NeXO:7484 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.57765019592657 density:1 bootstrap:0.412423381 cc_score:0.0 bp_score:0.0128067 mf_score:0.0 relationship: child_of NeXO:9209 ! CC: Set1C/COMPASS complex | BP: histone H3-K4 methylation | MF:histone methyltransferase activity (H3-K4 specific) relationship: linked_to NeXO:7232 ! CC: | BP: | MF: [Term] id: NeXO:7487 name: CC: actin cap | BP: axial cellular bud site selection | MF:Rho GTPase binding def: "CC_def: Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae. | BP_def: The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell. | MF_def:Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [NeXO-GO:term] namespace: NeXO comment: robustness:2.28998323079322 density:1 bootstrap:0.86893332 cc_score:0.195377 bp_score:0.126195 mf_score:0.590742 relationship: child_of NeXO:8967 ! CC: | BP: | MF:Ras GTPase binding relationship: linked_to NeXO:9789 ! CC: | BP: regulation of exit from mitosis | MF:histone serine kinase activity relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding [Term] id: NeXO:6522 name: CC: GID complex | BP: negative regulation of gluconeogenesis | MF: def: "CC_def: A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.68263945128958 density:0.666666666666667 bootstrap:0.85297567 cc_score:0.487553 bp_score:0.522545 mf_score:0.0 relationship: child_of NeXO:8440 ! CC: | BP: negative regulation of cellular carbohydrate metabolic process | MF: [Term] id: NeXO:6525 name: CC: | BP: ADP biosynthetic process | MF:dolichyl-phosphate beta-D-mannosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate. | MF_def:Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.49279450398477 density:0.0666666666666667 bootstrap:0.66646149 cc_score:0.0 bp_score:0.132727 mf_score:0.188465 relationship: child_of NeXO:8062 ! CC: | BP: | MF: [Term] id: NeXO:8269 name: CC: | BP: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.205329529 cc_score:0.0 bp_score:0.101986 mf_score:0.0 relationship: child_of NeXO:9247 ! CC: | BP: | MF: [Term] id: NeXO:6527 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77283726 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8174 ! CC: | BP: | MF: [Term] id: NeXO:6526 name: CC: | BP: positive regulation of mitochondrial translation | MF:translation regulator activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. | MF_def:Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:2.74027574443526 density:0.333333333333333 bootstrap:0.80153673 cc_score:0.0 bp_score:0.169466 mf_score:0.169569 relationship: child_of NeXO:7850 ! CC: | BP: regulation of mitochondrial translation | MF: [Term] id: NeXO:5656 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9036902 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7048 ! CC: | BP: 1,6-beta-glucan biosynthetic process | MF: [Term] id: NeXO:5249 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84295464 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5468 ! CC: | BP: | MF: [Term] id: NeXO:8266 name: CC: MutLbeta complex | BP: chiasma assembly | MF:DNA insertion or deletion binding def: "CC_def: A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1. | BP_def: The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. | MF_def:Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [NeXO-GO:term] namespace: NeXO comment: robustness:3.49068733103899 density:0.333333333333333 bootstrap:0.549166468 cc_score:0.289555 bp_score:0.270465 mf_score:0.280636 relationship: child_of NeXO:9266 ! CC: mismatch repair complex | BP: meiotic mismatch repair | MF:mismatched DNA binding [Term] id: NeXO:8267 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.903435200151366 density:0.0219780219780220 bootstrap:0.209636059 cc_score:0.0 bp_score:0.0226672 mf_score:0.0 relationship: child_of NeXO:9031 ! CC: | BP: | MF: [Term] id: NeXO:7489 name: CC: vacuolar lumen | BP: positive regulation of ubiquitin-dependent endocytosis | MF: def: "CC_def: The volume enclosed within the vacuolar membrane. | BP_def: Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.629430273 cc_score:0.155374 bp_score:0.193953 mf_score:0.099055 relationship: child_of NeXO:8652 ! CC: | BP: | MF: [Term] id: NeXO:5653 name: CC: | BP: | MF:phosphatidylinositol transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.534707875 cc_score:0.0 bp_score:0.0 mf_score:0.149256 relationship: child_of NeXO:6088 ! CC: | BP: sodium ion transmembrane transport | MF:sodium ion transmembrane transport [Term] id: NeXO:8262 name: CC: MBF transcription complex | BP: GO:0090419 | MF: def: "CC_def: A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.44965693056021 density:0.5 bootstrap:0.397016269 cc_score:0.282869 bp_score:0.165343 mf_score:0.0 relationship: child_of NeXO:8695 ! CC: | BP: | MF: [Term] id: NeXO:5651 name: CC: | BP: UDP-N-acetylglucosamine biosynthetic process | MF:phosphoribosyl-AMP cyclohydrolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. | MF_def:Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.461453139 cc_score:0.0 bp_score:0.162081 mf_score:0.316702 relationship: child_of NeXO:6176 ! CC: | BP: | MF:histidinol dehydrogenase activity [Term] id: NeXO:7839 name: CC: | BP: DNA duplex unwinding | MF:single-stranded DNA-dependent ATPase activity def: "CC_def: | BP_def: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [NeXO-GO:term] namespace: NeXO comment: robustness:3.16173744696496 density:0.666666666666667 bootstrap:0.91101294 cc_score:0.0 bp_score:0.13585 mf_score:0.2586 relationship: child_of NeXO:8554 ! CC: MCM complex | BP: | MF: [Term] id: NeXO:8660 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.46081675183239 density:0.533333333333333 bootstrap:0.50343238 cc_score:0.0 bp_score:0.0399582 mf_score:0.0 relationship: child_of NeXO:9104 ! CC: | BP: | MF:histone binding [Term] id: NeXO:8661 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.51699051213093 density:1 bootstrap:0.56345978 cc_score:0.0 bp_score:0.0663268 mf_score:0.0998053 relationship: child_of NeXO:8958 ! CC: | BP: | MF:protein complex scaffold relationship: linked_to NeXO:7566 ! CC: | BP: | MF: relationship: linked_to NeXO:6468 ! CC: | BP: | MF: relationship: linked_to NeXO:9626 ! CC: | BP: positive regulation of transcription initiation from RNA polymerase II promoter | MF:TFIID-class binding transcription factor activity [Term] id: NeXO:8662 name: CC: | BP: regulation of cell shape during vegetative growth phase | MF: def: "CC_def: | BP_def: Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45279037983791 density:0.333333333333333 bootstrap:0.427351247 cc_score:0.0 bp_score:0.231015 mf_score:0.0 relationship: child_of NeXO:9111 ! CC: | BP: positive regulation of transcription from RNA polymerase III promoter | MF: relationship: linked_to NeXO:8583 ! CC: | BP: | MF: [Term] id: NeXO:8664 name: CC: COPI vesicle coat | BP: | MF: def: "CC_def: One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.7853254636783 density:0.8 bootstrap:0.75249595 cc_score:0.496776 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9159 ! CC: COPI coated vesicle membrane | BP: | MF: relationship: linked_to NeXO:9694 ! CC: | BP: | MF: [Term] id: NeXO:7363 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77055622 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8456 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:7072 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.400494854 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8528 ! CC: | BP: | MF: [Term] id: NeXO:8668 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.88511359963382 density:1 bootstrap:0.588839452 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: [Term] id: NeXO:5246 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.851358073 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6004 ! CC: | BP: | MF: [Term] id: NeXO:5710 name: CC: | BP: | MF:sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.649526201 cc_score:0.0 bp_score:0.0560138 mf_score:0.197199 relationship: child_of NeXO:6757 ! CC: | BP: mitochondrial alanyl-tRNA aminoacylation | MF:AMP biosynthetic process relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:8898 name: CC: THO complex part of transcription export complex | BP: | MF: def: "CC_def: The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.42804487 cc_score:0.177789 bp_score:0.0375871 mf_score:0.0 relationship: child_of NeXO:9087 ! CC: | BP: | MF: [Term] id: NeXO:8408 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7612446171219 density:0.333333333333333 bootstrap:0.331111491 cc_score:0.0 bp_score:0.0326785 mf_score:0.0 relationship: child_of NeXO:9164 ! CC: | BP: rDNA condensation | MF:rDNA binding [Term] id: NeXO:5243 name: CC: | BP: | MF:AT DNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84701711 cc_score:0.0 bp_score:0.0 mf_score:0.218961 relationship: child_of NeXO:5441 ! CC: | BP: | MF: [Term] id: NeXO:8400 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.60411241932836 density:0.571428571428571 bootstrap:0.549571226 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9724 ! CC: | BP: | MF: [Term] id: NeXO:8402 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.58197416410706 density:0.0555555555555556 bootstrap:0.262539808 cc_score:0.0 bp_score:0.0260977 mf_score:0.0403431 relationship: child_of NeXO:9300 ! CC: | BP: | MF: [Term] id: NeXO:8403 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.04839597206967 density:0.166666666666667 bootstrap:0.258666351 cc_score:0.0 bp_score:0.0660769 mf_score:0.0 relationship: child_of NeXO:9299 ! CC: | BP: | MF: [Term] id: NeXO:8404 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.4831935181778 density:0.218181818181818 bootstrap:0.265424852 cc_score:0.0 bp_score:0.0333625 mf_score:0.0 relationship: child_of NeXO:9343 ! CC: | BP: | MF: [Term] id: NeXO:8406 name: CC: | BP: | MF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [NeXO-GO:term] namespace: NeXO comment: robustness:1.18424886389712 density:0.0357142857142857 bootstrap:0.512782754 cc_score:0.0 bp_score:0.083468 mf_score:0.147986 relationship: child_of NeXO:9104 ! CC: | BP: | MF:histone binding [Term] id: NeXO:8407 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.85012457486198 density:0.666666666666667 bootstrap:0.69152066 cc_score:0.0 bp_score:0.0470702 mf_score:0.0574889 relationship: child_of NeXO:9130 ! CC: | BP: | MF: [Term] id: NeXO:7571 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.34814952517825 density:1 bootstrap:0.78989915 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7886 ! CC: | BP: | MF: relationship: linked_to NeXO:9864 ! CC: DNA helicase complex | BP: vesicle transport along actin filament | MF:3'-5' DNA helicase activity [Term] id: NeXO:7570 name: CC: | BP: protein delipidation | MF: def: "CC_def: | BP_def: The breakage of covalent bonds to detach lipid groups from a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.63103022903764 density:0.166666666666667 bootstrap:0.626056126 cc_score:0.0 bp_score:0.250114 mf_score:0.0 relationship: child_of NeXO:8451 ! CC: | BP: | MF: [Term] id: NeXO:5728 name: CC: | BP: protein O-linked glycosylation | MF:dolichyl-phosphate-mannose-protein mannosyltransferase activity def: "CC_def: | BP_def: A protein glycosylation process in which a sugar unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. | MF_def:Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.863616897384 density:0.333333333333333 bootstrap:0.87531572 cc_score:0.0 bp_score:0.199658 mf_score:0.453539 relationship: child_of NeXO:5737 ! CC: | BP: isopropylmalate transport | MF:isopropylmalate transmembrane transporter activity [Term] id: NeXO:5729 name: CC: | BP: mitochondrial mRNA catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.815589192 cc_score:0.0 bp_score:0.445014 mf_score:0.0 relationship: child_of NeXO:6433 ! CC: | BP: mitochondrial RNA catabolic process | MF: [Term] id: NeXO:7575 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.95687876111286 density:0.0523809523809524 bootstrap:0.339226399 cc_score:0.0 bp_score:0.0196674 mf_score:0.0 relationship: child_of NeXO:8624 ! CC: | BP: | MF: [Term] id: NeXO:6418 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92525785480871 density:0.333333333333333 bootstrap:0.750510673 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7100 ! CC: | BP: | MF: [Term] id: NeXO:7576 name: CC: | BP: | MF:succinate dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:7.8734193009231 density:0.444444444444444 bootstrap:0.673966769 cc_score:0.0 bp_score:0.0258457 mf_score:0.283023 relationship: child_of NeXO:8126 ! CC: | BP: | MF: [Term] id: NeXO:5722 name: CC: | BP: inosine metabolic process | MF:nucleotidase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. | MF_def:Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.68573633826405 density:0.333333333333333 bootstrap:0.57538477 cc_score:0.0 bp_score:0.205 mf_score:0.163064 relationship: child_of NeXO:5794 ! CC: | BP: nicotinic acid riboside biosynthetic process | MF: [Term] id: NeXO:6414 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.572402019 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7009 ! CC: | BP: | MF:COPII adaptor activity [Term] id: NeXO:6417 name: CC: | BP: removal of superoxide radicals | MF:thioredoxin-disulfide reductase activity def: "CC_def: | BP_def: Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). | MF_def:Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [NeXO-GO:term] namespace: NeXO comment: robustness:1.67318109412637 density:0.166666666666667 bootstrap:0.6588327 cc_score:0.0 bp_score:0.227311 mf_score:0.46303 relationship: child_of NeXO:6758 ! CC: | BP: | MF:oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: NeXO:5721 name: CC: extrinsic to nuclear outer membrane | BP: nuclear membrane fusion involved in karyogamy | MF: def: "CC_def: Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region. | BP_def: The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06020525317943 density:0.666666666666667 bootstrap:0.85344208 cc_score:0.315454 bp_score:0.316943 mf_score:0.0525794 relationship: child_of NeXO:6803 ! CC: | BP: organelle membrane fusion | MF: [Term] id: NeXO:5726 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.50753558534527 density:0.0476190476190476 bootstrap:0.75394886 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6688 ! CC: | BP: | MF: [Term] id: NeXO:5727 name: CC: | BP: plasma membrane lactate transport | MF:secondary active monocarboxylate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of lactate across a plasma membrane. | MF_def:Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:1.53368035377864 density:0.0476190476190476 bootstrap:0.780326674 cc_score:0.0 bp_score:0.113394 mf_score:0.114183 relationship: child_of NeXO:6236 ! CC: | BP: | MF: [Term] id: NeXO:6413 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.579174163 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7508 ! CC: nucleus-vacuole junction | BP: nucleus-vacuole junction assembly | MF: [Term] id: NeXO:5725 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82316366 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6696 ! CC: | BP: fructose metabolic process | MF:fructose-2,6-bisphosphate 2-phosphatase activity [Term] id: NeXO:7777 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02390930144649 density:0.138888888888889 bootstrap:0.235451562 cc_score:0.0 bp_score:0.0220558 mf_score:0.0852865 relationship: child_of NeXO:8425 ! CC: | BP: | MF: [Term] id: NeXO:7776 name: CC: | BP: | MF:TFIIH-class transcription factor binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [NeXO-GO:term] namespace: NeXO comment: robustness:5.857395731628 density:0.666666666666667 bootstrap:0.655314407 cc_score:0.0 bp_score:0.0 mf_score:0.115188 relationship: child_of NeXO:8170 ! CC: | BP: | MF:RNA polymerase II transcription factor recruiting transcription factor activity [Term] id: NeXO:7775 name: CC: | BP: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA | MF:methionyl-tRNA formyltransferase activity def: "CC_def: | BP_def: The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). | MF_def:Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.10855644308147 density:1 bootstrap:0.73670278 cc_score:0.0 bp_score:0.448887 mf_score:0.29484 relationship: child_of NeXO:8084 ! CC: | BP: charged-tRNA amino acid modification | MF: [Term] id: NeXO:7774 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.704672599 cc_score:0.0 bp_score:0.0808633 mf_score:0.0 relationship: child_of NeXO:8716 ! CC: | BP: | MF: relationship: linked_to NeXO:7957 ! CC: | BP: | MF:tRNA (cytosine) methyltransferase activity [Term] id: NeXO:7773 name: CC: | BP: cullin deneddylation | MF: def: "CC_def: | BP_def: The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.36918381122207 density:1 bootstrap:0.89980783 cc_score:0.0 bp_score:0.65591 mf_score:0.0 relationship: child_of NeXO:8412 ! CC: signalosome | BP: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion | MF: [Term] id: NeXO:7772 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.513983026 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8716 ! CC: | BP: | MF: relationship: linked_to NeXO:8778 ! CC: | BP: | MF: [Term] id: NeXO:7771 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.4385969697652 density:0.166666666666667 bootstrap:0.487043253 cc_score:0.0 bp_score:0.0809735 mf_score:0.0 relationship: child_of NeXO:8532 ! CC: | BP: regulation of DNA-dependent DNA replication initiation | MF:protein kinase activator activity relationship: linked_to NeXO:9214 ! CC: | BP: | MF: [Term] id: NeXO:7770 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.60639229272576 density:0.666666666666667 bootstrap:0.61908817 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8165 ! CC: ESCRT III complex | BP: intralumenal vesicle formation | MF: relationship: linked_to NeXO:6441 ! CC: ESCRT II complex | BP: negative regulation of transcription from RNA polymerase II promoter by glucose | MF: [Term] id: NeXO:7779 name: CC: | BP: base-excision repair | MF:DNA-(apurinic or apyrimidinic site) lyase activity def: "CC_def: | BP_def: In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. | MF_def:Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:6.31742010670255 density:0.9 bootstrap:0.76726167 cc_score:0.0 bp_score:0.218794 mf_score:0.65296 relationship: child_of NeXO:8035 ! CC: | BP: | MF:DNA N-glycosylase activity [Term] id: NeXO:7778 name: CC: | BP: mitochondrial tRNA wobble uridine modification | MF: def: "CC_def: | BP_def: The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.342183719 cc_score:0.0 bp_score:0.232655 mf_score:0.0 relationship: child_of NeXO:8543 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:6730 name: CC: | BP: | MF:ketol-acid reductoisomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.80974502974778 density:0.333333333333333 bootstrap:0.66315317 cc_score:0.0 bp_score:0.0 mf_score:0.268704 relationship: child_of NeXO:6946 ! CC: | BP: leucine biosynthetic process | MF: [Term] id: NeXO:6731 name: CC: | BP: | MF:phosphogluconate dehydrogenase (decarboxylating) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.69814527346953 density:1 bootstrap:0.7553811 cc_score:0.0 bp_score:0.0 mf_score:0.219311 relationship: child_of NeXO:6745 ! CC: | BP: | MF: [Term] id: NeXO:8316 name: CC: | BP: leucine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.91901765540952 density:0.190476190476190 bootstrap:0.237960547 cc_score:0.0 bp_score:0.128587 mf_score:0.0 relationship: child_of NeXO:9042 ! CC: | BP: branched chain family amino acid biosynthetic process | MF: [Term] id: NeXO:8317 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.56123637073379 density:0.305555555555556 bootstrap:0.45004851 cc_score:0.0 bp_score:0.0451972 mf_score:0.0 relationship: child_of NeXO:9151 ! CC: | BP: mitotic chromosome condensation | MF: [Term] id: NeXO:6734 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.17330783254036 density:0.178571428571429 bootstrap:0.53775721 cc_score:0.0 bp_score:0.0248721 mf_score:0.0909564 relationship: child_of NeXO:7582 ! CC: | BP: | MF: [Term] id: NeXO:6735 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62073947446542 density:0.1 bootstrap:0.701754076 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8980 ! CC: | BP: | MF: [Term] id: NeXO:8312 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.40430037231489 density:0.166666666666667 bootstrap:0.464097545 cc_score:0.0 bp_score:0.0524403 mf_score:0.0 relationship: child_of NeXO:9284 ! CC: | BP: protein deacetylation | MF:histone deacetylase activity relationship: linked_to NeXO:9616 ! CC: | BP: regulation of transcription termination, DNA-dependent | MF: [Term] id: NeXO:6738 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.86686463960156 density:0.2 bootstrap:0.68454523 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8179 ! CC: | BP: endosome transport via multivesicular body sorting pathway | MF: [Term] id: NeXO:6739 name: CC: Golgi trans cisterna | BP: | MF:oxysterol binding def: "CC_def: The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. | BP_def: | MF_def:Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.322918986 cc_score:0.315684 bp_score:0.0 mf_score:0.219797 relationship: child_of NeXO:7148 ! CC: | BP: | MF:sterol binding [Term] id: NeXO:7701 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01057600573814 density:1 bootstrap:0.66982729 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9216 ! CC: | BP: | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:9223 ! CC: | BP: | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: [Term] id: NeXO:5836 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.98979724158985 density:1 bootstrap:0.656053861 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6179 ! CC: | BP: | MF:oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: NeXO:5837 name: CC: tRNA (m1A) methyltransferase complex | BP: | MF:tRNA (adenine-N1-)-methyltransferase activity def: "CC_def: A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.40549286020309 density:1 bootstrap:0.95880434 cc_score:0.887966 bp_score:0.0221098 mf_score:0.878186 relationship: child_of NeXO:7799 ! CC: | BP: | MF: [Term] id: NeXO:5834 name: CC: | BP: mitochondrial respiratory chain complex III biogenesis | MF: def: "CC_def: | BP_def: The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91395994807683 density:0.666666666666667 bootstrap:0.77382026 cc_score:0.0 bp_score:0.167595 mf_score:0.0 relationship: child_of NeXO:5835 ! CC: | BP: | MF:L-serine ammonia-lyase activity [Term] id: NeXO:8087 name: CC: Sec61 translocon complex | BP: SRP-dependent cotranslational protein targeting to membrane, translocation | MF: def: "CC_def: A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. | BP_def: The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.44095492229354 density:1 bootstrap:0.65396747 cc_score:0.466545 bp_score:0.163483 mf_score:0.0 relationship: child_of NeXO:8760 ! CC: endoplasmic reticulum Sec complex | BP: posttranslational protein targeting to membrane, translocation | MF:P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: NeXO:8080 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.50574529155562 density:0.166666666666667 bootstrap:0.533571073 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8964 ! CC: | BP: | MF:translation elongation factor activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:5833 name: CC: | BP: | MF:calmodulin-dependent protein kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.706166265 cc_score:0.0 bp_score:0.0190736 mf_score:0.291994 relationship: child_of NeXO:5834 ! CC: | BP: mitochondrial respiratory chain complex III biogenesis | MF: [Term] id: NeXO:8082 name: CC: nuclear condensin complex | BP: tRNA gene clustering | MF: def: "CC_def: A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus. | BP_def: The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.52927640294117 density:1 bootstrap:0.706384396 cc_score:0.648265 bp_score:0.555402 mf_score:0.0 relationship: child_of NeXO:8317 ! CC: | BP: | MF: [Term] id: NeXO:8083 name: CC: | BP: positive regulation of endodeoxyribonuclease activity | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28056354527725 density:1 bootstrap:0.86179943 cc_score:0.0 bp_score:0.221222 mf_score:0.0 relationship: child_of NeXO:9102 ! CC: | BP: protein unfolding | MF: relationship: linked_to NeXO:5430 ! CC: | BP: | MF: relationship: linked_to NeXO:7653 ! CC: | BP: | MF: [Term] id: NeXO:5632 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.09199701637097 density:0.666666666666667 bootstrap:0.871266613 cc_score:0.0 bp_score:0.0109423 mf_score:0.0 relationship: child_of NeXO:5633 ! CC: | BP: phospholipid translocation | MF:phospholipid-translocating ATPase activity [Term] id: NeXO:8088 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10387356828895 density:1 bootstrap:0.73343414 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8643 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: [Term] id: NeXO:8089 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6575044207676 density:0.333333333333333 bootstrap:0.556273608 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8936 ! CC: | BP: | MF: [Term] id: NeXO:5838 name: CC: | BP: negative regulation of strand invasion | MF:flap-structured DNA binding def: "CC_def: | BP_def: Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. | MF_def:Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.853916478 cc_score:0.0 bp_score:0.442797 mf_score:0.292879 relationship: child_of NeXO:7238 ! CC: | BP: strand invasion | MF: relationship: linked_to NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: [Term] id: NeXO:5839 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81901747 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6922 ! CC: | BP: | MF: [Term] id: NeXO:9929 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.29058271155125 density:0.0170779220779221 bootstrap:0.133350005 cc_score:0.0410642 bp_score:0.0349141 mf_score:0.0183256 relationship: child_of NeXO:9970 ! CC: | BP: | MF: [Term] id: NeXO:9920 name: CC: | BP: | MF:ATP-dependent protein binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79238882 cc_score:0.0 bp_score:0.0 mf_score:0.437695 relationship: child_of NeXO:9955 ! CC: | BP: protein import into nucleus, translocation | MF: relationship: linked_to NeXO:6399 ! CC: | BP: nucleotide phosphorylation | MF:adenylate kinase activity relationship: linked_to NeXO:7703 ! CC: septin cytoskeleton | BP: | MF: relationship: linked_to NeXO:8054 ! CC: | BP: | MF: relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:9362 ! CC: | BP: | MF: relationship: linked_to NeXO:9561 ! CC: | BP: | MF: relationship: linked_to NeXO:8418 ! CC: | BP: cellular response to misfolded protein | MF: relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding relationship: linked_to NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity [Term] id: NeXO:9922 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.3828198718831 density:0.0109034267912773 bootstrap:0.231858756 cc_score:0.0431985 bp_score:0.0941516 mf_score:0.0720122 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:9923 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.59741493619861 density:0.0158057395143488 bootstrap:0.067844992 cc_score:0.0145306 bp_score:0.0397598 mf_score:0.0443946 relationship: child_of NeXO:9976 ! CC: | BP: | MF: [Term] id: NeXO:8337 name: CC: | BP: negative regulation of pseudohyphal growth | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68650198992864 density:1 bootstrap:0.471297963 cc_score:0.0 bp_score:0.147473 mf_score:0.0701119 relationship: child_of NeXO:8979 ! CC: | BP: ultradian rhythm | MF: relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:7873 ! CC: | BP: | MF: [Term] id: NeXO:5633 name: CC: | BP: phospholipid translocation | MF:phospholipid-translocating ATPase activity def: "CC_def: | BP_def: The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. | MF_def:Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [NeXO-GO:term] namespace: NeXO comment: robustness:3.63776144191367 density:0.266666666666667 bootstrap:0.78107583 cc_score:0.0 bp_score:0.262949 mf_score:0.390855 relationship: child_of NeXO:6431 ! CC: | BP: lipid translocation | MF:phospholipid transporter activity [Term] id: NeXO:8335 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.43996489363304 density:0.9 bootstrap:0.79731693 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9027 ! CC: | BP: | MF: [Term] id: NeXO:6903 name: CC: | BP: | MF:histone acetyl-lysine binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with an acetylated lysine residue within a histone." [NeXO-GO:term] namespace: NeXO comment: robustness:2.30918979473555 density:1 bootstrap:0.883570293 cc_score:0.0 bp_score:0.0 mf_score:0.126249 relationship: child_of NeXO:7982 ! CC: | BP: | MF: relationship: linked_to NeXO:8785 ! CC: | BP: | MF: [Term] id: NeXO:6088 name: CC: | BP: sodium ion transmembrane transport | MF:sodium ion transmembrane transport def: "CC_def: | BP_def: A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | MF_def:A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6945648 cc_score:0.0 bp_score:0.314921 mf_score:0.229745 relationship: child_of NeXO:6755 ! CC: | BP: | MF:monovalent cation:hydrogen antiporter activity [Term] id: NeXO:6089 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89390115 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7228 ! CC: | BP: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process | MF: [Term] id: NeXO:6086 name: CC: | BP: sucrose catabolic process | MF:sucrose alpha-glucosidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. | MF_def:Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96805799373138 density:0.333333333333333 bootstrap:0.78425058 cc_score:0.0 bp_score:0.101584 mf_score:0.18419 relationship: child_of NeXO:6156 ! CC: | BP: | MF: [Term] id: NeXO:6087 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.626071357 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6753 ! CC: | BP: | MF: [Term] id: NeXO:6084 name: CC: | BP: | MF:acetyl-CoA C-acetyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61768731 cc_score:0.0 bp_score:0.0 mf_score:0.316405 relationship: child_of NeXO:7350 ! CC: | BP: trehalose metabolic process | MF:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:6085 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.65596026 cc_score:0.0 bp_score:0.0296778 mf_score:0.0 relationship: child_of NeXO:7702 ! CC: | BP: | MF: [Term] id: NeXO:6082 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.78465895071824 density:0.333333333333333 bootstrap:0.82771137 cc_score:0.0 bp_score:0.068493 mf_score:0.0 relationship: child_of NeXO:7001 ! CC: | BP: | MF: [Term] id: NeXO:6083 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84610871 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6519 ! CC: | BP: | MF:proton-dependent oligopeptide secondary active transmembrane transporter activity [Term] id: NeXO:6080 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.40911965448363 density:0.666666666666667 bootstrap:0.528919625 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6546 ! CC: | BP: regulation of transcription, mating-type specific | MF: [Term] id: NeXO:6081 name: CC: | BP: positive regulation of Ras protein signal transduction | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64885571249555 density:0.666666666666667 bootstrap:0.6394249 cc_score:0.0 bp_score:0.202319 mf_score:0.0 relationship: child_of NeXO:6082 ! CC: | BP: | MF: [Term] id: NeXO:6715 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.56850849213183 density:1 bootstrap:0.407657649 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6869 ! CC: | BP: | MF: relationship: linked_to NeXO:7801 ! CC: | BP: | MF: relationship: linked_to NeXO:7968 ! CC: | BP: | MF: relationship: linked_to NeXO:8077 ! CC: | BP: carbon catabolite activation of transcription from RNA polymerase II promoter | MF: relationship: linked_to NeXO:7893 ! CC: | BP: heme O biosynthetic process | MF:protoheme IX farnesyltransferase activity [Term] id: NeXO:6648 name: CC: | BP: | MF:Rho guanyl-nucleotide exchange factor activity def: "CC_def: | BP_def: | MF_def:Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71822395 cc_score:0.0 bp_score:0.0887584 mf_score:0.127327 relationship: child_of NeXO:7141 ! CC: | BP: | MF:inorganic diphosphatase activity [Term] id: NeXO:8003 name: CC: | BP: lysine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.96578138960279 density:0.120879120879121 bootstrap:0.44840106 cc_score:0.0 bp_score:0.257923 mf_score:0.0706426 relationship: child_of NeXO:9000 ! CC: | BP: | MF: [Term] id: NeXO:6186 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75141465 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6970 ! CC: | BP: UDP-glucose transport | MF:UDP-glucose transport [Term] id: NeXO:6644 name: CC: | BP: | MF:3-hydroxyisobutyryl-CoA hydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.410984793 cc_score:0.0 bp_score:0.0 mf_score:0.445561 relationship: child_of NeXO:6712 ! CC: | BP: | MF:CoA hydrolase activity [Term] id: NeXO:6647 name: CC: | BP: | MF:phosphatidylinositol-3-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84801819 cc_score:0.0 bp_score:0.0 mf_score:0.178761 relationship: child_of NeXO:8124 ! CC: mitotic spindle | BP: | MF: [Term] id: NeXO:6640 name: CC: | BP: regulation of anion transport | MF:voltage-gated anion channel activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.708462039 cc_score:0.0 bp_score:0.181438 mf_score:0.179903 relationship: child_of NeXO:7885 ! CC: | BP: DNA transport | MF:DNA transport [Term] id: NeXO:6641 name: CC: | BP: mitochondrial translational initiation | MF: def: "CC_def: | BP_def: The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92218533333888 density:1 bootstrap:0.61222684 cc_score:0.0 bp_score:0.126284 mf_score:0.0 relationship: child_of NeXO:6643 ! CC: | BP: | MF: [Term] id: NeXO:6643 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64373518391616 density:0.1 bootstrap:0.72180889 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7692 ! CC: | BP: | MF: [Term] id: NeXO:6902 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32753811153646 density:1 bootstrap:0.89766739 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7982 ! CC: | BP: | MF: relationship: linked_to NeXO:9546 ! CC: | BP: antisense RNA metabolic process | MF:DNA topoisomerase activity relationship: linked_to NeXO:8785 ! CC: | BP: | MF: [Term] id: NeXO:5903 name: CC: | BP: negative regulation of transcription from RNA polymerase II promoter during meiosis | MF: def: "CC_def: | BP_def: A cell cycle process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89159200871585 density:1 bootstrap:0.592893635 cc_score:0.0 bp_score:0.594541 mf_score:0.0 relationship: child_of NeXO:6112 ! CC: | BP: regulation of transcription from RNA polymerase II promoter during meiosis | MF: relationship: linked_to NeXO:6964 ! CC: ribonucleoside-diphosphate reductase complex | BP: deoxyribonucleoside diphosphate metabolic process | MF:ribonucleoside-diphosphate reductase activity [Term] id: NeXO:5900 name: CC: | BP: sodium:hydrogen antiporter activity | MF:potassium-transporting ATPase activity def: "CC_def: | BP_def: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69164206 cc_score:0.0 bp_score:0.21875 mf_score:0.295136 relationship: child_of NeXO:5902 ! CC: | BP: sodium ion transport | MF:sodium-exporting ATPase activity, phosphorylative mechanism [Term] id: NeXO:5901 name: CC: | BP: cellular sodium ion homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.678141657 cc_score:0.0 bp_score:0.220337 mf_score:0.0 relationship: child_of NeXO:5902 ! CC: | BP: sodium ion transport | MF:sodium-exporting ATPase activity, phosphorylative mechanism [Term] id: NeXO:5906 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2644954868233 density:1 bootstrap:0.849698332 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5907 ! CC: | BP: | MF: [Term] id: NeXO:5907 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.55841783561173 density:0.333333333333333 bootstrap:0.491752849 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6593 ! CC: | BP: | MF: [Term] id: NeXO:5905 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.802237711 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6873 ! CC: | BP: | MF: relationship: linked_to NeXO:6497 ! CC: | BP: | MF: [Term] id: NeXO:5908 name: CC: | BP: | MF:5-oxoprolinase (ATP-hydrolyzing) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89959491 cc_score:0.0 bp_score:0.0 mf_score:0.448334 relationship: child_of NeXO:6574 ! CC: | BP: XMP salvage | MF:xanthine phosphoribosyltransferase activity [Term] id: NeXO:5909 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22643979623321 density:1 bootstrap:0.82137931 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6735 ! CC: | BP: | MF: [Term] id: NeXO:6497 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.9775181778398 density:1 bootstrap:0.68421135 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7252 ! CC: | BP: | MF: relationship: linked_to NeXO:6169 ! CC: | BP: | MF: [Term] id: NeXO:6182 name: CC: AP-2 adaptor complex | BP: | MF: def: "CC_def: A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56913612827635 density:1 bootstrap:0.703597689 cc_score:0.660786 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6565 ! CC: | BP: | MF: [Term] id: NeXO:7801 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94825482222776 density:1 bootstrap:0.86101066 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8575 ! CC: | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: relationship: linked_to NeXO:7530 ! CC: | BP: | MF: [Term] id: NeXO:7800 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.637502616 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7935 ! CC: | BP: | MF: [Term] id: NeXO:7803 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.58326778576602 density:0.0514705882352941 bootstrap:0.397003639 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8469 ! CC: organelle membrane contact site | BP: | MF: [Term] id: NeXO:7802 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06869212282206 density:1 bootstrap:0.709109932 cc_score:0.0 bp_score:0.0115765 mf_score:0.0 relationship: child_of NeXO:9750 ! CC: | BP: negative regulation of meiosis | MF: relationship: linked_to NeXO:9282 ! CC: Set3 complex | BP: positive regulation of stress-activated MAPK cascade | MF:NAD-independent histone deacetylase activity relationship: linked_to NeXO:6593 ! CC: | BP: | MF: relationship: linked_to NeXO:9312 ! CC: | BP: | MF: relationship: linked_to NeXO:8785 ! CC: | BP: | MF: [Term] id: NeXO:7805 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.83556869995699 density:0.666666666666667 bootstrap:0.732745715 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8827 ! CC: | BP: | MF: [Term] id: NeXO:7807 name: CC: | BP: | MF:mRNA methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.418920404 cc_score:0.0 bp_score:0.0 mf_score:0.158629 relationship: child_of NeXO:8588 ! CC: | BP: | MF: [Term] id: NeXO:7806 name: CC: | BP: negative regulation of nucleotide metabolic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87228888922628 density:0.266666666666667 bootstrap:0.206904763 cc_score:0.0538719 bp_score:0.215761 mf_score:0.0 relationship: child_of NeXO:8823 ! CC: internal side of plasma membrane | BP: regulation of cAMP biosynthetic process | MF: [Term] id: NeXO:7809 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73965809 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8422 ! CC: | BP: | MF: relationship: linked_to NeXO:6679 ! CC: | BP: | MF: [Term] id: NeXO:7808 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77107884 cc_score:0.0 bp_score:0.0880961 mf_score:0.0960883 relationship: child_of NeXO:8875 ! CC: | BP: | MF: [Term] id: NeXO:9904 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.6369333746694 density:0.75438596491228 bootstrap:0.453299807 cc_score:0.0 bp_score:0.0781297 mf_score:0.0 relationship: child_of NeXO:10022 ! CC: cytosolic ribosome | BP: cytoplasmic translation | MF:structural constituent of ribosome relationship: linked_to NeXO:10004 ! CC: | BP: | MF: relationship: linked_to NeXO:10005 ! CC: cytosolic large ribosomal subunit | BP: | MF: relationship: linked_to NeXO:10003 ! CC: cytosolic small ribosomal subunit | BP: | MF: [Term] id: NeXO:6549 name: CC: | BP: protein neddylation | MF:small protein activating enzyme activity def: "CC_def: | BP_def: Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. | MF_def:Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [NeXO-GO:term] namespace: NeXO comment: robustness:4.03910162396769 density:0.333333333333333 bootstrap:0.73527817 cc_score:0.0 bp_score:0.568482 mf_score:0.143084 relationship: child_of NeXO:7084 ! CC: | BP: | MF: [Term] id: NeXO:8740 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.07851040703737 density:0.219047619047619 bootstrap:0.58146836 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9248 ! CC: | BP: | MF: [Term] id: NeXO:6398 name: CC: | BP: vesicle fusion with vacuole | MF: def: "CC_def: | BP_def: The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.81703755985681 density:0.5 bootstrap:0.590923384 cc_score:0.0 bp_score:0.139113 mf_score:0.0 relationship: child_of NeXO:6522 ! CC: GID complex | BP: negative regulation of gluconeogenesis | MF: [Term] id: NeXO:6399 name: CC: | BP: nucleotide phosphorylation | MF:adenylate kinase activity def: "CC_def: | BP_def: The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. | MF_def:Catalysis of the reaction: ATP + AMP = 2 ADP." [NeXO-GO:term] namespace: NeXO comment: robustness:1.55129095914087 density:0.1 bootstrap:0.6429024 cc_score:0.0 bp_score:0.264862 mf_score:0.208221 relationship: child_of NeXO:6525 ! CC: | BP: ADP biosynthetic process | MF:dolichyl-phosphate beta-D-mannosyltransferase activity [Term] id: NeXO:9900 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.92933110395835 density:0.0218412698412698 bootstrap:0.104546557 cc_score:0.0 bp_score:0.0652366 mf_score:0.0467373 relationship: child_of NeXO:9954 ! CC: | BP: | MF: [Term] id: NeXO:6392 name: CC: | BP: long-chain fatty acid metabolic process | MF:very long-chain fatty acid-CoA ligase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18. | MF_def:Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18." [NeXO-GO:term] namespace: NeXO comment: robustness:1.6646294148642 density:0.333333333333333 bootstrap:0.561066313 cc_score:0.0 bp_score:0.567855 mf_score:0.439356 relationship: child_of NeXO:6938 ! CC: | BP: N-terminal peptidyl-glycine N-myristoylation | MF:glycylpeptide N-tetradecanoyltransferase activity [Term] id: NeXO:6393 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.98109035564566 density:0.333333333333333 bootstrap:0.79467149 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6679 ! CC: | BP: | MF: relationship: linked_to NeXO:8422 ! CC: | BP: | MF: [Term] id: NeXO:6391 name: CC: | BP: purine ribonucleoside catabolic process | MF:bis(5'-adenosyl)-hexaphosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. | MF_def:Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71737076 cc_score:0.0 bp_score:0.201816 mf_score:0.271381 relationship: child_of NeXO:7543 ! CC: | BP: | MF: [Term] id: NeXO:6900 name: CC: | BP: histone arginine methylation | MF:protein-arginine omega-N symmetric methyltransferase activity def: "CC_def: | BP_def: The modification of a histone by addition of a methyl group to an arginine residue. | MF_def:Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.720254146 cc_score:0.0 bp_score:0.439721 mf_score:0.44834 relationship: child_of NeXO:7722 ! CC: | BP: sterol import | MF:histone-arginine N-methyltransferase activity relationship: linked_to NeXO:9351 ! CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity relationship: linked_to NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: [Term] id: NeXO:6395 name: CC: | BP: oligosaccharide-lipid intermediate biosynthetic process | MF:chitobiosyldiphosphodolichol beta-mannosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. | MF_def:Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [NeXO-GO:term] namespace: NeXO comment: robustness:3.0865961746748 density:0.666666666666667 bootstrap:0.86822556 cc_score:0.0 bp_score:0.405701 mf_score:0.315842 relationship: child_of NeXO:6396 ! CC: | BP: dolichol-linked oligosaccharide biosynthetic process | MF: [Term] id: NeXO:9427 name: CC: | BP: regulation of transcription factor import into nucleus | MF:MAP kinase kinase kinase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. | MF_def:Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24952281324798 density:1 bootstrap:0.838499196 cc_score:0.0 bp_score:0.194277 mf_score:0.180186 relationship: child_of NeXO:9841 ! CC: | BP: response to acid | MF: relationship: linked_to NeXO:9077 ! CC: | BP: activation of Rho GTPase activity | MF:protein kinase C activity relationship: linked_to NeXO:9470 ! CC: | BP: | MF:voltage-gated calcium channel activity relationship: linked_to NeXO:8770 ! CC: alpha-1,6-mannosyltransferase complex | BP: substituted mannan metabolic process | MF: relationship: linked_to NeXO:8830 ! CC: | BP: regulation of initiation of mating projection growth | MF:protein serine/threonine/tyrosine kinase activity relationship: linked_to NeXO:9304 ! CC: | BP: | MF: relationship: linked_to NeXO:7229 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:9523 ! CC: | BP: | MF:cyclin binding relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity [Term] id: NeXO:6188 name: CC: | BP: iron-sulfur cluster assembly | MF: def: "CC_def: | BP_def: The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.48598764792433 density:0.214285714285714 bootstrap:0.85940072 cc_score:0.0 bp_score:0.210636 mf_score:0.0605786 relationship: child_of NeXO:7294 ! CC: | BP: | MF: [Term] id: NeXO:9601 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.13856991489282 density:0.16600790513834 bootstrap:0.184690734 cc_score:0.0 bp_score:0.0638042 mf_score:0.0 relationship: child_of NeXO:9874 ! CC: | BP: | MF: [Term] id: NeXO:9600 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.50553848995728 density:1 bootstrap:0.444469674 cc_score:0.0 bp_score:0.0486137 mf_score:0.0 relationship: child_of NeXO:9685 ! CC: | BP: | MF: relationship: linked_to NeXO:9426 ! CC: | BP: | MF: [Term] id: NeXO:8134 name: CC: | BP: negative regulation of cell differentiation | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.72677014335771 density:1 bootstrap:0.767120157 cc_score:0.0 bp_score:0.161629 mf_score:0.0 relationship: child_of NeXO:8887 ! CC: | BP: | MF: [Term] id: NeXO:9603 name: CC: synaptonemal complex | BP: gene conversion at mating-type locus | MF:DNA secondary structure binding def: "CC_def: A proteinaceous scaffold found between homologous chromosomes during meiosis. | BP_def: The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. | MF_def:Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [NeXO-GO:term] namespace: NeXO comment: robustness:6.77996345621447 density:0.384615384615385 bootstrap:0.349335608 cc_score:0.16959 bp_score:0.107523 mf_score:0.147157 relationship: child_of NeXO:9857 ! CC: nucleotide-excision repair complex | BP: mismatch repair | MF:damaged DNA binding [Term] id: NeXO:9498 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.879035825630295 density:0.0329670329670330 bootstrap:0.117882753 cc_score:0.0 bp_score:0.0163992 mf_score:0.0 relationship: child_of NeXO:9737 ! CC: | BP: | MF: [Term] id: NeXO:9499 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93373181665814 density:0.178571428571429 bootstrap:0.199689082 cc_score:0.0 bp_score:0.01447 mf_score:0.0 relationship: child_of NeXO:9782 ! CC: | BP: | MF: [Term] id: NeXO:9148 name: CC: | BP: spindle pole body duplication in nuclear envelope | MF: def: "CC_def: | BP_def: Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence. An example of this is found in Saccharomyces cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.677726565394 density:0.571428571428571 bootstrap:0.365592345 cc_score:0.0 bp_score:0.239269 mf_score:0.0 relationship: child_of NeXO:9681 ! CC: central plaque of spindle pole body | BP: spindle pole body duplication | MF: [Term] id: NeXO:9602 name: CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: def: "CC_def: | BP_def: A mitotic G1/S transition checkpoint that blocks entry into S phase in response to DNA damage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.3983826673361 density:0.333333333333333 bootstrap:0.208731003 cc_score:0.0 bp_score:0.137053 mf_score:0.0 relationship: child_of NeXO:9857 ! CC: nucleotide-excision repair complex | BP: mismatch repair | MF:damaged DNA binding relationship: linked_to NeXO:7903 ! CC: | BP: | MF: relationship: linked_to NeXO:9266 ! CC: mismatch repair complex | BP: meiotic mismatch repair | MF:mismatched DNA binding [Term] id: NeXO:7979 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.24711944123234 density:0.466666666666667 bootstrap:0.82202916 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9150 ! CC: | BP: | MF: [Term] id: NeXO:7978 name: CC: | BP: glutamine family amino acid catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.6502211228906 density:0.1 bootstrap:0.239483242 cc_score:0.0 bp_score:0.107671 mf_score:0.0551837 relationship: child_of NeXO:9110 ! CC: | BP: | MF: [Term] id: NeXO:7659 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66236334553912 density:1 bootstrap:0.457903281 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8496 ! CC: | BP: | MF: [Term] id: NeXO:7975 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2486165523538 density:1 bootstrap:0.837823723 cc_score:0.0 bp_score:0.0 mf_score:0.037552 relationship: child_of NeXO:9464 ! CC: DNA-directed RNA polymerase III complex | BP: tRNA transcription from RNA polymerase III promoter | MF: relationship: linked_to NeXO:7526 ! CC: | BP: | MF: relationship: linked_to NeXO:8054 ! CC: | BP: | MF: [Term] id: NeXO:9605 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.967091482540211 density:0.0444444444444444 bootstrap:0.178461123 cc_score:0.0 bp_score:0.0479511 mf_score:0.0282347 relationship: child_of NeXO:9962 ! CC: | BP: modification-dependent protein catabolic process | MF: [Term] id: NeXO:9492 name: CC: ER to Golgi transport vesicle membrane | BP: COPII-coated vesicle budding | MF: def: "CC_def: The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. | BP_def: The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII vesicle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.37974049984568 density:0.5 bootstrap:0.43185334 cc_score:0.206931 bp_score:0.362326 mf_score:0.0 relationship: child_of NeXO:9820 ! CC: | BP: vesicle targeting, to, from or within Golgi | MF: [Term] id: NeXO:9493 name: CC: nucleoplasmic THO complex | BP: | MF: def: "CC_def: The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.15134442565367 density:0.294871794871795 bootstrap:0.282444537 cc_score:0.165224 bp_score:0.0879399 mf_score:0.0 relationship: child_of NeXO:9832 ! CC: | BP: | MF: [Term] id: NeXO:9494 name: CC: checkpoint clamp complex | BP: mitotic cell cycle G1/S transition checkpoint | MF:exodeoxyribonuclease III activity def: "CC_def: Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. | BP_def: A cell cycle checkpoint that blocks entry into S phase of the mitotic cell cycle. | MF_def:Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [NeXO-GO:term] namespace: NeXO comment: robustness:8.3378590814924 density:1 bootstrap:0.76793206 cc_score:0.438645 bp_score:0.212906 mf_score:0.149885 relationship: child_of NeXO:9855 ! CC: | BP: DNA integrity checkpoint | MF: relationship: linked_to NeXO:9495 ! CC: | BP: negative regulation of transposition, RNA-mediated | MF: relationship: linked_to NeXO:9460 ! CC: | BP: gene conversion at mating-type locus, DNA double-strand break processing | MF:endodeoxyribonuclease activity relationship: linked_to NeXO:9549 ! CC: replication fork protection complex | BP: replication fork protection | MF: [Term] id: NeXO:9495 name: CC: | BP: negative regulation of transposition, RNA-mediated | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.83752403246713 density:0.545454545454545 bootstrap:0.422301239 cc_score:0.0 bp_score:0.144901 mf_score:0.0 relationship: child_of NeXO:9589 ! CC: | BP: non-recombinational repair | MF:double-stranded telomeric DNA binding [Term] id: NeXO:9144 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.55616961388376 density:0.833333333333333 bootstrap:0.445519122 cc_score:0.0 bp_score:0.0160297 mf_score:0.0 relationship: child_of NeXO:9395 ! CC: anaphase-promoting complex | BP: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: relationship: linked_to NeXO:6066 ! CC: | BP: mitotic metaphase/anaphase transition | MF: relationship: linked_to NeXO:5738 ! CC: | BP: | MF:positive regulation of mitotic metaphase/anaphase transition [Term] id: NeXO:9604 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.88319311576236 density:0.857142857142857 bootstrap:0.235049363 cc_score:0.0 bp_score:0.0744041 mf_score:0.0 relationship: child_of NeXO:9702 ! CC: | BP: | MF: [Term] id: NeXO:6266 name: CC: | BP: | MF:polyamine transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.70358572680222 density:0.133333333333333 bootstrap:0.390247437 cc_score:0.0 bp_score:0.099766 mf_score:0.107819 relationship: child_of NeXO:7445 ! CC: | BP: | MF: [Term] id: NeXO:6267 name: CC: | BP: cellular response to oleic acid | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.57309205 cc_score:0.0 bp_score:0.125553 mf_score:0.0 relationship: child_of NeXO:6268 ! CC: | BP: | MF: [Term] id: NeXO:6264 name: CC: | BP: negative regulation of fatty acid metabolic process | MF:NAD(P)H nitroreductase activity def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. | MF_def:Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.566135484 cc_score:0.0 bp_score:0.440132 mf_score:0.293559 relationship: child_of NeXO:6265 ! CC: | BP: spermine transport | MF:spermine transmembrane transporter activity [Term] id: NeXO:6265 name: CC: | BP: spermine transport | MF:spermine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [NeXO-GO:term] namespace: NeXO comment: robustness:1.73796456217529 density:0.333333333333333 bootstrap:0.611590736 cc_score:0.0 bp_score:0.344139 mf_score:0.34461 relationship: child_of NeXO:6266 ! CC: | BP: | MF:polyamine transmembrane transporter activity [Term] id: NeXO:6262 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.875042678 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7497 ! CC: | BP: | MF: [Term] id: NeXO:6263 name: CC: | BP: | MF:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [NeXO-GO:term] namespace: NeXO comment: robustness:2.15466443536125 density:1 bootstrap:0.76927414 cc_score:0.0 bp_score:0.0 mf_score:0.444034 relationship: child_of NeXO:7229 ! CC: | BP: | MF: [Term] id: NeXO:6260 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.852950528 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6952 ! CC: | BP: | MF: [Term] id: NeXO:9606 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.38307728841122 density:0.169590643274854 bootstrap:0.289703627 cc_score:0.0 bp_score:0.0 mf_score:0.0352154 relationship: child_of NeXO:9752 ! CC: | BP: | MF: [Term] id: NeXO:6268 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68046371404269 density:0.333333333333333 bootstrap:0.571791037 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6269 ! CC: | BP: | MF: [Term] id: NeXO:6269 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.48113672254725 density:0.142857142857143 bootstrap:0.431722825 cc_score:0.0 bp_score:0.0679305 mf_score:0.0 relationship: child_of NeXO:7176 ! CC: | BP: | MF: [Term] id: NeXO:6064 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.80160069918304 density:0.333333333333333 bootstrap:0.83781353 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6065 ! CC: | BP: | MF: [Term] id: NeXO:6065 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.38163527678672 density:0.155555555555556 bootstrap:0.77743965 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7452 ! CC: | BP: | MF: [Term] id: NeXO:6066 name: CC: | BP: mitotic metaphase/anaphase transition | MF: def: "CC_def: | BP_def: The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.2570300299974 density:0.952380952380952 bootstrap:0.89412506 cc_score:0.0 bp_score:0.128299 mf_score:0.0 relationship: child_of NeXO:8302 ! CC: | BP: | MF: [Term] id: NeXO:6067 name: CC: | BP: regulation of glycogen metabolic process | MF:glycogenin glucosyltransferase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. | MF_def:Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.661818581 cc_score:0.0 bp_score:0.145522 mf_score:0.236668 relationship: child_of NeXO:6995 ! CC: | BP: glycogen biosynthetic process | MF: [Term] id: NeXO:6060 name: CC: | BP: 'de novo' pyrimidine base biosynthetic process | MF:aspartate carbamoyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. | MF_def:Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.9108324791229 density:1 bootstrap:0.84476635 cc_score:0.0 bp_score:0.390561 mf_score:0.300524 relationship: child_of NeXO:6061 ! CC: | BP: negative regulation of pyrimidine base metabolic process | MF:dihydroorotase activity [Term] id: NeXO:6061 name: CC: | BP: negative regulation of pyrimidine base metabolic process | MF:dihydroorotase activity def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases. | MF_def:Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.37833903121373 density:0.5 bootstrap:0.755099586 cc_score:0.0 bp_score:0.205875 mf_score:0.203105 relationship: child_of NeXO:7579 ! CC: | BP: pyrimidine base biosynthetic process | MF: [Term] id: NeXO:9548 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.7351503063342 density:0.333333333333333 bootstrap:0.337166569 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9804 ! CC: | BP: | MF: relationship: linked_to NeXO:8930 ! CC: | BP: establishment of mitotic sister chromatid cohesion | MF: [Term] id: NeXO:9549 name: CC: replication fork protection complex | BP: replication fork protection | MF: def: "CC_def: A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. | BP_def: Any process that prevents the collapse of stalled replication forks. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.7900446652738 density:0.857142857142857 bootstrap:0.454460918 cc_score:0.144049 bp_score:0.238489 mf_score:0.0 relationship: child_of NeXO:9699 ! CC: | BP: negative regulation of DNA-dependent DNA replication | MF: relationship: linked_to NeXO:9411 ! CC: CMG complex | BP: S phase of mitotic cell cycle | MF:DNA replication origin binding [Term] id: NeXO:9546 name: CC: | BP: antisense RNA metabolic process | MF:DNA topoisomerase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis. | MF_def:Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:1.14923342453745 density:0.333333333333333 bootstrap:0.267421033 cc_score:0.0 bp_score:0.2306 mf_score:0.143451 relationship: child_of NeXO:9751 ! CC: | BP: | MF: relationship: linked_to NeXO:7982 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:8346 ! CC: Piccolo NuA4 histone acetyltransferase complex | BP: | MF:H4 histone acetyltransferase activity relationship: linked_to NeXO:9624 ! CC: | BP: negative regulation of transcription during meiosis | MF: [Term] id: NeXO:9547 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.70445561319687 density:0.104838709677419 bootstrap:0.297096108 cc_score:0.0 bp_score:0.0100064 mf_score:0.0 relationship: child_of NeXO:9918 ! CC: | BP: | MF: [Term] id: NeXO:9544 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.0099464532113 density:0.0692488262910798 bootstrap:0.27898257 cc_score:0.0 bp_score:0.0748322 mf_score:0.0119589 relationship: child_of NeXO:9814 ! CC: | BP: | MF: [Term] id: NeXO:9542 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32160478944505 density:0.0289617486338798 bootstrap:0.126783846 cc_score:0.0 bp_score:0.0301011 mf_score:0.0396795 relationship: child_of NeXO:9767 ! CC: | BP: | MF: [Term] id: NeXO:6069 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82765431180897 density:0.166666666666667 bootstrap:0.78609921 cc_score:0.0 bp_score:0.0832969 mf_score:0.0 relationship: child_of NeXO:7403 ! CC: | BP: | MF: [Term] id: NeXO:9540 name: CC: | BP: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation | MF: def: "CC_def: | BP_def: The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68686031 cc_score:0.0 bp_score:0.439861 mf_score:0.0 relationship: child_of NeXO:9756 ! CC: | BP: histone dephosphorylation | MF: relationship: linked_to NeXO:8851 ! CC: | BP: cellular response to phosphate starvation | MF: relationship: linked_to NeXO:7872 ! CC: | BP: positive regulation of sodium ion transport | MF: relationship: linked_to NeXO:8560 ! CC: | BP: | MF:rRNA (adenine-N6,N6-)-dimethyltransferase activity [Term] id: NeXO:9726 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.27966427683118 density:0.028906955736224 bootstrap:0.117760877 cc_score:0.0764794 bp_score:0.0415463 mf_score:0.0 relationship: child_of NeXO:9907 ! CC: | BP: | MF: [Term] id: NeXO:9727 name: CC: | BP: mitotic cell cycle G2/M transition decatenation checkpoint | MF: def: "CC_def: | BP_def: A mitotic cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until sister chromatids are sufficiently separated, with concatenated molecules topologically resolved. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.58694243807564 density:0.678571428571429 bootstrap:0.438511381 cc_score:0.0365908 bp_score:0.319696 mf_score:0.0 relationship: child_of NeXO:9866 ! CC: | BP: mitotic cell cycle G2/M transition checkpoint | MF: relationship: linked_to NeXO:9625 ! CC: | BP: maintenance of meiotic sister chromatid cohesion | MF: relationship: linked_to NeXO:9431 ! CC: dynein complex | BP: nuclear migration | MF:motor activity [Term] id: NeXO:9724 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.3340034629157 density:0.369565217391304 bootstrap:0.61003756 cc_score:0.0 bp_score:0.0256464 mf_score:0.0 relationship: child_of NeXO:9823 ! CC: | BP: | MF: [Term] id: NeXO:9725 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.22563835515024 density:0.373626373626374 bootstrap:0.458238172 cc_score:0.0 bp_score:0.0139468 mf_score:0.0 relationship: child_of NeXO:9902 ! CC: | BP: membrane budding | MF: [Term] id: NeXO:9722 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.88462314901114 density:0.021256038647343 bootstrap:0.114348317 cc_score:0.0 bp_score:0.0437555 mf_score:0.0 relationship: child_of NeXO:9872 ! CC: peroxisome | BP: | MF: [Term] id: NeXO:9723 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.18769820529584 density:0.388888888888889 bootstrap:0.280655956 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9817 ! CC: | BP: | MF: [Term] id: NeXO:8136 name: CC: | BP: negative regulation of MAPKKK cascade | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.895127702466673 density:0.0476190476190476 bootstrap:0.26581332 cc_score:0.0 bp_score:0.10553 mf_score:0.0 relationship: child_of NeXO:8540 ! CC: | BP: | MF: [Term] id: NeXO:9721 name: CC: | BP: intracellular protein transmembrane transport | MF:protein transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a protein from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:9.67213927449651 density:0.195767195767196 bootstrap:0.355098357 cc_score:0.0742445 bp_score:0.232845 mf_score:0.209303 relationship: child_of NeXO:9828 ! CC: organelle inner membrane | BP: establishment of protein localization in mitochondrion | MF:channel activity [Term] id: NeXO:9728 name: CC: cytoplasmic microtubule | BP: microtubule-based movement | MF: def: "CC_def: Any microtubule in the cytoplasm of a cell. | BP_def: A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.2279495630349 density:0.538095238095238 bootstrap:0.323827548 cc_score:0.258469 bp_score:0.181139 mf_score:0.0 relationship: child_of NeXO:9906 ! CC: microtubule associated complex | BP: cellular component movement | MF: [Term] id: NeXO:7095 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87790499940576 density:0.2 bootstrap:0.426106643 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7763 ! CC: | BP: | MF: [Term] id: NeXO:5128 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8197907 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5200 ! CC: | BP: | MF: [Term] id: NeXO:5129 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.496014063 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5150 ! CC: | BP: | MF:dipeptidyl-peptidase activity [Term] id: NeXO:7084 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.32849971133351 density:0.104761904761905 bootstrap:0.560214719 cc_score:0.0 bp_score:0.0240871 mf_score:0.0 relationship: child_of NeXO:8658 ! CC: | BP: | MF: [Term] id: NeXO:5124 name: CC: | BP: | MF:potassium:hydrogen antiporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88214267 cc_score:0.0 bp_score:0.0381766 mf_score:0.178727 relationship: child_of NeXO:7209 ! CC: | BP: acetate fermentation | MF:acetate-CoA ligase activity [Term] id: NeXO:5125 name: CC: | BP: | MF:nucleoside triphosphate adenylate kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87653585 cc_score:0.0 bp_score:0.0 mf_score:0.439623 relationship: child_of NeXO:7078 ! CC: | BP: | MF: [Term] id: NeXO:5126 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89328818 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5153 ! CC: | BP: | MF: [Term] id: NeXO:5127 name: CC: | BP: GO:2001172 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9035602 cc_score:0.0 bp_score:0.440457 mf_score:0.0567234 relationship: child_of NeXO:5494 ! CC: | BP: L-phenylalanine catabolic process | MF: [Term] id: NeXO:5122 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63695572 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5123 ! CC: | BP: | MF: [Term] id: NeXO:5123 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75724841 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5128 ! CC: | BP: | MF: [Term] id: NeXO:9845 name: CC: COPI-coated vesicle | BP: ER to Golgi vesicle-mediated transport | MF: def: "CC_def: A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. | BP_def: The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.78718859828581 density:0.333333333333333 bootstrap:0.254563706 cc_score:0.11301 bp_score:0.108467 mf_score:0.0361684 relationship: child_of NeXO:9964 ! CC: Golgi apparatus part | BP: vesicle fusion | MF: [Term] id: NeXO:7236 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.37142405118655 density:0.178571428571429 bootstrap:0.606999867 cc_score:0.0 bp_score:0.0649541 mf_score:0.0987911 relationship: child_of NeXO:8216 ! CC: | BP: | MF: [Term] id: NeXO:7379 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.53546707731522 density:0.0545454545454545 bootstrap:0.293847168 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8447 ! CC: | BP: | MF: [Term] id: NeXO:5434 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07542171503351 density:0.333333333333333 bootstrap:0.87215119 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6998 ! CC: | BP: | MF: [Term] id: NeXO:8899 name: CC: | BP: | MF:CDP-choline pathway def: "CC_def: | BP_def: | MF_def:The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [NeXO-GO:term] namespace: NeXO comment: robustness:3.5250968271476 density:0.222222222222222 bootstrap:0.322388815 cc_score:0.0 bp_score:0.0815964 mf_score:0.120252 relationship: child_of NeXO:9591 ! CC: | BP: | MF: [Term] id: NeXO:7237 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.338582609 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8861 ! CC: | BP: | MF: [Term] id: NeXO:8897 name: CC: | BP: | MF:radical SAM enzyme activity def: "CC_def: | BP_def: | MF_def:Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical." [NeXO-GO:term] namespace: NeXO comment: robustness:3.90678118644663 density:0.6 bootstrap:0.494399356 cc_score:0.0 bp_score:0.0 mf_score:0.136063 relationship: child_of NeXO:9221 ! CC: | BP: | MF: [Term] id: NeXO:7372 name: CC: | BP: heterochromatin formation involved in chromatin silencing | MF: def: "CC_def: | BP_def: Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52007535895017 density:0.166666666666667 bootstrap:0.543775313 cc_score:0.0 bp_score:0.166698 mf_score:0.0112347 relationship: child_of NeXO:8406 ! CC: | BP: | MF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:7371 name: CC: integral to membrane of membrane fraction | BP: mannose metabolic process | MF:alpha-mannosidase activity def: "CC_def: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes. | BP_def: The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. | MF_def:Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.306752752 cc_score:0.175491 bp_score:0.112202 mf_score:0.236807 relationship: child_of NeXO:8068 ! CC: | BP: | MF: [Term] id: NeXO:8894 name: CC: retromer complex | BP: | MF: def: "CC_def: A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.44045713864974 density:0.333333333333333 bootstrap:0.42012618 cc_score:0.263896 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9172 ! CC: | BP: | MF: relationship: linked_to NeXO:8227 ! CC: GARP complex | BP: | MF: [Term] id: NeXO:7377 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30114914654215 density:0.0421052631578947 bootstrap:0.303535588 cc_score:0.0 bp_score:0.0127562 mf_score:0.0 relationship: child_of NeXO:8637 ! CC: | BP: | MF: [Term] id: NeXO:7234 name: CC: | BP: ATP citrate synthase activity | MF:CoA-ligase activity def: "CC_def: | BP_def: Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. | MF_def:Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:4.72465776218052 density:0.333333333333333 bootstrap:0.72921893 cc_score:0.0 bp_score:0.118685 mf_score:0.193158 relationship: child_of NeXO:8440 ! CC: | BP: negative regulation of cellular carbohydrate metabolic process | MF: [Term] id: NeXO:8891 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.26029801815228 density:1 bootstrap:0.587100945 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9172 ! CC: | BP: | MF: relationship: linked_to NeXO:9650 ! CC: retromer complex, inner shell | BP: retrograde transport, endosome to Golgi | MF: [Term] id: NeXO:7374 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.46739766140227 density:1 bootstrap:0.66405719 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7739 ! CC: | BP: | MF: [Term] id: NeXO:7235 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.16949600517812 density:0.0277777777777778 bootstrap:0.54859855 cc_score:0.0 bp_score:0.0960835 mf_score:0.041033 relationship: child_of NeXO:8658 ! CC: | BP: | MF: [Term] id: NeXO:9269 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.2791211310618 density:0.411764705882353 bootstrap:0.70894364 cc_score:0.0 bp_score:0.0451699 mf_score:0.0 relationship: child_of NeXO:9712 ! CC: | BP: sulfur amino acid biosynthetic process | MF: [Term] id: NeXO:7232 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.74010378972311 density:1 bootstrap:0.772619185 cc_score:0.0 bp_score:0.0884756 mf_score:0.0 relationship: child_of NeXO:9209 ! CC: Set1C/COMPASS complex | BP: histone H3-K4 methylation | MF:histone methyltransferase activity (H3-K4 specific) relationship: linked_to NeXO:8236 ! CC: | BP: histone ubiquitination | MF: [Term] id: NeXO:5438 name: CC: | BP: thiamine transport | MF:thiamine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. | MF_def:Catalysis of the transfer of thiamine from one side of the membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [NeXO-GO:term] namespace: NeXO comment: robustness:3.17833554031152 density:0.666666666666667 bootstrap:0.92060309 cc_score:0.0 bp_score:0.136638 mf_score:0.203565 relationship: child_of NeXO:6181 ! CC: | BP: calcium ion transport | MF:calcium ion transmembrane transporter activity [Term] id: NeXO:9844 name: CC: | BP: | MF:Ras GTPase activator activity def: "CC_def: | BP_def: | MF_def:Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [NeXO-GO:term] namespace: NeXO comment: robustness:5.80030970798818 density:0.117241379310345 bootstrap:0.217972796 cc_score:0.0688801 bp_score:0.0691145 mf_score:0.109947 relationship: child_of NeXO:9991 ! CC: cortical actin cytoskeleton | BP: actin filament-based process | MF:cytoskeletal protein binding [Term] id: NeXO:9194 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.16887667343863 density:0.0952380952380952 bootstrap:0.202313801 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9553 ! CC: extrinsic to internal side of plasma membrane | BP: regulation of nitrogen utilization | MF: [Term] id: NeXO:7230 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.63740266875942 density:0.238095238095238 bootstrap:0.65219113 cc_score:0.0 bp_score:0.0796816 mf_score:0.0 relationship: child_of NeXO:7322 ! CC: | BP: | MF: [Term] id: NeXO:6994 name: CC: | BP: triglyceride catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.358481823 cc_score:0.0 bp_score:0.176425 mf_score:0.0 relationship: child_of NeXO:7691 ! CC: | BP: | MF: [Term] id: NeXO:7231 name: CC: | BP: dUTP catabolic process | MF:dUTP diphosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. | MF_def:Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.84474734800362 density:0.178571428571429 bootstrap:0.78940059 cc_score:0.0 bp_score:0.101102 mf_score:0.103824 relationship: child_of NeXO:8491 ! CC: | BP: | MF: [Term] id: NeXO:5835 name: CC: | BP: | MF:L-serine ammonia-lyase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-serine = pyruvate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:2.51929493112038 density:0.333333333333333 bootstrap:0.67747445 cc_score:0.0 bp_score:0.0741441 mf_score:0.161149 relationship: child_of NeXO:6687 ! CC: cell wall part | BP: | MF: [Term] id: NeXO:9032 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.65197749491811 density:0.0218487394957983 bootstrap:0.362889023 cc_score:0.0 bp_score:0.0215383 mf_score:0.0 relationship: child_of NeXO:9745 ! CC: | BP: | MF: [Term] id: NeXO:9033 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.12251664554677 density:0.666666666666667 bootstrap:0.514587851 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9490 ! CC: | BP: | MF: relationship: linked_to NeXO:9014 ! CC: | BP: | MF: [Term] id: NeXO:9030 name: CC: Atg1p signaling complex | BP: | MF: def: "CC_def: A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03114531884645 density:1 bootstrap:0.68360281 cc_score:0.218912 bp_score:0.014992 mf_score:0.0 relationship: child_of NeXO:9691 ! CC: | BP: | MF: relationship: linked_to NeXO:6865 ! CC: | BP: | MF: relationship: linked_to NeXO:8626 ! CC: GSE complex | BP: | MF: [Term] id: NeXO:9031 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.17867412779526 density:0.0199430199430199 bootstrap:0.132030268 cc_score:0.0 bp_score:0.0576673 mf_score:0.0 relationship: child_of NeXO:9722 ! CC: | BP: | MF: [Term] id: NeXO:9037 name: CC: primary cell septum | BP: | MF:mannose-ethanolamine phosphotransferase activity def: "CC_def: A cell septum that forms following nuclear division. | BP_def: | MF_def:Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9730917104409 density:1 bootstrap:0.645084179 cc_score:0.443224 bp_score:0.0 mf_score:0.177397 relationship: child_of NeXO:9514 ! CC: | BP: | MF:dolichyl-phosphate beta-glucosyltransferase activity relationship: linked_to NeXO:8475 ! CC: oligosaccharyltransferase complex | BP: protein N-linked glycosylation via asparagine | MF:dolichyl-diphosphooligosaccharide-protein glycotransferase activity relationship: linked_to NeXO:9365 ! CC: | BP: galactose catabolic process | MF: relationship: linked_to NeXO:9267 ! CC: | BP: | MF: relationship: linked_to NeXO:9170 ! CC: | BP: | MF: [Term] id: NeXO:9035 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03218933491667 density:0.666666666666667 bootstrap:0.376358107 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9489 ! CC: | BP: | MF: [Term] id: NeXO:7016 name: CC: | BP: sulfur amino acid transport | MF:L-methionine secondary active transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.523036615 cc_score:0.0 bp_score:0.222016 mf_score:0.444256 relationship: child_of NeXO:7017 ! CC: | BP: | MF:sulfur amino acid transmembrane transporter activity [Term] id: NeXO:7017 name: CC: | BP: | MF:sulfur amino acid transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [NeXO-GO:term] namespace: NeXO comment: robustness:2.58812673601301 density:0.666666666666667 bootstrap:0.610441454 cc_score:0.0 bp_score:0.0674517 mf_score:0.114535 relationship: child_of NeXO:8378 ! CC: | BP: | MF: [Term] id: NeXO:9038 name: CC: | BP: cytokinesis after mitosis | MF: def: "CC_def: | BP_def: A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54224325 cc_score:0.0891877 bp_score:0.292494 mf_score:0.0 relationship: child_of NeXO:9451 ! CC: | BP: | MF: relationship: linked_to NeXO:7932 ! CC: | BP: | MF: [Term] id: NeXO:7015 name: CC: | BP: positive regulation of translational termination | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of translational termination. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89362446386019 density:1 bootstrap:0.59416841 cc_score:0.0 bp_score:0.29375 mf_score:0.0 relationship: child_of NeXO:7500 ! CC: | BP: translational frameshifting | MF: [Term] id: NeXO:7012 name: CC: Dsl1p complex | BP: endoplasmic reticulum membrane fusion | MF: def: "CC_def: A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p. | BP_def: The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.33312197828975 density:1 bootstrap:0.89102278 cc_score:0.289435 bp_score:0.161436 mf_score:0.0 relationship: child_of NeXO:8878 ! CC: | BP: | MF:SNAP receptor activity [Term] id: NeXO:7011 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.620253397 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8389 ! CC: | BP: | MF: [Term] id: NeXO:5239 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.691876568 cc_score:0.0 bp_score:0.0 mf_score:0.0509091 relationship: child_of NeXO:5447 ! CC: | BP: | MF: [Term] id: NeXO:5230 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85968174 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5439 ! CC: | BP: | MF: [Term] id: NeXO:5231 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89189666 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6983 ! CC: | BP: | MF: [Term] id: NeXO:5232 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.875887341 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6008 ! CC: | BP: | MF:membrane insertase activity [Term] id: NeXO:5233 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.893063661 cc_score:0.0 bp_score:0.0448456 mf_score:0.0 relationship: child_of NeXO:5415 ! CC: GO:0097196 | BP: maintenance of rDNA | MF: [Term] id: NeXO:5234 name: CC: | BP: inosine catabolic process | MF:inosine nucleosidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. | MF_def:Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.55160189 cc_score:0.0 bp_score:0.446667 mf_score:0.443427 relationship: child_of NeXO:5428 ! CC: | BP: guanosine catabolic process | MF:purine-nucleoside phosphorylase activity relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:5235 name: CC: | BP: positive regulation of helicase activity | MF:telomerase inhibitor activity def: "CC_def: | BP_def: Any process that activates or increases the activity of a helicase. | MF_def:Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82177838 cc_score:0.0 bp_score:0.438205 mf_score:0.222541 relationship: child_of NeXO:6219 ! CC: | BP: box C/D snoRNA 3'-end processing | MF:metalloexopeptidase activity [Term] id: NeXO:8598 name: CC: proteasome regulatory particle, lid subcomplex | BP: | MF: def: "CC_def: The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.77889683569228 density:1 bootstrap:0.60807663 cc_score:0.489836 bp_score:0.0824016 mf_score:0.0 relationship: child_of NeXO:9417 ! CC: | BP: | MF: [Term] id: NeXO:8132 name: CC: | BP: | MF:malate dehydrogenase (oxaloacetate-decarboxylating) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.437173263039 density:0.333333333333333 bootstrap:0.418212802 cc_score:0.0 bp_score:0.0 mf_score:0.316381 relationship: child_of NeXO:8839 ! CC: | BP: | MF: [Term] id: NeXO:joining_root name: CC: cellular_component | BP: biological_process | MF:molecular_function def: "CC_def: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. | BP_def: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. | MF_def:Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0.00239346729897251 bootstrap:0.95660572 cc_score:0.540161 bp_score:0.539924 mf_score:0.53906 [Term] id: NeXO:6887 name: CC: Cul3-RING ubiquitin ligase complex | BP: NADP biosynthetic process | MF:NAD+ kinase activity def: "CC_def: A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. | BP_def: The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. | MF_def:Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.512515669 cc_score:0.147168 bp_score:0.220895 mf_score:0.218901 relationship: child_of NeXO:6910 ! CC: | BP: NAD+ kinase activity | MF:NADH kinase activity [Term] id: NeXO:6884 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.818258779 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6885 ! CC: NatA complex | BP: | MF: [Term] id: NeXO:6885 name: CC: NatA complex | BP: | MF: def: "CC_def: A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.93114720971384 density:0.666666666666667 bootstrap:0.78297555 cc_score:0.443106 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7193 ! CC: | BP: | MF: [Term] id: NeXO:6882 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.50655182 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7237 ! CC: | BP: | MF: relationship: linked_to NeXO:9257 ! CC: | BP: | MF: [Term] id: NeXO:6908 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.584829259 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7654 ! CC: | BP: | MF: [Term] id: NeXO:6043 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19171996543935 density:1 bootstrap:0.79596134 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6950 ! CC: | BP: | MF: relationship: linked_to NeXO:8478 ! CC: | BP: | MF:phosphatidylinositol-3,5-bisphosphate binding relationship: linked_to NeXO:6474 ! CC: | BP: | MF: [Term] id: NeXO:6888 name: CC: | BP: lipid glycosylation | MF:sterol 3-beta-glucosyltransferase activity def: "CC_def: | BP_def: Covalent attachment of a glycosyl residue to a lipid molecule. | MF_def:Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58141116 cc_score:0.0 bp_score:0.219816 mf_score:0.441216 relationship: child_of NeXO:7649 ! CC: | BP: | MF: [Term] id: NeXO:6889 name: CC: | BP: protein insertion into mitochondrial membrane | MF: def: "CC_def: | BP_def: The process that results in the incorporation of a protein into a mitochondrial membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97037062163258 density:1 bootstrap:0.643306136 cc_score:0.0 bp_score:0.127028 mf_score:0.0 relationship: child_of NeXO:7046 ! CC: m-AAA complex | BP: | MF: [Term] id: NeXO:5344 name: CC: | BP: nicotinamide mononucleotide transport | MF:nicotinate phosphoribosyltransferase activity def: "CC_def: | BP_def: The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP. | MF_def:Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.2303586015687 density:1 bootstrap:0.82427331 cc_score:0.0 bp_score:0.440221 mf_score:0.440093 relationship: child_of NeXO:6183 ! CC: | BP: nicotinate nucleotide salvage | MF:nicotinamide mononucleotide transmembrane transporter activity [Term] id: NeXO:7168 name: CC: succinate dehydrogenase complex | BP: mitochondrial respiratory chain complex II assembly | MF:oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor def: "CC_def: A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. | BP_def: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane. | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [NeXO-GO:term] namespace: NeXO comment: robustness:7.8979386428651 density:0.714285714285714 bootstrap:0.78323703 cc_score:0.496906 bp_score:0.136439 mf_score:0.446351 relationship: child_of NeXO:7576 ! CC: | BP: | MF:succinate dehydrogenase activity [Term] id: NeXO:7169 name: CC: mitochondrial sorting and assembly machinery complex | BP: mitochondrial outer membrane translocase complex assembly | MF: def: "CC_def: A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex. | BP_def: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9904751287427 density:1 bootstrap:0.656500948 cc_score:0.438954 bp_score:0.259725 mf_score:0.0 relationship: child_of NeXO:8332 ! CC: ERMES complex | BP: protein import into mitochondrial outer membrane | MF: relationship: linked_to NeXO:9102 ! CC: | BP: protein unfolding | MF: relationship: linked_to NeXO:5397 ! CC: | BP: | MF: [Term] id: NeXO:5340 name: CC: | BP: allantoin assimilation pathway | MF:allantoinase activity def: "CC_def: | BP_def: The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP. | MF_def:Catalysis of the reaction: allantoin + H2O = allantoate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76430528 cc_score:0.0 bp_score:0.442808 mf_score:0.446438 relationship: child_of NeXO:5485 ! CC: | BP: uracil transport | MF:uridine transmembrane transporter activity [Term] id: NeXO:5343 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.891224363 cc_score:0.0 bp_score:0.0873793 mf_score:0.0972869 relationship: child_of NeXO:5790 ! CC: | BP: | MF: [Term] id: NeXO:7162 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28214431779065 density:0.0384615384615385 bootstrap:0.74404891 cc_score:0.0 bp_score:0.0462824 mf_score:0.0 relationship: child_of NeXO:8682 ! CC: | BP: | MF: [Term] id: NeXO:7163 name: CC: | BP: | MF:SUMO binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [NeXO-GO:term] namespace: NeXO comment: robustness:2.3008958482593 density:1 bootstrap:0.87723463 cc_score:0.0 bp_score:0.0 mf_score:0.220785 relationship: child_of NeXO:8320 ! CC: | BP: | MF: [Term] id: NeXO:7160 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.302790206 cc_score:0.0 bp_score:0.0108462 mf_score:0.0 relationship: child_of NeXO:8326 ! CC: | BP: | MF: [Term] id: NeXO:7161 name: CC: | BP: | MF:mating pheromone activity def: "CC_def: | BP_def: | MF_def:The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.59240308 cc_score:0.0 bp_score:0.0 mf_score:0.181585 relationship: child_of NeXO:7726 ! CC: | BP: | MF: relationship: linked_to NeXO:6726 ! CC: | BP: | MF: [Term] id: NeXO:7167 name: CC: | BP: | MF:fatty acid synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:6.33630592132554 density:1 bootstrap:0.665247519 cc_score:0.0 bp_score:0.0 mf_score:0.307184 relationship: child_of NeXO:7734 ! CC: | BP: fatty acid biosynthetic process | MF:lipoate biosynthetic process [Term] id: NeXO:7164 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.46886632644015 density:0.666666666666667 bootstrap:0.56134612 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7181 ! CC: | BP: | MF: [Term] id: NeXO:7165 name: CC: | BP: meiotic telomere clustering | MF:G-protein alpha-subunit binding def: "CC_def: | BP_def: The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis. | MF_def:Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83507945 cc_score:0.0 bp_score:0.174189 mf_score:0.291771 relationship: child_of NeXO:8057 ! CC: | BP: | MF: [Term] id: NeXO:8079 name: CC: DNA replication termination region | BP: replication fork progression beyond termination site | MF:DNA topoisomerase (ATP-hydrolyzing) activity def: "CC_def: A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks. | BP_def: Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks. | MF_def:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.685675569 cc_score:0.437766 bp_score:0.292454 mf_score:0.297409 relationship: child_of NeXO:8885 ! CC: DNA topoisomerase complex (ATP-hydrolyzing) | BP: DNA topoisomerase (ATP-hydrolyzing) activity | MF: [Term] id: NeXO:8078 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53515187 cc_score:0.0 bp_score:0.0317087 mf_score:0.0 relationship: child_of NeXO:9017 ! CC: | BP: coenzyme transport | MF:4-hydroxybenzoate octaprenyltransferase activity relationship: linked_to NeXO:8575 ! CC: | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: [Term] id: NeXO:8104 name: CC: | BP: mitochondrial proton-transporting ATP synthase complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.29331295572308 density:1 bootstrap:0.6562505 cc_score:0.0 bp_score:0.223662 mf_score:0.0 relationship: child_of NeXO:8339 ! CC: | BP: | MF: [Term] id: NeXO:8071 name: CC: half bridge of spindle pole body | BP: | MF: def: "CC_def: Structure adjacent to the plaques of the spindle pole body. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.42443814 cc_score:0.441276 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8607 ! CC: | BP: | MF: relationship: linked_to NeXO:8608 ! CC: | BP: | MF: [Term] id: NeXO:8070 name: CC: | BP: | MF:peptidyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7016606642156 density:1 bootstrap:0.479808311 cc_score:0.0 bp_score:0.0 mf_score:0.300616 relationship: child_of NeXO:8172 ! CC: | BP: | MF: relationship: linked_to NeXO:7218 ! CC: | BP: positive regulation of mitochondrial DNA replication | MF: relationship: linked_to NeXO:6794 ! CC: | BP: | MF: relationship: linked_to NeXO:7825 ! CC: | BP: | MF:transferase activity, transferring amino-acyl groups relationship: linked_to NeXO:7824 ! CC: | BP: | MF: [Term] id: NeXO:8073 name: CC: | BP: phosphate transmembrane transport | MF:inorganic phosphate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62639849 cc_score:0.0 bp_score:0.440207 mf_score:0.149647 relationship: child_of NeXO:8914 ! CC: | BP: mannosyl-inositol phosphorylceramide metabolic process | MF:serine C-palmitoyltransferase activity [Term] id: NeXO:8072 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.518996462 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9198 ! CC: | BP: | MF: [Term] id: NeXO:8075 name: CC: | BP: vesicle coating | MF:clathrin binding def: "CC_def: | BP_def: A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. | MF_def:Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69586824 cc_score:0.0 bp_score:0.174806 mf_score:0.20152 relationship: child_of NeXO:8547 ! CC: | BP: | MF: relationship: linked_to NeXO:8407 ! CC: | BP: | MF: [Term] id: NeXO:8077 name: CC: | BP: carbon catabolite activation of transcription from RNA polymerase II promoter | MF: def: "CC_def: | BP_def: Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.8181259166346 density:0.666666666666667 bootstrap:0.723758584 cc_score:0.0 bp_score:0.132969 mf_score:0.0 relationship: child_of NeXO:8769 ! CC: mitochondrial respiratory chain complex III | BP: mitochondrial electron transport, ubiquinol to cytochrome c | MF: [Term] id: NeXO:5649 name: CC: gamma DNA polymerase complex | BP: mitochondrial DNA replication | MF:HDEL sequence binding def: "CC_def: A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. | BP_def: The process in which new strands of DNA are synthesized in the mitochondrion. | MF_def:Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88154303 cc_score:0.439651 bp_score:0.153906 mf_score:0.439221 relationship: child_of NeXO:6089 ! CC: | BP: | MF: [Term] id: NeXO:5648 name: CC: | BP: GO:2001040 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75269846 cc_score:0.0 bp_score:0.219963 mf_score:0.0 relationship: child_of NeXO:5711 ! CC: | BP: | MF: [Term] id: NeXO:8279 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.43358075705562 density:0.444444444444444 bootstrap:0.74777142 cc_score:0.0 bp_score:0.0239905 mf_score:0.0732323 relationship: child_of NeXO:9273 ! CC: | BP: | MF: [Term] id: NeXO:8278 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.80458370522881 density:0.0952380952380952 bootstrap:0.482216636 cc_score:0.0 bp_score:0.0275536 mf_score:0.0 relationship: child_of NeXO:8279 ! CC: | BP: | MF: [Term] id: NeXO:8277 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52654531837488 density:0.333333333333333 bootstrap:0.248744965 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9153 ! CC: | BP: | MF: relationship: linked_to NeXO:6845 ! CC: | BP: | MF: [Term] id: NeXO:8275 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86724789 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:7617 ! CC: | BP: N-glycan processing | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:9365 ! CC: | BP: galactose catabolic process | MF: [Term] id: NeXO:5642 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85835183 cc_score:0.0 bp_score:0.0 mf_score:0.0565249 relationship: child_of NeXO:6569 ! CC: | BP: | MF: [Term] id: NeXO:8273 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.35095932608786 density:0.0384615384615385 bootstrap:0.260735294 cc_score:0.0 bp_score:0.0554951 mf_score:0.0579852 relationship: child_of NeXO:8925 ! CC: | BP: | MF: [Term] id: NeXO:5644 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.728598634 cc_score:0.0 bp_score:0.0985154 mf_score:0.0 relationship: child_of NeXO:5738 ! CC: | BP: | MF:positive regulation of mitotic metaphase/anaphase transition relationship: linked_to NeXO:9144 ! CC: | BP: | MF: [Term] id: NeXO:5647 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8614505 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6412 ! CC: | BP: | MF: [Term] id: NeXO:8270 name: CC: | BP: SRP-dependent cotranslational protein targeting to membrane | MF:signal sequence binding def: "CC_def: | BP_def: The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. | MF_def:Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [NeXO-GO:term] namespace: NeXO comment: robustness:6.81832100155236 density:0.327272727272727 bootstrap:0.61075653 cc_score:0.0 bp_score:0.181226 mf_score:0.111046 relationship: child_of NeXO:8600 ! CC: | BP: cotranslational protein targeting to membrane | MF: [Term] id: NeXO:6334 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7163605 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7175 ! CC: | BP: phospholipid transport | MF:phospholipid transport [Term] id: NeXO:8673 name: CC: | BP: termination of RNA polymerase III transcription | MF: def: "CC_def: | BP_def: The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.855688873338714 density:0.1 bootstrap:0.195609658 cc_score:0.0 bp_score:0.169375 mf_score:0.0 relationship: child_of NeXO:9498 ! CC: | BP: | MF: [Term] id: NeXO:8672 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60938860717171 density:1 bootstrap:0.429184167 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:8667 ! CC: | BP: | MF: [Term] id: NeXO:8670 name: CC: | BP: negative regulation of histone H3-K36 methylation | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7360702166095 density:0.333333333333333 bootstrap:0.61025822 cc_score:0.0 bp_score:0.31667 mf_score:0.0989671 relationship: child_of NeXO:9084 ! CC: | BP: regulation of histone H3-K36 methylation | MF: [Term] id: NeXO:8677 name: CC: | BP: sucrose mediated signaling | MF:bilirubin transmembrane transporter activity def: "CC_def: | BP_def: A series of molecular signals mediated by the detection of sucrose. | MF_def:Catalysis of the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.227649109 cc_score:0.0 bp_score:0.208763 mf_score:0.167335 relationship: child_of NeXO:9320 ! CC: | BP: regulation of nucleosome density | MF: [Term] id: NeXO:8676 name: CC: | BP: traversing start control point of mitotic cell cycle | MF: def: "CC_def: | BP_def: Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.55014135492015 density:1 bootstrap:0.69612859 cc_score:0.0 bp_score:0.110329 mf_score:0.0 relationship: child_of NeXO:9027 ! CC: | BP: | MF: relationship: linked_to NeXO:7342 ! CC: | BP: | MF: [Term] id: NeXO:8674 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.8437879942056 density:0.7 bootstrap:0.62625228 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8679 ! CC: | BP: | MF: [Term] id: NeXO:9511 name: CC: | BP: | MF:Rho GTPase activator activity def: "CC_def: | BP_def: | MF_def:Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [NeXO-GO:term] namespace: NeXO comment: robustness:1.96819344188493 density:0.090909090909091 bootstrap:0.254638536 cc_score:0.065537 bp_score:0.0987311 mf_score:0.176751 relationship: child_of NeXO:9844 ! CC: | BP: | MF:Ras GTPase activator activity [Term] id: NeXO:8679 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12526140216581 density:0.321428571428571 bootstrap:0.44076969 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9644 ! CC: | BP: | MF: [Term] id: NeXO:8678 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.6682053344372 density:1 bootstrap:0.64810884 cc_score:0.0 bp_score:0.0474553 mf_score:0.0 relationship: child_of NeXO:9218 ! CC: | BP: protein import into peroxisome matrix | MF: [Term] id: NeXO:8636 name: CC: | BP: | MF:4-hydroxybenzoate nonaprenyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.57630851510416 density:0.333333333333333 bootstrap:0.50310833 cc_score:0.0 bp_score:0.0 mf_score:0.270897 relationship: child_of NeXO:9017 ! CC: | BP: coenzyme transport | MF:4-hydroxybenzoate octaprenyltransferase activity relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:9699 name: CC: | BP: negative regulation of DNA-dependent DNA replication | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.235135296582 density:0.803030303030303 bootstrap:0.605526554 cc_score:0.0953734 bp_score:0.141169 mf_score:0.0 relationship: child_of NeXO:9855 ! CC: | BP: DNA integrity checkpoint | MF: [Term] id: NeXO:9803 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.74550404654275 density:0.0443548387096774 bootstrap:0.06585987 cc_score:0.0 bp_score:0.0638467 mf_score:0.0341601 relationship: child_of NeXO:9894 ! CC: | BP: | MF: [Term] id: NeXO:8125 name: CC: | BP: ER-dependent peroxisome organization | MF: def: "CC_def: | BP_def: A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.97951555527092 density:1 bootstrap:0.410851783 cc_score:0.0 bp_score:0.22421 mf_score:0.0 relationship: child_of NeXO:8678 ! CC: | BP: | MF: relationship: linked_to NeXO:8433 ! CC: | BP: | MF: [Term] id: NeXO:5735 name: CC: | BP: calcium-mediated signaling | MF:calcium-mediated signaling def: "CC_def: | BP_def: A series of molecular signals in which a cell uses calcium ions to convert a signal into a response. | MF_def:A series of molecular signals in which a cell uses calcium ions to convert a signal into a response." [NeXO-GO:term] namespace: NeXO comment: robustness:5.77000760738341 density:0.533333333333333 bootstrap:0.8422968 cc_score:0.0308182 bp_score:0.273391 mf_score:0.316337 relationship: child_of NeXO:6744 ! CC: | BP: second-messenger-mediated signaling | MF:diacylglycerol kinase activity [Term] id: NeXO:5734 name: CC: | BP: | MF:2 iron, 2 sulfur cluster binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [NeXO-GO:term] namespace: NeXO comment: robustness:2.16796791470775 density:1 bootstrap:0.778802878 cc_score:0.0 bp_score:0.0 mf_score:0.137217 relationship: child_of NeXO:7899 ! CC: | BP: | MF: relationship: linked_to NeXO:6316 ! CC: | BP: regulation of transcription from RNA polymerase II promoter in response to iron | MF: [Term] id: NeXO:5737 name: CC: | BP: isopropylmalate transport | MF:isopropylmalate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of isopropylmalate from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:5.22009834877141 density:0.6 bootstrap:0.88266741 cc_score:0.0 bp_score:0.21619 mf_score:0.215963 relationship: child_of NeXO:7811 ! CC: | BP: | MF: [Term] id: NeXO:8418 name: CC: | BP: cellular response to misfolded protein | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.3775121961825 density:0.9 bootstrap:0.78192767 cc_score:0.0 bp_score:0.150864 mf_score:0.0592725 relationship: child_of NeXO:8919 ! CC: Doa10p ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:5731 name: CC: cortical endoplasmic reticulum | BP: activation of protein kinase activity | MF:D-erythro-sphingosine kinase activity def: "CC_def: A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. | BP_def: Any process that initiates the activity of an inactive protein kinase. | MF_def:Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [NeXO-GO:term] namespace: NeXO comment: robustness:3.24492438796254 density:0.3 bootstrap:0.78989971 cc_score:0.110236 bp_score:0.168214 mf_score:0.309034 relationship: child_of NeXO:5735 ! CC: | BP: calcium-mediated signaling | MF:calcium-mediated signaling [Term] id: NeXO:5730 name: CC: perinuclear endoplasmic reticulum | BP: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway | MF:sphinganine kinase activity def: "CC_def: The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. | BP_def: The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. | MF_def:Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.91325327419613 density:1 bootstrap:0.84581249 cc_score:0.293431 bp_score:0.590759 mf_score:0.588273 relationship: child_of NeXO:5731 ! CC: cortical endoplasmic reticulum | BP: activation of protein kinase activity | MF:D-erythro-sphingosine kinase activity [Term] id: NeXO:5733 name: CC: | BP: | MF:2,4-dienoyl-CoA reductase (NADPH) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20171182332357 density:1 bootstrap:0.803235318 cc_score:0.0 bp_score:0.0 mf_score:0.440879 relationship: child_of NeXO:6831 ! CC: | BP: | MF: relationship: linked_to NeXO:7641 ! CC: | BP: positive regulation of fatty acid metabolic process | MF:catalase activity [Term] id: NeXO:5732 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.28011647293927 density:0.666666666666667 bootstrap:0.85460764 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6772 ! CC: | BP: | MF: [Term] id: NeXO:8413 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20465018109545 density:0.333333333333333 bootstrap:0.293833268 cc_score:0.0 bp_score:0.040599 mf_score:0.0 relationship: child_of NeXO:8980 ! CC: | BP: | MF: relationship: linked_to NeXO:7063 ! CC: | BP: | MF: [Term] id: NeXO:8412 name: CC: signalosome | BP: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion | MF: def: "CC_def: A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. | BP_def: In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.42595731723142 density:0.933333333333333 bootstrap:0.67424612 cc_score:0.661869 bp_score:0.167561 mf_score:0.0 relationship: child_of NeXO:9134 ! CC: | BP: protein modification by small protein removal | MF: [Term] id: NeXO:8411 name: CC: Ctf18 RFC-like complex | BP: maintenance of DNA trinucleotide repeats | MF: def: "CC_def: A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. | BP_def: Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.85583716685836 density:1 bootstrap:0.82117468 cc_score:0.376101 bp_score:0.882661 mf_score:0.0 relationship: child_of NeXO:9625 ! CC: | BP: maintenance of meiotic sister chromatid cohesion | MF: relationship: linked_to NeXO:8067 ! CC: Rad17 RFC-like complex | BP: isopentenyl diphosphate biosynthetic process, mevalonate pathway | MF:DNA clamp loader activity relationship: linked_to NeXO:9121 ! CC: mitotic checkpoint complex | BP: | MF: relationship: linked_to NeXO:9428 ! CC: | BP: DNA replication checkpoint | MF: [Term] id: NeXO:8410 name: CC: | BP: | MF:single-stranded DNA specific exodeoxyribonuclease activity def: "CC_def: | BP_def: | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.09432138542176 density:1 bootstrap:0.726789261 cc_score:0.0 bp_score:0.0792186 mf_score:0.162591 relationship: child_of NeXO:9308 ! CC: Elg1 RFC-like complex | BP: | MF: relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:8067 ! CC: Rad17 RFC-like complex | BP: isopentenyl diphosphate biosynthetic process, mevalonate pathway | MF:DNA clamp loader activity relationship: linked_to NeXO:8481 ! CC: alpha DNA polymerase:primase complex | BP: DNA replication, synthesis of RNA primer | MF:DNA primase activity relationship: linked_to NeXO:8859 ! CC: | BP: base-excision repair, base-free sugar-phosphate removal | MF: relationship: linked_to NeXO:8968 ! CC: | BP: replication fork arrest | MF: relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity [Term] id: NeXO:8417 name: CC: | BP: carotenoid biosynthetic process | MF:dimethylallyltranstransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. | MF_def:Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.85293937445454 density:1 bootstrap:0.568910916 cc_score:0.0 bp_score:0.444779 mf_score:0.294856 relationship: child_of NeXO:8799 ! CC: | BP: terpenoid biosynthetic process | MF:farnesyltranstransferase activity [Term] id: NeXO:5738 name: CC: | BP: | MF:positive regulation of mitotic metaphase/anaphase transition def: "CC_def: | BP_def: | MF_def:Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [NeXO-GO:term] namespace: NeXO comment: robustness:5.71659384364003 density:0.9 bootstrap:0.628258916 cc_score:0.0 bp_score:0.0886999 mf_score:0.11511 relationship: child_of NeXO:6066 ! CC: | BP: mitotic metaphase/anaphase transition | MF: [Term] id: NeXO:8415 name: CC: | BP: GMP biosynthetic process | MF:IMP dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. | MF_def:Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:4.50377881605775 density:0.833333333333333 bootstrap:0.714587678 cc_score:0.0 bp_score:0.247055 mf_score:0.343035 relationship: child_of NeXO:8890 ! CC: | BP: GMP metabolic process | MF: [Term] id: NeXO:8414 name: CC: | BP: glucose mediated signaling pathway | MF:GTPase activating protein binding def: "CC_def: | BP_def: The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. | MF_def:Interacting selectively and non-covalently with a GTPase activating protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.422633579 cc_score:0.0 bp_score:0.147066 mf_score:0.291769 relationship: child_of NeXO:8546 ! CC: | BP: negative regulation of glycogen catabolic process | MF: relationship: linked_to NeXO:8835 ! CC: | BP: regulation of G-protein coupled receptor protein signaling pathway | MF:peptide-methionine (R)-S-oxide reductase activity relationship: linked_to NeXO:6453 ! CC: | BP: | MF: relationship: linked_to NeXO:8133 ! CC: | BP: | MF: [Term] id: NeXO:6468 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.99346942978413 density:1 bootstrap:0.81039425 cc_score:0.0 bp_score:0.0 mf_score:0.0391526 relationship: child_of NeXO:7780 ! CC: | BP: | MF: [Term] id: NeXO:9869 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32316952309206 density:0.0172387490465294 bootstrap:0.085071718 cc_score:0.0 bp_score:0.0283585 mf_score:0.0296757 relationship: child_of NeXO:9954 ! CC: | BP: | MF: [Term] id: NeXO:7588 name: CC: | BP: positive regulation of exocytosis | MF:glutathione biosynthetic process def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of exocytosis. | MF_def:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.228695224 cc_score:0.0 bp_score:0.231136 mf_score:0.198066 relationship: child_of NeXO:8316 ! CC: | BP: leucine metabolic process | MF: [Term] id: NeXO:7589 name: CC: | BP: | MF:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.2177349232743 density:0.833333333333333 bootstrap:0.62670041 cc_score:0.0 bp_score:0.0616373 mf_score:0.199686 relationship: child_of NeXO:7953 ! CC: | BP: 'de novo' IMP biosynthetic process | MF:phosphoribosylformylglycinamidine synthase activity [Term] id: NeXO:9809 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.8540032453972 density:0.473684210526316 bootstrap:0.672664014 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10003 ! CC: cytosolic small ribosomal subunit | BP: | MF: [Term] id: NeXO:9868 name: CC: chromatin silencing complex | BP: progressive alteration of chromatin involved in cell aging | MF:nucleosome binding def: "CC_def: Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. | BP_def: The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. | MF_def:Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [NeXO-GO:term] namespace: NeXO comment: robustness:5.30364519811964 density:0.205882352941176 bootstrap:0.27424831 cc_score:0.119937 bp_score:0.109407 mf_score:0.149677 relationship: child_of NeXO:10013 ! CC: chromosome | BP: chromatin organization | MF:DNA binding [Term] id: NeXO:7584 name: CC: | BP: Golgi vesicle budding | MF: def: "CC_def: | BP_def: The evagination of the Golgi membrane, resulting in formation of a vesicle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.37579381405253 density:0.666666666666667 bootstrap:0.514387533 cc_score:0.0 bp_score:0.204679 mf_score:0.0 relationship: child_of NeXO:8121 ! CC: | BP: | MF: relationship: linked_to NeXO:9046 ! CC: | BP: Golgi inheritance | MF: [Term] id: NeXO:9806 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1597862393474 density:0.138339920948617 bootstrap:0.236260246 cc_score:0.0 bp_score:0.0323345 mf_score:0.0299927 relationship: child_of NeXO:9956 ! CC: | BP: | MF: [Term] id: NeXO:6462 name: CC: integral to cytosolic side of endoplasmic reticulum membrane | BP: vesicle fusion with endoplasmic reticulum | MF: def: "CC_def: Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the cytosol. | BP_def: The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.48690864390474 density:1 bootstrap:0.83141915 cc_score:0.219648 bp_score:0.528274 mf_score:0.0 relationship: child_of NeXO:7012 ! CC: Dsl1p complex | BP: endoplasmic reticulum membrane fusion | MF: [Term] id: NeXO:6463 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.727962875 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7791 ! CC: | BP: | MF: [Term] id: NeXO:7580 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.23670304376888 density:0.0476190476190476 bootstrap:0.507384976 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8267 ! CC: | BP: | MF: [Term] id: NeXO:7581 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53671141 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8567 ! CC: | BP: | MF: [Term] id: NeXO:7582 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.642845785008 density:0.121212121212121 bootstrap:0.269332882 cc_score:0.0 bp_score:0.0 mf_score:0.0362763 relationship: child_of NeXO:8052 ! CC: | BP: | MF: [Term] id: NeXO:6467 name: CC: | BP: cytochrome complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73417803250286 density:0.238095238095238 bootstrap:0.687356692 cc_score:0.0 bp_score:0.247283 mf_score:0.0 relationship: child_of NeXO:6976 ! CC: | BP: | MF: [Term] id: NeXO:7742 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.66484745695666 density:0.733333333333333 bootstrap:0.54228125 cc_score:0.0 bp_score:0.0 mf_score:0.0654583 relationship: child_of NeXO:8364 ! CC: | BP: | MF: relationship: linked_to NeXO:8343 ! CC: | BP: | MF: relationship: linked_to NeXO:8258 ! CC: | BP: | MF:cadmium ion transmembrane transporter activity [Term] id: NeXO:7743 name: CC: | BP: arginine transport | MF:lysine transport def: "CC_def: | BP_def: The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:1.32773895032602 density:0.333333333333333 bootstrap:0.356947592 cc_score:0.0 bp_score:0.204049 mf_score:0.268129 relationship: child_of NeXO:8258 ! CC: | BP: | MF:cadmium ion transmembrane transporter activity relationship: linked_to NeXO:7514 ! CC: | BP: | MF:NADH pyrophosphatase activity relationship: linked_to NeXO:7923 ! CC: | BP: | MF: [Term] id: NeXO:7740 name: CC: | BP: | MF:endodeoxyribonuclease activity, producing 3'-phosphomonoesters def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [NeXO-GO:term] namespace: NeXO comment: robustness:1.29121701088542 density:1 bootstrap:0.276261474 cc_score:0.0 bp_score:0.0 mf_score:0.195383 relationship: child_of NeXO:8496 ! CC: | BP: | MF: relationship: linked_to NeXO:8048 ! CC: lateral element | BP: meiotic recombination checkpoint | MF:SUMO polymer binding [Term] id: NeXO:7741 name: CC: | BP: heme biosynthetic process | MF:coproporphyrinogen oxidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. | MF_def:Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [NeXO-GO:term] namespace: NeXO comment: robustness:3.56673580728962 density:1 bootstrap:0.702651638 cc_score:0.0 bp_score:0.105463 mf_score:0.29772 relationship: child_of NeXO:8166 ! CC: | BP: | MF:5-aminolevulinate synthase activity [Term] id: NeXO:7746 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.500372937 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8162 ! CC: | BP: | MF: [Term] id: NeXO:7747 name: CC: | BP: mitotic anaphase | MF: def: "CC_def: | BP_def: Anaphase occurring as part of mitosis. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.49722282075118 density:0.5 bootstrap:0.80917858 cc_score:0.0 bp_score:0.128302 mf_score:0.0 relationship: child_of NeXO:8608 ! CC: | BP: | MF: [Term] id: NeXO:7744 name: CC: | BP: Group I intron splicing | MF: def: "CC_def: | BP_def: The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.30837935784734 density:0.194444444444444 bootstrap:0.70393633 cc_score:0.0 bp_score:0.207106 mf_score:0.04878 relationship: child_of NeXO:8462 ! CC: | BP: | MF: [Term] id: NeXO:7745 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.486928492 cc_score:0.0 bp_score:0.0129884 mf_score:0.0 relationship: child_of NeXO:8751 ! CC: | BP: | MF: [Term] id: NeXO:5300 name: CC: | BP: | MF:siderophore transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.34559840084183 density:1 bootstrap:0.91165215 cc_score:0.0 bp_score:0.0 mf_score:0.180396 relationship: child_of NeXO:6018 ! CC: high affinity iron permease complex | BP: iron ion transmembrane transport | MF: [Term] id: NeXO:7748 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15780677807331 density:0.666666666666667 bootstrap:0.46518607 cc_score:0.0803272 bp_score:0.0553608 mf_score:0.0 relationship: child_of NeXO:8185 ! CC: | BP: | MF: [Term] id: NeXO:7749 name: CC: | BP: | MF:chorismate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.69261906203096 density:1 bootstrap:0.753125225 cc_score:0.0 bp_score:0.0 mf_score:0.300743 relationship: child_of NeXO:8051 ! CC: | BP: threonine catabolic process | MF:flavin reductase activity [Term] id: NeXO:6524 name: CC: | BP: transsulfuration | MF:L-cysteine desulfhydrase activity def: "CC_def: | BP_def: The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. | MF_def:Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.76904460630153 density:0.238095238095238 bootstrap:0.70025252 cc_score:0.0 bp_score:0.179826 mf_score:0.120397 relationship: child_of NeXO:7184 ! CC: | BP: | MF: [Term] id: NeXO:7483 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.66245882 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9426 ! CC: | BP: | MF: relationship: linked_to NeXO:8563 ! CC: | BP: | MF: [Term] id: NeXO:6914 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.46786504704751 density:0.333333333333333 bootstrap:0.65210468 cc_score:0.0 bp_score:0.088522 mf_score:0.0 relationship: child_of NeXO:7381 ! CC: | BP: | MF: [Term] id: NeXO:5659 name: CC: | BP: | MF:dicarboxylic acid transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82481557 cc_score:0.0 bp_score:0.0 mf_score:0.110516 relationship: child_of NeXO:6117 ! CC: | BP: | MF: [Term] id: NeXO:6723 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99826475529868 density:0.333333333333333 bootstrap:0.80850949 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7942 ! CC: | BP: | MF: [Term] id: NeXO:8306 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.2109893653478 density:0.177777777777778 bootstrap:0.353447978 cc_score:0.0 bp_score:0.0797487 mf_score:0.0 relationship: child_of NeXO:8991 ! CC: | BP: | MF: [Term] id: NeXO:6721 name: CC: signal recognition particle receptor complex | BP: receptor activity | MF:signal recognition particle binding def: "CC_def: A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. | BP_def: Combining with an extracellular or intracellular messenger to initiate a change in cell activity. | MF_def:Interacting selectively and non-covalently with the signal recognition particle." [NeXO-GO:term] namespace: NeXO comment: robustness:3.02620732440632 density:0.666666666666667 bootstrap:0.834584464 cc_score:0.570039 bp_score:0.104773 mf_score:0.571153 relationship: child_of NeXO:7057 ! CC: | BP: phosphatidic acid biosynthetic process | MF: [Term] id: NeXO:8304 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.86685279371561 density:0.833333333333333 bootstrap:0.83444523 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8560 ! CC: | BP: | MF:rRNA (adenine-N6,N6-)-dimethyltransferase activity [Term] id: NeXO:6727 name: CC: | BP: copper ion transport | MF:sodium ion transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:3.96444028880215 density:0.155555555555556 bootstrap:0.63644078 cc_score:0.0 bp_score:0.103264 mf_score:0.211817 relationship: child_of NeXO:7069 ! CC: | BP: potassium ion transport | MF:metal ion transport [Term] id: NeXO:6726 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62433161479029 density:0.266666666666667 bootstrap:0.77531935 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8861 ! CC: | BP: | MF: [Term] id: NeXO:6725 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71228825 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9573 ! CC: mitochondrial large ribosomal subunit | BP: | MF: [Term] id: NeXO:6724 name: CC: | BP: amino acid catabolic process to alcohol via Ehrlich pathway | MF:alcohol dehydrogenase (NAD) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. | MF_def:Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.82752525338038 density:0.666666666666667 bootstrap:0.68342636 cc_score:0.0 bp_score:0.205496 mf_score:0.346553 relationship: child_of NeXO:7432 ! CC: | BP: NADH oxidation | MF: [Term] id: NeXO:6729 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.48928458571102 density:0.1 bootstrap:0.59253487 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7329 ! CC: | BP: | MF: [Term] id: NeXO:6728 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.0903546878617 density:0.238095238095238 bootstrap:0.824734312 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7338 ! CC: | BP: | MF: [Term] id: NeXO:5654 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85476015 cc_score:0.0 bp_score:0.0618432 mf_score:0.0 relationship: child_of NeXO:6781 ! CC: | BP: | MF: relationship: linked_to NeXO:9118 ! CC: | BP: microtubule bundle formation | MF: [Term] id: NeXO:8309 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.3617227721657 density:1 bootstrap:0.307255204 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8943 ! CC: integral to Golgi membrane | BP: | MF: relationship: linked_to NeXO:7068 ! CC: | BP: | MF: [Term] id: NeXO:8308 name: CC: | BP: budding cell isotropic bud growth | MF: def: "CC_def: | BP_def: Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07118492220709 density:1 bootstrap:0.710819934 cc_score:0.0649064 bp_score:0.12638 mf_score:0.0 relationship: child_of NeXO:8872 ! CC: | BP: | MF: [Term] id: NeXO:5820 name: CC: | BP: | MF:citrate hydro-lyase (cis-aconitate-forming) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: citrate = cis-aconitate + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.244259971 cc_score:0.0 bp_score:0.0900137 mf_score:0.139603 relationship: child_of NeXO:6457 ! CC: | BP: | MF:GO:0052723 [Term] id: NeXO:8095 name: CC: | BP: | MF:nucleocytoplasmic transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [NeXO-GO:term] namespace: NeXO comment: robustness:2.76081599660663 density:0.666666666666667 bootstrap:0.69462093 cc_score:0.0 bp_score:0.0 mf_score:0.313289 relationship: child_of NeXO:8304 ! CC: | BP: | MF: [Term] id: NeXO:6953 name: CC: SPOTS complex | BP: regulation of sphingolipid biosynthetic process | MF: def: "CC_def: A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. | BP_def: Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94981249880789 density:0.666666666666667 bootstrap:0.727794142 cc_score:0.536682 bp_score:0.323656 mf_score:0.0923435 relationship: child_of NeXO:8244 ! CC: endoplasmic reticulum palmitoyltransferase complex | BP: | MF: [Term] id: NeXO:5825 name: CC: | BP: | MF:phosphoglycolate phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79973162 cc_score:0.0 bp_score:0.0 mf_score:0.229844 relationship: child_of NeXO:6735 ! CC: | BP: | MF: [Term] id: NeXO:8092 name: CC: | BP: threonine metabolic process | MF:O-phospho-L-serine:2-oxoglutarate aminotransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:9.82076515272143 density:0.904761904761905 bootstrap:0.88218085 cc_score:0.0 bp_score:0.239801 mf_score:0.120253 relationship: child_of NeXO:8523 ! CC: | BP: tryptophan metabolic process | MF:anthranilate synthase activity [Term] id: NeXO:8091 name: CC: | BP: fructose 1,6-bisphosphate 1-phosphatase activity | MF:fructose 1,6-bisphosphate 1-phosphatase activity def: "CC_def: | BP_def: Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. | MF_def:Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.473008902 cc_score:0.0 bp_score:0.4375 mf_score:0.440056 relationship: child_of NeXO:8895 ! CC: | BP: | MF: relationship: linked_to NeXO:5425 ! CC: | BP: | MF: relationship: linked_to NeXO:6999 ! CC: mitochondrial respiratory chain complex II | BP: mitochondrial electron transport, succinate to ubiquinone | MF:succinate dehydrogenase (ubiquinone) activity [Term] id: NeXO:8090 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.253918142 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8356 ! CC: TORC1 complex | BP: | MF: [Term] id: NeXO:5828 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.849352207 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7441 ! CC: | BP: | MF:actin lateral binding [Term] id: NeXO:8099 name: CC: CBF3 complex | BP: | MF:centromeric DNA binding def: "CC_def: A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p. | BP_def: | MF_def:Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [NeXO-GO:term] namespace: NeXO comment: robustness:3.76604864085616 density:1 bootstrap:0.78337558 cc_score:0.350595 bp_score:0.0 mf_score:0.219181 relationship: child_of NeXO:9093 ! CC: | BP: | MF: relationship: linked_to NeXO:9548 ! CC: | BP: | MF: [Term] id: NeXO:7488 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.68672728555185 density:1 bootstrap:0.750723837 cc_score:0.0 bp_score:0.0906445 mf_score:0.0 relationship: child_of NeXO:8723 ! CC: | BP: bipolar cellular bud site selection | MF: [Term] id: NeXO:9939 name: CC: cytoplasmic mRNA processing body | BP: mRNA catabolic process | MF: def: "CC_def: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. | BP_def: The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.5514670700495 density:0.718954248366013 bootstrap:0.475676818 cc_score:0.187276 bp_score:0.102683 mf_score:0.0 relationship: child_of NeXO:9985 ! CC: U2-type spliceosomal complex | BP: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | MF: [Term] id: NeXO:5650 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84670941 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6768 ! CC: | BP: | MF: [Term] id: NeXO:9933 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.2329083978605 density:0.0604244694132335 bootstrap:0.225190536 cc_score:0.0519153 bp_score:0.0750613 mf_score:0.0524974 relationship: child_of NeXO:9981 ! CC: endosome | BP: vesicle-mediated transport | MF:protein transport [Term] id: NeXO:9932 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.63785597956 density:0.0112378976486860 bootstrap:0.125803883 cc_score:0.0259698 bp_score:0.0343905 mf_score:0.0290449 relationship: child_of NeXO:9977 ! CC: | BP: | MF: [Term] id: NeXO:9931 name: CC: | BP: regulation of protein kinase activity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of protein kinase activity. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.2152083150022 density:0.124935995903738 bootstrap:0.31571621 cc_score:0.0889832 bp_score:0.141778 mf_score:0.0976396 relationship: child_of NeXO:10025 ! CC: cytoskeleton | BP: mitotic cell cycle | MF:cell cycle [Term] id: NeXO:9930 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.04583157316192 density:0.0185590657908456 bootstrap:0.076285967 cc_score:0.0 bp_score:0.0511946 mf_score:0.0271257 relationship: child_of NeXO:9978 ! CC: | BP: | MF: [Term] id: NeXO:9937 name: CC: | BP: vacuole organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.2388070021297 density:0.123215230037017 bootstrap:0.178230496 cc_score:0.0616046 bp_score:0.106773 mf_score:0.0660465 relationship: child_of NeXO:9941 ! CC: | BP: post-Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9934 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.38391769181867 density:0.0493506493506494 bootstrap:0.070463847 cc_score:0.0 bp_score:0.0476572 mf_score:0.0386441 relationship: child_of NeXO:9983 ! CC: | BP: | MF: [Term] id: NeXO:6916 name: CC: | BP: | MF:protein disulfide oxidoreductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [NeXO-GO:term] namespace: NeXO comment: robustness:3.89073112501562 density:0.222222222222222 bootstrap:0.486506514 cc_score:0.0 bp_score:0.0582176 mf_score:0.143555 relationship: child_of NeXO:8024 ! CC: | BP: | MF:intramolecular oxidoreductase activity [Term] id: NeXO:6958 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90465501350315 density:0.0384615384615385 bootstrap:0.518260278 cc_score:0.0 bp_score:0.0589413 mf_score:0.0 relationship: child_of NeXO:8533 ! CC: | BP: | MF: [Term] id: NeXO:9964 name: CC: Golgi apparatus part | BP: vesicle fusion | MF: def: "CC_def: Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. | BP_def: Fusion of the membrane of a transport vesicle with its target membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.0576419896782 density:0.0635544635544636 bootstrap:0.198274035 cc_score:0.128241 bp_score:0.142455 mf_score:0.0614244 relationship: child_of NeXO:9965 ! CC: Golgi apparatus | BP: Golgi vesicle transport | MF: [Term] id: NeXO:6099 name: CC: | BP: cytidine deamination | MF:cytidine deaminase activity def: "CC_def: | BP_def: The removal of amino group in the presence of water. | MF_def:Catalysis of the reaction: cytidine + H2O = uridine + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74686871 cc_score:0.0 bp_score:0.316727 mf_score:0.314749 relationship: child_of NeXO:6100 ! CC: | BP: deoxycytidine catabolic process | MF: [Term] id: NeXO:9147 name: CC: spindle midzone | BP: mitotic spindle stabilization | MF: def: "CC_def: The area in the center of the spindle where the spindle microtubules from opposite poles overlap. | BP_def: The cell cycle process in which spindle integrity is maintained during M phase of mitosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.56555579784387 density:0.333333333333333 bootstrap:0.261620636 cc_score:0.15662 bp_score:0.166428 mf_score:0.0 relationship: child_of NeXO:9420 ! CC: kinetochore microtubule | BP: regulation of cell division | MF: [Term] id: NeXO:8261 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53385675 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8457 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: relationship: linked_to NeXO:8752 ! CC: Noc4p-Nop14p complex | BP: | MF: [Term] id: NeXO:6092 name: CC: | BP: cobalt ion transport | MF:cobalt ion transport def: "CC_def: | BP_def: The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:1.88830005624296 density:0.166666666666667 bootstrap:0.83913389 cc_score:0.0 bp_score:0.365345 mf_score:0.350421 relationship: child_of NeXO:6136 ! CC: | BP: cellular zinc ion homeostasis | MF:ribosylnicotinamide kinase activity [Term] id: NeXO:8631 name: CC: extrachromosomal circular DNA | BP: 2-micrometer plasmid partitioning | MF: def: "CC_def: Circular DNA structures that are not part of a chromosome. | BP_def: The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52860466698343 density:0.333333333333333 bootstrap:0.473117952 cc_score:0.230173 bp_score:0.156132 mf_score:0.0 relationship: child_of NeXO:9176 ! CC: | BP: | MF: [Term] id: NeXO:6097 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89924312243821 density:0.166666666666667 bootstrap:0.84888796 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7133 ! CC: | BP: | MF: [Term] id: NeXO:8124 name: CC: mitotic spindle | BP: | MF: def: "CC_def: A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23214181362792 density:0.2 bootstrap:0.60202515 cc_score:0.128537 bp_score:0.0 mf_score:0.0659394 relationship: child_of NeXO:8516 ! CC: | BP: | MF: [Term] id: NeXO:6657 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.626439194 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7573 ! CC: Ssh1 translocon complex | BP: | MF: relationship: linked_to NeXO:9180 ! CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: [Term] id: NeXO:6656 name: CC: | BP: ceramide catabolic process | MF:dihydroceramidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. | MF_def:Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.21413987239551 density:1 bootstrap:0.81232899 cc_score:0.0 bp_score:0.295471 mf_score:0.443716 relationship: child_of NeXO:7182 ! CC: | BP: sphingolipid catabolic process | MF:ceramidase activity relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity [Term] id: NeXO:6655 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11131524259575 density:1 bootstrap:0.73863182 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7632 ! CC: | BP: pyruvate transport | MF: [Term] id: NeXO:6654 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82595985 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7670 ! CC: | BP: | MF: relationship: linked_to NeXO:9496 ! CC: integral to endosome membrane | BP: Golgi to plasma membrane protein transport | MF: [Term] id: NeXO:6653 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62940902 cc_score:0.0 bp_score:0.019817 mf_score:0.0 relationship: child_of NeXO:7208 ! CC: | BP: | MF: [Term] id: NeXO:6652 name: CC: eukaryotic translation elongation factor 1 complex | BP: | MF: def: "CC_def: A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.24709960539467 density:1 bootstrap:0.83669369 cc_score:0.350057 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7130 ! CC: | BP: | MF: [Term] id: NeXO:6651 name: CC: | BP: regulation of glycogen catabolic process | MF:phosphatidate phosphatase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. | MF_def:Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.705491807 cc_score:0.0 bp_score:0.222176 mf_score:0.219154 relationship: child_of NeXO:7296 ! CC: | BP: positive regulation of phospholipid translocation | MF: [Term] id: NeXO:6650 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89647282 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7799 ! CC: | BP: | MF: [Term] id: NeXO:5919 name: CC: mRNA cap binding complex | BP: positive regulation of cytoplasmic mRNA processing body assembly | MF: def: "CC_def: Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. | BP_def: Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33656564975256 density:1 bootstrap:0.90464424 cc_score:0.225058 bp_score:0.43851 mf_score:0.0 relationship: child_of NeXO:7236 ! CC: | BP: | MF: [Term] id: NeXO:5918 name: CC: | BP: pentose-phosphate shunt, non-oxidative branch | MF:ribose-5-phosphate isomerase activity def: "CC_def: | BP_def: The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. | MF_def:Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90528924 cc_score:0.0 bp_score:0.439452 mf_score:0.442981 relationship: child_of NeXO:6450 ! CC: | BP: establishment of mitochondrion localization | MF: [Term] id: NeXO:5915 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21072276286201 density:1 bootstrap:0.80982357 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5916 ! CC: | BP: | MF: [Term] id: NeXO:5914 name: CC: | BP: negative regulation of telomere maintenance via telomerase | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62099317357043 density:0.5 bootstrap:0.86746744 cc_score:0.0 bp_score:0.116267 mf_score:0.0 relationship: child_of NeXO:6599 ! CC: | BP: | MF: [Term] id: NeXO:5917 name: CC: | BP: farnesyl diphosphate biosynthetic process, mevalonate pathway | MF:mevalonate kinase activity def: "CC_def: | BP_def: The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. | MF_def:Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.27848117540776 density:1 bootstrap:0.86022634 cc_score:0.0 bp_score:0.295292 mf_score:0.437666 relationship: child_of NeXO:7751 ! CC: | BP: | MF: relationship: linked_to NeXO:9057 ! CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [Term] id: NeXO:5916 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03401675331661 density:0.333333333333333 bootstrap:0.83769923 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7103 ! CC: | BP: nucleotide-excision repair, DNA incision, 3'-to lesion | MF: [Term] id: NeXO:5911 name: CC: | BP: mitochondrial electron transport, NADH to ubiquinone | MF:NADH dehydrogenase (ubiquinone) activity def: "CC_def: | BP_def: The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. | MF_def:Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20432709454364 density:1 bootstrap:0.805144674 cc_score:0.0 bp_score:0.438949 mf_score:0.595747 relationship: child_of NeXO:6194 ! CC: | BP: positive regulation of apoptosis | MF:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: NeXO:5910 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01439171441817 density:1 bootstrap:0.672372124 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6697 ! CC: | BP: | MF: [Term] id: NeXO:5912 name: CC: | BP: snoRNA transcription from an RNA polymerase II promoter | MF:chromatin insulator sequence binding def: "CC_def: | BP_def: The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. | MF_def:Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80138 cc_score:0.0 bp_score:0.17927 mf_score:0.442787 relationship: child_of NeXO:5914 ! CC: | BP: negative regulation of telomere maintenance via telomerase | MF: [Term] id: NeXO:8364 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.0478843202182 density:0.705627705627706 bootstrap:0.66294106 cc_score:0.0 bp_score:0.0196926 mf_score:0.0353136 relationship: child_of NeXO:9154 ! CC: | BP: | MF: [Term] id: NeXO:6385 name: CC: 3-isopropylmalate dehydratase complex | BP: | MF:3-isopropylmalate dehydratase activity def: "CC_def: A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. | BP_def: | MF_def:Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7909334570143 density:1 bootstrap:0.531472437 cc_score:0.437832 bp_score:0.0 mf_score:0.439297 relationship: child_of NeXO:6730 ! CC: | BP: | MF:ketol-acid reductoisomerase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:6384 name: CC: | BP: | MF:beta-glucosidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:4.17789041478164 density:0.214285714285714 bootstrap:0.745407323 cc_score:0.0 bp_score:0.0 mf_score:0.209301 relationship: child_of NeXO:7439 ! CC: | BP: | MF: [Term] id: NeXO:6387 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.763380875 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7849 ! CC: | BP: | MF: [Term] id: NeXO:6386 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79817820079017 density:0.166666666666667 bootstrap:0.76094752 cc_score:0.0 bp_score:0.0850355 mf_score:0.0 relationship: child_of NeXO:7461 ! CC: | BP: | MF: [Term] id: NeXO:6381 name: CC: | BP: urea metabolic process | MF:ornithine carbamoyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. | MF_def:Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [NeXO-GO:term] namespace: NeXO comment: robustness:1.78494931363511 density:0.2 bootstrap:0.384966417 cc_score:0.0 bp_score:0.205906 mf_score:0.136519 relationship: child_of NeXO:7087 ! CC: | BP: polyamine metabolic process | MF: [Term] id: NeXO:6380 name: CC: | BP: | MF:acetylglucosaminyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [NeXO-GO:term] namespace: NeXO comment: robustness:3.24519732970139 density:0.5 bootstrap:0.696754834 cc_score:0.0 bp_score:0.0 mf_score:0.203853 relationship: child_of NeXO:7217 ! CC: | BP: | MF: [Term] id: NeXO:6383 name: CC: | BP: | MF:glucan exo-1,3-beta-glucosidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [NeXO-GO:term] namespace: NeXO comment: robustness:4.11163561506918 density:0.666666666666667 bootstrap:0.788650957 cc_score:0.0 bp_score:0.0334037 mf_score:0.497781 relationship: child_of NeXO:6384 ! CC: | BP: | MF:beta-glucosidase activity [Term] id: NeXO:6382 name: CC: | BP: glutamate decarboxylation to succinate | MF:4-aminobutyrate transaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. | MF_def:Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20269837992371 density:0.333333333333333 bootstrap:0.517898866 cc_score:0.0 bp_score:0.203013 mf_score:0.200964 relationship: child_of NeXO:6476 ! CC: | BP: proline transport | MF:glutathione peroxidase activity [Term] id: NeXO:6389 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.676925105 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7745 ! CC: | BP: | MF: [Term] id: NeXO:6388 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.88829318471208 density:0.833333333333333 bootstrap:0.84181354 cc_score:0.0 bp_score:0.0360491 mf_score:0.0 relationship: child_of NeXO:9195 ! CC: | BP: regulation of S phase | MF: [Term] id: NeXO:8588 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.195040136 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9343 ! CC: | BP: | MF: [Term] id: NeXO:8881 name: CC: | BP: regulation of intracellular lipid transport | MF:FFAT motif binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. | MF_def:Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83920032 cc_score:0.0 bp_score:0.441033 mf_score:0.441311 relationship: child_of NeXO:9342 ! CC: | BP: negative regulation of transcription factor import into nucleus | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9668 ! CC: | BP: microtubule depolymerization | MF: [Term] id: NeXO:9851 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.8911528572006 density:0.816176470588235 bootstrap:0.415555609 cc_score:0.0 bp_score:0.0538173 mf_score:0.0 relationship: child_of NeXO:10003 ! CC: cytosolic small ribosomal subunit | BP: | MF: relationship: linked_to NeXO:9904 ! CC: | BP: | MF: [Term] id: NeXO:8748 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66949573478279 density:1 bootstrap:0.461840989 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: relationship: linked_to NeXO:8983 ! CC: | BP: | MF: relationship: linked_to NeXO:9484 ! CC: | BP: | MF: [Term] id: NeXO:9154 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.1921632080235 density:0.566951566951567 bootstrap:0.671645873 cc_score:0.0 bp_score:0.0270171 mf_score:0.0 relationship: child_of NeXO:9425 ! CC: | BP: | MF: [Term] id: NeXO:9156 name: CC: nuclear replisome | BP: DNA synthesis involved in DNA repair | MF: def: "CC_def: A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. | BP_def: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.4229070335395 density:0.666666666666667 bootstrap:0.561700618 cc_score:0.164256 bp_score:0.201314 mf_score:0.0404564 relationship: child_of NeXO:9467 ! CC: | BP: DNA replication, removal of RNA primer | MF: [Term] id: NeXO:9151 name: CC: | BP: mitotic chromosome condensation | MF: def: "CC_def: | BP_def: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.90098397347609 density:0.196969696969697 bootstrap:0.317520046 cc_score:0.0 bp_score:0.270398 mf_score:0.0 relationship: child_of NeXO:9565 ! CC: condensed nuclear chromosome | BP: chromosome condensation | MF: [Term] id: NeXO:9150 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.4253934000505 density:0.688888888888889 bootstrap:0.80933243 cc_score:0.0 bp_score:0.0208313 mf_score:0.0 relationship: child_of NeXO:9532 ! CC: | BP: | MF: [Term] id: NeXO:9153 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.04306501094021 density:0.138095238095238 bootstrap:0.52959253 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9367 ! CC: | BP: | MF: [Term] id: NeXO:9152 name: CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: def: "CC_def: A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. | BP_def: Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.7555644464599 density:1 bootstrap:0.62455215 cc_score:0.531804 bp_score:0.133846 mf_score:0.0 relationship: child_of NeXO:9886 ! CC: condensed nuclear chromosome kinetochore | BP: mitotic sister chromatid cohesion | MF: relationship: linked_to NeXO:9494 ! CC: checkpoint clamp complex | BP: mitotic cell cycle G1/S transition checkpoint | MF:exodeoxyribonuclease III activity relationship: linked_to NeXO:9548 ! CC: | BP: | MF: [Term] id: NeXO:8667 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.591346183 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9083 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: [Term] id: NeXO:9159 name: CC: COPI coated vesicle membrane | BP: | MF: def: "CC_def: The lipid bilayer surrounding a COPI-coated vesicle. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.15563812914395 density:0.666666666666667 bootstrap:0.723746948 cc_score:0.322433 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9718 ! CC: Golgi-associated vesicle membrane | BP: retrograde vesicle-mediated transport, Golgi to ER | MF: [Term] id: NeXO:9158 name: CC: | BP: | MF:mRNA 5'-UTR binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.162534946796 density:1 bootstrap:0.223941138 cc_score:0.0 bp_score:0.038511 mf_score:0.438214 relationship: child_of NeXO:9497 ! CC: | BP: signal transduction involved in meiotic recombination checkpoint | MF:translation repressor activity, nucleic acid binding relationship: linked_to NeXO:8651 ! CC: | BP: | MF:phosphatase activator activity relationship: linked_to NeXO:8359 ! CC: | BP: | MF:acetyl-CoA C-acyltransferase activity relationship: linked_to NeXO:8887 ! CC: | BP: | MF: [Term] id: NeXO:7908 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.00073180476231 density:0.5 bootstrap:0.595733652 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8723 ! CC: | BP: bipolar cellular bud site selection | MF: [Term] id: NeXO:7909 name: CC: | BP: regulation of phosphoprotein phosphatase activity | MF:protein phosphatase binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. | MF_def:Interacting selectively and non-covalently with any protein phosphatase." [NeXO-GO:term] namespace: NeXO comment: robustness:1.11382047627857 density:0.0357142857142857 bootstrap:0.45360502 cc_score:0.0 bp_score:0.135255 mf_score:0.142586 relationship: child_of NeXO:8366 ! CC: protein serine/threonine phosphatase complex | BP: glucan biosynthetic process | MF:protein phosphatase type 1 regulator activity [Term] id: NeXO:9489 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.6226683622721 density:0.8 bootstrap:0.480434349 cc_score:0.0 bp_score:0.0432879 mf_score:0.0 relationship: child_of NeXO:9725 ! CC: | BP: | MF: [Term] id: NeXO:9488 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.49006163465475 density:0.0519480519480520 bootstrap:0.222439146 cc_score:0.0 bp_score:0.0279633 mf_score:0.0 relationship: child_of NeXO:9827 ! CC: | BP: | MF: [Term] id: NeXO:7900 name: CC: | BP: lipopolysaccharide biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.94237252811843 density:0.666666666666667 bootstrap:0.788984105 cc_score:0.0 bp_score:0.313121 mf_score:0.0 relationship: child_of NeXO:8415 ! CC: | BP: GMP biosynthetic process | MF:IMP dehydrogenase activity [Term] id: NeXO:7901 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6887371545469 density:0.0392156862745098 bootstrap:0.219248656 cc_score:0.0 bp_score:0.0553023 mf_score:0.0 relationship: child_of NeXO:8906 ! CC: | BP: | MF: [Term] id: NeXO:7902 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64402480553696 density:0.3 bootstrap:0.524437625 cc_score:0.0 bp_score:0.0170408 mf_score:0.0 relationship: child_of NeXO:8879 ! CC: | BP: response to organic nitrogen | MF: [Term] id: NeXO:7903 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.66288917995432 density:0.238095238095238 bootstrap:0.66136268 cc_score:0.0 bp_score:0.0441427 mf_score:0.0 relationship: child_of NeXO:9274 ! CC: | BP: | MF: [Term] id: NeXO:7904 name: CC: | BP: | MF:ubiquitin-protein ligase regulator activity def: "CC_def: | BP_def: | MF_def:Modulates the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.217585938 cc_score:0.0593352 bp_score:0.0654919 mf_score:0.141022 relationship: child_of NeXO:8453 ! CC: | BP: protein autophosphorylation | MF: [Term] id: NeXO:7905 name: CC: | BP: glutathione biosynthetic process | MF:glutathione synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. | MF_def:Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:5.00310979937335 density:0.428571428571429 bootstrap:0.599531888 cc_score:0.0 bp_score:0.126275 mf_score:0.150962 relationship: child_of NeXO:8216 ! CC: | BP: | MF: [Term] id: NeXO:8747 name: CC: | BP: error-free postreplication DNA repair | MF:four-way junction DNA binding def: "CC_def: | BP_def: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions and but does not increase the endogenous mutation rate. | MF_def:Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [NeXO-GO:term] namespace: NeXO comment: robustness:1.29015937108128 density:0.333333333333333 bootstrap:0.337027848 cc_score:0.0 bp_score:0.236122 mf_score:0.103214 relationship: child_of NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:7182 ! CC: | BP: sphingolipid catabolic process | MF:ceramidase activity relationship: linked_to NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: [Term] id: NeXO:7907 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62198460025389 density:0.0380952380952381 bootstrap:0.293848843 cc_score:0.0 bp_score:0.0495076 mf_score:0.0497893 relationship: child_of NeXO:8637 ! CC: | BP: | MF: [Term] id: NeXO:6270 name: CC: | BP: tripeptide transport | MF:tripeptide transporter activity def: "CC_def: | BP_def: The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82325982 cc_score:0.0 bp_score:0.233232 mf_score:0.443694 relationship: child_of NeXO:6825 ! CC: | BP: response to amino acid stimulus | MF:dipeptide transporter activity [Term] id: NeXO:6273 name: CC: | BP: biofilm formation | MF: def: "CC_def: | BP_def: A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.65361894 cc_score:0.0 bp_score:0.125431 mf_score:0.0 relationship: child_of NeXO:7107 ! CC: | BP: | MF: [Term] id: NeXO:6272 name: CC: | BP: mRNA stabilization | MF: def: "CC_def: | BP_def: Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56515621 cc_score:0.0 bp_score:0.127648 mf_score:0.0 relationship: child_of NeXO:6803 ! CC: | BP: organelle membrane fusion | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:6275 name: CC: | BP: positive regulation of chromatin silencing at silent mating-type cassette | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93430065069257 density:1 bootstrap:0.619968755 cc_score:0.0 bp_score:0.441962 mf_score:0.0 relationship: child_of NeXO:6521 ! CC: | BP: negative regulation of transcription elongation from RNA polymerase II promoter | MF:glycine dehydrogenase (decarboxylating) activity [Term] id: NeXO:7304 name: CC: | BP: | MF:3-hydroxyanthranilate 3,4-dioxygenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.64059109714194 density:1 bootstrap:0.73205209 cc_score:0.0 bp_score:0.0 mf_score:0.293771 relationship: child_of NeXO:8209 ! CC: | BP: | MF: [Term] id: NeXO:6277 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99468684676833 density:0.333333333333333 bootstrap:0.805616797 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6607 ! CC: | BP: | MF: [Term] id: NeXO:6276 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86954161 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6277 ! CC: | BP: | MF: [Term] id: NeXO:6279 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77756379 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6702 ! CC: | BP: | MF: [Term] id: NeXO:6278 name: CC: SUMO activating enzyme complex | BP: | MF:SUMO activating enzyme activity def: "CC_def: A conserved heterodimeric complex with SUMO activating enzyme activity. | BP_def: | MF_def:Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.66372414 cc_score:0.29172 bp_score:0.0 mf_score:0.296781 relationship: child_of NeXO:7424 ! CC: | BP: cellular age-dependent response to reactive oxygen species | MF: [Term] id: NeXO:8861 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.87978327827426 density:0.136363636363636 bootstrap:0.275478292 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9140 ! CC: | BP: | MF: [Term] id: NeXO:6077 name: CC: | BP: mitochondrial lysyl-tRNA aminoacylation | MF: def: "CC_def: | BP_def: The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.72061286184607 density:0.166666666666667 bootstrap:0.696715671 cc_score:0.0 bp_score:0.254331 mf_score:0.0 relationship: child_of NeXO:6400 ! CC: | BP: | MF: [Term] id: NeXO:6076 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78618807 cc_score:0.0 bp_score:0.0577684 mf_score:0.0 relationship: child_of NeXO:6875 ! CC: | BP: | MF: [Term] id: NeXO:6075 name: CC: | BP: | MF:ADP-ribose diphosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.83018160738108 density:0.333333333333333 bootstrap:0.85499486 cc_score:0.0 bp_score:0.0 mf_score:0.229463 relationship: child_of NeXO:6137 ! CC: | BP: | MF: [Term] id: NeXO:6074 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.61238094100401 density:0.1 bootstrap:0.69453452 cc_score:0.0 bp_score:0.0906892 mf_score:0.0 relationship: child_of NeXO:6436 ! CC: | BP: | MF:glycerol-3-phosphate O-acyltransferase activity [Term] id: NeXO:6072 name: CC: | BP: | MF:ornithine metabolic process def: "CC_def: | BP_def: | MF_def:The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.713710197 cc_score:0.0 bp_score:0.0 mf_score:0.131828 relationship: child_of NeXO:6325 ! CC: mitochondrial ribonuclease P complex | BP: | MF: [Term] id: NeXO:6071 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99921516798433 density:0.0952380952380952 bootstrap:0.591843936 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6909 ! CC: | BP: cellular response to metal ion | MF: [Term] id: NeXO:6070 name: CC: | BP: galactose catabolic process via UDP-galactose | MF:aldose 1-epimerase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. | MF_def:Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [NeXO-GO:term] namespace: NeXO comment: robustness:4.08033353003439 density:1 bootstrap:0.91957998 cc_score:0.0 bp_score:0.456929 mf_score:0.298257 relationship: child_of NeXO:7055 ! CC: | BP: galactose metabolic process | MF:UDP-glucose 4-epimerase activity [Term] id: NeXO:9551 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.0493086501672 density:0.833333333333333 bootstrap:0.32757005 cc_score:0.0 bp_score:0.0546102 mf_score:0.0 relationship: child_of NeXO:9774 ! CC: | BP: regulation of protein desumoylation | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:9550 name: CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: | BP_def: Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.84177459418737 density:1 bootstrap:0.446043725 cc_score:0.0 bp_score:0.292739 mf_score:0.0 relationship: child_of NeXO:9741 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: relationship: linked_to NeXO:9524 ! CC: | BP: | MF: relationship: linked_to NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:9505 ! CC: | BP: | MF: relationship: linked_to NeXO:8456 ! CC: | BP: | MF: relationship: linked_to NeXO:8786 ! CC: | BP: | MF: relationship: linked_to NeXO:9587 ! CC: | BP: | MF: [Term] id: NeXO:9553 name: CC: extrinsic to internal side of plasma membrane | BP: regulation of nitrogen utilization | MF: def: "CC_def: Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region. | BP_def: Any process that modulates the frequency, rate or extent of nitrogen utilization. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.60391642082063 density:0.355555555555556 bootstrap:0.305266591 cc_score:0.138931 bp_score:0.164112 mf_score:0.0 relationship: child_of NeXO:9782 ! CC: | BP: | MF: [Term] id: NeXO:9552 name: CC: nuclear membrane | BP: nuclear pore organization | MF: def: "CC_def: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.0748350398943 density:0.56140350877193 bootstrap:0.626656912 cc_score:0.136141 bp_score:0.335032 mf_score:0.0 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport [Term] id: NeXO:9555 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.13442398705343 density:0.0833333333333333 bootstrap:0.138514678 cc_score:0.0 bp_score:0.0111118 mf_score:0.0 relationship: child_of NeXO:9969 ! CC: | BP: | MF: [Term] id: NeXO:9554 name: CC: | BP: TOR signaling cascade | MF: def: "CC_def: | BP_def: A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.90158756493782 density:0.228571428571429 bootstrap:0.167324093 cc_score:0.0 bp_score:0.20371 mf_score:0.0 relationship: child_of NeXO:9746 ! CC: | BP: | MF: [Term] id: NeXO:6079 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.833152698 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6402 ! CC: membrane raft | BP: | MF:FMN binding [Term] id: NeXO:6078 name: CC: | BP: | MF:voltage-gated cation channel activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:3.54115853173344 density:0.5 bootstrap:0.82963776 cc_score:0.0 bp_score:0.0 mf_score:0.165278 relationship: child_of NeXO:6136 ! CC: | BP: cellular zinc ion homeostasis | MF:ribosylnicotinamide kinase activity [Term] id: NeXO:9731 name: CC: nuclear ubiquitin ligase complex | BP: | MF: def: "CC_def: A ubiquitin ligase complex found in the nucleus. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.8187404100304 density:0.192513368983957 bootstrap:0.30688559 cc_score:0.27231 bp_score:0.0874827 mf_score:0.0773114 relationship: child_of NeXO:9824 ! CC: | BP: | MF: [Term] id: NeXO:9730 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.19940255069078 density:0.0221774193548387 bootstrap:0.085683204 cc_score:0.0 bp_score:0.0203795 mf_score:0.0 relationship: child_of NeXO:9883 ! CC: large ribosomal subunit | BP: cellular monovalent inorganic cation homeostasis | MF: [Term] id: NeXO:9733 name: CC: trans spliceosomal complex | BP: spliceosomal snRNP assembly | MF: def: "CC_def: A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates. | BP_def: The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.34948900545647 density:1 bootstrap:0.689690386 cc_score:0.139492 bp_score:0.17357 mf_score:0.0937397 relationship: child_of NeXO:9984 ! CC: catalytic step 1 spliceosome | BP: nuclear mRNA splicing, via spliceosome | MF: relationship: linked_to NeXO:9829 ! CC: U4/U6 x U5 tri-snRNP complex | BP: | MF: relationship: linked_to NeXO:9179 ! CC: | BP: | MF: [Term] id: NeXO:7309 name: CC: | BP: positive regulation of protein dephosphorylation | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.48013262 cc_score:0.0 bp_score:0.162389 mf_score:0.0 relationship: child_of NeXO:8365 ! CC: | BP: RNA capping | MF: [Term] id: NeXO:9735 name: CC: endosomal part | BP: regulation of vacuole fusion, non-autophagic | MF: def: "CC_def: Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. | BP_def: Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.7014198467837 density:0.358695652173913 bootstrap:0.585721342 cc_score:0.112458 bp_score:0.179825 mf_score:0.0910853 relationship: child_of NeXO:9837 ! CC: cis-Golgi network | BP: Golgi to vacuole transport | MF:Ras guanyl-nucleotide exchange factor activity [Term] id: NeXO:9737 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.59555451032663 density:0.032258064516129 bootstrap:0.087020244 cc_score:0.0 bp_score:0.031631 mf_score:0.0 relationship: child_of NeXO:9871 ! CC: | BP: | MF: [Term] id: NeXO:9739 name: CC: | BP: regulation of growth of unicellular organism as a thread of attached cells | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.64041086377219 density:0.181818181818182 bootstrap:0.299753481 cc_score:0.0 bp_score:0.114463 mf_score:0.0 relationship: child_of NeXO:9898 ! CC: | BP: cellular response to abiotic stimulus | MF: [Term] id: NeXO:9738 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.84744741308022 density:0.124777183600713 bootstrap:0.158635544 cc_score:0.0 bp_score:0.0711998 mf_score:0.0693141 relationship: child_of NeXO:9880 ! CC: | BP: | MF: [Term] id: NeXO:7344 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11841112112327 density:1 bootstrap:0.74360507 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7905 ! CC: | BP: glutathione biosynthetic process | MF:glutathione synthase activity relationship: linked_to NeXO:6519 ! CC: | BP: | MF:proton-dependent oligopeptide secondary active transmembrane transporter activity [Term] id: NeXO:7345 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.80586052104199 density:0.666666666666667 bootstrap:0.717472231 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7689 ! CC: | BP: | MF:sterol transporter activity [Term] id: NeXO:7342 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.53981965148655 density:1 bootstrap:0.84753144 cc_score:0.0 bp_score:0.0133713 mf_score:0.0 relationship: child_of NeXO:8335 ! CC: | BP: | MF: [Term] id: NeXO:8868 name: CC: | BP: ATP transport | MF:ATP transport def: "CC_def: | BP_def: The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:1.32354067842846 density:0.333333333333333 bootstrap:0.354693845 cc_score:0.0 bp_score:0.138173 mf_score:0.133394 relationship: child_of NeXO:9396 ! CC: | BP: | MF: relationship: linked_to NeXO:6949 ! CC: mitochondrial inner membrane protein insertion complex | BP: protein import into mitochondrial inner membrane | MF: relationship: linked_to NeXO:8575 ! CC: | BP: | MF: [Term] id: NeXO:5139 name: CC: | BP: | MF:di-trans,poly-cis-decaprenylcistransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.738473961 cc_score:0.0 bp_score:0.0 mf_score:0.440752 relationship: child_of NeXO:5144 ! CC: | BP: | MF:acylglycerol lipase activity [Term] id: NeXO:7341 name: CC: | BP: | MF:medium-chain fatty acid-CoA ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12." [NeXO-GO:term] namespace: NeXO comment: robustness:1.20372671729658 density:0.2 bootstrap:0.175076102 cc_score:0.0 bp_score:0.0 mf_score:0.186144 relationship: child_of NeXO:7890 ! CC: | BP: long-chain fatty acid transport | MF:fatty acid ligase activity [Term] id: NeXO:5137 name: CC: | BP: kynurenic acid biosynthetic process | MF:kynurenine-oxoglutarate transaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid. | MF_def:Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9218897 cc_score:0.0 bp_score:0.437751 mf_score:0.439776 relationship: child_of NeXO:5393 ! CC: | BP: | MF: [Term] id: NeXO:5135 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91668048 cc_score:0.0 bp_score:0.0 mf_score:0.0711549 relationship: child_of NeXO:5152 ! CC: | BP: | MF: [Term] id: NeXO:8869 name: CC: | BP: inorganic anion transport | MF: def: "CC_def: | BP_def: The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.14253083324757 density:0.0736842105263158 bootstrap:0.266115025 cc_score:0.0372188 bp_score:0.111019 mf_score:0.0 relationship: child_of NeXO:9367 ! CC: | BP: | MF: [Term] id: NeXO:10022 name: CC: cytosolic ribosome | BP: cytoplasmic translation | MF:structural constituent of ribosome def: "CC_def: A ribosome located in the cytosol. | BP_def: The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. | MF_def:The action of a molecule that contributes to the structural integrity of the ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:24.2599440202287 density:0.294331395348837 bootstrap:0.80263975 cc_score:0.509793 bp_score:0.473687 mf_score:0.386814 relationship: child_of NeXO:10023 ! CC: GO:0044391 | BP: ribosome biogenesis | MF: [Term] id: NeXO:10023 name: CC: GO:0044391 | BP: ribosome biogenesis | MF: def: "CC_def: | BP_def: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.4397419821011 density:0.109117451891175 bootstrap:0.68671541 cc_score:0.284409 bp_score:0.283842 mf_score:0.086167 relationship: child_of NeXO:10024 ! CC: ribonucleoprotein complex | BP: ribonucleoprotein complex biogenesis | MF:structural molecule activity [Term] id: NeXO:5131 name: CC: | BP: mitochondrial asparaginyl-tRNA aminoacylation | MF:L-aspartate:2-oxoglutarate aminotransferase activity def: "CC_def: | BP_def: The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.672862295 cc_score:0.0 bp_score:0.44411 mf_score:0.293941 relationship: child_of NeXO:5146 ! CC: | BP: aspartate biosynthetic process | MF:2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [Term] id: NeXO:7349 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68975532299973 density:0.666666666666667 bootstrap:0.260207965 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7514 ! CC: | BP: | MF:NADH pyrophosphatase activity relationship: linked_to NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:7923 ! CC: | BP: | MF: [Term] id: NeXO:7303 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70544072432254 density:0.166666666666667 bootstrap:0.68448275 cc_score:0.0 bp_score:0.019394 mf_score:0.0216684 relationship: child_of NeXO:8526 ! CC: | BP: ribose phosphate biosynthetic process | MF:diphosphotransferase activity [Term] id: NeXO:9855 name: CC: | BP: DNA integrity checkpoint | MF: def: "CC_def: | BP_def: Any cell cycle checkpoint that regulates cell cycle progression in response to changes in DNA structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:21.357155868156 density:0.77124183006536 bootstrap:0.720881893 cc_score:0.0363112 bp_score:0.157476 mf_score:0.0 relationship: child_of NeXO:9951 ! CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding [Term] id: NeXO:5425 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.87516406621508 density:0.333333333333333 bootstrap:0.88238915 cc_score:0.0 bp_score:0.0240947 mf_score:0.0 relationship: child_of NeXO:6188 ! CC: | BP: iron-sulfur cluster assembly | MF: [Term] id: NeXO:7462 name: CC: | BP: mitochondrial aspartyl-tRNA aminoacylation | MF:aspartate-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.82584012661231 density:0.666666666666667 bootstrap:0.727726375 cc_score:0.0 bp_score:0.315533 mf_score:0.23036 relationship: child_of NeXO:8339 ! CC: | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: [Term] id: NeXO:8909 name: CC: mRNA cap methyltransferase complex | BP: mRNA capping | MF:mRNA guanylyltransferase activity def: "CC_def: A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. | BP_def: Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. | MF_def:Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [NeXO-GO:term] namespace: NeXO comment: robustness:2.18261102870607 density:1 bootstrap:0.78935895 cc_score:0.293453 bp_score:0.178793 mf_score:0.447336 relationship: child_of NeXO:9543 ! CC: | BP: | MF:RNA guanylyltransferase activity relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity relationship: linked_to NeXO:5413 ! CC: | BP: | MF: [Term] id: NeXO:8643 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73752661922847 density:0.666666666666667 bootstrap:0.651664683 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9353 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: relationship: linked_to NeXO:9326 ! CC: | BP: cellular amide catabolic process | MF:nucleobase:cation symporter activity [Term] id: NeXO:8120 name: CC: | BP: DNA catabolic process, endonucleolytic | MF:5'-flap endonuclease activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. | MF_def:Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [NeXO-GO:term] namespace: NeXO comment: robustness:1.63960810049363 density:1 bootstrap:0.445453071 cc_score:0.0 bp_score:0.229058 mf_score:0.14884 relationship: child_of NeXO:8556 ! CC: | BP: | MF: relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity [Term] id: NeXO:7093 name: CC: | BP: protein histidine kinase activity | MF:histidine phosphotransfer kinase activity def: "CC_def: | BP_def: Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. | MF_def:Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [NeXO-GO:term] namespace: NeXO comment: robustness:1.95810928198575 density:0.333333333333333 bootstrap:0.776341705 cc_score:0.0 bp_score:0.200562 mf_score:0.268634 relationship: child_of NeXO:8444 ! CC: | BP: two-component signal transduction system (phosphorelay) | MF:two-component signal transduction system (phosphorelay) [Term] id: NeXO:5424 name: CC: | BP: mitochondrial tRNA thio-modification | MF:cysteine desulfurase activity def: "CC_def: | BP_def: The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. | MF_def:Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [NeXO-GO:term] namespace: NeXO comment: robustness:3.16041324995903 density:0.666666666666667 bootstrap:0.91025 cc_score:0.0 bp_score:0.233993 mf_score:0.317082 relationship: child_of NeXO:5425 ! CC: | BP: | MF: [Term] id: NeXO:7009 name: CC: | BP: | MF:COPII adaptor activity def: "CC_def: | BP_def: | MF_def:The binding activity of a molecule that brings together the COPII vesicle proteins and one or more other molecules, permitting them to function in a coordinated way." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.375585915 cc_score:0.0 bp_score:0.0 mf_score:0.25096 relationship: child_of NeXO:7616 ! CC: | BP: | MF: relationship: linked_to NeXO:6781 ! CC: | BP: | MF: [Term] id: NeXO:7008 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.466987621 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7914 ! CC: | BP: | MF: [Term] id: NeXO:9029 name: CC: | BP: | MF:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [NeXO-GO:term] namespace: NeXO comment: robustness:1.50984125516073 density:0.666666666666667 bootstrap:0.207747361 cc_score:0.0 bp_score:0.0 mf_score:0.124132 relationship: child_of NeXO:9296 ! CC: | BP: | MF: [Term] id: NeXO:9028 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.66171565371986 density:0.0222222222222222 bootstrap:0.337973181 cc_score:0.0 bp_score:0.0443535 mf_score:0.0604269 relationship: child_of NeXO:9578 ! CC: | BP: | MF: [Term] id: NeXO:7001 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45229160075925 density:0.0952380952380952 bootstrap:0.31231711 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7379 ! CC: | BP: | MF: [Term] id: NeXO:9024 name: CC: | BP: actin cytoskeleton reorganization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.21009008829837 density:0.333333333333333 bootstrap:0.296493019 cc_score:0.0 bp_score:0.126165 mf_score:0.0 relationship: child_of NeXO:9471 ! CC: | BP: lipid tube assembly | MF: relationship: linked_to NeXO:7581 ! CC: | BP: | MF: [Term] id: NeXO:7003 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.69421107545209 density:0.133333333333333 bootstrap:0.385964274 cc_score:0.0 bp_score:0.0449913 mf_score:0.0605151 relationship: child_of NeXO:7702 ! CC: | BP: | MF: [Term] id: NeXO:7002 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.29609366441491 density:0.166666666666667 bootstrap:0.39533205 cc_score:0.0 bp_score:0.0 mf_score:0.0107933 relationship: child_of NeXO:7537 ! CC: | BP: UDP-galactose transport | MF:UDP-galactose transmembrane transporter activity [Term] id: NeXO:7005 name: CC: | BP: tryptophan transport | MF:L-tryptophan transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:2.53270510330792 density:0.333333333333333 bootstrap:0.68470602 cc_score:0.0 bp_score:0.446654 mf_score:0.428504 relationship: child_of NeXO:7790 ! CC: | BP: aromatic amino acid transport | MF:aromatic amino acid transmembrane transporter activity [Term] id: NeXO:7004 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.53737183498738 density:1 bootstrap:0.69112978 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7474 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:9023 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45787084105096 density:0.0444444444444444 bootstrap:0.405552053 cc_score:0.0 bp_score:0.0642493 mf_score:0.0 relationship: child_of NeXO:9758 ! CC: | BP: cortical actin cytoskeleton organization | MF: [Term] id: NeXO:7006 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.85387538638187 density:1 bootstrap:0.9463494 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7773 ! CC: | BP: cullin deneddylation | MF: [Term] id: NeXO:8567 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.458497356 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9023 ! CC: | BP: | MF: [Term] id: NeXO:5229 name: CC: chloride channel complex | BP: chloride transport | MF:voltage-gated chloride channel activity def: "CC_def: An ion channel complex through which chloride ions pass. | BP_def: The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79907294 cc_score:0.451676 bp_score:0.294134 mf_score:0.446417 relationship: child_of NeXO:5968 ! CC: ion channel complex | BP: | MF: [Term] id: NeXO:5228 name: CC: | BP: mitochondrial RNA 5'-end processing | MF:exoribonuclease II activity def: "CC_def: | BP_def: Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. | MF_def:Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [NeXO-GO:term] namespace: NeXO comment: robustness:2.30492299498677 density:1 bootstrap:0.88030808 cc_score:0.0 bp_score:0.440831 mf_score:0.439818 relationship: child_of NeXO:5824 ! CC: | BP: RNA folding | MF: [Term] id: NeXO:8566 name: CC: mitochondrial inner membrane presequence translocase complex | BP: | MF: def: "CC_def: The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.59179055336148 density:0.904761904761905 bootstrap:0.67520296 cc_score:0.497248 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8795 ! CC: | BP: protein import into mitochondrial matrix | MF:protein channel activity [Term] id: NeXO:5223 name: CC: | BP: base-excision repair, gap-filling | MF: def: "CC_def: | BP_def: Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90603878 cc_score:0.0 bp_score:0.293333 mf_score:0.0 relationship: child_of NeXO:6003 ! CC: | BP: | MF: [Term] id: NeXO:5222 name: CC: | BP: spermine biosynthetic process | MF:adenosylmethionine decarboxylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.36614738125019 density:1 bootstrap:0.92769546 cc_score:0.0 bp_score:0.8905 mf_score:0.439523 relationship: child_of NeXO:5814 ! CC: | BP: spermidine biosynthetic process | MF:spermine synthase activity [Term] id: NeXO:5220 name: CC: | BP: butanediol biosynthetic process | MF:(R,R)-butanediol dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. | MF_def:Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.851164316 cc_score:0.0 bp_score:0.438108 mf_score:0.438098 relationship: child_of NeXO:6861 ! CC: | BP: | MF:diacetyl reductase ((R)-acetoin forming) activity [Term] id: NeXO:5227 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93960383 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5422 ! CC: | BP: | MF:NEDD8 activating enzyme activity [Term] id: NeXO:5226 name: CC: | BP: biotin biosynthetic process | MF:dethiobiotin synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. | MF_def:Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.11767111472664 density:0.666666666666667 bootstrap:0.88579564 cc_score:0.0 bp_score:0.242997 mf_score:0.320217 relationship: child_of NeXO:6049 ! CC: | BP: amide biosynthetic process | MF:cyclo-ligase activity [Term] id: NeXO:5225 name: CC: | BP: | MF:adenosylmethionine-8-amino-7-oxononanoate transaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92162122 cc_score:0.0 bp_score:0.0929843 mf_score:0.439776 relationship: child_of NeXO:5226 ! CC: | BP: biotin biosynthetic process | MF:dethiobiotin synthase activity [Term] id: NeXO:5224 name: CC: | BP: mitochondrial glutamyl-tRNA aminoacylation | MF:adenylosuccinate synthase activity def: "CC_def: | BP_def: The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86729983 cc_score:0.0 bp_score:0.444105 mf_score:0.438032 relationship: child_of NeXO:6379 ! CC: | BP: glutamyl-tRNA aminoacylation | MF: [Term] id: NeXO:8936 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.92473580769212 density:0.0357142857142857 bootstrap:0.312667547 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9328 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:8937 name: CC: | BP: hexose transport | MF:glucose transport def: "CC_def: | BP_def: The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. | MF_def:The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:13.4348928040638 density:0.651515151515151 bootstrap:0.82344308 cc_score:0.0 bp_score:0.344756 mf_score:0.36468 relationship: child_of NeXO:9570 ! CC: | BP: carbohydrate transport | MF:fructose transport [Term] id: NeXO:8930 name: CC: | BP: establishment of mitotic sister chromatid cohesion | MF: def: "CC_def: | BP_def: The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.0464280459275 density:1 bootstrap:0.796345954 cc_score:0.0 bp_score:0.391331 mf_score:0.0 relationship: child_of NeXO:9625 ! CC: | BP: maintenance of meiotic sister chromatid cohesion | MF: relationship: linked_to NeXO:9727 ! CC: | BP: mitotic cell cycle G2/M transition decatenation checkpoint | MF: [Term] id: NeXO:8931 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15406295128823 density:0.833333333333333 bootstrap:0.350462964 cc_score:0.0 bp_score:0.0203688 mf_score:0.0 relationship: child_of NeXO:9661 ! CC: nuclear envelope lumen | BP: positive regulation of gluconeogenesis | MF: [Term] id: NeXO:8932 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.67578937673262 density:0.0574712643678161 bootstrap:0.230367925 cc_score:0.0 bp_score:0.0606148 mf_score:0.0 relationship: child_of NeXO:9673 ! CC: | BP: | MF: [Term] id: NeXO:8938 name: CC: proton-transporting two-sector ATPase complex | BP: regulation of intracellular pH | MF:ATPase activity, coupled to transmembrane movement of ions def: "CC_def: A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. | BP_def: Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. | MF_def:Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:16.9103423600752 density:0.422924901185771 bootstrap:0.59960275 cc_score:0.276891 bp_score:0.410855 mf_score:0.19829 relationship: child_of NeXO:9609 ! CC: mitochondrial ribosome | BP: regulation of pH | MF: [Term] id: NeXO:8939 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.89731335965754 density:0.266666666666667 bootstrap:0.313738771 cc_score:0.0 bp_score:0.039358 mf_score:0.0 relationship: child_of NeXO:9488 ! CC: | BP: | MF: [Term] id: NeXO:7306 name: CC: Ku70:Ku80 complex | BP: | MF: def: "CC_def: Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26246994688743 density:1 bootstrap:0.84817894 cc_score:0.87516 bp_score:0.0721016 mf_score:0.0936613 relationship: child_of NeXO:8815 ! CC: DNA-dependent protein kinase-DNA ligase 4 complex | BP: negative regulation of telomerase activity | MF:telomerase activity relationship: linked_to NeXO:9094 ! CC: nuclear telomeric heterochromatin | BP: loss of chromatin silencing involved in replicative cell aging | MF:structural constituent of chromatin [Term] id: NeXO:7091 name: CC: | BP: | MF:aralkylamine N-acetyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.519446341 cc_score:0.0 bp_score:0.0 mf_score:0.438531 relationship: child_of NeXO:8540 ! CC: | BP: | MF: relationship: linked_to NeXO:7092 ! CC: | BP: regulation of MAP kinase activity | MF: [Term] id: NeXO:5884 name: CC: | BP: alkaline phosphatase activity | MF:4-nitrophenylphosphatase activity def: "CC_def: | BP_def: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. | MF_def:Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84275112 cc_score:0.0 bp_score:0.291667 mf_score:0.437952 relationship: child_of NeXO:6208 ! CC: | BP: polyol biosynthetic process | MF:alkaline phosphatase activity [Term] id: NeXO:6891 name: CC: | BP: cellular response to calcium ion | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.681126975 cc_score:0.0 bp_score:0.442171 mf_score:0.0 relationship: child_of NeXO:7872 ! CC: | BP: positive regulation of sodium ion transport | MF: relationship: linked_to NeXO:9756 ! CC: | BP: histone dephosphorylation | MF: [Term] id: NeXO:7174 name: CC: | BP: lysine transport | MF:cadmium-exporting ATPase activity def: "CC_def: | BP_def: The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64931041 cc_score:0.0 bp_score:0.442295 mf_score:0.446654 relationship: child_of NeXO:7743 ! CC: | BP: arginine transport | MF:lysine transport relationship: linked_to NeXO:7349 ! CC: | BP: | MF: [Term] id: NeXO:7177 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.26465955866094 density:0.3 bootstrap:0.799537044 cc_score:0.0 bp_score:0.0 mf_score:0.0248526 relationship: child_of NeXO:8946 ! CC: | BP: snRNA pseudouridine synthesis | MF: [Term] id: NeXO:6892 name: CC: | BP: spore germination | MF: def: "CC_def: | BP_def: The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88250818 cc_score:0.0 bp_score:0.219011 mf_score:0.0 relationship: child_of NeXO:8008 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7171 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82292105589028 density:1 bootstrap:0.550627084 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7895 ! CC: | BP: | MF: relationship: linked_to NeXO:7801 ! CC: | BP: | MF: relationship: linked_to NeXO:6869 ! CC: | BP: | MF: relationship: linked_to NeXO:7893 ! CC: | BP: heme O biosynthetic process | MF:protoheme IX farnesyltransferase activity [Term] id: NeXO:7170 name: CC: | BP: GO:0061393 | MF:mitogen-activated protein kinase binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a mitogen-activated protein kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73103124 cc_score:0.0 bp_score:0.314348 mf_score:0.231165 relationship: child_of NeXO:8497 ! CC: | BP: gene silencing by RNA | MF:histone deacetylase activity (H3-K16 specific) relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: [Term] id: NeXO:6897 name: CC: Vps55/Vps68 complex | BP: | MF: def: "CC_def: A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.634833097 cc_score:0.229872 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8022 ! CC: | BP: | MF: [Term] id: NeXO:6896 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77400679 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6897 ! CC: Vps55/Vps68 complex | BP: | MF: [Term] id: NeXO:8292 name: CC: zeta DNA polymerase complex | BP: nucleotide-excision repair, DNA incision, 5'-to lesion | MF: def: "CC_def: A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. | BP_def: The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.519579781 cc_score:0.294406 bp_score:0.299293 mf_score:0.0 relationship: child_of NeXO:9108 ! CC: nucleotide-excision repair factor 1 complex | BP: gene conversion at mating-type locus, DNA repair synthesis | MF:nucleoside binding relationship: linked_to NeXO:9180 ! CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: relationship: linked_to NeXO:7428 ! CC: | BP: error-prone translesion synthesis | MF: [Term] id: NeXO:7178 name: CC: | BP: | MF:6-phosphogluconolactonase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.64257234765049 density:1 bootstrap:0.447065196 cc_score:0.0 bp_score:0.0 mf_score:0.176357 relationship: child_of NeXO:7521 ! CC: | BP: | MF: [Term] id: NeXO:5357 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89343557 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5432 ! CC: ASTRA complex | BP: | MF: [Term] id: NeXO:5356 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2264537178878 density:1 bootstrap:0.821389582 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5434 ! CC: | BP: | MF: [Term] id: NeXO:5355 name: CC: glyoxysome | BP: | MF:pyruvate carboxylase activity def: "CC_def: A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds. | BP_def: | MF_def:Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83112361 cc_score:0.292389 bp_score:0.0 mf_score:0.299506 relationship: child_of NeXO:6601 ! CC: | BP: | MF:malate synthase activity [Term] id: NeXO:5354 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.813367269 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5785 ! CC: condensed chromosome inner kinetochore | BP: | MF: [Term] id: NeXO:5353 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87782963 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5464 ! CC: | BP: | MF: [Term] id: NeXO:5352 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.24869664723665 density:1 bootstrap:0.83788341 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5454 ! CC: | BP: | MF: [Term] id: NeXO:5351 name: CC: | BP: | MF:NADPH-hemoprotein reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.865372668 cc_score:0.0 bp_score:0.0694752 mf_score:0.445412 relationship: child_of NeXO:6023 ! CC: | BP: | MF: [Term] id: NeXO:9960 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.21193701734597 density:0.0245728643216080 bootstrap:0.119587488 cc_score:0.053725 bp_score:0.0625403 mf_score:0.0456319 relationship: child_of NeXO:9998 ! CC: mitochondrial part | BP: localization | MF:transporter activity [Term] id: NeXO:5359 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.36600087227251 density:1 bootstrap:0.92758058 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6526 ! CC: | BP: positive regulation of mitochondrial translation | MF:translation regulator activity [Term] id: NeXO:8569 name: CC: | BP: cytosol to ER transport | MF: def: "CC_def: | BP_def: The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.54776885526457 density:1 bootstrap:0.396948398 cc_score:0.0 bp_score:0.437754 mf_score:0.0 relationship: child_of NeXO:9029 ! CC: | BP: | MF:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor relationship: linked_to NeXO:8475 ! CC: oligosaccharyltransferase complex | BP: protein N-linked glycosylation via asparagine | MF:dolichyl-diphosphooligosaccharide-protein glycotransferase activity [Term] id: NeXO:5289 name: CC: | BP: telomere maintenance via telomere shortening | MF: def: "CC_def: | BP_def: Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88604633 cc_score:0.0 bp_score:0.438298 mf_score:0.0 relationship: child_of NeXO:5290 ! CC: | BP: | MF: [Term] id: NeXO:7573 name: CC: Ssh1 translocon complex | BP: | MF: def: "CC_def: A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.410293708 cc_score:0.187315 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8230 ! CC: | BP: dTDP biosynthetic process | MF:uridylate kinase activity [Term] id: NeXO:8798 name: CC: | BP: positive regulation of macroautophagy | MF: def: "CC_def: | BP_def: Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11623703945673 density:0.666666666666667 bootstrap:0.40813286 cc_score:0.0 bp_score:0.151628 mf_score:0.0417513 relationship: child_of NeXO:9311 ! CC: | BP: | MF: relationship: linked_to NeXO:6807 ! CC: | BP: | MF: [Term] id: NeXO:8799 name: CC: | BP: terpenoid biosynthetic process | MF:farnesyltranstransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. | MF_def:Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.14196135242631 density:0.333333333333333 bootstrap:0.264047389 cc_score:0.0 bp_score:0.165075 mf_score:0.16147 relationship: child_of NeXO:9226 ! CC: | BP: | MF: [Term] id: NeXO:8248 name: CC: | BP: negative regulation of mitotic recombination | MF:NAD+ binding def: "CC_def: | BP_def: Any process that inhibits or decreases the rate of DNA recombination during mitosis. | MF_def:Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [NeXO-GO:term] namespace: NeXO comment: robustness:3.9853582035644 density:0.5 bootstrap:0.644188597 cc_score:0.0 bp_score:0.292789 mf_score:0.351963 relationship: child_of NeXO:8706 ! CC: | BP: regulation of mitotic recombination | MF:NAD-dependent histone deacetylase activity [Term] id: NeXO:7572 name: CC: chromatin accessibility complex | BP: negative regulation of transcription from RNA polymerase II promoter by pheromones | MF: def: "CC_def: A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. | BP_def: Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.96239659578965 density:1 bootstrap:0.638109794 cc_score:0.438569 bp_score:0.197681 mf_score:0.0 relationship: child_of NeXO:9095 ! CC: | BP: regulation of transcription from RNA polymerase II promoter by pheromones | MF: relationship: linked_to NeXO:6013 ! CC: | BP: | MF: [Term] id: NeXO:8242 name: CC: | BP: histone peptidyl-prolyl isomerization | MF:FK506 binding def: "CC_def: | BP_def: The modification of a histone by cis-trans isomerization of a proline residue. | MF_def:Interacting selectively and non-covalently with the immunosuppressant FK506." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.470816085 cc_score:0.0 bp_score:0.293539 mf_score:0.181485 relationship: child_of NeXO:8683 ! CC: | BP: formation of translation preinitiation complex | MF: [Term] id: NeXO:8243 name: CC: | BP: | MF:CTD phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.633280002 cc_score:0.0 bp_score:0.0 mf_score:0.439146 relationship: child_of NeXO:8552 ! CC: | BP: | MF: relationship: linked_to NeXO:8557 ! CC: | BP: | MF:transcription from RNA polymerase III promoter relationship: linked_to NeXO:8370 ! CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding relationship: linked_to NeXO:9282 ! CC: Set3 complex | BP: positive regulation of stress-activated MAPK cascade | MF:NAD-independent histone deacetylase activity [Term] id: NeXO:8240 name: CC: | BP: threonyl-tRNA aminoacylation | MF:threonine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.41229782 cc_score:0.0 bp_score:0.282849 mf_score:0.292781 relationship: child_of NeXO:8781 ! CC: | BP: | MF: [Term] id: NeXO:8241 name: CC: cytoplasmic exosome (RNase complex) | BP: nonfunctional rRNA decay | MF: def: "CC_def: Complex of 3'-5' exoribonucleases found in the cytoplasm. | BP_def: An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.47531447824684 density:1 bootstrap:0.56674809 cc_score:0.51379 bp_score:0.36411 mf_score:0.0 relationship: child_of NeXO:9449 ! CC: exosome (RNase complex) | BP: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:8246 name: CC: Noc2p-Noc3p complex | BP: | MF: def: "CC_def: A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09482465389491 density:1 bootstrap:0.7271386 cc_score:0.293609 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9083 ! CC: | BP: | MF: relationship: linked_to NeXO:9084 ! CC: | BP: regulation of histone H3-K36 methylation | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: [Term] id: NeXO:8795 name: CC: | BP: protein import into mitochondrial matrix | MF:protein channel activity def: "CC_def: | BP_def: The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. | MF_def:Catalysis of energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [NeXO-GO:term] namespace: NeXO comment: robustness:9.51833002893022 density:0.53030303030303 bootstrap:0.53923353 cc_score:0.0 bp_score:0.405 mf_score:0.327235 relationship: child_of NeXO:9721 ! CC: | BP: intracellular protein transmembrane transport | MF:protein transmembrane transporter activity [Term] id: NeXO:9322 name: CC: | BP: cell wall chitin catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.21651288203883 density:0.333333333333333 bootstrap:0.299648763 cc_score:0.0 bp_score:0.314961 mf_score:0.0 relationship: child_of NeXO:9619 ! CC: | BP: | MF: relationship: linked_to NeXO:6441 ! CC: ESCRT II complex | BP: negative regulation of transcription from RNA polymerase II promoter by glucose | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: relationship: linked_to NeXO:8165 ! CC: ESCRT III complex | BP: intralumenal vesicle formation | MF: [Term] id: NeXO:8797 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.77721751080578 density:0.0448717948717949 bootstrap:0.195945315 cc_score:0.0 bp_score:0.0889182 mf_score:0.0 relationship: child_of NeXO:9620 ! CC: | BP: | MF: [Term] id: NeXO:5288 name: CC: | BP: intracellular sequestering of iron ion | MF: def: "CC_def: | BP_def: The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85594391 cc_score:0.0 bp_score:0.219534 mf_score:0.0 relationship: child_of NeXO:6027 ! CC: | BP: | MF: [Term] id: NeXO:5460 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79991269 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7250 ! CC: | BP: | MF: [Term] id: NeXO:5463 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80425842 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6834 ! CC: | BP: | MF: [Term] id: NeXO:7579 name: CC: | BP: pyrimidine base biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.86890464026555 density:0.236363636363636 bootstrap:0.4689868 cc_score:0.0 bp_score:0.248206 mf_score:0.0759244 relationship: child_of NeXO:7937 ! CC: | BP: pyrimidine base metabolic process | MF: [Term] id: NeXO:5462 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77080724 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6352 ! CC: | BP: | MF:phosphodiesterase I activity [Term] id: NeXO:8648 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.330986978 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9033 ! CC: | BP: | MF: relationship: linked_to NeXO:8350 ! CC: | BP: | MF: [Term] id: NeXO:5723 name: CC: | BP: | MF:chitin synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.10160138439545 density:0.666666666666667 bootstrap:0.87668768 cc_score:0.0 bp_score:0.0625762 mf_score:0.430537 relationship: child_of NeXO:6396 ! CC: | BP: dolichol-linked oligosaccharide biosynthetic process | MF: [Term] id: NeXO:8646 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.97592075218109 density:0.5 bootstrap:0.35918735 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8759 ! CC: | BP: | MF: relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:5465 name: CC: | BP: regulation of termination of mating projection growth | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81692268 cc_score:0.0 bp_score:0.154192 mf_score:0.0 relationship: child_of NeXO:7401 ! CC: | BP: | MF: [Term] id: NeXO:8644 name: CC: | BP: | MF:cysteine-type endopeptidase inhibitor activity def: "CC_def: | BP_def: | MF_def:Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [NeXO-GO:term] namespace: NeXO comment: robustness:2.51050532574765 density:0.666666666666667 bootstrap:0.57437461 cc_score:0.0 bp_score:0.0273248 mf_score:0.272384 relationship: child_of NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity [Term] id: NeXO:8645 name: CC: | BP: regulation of stress-activated MAPK cascade | MF:Hsp70 protein binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. | MF_def:Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [NeXO-GO:term] namespace: NeXO comment: robustness:2.06430784491161 density:0.333333333333333 bootstrap:0.454866362 cc_score:0.0 bp_score:0.149851 mf_score:0.387307 relationship: child_of NeXO:9332 ! CC: | BP: | MF:ATPase inhibitor activity [Term] id: NeXO:8642 name: CC: eisosome | BP: | MF: def: "CC_def: Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.6564296895585 density:0.571428571428571 bootstrap:0.740304055 cc_score:0.458272 bp_score:0.0841508 mf_score:0.0 relationship: child_of NeXO:8939 ! CC: | BP: | MF: [Term] id: NeXO:5720 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.43391397 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7162 ! CC: | BP: | MF: [Term] id: NeXO:8640 name: CC: trans-Golgi network transport vesicle | BP: cell wall polysaccharide biosynthetic process | MF: def: "CC_def: A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. | BP_def: The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.44146019105737 density:0.178571428571429 bootstrap:0.31831795 cc_score:0.12302 bp_score:0.126303 mf_score:0.0 relationship: child_of NeXO:9160 ! CC: | BP: | MF: [Term] id: NeXO:8641 name: CC: | BP: regulation of mRNA export from nucleus in response to heat stress | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26873414650471 density:0.333333333333333 bootstrap:0.549417022 cc_score:0.0 bp_score:0.253694 mf_score:0.0 relationship: child_of NeXO:9059 ! CC: | BP: | MF: relationship: linked_to NeXO:9092 ! CC: NDC1 complex | BP: mRNA export from nucleus in response to heat stress | MF: [Term] id: NeXO:8426 name: CC: | BP: COPII vesicle coating | MF:Sar guanyl-nucleotide exchange factor activity def: "CC_def: | BP_def: The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. | MF_def:Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.340364925 cc_score:0.0 bp_score:0.36292 mf_score:0.43816 relationship: child_of NeXO:9492 ! CC: ER to Golgi transport vesicle membrane | BP: COPII-coated vesicle budding | MF: relationship: linked_to NeXO:8298 ! CC: COPII vesicle coat | BP: regulation of COPII vesicle coating | MF: [Term] id: NeXO:8427 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62577387400158 density:1 bootstrap:0.437967745 cc_score:0.0 bp_score:0.0502694 mf_score:0.0 relationship: child_of NeXO:8877 ! CC: | BP: | MF: [Term] id: NeXO:8424 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45873917783592 density:1 bootstrap:0.352595805 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8827 ! CC: | BP: | MF: relationship: linked_to NeXO:9211 ! CC: proteasome regulatory particle, base subcomplex | BP: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:7942 ! CC: | BP: | MF: relationship: linked_to NeXO:8137 ! CC: | BP: uracil metabolic process | MF: [Term] id: NeXO:8425 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35896000621303 density:0.075 bootstrap:0.226418084 cc_score:0.0 bp_score:0.0 mf_score:0.040075 relationship: child_of NeXO:9425 ! CC: | BP: | MF: [Term] id: NeXO:8422 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.71109532503739 density:0.2 bootstrap:0.353768759 cc_score:0.0 bp_score:0.0743818 mf_score:0.0 relationship: child_of NeXO:9457 ! CC: | BP: | MF: [Term] id: NeXO:8423 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.87679600835691 density:0.075 bootstrap:0.336734869 cc_score:0.0 bp_score:0.0135689 mf_score:0.0 relationship: child_of NeXO:9274 ! CC: | BP: | MF: [Term] id: NeXO:8420 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.670115216463 density:0.888888888888889 bootstrap:0.70587477 cc_score:0.0 bp_score:0.0104652 mf_score:0.0884605 relationship: child_of NeXO:8901 ! CC: | BP: ergosterol biosynthetic process | MF:monooxygenase activity [Term] id: NeXO:8421 name: CC: cellular bud neck split septin rings | BP: regulation of nuclear-transcribed mRNA poly(A) tail shortening | MF: def: "CC_def: Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated. | BP_def: Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.30127766 cc_score:0.293004 bp_score:0.147426 mf_score:0.0 relationship: child_of NeXO:9203 ! CC: | BP: | MF:inositol hexakisphosphate 4-kinase activity [Term] id: NeXO:6411 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64548036893806 density:0.666666666666667 bootstrap:0.637796345 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6412 ! CC: | BP: | MF: [Term] id: NeXO:8428 name: CC: | BP: regulation of cell growth | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate, extent or direction of cell growth. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.8636999781227 density:0.163636363636364 bootstrap:0.468814581 cc_score:0.0 bp_score:0.184476 mf_score:0.0 relationship: child_of NeXO:9358 ! CC: | BP: regulation of growth | MF: [Term] id: NeXO:6410 name: CC: chitosan layer of spore wall | BP: chitin catabolic process | MF:chitin deacetylase activity def: "CC_def: The second outermost layer of the spore wall, as described in Saccharomyces. | BP_def: The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. | MF_def:Catalysis of the reaction: chitin + H2O = chitosan + acetate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.73682308566395 density:0.666666666666667 bootstrap:0.682600165 cc_score:0.576596 bp_score:0.284079 mf_score:0.569896 relationship: child_of NeXO:6687 ! CC: cell wall part | BP: | MF: [Term] id: NeXO:5740 name: CC: | BP: donor selection | MF: def: "CC_def: | BP_def: The process that determines which donor locus a cell uses, in preference to another, in mating type switching. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.712084287 cc_score:0.0 bp_score:0.146671 mf_score:0.0 relationship: child_of NeXO:6080 ! CC: | BP: | MF: relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: [Term] id: NeXO:5741 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.53364450748421 density:0.5 bootstrap:0.82612066 cc_score:0.0 bp_score:0.0141911 mf_score:0.0 relationship: child_of NeXO:6398 ! CC: | BP: vesicle fusion with vacuole | MF: [Term] id: NeXO:5743 name: CC: | BP: selenocysteine metabolic process | MF:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins. | MF_def:Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.42253664 cc_score:0.0 bp_score:0.206289 mf_score:0.212341 relationship: child_of NeXO:6176 ! CC: | BP: | MF:histidinol dehydrogenase activity [Term] id: NeXO:5744 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.312002459 cc_score:0.0 bp_score:0.0 mf_score:0.0413523 relationship: child_of NeXO:6435 ! CC: | BP: | MF:formate-tetrahydrofolate ligase activity [Term] id: NeXO:5724 name: CC: | BP: triglyceride biosynthetic process | MF:phospholipid:diacylglycerol acyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. | MF_def:Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:1.87485563221238 density:0.333333333333333 bootstrap:0.711729109 cc_score:0.0 bp_score:0.516537 mf_score:0.269348 relationship: child_of NeXO:6175 ! CC: | BP: triglyceride metabolic process | MF:ergosterol O-acyltransferase activity [Term] id: NeXO:5746 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.74513070597154 density:0.333333333333333 bootstrap:0.80437942 cc_score:0.0 bp_score:0.0991979 mf_score:0.0 relationship: child_of NeXO:6384 ! CC: | BP: | MF:beta-glucosidase activity [Term] id: NeXO:5747 name: CC: | BP: fatty acid elongation, unsaturated fatty acid | MF:sphingosine hydroxylase activity def: "CC_def: | BP_def: Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. | MF_def:Catalysis of the hydroxylation of sphingolipid long chain bases." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.57715747 cc_score:0.0 bp_score:0.463782 mf_score:0.437653 relationship: child_of NeXO:6698 ! CC: | BP: | MF: [Term] id: NeXO:5749 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90351843 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5750 ! CC: | BP: copper ion export | MF:copper-exporting ATPase activity [Term] id: NeXO:9320 name: CC: | BP: regulation of nucleosome density | MF: def: "CC_def: | BP_def: Any process that modulates the number of nucleosomes in a given region of a chromosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.75198358346079 density:0.0666666666666667 bootstrap:0.169118736 cc_score:0.0 bp_score:0.143506 mf_score:0.0 relationship: child_of NeXO:9969 ! CC: | BP: | MF: [Term] id: NeXO:6412 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30226027065536 density:0.2 bootstrap:0.64044215 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6736 ! CC: | BP: | MF: [Term] id: NeXO:7478 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.14492512071805 density:0.2 bootstrap:0.82377459 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7954 ! CC: | BP: | MF: [Term] id: NeXO:9838 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.9023642674374 density:0.283333333333333 bootstrap:0.255412542 cc_score:0.0 bp_score:0.0281032 mf_score:0.0 relationship: child_of NeXO:9963 ! CC: Golgi membrane | BP: | MF: [Term] id: NeXO:6478 name: CC: | BP: positive regulation of mRNA processing | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of mRNA processing. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.03044628742497 density:0.3 bootstrap:0.68893139 cc_score:0.0 bp_score:0.118796 mf_score:0.0 relationship: child_of NeXO:7585 ! CC: | BP: | MF: [Term] id: NeXO:5583 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90721454 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5584 ! CC: | BP: NAD biosynthetic process | MF:nicotinamide-nucleotide adenylyltransferase activity [Term] id: NeXO:5580 name: CC: | BP: adenine salvage | MF:phosphoacetylglucosamine mutase activity def: "CC_def: | BP_def: Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. | MF_def:Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49876374 cc_score:0.0 bp_score:0.298876 mf_score:0.441942 relationship: child_of NeXO:5651 ! CC: | BP: UDP-N-acetylglucosamine biosynthetic process | MF:phosphoribosyl-AMP cyclohydrolase activity [Term] id: NeXO:7598 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.51726961 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7947 ! CC: CAF-1 complex | BP: | MF: [Term] id: NeXO:7597 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83224767 cc_score:0.0 bp_score:0.0894507 mf_score:0.0 relationship: child_of NeXO:8643 ! CC: | BP: | MF: [Term] id: NeXO:6472 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67772728 cc_score:0.0 bp_score:0.0750625 mf_score:0.0 relationship: child_of NeXO:7479 ! CC: elongin complex | BP: | MF: [Term] id: NeXO:7595 name: CC: | BP: contractile ring contraction involved in cell cycle cytokinesis | MF:myosin II binding def: "CC_def: | BP_def: The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle. | MF_def:Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.721781078 cc_score:0.0 bp_score:0.175472 mf_score:0.301238 relationship: child_of NeXO:7596 ! CC: | BP: | MF:S-methyl-5-thioribose-1-phosphate isomerase activity [Term] id: NeXO:7594 name: CC: | BP: | MF:glycoprotein binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.332316345 cc_score:0.0 bp_score:0.0 mf_score:0.291787 relationship: child_of NeXO:8943 ! CC: integral to Golgi membrane | BP: | MF: [Term] id: NeXO:7593 name: CC: | BP: pyruvate metabolic process | MF:pyruvate kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. | MF_def:Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.54252681019355 density:0.333333333333333 bootstrap:0.481775274 cc_score:0.0 bp_score:0.132453 mf_score:0.566612 relationship: child_of NeXO:8004 ! CC: | BP: | MF:potassium ion binding [Term] id: NeXO:6476 name: CC: | BP: proline transport | MF:glutathione peroxidase activity def: "CC_def: | BP_def: The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:3.30188868467774 density:0.190476190476190 bootstrap:0.7044852 cc_score:0.0 bp_score:0.103048 mf_score:0.13401 relationship: child_of NeXO:8040 ! CC: | BP: polyol metabolic process | MF: [Term] id: NeXO:9834 name: CC: U2-type precatalytic spliceosome | BP: | MF: def: "CC_def: A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.4862158542456 density:0.272604588394062 bootstrap:0.28618771 cc_score:0.287029 bp_score:0.0842966 mf_score:0.0 relationship: child_of NeXO:9984 ! CC: catalytic step 1 spliceosome | BP: nuclear mRNA splicing, via spliceosome | MF: [Term] id: NeXO:7590 name: CC: | BP: | MF:IMP cyclohydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.29678192 cc_score:0.0 bp_score:0.017466 mf_score:0.297631 relationship: child_of NeXO:8015 ! CC: | BP: | MF:phosphoribosylaminoimidazolecarboxamide formyltransferase activity relationship: linked_to NeXO:8956 ! CC: | BP: termination of RNA polymerase II transcription, exosome-dependent | MF: [Term] id: NeXO:8491 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.59127037619039 density:0.305555555555556 bootstrap:0.676262271 cc_score:0.0 bp_score:0.0796227 mf_score:0.0 relationship: child_of NeXO:9167 ! CC: | BP: | MF: [Term] id: NeXO:9537 name: CC: | BP: tRNA thio-modification | MF: def: "CC_def: | BP_def: The addition a sulfur atom to a nucleotide in a tRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.9812244795554 density:0.276923076923077 bootstrap:0.33959567 cc_score:0.0 bp_score:0.144979 mf_score:0.0 relationship: child_of NeXO:9747 ! CC: | BP: energy reserve metabolic process | MF:phosphatase regulator activity [Term] id: NeXO:7759 name: CC: | BP: positive regulation of autophagy | MF:phosphatidylinositol 3-kinase activity def: "CC_def: | BP_def: Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. | MF_def:Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.689972205 cc_score:0.0 bp_score:0.169005 mf_score:0.160773 relationship: child_of NeXO:8009 ! CC: pre-autophagosomal structure membrane | BP: protein homooligomerization | MF: relationship: linked_to NeXO:7658 ! CC: | BP: C-terminal protein lipidation | MF:APG12 activating enzyme activity [Term] id: NeXO:6844 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.91125793660973 density:0.120879120879121 bootstrap:0.436156154 cc_score:0.0 bp_score:0.026168 mf_score:0.0665784 relationship: child_of NeXO:7319 ! CC: | BP: | MF: [Term] id: NeXO:7757 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.391447605 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8363 ! CC: | BP: | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding [Term] id: NeXO:7756 name: CC: | BP: deadenylation-independent decapping of nuclear-transcribed mRNA | MF:tubulin-tyrosine ligase activity def: "CC_def: | BP_def: Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. | MF_def:Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.64567682881915 density:1 bootstrap:0.44875671 cc_score:0.0 bp_score:0.302612 mf_score:0.438086 relationship: child_of NeXO:8351 ! CC: | BP: | MF:stretch-activated, cation-selective, calcium channel activity relationship: linked_to NeXO:9450 ! CC: | BP: deadenylation-dependent decapping of nuclear-transcribed mRNA | MF:m7G(5')pppN diphosphatase activity relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity [Term] id: NeXO:7751 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.21046312385668 density:0.142857142857143 bootstrap:0.722834693 cc_score:0.0 bp_score:0.0726975 mf_score:0.0883804 relationship: child_of NeXO:8973 ! CC: | BP: | MF:drug transmembrane transport [Term] id: NeXO:7750 name: CC: | BP: response to cadmium ion | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.6402115723343 density:1 bootstrap:0.445781037 cc_score:0.0 bp_score:0.151243 mf_score:0.0 relationship: child_of NeXO:8178 ! CC: | BP: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) | MF:phosphoadenylyl-sulfate reductase (thioredoxin) activity relationship: linked_to NeXO:6992 ! CC: | BP: regulation of sulfur metabolic process | MF: [Term] id: NeXO:7753 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.432110406 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8269 ! CC: | BP: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF: [Term] id: NeXO:9245 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56907676 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9621 ! CC: | BP: regulation of nuclear mRNA splicing, via spliceosome | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: [Term] id: NeXO:6511 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85527888 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7203 ! CC: exomer complex | BP: cell wall chitin biosynthetic process | MF: [Term] id: NeXO:8332 name: CC: ERMES complex | BP: protein import into mitochondrial outer membrane | MF: def: "CC_def: A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth. | BP_def: The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.54894018561876 density:0.227272727272727 bootstrap:0.536238927 cc_score:0.240199 bp_score:0.244276 mf_score:0.0 relationship: child_of NeXO:8469 ! CC: organelle membrane contact site | BP: | MF: [Term] id: NeXO:8333 name: CC: | BP: | MF:rRNA (uridine-2'-O-)-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.485147894 cc_score:0.0 bp_score:0.0876366 mf_score:0.230195 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: [Term] id: NeXO:8330 name: CC: | BP: nuclear pore complex assembly | MF:structural constituent of nuclear pore def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. | MF_def:The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58046088202568 density:1 bootstrap:0.413894208 cc_score:0.0 bp_score:0.35342 mf_score:0.250524 relationship: child_of NeXO:8783 ! CC: | BP: snRNP protein import into nucleus | MF: [Term] id: NeXO:8331 name: CC: | BP: mitochondrion morphogenesis | MF: def: "CC_def: | BP_def: The process in which the anatomical structures of a mitochondrion are generated and organized. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.519961951 cc_score:0.0 bp_score:0.292321 mf_score:0.0 relationship: child_of NeXO:9044 ! CC: | BP: | MF: relationship: linked_to NeXO:7046 ! CC: m-AAA complex | BP: | MF: relationship: linked_to NeXO:9102 ! CC: | BP: protein unfolding | MF: [Term] id: NeXO:9247 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.37247703112024 density:0.0833333333333333 bootstrap:0.20274734 cc_score:0.0 bp_score:0.0359942 mf_score:0.0 relationship: child_of NeXO:9690 ! CC: | BP: | MF: [Term] id: NeXO:8334 name: CC: | BP: positive regulation of transcription involved in G1/S phase of mitotic cell cycle | MF:DNA binding transcription antitermination factor activity def: "CC_def: | BP_def: Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle. | MF_def:Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.17645331656016 density:1 bootstrap:0.78491126 cc_score:0.0 bp_score:0.439574 mf_score:0.442678 relationship: child_of NeXO:9320 ! CC: | BP: regulation of nucleosome density | MF: relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:9301 ! CC: SWI/SNF complex | BP: nucleosome mobilization | MF:positive regulation of transcription, DNA-dependent [Term] id: NeXO:6719 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.65111453632017 density:0.666666666666667 bootstrap:0.64051591 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6845 ! CC: | BP: | MF: [Term] id: NeXO:6716 name: CC: | BP: | MF:nucleoside-diphosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.504783979 cc_score:0.0 bp_score:0.0 mf_score:0.282467 relationship: child_of NeXO:6717 ! CC: | BP: | MF: [Term] id: NeXO:6717 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.74196895591046 density:0.166666666666667 bootstrap:0.71411815 cc_score:0.0 bp_score:0.0238271 mf_score:0.0 relationship: child_of NeXO:8030 ! CC: | BP: | MF: [Term] id: NeXO:8338 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53995569202073 density:0.138888888888889 bootstrap:0.370827356 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9337 ! CC: | BP: cysteine metabolic process | MF:methionine biosynthetic process [Term] id: NeXO:8339 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.25635409934705 density:0.428571428571429 bootstrap:0.328037552 cc_score:0.0 bp_score:0.0261868 mf_score:0.0 relationship: child_of NeXO:9452 ! CC: | BP: purine ribonucleoside triphosphate biosynthetic process | MF:hydrogen ion transmembrane transporter activity [Term] id: NeXO:6712 name: CC: | BP: | MF:CoA hydrolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [NeXO-GO:term] namespace: NeXO comment: robustness:3.9835738819567 density:0.7 bootstrap:0.423569636 cc_score:0.0 bp_score:0.0 mf_score:0.12116 relationship: child_of NeXO:7311 ! CC: | BP: | MF: [Term] id: NeXO:6713 name: CC: | BP: cAMP catabolic process | MF:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.504870996 cc_score:0.0 bp_score:0.43932 mf_score:0.439149 relationship: child_of NeXO:7451 ! CC: | BP: | MF:3',5'-cyclic-AMP phosphodiesterase activity [Term] id: NeXO:6710 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.5231043319918 density:0.666666666666667 bootstrap:0.58015409 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6779 ! CC: | BP: | MF: [Term] id: NeXO:6711 name: CC: | BP: | MF:C-5 sterol desaturase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.36749071718433 density:1 bootstrap:0.62634122 cc_score:0.0 bp_score:0.0 mf_score:0.296822 relationship: child_of NeXO:7098 ! CC: | BP: | MF:delta14-sterol reductase activity relationship: linked_to NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity [Term] id: NeXO:9906 name: CC: microtubule associated complex | BP: cellular component movement | MF: def: "CC_def: Any multimeric complex connected to a microtubule. | BP_def: The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.73395395371 density:0.297348484848485 bootstrap:0.299058897 cc_score:0.192643 bp_score:0.163519 mf_score:0.0 relationship: child_of NeXO:9980 ! CC: microtubule cytoskeleton | BP: microtubule-based process | MF: [Term] id: NeXO:9907 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.43129558088936 density:0.0286298568507157 bootstrap:0.118065688 cc_score:0.0227237 bp_score:0.0586568 mf_score:0.0 relationship: child_of NeXO:9952 ! CC: | BP: | MF: [Term] id: NeXO:9000 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.75186495017131 density:0.0953846153846154 bootstrap:0.256436298 cc_score:0.0 bp_score:0.071086 mf_score:0.0325059 relationship: child_of NeXO:9649 ! CC: | BP: | MF: [Term] id: NeXO:9905 name: CC: actin cortical patch | BP: actin cytoskeleton organization | MF:actin binding def: "CC_def: A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. | MF_def:Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [NeXO-GO:term] namespace: NeXO comment: robustness:15.7660133704164 density:0.117171717171717 bootstrap:0.477388657 cc_score:0.354699 bp_score:0.201769 mf_score:0.242143 relationship: child_of NeXO:9991 ! CC: cortical actin cytoskeleton | BP: actin filament-based process | MF:cytoskeletal protein binding [Term] id: NeXO:9902 name: CC: | BP: membrane budding | MF: def: "CC_def: | BP_def: The evagination of a membrane, resulting in formation of a vesicle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.20925054836868 density:0.147177419354839 bootstrap:0.1623992 cc_score:0.0496807 bp_score:0.103022 mf_score:0.0260865 relationship: child_of NeXO:9942 ! CC: | BP: | MF: [Term] id: NeXO:9903 name: CC: | BP: microautophagy | MF: def: "CC_def: | BP_def: The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.29407900994857 density:0.0742857142857143 bootstrap:0.171479485 cc_score:0.0 bp_score:0.116523 mf_score:0.0 relationship: child_of NeXO:9933 ! CC: | BP: | MF: [Term] id: NeXO:7043 name: CC: | BP: sphingolipid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5550691463107 density:0.214285714285714 bootstrap:0.539728897 cc_score:0.0 bp_score:0.139883 mf_score:0.0442608 relationship: child_of NeXO:7937 ! CC: | BP: pyrimidine base metabolic process | MF: [Term] id: NeXO:9901 name: CC: proteasome complex | BP: proteasome assembly | MF: def: "CC_def: A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. | BP_def: The aggregation, arrangement and bonding together of a mature, active proteasome complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.9176175810835 density:0.554878048780488 bootstrap:0.71627536 cc_score:0.620816 bp_score:0.297988 mf_score:0.0934858 relationship: child_of NeXO:9962 ! CC: | BP: modification-dependent protein catabolic process | MF: [Term] id: NeXO:7474 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.55376493405228 density:0.111111111111111 bootstrap:0.493403409 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8354 ! CC: | BP: | MF: [Term] id: NeXO:5693 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87671684 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6498 ! CC: | BP: negative regulation of lipid biosynthetic process | MF: [Term] id: NeXO:5690 name: CC: | BP: | MF:O-acetylhomoserine aminocarboxypropyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.0543846648912 density:1 bootstrap:0.69933518 cc_score:0.0 bp_score:0.0928764 mf_score:0.446582 relationship: child_of NeXO:6835 ! CC: | BP: | MF:adenylylsulfate kinase activity [Term] id: NeXO:5697 name: CC: | BP: histidine biosynthetic process | MF:ATP phosphoribosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | MF_def:Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.95507182117532 density:0.666666666666667 bootstrap:0.79580932 cc_score:0.0 bp_score:0.219956 mf_score:0.320301 relationship: child_of NeXO:5698 ! CC: | BP: pyrimidine nucleoside monophosphate biosynthetic process | MF:nucleoside kinase activity [Term] id: NeXO:5694 name: CC: | BP: protein homotetramerization | MF: def: "CC_def: | BP_def: The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.729782936 cc_score:0.0 bp_score:0.442025 mf_score:0.0 relationship: child_of NeXO:6099 ! CC: | BP: cytidine deamination | MF:cytidine deaminase activity [Term] id: NeXO:5695 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.895360285 cc_score:0.0 bp_score:0.0880856 mf_score:0.0 relationship: child_of NeXO:6951 ! CC: | BP: | MF: [Term] id: NeXO:5698 name: CC: | BP: pyrimidine nucleoside monophosphate biosynthetic process | MF:nucleoside kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. | MF_def:Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.14449425186663 density:0.266666666666667 bootstrap:0.58361491 cc_score:0.0 bp_score:0.179976 mf_score:0.207696 relationship: child_of NeXO:5892 ! CC: | BP: pyrimidine ribonucleotide biosynthetic process | MF:UMP biosynthetic process [Term] id: NeXO:5699 name: CC: | BP: | MF:inositol heptakisphosphate 5-kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.435503563 cc_score:0.0 bp_score:0.0 mf_score:0.321612 relationship: child_of NeXO:5820 ! CC: | BP: | MF:citrate hydro-lyase (cis-aconitate-forming) activity [Term] id: NeXO:8565 name: CC: | BP: response to redox state | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.08981643771013 density:1 bootstrap:0.71543273 cc_score:0.0 bp_score:0.219351 mf_score:0.0 relationship: child_of NeXO:9424 ! CC: | BP: | MF: relationship: linked_to NeXO:9017 ! CC: | BP: coenzyme transport | MF:4-hydroxybenzoate octaprenyltransferase activity relationship: linked_to NeXO:8769 ! CC: mitochondrial respiratory chain complex III | BP: mitochondrial electron transport, ubiquinol to cytochrome c | MF: relationship: linked_to NeXO:7895 ! CC: | BP: | MF: [Term] id: NeXO:6668 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.757833156 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7343 ! CC: nascent polypeptide-associated complex | BP: 'de novo' cotranslational protein folding | MF: [Term] id: NeXO:6669 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61089775 cc_score:0.0 bp_score:0.0 mf_score:0.0873402 relationship: child_of NeXO:7394 ! CC: | BP: | MF:metallochaperone activity [Term] id: NeXO:5091 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71989217 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5093 ! CC: | BP: | MF: [Term] id: NeXO:6662 name: CC: | BP: xenobiotic metabolic process | MF:gamma-glutamyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. | MF_def:Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [NeXO-GO:term] namespace: NeXO comment: robustness:1.97819492138599 density:1 bootstrap:0.64842539 cc_score:0.0 bp_score:0.296522 mf_score:0.443232 relationship: child_of NeXO:7373 ! CC: | BP: | MF: [Term] id: NeXO:6663 name: CC: | BP: | MF:alpha-tubulin binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75225865 cc_score:0.0 bp_score:0.0 mf_score:0.293341 relationship: child_of NeXO:7206 ! CC: | BP: | MF: [Term] id: NeXO:6660 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.49553997493365 density:1 bootstrap:0.370610653 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7349 ! CC: | BP: | MF: relationship: linked_to NeXO:7743 ! CC: | BP: arginine transport | MF:lysine transport [Term] id: NeXO:6661 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19394391265851 density:1 bootstrap:0.79757749 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8888 ! CC: Pwp2p-containing subcomplex of 90S preribosome | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:6667 name: CC: | BP: mannose biosynthetic process | MF:phosphomannomutase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. | MF_def:Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.834880175 cc_score:0.0 bp_score:0.232899 mf_score:0.441613 relationship: child_of NeXO:6967 ! CC: | BP: | MF:dolichol kinase activity [Term] id: NeXO:6664 name: CC: | BP: | MF:double-stranded RNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with double-stranded RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.47209497 cc_score:0.0 bp_score:0.0 mf_score:0.114819 relationship: child_of NeXO:7447 ! CC: | BP: | MF: [Term] id: NeXO:6665 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80413044 cc_score:0.0 bp_score:0.0476148 mf_score:0.0 relationship: child_of NeXO:7760 ! CC: | BP: | MF: [Term] id: NeXO:5968 name: CC: ion channel complex | BP: | MF: def: "CC_def: A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67828352 cc_score:0.203709 bp_score:0.058066 mf_score:0.0 relationship: child_of NeXO:6220 ! CC: | BP: isoleucyl-tRNA aminoacylation | MF:isoleucine-tRNA ligase activity [Term] id: NeXO:5585 name: CC: | BP: cellular hyperosmotic salinity response | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87833622 cc_score:0.0 bp_score:0.148096 mf_score:0.0560397 relationship: child_of NeXO:6454 ! CC: | BP: | MF: [Term] id: NeXO:5960 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.28951171695663 density:0.266666666666667 bootstrap:0.81709283 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7076 ! CC: | BP: | MF: [Term] id: NeXO:5961 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8254449 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7235 ! CC: | BP: | MF: [Term] id: NeXO:5962 name: CC: | BP: negative regulation of DNA-dependent DNA replication initiation | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.38134505985423 density:1 bootstrap:0.93965084 cc_score:0.0 bp_score:0.439329 mf_score:0.0 relationship: child_of NeXO:8302 ! CC: | BP: | MF: relationship: linked_to NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding relationship: linked_to NeXO:5452 ! CC: | BP: activation of mitotic anaphase-promoting complex activity | MF:mitotic anaphase-promoting complex activity relationship: linked_to NeXO:8525 ! CC: | BP: | MF: [Term] id: NeXO:5963 name: CC: | BP: positive regulation of nuclear mRNA splicing, via spliceosome | MF: def: "CC_def: | BP_def: Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17095956157363 density:1 bootstrap:0.78095375 cc_score:0.0 bp_score:0.294192 mf_score:0.0 relationship: child_of NeXO:6478 ! CC: | BP: positive regulation of mRNA processing | MF: [Term] id: NeXO:5964 name: CC: | BP: mitochondrial iron ion transport | MF:porphobilinogen synthase activity def: "CC_def: | BP_def: The directed movement of iron ions into, out of or within a mitochondrion. | MF_def:Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [NeXO-GO:term] namespace: NeXO comment: robustness:1.89852636352344 density:1 bootstrap:0.59724856 cc_score:0.0 bp_score:0.293095 mf_score:0.439297 relationship: child_of NeXO:5965 ! CC: | BP: | MF: [Term] id: NeXO:5965 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86497721659265 density:0.333333333333333 bootstrap:0.704248817 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6855 ! CC: | BP: | MF:flavin-linked sulfhydryl oxidase activity [Term] id: NeXO:5967 name: CC: | BP: carnitine metabolic process | MF:carnitine O-acetyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. | MF_def:Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79195042 cc_score:0.0 bp_score:0.218988 mf_score:0.221044 relationship: child_of NeXO:6495 ! CC: | BP: malate metabolic process | MF:L-malate dehydrogenase activity [Term] id: NeXO:7105 name: CC: mitochondrial oxoglutarate dehydrogenase complex | BP: 2-oxoglutarate metabolic process | MF:oxoglutarate dehydrogenase (succinyl-transferring) activity def: "CC_def: A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus. | BP_def: The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. | MF_def:Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:5.6110660784332 density:1 bootstrap:0.86947146 cc_score:0.656626 bp_score:0.531041 mf_score:0.446765 relationship: child_of NeXO:7106 ! CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: NeXO:5280 name: CC: | BP: regulation of cell budding | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the formation and growth of cell buds. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.37964872611487 density:1 bootstrap:0.93831261 cc_score:0.0 bp_score:0.295576 mf_score:0.0 relationship: child_of NeXO:6752 ! CC: | BP: | MF: [Term] id: NeXO:5347 name: CC: | BP: | MF:L-methionine transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81600791 cc_score:0.0 bp_score:0.0 mf_score:0.295134 relationship: child_of NeXO:6595 ! CC: | BP: | MF: [Term] id: NeXO:6732 name: CC: | BP: pyrimidine-containing compound transmembrane transport | MF:uracil:cation symporter activity def: "CC_def: | BP_def: The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.38711703623329 density:0.0476190476190476 bootstrap:0.638311921 cc_score:0.0 bp_score:0.129766 mf_score:0.119629 relationship: child_of NeXO:7253 ! CC: | BP: | MF: [Term] id: NeXO:6733 name: CC: | BP: age-dependent response to reactive oxygen species involved in chronological cell aging | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.509659262 cc_score:0.0 bp_score:0.297723 mf_score:0.0 relationship: child_of NeXO:7424 ! CC: | BP: cellular age-dependent response to reactive oxygen species | MF: [Term] id: NeXO:6285 name: CC: | BP: | MF:1-acylglycerol-3-phosphate O-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.03178576298351 density:0.1 bootstrap:0.284405235 cc_score:0.0 bp_score:0.0 mf_score:0.119106 relationship: child_of NeXO:6773 ! CC: | BP: | MF: [Term] id: NeXO:9120 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.50261757 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9245 ! CC: | BP: | MF: relationship: linked_to NeXO:9561 ! CC: | BP: | MF: [Term] id: NeXO:9121 name: CC: mitotic checkpoint complex | BP: | MF: def: "CC_def: A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39156026766743 density:0.5 bootstrap:0.378408105 cc_score:0.268542 bp_score:0.0328466 mf_score:0.0 relationship: child_of NeXO:9432 ! CC: | BP: mitotic cell cycle spindle checkpoint | MF: relationship: linked_to NeXO:8650 ! CC: condensed nuclear chromosome outer kinetochore | BP: establishment of meiotic sister chromatid cohesion | MF: [Term] id: NeXO:9122 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97657619834812 density:0.133333333333333 bootstrap:0.52533846 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9445 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:9123 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.63050816888245 density:0.133333333333333 bootstrap:0.339566544 cc_score:0.0 bp_score:0.0 mf_score:0.0760041 relationship: child_of NeXO:9410 ! CC: | BP: | MF: [Term] id: NeXO:6736 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.55657637752565 density:0.107142857142857 bootstrap:0.64999384 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6991 ! CC: | BP: | MF: [Term] id: NeXO:9126 name: CC: Nrd1 complex | BP: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled | MF:transcription regulatory region RNA binding def: "CC_def: A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p. | BP_def: Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled. | MF_def:Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.520056331 cc_score:0.218918 bp_score:0.440543 mf_score:0.292295 relationship: child_of NeXO:9616 ! CC: | BP: regulation of transcription termination, DNA-dependent | MF: relationship: linked_to NeXO:8176 ! CC: | BP: transcription termination, DNA-dependent | MF: relationship: linked_to NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:8632 ! CC: | BP: spermidine metabolic process | MF:pantothenate kinase activity relationship: linked_to NeXO:7952 ! CC: | BP: nuclear polyadenylation-dependent antisense transcript catabolic process | MF:5'-deoxyribose-5-phosphate lyase activity relationship: linked_to NeXO:8717 ! CC: | BP: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | MF: relationship: linked_to NeXO:9025 ! CC: | BP: mRNA splice site selection | MF:U1 snRNA binding [Term] id: NeXO:9127 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.51375853532336 density:1 bootstrap:0.68193347 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9506 ! CC: | BP: | MF: relationship: linked_to NeXO:9232 ! CC: | BP: | MF: [Term] id: NeXO:9128 name: CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity def: "CC_def: A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. | BP_def: | MF_def:An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [NeXO-GO:term] namespace: NeXO comment: robustness:2.79174056960775 density:0.666666666666667 bootstrap:0.363584794 cc_score:0.250135 bp_score:0.0 mf_score:0.253558 relationship: child_of NeXO:9469 ! CC: | BP: postreplication repair | MF: [Term] id: NeXO:9129 name: CC: clathrin coat | BP: | MF: def: "CC_def: A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.22602929222984 density:0.9 bootstrap:0.525058466 cc_score:0.19793 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9701 ! CC: | BP: | MF: [Term] id: NeXO:9284 name: CC: | BP: protein deacetylation | MF:histone deacetylase activity def: "CC_def: | BP_def: The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. | MF_def:Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [NeXO-GO:term] namespace: NeXO comment: robustness:1.62933650810606 density:0.0888888888888889 bootstrap:0.215709094 cc_score:0.0 bp_score:0.106706 mf_score:0.147017 relationship: child_of NeXO:9617 ! CC: | BP: nuclear polyadenylation-dependent rRNA catabolic process | MF: [Term] id: NeXO:5282 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.925013528 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6475 ! CC: extrinsic to mitochondrial outer membrane | BP: peroxidase activity | MF:phospholipid-hydroperoxide glutathione peroxidase activity [Term] id: NeXO:7919 name: CC: | BP: bilirubin transport | MF:glutathione S-conjugate-exporting ATPase activity def: "CC_def: | BP_def: The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.367962835 cc_score:0.0 bp_score:0.29745 mf_score:0.438276 relationship: child_of NeXO:8677 ! CC: | BP: sucrose mediated signaling | MF:bilirubin transmembrane transporter activity relationship: linked_to NeXO:6007 ! CC: | BP: antimonite transport | MF:bile acid transmembrane transporter activity [Term] id: NeXO:7918 name: CC: polarisome | BP: positive regulation of Rab GTPase activity | MF:Rab GTPase activator activity def: "CC_def: Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. | BP_def: Any process that activates or increases the activity of a GTPase of the Rab family. | MF_def:Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [NeXO-GO:term] namespace: NeXO comment: robustness:2.04649783610811 density:1 bootstrap:0.69397596 cc_score:0.250473 bp_score:0.150364 mf_score:0.162909 relationship: child_of NeXO:8492 ! CC: | BP: regulation of Rab GTPase activity | MF: [Term] id: NeXO:6551 name: CC: | BP: endocytic recycling | MF: def: "CC_def: | BP_def: The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.3318174 cc_score:0.0 bp_score:0.219511 mf_score:0.0 relationship: child_of NeXO:7144 ! CC: | BP: | MF: [Term] id: NeXO:5589 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.96968436 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6948 ! CC: | BP: | MF: [Term] id: NeXO:7913 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.412865157 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8150 ! CC: | BP: | MF: [Term] id: NeXO:7912 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.8994968515339 density:0.166666666666667 bootstrap:0.19040947 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8476 ! CC: | BP: | MF: [Term] id: NeXO:7911 name: CC: | BP: detection of sucrose stimulus | MF:diacylglycerol cholinephosphotransferase activity def: "CC_def: | BP_def: The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal. | MF_def:Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.365953724 cc_score:0.0 bp_score:0.441454 mf_score:0.29607 relationship: child_of NeXO:8677 ! CC: | BP: sucrose mediated signaling | MF:bilirubin transmembrane transporter activity relationship: linked_to NeXO:5791 ! CC: | BP: | MF:ethanolaminephosphotransferase activity [Term] id: NeXO:7910 name: CC: | BP: | MF:cystathionine gamma-synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.685438276 cc_score:0.0 bp_score:0.0 mf_score:0.219922 relationship: child_of NeXO:8089 ! CC: | BP: | MF: [Term] id: NeXO:7917 name: CC: | BP: D-serine metabolic process | MF:D-serine ammonia-lyase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. | MF_def:Catalysis of the reaction: D-serine = pyruvate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:5.05311638477246 density:1 bootstrap:0.70515269 cc_score:0.0 bp_score:0.219894 mf_score:0.222676 relationship: child_of NeXO:8180 ! CC: | BP: | MF: [Term] id: NeXO:7916 name: CC: | BP: | MF:glucose-6-phosphate isomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.711273937 cc_score:0.0 bp_score:0.0237183 mf_score:0.44166 relationship: child_of NeXO:9400 ! CC: | BP: glucose catabolic process to ethanol | MF:methylglyoxal reductase (NADH-dependent) activity [Term] id: NeXO:7915 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.723646814 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8151 ! CC: | BP: | MF: relationship: linked_to NeXO:5792 ! CC: | BP: | MF: [Term] id: NeXO:7914 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.940108991117636 density:0.0666666666666667 bootstrap:0.264320847 cc_score:0.0 bp_score:0.0256926 mf_score:0.0 relationship: child_of NeXO:8829 ! CC: | BP: | MF: [Term] id: NeXO:7980 name: CC: | BP: nuclear mRNA 3'-splice site recognition | MF: def: "CC_def: | BP_def: Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.39091970918426 density:1 bootstrap:0.80258362 cc_score:0.0670113 bp_score:0.114508 mf_score:0.0 relationship: child_of NeXO:9150 ! CC: | BP: | MF: relationship: linked_to NeXO:8813 ! CC: Prp19 complex | BP: | MF:first spliceosomal transesterification activity [Term] id: NeXO:6288 name: CC: | BP: phospholipid catabolic process | MF:phospholipase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. | MF_def:Catalysis of the hydrolysis of a glycerophospholipid." [NeXO-GO:term] namespace: NeXO comment: robustness:2.55934595562029 density:0.333333333333333 bootstrap:0.69918626 cc_score:0.0 bp_score:0.130217 mf_score:0.100888 relationship: child_of NeXO:7003 ! CC: | BP: | MF: [Term] id: NeXO:6289 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68418008 cc_score:0.0 bp_score:0.0333841 mf_score:0.0 relationship: child_of NeXO:7536 ! CC: | BP: glycogen catabolic process | MF:glycogen phosphorylase activity relationship: linked_to NeXO:8655 ! CC: | BP: | MF:bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: NeXO:7981 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.814712742956691 density:0.00529100529100529 bootstrap:0.450575348 cc_score:0.0 bp_score:0.0 mf_score:0.0277341 relationship: child_of NeXO:9405 ! CC: | BP: | MF: [Term] id: NeXO:6284 name: CC: | BP: | MF:1-acylglycerophosphocholine O-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:1.50846379430899 density:0.333333333333333 bootstrap:0.460732498 cc_score:0.0 bp_score:0.0 mf_score:0.231274 relationship: child_of NeXO:6285 ! CC: | BP: | MF:1-acylglycerol-3-phosphate O-acyltransferase activity [Term] id: NeXO:5581 name: CC: | BP: defense response | MF: def: "CC_def: | BP_def: Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.78665537532294 density:0.333333333333333 bootstrap:0.828898629 cc_score:0.0 bp_score:0.250145 mf_score:0.0228068 relationship: child_of NeXO:6768 ! CC: | BP: | MF: [Term] id: NeXO:6286 name: CC: | BP: medium-chain fatty acid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85326886 cc_score:0.0 bp_score:0.219792 mf_score:0.071528 relationship: child_of NeXO:6287 ! CC: | BP: phospholipase activity | MF:lysophospholipase activity [Term] id: NeXO:6287 name: CC: | BP: phospholipase activity | MF:lysophospholipase activity def: "CC_def: | BP_def: Catalysis of the hydrolysis of a glycerophospholipid. | MF_def:Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.02534940970681 density:0.666666666666667 bootstrap:0.83411133 cc_score:0.0 bp_score:0.2807 mf_score:0.341834 relationship: child_of NeXO:6288 ! CC: | BP: phospholipid catabolic process | MF:phospholipase activity [Term] id: NeXO:6280 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23293079957079 density:1 bootstrap:0.82617562 cc_score:0.0 bp_score:0.0569139 mf_score:0.0 relationship: child_of NeXO:6423 ! CC: | BP: | MF: [Term] id: NeXO:6281 name: CC: | BP: osmosensory signaling pathway via two-component system | MF:protein histidine kinase binding def: "CC_def: | BP_def: A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system. | MF_def:Interacting selectively and non-covalently with protein histidine kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:2.17793902375761 density:1 bootstrap:0.78598323 cc_score:0.0 bp_score:0.446193 mf_score:0.439636 relationship: child_of NeXO:7093 ! CC: | BP: protein histidine kinase activity | MF:histidine phosphotransfer kinase activity relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity relationship: linked_to NeXO:7818 ! CC: | BP: activation of MAPKKK activity involved in osmosensory signaling pathway | MF:mitogen-activated protein kinase kinase kinase binding [Term] id: NeXO:6282 name: CC: | BP: | MF:L-ascorbic acid binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.51209977 cc_score:0.0 bp_score:0.0210727 mf_score:0.440694 relationship: child_of NeXO:6997 ! CC: | BP: | MF: [Term] id: NeXO:6283 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.448801518 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6284 ! CC: | BP: | MF:1-acylglycerophosphocholine O-acyltransferase activity [Term] id: NeXO:6042 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.80185858879928 density:1 bootstrap:0.92960584 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6166 ! CC: | BP: | MF: [Term] id: NeXO:8602 name: CC: | BP: thiamine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.40080023130007 density:0.0784313725490196 bootstrap:0.352622447 cc_score:0.0 bp_score:0.100641 mf_score:0.0 relationship: child_of NeXO:9444 ! CC: | BP: | MF: [Term] id: NeXO:6040 name: CC: | BP: cell wall macromolecule catabolic process | MF:endo-1,3(4)-beta-glucanase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. | MF_def:Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.559982935 cc_score:0.0 bp_score:0.220199 mf_score:0.29249 relationship: child_of NeXO:6785 ! CC: | BP: | MF: [Term] id: NeXO:6041 name: CC: | BP: positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF:sequence-specific enhancer binding RNA polymerase II transcription factor activity def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.843011652 cc_score:0.0 bp_score:0.181351 mf_score:0.143239 relationship: child_of NeXO:7533 ! CC: | BP: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: [Term] id: NeXO:6047 name: CC: | BP: GO:0061395 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27851114524679 density:1 bootstrap:0.86024897 cc_score:0.0 bp_score:0.441348 mf_score:0.0 relationship: child_of NeXO:6048 ! CC: | BP: cellular response to arsenic-containing substance | MF:hexitol dehydrogenase activity [Term] id: NeXO:6044 name: CC: | BP: intron homing | MF: def: "CC_def: | BP_def: Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.24010348276193 density:1 bootstrap:0.831491874 cc_score:0.0 bp_score:0.173409 mf_score:0.0 relationship: child_of NeXO:7744 ! CC: | BP: Group I intron splicing | MF: relationship: linked_to NeXO:6045 ! CC: | BP: | MF: [Term] id: NeXO:6045 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.814936876 cc_score:0.0 bp_score:0.014091 mf_score:0.0 relationship: child_of NeXO:7744 ! CC: | BP: Group I intron splicing | MF: [Term] id: NeXO:7984 name: CC: | BP: clathrin coat disassembly | MF:homoisocitrate dehydrogenase activity def: "CC_def: | BP_def: The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. | MF_def:Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.266053606 cc_score:0.0 bp_score:0.314351 mf_score:0.269278 relationship: child_of NeXO:8839 ! CC: | BP: | MF: [Term] id: NeXO:6048 name: CC: | BP: cellular response to arsenic-containing substance | MF:hexitol dehydrogenase activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. | MF_def:Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:2.58379219034927 density:0.2 bootstrap:0.80665203 cc_score:0.0 bp_score:0.119471 mf_score:0.118669 relationship: child_of NeXO:6877 ! CC: | BP: | MF: [Term] id: NeXO:6049 name: CC: | BP: amide biosynthetic process | MF:cyclo-ligase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. | MF_def:Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35466001849237 density:0.2 bootstrap:0.66992701 cc_score:0.0 bp_score:0.162186 mf_score:0.116297 relationship: child_of NeXO:6604 ! CC: | BP: | MF: [Term] id: NeXO:8600 name: CC: | BP: cotranslational protein targeting to membrane | MF: def: "CC_def: | BP_def: The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.01338352311793 density:0.393939393939394 bootstrap:0.558077054 cc_score:0.0 bp_score:0.164903 mf_score:0.0913466 relationship: child_of NeXO:9399 ! CC: | BP: | MF: [Term] id: NeXO:6482 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.784441158 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7453 ! CC: | BP: | MF: [Term] id: NeXO:8084 name: CC: | BP: charged-tRNA amino acid modification | MF: def: "CC_def: | BP_def: The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.22624933195839 density:0.166666666666667 bootstrap:0.353872502 cc_score:0.0 bp_score:0.166978 mf_score:0.0 relationship: child_of NeXO:8714 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:6984 name: CC: early endosome | BP: early endosome to Golgi transport | MF: def: "CC_def: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. | BP_def: The directed movement of substances from early endosomes to the Golgi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.04725896483006 density:0.933333333333333 bootstrap:0.79178909 cc_score:0.130613 bp_score:0.190454 mf_score:0.0 relationship: child_of NeXO:7438 ! CC: cis-Golgi network membrane | BP: | MF: [Term] id: NeXO:9405 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86587050570108 density:0.007168458781362 bootstrap:0.43867769 cc_score:0.0 bp_score:0.0233428 mf_score:0.0131766 relationship: child_of NeXO:9854 ! CC: | BP: | MF: [Term] id: NeXO:8085 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49926813 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8350 ! CC: | BP: | MF: [Term] id: NeXO:6983 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.642367014 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7811 ! CC: | BP: | MF: [Term] id: NeXO:9404 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62421822422824 density:0.0404858299595142 bootstrap:0.219928145 cc_score:0.0 bp_score:0.0331685 mf_score:0.0 relationship: child_of NeXO:9785 ! CC: | BP: | MF: [Term] id: NeXO:6982 name: CC: | BP: branched chain family amino acid catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.35852693041922 density:0.138888888888889 bootstrap:0.648361403 cc_score:0.0 bp_score:0.144864 mf_score:0.0790436 relationship: child_of NeXO:8171 ! CC: | BP: | MF: [Term] id: NeXO:9582 name: CC: U2-type prespliceosome | BP: spliceosome assembly | MF: def: "CC_def: A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. | BP_def: The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.897909685049 density:0.533333333333333 bootstrap:0.311431227 cc_score:0.439922 bp_score:0.144882 mf_score:0.0655594 relationship: child_of NeXO:9618 ! CC: commitment complex | BP: | MF: [Term] id: NeXO:7350 name: CC: | BP: trehalose metabolic process | MF:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. | MF_def:Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.19347876585729 density:0.2 bootstrap:0.40073257 cc_score:0.0 bp_score:0.171806 mf_score:0.226244 relationship: child_of NeXO:8020 ! CC: | BP: | MF:carbohydrate phosphatase activity [Term] id: NeXO:5108 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80718463 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5122 ! CC: | BP: | MF: [Term] id: NeXO:5109 name: CC: | BP: meiotic gene conversion | MF:3'-tyrosyl-DNA phosphodiesterase activity def: "CC_def: | BP_def: The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele. | MF_def:Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.481347074 cc_score:0.0 bp_score:0.182966 mf_score:0.202805 relationship: child_of NeXO:5208 ! CC: | BP: | MF: [Term] id: NeXO:7355 name: CC: | BP: CTP biosynthetic process | MF:CTP synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. | MF_def:Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79990044 cc_score:0.0 bp_score:0.221219 mf_score:0.292126 relationship: child_of NeXO:7713 ! CC: | BP: pyrimidine nucleoside triphosphate metabolic process | MF:poly(A) RNA binding [Term] id: NeXO:9587 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.72446022759627 density:1 bootstrap:0.5429753 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9788 ! CC: | BP: | MF: [Term] id: NeXO:9584 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.4704236373007 density:0.928571428571429 bootstrap:0.475181358 cc_score:0.0 bp_score:0.013113 mf_score:0.0 relationship: child_of NeXO:9841 ! CC: | BP: response to acid | MF: [Term] id: NeXO:7356 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23926118004971 density:1 bootstrap:0.830866692 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8383 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7359 name: CC: | BP: DNA replication preinitiation complex assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication, by the assembly of additional proteins onto an existing prereplicative complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.33857176 cc_score:0.0 bp_score:0.168318 mf_score:0.047658 relationship: child_of NeXO:7994 ! CC: | BP: | MF: [Term] id: NeXO:7358 name: CC: | BP: mitotic cell cycle G2/M transition DNA damage checkpoint | MF: def: "CC_def: | BP_def: A mitotic cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.824169501 cc_score:0.0 bp_score:0.440453 mf_score:0.0 relationship: child_of NeXO:7771 ! CC: | BP: | MF: [Term] id: NeXO:5100 name: CC: | BP: acetate transport | MF:acetate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85459049 cc_score:0.0 bp_score:0.294132 mf_score:0.443755 relationship: child_of NeXO:6302 ! CC: | BP: | MF:organic anion transmembrane transporter activity [Term] id: NeXO:5101 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85240453 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8552 ! CC: | BP: | MF: [Term] id: NeXO:5106 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86162236 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6429 ! CC: | BP: | MF: [Term] id: NeXO:9409 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53833318131794 density:0.666666666666667 bootstrap:0.300574996 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9642 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: relationship: linked_to NeXO:9697 ! CC: | BP: | MF: [Term] id: NeXO:5104 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91424578 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5395 ! CC: | BP: | MF:sodium:inorganic phosphate symporter activity [Term] id: NeXO:5105 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82292548 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5369 ! CC: | BP: | MF: [Term] id: NeXO:5830 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85096561 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6726 ! CC: | BP: | MF: [Term] id: NeXO:7574 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.538131355 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8517 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:5831 name: CC: | BP: | MF:adenyl-nucleotide exchange factor activity def: "CC_def: | BP_def: | MF_def:Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8182836 cc_score:0.0 bp_score:0.0 mf_score:0.126736 relationship: child_of NeXO:6703 ! CC: signal peptidase complex | BP: signal peptide processing | MF: [Term] id: NeXO:5975 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91099981 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6116 ! CC: | BP: | MF: [Term] id: NeXO:9818 name: CC: | BP: cellular response to osmotic stress | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.66159539470311 density:0.112643678160920 bootstrap:0.219030189 cc_score:0.0 bp_score:0.174795 mf_score:0.010752 relationship: child_of NeXO:9898 ! CC: | BP: cellular response to abiotic stimulus | MF: [Term] id: NeXO:5652 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75733036 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5825 ! CC: | BP: | MF:phosphoglycolate phosphatase activity [Term] id: NeXO:5435 name: CC: RecQ helicase-Topo III complex | BP: positive regulation of DNA binding | MF:DNA topoisomerase type I activity def: "CC_def: A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human. | BP_def: Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). | MF_def:Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [NeXO-GO:term] namespace: NeXO comment: robustness:3.16189334128718 density:0.666666666666667 bootstrap:0.91110278 cc_score:0.423388 bp_score:0.138698 mf_score:0.236734 relationship: child_of NeXO:5581 ! CC: | BP: defense response | MF: [Term] id: NeXO:8756 name: CC: eukaryotic translation initiation factor 4F complex | BP: stress granule assembly | MF: def: "CC_def: The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. | BP_def: The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.04492768260744 density:1 bootstrap:0.90369047 cc_score:0.525112 bp_score:0.219585 mf_score:0.0 relationship: child_of NeXO:9616 ! CC: | BP: regulation of transcription termination, DNA-dependent | MF: relationship: linked_to NeXO:9025 ! CC: | BP: mRNA splice site selection | MF:U1 snRNA binding relationship: linked_to NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:8312 ! CC: | BP: | MF: [Term] id: NeXO:5216 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.40293288860307 density:1 bootstrap:0.95676467 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6009 ! CC: | BP: | MF: [Term] id: NeXO:5217 name: CC: | BP: protein stabilization | MF: def: "CC_def: | BP_def: Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.879933989 cc_score:0.0 bp_score:0.113249 mf_score:0.0 relationship: child_of NeXO:5430 ! CC: | BP: | MF: [Term] id: NeXO:5214 name: CC: | BP: beta-alanine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29693187273977 density:1 bootstrap:0.87421464 cc_score:0.0 bp_score:0.875455 mf_score:0.0 relationship: child_of NeXO:5215 ! CC: | BP: polyamine catabolic process | MF:aldehyde dehydrogenase [NAD(P)+] activity [Term] id: NeXO:5215 name: CC: | BP: polyamine catabolic process | MF:aldehyde dehydrogenase [NAD(P)+] activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. | MF_def:Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.08539647377593 density:0.333333333333333 bootstrap:0.88055469 cc_score:0.0 bp_score:0.315948 mf_score:0.409094 relationship: child_of NeXO:5480 ! CC: | BP: cellular biogenic amine catabolic process | MF: [Term] id: NeXO:5213 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85912217 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5463 ! CC: | BP: | MF: [Term] id: NeXO:5210 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.16517609547869 density:0.666666666666667 bootstrap:0.91299562 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5728 ! CC: | BP: protein O-linked glycosylation | MF:dolichyl-phosphate-mannose-protein mannosyltransferase activity [Term] id: NeXO:5211 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82969225 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5392 ! CC: | BP: | MF: [Term] id: NeXO:9050 name: CC: | BP: protection from non-homologous end joining at telomere | MF: def: "CC_def: | BP_def: A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.295756193 cc_score:0.0 bp_score:0.439694 mf_score:0.0598792 relationship: child_of NeXO:9434 ! CC: | BP: positive regulation of transcription regulatory region DNA binding | MF:core RNA polymerase II recruiting transcription factor activity relationship: linked_to NeXO:7675 ! CC: | BP: | MF: [Term] id: NeXO:9051 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.735491482 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9393 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: [Term] id: NeXO:9052 name: CC: | BP: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery | MF: def: "CC_def: | BP_def: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.8215868154062 density:0.666666666666667 bootstrap:0.72553735 cc_score:0.0 bp_score:0.143256 mf_score:0.0 relationship: child_of NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: relationship: linked_to NeXO:8376 ! CC: Nup107-160 complex | BP: snRNA export from nucleus | MF: relationship: linked_to NeXO:8549 ! CC: | BP: poly(A)+ mRNA export from nucleus | MF: relationship: linked_to NeXO:9551 ! CC: | BP: | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity relationship: linked_to NeXO:8641 ! CC: | BP: regulation of mRNA export from nucleus in response to heat stress | MF: [Term] id: NeXO:9054 name: CC: | BP: tRNA re-export from nucleus | MF: def: "CC_def: | BP_def: The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.241699593 cc_score:0.0 bp_score:0.231361 mf_score:0.0 relationship: child_of NeXO:9543 ! CC: | BP: | MF:RNA guanylyltransferase activity [Term] id: NeXO:9055 name: CC: Arp2/3 protein complex | BP: regulation of actin filament polymerization | MF: def: "CC_def: A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. | BP_def: Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.79241991646319 density:1 bootstrap:0.75658631 cc_score:0.767866 bp_score:0.361237 mf_score:0.0 relationship: child_of NeXO:9275 ! CC: | BP: actin filament polymerization | MF: [Term] id: NeXO:5218 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85545958 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6392 ! CC: | BP: long-chain fatty acid metabolic process | MF:very long-chain fatty acid-CoA ligase activity [Term] id: NeXO:9057 name: CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.55908671751302 density:0.333333333333333 bootstrap:0.259463002 cc_score:0.0 bp_score:0.0 mf_score:0.164034 relationship: child_of NeXO:9731 ! CC: nuclear ubiquitin ligase complex | BP: | MF: relationship: linked_to NeXO:7751 ! CC: | BP: | MF: relationship: linked_to NeXO:7025 ! CC: | BP: | MF:[cytochrome c]-lysine N-methyltransferase activity [Term] id: NeXO:9887 name: CC: small-subunit processome | BP: rRNA 5'-end processing | MF:snoRNA binding def: "CC_def: A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. | BP_def: Any process involved in forming the mature 5' end of an rRNA molecule. | MF_def:Interacting selectively and non-covalently with small nucleolar RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:21.4392386381022 density:0.56 bootstrap:0.62684446 cc_score:0.38082 bp_score:0.199185 mf_score:0.368215 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: [Term] id: NeXO:9886 name: CC: condensed nuclear chromosome kinetochore | BP: mitotic sister chromatid cohesion | MF: def: "CC_def: A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules. | BP_def: The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.310514915135 density:0.292436974789916 bootstrap:0.382587941 cc_score:0.213983 bp_score:0.220448 mf_score:0.0 relationship: child_of NeXO:9919 ! CC: condensed chromosome kinetochore | BP: sister chromatid segregation | MF: [Term] id: NeXO:8927 name: CC: | BP: aromatic amino acid family biosynthetic process | MF:carbon-oxygen lyase activity, acting on phosphates def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). | MF_def:Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:9.42637141397473 density:0.333333333333333 bootstrap:0.604174313 cc_score:0.0 bp_score:0.221714 mf_score:0.103242 relationship: child_of NeXO:9145 ! CC: | BP: dicarboxylic acid metabolic process | MF: [Term] id: NeXO:8925 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.34292058164848 density:0.0471014492753623 bootstrap:0.190495879 cc_score:0.0 bp_score:0.0379299 mf_score:0.072478 relationship: child_of NeXO:9646 ! CC: | BP: | MF: [Term] id: NeXO:8924 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79877364142396 density:1 bootstrap:0.536135885 cc_score:0.0 bp_score:0.0783429 mf_score:0.0 relationship: child_of NeXO:9474 ! CC: | BP: transcription elongation from RNA polymerase II promoter | MF: relationship: linked_to NeXO:6010 ! CC: | BP: regulation of DNA replication involved in S phase | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:8922 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.89786057210676 density:1 bootstrap:0.46382393 cc_score:0.0 bp_score:0.0132646 mf_score:0.0 relationship: child_of NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: relationship: linked_to NeXO:9340 ! CC: | BP: | MF: [Term] id: NeXO:8921 name: CC: | BP: nitrogen catabolite repression of transcription from RNA polymerase II promoter | MF:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription def: "CC_def: | BP_def: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. | MF_def:Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9428460338729 density:1 bootstrap:0.62545867 cc_score:0.0 bp_score:0.444779 mf_score:0.125715 relationship: child_of NeXO:9330 ! CC: | BP: negative regulation of G1/S transition of mitotic cell cycle | MF: relationship: linked_to NeXO:8520 ! CC: | BP: | MF: [Term] id: NeXO:8920 name: CC: | BP: negative regulation of chromatin silencing at silent mating-type cassette | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.2542330630972 density:0.964285714285714 bootstrap:0.79345975 cc_score:0.0 bp_score:0.28467 mf_score:0.0191117 relationship: child_of NeXO:9764 ! CC: Rpd3L complex | BP: negative regulation of chromatin silencing at rDNA | MF:deacetylase activity [Term] id: NeXO:6486 name: CC: | BP: D-ribose metabolic process | MF:ribokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. | MF_def:Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72030927 cc_score:0.0 bp_score:0.11634 mf_score:0.439737 relationship: child_of NeXO:7204 ! CC: | BP: | MF:amylo-alpha-1,6-glucosidase activity [Term] id: NeXO:7500 name: CC: | BP: translational frameshifting | MF: def: "CC_def: | BP_def: A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.77994165200827 density:0.666666666666667 bootstrap:0.70427829 cc_score:0.0 bp_score:0.160541 mf_score:0.0 relationship: child_of NeXO:8166 ! CC: | BP: | MF:5-aminolevulinate synthase activity [Term] id: NeXO:5447 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.735519052 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6167 ! CC: | BP: | MF: relationship: linked_to NeXO:8277 ! CC: | BP: | MF: [Term] id: NeXO:8929 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69256408 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9773 ! CC: | BP: | MF: [Term] id: NeXO:7502 name: CC: Golgi cisterna | BP: regulation of ARF protein signal transduction | MF: def: "CC_def: Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. | BP_def: Any process that modulates the frequency, rate or extent of ARF protein signal transduction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.8304013179743 density:0.3 bootstrap:0.60097835 cc_score:0.150521 bp_score:0.112228 mf_score:0.0 relationship: child_of NeXO:8640 ! CC: trans-Golgi network transport vesicle | BP: cell wall polysaccharide biosynthetic process | MF: [Term] id: NeXO:5415 name: CC: GO:0097196 | BP: maintenance of rDNA | MF: def: "CC_def: | BP_def: Any process involved in sustaining the fidelity and copy number of rDNA repeats. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.69726430868686 density:0.5 bootstrap:0.90439628 cc_score:0.815674 bp_score:0.352752 mf_score:0.0 relationship: child_of NeXO:5766 ! CC: | BP: DNA biosynthetic process | MF: [Term] id: NeXO:8287 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.2643086970298 density:0.5 bootstrap:0.704985549 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8674 ! CC: | BP: | MF: relationship: linked_to NeXO:9251 ! CC: | BP: | MF: [Term] id: NeXO:7503 name: CC: cell septum | BP: | MF:glucan endo-1,3-beta-D-glucosidase activity def: "CC_def: A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. | BP_def: | MF_def:Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans." [NeXO-GO:term] namespace: NeXO comment: robustness:1.69144426119648 density:1 bootstrap:0.474064275 cc_score:0.219463 bp_score:0.0 mf_score:0.178903 relationship: child_of NeXO:8400 ! CC: | BP: | MF: relationship: linked_to NeXO:8835 ! CC: | BP: regulation of G-protein coupled receptor protein signaling pathway | MF:peptide-methionine (R)-S-oxide reductase activity relationship: linked_to NeXO:8546 ! CC: | BP: negative regulation of glycogen catabolic process | MF: [Term] id: NeXO:7638 name: CC: | BP: regulation of translation in response to stress | MF: def: "CC_def: | BP_def: Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3130848711747 density:0.166666666666667 bootstrap:0.245542878 cc_score:0.0 bp_score:0.119161 mf_score:0.0 relationship: child_of NeXO:8244 ! CC: endoplasmic reticulum palmitoyltransferase complex | BP: | MF: [Term] id: NeXO:7100 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91924770201241 density:0.5 bootstrap:0.563818945 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7639 ! CC: | BP: | MF: [Term] id: NeXO:7102 name: CC: extrinsic to fungal-type vacuolar membrane | BP: cellular response to amino acid starvation | MF: def: "CC_def: Loosely bound to one surface of the fungal-type vacuolar membrane, but not integrated into the hydrophobic region. | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.4913080649911 density:0.666666666666667 bootstrap:0.94102527 cc_score:0.534883 bp_score:0.256998 mf_score:0.0 relationship: child_of NeXO:8625 ! CC: extrinsic to vacuolar membrane | BP: | MF: [Term] id: NeXO:7103 name: CC: | BP: nucleotide-excision repair, DNA incision, 3'-to lesion | MF: def: "CC_def: | BP_def: The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.63789078926546 density:0.166666666666667 bootstrap:0.63133393 cc_score:0.0 bp_score:0.265677 mf_score:0.0 relationship: child_of NeXO:7104 ! CC: core TFIIH complex | BP: nucleotide-excision repair, DNA incision | MF: [Term] id: NeXO:7104 name: CC: core TFIIH complex | BP: nucleotide-excision repair, DNA incision | MF: def: "CC_def: The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34. | BP_def: A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.6965655020349 density:0.4 bootstrap:0.72666096 cc_score:0.274588 bp_score:0.222877 mf_score:0.0 relationship: child_of NeXO:8395 ! CC: | BP: | MF: [Term] id: NeXO:6869 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22221191413707 density:0.666666666666667 bootstrap:0.450032505 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7530 ! CC: | BP: | MF: relationship: linked_to NeXO:8575 ! CC: | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: [Term] id: NeXO:7106 name: CC: | BP: | MF:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [NeXO-GO:term] namespace: NeXO comment: robustness:4.92593629628961 density:0.244444444444444 bootstrap:0.558829908 cc_score:0.0 bp_score:0.0853392 mf_score:0.138007 relationship: child_of NeXO:7936 ! CC: | BP: | MF: [Term] id: NeXO:7107 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.571496279 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8249 ! CC: | BP: | MF: [Term] id: NeXO:7108 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45525768649093 density:0.0666666666666667 bootstrap:0.633366091 cc_score:0.0 bp_score:0.0796718 mf_score:0.0150177 relationship: child_of NeXO:8035 ! CC: | BP: | MF:DNA N-glycosylase activity [Term] id: NeXO:7109 name: CC: ER-Golgi intermediate compartment | BP: COPI coating of Golgi vesicle | MF:ARF GTPase activator activity def: "CC_def: | BP_def: The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. | MF_def:Increases the rate of GTP hydrolysis by the GTPase ARF." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64998265 cc_score:0.181585 bp_score:0.444241 mf_score:0.125659 relationship: child_of NeXO:7584 ! CC: | BP: Golgi vesicle budding | MF: [Term] id: NeXO:6866 name: CC: | BP: retrograde transport, vesicle recycling within Golgi | MF: def: "CC_def: | BP_def: The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09521570163584 density:1 bootstrap:0.7274101 cc_score:0.0 bp_score:0.303746 mf_score:0.0103967 relationship: child_of NeXO:7298 ! CC: Golgi cisterna membrane | BP: inositol phosphorylceramide metabolic process | MF:inositol phosphoceramide synthase activity [Term] id: NeXO:6867 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.885263281 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7345 ! CC: | BP: | MF: [Term] id: NeXO:6860 name: CC: DNA replication factor C complex | BP: | MF: def: "CC_def: A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94515522686647 density:1 bootstrap:0.85965931 cc_score:0.526904 bp_score:0.0722587 mf_score:0.0186323 relationship: child_of NeXO:8067 ! CC: Rad17 RFC-like complex | BP: isopentenyl diphosphate biosynthetic process, mevalonate pathway | MF:DNA clamp loader activity relationship: linked_to NeXO:9308 ! CC: Elg1 RFC-like complex | BP: | MF: [Term] id: NeXO:6861 name: CC: | BP: | MF:diacetyl reductase ((R)-acetoin forming) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.65882494 cc_score:0.0 bp_score:0.0 mf_score:0.201219 relationship: child_of NeXO:7435 ! CC: | BP: | MF: [Term] id: NeXO:6862 name: CC: | BP: peptidyl-lysine modification to hypusine | MF:deoxyhypusine monooxygenase activity def: "CC_def: | BP_def: The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. | MF_def:Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:1.93291655382841 density:1 bootstrap:0.61908183 cc_score:0.0 bp_score:0.175852 mf_score:0.439795 relationship: child_of NeXO:6863 ! CC: | BP: | MF: [Term] id: NeXO:6863 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.35145695108735 density:0.1 bootstrap:0.487936107 cc_score:0.0 bp_score:0.056209 mf_score:0.0 relationship: child_of NeXO:8014 ! CC: | BP: | MF: [Term] id: NeXO:5362 name: CC: | BP: lipase activity | MF: def: "CC_def: | BP_def: Catalysis of the hydrolysis of a lipid or phospholipid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93369801 cc_score:0.0 bp_score:0.109405 mf_score:0.0 relationship: child_of NeXO:6500 ! CC: | BP: | MF:structural constituent of cell wall [Term] id: NeXO:7351 name: CC: | BP: | MF:histone demethylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the removal of a methyl group from a histone." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69496765 cc_score:0.0 bp_score:0.0116275 mf_score:0.272345 relationship: child_of NeXO:8406 ! CC: | BP: | MF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: NeXO:5360 name: CC: | BP: protein arginylation | MF:arginyltransferase activity def: "CC_def: | BP_def: The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. | MF_def:Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85452817 cc_score:0.0 bp_score:0.437691 mf_score:0.446759 relationship: child_of NeXO:5435 ! CC: RecQ helicase-Topo III complex | BP: positive regulation of DNA binding | MF:DNA topoisomerase type I activity [Term] id: NeXO:5361 name: CC: | BP: | MF:transketolase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87549277 cc_score:0.0 bp_score:0.0 mf_score:0.298396 relationship: child_of NeXO:5802 ! CC: | BP: pentose-phosphate shunt | MF:ribulose-phosphate 3-epimerase activity [Term] id: NeXO:5366 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.47143257649084 density:0.6 bootstrap:0.64763915 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5367 ! CC: | BP: telomere maintenance via recombination | MF:DNA helicase activity [Term] id: NeXO:5367 name: CC: | BP: telomere maintenance via recombination | MF:DNA helicase activity def: "CC_def: | BP_def: Any recombinational process that contributes to the maintenance of proper telomeric length. | MF_def:Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [NeXO-GO:term] namespace: NeXO comment: robustness:7.54435595075724 density:0.571428571428571 bootstrap:0.95098085 cc_score:0.0464005 bp_score:0.280206 mf_score:0.158451 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:5364 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79409808 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5367 ! CC: | BP: telomere maintenance via recombination | MF:DNA helicase activity relationship: linked_to NeXO:5365 ! CC: | BP: | MF: [Term] id: NeXO:9583 name: CC: | BP: polyol transport | MF: def: "CC_def: | BP_def: The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.6460892483932 density:0.511111111111111 bootstrap:0.402214892 cc_score:0.0 bp_score:0.104615 mf_score:0.0811056 relationship: child_of NeXO:9820 ! CC: | BP: vesicle targeting, to, from or within Golgi | MF: [Term] id: NeXO:9270 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.30914732621158 density:0.8 bootstrap:0.600303477 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9627 ! CC: | BP: | MF: relationship: linked_to NeXO:9658 ! CC: | BP: regulation of ceramide biosynthetic process | MF: [Term] id: NeXO:5368 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.14924643795271 density:0.666666666666667 bootstrap:0.90382892 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6763 ! CC: | BP: | MF: [Term] id: NeXO:5369 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62982845 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5477 ! CC: | BP: | MF: [Term] id: NeXO:10019 name: CC: | BP: | MF:protein tag def: "CC_def: | BP_def: | MF_def:Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [NeXO-GO:term] namespace: NeXO comment: robustness:5.75307291578218 density:0.7 bootstrap:0.88344359 cc_score:0.0590158 bp_score:0.0517923 mf_score:0.173126 relationship: child_of NeXO:10034 ! CC: cell part | BP: cellular process | MF:binding relationship: linked_to NeXO:6783 ! CC: | BP: GO:0035965 | MF: relationship: linked_to NeXO:7712 ! CC: | BP: | MF: relationship: linked_to NeXO:9612 ! CC: | BP: GDP-mannose biosynthetic process | MF:mannose-1-phosphate guanylyltransferase activity relationship: linked_to NeXO:9604 ! CC: | BP: | MF: relationship: linked_to NeXO:9488 ! CC: | BP: | MF: relationship: linked_to NeXO:8634 ! CC: | BP: | MF: relationship: linked_to NeXO:9400 ! CC: | BP: glucose catabolic process to ethanol | MF:methylglyoxal reductase (NADH-dependent) activity relationship: linked_to NeXO:7350 ! CC: | BP: trehalose metabolic process | MF:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity relationship: linked_to NeXO:9413 ! CC: | BP: gluconeogenesis | MF:fructose-bisphosphate aldolase activity relationship: linked_to NeXO:9753 ! CC: | BP: | MF: relationship: linked_to NeXO:9660 ! CC: | BP: | MF: relationship: linked_to NeXO:6525 ! CC: | BP: ADP biosynthetic process | MF:dolichyl-phosphate beta-D-mannosyltransferase activity relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter relationship: linked_to NeXO:8939 ! CC: | BP: | MF: relationship: linked_to NeXO:9219 ! CC: | BP: | MF: [Term] id: NeXO:10013 name: CC: chromosome | BP: chromatin organization | MF:DNA binding def: "CC_def: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. | BP_def: Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. | MF_def:Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [NeXO-GO:term] namespace: NeXO comment: robustness:16.8165492914483 density:0.0396162178891984 bootstrap:0.3856691 cc_score:0.203026 bp_score:0.270262 mf_score:0.138619 relationship: child_of NeXO:10015 ! CC: nuclear part | BP: cellular component organization at cellular level | MF:regulation of transcription, DNA-dependent [Term] id: NeXO:10018 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.3129399384308 density:0.0515180366021369 bootstrap:0.174538821 cc_score:0.0517551 bp_score:0.0710898 mf_score:0.0565115 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:9238 name: CC: | BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) | MF: def: "CC_def: | BP_def: Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.2881738415589 density:1 bootstrap:0.27496081 cc_score:0.0 bp_score:0.438267 mf_score:0.0 relationship: child_of NeXO:9316 ! CC: | BP: | MF: relationship: linked_to NeXO:8912 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: [Term] id: NeXO:5588 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78549819 cc_score:0.0 bp_score:0.0 mf_score:0.0420934 relationship: child_of NeXO:5725 ! CC: | BP: | MF: [Term] id: NeXO:7354 name: CC: | BP: dTMP biosynthetic process | MF:thymidylate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). | MF_def:Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.18188350773004 density:1 bootstrap:0.78883281 cc_score:0.0 bp_score:0.440083 mf_score:0.438035 relationship: child_of NeXO:7442 ! CC: | BP: DNA ligation involved in DNA repair | MF:DNA ligase (ATP) activity [Term] id: NeXO:8254 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.20915656204478 density:0.2 bootstrap:0.589690402 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8800 ! CC: chaperonin-containing T-complex | BP: | MF: [Term] id: NeXO:8257 name: CC: | BP: | MF:Hsp90 protein binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [NeXO-GO:term] namespace: NeXO comment: robustness:1.29223933431274 density:0.333333333333333 bootstrap:0.33811542 cc_score:0.0 bp_score:0.0 mf_score:0.570429 relationship: child_of NeXO:8645 ! CC: | BP: regulation of stress-activated MAPK cascade | MF:Hsp70 protein binding relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:8256 name: CC: | BP: age-dependent response to oxidative stress involved in chronological cell aging | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.46987999205948 density:1 bootstrap:0.82626653 cc_score:0.0 bp_score:0.592336 mf_score:0.0502215 relationship: child_of NeXO:9138 ! CC: | BP: age-dependent response to oxidative stress | MF: [Term] id: NeXO:8250 name: CC: U2-type post-spliceosomal complex | BP: | MF: def: "CC_def: A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.568969372 cc_score:0.11266 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9399 ! CC: | BP: | MF: [Term] id: NeXO:8253 name: CC: | BP: mitochondrion degradation | MF:APG8 activating enzyme activity def: "CC_def: | BP_def: The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions. | MF_def:Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [NeXO-GO:term] namespace: NeXO comment: robustness:8.25532654288427 density:0.933333333333333 bootstrap:0.83326295 cc_score:0.0 bp_score:0.135904 mf_score:0.139807 relationship: child_of NeXO:9149 ! CC: autophagic vacuole membrane | BP: autophagic vacuole assembly | MF: [Term] id: NeXO:8252 name: CC: | BP: vacuolar protein processing | MF: def: "CC_def: | BP_def: Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.617220418 cc_score:0.0 bp_score:0.115003 mf_score:0.0 relationship: child_of NeXO:9149 ! CC: autophagic vacuole membrane | BP: autophagic vacuole assembly | MF: relationship: linked_to NeXO:8009 ! CC: pre-autophagosomal structure membrane | BP: protein homooligomerization | MF: [Term] id: NeXO:7636 name: CC: | BP: negative regulation of transcription by competitive promoter binding | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79425276307728 density:0.166666666666667 bootstrap:0.757628837 cc_score:0.0 bp_score:0.192887 mf_score:0.0 relationship: child_of NeXO:8248 ! CC: | BP: negative regulation of mitotic recombination | MF:NAD+ binding [Term] id: NeXO:9585 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.24459471479617 density:0.0512091038406828 bootstrap:0.132466025 cc_score:0.0 bp_score:0.0523419 mf_score:0.0250869 relationship: child_of NeXO:9783 ! CC: | BP: | MF: [Term] id: NeXO:8259 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.307890213 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9154 ! CC: | BP: | MF: relationship: linked_to NeXO:7922 ! CC: | BP: | MF: [Term] id: NeXO:8258 name: CC: | BP: | MF:cadmium ion transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.72621057605196 density:0.0952380952380952 bootstrap:0.441240809 cc_score:0.0 bp_score:0.0101987 mf_score:0.104119 relationship: child_of NeXO:8343 ! CC: | BP: | MF: [Term] id: NeXO:7880 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79058283 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8028 ! CC: | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding [Term] id: NeXO:5102 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81755615 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5179 ! CC: | BP: | MF: [Term] id: NeXO:8789 name: CC: transverse filament | BP: synaptonemal complex assembly | MF: def: "CC_def: A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. | BP_def: The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.35357750624275 density:0.607142857142857 bootstrap:0.470805593 cc_score:0.109016 bp_score:0.112208 mf_score:0.0 relationship: child_of NeXO:9021 ! CC: | BP: positive regulation of sister chromatid cohesion | MF: [Term] id: NeXO:6926 name: CC: | BP: ferrous iron transport | MF:ferrous iron transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.622947975 cc_score:0.0 bp_score:0.441044 mf_score:0.444063 relationship: child_of NeXO:7039 ! CC: | BP: low-affinity iron ion transport | MF:copper ion transmembrane transporter activity [Term] id: NeXO:8260 name: CC: nuclear microtubule | BP: spindle midzone assembly | MF: def: "CC_def: Any microtubule in the nucleus of a cell. | BP_def: The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71934358 cc_score:0.109913 bp_score:0.440151 mf_score:0.0 relationship: child_of NeXO:9118 ! CC: | BP: microtubule bundle formation | MF: relationship: linked_to NeXO:8841 ! CC: | BP: autophagic vacuole fusion | MF: relationship: linked_to NeXO:9836 ! CC: filamentous actin | BP: tubulin complex biogenesis | MF: [Term] id: NeXO:9235 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.75578257199846 density:1 bootstrap:0.41945761 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9314 ! CC: | BP: | MF: relationship: linked_to NeXO:9225 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:8783 name: CC: | BP: snRNP protein import into nucleus | MF: def: "CC_def: | BP_def: The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.14922455054886 density:0.666666666666667 bootstrap:0.420955827 cc_score:0.0 bp_score:0.276573 mf_score:0.0 relationship: child_of NeXO:9416 ! CC: | BP: ribosomal protein import into nucleus | MF:protein export from nucleus relationship: linked_to NeXO:8376 ! CC: Nup107-160 complex | BP: snRNA export from nucleus | MF: relationship: linked_to NeXO:9091 ! CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: relationship: linked_to NeXO:8641 ! CC: | BP: regulation of mRNA export from nucleus in response to heat stress | MF: [Term] id: NeXO:8782 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.88926261193535 density:1 bootstrap:0.591434299 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9518 ! CC: eukaryotic translation initiation factor 3 complex | BP: translation reinitiation | MF: relationship: linked_to NeXO:8689 ! CC: | BP: | MF: relationship: linked_to NeXO:9403 ! CC: eukaryotic translation initiation factor 2B complex | BP: regulation of translational initiation | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:8688 ! CC: multi-eIF complex | BP: mature ribosome assembly | MF: relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter [Term] id: NeXO:8781 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.314967101 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9466 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:8780 name: CC: Golgi transport complex | BP: intra-Golgi vesicle-mediated transport | MF: def: "CC_def: A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). | BP_def: The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.34512437885557 density:1 bootstrap:0.7890058 cc_score:0.439461 bp_score:0.137823 mf_score:0.0 relationship: child_of NeXO:9811 ! CC: | BP: | MF: relationship: linked_to NeXO:9183 ! CC: | BP: | MF: relationship: linked_to NeXO:9418 ! CC: | BP: inter-Golgi cisterna vesicle-mediated transport | MF: relationship: linked_to NeXO:9592 ! CC: peripheral to membrane of membrane fraction | BP: vesicle fusion with Golgi apparatus | MF:syntaxin binding relationship: linked_to NeXO:9222 ! CC: | BP: | MF: relationship: linked_to NeXO:9691 ! CC: | BP: | MF: [Term] id: NeXO:8787 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.00818954354923 density:0.4 bootstrap:0.48122193 cc_score:0.0 bp_score:0.0155837 mf_score:0.0 relationship: child_of NeXO:9499 ! CC: | BP: | MF: [Term] id: NeXO:9588 name: CC: | BP: actin cortical patch assembly | MF: def: "CC_def: | BP_def: Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.58098510021968 density:0.272727272727273 bootstrap:0.290329689 cc_score:0.0 bp_score:0.234213 mf_score:0.0 relationship: child_of NeXO:9758 ! CC: | BP: cortical actin cytoskeleton organization | MF: [Term] id: NeXO:8785 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.54348118856105 density:1 bootstrap:0.84865216 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9630 ! CC: Swr1 complex | BP: histone exchange | MF: relationship: linked_to NeXO:9010 ! CC: | BP: | MF: relationship: linked_to NeXO:9750 ! CC: | BP: negative regulation of meiosis | MF: [Term] id: NeXO:9589 name: CC: | BP: non-recombinational repair | MF:double-stranded telomeric DNA binding def: "CC_def: | BP_def: A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. | MF_def:Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:14.119989189336 density:0.725274725274725 bootstrap:0.574045661 cc_score:0.0 bp_score:0.126715 mf_score:0.170528 relationship: child_of NeXO:9715 ! CC: | BP: double-strand break repair via homologous recombination | MF:DNA metabolic process [Term] id: NeXO:7618 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.54582687728318 density:0.1 bootstrap:0.638381411 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8278 ! CC: | BP: | MF: [Term] id: NeXO:7614 name: CC: | BP: | MF:holocytochrome-c synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [NeXO-GO:term] namespace: NeXO comment: robustness:1.99553580720329 density:1 bootstrap:0.65984343 cc_score:0.0 bp_score:0.0 mf_score:0.295157 relationship: child_of NeXO:8544 ! CC: | BP: | MF: relationship: linked_to NeXO:7948 ! CC: | BP: | MF: [Term] id: NeXO:10017 name: CC: protein complex | BP: nucleic acid metabolic process | MF:GO:2001141 def: "CC_def: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. | BP_def: Any cellular metabolic process involving nucleic acids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.6116466120435 density:0.0098497906919478 bootstrap:0.291165152 cc_score:0.198921 bp_score:0.18861 mf_score:0.138653 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:7616 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.47932580848674 density:0.155555555555556 bootstrap:0.49021256 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8107 ! CC: | BP: | MF: [Term] id: NeXO:7617 name: CC: | BP: N-glycan processing | MF: def: "CC_def: | BP_def: The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.93055689375518 density:0.6 bootstrap:0.500435252 cc_score:0.0 bp_score:0.336765 mf_score:0.0 relationship: child_of NeXO:8374 ! CC: | BP: | MF: [Term] id: NeXO:7612 name: CC: | BP: very long-chain fatty acid metabolic process | MF:trans-2-enoyl-CoA reductase (NADPH) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater. | MF_def:Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.90754198026594 density:1 bootstrap:0.60293439 cc_score:0.0 bp_score:0.29245 mf_score:0.295368 relationship: child_of NeXO:8202 ! CC: | BP: | MF: [Term] id: NeXO:7613 name: CC: signal recognition particle, endoplasmic reticulum targeting | BP: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition | MF:7S RNA binding def: "CC_def: A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. | BP_def: The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. | MF_def:Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [NeXO-GO:term] namespace: NeXO comment: robustness:8.8768037090323 density:1 bootstrap:0.87041613 cc_score:0.750273 bp_score:0.758037 mf_score:0.625388 relationship: child_of NeXO:8270 ! CC: | BP: SRP-dependent cotranslational protein targeting to membrane | MF:signal sequence binding [Term] id: NeXO:8659 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.14959753134047 density:0.0285714285714286 bootstrap:0.215032177 cc_score:0.0 bp_score:0.0437692 mf_score:0.0608127 relationship: child_of NeXO:9473 ! CC: | BP: | MF: [Term] id: NeXO:8658 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.99782673569785 density:0.0434782608695652 bootstrap:0.348467929 cc_score:0.0 bp_score:0.0579837 mf_score:0.0 relationship: child_of NeXO:9477 ! CC: | BP: | MF: [Term] id: NeXO:9232 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.22920844273842 density:0.533333333333333 bootstrap:0.69180594 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9682 ! CC: | BP: | MF: [Term] id: NeXO:8651 name: CC: | BP: | MF:phosphatase activator activity def: "CC_def: | BP_def: | MF_def:Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:4.49246428536278 density:0.833333333333333 bootstrap:0.71100177 cc_score:0.0 bp_score:0.0958563 mf_score:0.252075 relationship: child_of NeXO:9437 ! CC: | BP: | MF:negative regulation of signal transduction relationship: linked_to NeXO:9497 ! CC: | BP: signal transduction involved in meiotic recombination checkpoint | MF:translation repressor activity, nucleic acid binding [Term] id: NeXO:8650 name: CC: condensed nuclear chromosome outer kinetochore | BP: establishment of meiotic sister chromatid cohesion | MF: def: "CC_def: The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. | BP_def: The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.66788467166392 density:1 bootstrap:0.8299271 cc_score:0.294087 bp_score:0.299992 mf_score:0.0 relationship: child_of NeXO:8930 ! CC: | BP: establishment of mitotic sister chromatid cohesion | MF: [Term] id: NeXO:7287 name: CC: cellular birth scar | BP: | MF: def: "CC_def: Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.618916 cc_score:0.440804 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8545 ! CC: | BP: | MF:sterol-transporting ATPase activity relationship: linked_to NeXO:9271 ! CC: | BP: | MF:tRNA-specific adenosine deaminase activity relationship: linked_to NeXO:6500 ! CC: | BP: | MF:structural constituent of cell wall [Term] id: NeXO:9233 name: CC: TRAPP complex | BP: | MF:Rab guanyl-nucleotide exchange factor activity def: "CC_def: A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion. Ras guanyl-nucleotide exchange factor activity has been demonstrated for this complex in S. cerevisiae. | BP_def: | MF_def:Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [NeXO-GO:term] namespace: NeXO comment: robustness:12.9129737984709 density:0.944444444444444 bootstrap:0.83889136 cc_score:0.623522 bp_score:0.0366269 mf_score:0.389594 relationship: child_of NeXO:9837 ! CC: cis-Golgi network | BP: Golgi to vacuole transport | MF:Ras guanyl-nucleotide exchange factor activity [Term] id: NeXO:8655 name: CC: | BP: | MF:bis(5'-nucleosyl)-tetraphosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [NeXO-GO:term] namespace: NeXO comment: robustness:1.63837367741389 density:0.333333333333333 bootstrap:0.286523877 cc_score:0.0 bp_score:0.0 mf_score:0.161793 relationship: child_of NeXO:9123 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:8654 name: CC: | BP: DNA dealkylation involved in DNA repair | MF:methylated-DNA-[protein]-cysteine S-methyltransferase activity def: "CC_def: | BP_def: The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT). | MF_def:Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.55382871 cc_score:0.0 bp_score:0.29186 mf_score:0.442985 relationship: child_of NeXO:9122 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: [Term] id: NeXO:8657 name: CC: | BP: | MF:cAMP-dependent protein kinase regulator activity def: "CC_def: | BP_def: | MF_def:Modulation of the activity of the enzyme cAMP-dependent protein kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:1.5545343459675 density:0.133333333333333 bootstrap:0.324947139 cc_score:0.0 bp_score:0.0243021 mf_score:0.147961 relationship: child_of NeXO:9006 ! CC: | BP: | MF:cAMP-dependent protein kinase activity [Term] id: NeXO:8656 name: CC: | BP: fructose import | MF:hexokinase activity def: "CC_def: | BP_def: The directed movement of the hexose monosaccharide fructose into a cell or organelle. | MF_def:Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.33939814772958 density:1 bootstrap:0.297263259 cc_score:0.0 bp_score:0.302675 mf_score:0.144994 relationship: child_of NeXO:9016 ! CC: | BP: cell cycle arrest in response to pheromone | MF: relationship: linked_to NeXO:8931 ! CC: | BP: | MF: [Term] id: NeXO:8431 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.331267294 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9226 ! CC: | BP: | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:5835 ! CC: | BP: | MF:L-serine ammonia-lyase activity [Term] id: NeXO:8433 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20086209225914 density:0.133333333333333 bootstrap:0.193909169 cc_score:0.0 bp_score:0.0361684 mf_score:0.0 relationship: child_of NeXO:8991 ! CC: | BP: | MF: [Term] id: NeXO:8432 name: CC: actin filament bundle | BP: actin filament depolymerization | MF:actin filament binding def: "CC_def: An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. | BP_def: Disassembly of actin filaments by the removal of actin monomers from a filament. | MF_def:Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [NeXO-GO:term] namespace: NeXO comment: robustness:3.09572390568676 density:0.190476190476190 bootstrap:0.619257763 cc_score:0.13721 bp_score:0.167482 mf_score:0.152364 relationship: child_of NeXO:9435 ! CC: | BP: actin polymerization or depolymerization | MF: [Term] id: NeXO:8435 name: CC: | BP: IMP biosynthetic process | MF:hydroxymethyl-, formyl- and related transferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. | MF_def:Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:11.1149003998408 density:0.928571428571429 bootstrap:0.81820152 cc_score:0.0 bp_score:0.400387 mf_score:0.113801 relationship: child_of NeXO:9252 ! CC: | BP: purine ribonucleoside monophosphate biosynthetic process | MF: [Term] id: NeXO:8434 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.39722637581368 density:0.466666666666667 bootstrap:0.57730188 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8572 ! CC: | BP: purine base biosynthetic process | MF: [Term] id: NeXO:8437 name: CC: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | BP: proton-transporting ATPase activity, rotational mechanism | MF:proton-transporting ATPase activity, rotational mechanism def: "CC_def: All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. | BP_def: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:4.53679212902193 density:0.163636363636364 bootstrap:0.646386208 cc_score:0.431983 bp_score:0.291706 mf_score:0.307908 relationship: child_of NeXO:8701 ! CC: mitochondrial proton-transporting ATP synthase complex | BP: ATP synthesis coupled proton transport | MF:hydrogen ion transporting ATP synthase activity, rotational mechanism [Term] id: NeXO:8436 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.52504740410174 density:0.5 bootstrap:0.421829397 cc_score:0.0 bp_score:0.0528186 mf_score:0.0 relationship: child_of NeXO:9198 ! CC: | BP: | MF: [Term] id: NeXO:8438 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.582928416 cc_score:0.0 bp_score:0.0294105 mf_score:0.0 relationship: child_of NeXO:8554 ! CC: MCM complex | BP: | MF: relationship: linked_to NeXO:8531 ! CC: | BP: DNA geometric change | MF: [Term] id: NeXO:9825 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.96022197398368 density:0.388888888888889 bootstrap:0.250993555 cc_score:0.0 bp_score:0.0712392 mf_score:0.0801674 relationship: child_of NeXO:9988 ! CC: DNA-directed RNA polymerase II, holoenzyme | BP: RNA polymerase II transcriptional preinitiation complex assembly | MF:RNA polymerase II transcriptional preinitiation complex assembly relationship: linked_to NeXO:9801 ! CC: SAGA-type complex | BP: internal peptidyl-lysine acetylation | MF:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity relationship: linked_to NeXO:9258 ! CC: SAGA complex | BP: protein deubiquitination | MF:histone acetylation [Term] id: NeXO:9824 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.04466587621628 density:0.0776942355889724 bootstrap:0.155327423 cc_score:0.0944427 bp_score:0.0726402 mf_score:0.0179132 relationship: child_of NeXO:9978 ! CC: | BP: | MF: [Term] id: NeXO:9827 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33953228001952 density:0.0215488215488215 bootstrap:0.122455464 cc_score:0.0 bp_score:0.0297512 mf_score:0.0 relationship: child_of NeXO:9947 ! CC: | BP: | MF: [Term] id: NeXO:5750 name: CC: | BP: copper ion export | MF:copper-exporting ATPase activity def: "CC_def: | BP_def: The directed movement of copper ions out of a cell or organelle. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.10472664440522 density:0.666666666666667 bootstrap:0.87845532 cc_score:0.0 bp_score:0.232265 mf_score:0.235212 relationship: child_of NeXO:6727 ! CC: | BP: copper ion transport | MF:sodium ion transmembrane transporter activity [Term] id: NeXO:6910 name: CC: | BP: NAD+ kinase activity | MF:NADH kinase activity def: "CC_def: | BP_def: Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). | MF_def:Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:1.91835253938565 density:0.333333333333333 bootstrap:0.74513662 cc_score:0.0 bp_score:0.160211 mf_score:0.160356 relationship: child_of NeXO:8218 ! CC: | BP: | MF: [Term] id: NeXO:6911 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.14949599581571 density:0.107142857142857 bootstrap:0.459478271 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7854 ! CC: | BP: | MF: [Term] id: NeXO:6912 name: CC: | BP: | MF:carbon-nitrogen ligase activity, with glutamine as amido-N-donor def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [NeXO-GO:term] namespace: NeXO comment: robustness:0.904638742714883 density:0.0357142857142857 bootstrap:0.299224964 cc_score:0.0 bp_score:0.0 mf_score:0.113694 relationship: child_of NeXO:8002 ! CC: | BP: | MF: [Term] id: NeXO:9822 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.6020427943337 density:0.571428571428571 bootstrap:0.45924552 cc_score:0.0 bp_score:0.0431687 mf_score:0.055025 relationship: child_of NeXO:9913 ! CC: | BP: | MF: [Term] id: NeXO:5969 name: CC: | BP: meiotic sister chromatid cohesion involved in meiosis I | MF: def: "CC_def: | BP_def: The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90106813 cc_score:0.0 bp_score:0.441024 mf_score:0.0 relationship: child_of NeXO:6206 ! CC: | BP: | MF: [Term] id: NeXO:5759 name: CC: | BP: | MF:mannitol dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:2.05030952797173 density:0.333333333333333 bootstrap:0.851173168 cc_score:0.0 bp_score:0.0 mf_score:0.317648 relationship: child_of NeXO:6048 ! CC: | BP: cellular response to arsenic-containing substance | MF:hexitol dehydrogenase activity [Term] id: NeXO:5199 name: CC: | BP: nicotinamide metabolic process | MF:nicotinamide N-methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83776972 cc_score:0.0 bp_score:0.313554 mf_score:0.313569 relationship: child_of NeXO:5406 ! CC: | BP: | MF:dodecenoyl-CoA delta-isomerase activity [Term] id: NeXO:6918 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.01348998646411 density:0.5 bootstrap:0.653315071 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7416 ! CC: | BP: | MF: [Term] id: NeXO:6919 name: CC: | BP: clathrin coat assembly | MF: def: "CC_def: | BP_def: The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86015412 cc_score:0.0 bp_score:0.882734 mf_score:0.0 relationship: child_of NeXO:8075 ! CC: | BP: vesicle coating | MF:clathrin binding relationship: linked_to NeXO:8034 ! CC: | BP: regulation of endocytosis | MF: [Term] id: NeXO:6449 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84665156 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7620 ! CC: | BP: | MF: [Term] id: NeXO:5591 name: CC: | BP: phosphatidylethanolamine biosynthetic process | MF:ethanolamine-phosphate cytidylyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. | MF_def:Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90237297 cc_score:0.0 bp_score:0.177286 mf_score:0.446758 relationship: child_of NeXO:6157 ! CC: | BP: | MF:3-methylbutanol:NAD(P) oxidoreductase activity [Term] id: NeXO:8865 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.49314877192926 density:0.333333333333333 bootstrap:0.451424606 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9230 ! CC: | BP: | MF: relationship: linked_to NeXO:9327 ! CC: | BP: positive regulation of lipid biosynthetic process | MF: [Term] id: NeXO:5593 name: CC: GINS complex | BP: | MF: def: "CC_def: A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2285847131165 density:1 bootstrap:0.82296268 cc_score:0.442103 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7771 ! CC: | BP: | MF: [Term] id: NeXO:5592 name: CC: | BP: farnesyl diphosphate biosynthetic process | MF:geranyltranstransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. | MF_def:Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.863710928 cc_score:0.0 bp_score:0.183973 mf_score:0.294509 relationship: child_of NeXO:6749 ! CC: | BP: | MF: [Term] id: NeXO:5595 name: CC: | BP: | MF:imidazoleglycerol-phosphate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78178669 cc_score:0.0 bp_score:0.0 mf_score:0.443547 relationship: child_of NeXO:5697 ! CC: | BP: histidine biosynthetic process | MF:ATP phosphoribosyltransferase activity [Term] id: NeXO:5597 name: CC: | BP: | MF:nicotinate-nucleotide adenylyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.8801929763304 density:0.3 bootstrap:0.622308833 cc_score:0.0 bp_score:0.086067 mf_score:0.166824 relationship: child_of NeXO:6269 ! CC: | BP: | MF: [Term] id: NeXO:5596 name: CC: | BP: | MF:3-deoxy-7-phosphoheptulonate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.06921019811759 density:1 bootstrap:0.70946515 cc_score:0.0 bp_score:0.0369761 mf_score:0.877466 relationship: child_of NeXO:5597 ! CC: | BP: | MF:nicotinate-nucleotide adenylyltransferase activity [Term] id: NeXO:5599 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3333554342339 density:1 bootstrap:0.90216016 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7082 ! CC: site of double-strand break | BP: | MF: [Term] id: NeXO:5598 name: CC: | BP: L-phenylalanine biosynthetic process | MF:prephenate dehydratase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. | MF_def:Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.519759604 cc_score:0.0 bp_score:0.443779 mf_score:0.43919 relationship: child_of NeXO:5739 ! CC: | BP: aromatic amino acid family biosynthetic process, prephenate pathway | MF: [Term] id: NeXO:9316 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89609033651259 density:0.666666666666667 bootstrap:0.327635528 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9670 ! CC: | BP: | MF: relationship: linked_to NeXO:9224 ! CC: | BP: | MF: relationship: linked_to NeXO:9615 ! CC: | BP: | MF: [Term] id: NeXO:9829 name: CC: U4/U6 x U5 tri-snRNP complex | BP: | MF: def: "CC_def: A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.7646182899549 density:0.93939393939394 bootstrap:0.451650586 cc_score:0.26005 bp_score:0.0414141 mf_score:0.0 relationship: child_of NeXO:9939 ! CC: cytoplasmic mRNA processing body | BP: mRNA catabolic process | MF: [Term] id: NeXO:7729 name: CC: | BP: snoRNA polyadenylation | MF:ATP-dependent 3'-5' RNA helicase activity def: "CC_def: | BP_def: The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'." [NeXO-GO:term] namespace: NeXO comment: robustness:2.79643991714276 density:0.666666666666667 bootstrap:0.71266253 cc_score:0.0 bp_score:0.180184 mf_score:0.313505 relationship: child_of NeXO:8388 ! CC: TRAMP complex | BP: ncRNA polyadenylation | MF:polynucleotide adenylyltransferase activity [Term] id: NeXO:6845 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17462308247455 density:0.0952380952380952 bootstrap:0.70025483 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7080 ! CC: | BP: | MF: [Term] id: NeXO:7285 name: CC: intermediate layer of spindle pole body | BP: | MF: def: "CC_def: Structure between the central and outer plaques of the spindle pole body. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.0705273796057 density:1 bootstrap:0.91516529 cc_score:0.298511 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7747 ! CC: | BP: mitotic anaphase | MF: [Term] id: NeXO:7720 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02470831246138 density:0.333333333333333 bootstrap:0.437582381 cc_score:0.0 bp_score:0.0427067 mf_score:0.0 relationship: child_of NeXO:8751 ! CC: | BP: | MF: [Term] id: NeXO:7722 name: CC: | BP: sterol import | MF:histone-arginine N-methyltransferase activity def: "CC_def: | BP_def: The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.541760606 cc_score:0.0 bp_score:0.18028 mf_score:0.271967 relationship: child_of NeXO:8873 ! CC: | BP: | MF:protein-arginine omega-N monomethyltransferase activity [Term] id: NeXO:7723 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.52625817379734 density:0.0769230769230769 bootstrap:0.288357814 cc_score:0.0 bp_score:0.0514656 mf_score:0.0814071 relationship: child_of NeXO:8705 ! CC: | BP: | MF: [Term] id: NeXO:7724 name: CC: anthranilate synthase complex | BP: tryptophan biosynthetic process | MF:tryptophan biosynthetic process def: "CC_def: A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine. | BP_def: The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. | MF_def:The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [NeXO-GO:term] namespace: NeXO comment: robustness:5.69111115014817 density:1 bootstrap:0.89445542 cc_score:0.437556 bp_score:0.703208 mf_score:0.683333 relationship: child_of NeXO:8523 ! CC: | BP: tryptophan metabolic process | MF:anthranilate synthase activity [Term] id: NeXO:7725 name: CC: SMC loading complex | BP: meiotic chromosome condensation | MF: def: "CC_def: A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved. | BP_def: Compaction of chromatin structure prior to meiosis in eukaryotic cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.27785563347076 density:1 bootstrap:0.769271385 cc_score:0.291823 bp_score:0.447797 mf_score:0.0 relationship: child_of NeXO:8082 ! CC: nuclear condensin complex | BP: tRNA gene clustering | MF: [Term] id: NeXO:7726 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.59288596 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8861 ! CC: | BP: | MF: [Term] id: NeXO:7727 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.207621575 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8238 ! CC: | BP: | MF: [Term] id: NeXO:8040 name: CC: | BP: polyol metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90831134172072 density:0.0952380952380952 bootstrap:0.286088492 cc_score:0.0 bp_score:0.135663 mf_score:0.0811431 relationship: child_of NeXO:8809 ! CC: | BP: | MF: [Term] id: NeXO:6474 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.95184117714999 density:1 bootstrap:0.86257555 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7420 ! CC: clathrin coat of trans-Golgi network vesicle | BP: | MF: [Term] id: NeXO:7213 name: CC: | BP: D-xylose metabolic process | MF:sugar-phosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. | MF_def:Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35391236077533 density:0.142857142857143 bootstrap:0.388583357 cc_score:0.0 bp_score:0.133161 mf_score:0.139532 relationship: child_of NeXO:8394 ! CC: | BP: | MF: [Term] id: NeXO:6722 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84171571 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7662 ! CC: | BP: | MF: [Term] id: NeXO:10016 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.2842749907133 density:0.0670586837728677 bootstrap:0.361641224 cc_score:0.0311314 bp_score:0.0448082 mf_score:0.0309523 relationship: child_of NeXO:10017 ! CC: protein complex | BP: nucleic acid metabolic process | MF:GO:2001141 [Term] id: NeXO:8517 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.25367585632533 density:0.166666666666667 bootstrap:0.369879084 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9361 ! CC: | BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:8042 name: CC: nucleolar chromatin | BP: negative regulation of histone H3-K14 acetylation | MF:triplex DNA binding def: "CC_def: The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone. | MF_def:Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.745424496 cc_score:0.21899 bp_score:0.294178 mf_score:0.292868 relationship: child_of NeXO:9175 ! CC: transcriptionally active chromatin | BP: GO:2001209 | MF: [Term] id: NeXO:9828 name: CC: organelle inner membrane | BP: establishment of protein localization in mitochondrion | MF:channel activity def: "CC_def: The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. | BP_def: The directed movement of a protein to a specific location in the mitochondrion. | MF_def:Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [NeXO-GO:term] namespace: NeXO comment: robustness:12.1259443348819 density:0.121915820029028 bootstrap:0.288436978 cc_score:0.10171 bp_score:0.194559 mf_score:0.102409 relationship: child_of NeXO:9958 ! CC: mitochondrial membrane part | BP: mitochondrion organization | MF: [Term] id: NeXO:6709 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.59686354011224 density:0.333333333333333 bootstrap:0.51631492 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7932 ! CC: | BP: | MF: [Term] id: NeXO:6708 name: CC: | BP: snoRNA processing | MF:urea transmembrane transporter activity def: "CC_def: | BP_def: Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA. | MF_def:Enables the directed movement of urea cross a membrane into, out of or within a cell, or between cells. Urea is the water soluble compound H2N-CO-NH2." [NeXO-GO:term] namespace: NeXO comment: robustness:10.3128007334932 density:0.515151515151515 bootstrap:0.65695066 cc_score:0.0687355 bp_score:0.154421 mf_score:0.125323 relationship: child_of NeXO:8362 ! CC: | BP: snoRNA metabolic process | MF: [Term] id: NeXO:8043 name: CC: polar microtubule | BP: response to antibiotic | MF: def: "CC_def: Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35229652783284 density:1 bootstrap:0.91686624 cc_score:0.586053 bp_score:0.125184 mf_score:0.0 relationship: child_of NeXO:8984 ! CC: tubulin complex | BP: nuclear migration involved in conjugation with cellular fusion | MF: [Term] id: NeXO:8329 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.32183465943612 density:0.158333333333333 bootstrap:0.43718371 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8906 ! CC: | BP: | MF: [Term] id: NeXO:8328 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.02084134438492 density:0.6 bootstrap:0.295593959 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8355 ! CC: | BP: | MF: [Term] id: NeXO:6454 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88669109 cc_score:0.0 bp_score:0.0888952 mf_score:0.0 relationship: child_of NeXO:8016 ! CC: | BP: | MF: [Term] id: NeXO:8325 name: CC: | BP: regulation of ion transport | MF:voltage-gated ion channel activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:2.29712277912479 density:0.178571428571429 bootstrap:0.281793033 cc_score:0.0 bp_score:0.114731 mf_score:0.114547 relationship: child_of NeXO:9134 ! CC: | BP: protein modification by small protein removal | MF: [Term] id: NeXO:8324 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15320078747658 density:0.333333333333333 bootstrap:0.494884618 cc_score:0.0 bp_score:0.0104223 mf_score:0.0 relationship: child_of NeXO:8649 ! CC: | BP: | MF: relationship: linked_to NeXO:8590 ! CC: Ndc80 complex | BP: | MF: [Term] id: NeXO:6703 name: CC: signal peptidase complex | BP: signal peptide processing | MF: def: "CC_def: A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. | BP_def: The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79579466 cc_score:0.337626 bp_score:0.211888 mf_score:0.0 relationship: child_of NeXO:7949 ! CC: | BP: | MF: [Term] id: NeXO:8326 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.177530914 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9276 ! CC: | BP: | MF: [Term] id: NeXO:6705 name: CC: ribonuclease P complex | BP: box C/D snoRNA processing | MF:tRNA-specific ribonuclease activity def: "CC_def: A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. | BP_def: Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA. | MF_def:Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [NeXO-GO:term] namespace: NeXO comment: robustness:9.17114460359471 density:0.577777777777778 bootstrap:0.65484385 cc_score:0.446344 bp_score:0.457804 mf_score:0.356644 relationship: child_of NeXO:6706 ! CC: ribonuclease MRP complex | BP: mRNA cleavage | MF:ribonuclease MRP activity [Term] id: NeXO:6704 name: CC: nucleolar ribonuclease P complex | BP: intronic box C/D snoRNA processing | MF:ribonuclease P activity def: "CC_def: A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. | BP_def: Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA. | MF_def:Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [NeXO-GO:term] namespace: NeXO comment: robustness:10.1628994513118 density:0.722222222222222 bootstrap:0.75066507 cc_score:0.580218 bp_score:0.580769 mf_score:0.489253 relationship: child_of NeXO:6705 ! CC: ribonuclease P complex | BP: box C/D snoRNA processing | MF:tRNA-specific ribonuclease activity [Term] id: NeXO:8323 name: CC: condensed nuclear chromosome inner kinetochore | BP: | MF: def: "CC_def: The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.706542583 cc_score:0.441027 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8929 ! CC: | BP: | MF: relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter [Term] id: NeXO:8513 name: CC: | BP: GO:2001043 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06533264990263 density:1 bootstrap:0.70680867 cc_score:0.0 bp_score:0.445655 mf_score:0.0 relationship: child_of NeXO:8948 ! CC: | BP: cytokinetic cell separation involved in cell cycle cytokinesis | MF: [Term] id: NeXO:9911 name: CC: nuclear DNA-directed RNA polymerase complex | BP: transcription from RNA polymerase III promoter | MF:DNA-directed RNA polymerase activity def: "CC_def: A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. | BP_def: The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. | MF_def:Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [NeXO-GO:term] namespace: NeXO comment: robustness:23.8396910947817 density:0.679653679653680 bootstrap:0.77507249 cc_score:0.563418 bp_score:0.245787 mf_score:0.490953 relationship: child_of NeXO:9915 ! CC: DNA-directed RNA polymerase complex | BP: polyadenylation-dependent mRNA catabolic process | MF:nucleotidyltransferase activity [Term] id: NeXO:9910 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.19579587620568 density:0.132307692307692 bootstrap:0.129511182 cc_score:0.0 bp_score:0.0829369 mf_score:0.0312171 relationship: child_of NeXO:9934 ! CC: | BP: | MF: [Term] id: NeXO:9913 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.164881642625 density:0.235729386892178 bootstrap:0.313631103 cc_score:0.0 bp_score:0.0781708 mf_score:0.0 relationship: child_of NeXO:9993 ! CC: actin cytoskeleton | BP: | MF: [Term] id: NeXO:9912 name: CC: | BP: protein desumoylation | MF: def: "CC_def: | BP_def: The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.95526015619736 density:0.340659340659341 bootstrap:0.270113741 cc_score:0.0304865 bp_score:0.143571 mf_score:0.0 relationship: child_of NeXO:10014 ! CC: | BP: positive regulation of transcription elongation, DNA-dependent | MF: [Term] id: NeXO:10015 name: CC: nuclear part | BP: cellular component organization at cellular level | MF:regulation of transcription, DNA-dependent def: "CC_def: Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. | BP_def: A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. | MF_def:Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [NeXO-GO:term] namespace: NeXO comment: robustness:11.6632714829836 density:0.0112453616169378 bootstrap:0.185516202 cc_score:0.16948 bp_score:0.174269 mf_score:0.119534 relationship: child_of NeXO:10017 ! CC: protein complex | BP: nucleic acid metabolic process | MF:GO:2001141 [Term] id: NeXO:6095 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.92442850765342 density:0.666666666666667 bootstrap:0.77939023 cc_score:0.0 bp_score:0.0 mf_score:0.0896247 relationship: child_of NeXO:6442 ! CC: | BP: dITP catabolic process | MF:dITP diphosphatase activity [Term] id: NeXO:9917 name: CC: | BP: G-protein coupled receptor protein signaling pathway | MF: def: "CC_def: | BP_def: The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.0159458088461 density:0.174358974358974 bootstrap:0.174832134 cc_score:0.0634678 bp_score:0.111856 mf_score:0.0840604 relationship: child_of NeXO:9931 ! CC: | BP: regulation of protein kinase activity | MF: [Term] id: NeXO:9916 name: CC: polysomal ribosome | BP: | MF: def: "CC_def: A ribosome bound to mRNA that forms part of a polysome. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.32362748530594 density:0.333333333333333 bootstrap:0.187010697 cc_score:0.135037 bp_score:0.0906446 mf_score:0.0430524 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity relationship: linked_to NeXO:9615 ! CC: | BP: | MF: relationship: linked_to NeXO:8946 ! CC: | BP: snRNA pseudouridine synthesis | MF: [Term] id: NeXO:9919 name: CC: condensed chromosome kinetochore | BP: sister chromatid segregation | MF: def: "CC_def: A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules. | BP_def: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.2545929965444 density:0.184012066365008 bootstrap:0.317352793 cc_score:0.260444 bp_score:0.18704 mf_score:0.0 relationship: child_of NeXO:9980 ! CC: microtubule cytoskeleton | BP: microtubule-based process | MF: [Term] id: NeXO:9918 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.5355343492173 density:0.0865302642796249 bootstrap:0.336997284 cc_score:0.0979416 bp_score:0.0891051 mf_score:0.0 relationship: child_of NeXO:9929 ! CC: | BP: | MF: [Term] id: NeXO:8511 name: CC: | BP: negative regulation of antisense RNA transcription | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15517758983471 density:1 bootstrap:0.769640604 cc_score:0.0 bp_score:0.443544 mf_score:0.0 relationship: child_of NeXO:9546 ! CC: | BP: antisense RNA metabolic process | MF:DNA topoisomerase activity [Term] id: NeXO:7434 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.431178568 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8072 ! CC: | BP: | MF: [Term] id: NeXO:7435 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.81723608134809 density:0.3 bootstrap:0.59540061 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7436 ! CC: | BP: vitamin B6 biosynthetic process | MF: [Term] id: NeXO:7436 name: CC: | BP: vitamin B6 biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.68923596952514 density:0.218181818181818 bootstrap:0.481050369 cc_score:0.0 bp_score:0.225974 mf_score:0.0 relationship: child_of NeXO:8602 ! CC: | BP: thiamine metabolic process | MF: [Term] id: NeXO:7437 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.47989217667353 density:1 bootstrap:0.82929413 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8750 ! CC: | BP: | MF: [Term] id: NeXO:5689 name: CC: i-AAA complex | BP: | MF:misfolded protein binding def: "CC_def: Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. | BP_def: | MF_def:Interacting selectively and non-covalently with a misfolded protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.30686754277634 density:1 bootstrap:0.88179405 cc_score:0.583898 bp_score:0.0 mf_score:0.583537 relationship: child_of NeXO:5704 ! CC: | BP: | MF: [Term] id: NeXO:5688 name: CC: | BP: lactate metabolic process | MF:L-lactate dehydrogenase (cytochrome) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving lactate, the anion of lactic acid. | MF_def:Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75715334 cc_score:0.0 bp_score:0.132726 mf_score:0.441789 relationship: child_of NeXO:6830 ! CC: | BP: | MF: [Term] id: NeXO:7432 name: CC: | BP: NADH oxidation | MF: def: "CC_def: | BP_def: A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28167838437038 density:0.4 bootstrap:0.276849582 cc_score:0.0 bp_score:0.20716 mf_score:0.0 relationship: child_of NeXO:8443 ! CC: | BP: fermentation | MF: [Term] id: NeXO:5365 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.47284382128631 density:1 bootstrap:0.82716219 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5366 ! CC: | BP: | MF: [Term] id: NeXO:5685 name: CC: | BP: protein localization to pre-autophagosomal structure | MF: def: "CC_def: | BP_def: Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2460941133606 density:1 bootstrap:0.83594508 cc_score:0.0 bp_score:0.350547 mf_score:0.0 relationship: child_of NeXO:5714 ! CC: | BP: | MF: [Term] id: NeXO:5684 name: CC: | BP: ferrochelatase activity | MF:uroporphyrinogen decarboxylase activity def: "CC_def: | BP_def: Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. | MF_def:Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89778007 cc_score:0.0 bp_score:0.291667 mf_score:0.439517 relationship: child_of NeXO:6590 ! CC: | BP: | MF:ferrochelatase activity [Term] id: NeXO:5686 name: CC: | BP: meiotic DNA double-strand break formation | MF: def: "CC_def: | BP_def: The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35309189089106 density:1 bootstrap:0.91748637 cc_score:0.0 bp_score:0.175572 mf_score:0.0 relationship: child_of NeXO:6477 ! CC: | BP: | MF: [Term] id: NeXO:7438 name: CC: cis-Golgi network membrane | BP: | MF: def: "CC_def: The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.3213808536324 density:0.952380952380952 bootstrap:0.905379424 cc_score:0.186104 bp_score:0.0534911 mf_score:0.0 relationship: child_of NeXO:9233 ! CC: TRAPP complex | BP: | MF:Rab guanyl-nucleotide exchange factor activity [Term] id: NeXO:7439 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.94205002911356 density:0.0718954248366013 bootstrap:0.296082928 cc_score:0.0 bp_score:0.0202945 mf_score:0.0299306 relationship: child_of NeXO:8562 ! CC: | BP: | MF: [Term] id: NeXO:5683 name: CC: nuclear outer membrane | BP: heme oxidation | MF:heme oxygenase (decyclizing) activity def: "CC_def: The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. | BP_def: The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. | MF_def:Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90859457 cc_score:0.143437 bp_score:0.438455 mf_score:0.439218 relationship: child_of NeXO:6198 ! CC: | BP: heme catabolic process | MF: [Term] id: NeXO:5682 name: CC: | BP: mRNA methylation | MF:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity def: "CC_def: | BP_def: The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84877384 cc_score:0.0 bp_score:0.437969 mf_score:0.451497 relationship: child_of NeXO:6585 ! CC: | BP: | MF:mRNA (N6-adenosine)-methyltransferase activity [Term] id: NeXO:10014 name: CC: | BP: positive regulation of transcription elongation, DNA-dependent | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.4361606559436 density:0.153508771929825 bootstrap:0.148532875 cc_score:0.0331012 bp_score:0.115916 mf_score:0.0748736 relationship: child_of NeXO:10018 ! CC: | BP: | MF: [Term] id: NeXO:9866 name: CC: | BP: mitotic cell cycle G2/M transition checkpoint | MF: def: "CC_def: | BP_def: A mitotic cell cycle checkpoint that blocks entry into M phase. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.9674662060047 density:0.617647058823529 bootstrap:0.341513965 cc_score:0.0868566 bp_score:0.162797 mf_score:0.0 relationship: child_of NeXO:9980 ! CC: microtubule cytoskeleton | BP: microtubule-based process | MF: [Term] id: NeXO:6062 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.010529103198 density:0.333333333333333 bootstrap:0.818464398 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7029 ! CC: | BP: | MF: [Term] id: NeXO:6675 name: CC: | BP: | MF:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:1.61224629949939 density:0.166666666666667 bootstrap:0.61171908 cc_score:0.0 bp_score:0.0135602 mf_score:0.2649 relationship: child_of NeXO:7823 ! CC: | BP: lysine biosynthetic process via aminoadipic acid | MF:saccharopine dehydrogenase activity [Term] id: NeXO:6677 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.84120268953776 density:0.4 bootstrap:0.78463823 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6678 ! CC: | BP: | MF: [Term] id: NeXO:6676 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.57933209012576 density:0.3 bootstrap:0.499088214 cc_score:0.0 bp_score:0.0404526 mf_score:0.0614714 relationship: child_of NeXO:7629 ! CC: | BP: | MF: [Term] id: NeXO:6671 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.13997168458052 density:0.151515151515152 bootstrap:0.286623782 cc_score:0.0 bp_score:0.0615349 mf_score:0.0746346 relationship: child_of NeXO:7964 ! CC: | BP: | MF: [Term] id: NeXO:6670 name: CC: | BP: tRNA 3'-trailer cleavage, endonucleolytic | MF:glucose-6-phosphate 1-epimerase activity def: "CC_def: | BP_def: Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. | MF_def:Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.70651048024552 density:1 bootstrap:0.75880231 cc_score:0.0 bp_score:0.296171 mf_score:0.295579 relationship: child_of NeXO:6671 ! CC: | BP: | MF: [Term] id: NeXO:6673 name: CC: | BP: regulation of glycolysis | MF:phosphofructokinase activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of glycolysis. | MF_def:Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.76201270107577 density:0.333333333333333 bootstrap:0.62863294 cc_score:0.0 bp_score:0.223757 mf_score:0.234212 relationship: child_of NeXO:6877 ! CC: | BP: | MF: [Term] id: NeXO:6672 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.816346439 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6996 ! CC: | BP: | MF:acetyl-CoA carboxylase activity [Term] id: NeXO:6679 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.61630437765617 density:0.1 bootstrap:0.69791868 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7540 ! CC: | BP: | MF: [Term] id: NeXO:6678 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.94813396691147 density:0.109090909090909 bootstrap:0.454370942 cc_score:0.0 bp_score:0.036597 mf_score:0.0 relationship: child_of NeXO:7387 ! CC: | BP: | MF: [Term] id: NeXO:7970 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83769013 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8781 ! CC: | BP: | MF: [Term] id: NeXO:8286 name: CC: | BP: glycerophospholipid catabolic process | MF:glycerophosphodiester phosphodiesterase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. | MF_def:Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.28364723 cc_score:0.0 bp_score:0.134264 mf_score:0.202667 relationship: child_of NeXO:9189 ! CC: | BP: | MF: [Term] id: NeXO:9842 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.48955005573279 density:0.0994152046783626 bootstrap:0.124288052 cc_score:0.0 bp_score:0.0432173 mf_score:0.0407018 relationship: child_of NeXO:9948 ! CC: | BP: response to osmotic stress | MF: [Term] id: NeXO:8284 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.489149962 cc_score:0.0162568 bp_score:0.0830424 mf_score:0.0 relationship: child_of NeXO:8631 ! CC: extrachromosomal circular DNA | BP: 2-micrometer plasmid partitioning | MF: [Term] id: NeXO:5979 name: CC: | BP: dicarboxylic acid transport | MF: def: "CC_def: | BP_def: The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16308481042075 density:1 bootstrap:0.775298497 cc_score:0.0 bp_score:0.123723 mf_score:0.0374712 relationship: child_of NeXO:6199 ! CC: | BP: | MF: [Term] id: NeXO:5978 name: CC: | BP: regulation of ion transmembrane transport | MF:potassium channel activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. | MF_def:Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.593838729 cc_score:0.0 bp_score:0.221125 mf_score:0.228149 relationship: child_of NeXO:6837 ! CC: | BP: potassium ion transmembrane transport | MF:potassium ion transmembrane transporter activity [Term] id: NeXO:5973 name: CC: CURI complex | BP: | MF: def: "CC_def: A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86598308 cc_score:0.35011 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6924 ! CC: | BP: snoRNA localization | MF: [Term] id: NeXO:5674 name: CC: | BP: isoleucine biosynthetic process | MF:homoserine dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. | MF_def:Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93741105 cc_score:0.0 bp_score:0.185072 mf_score:0.438098 relationship: child_of NeXO:6545 ! CC: | BP: homoserine biosynthetic process | MF:aspartate-semialdehyde dehydrogenase activity relationship: linked_to NeXO:7810 ! CC: | BP: L-serine biosynthetic process | MF:aspartate kinase activity [Term] id: NeXO:5971 name: CC: trans-Golgi network transport vesicle membrane | BP: | MF: def: "CC_def: The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03769386933814 density:0.333333333333333 bootstrap:0.84073077 cc_score:0.163155 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6942 ! CC: clathrin adaptor complex | BP: | MF: [Term] id: NeXO:5970 name: CC: AP-1 adaptor complex | BP: | MF: def: "CC_def: A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88230264 cc_score:0.296467 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5971 ! CC: trans-Golgi network transport vesicle membrane | BP: | MF: [Term] id: NeXO:5977 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.00122054019537 density:0.666666666666667 bootstrap:0.82085937 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6000 ! CC: | BP: | MF: [Term] id: NeXO:5976 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.849032687 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5977 ! CC: | BP: | MF: [Term] id: NeXO:9864 name: CC: DNA helicase complex | BP: vesicle transport along actin filament | MF:3'-5' DNA helicase activity def: "CC_def: A protein complex that possesses DNA helicase activity. | BP_def: Movement of a vesicle along an actin filament, mediated by motor proteins. | MF_def:Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [NeXO-GO:term] namespace: NeXO comment: robustness:4.21867093697343 density:1 bootstrap:0.294891525 cc_score:0.299974 bp_score:0.167607 mf_score:0.246032 relationship: child_of NeXO:9967 ! CC: nuclear chromatin | BP: | MF: relationship: linked_to NeXO:8093 ! CC: Ino80 complex | BP: | MF:DNA end binding relationship: linked_to NeXO:9806 ! CC: | BP: | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:8915 ! CC: | BP: | MF:histone acetyltransferase activity relationship: linked_to NeXO:9630 ! CC: Swr1 complex | BP: histone exchange | MF: relationship: linked_to NeXO:7886 ! CC: | BP: | MF: [Term] id: NeXO:5675 name: CC: | BP: oxygen transport | MF:phosphatidate cytidylyltransferase activity def: "CC_def: | BP_def: The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.799009521 cc_score:0.0 bp_score:0.291712 mf_score:0.446757 relationship: child_of NeXO:6534 ! CC: | BP: phosphatidylglycerol biosynthetic process | MF:short-chain carboxylesterase activity relationship: linked_to NeXO:9571 ! CC: | BP: DNA damage induced protein phosphorylation | MF:histone phosphorylation [Term] id: NeXO:5676 name: CC: | BP: tRNA pseudouridine synthesis | MF: def: "CC_def: | BP_def: The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80609647 cc_score:0.0 bp_score:0.110243 mf_score:0.0 relationship: child_of NeXO:6852 ! CC: | BP: positive regulation of ligase activity | MF: [Term] id: NeXO:8281 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.40652155802283 density:1 bootstrap:0.32780429 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8478 ! CC: | BP: | MF:phosphatidylinositol-3,5-bisphosphate binding relationship: linked_to NeXO:7420 ! CC: clathrin coat of trans-Golgi network vesicle | BP: | MF: [Term] id: NeXO:8695 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73490951330593 density:0.6 bootstrap:0.45185583 cc_score:0.0 bp_score:0.0978288 mf_score:0.0 relationship: child_of NeXO:9223 ! CC: | BP: | MF: [Term] id: NeXO:5770 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87280676121364 density:0.333333333333333 bootstrap:0.710174382 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6552 ! CC: | BP: | MF: [Term] id: NeXO:9145 name: CC: | BP: dicarboxylic acid metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.46908862576893 density:0.184210526315789 bootstrap:0.339032648 cc_score:0.0 bp_score:0.147614 mf_score:0.0627696 relationship: child_of NeXO:9771 ! CC: | BP: | MF: [Term] id: NeXO:6938 name: CC: | BP: N-terminal peptidyl-glycine N-myristoylation | MF:glycylpeptide N-tetradecanoyltransferase activity def: "CC_def: | BP_def: The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. | MF_def:Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [NeXO-GO:term] namespace: NeXO comment: robustness:1.86319389794695 density:0.333333333333333 bootstrap:0.37055357 cc_score:0.0 bp_score:0.251436 mf_score:0.250822 relationship: child_of NeXO:7341 ! CC: | BP: | MF:medium-chain fatty acid-CoA ligase activity [Term] id: NeXO:5902 name: CC: | BP: sodium ion transport | MF:sodium-exporting ATPase activity, phosphorylative mechanism def: "CC_def: | BP_def: The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [NeXO-GO:term] namespace: NeXO comment: robustness:2.62492874973595 density:0.333333333333333 bootstrap:0.73547842 cc_score:0.0 bp_score:0.196482 mf_score:0.331119 relationship: child_of NeXO:5984 ! CC: | BP: | MF:superoxide dismutase activity [Term] id: NeXO:5296 name: CC: | BP: protein oligomerization | MF: def: "CC_def: | BP_def: The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.78387800912445 density:0.166666666666667 bootstrap:0.748892623 cc_score:0.0 bp_score:0.122198 mf_score:0.0 relationship: child_of NeXO:5492 ! CC: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) | BP: | MF: [Term] id: NeXO:9848 name: CC: H4/H2A histone acetyltransferase complex | BP: | MF: def: "CC_def: A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.1098316302098 density:0.452380952380952 bootstrap:0.339434136 cc_score:0.300286 bp_score:0.0736669 mf_score:0.0638596 relationship: child_of NeXO:9956 ! CC: | BP: | MF: [Term] id: NeXO:8123 name: CC: | BP: glucose transport | MF:glucose transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:10.3485782048736 density:0.952380952380952 bootstrap:0.91015715 cc_score:0.0 bp_score:0.133048 mf_score:0.349257 relationship: child_of NeXO:8937 ! CC: | BP: hexose transport | MF:glucose transport [Term] id: NeXO:9884 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79214980607125 density:0.0311676909569798 bootstrap:0.064607346 cc_score:0.0 bp_score:0.0414568 mf_score:0.0 relationship: child_of NeXO:9930 ! CC: | BP: | MF: [Term] id: NeXO:5774 name: CC: mitochondrial proton-transporting ATP synthase, stator stalk | BP: | MF: def: "CC_def: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08584035720229 density:1 bootstrap:0.720914862 cc_score:0.228448 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8437 ! CC: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | BP: proton-transporting ATPase activity, rotational mechanism | MF:proton-transporting ATPase activity, rotational mechanism relationship: linked_to NeXO:6209 ! CC: mitochondrial proton-transporting ATP synthase, catalytic core | BP: protein complex oligomerization | MF: [Term] id: NeXO:8693 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.26749008920947 density:0.833333333333333 bootstrap:0.64157356 cc_score:0.0 bp_score:0.0366532 mf_score:0.0 relationship: child_of NeXO:8838 ! CC: | BP: cis assembly of pre-catalytic spliceosome | MF: [Term] id: NeXO:8139 name: CC: | BP: negative regulation of TOR signaling cascade | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the TOR signaling pathway. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.189913659 cc_score:0.0 bp_score:0.14428 mf_score:0.0 relationship: child_of NeXO:9262 ! CC: | BP: | MF: [Term] id: NeXO:8692 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.42845017349995 density:0.333333333333333 bootstrap:0.413151427 cc_score:0.0 bp_score:0.0911794 mf_score:0.0 relationship: child_of NeXO:9173 ! CC: | BP: | MF: [Term] id: NeXO:9133 name: CC: | BP: positive regulation of sequence-specific DNA binding transcription factor activity | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.48954777081376 density:1 bootstrap:0.342325387 cc_score:0.0 bp_score:0.220444 mf_score:0.0 relationship: child_of NeXO:9363 ! CC: | BP: regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:8827 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9211 ! CC: proteasome regulatory particle, base subcomplex | BP: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: relationship: linked_to NeXO:7006 ! CC: | BP: | MF: [Term] id: NeXO:7927 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.591776785 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8399 ! CC: | BP: | MF: [Term] id: NeXO:7924 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.387770107 cc_score:0.0 bp_score:0.0121488 mf_score:0.0 relationship: child_of NeXO:8733 ! CC: | BP: | MF:calcium channel activity [Term] id: NeXO:7925 name: CC: N-terminal protein acetyltransferase complex | BP: N-terminal protein amino acid acetylation | MF:peptide alpha-N-acetyltransferase activity def: "CC_def: A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. | BP_def: The acetylation of the N-terminal amino acid of proteins. | MF_def:Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.48243944339181 density:0.266666666666667 bootstrap:0.363732489 cc_score:0.309563 bp_score:0.288754 mf_score:0.283749 relationship: child_of NeXO:8599 ! CC: | BP: N-terminal protein amino acid modification | MF: [Term] id: NeXO:7294 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.76795365635292 density:0.109090909090909 bootstrap:0.742210725 cc_score:0.0 bp_score:0.0942793 mf_score:0.0 relationship: child_of NeXO:8126 ! CC: | BP: | MF: [Term] id: NeXO:9136 name: CC: | BP: septin checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56330990561425 density:1 bootstrap:0.701302472 cc_score:0.060387 bp_score:0.663453 mf_score:0.0 relationship: child_of NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding [Term] id: NeXO:7920 name: CC: | BP: termination of RNA polymerase II transcription, poly(A)-coupled | MF:5'-3' exoribonuclease activity def: "CC_def: | BP_def: The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination. | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:3.83481275807159 density:1 bootstrap:0.81224399 cc_score:0.0 bp_score:0.249022 mf_score:0.22162 relationship: child_of NeXO:8176 ! CC: | BP: transcription termination, DNA-dependent | MF: [Term] id: NeXO:7297 name: CC: outer plaque of spindle pole body | BP: | MF: def: "CC_def: One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.89638671525674 density:1 bootstrap:0.83853711 cc_score:0.531257 bp_score:0.0405881 mf_score:0.0 relationship: child_of NeXO:8027 ! CC: gamma-tubulin small complex, spindle pole body | BP: | MF: [Term] id: NeXO:7298 name: CC: Golgi cisterna membrane | BP: inositol phosphorylceramide metabolic process | MF:inositol phosphoceramide synthase activity def: "CC_def: The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. | BP_def: The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group. The phosphate-containing group is the trivalent -P(O)= and the ceramide group of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid. | MF_def:Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [NeXO-GO:term] namespace: NeXO comment: robustness:2.03670381895516 density:0.333333333333333 bootstrap:0.839914 cc_score:0.314234 bp_score:0.13156 mf_score:0.230362 relationship: child_of NeXO:9691 ! CC: | BP: | MF: relationship: linked_to NeXO:8780 ! CC: Golgi transport complex | BP: intra-Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9139 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.85116526992942 density:0.833333333333333 bootstrap:0.286382318 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9293 ! CC: | BP: | MF: relationship: linked_to NeXO:9106 ! CC: | BP: | MF: relationship: linked_to NeXO:9083 ! CC: | BP: | MF: [Term] id: NeXO:9138 name: CC: | BP: age-dependent response to oxidative stress | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.33924802577243 density:0.464285714285714 bootstrap:0.308406267 cc_score:0.0 bp_score:0.268733 mf_score:0.0 relationship: child_of NeXO:9632 ! CC: | BP: cellular hypotonic response | MF: [Term] id: NeXO:7928 name: CC: | BP: cellular cobalt ion homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.55620414530912 density:1 bootstrap:0.4012869 cc_score:0.0 bp_score:0.437996 mf_score:0.0 relationship: child_of NeXO:8467 ! CC: | BP: | MF:3 iron, 4 sulfur cluster binding relationship: linked_to NeXO:6695 ! CC: | BP: | MF: [Term] id: NeXO:7929 name: CC: | BP: | MF:TBP-class protein binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.06716441540053 density:0.133333333333333 bootstrap:0.57459536 cc_score:0.0 bp_score:0.0 mf_score:0.106042 relationship: child_of NeXO:9248 ! CC: | BP: | MF: [Term] id: NeXO:9058 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.63813250355416 density:0.142857142857143 bootstrap:0.265409907 cc_score:0.0 bp_score:0.0278263 mf_score:0.0518257 relationship: child_of NeXO:9634 ! CC: | BP: | MF: [Term] id: NeXO:7700 name: CC: | BP: sequestering of actin monomers | MF:actin monomer binding def: "CC_def: | BP_def: The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. | MF_def:Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49630189 cc_score:0.0 bp_score:0.439237 mf_score:0.442145 relationship: child_of NeXO:8432 ! CC: actin filament bundle | BP: actin filament depolymerization | MF:actin filament binding [Term] id: NeXO:6299 name: CC: | BP: nucleoside diphosphate phosphorylation | MF:nucleoside diphosphate kinase activity def: "CC_def: | BP_def: The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate. | MF_def:Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78063336 cc_score:0.0 bp_score:0.441869 mf_score:0.439623 relationship: child_of NeXO:6828 ! CC: | BP: UTP biosynthetic process | MF: [Term] id: NeXO:9059 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.70142374119223 density:0.6 bootstrap:0.71597608 cc_score:0.0 bp_score:0.0573822 mf_score:0.0 relationship: child_of NeXO:9461 ! CC: | BP: | MF: [Term] id: NeXO:6297 name: CC: | BP: glycerol-3-phosphate metabolic process | MF:glycerol kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. | MF_def:Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9188743 cc_score:0.0 bp_score:0.172561 mf_score:0.437668 relationship: child_of NeXO:6298 ! CC: | BP: | MF: [Term] id: NeXO:6296 name: CC: | BP: maintenance of DNA repeat elements | MF: def: "CC_def: | BP_def: Any process involved in sustaining the fidelity and copy number of DNA repeat elements. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5968569361977 density:0.138888888888889 bootstrap:0.743645256 cc_score:0.0 bp_score:0.110826 mf_score:0.0 relationship: child_of NeXO:7387 ! CC: | BP: | MF: [Term] id: NeXO:6295 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02559881540268 density:0.333333333333333 bootstrap:0.83077981 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6296 ! CC: | BP: maintenance of DNA repeat elements | MF: [Term] id: NeXO:6294 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89737208 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6295 ! CC: | BP: | MF: [Term] id: NeXO:6293 name: CC: | BP: GTP biosynthetic process | MF:GMP biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. | MF_def:The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.36546662684753 density:1 bootstrap:0.92716173 cc_score:0.0 bp_score:0.220101 mf_score:0.175 relationship: child_of NeXO:7900 ! CC: | BP: lipopolysaccharide biosynthetic process | MF: [Term] id: NeXO:6292 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01396947522419 density:1 bootstrap:0.67209028 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6460 ! CC: TORC2 complex | BP: | MF: [Term] id: NeXO:6290 name: CC: | BP: negative regulation of proteasomal ubiquitin-dependent protein catabolic process | MF:aminoacyl-tRNA hydrolase activity def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. | MF_def:Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53307705 cc_score:0.0 bp_score:0.440532 mf_score:0.293093 relationship: child_of NeXO:6827 ! CC: | BP: negative regulation of proteolysis | MF: [Term] id: NeXO:6059 name: CC: | BP: | MF:vitamin transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [NeXO-GO:term] namespace: NeXO comment: robustness:1.94580700033559 density:0.333333333333333 bootstrap:0.766617251 cc_score:0.0 bp_score:0.0 mf_score:0.105095 relationship: child_of NeXO:7660 ! CC: | BP: | MF: [Term] id: NeXO:9689 name: CC: preribosome, small subunit precursor | BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. | BP_def: Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.258162443294 density:0.803030303030303 bootstrap:0.519430165 cc_score:0.162689 bp_score:0.153197 mf_score:0.0 relationship: child_of NeXO:9887 ! CC: small-subunit processome | BP: rRNA 5'-end processing | MF:snoRNA binding [Term] id: NeXO:6055 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.47386294990912 density:0.166666666666667 bootstrap:0.51121484 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6965 ! CC: | BP: | MF: [Term] id: NeXO:6054 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.92801543788095 density:0.666666666666667 bootstrap:0.78130331 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7518 ! CC: | BP: peptidyl-diphthamide biosynthetic process from peptidyl-histidine | MF: [Term] id: NeXO:6057 name: CC: | BP: tetrahydrofolate biosynthetic process | MF:nicotinate-nucleotide diphosphorylase (carboxylating) activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. | MF_def:Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.740571173 cc_score:0.0 bp_score:0.114741 mf_score:0.115068 relationship: child_of NeXO:7907 ! CC: | BP: | MF: [Term] id: NeXO:6056 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.54788769725837 density:0.333333333333333 bootstrap:0.48512981 cc_score:0.0 bp_score:0.083302 mf_score:0.0616533 relationship: child_of NeXO:6927 ! CC: | BP: | MF: [Term] id: NeXO:6051 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.30255623102979 density:0.3 bootstrap:0.81820708 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7763 ! CC: | BP: | MF: [Term] id: NeXO:6053 name: CC: | BP: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay | MF: def: "CC_def: | BP_def: A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.58565953397395 density:0.333333333333333 bootstrap:0.50909514 cc_score:0.0 bp_score:0.192977 mf_score:0.0 relationship: child_of NeXO:6912 ! CC: | BP: | MF:carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: NeXO:6052 name: CC: cyclin-dependent protein kinase holoenzyme complex | BP: regulation of autophagy | MF:protein kinase binding def: "CC_def: Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. | BP_def: Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. | MF_def:Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.49593060587127 density:0.0666666666666667 bootstrap:0.669264671 cc_score:0.161918 bp_score:0.112566 mf_score:0.12573 relationship: child_of NeXO:6555 ! CC: | BP: negative regulation of conjugation with cellular fusion | MF: [Term] id: NeXO:5115 name: CC: | BP: | MF:glutathione-disulfide reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.94080849 cc_score:0.0 bp_score:0.0 mf_score:0.176947 relationship: child_of NeXO:5810 ! CC: | BP: | MF: [Term] id: NeXO:10005 name: CC: cytosolic large ribosomal subunit | BP: | MF: def: "CC_def: The large subunit of a ribosome located in the cytosol. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:21.026444134975 density:0.529139685476411 bootstrap:0.60293812 cc_score:0.180882 bp_score:0.0690417 mf_score:0.0367557 relationship: child_of NeXO:10022 ! CC: cytosolic ribosome | BP: cytoplasmic translation | MF:structural constituent of ribosome [Term] id: NeXO:10007 name: CC: preribosome | BP: rRNA processing | MF: def: "CC_def: Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. | BP_def: Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.3031724470185 density:0.113556920170052 bootstrap:0.456871238 cc_score:0.356399 bp_score:0.217979 mf_score:0.0513863 relationship: child_of NeXO:10023 ! CC: GO:0044391 | BP: ribosome biogenesis | MF: [Term] id: NeXO:10000 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.60670600037282 density:0.833333333333333 bootstrap:0.747622578 cc_score:0.0 bp_score:0.0125406 mf_score:0.0 relationship: child_of NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9317 ! CC: | BP: | MF: relationship: linked_to NeXO:5736 ! CC: | BP: ribonucleoside catabolic process | MF:nicotinamide riboside hydrolase activity relationship: linked_to NeXO:8988 ! CC: phosphopyruvate hydratase complex | BP: | MF:phosphopyruvate hydratase activity relationship: linked_to NeXO:9332 ! CC: | BP: | MF:ATPase inhibitor activity [Term] id: NeXO:10001 name: CC: membrane | BP: primary metabolic process | MF:metabolic process def: "CC_def: Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. | BP_def: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. | MF_def:The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [NeXO-GO:term] namespace: NeXO comment: robustness:0.0598952118417877 density:0.00227166844926804 bootstrap:0.30950483 cc_score:0.172706 bp_score:0.144562 mf_score:0.117478 relationship: child_of NeXO:10034 ! CC: cell part | BP: cellular process | MF:binding [Term] id: NeXO:5113 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85211574 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5412 ! CC: | BP: | MF:nucleotide phosphatase activity [Term] id: NeXO:10003 name: CC: cytosolic small ribosomal subunit | BP: | MF: def: "CC_def: The small subunit of a ribosome located in the cytosol. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:20.3950793641493 density:0.340501792114695 bootstrap:0.567272688 cc_score:0.238156 bp_score:0.0974211 mf_score:0.0140499 relationship: child_of NeXO:10022 ! CC: cytosolic ribosome | BP: cytoplasmic translation | MF:structural constituent of ribosome [Term] id: NeXO:5118 name: CC: | BP: amino acid export | MF:L-tyrosine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of amino acids out of a cell or organelle. | MF_def:Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80872599 cc_score:0.0 bp_score:0.113873 mf_score:0.136531 relationship: child_of NeXO:5151 ! CC: | BP: | MF: [Term] id: NeXO:5819 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64968173 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7994 ! CC: | BP: | MF: [Term] id: NeXO:5464 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.16196335588191 density:0.666666666666667 bootstrap:0.91114313 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7625 ! CC: | BP: | MF: [Term] id: NeXO:9598 name: CC: | BP: positive regulation of transcription by galactose | MF: def: "CC_def: | BP_def: Any process involving galactose that activates or increases the rate of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.17707109806489 density:0.6 bootstrap:0.32695922 cc_score:0.0 bp_score:0.236387 mf_score:0.0493736 relationship: child_of NeXO:9843 ! CC: mediator complex | BP: negative regulation of transcription from RNA polymerase II promoter | MF:RNA polymerase II transcription factor binding transcription factor activity relationship: linked_to NeXO:9559 ! CC: | BP: | MF:RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly relationship: linked_to NeXO:9383 ! CC: | BP: | MF: [Term] id: NeXO:9229 name: CC: 1,3-beta-D-glucan synthase complex | BP: 1,3-beta-D-glucan biosynthetic process | MF:1,3-beta-D-glucan synthase activity def: "CC_def: A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a 1,3-beta-D-glucan chain. | BP_def: The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. | MF_def:Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.44247898854978 density:0.666666666666667 bootstrap:0.543669053 cc_score:0.150559 bp_score:0.152093 mf_score:0.184225 relationship: child_of NeXO:9623 ! CC: | BP: | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:9365 ! CC: | BP: galactose catabolic process | MF: relationship: linked_to NeXO:9216 ! CC: | BP: | MF: [Term] id: NeXO:8955 name: CC: | BP: arginine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.35495748515768 density:0.303030303030303 bootstrap:0.489121078 cc_score:0.0 bp_score:0.130859 mf_score:0.0654269 relationship: child_of NeXO:9000 ! CC: | BP: | MF: [Term] id: NeXO:9595 name: CC: | BP: regulation of retrograde vesicle-mediated transport, Golgi to ER | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43233723879708 density:0.333333333333333 bootstrap:0.218990594 cc_score:0.0 bp_score:0.207538 mf_score:0.0 relationship: child_of NeXO:9807 ! CC: | BP: regulation of ER to Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9226 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.34021537546198 density:0.2 bootstrap:0.217030245 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9876 ! CC: | BP: | MF: [Term] id: NeXO:9597 name: CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding def: "CC_def: A ribonucleoprotein complex that contains small nuclear RNA U5. | BP_def: The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. | MF_def:Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [NeXO-GO:term] namespace: NeXO comment: robustness:7.94872996918982 density:1 bootstrap:0.69792569 cc_score:0.244824 bp_score:0.226426 mf_score:0.297814 relationship: child_of NeXO:9733 ! CC: trans spliceosomal complex | BP: spliceosomal snRNP assembly | MF: relationship: linked_to NeXO:8813 ! CC: Prp19 complex | BP: | MF:first spliceosomal transesterification activity relationship: linked_to NeXO:9105 ! CC: U6 snRNP | BP: | MF: relationship: linked_to NeXO:9414 ! CC: | BP: ribonucleoprotein complex disassembly | MF: relationship: linked_to NeXO:9188 ! CC: | BP: generation of catalytic spliceosome for second transesterification step | MF:second spliceosomal transesterification activity [Term] id: NeXO:9224 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.56309888437849 density:0.7 bootstrap:0.55577477 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9321 ! CC: | BP: | MF: [Term] id: NeXO:9591 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.80687599710716 density:0.138528138528139 bootstrap:0.140359312 cc_score:0.0 bp_score:0.0149238 mf_score:0.0373259 relationship: child_of NeXO:9765 ! CC: | BP: | MF: [Term] id: NeXO:9590 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.51441508588404 density:0.111111111111111 bootstrap:0.122010498 cc_score:0.0 bp_score:0.0348923 mf_score:0.0 relationship: child_of NeXO:9803 ! CC: | BP: | MF: [Term] id: NeXO:9221 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.60418392309322 density:0.583333333333333 bootstrap:0.70955154 cc_score:0.0 bp_score:0.0 mf_score:0.0740682 relationship: child_of NeXO:9725 ! CC: | BP: | MF: [Term] id: NeXO:9220 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.50787617894367 density:0.5 bootstrap:0.416111723 cc_score:0.0473902 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9618 ! CC: commitment complex | BP: | MF: relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: [Term] id: NeXO:5219 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81203442 cc_score:0.0 bp_score:0.0190882 mf_score:0.0 relationship: child_of NeXO:6381 ! CC: | BP: urea metabolic process | MF:ornithine carbamoyltransferase activity [Term] id: NeXO:9225 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.59245650995848 density:1 bootstrap:0.7201211 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9663 ! CC: | BP: | MF: relationship: linked_to NeXO:9321 ! CC: | BP: | MF: relationship: linked_to NeXO:9463 ! CC: | BP: | MF: relationship: linked_to NeXO:9539 ! CC: | BP: | MF: [Term] id: NeXO:9814 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.69197832841126 density:0.0283658787255910 bootstrap:0.172605229 cc_score:0.0 bp_score:0.0396835 mf_score:0.0185312 relationship: child_of NeXO:9932 ! CC: | BP: | MF: [Term] id: NeXO:5201 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8447233 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5387 ! CC: | BP: cellular response to xenobiotic stimulus | MF: [Term] id: NeXO:5200 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68432771 cc_score:0.0 bp_score:0.0 mf_score:0.0929977 relationship: child_of NeXO:6761 ! CC: | BP: | MF: [Term] id: NeXO:5203 name: CC: | BP: mitochondrial glycyl-tRNA aminoacylation | MF:glycine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83000981 cc_score:0.0 bp_score:0.444109 mf_score:0.292805 relationship: child_of NeXO:5800 ! CC: | BP: glycyl-tRNA aminoacylation | MF:tryptophan synthase activity [Term] id: NeXO:5202 name: CC: mitochondrial proton-transporting ATP synthase, central stalk | BP: | MF: def: "CC_def: One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.734844919 cc_score:0.588464 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5296 ! CC: | BP: protein oligomerization | MF: [Term] id: NeXO:5205 name: CC: | BP: de novo NAD biosynthetic process from tryptophan | MF:homoserine kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. | MF_def:Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83633729 cc_score:0.0 bp_score:0.149433 mf_score:0.443506 relationship: child_of NeXO:5380 ! CC: | BP: GTP cyclohydrolase I activity | MF:GTP cyclohydrolase I activity [Term] id: NeXO:5207 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.13016313449073 density:0.666666666666667 bootstrap:0.89290835 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5417 ! CC: | BP: | MF: [Term] id: NeXO:5206 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06508623506851 density:0.666666666666667 bootstrap:0.856166706 cc_score:0.0462555 bp_score:0.0463478 mf_score:0.0273936 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:5209 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86940427 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5210 ! CC: | BP: | MF: [Term] id: NeXO:5208 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75522724 cc_score:0.0 bp_score:0.050606 mf_score:0.0 relationship: child_of NeXO:5469 ! CC: | BP: | MF: [Term] id: NeXO:9041 name: CC: | BP: S-adenosylmethionine metabolic process | MF:3-dehydroquinate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. | MF_def:Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.80003018637795 density:1 bootstrap:0.536885189 cc_score:0.0 bp_score:0.159307 mf_score:0.44682 relationship: child_of NeXO:9443 ! CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity relationship: linked_to NeXO:8307 ! CC: | BP: | MF:methionine adenosyltransferase activity relationship: linked_to NeXO:8051 ! CC: | BP: threonine catabolic process | MF:flavin reductase activity relationship: linked_to NeXO:7724 ! CC: anthranilate synthase complex | BP: tryptophan biosynthetic process | MF:tryptophan biosynthetic process [Term] id: NeXO:9047 name: CC: | BP: heterochromatin maintenance involved in chromatin silencing | MF: def: "CC_def: | BP_def: A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25657325278809 density:1 bootstrap:0.84376347 cc_score:0.0 bp_score:0.294751 mf_score:0.0 relationship: child_of NeXO:9569 ! CC: | BP: termination of RNA polymerase I transcription | MF: relationship: linked_to NeXO:6965 ! CC: | BP: | MF: relationship: linked_to NeXO:7605 ! CC: | BP: nucleosome positioning | MF: relationship: linked_to NeXO:8958 ! CC: | BP: | MF:protein complex scaffold relationship: linked_to NeXO:8959 ! CC: | BP: | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:9046 name: CC: | BP: Golgi inheritance | MF: def: "CC_def: | BP_def: The partitioning of Golgi apparatus between daughter cells at cell division. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.00498231605598 density:1 bootstrap:0.69178264 cc_score:0.0 bp_score:0.148314 mf_score:0.0 relationship: child_of NeXO:9694 ! CC: | BP: | MF: relationship: linked_to NeXO:9418 ! CC: | BP: inter-Golgi cisterna vesicle-mediated transport | MF: relationship: linked_to NeXO:8664 ! CC: COPI vesicle coat | BP: | MF: relationship: linked_to NeXO:9222 ! CC: | BP: | MF: [Term] id: NeXO:9044 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.41614417891064 density:0.361111111111111 bootstrap:0.342458159 cc_score:0.0 bp_score:0.083022 mf_score:0.0 relationship: child_of NeXO:9721 ! CC: | BP: intracellular protein transmembrane transport | MF:protein transmembrane transporter activity [Term] id: NeXO:6191 name: CC: | BP: glyoxylate metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97347783230205 density:0.333333333333333 bootstrap:0.788576026 cc_score:0.0 bp_score:0.145454 mf_score:0.0 relationship: child_of NeXO:6192 ! CC: | BP: | MF:isocitrate dehydrogenase (NAD+) activity [Term] id: NeXO:5255 name: CC: | BP: leucyl-tRNA aminoacylation | MF:leucine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.712990083 cc_score:0.0 bp_score:0.877605 mf_score:0.877365 relationship: child_of NeXO:5445 ! CC: | BP: | MF: [Term] id: NeXO:8912 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.31745207721404 density:1 bootstrap:0.6078655 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9463 ! CC: | BP: | MF: [Term] id: NeXO:8913 name: CC: holo TFIIH complex | BP: phosphorylation of RNA polymerase II C-terminal domain | MF: def: "CC_def: A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB. | BP_def: The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.73939409171675 density:0.866666666666667 bootstrap:0.81153816 cc_score:0.46314 bp_score:0.256031 mf_score:0.0 relationship: child_of NeXO:9632 ! CC: | BP: cellular hypotonic response | MF: [Term] id: NeXO:8910 name: CC: Hrd1p ubiquitin ligase ERAD-M complex | BP: establishment of protein localization in endoplasmic reticulum membrane | MF:ubiquitin-protein ligase activator activity def: "CC_def: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. | BP_def: The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. | MF_def:Increases the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [NeXO-GO:term] namespace: NeXO comment: robustness:5.37177351520896 density:1 bootstrap:0.79689289 cc_score:0.4375 bp_score:0.222726 mf_score:0.148558 relationship: child_of NeXO:9447 ! CC: | BP: | MF: relationship: linked_to NeXO:9349 ! CC: | BP: | MF: relationship: linked_to NeXO:8419 ! CC: | BP: | MF: [Term] id: NeXO:8911 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.72743418934459 density:0.333333333333333 bootstrap:0.6042019 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9232 ! CC: | BP: | MF: [Term] id: NeXO:8914 name: CC: | BP: mannosyl-inositol phosphorylceramide metabolic process | MF:serine C-palmitoyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative. | MF_def:Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:1.34461806498586 density:0.333333333333333 bootstrap:0.366080797 cc_score:0.0 bp_score:0.163983 mf_score:0.232097 relationship: child_of NeXO:9499 ! CC: | BP: | MF: relationship: linked_to NeXO:6953 ! CC: SPOTS complex | BP: regulation of sphingolipid biosynthetic process | MF: [Term] id: NeXO:8915 name: CC: | BP: | MF:histone acetyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [NeXO-GO:term] namespace: NeXO comment: robustness:8.40939470690119 density:0.933333333333333 bootstrap:0.86465535 cc_score:0.0 bp_score:0.0 mf_score:0.109926 relationship: child_of NeXO:9638 ! CC: NuA4 histone acetyltransferase complex | BP: | MF: [Term] id: NeXO:9223 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.850326572393 density:0.285714285714286 bootstrap:0.243433228 cc_score:0.0 bp_score:0.0568379 mf_score:0.0 relationship: child_of NeXO:9633 ! CC: | BP: | MF: [Term] id: NeXO:8919 name: CC: Doa10p ubiquitin ligase complex | BP: | MF: def: "CC_def: A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.18903560061317 density:0.377777777777778 bootstrap:0.359330874 cc_score:0.199203 bp_score:0.0523381 mf_score:0.0 relationship: child_of NeXO:9629 ! CC: ER ubiquitin ligase complex | BP: ER-associated protein catabolic process | MF: [Term] id: NeXO:6192 name: CC: | BP: | MF:isocitrate dehydrogenase (NAD+) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:4.30492907932868 density:0.666666666666667 bootstrap:0.86454499 cc_score:0.0 bp_score:0.0 mf_score:0.217071 relationship: child_of NeXO:7731 ! CC: | BP: glutamate biosynthetic process | MF:citrate (Si)-synthase activity [Term] id: NeXO:5191 name: CC: | BP: glycine biosynthetic process, by transamination of glyoxylate | MF:alanine-glyoxylate transaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate. | MF_def:Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87024704 cc_score:0.0 bp_score:0.448751 mf_score:0.439781 relationship: child_of NeXO:5382 ! CC: | BP: regulation of establishment or maintenance of cell polarity | MF: [Term] id: NeXO:5190 name: CC: | BP: proteasome localization | MF:nicotinamidase activity def: "CC_def: | BP_def: Any process in which the proteasome is transported to, or maintained in, a specific location. | MF_def:Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.837605 cc_score:0.0 bp_score:0.440613 mf_score:0.439007 relationship: child_of NeXO:6057 ! CC: | BP: tetrahydrofolate biosynthetic process | MF:nicotinate-nucleotide diphosphorylase (carboxylating) activity [Term] id: NeXO:7113 name: CC: | BP: | MF:homocitrate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.32998528 cc_score:0.0 bp_score:0.0 mf_score:0.295608 relationship: child_of NeXO:7727 ! CC: | BP: | MF: [Term] id: NeXO:7112 name: CC: | BP: protein deglutathionylation | MF:serine-type endopeptidase inhibitor activity def: "CC_def: | BP_def: The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage. | MF_def:Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79420623 cc_score:0.0 bp_score:0.291788 mf_score:0.296656 relationship: child_of NeXO:7924 ! CC: | BP: | MF: [Term] id: NeXO:7111 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31384104017889 density:1 bootstrap:0.88713331 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8911 ! CC: | BP: | MF: [Term] id: NeXO:7110 name: CC: | BP: nuclear polyadenylation-dependent snRNA catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89126139 cc_score:0.0 bp_score:0.354195 mf_score:0.0 relationship: child_of NeXO:7729 ! CC: | BP: snoRNA polyadenylation | MF:ATP-dependent 3'-5' RNA helicase activity relationship: linked_to NeXO:7952 ! CC: | BP: nuclear polyadenylation-dependent antisense transcript catabolic process | MF:5'-deoxyribose-5-phosphate lyase activity [Term] id: NeXO:7117 name: CC: | BP: | MF:U2 snRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.676975174 cc_score:0.0 bp_score:0.0 mf_score:0.294615 relationship: child_of NeXO:8250 ! CC: U2-type post-spliceosomal complex | BP: | MF: relationship: linked_to NeXO:8393 ! CC: | BP: | MF: [Term] id: NeXO:7116 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.46520081348551 density:0.333333333333333 bootstrap:0.434683712 cc_score:0.0 bp_score:0.0313443 mf_score:0.0 relationship: child_of NeXO:7229 ! CC: | BP: | MF: [Term] id: NeXO:6879 name: CC: | BP: intracellular sterol transport | MF:dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity def: "CC_def: | BP_def: The directed movement of sterols within cells. | MF_def:Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88140012 cc_score:0.0 bp_score:0.221823 mf_score:0.219841 relationship: child_of NeXO:7695 ! CC: | BP: GPI anchor biosynthetic process | MF: [Term] id: NeXO:7114 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.675544691 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7902 ! CC: | BP: | MF: [Term] id: NeXO:6877 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.96028051325146 density:0.142857142857143 bootstrap:0.61456716 cc_score:0.0 bp_score:0.0843591 mf_score:0.073562 relationship: child_of NeXO:7673 ! CC: | BP: | MF: [Term] id: NeXO:6876 name: CC: | BP: | MF:protein phosphatase 2B binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [NeXO-GO:term] namespace: NeXO comment: robustness:1.74037326383988 density:0.166666666666667 bootstrap:0.712810445 cc_score:0.0 bp_score:0.0 mf_score:0.254328 relationship: child_of NeXO:7718 ! CC: | BP: telomere localization | MF: relationship: linked_to NeXO:8787 ! CC: | BP: | MF: [Term] id: NeXO:6875 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63354708 cc_score:0.0 bp_score:0.0418621 mf_score:0.0 relationship: child_of NeXO:7909 ! CC: | BP: regulation of phosphoprotein phosphatase activity | MF:protein phosphatase binding [Term] id: NeXO:7118 name: CC: Slx1-Slx4 complex | BP: response to UV-C | MF: def: "CC_def: A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes. | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.71925338030129 density:1 bootstrap:0.489780647 cc_score:0.291899 bp_score:0.44191 mf_score:0.0789793 relationship: child_of NeXO:8025 ! CC: | BP: resolution of recombination intermediates | MF: relationship: linked_to NeXO:9008 ! CC: Holliday junction resolvase complex | BP: resolution of meiotic recombination intermediates | MF:crossover junction endodeoxyribonuclease activity relationship: linked_to NeXO:8556 ! CC: | BP: | MF: [Term] id: NeXO:6873 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.534023465854 density:0.952380952380952 bootstrap:0.482401834 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7252 ! CC: | BP: | MF: [Term] id: NeXO:5379 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90675513 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6458 ! CC: | BP: | MF: [Term] id: NeXO:5378 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8045114 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5478 ! CC: | BP: | MF: [Term] id: NeXO:5375 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.11436627076121 density:1 bootstrap:0.93498379 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6726 ! CC: | BP: | MF: [Term] id: NeXO:5374 name: CC: | BP: | MF:trans-aconitate 3-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83153693 cc_score:0.0 bp_score:0.0815569 mf_score:0.268908 relationship: child_of NeXO:6072 ! CC: | BP: | MF:ornithine metabolic process [Term] id: NeXO:5377 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03249299957569 density:0.333333333333333 bootstrap:0.8364446 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6077 ! CC: | BP: mitochondrial lysyl-tRNA aminoacylation | MF: [Term] id: NeXO:5371 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.055222154609 density:0.333333333333333 bootstrap:0.855256947 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6765 ! CC: | BP: | MF: [Term] id: NeXO:5370 name: CC: | BP: fatty acid transport | MF:fatty acid transport def: "CC_def: | BP_def: The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. | MF_def:The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [NeXO-GO:term] namespace: NeXO comment: robustness:1.69713781202858 density:0.333333333333333 bootstrap:0.583194318 cc_score:0.0 bp_score:0.228817 mf_score:0.287307 relationship: child_of NeXO:5483 ! CC: | BP: | MF: [Term] id: NeXO:5373 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08499577542968 density:0.666666666666667 bootstrap:0.867325444 cc_score:0.0 bp_score:0.0442348 mf_score:0.0103112 relationship: child_of NeXO:5633 ! CC: | BP: phospholipid translocation | MF:phospholipid-translocating ATPase activity [Term] id: NeXO:7290 name: CC: | BP: glycine betaine transport | MF:ethanolamine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.34242365 cc_score:0.0 bp_score:0.442934 mf_score:0.438902 relationship: child_of NeXO:7965 ! CC: | BP: choline transport | MF:choline transmembrane transporter activity [Term] id: NeXO:9543 name: CC: | BP: | MF:RNA guanylyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0.968215033398649 density:0.1 bootstrap:0.250439119 cc_score:0.0 bp_score:0.0138276 mf_score:0.145898 relationship: child_of NeXO:9778 ! CC: | BP: | MF: [Term] id: NeXO:8220 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.57428758435287 density:0.141666666666667 bootstrap:0.372716105 cc_score:0.0 bp_score:0.0520111 mf_score:0.0443202 relationship: child_of NeXO:8932 ! CC: | BP: | MF: [Term] id: NeXO:8221 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93846152 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9237 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag relationship: linked_to NeXO:9615 ! CC: | BP: | MF: [Term] id: NeXO:8222 name: CC: | BP: mating type determination | MF: def: "CC_def: | BP_def: Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.76261945591308 density:0.181818181818182 bootstrap:0.62399571 cc_score:0.0 bp_score:0.122892 mf_score:0.0797149 relationship: child_of NeXO:8955 ! CC: | BP: arginine metabolic process | MF: [Term] id: NeXO:8226 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03038137735586 density:1 bootstrap:0.683088682 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9018 ! CC: | BP: | MF: relationship: linked_to NeXO:8841 ! CC: | BP: autophagic vacuole fusion | MF: [Term] id: NeXO:8227 name: CC: GARP complex | BP: | MF: def: "CC_def: A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.55365526622141 density:1 bootstrap:0.85177012 cc_score:0.526026 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9018 ! CC: | BP: | MF: relationship: linked_to NeXO:9222 ! CC: | BP: | MF: [Term] id: NeXO:8228 name: CC: myosin II complex | BP: cytokinesis, actomyosin contractile ring assembly | MF:myosin V binding def: "CC_def: A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. | BP_def: The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. | MF_def:Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [NeXO-GO:term] namespace: NeXO comment: robustness:1.64853575608147 density:1 bootstrap:0.450317256 cc_score:0.449402 bp_score:0.350764 mf_score:0.445393 relationship: child_of NeXO:8686 ! CC: actomyosin contractile ring | BP: negative regulation of Arp2/3 complex-mediated actin nucleation | MF:myosin II heavy chain binding [Term] id: NeXO:8229 name: CC: | BP: | MF:nitric oxide dioxygenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.299204555 cc_score:0.0 bp_score:0.0 mf_score:0.162746 relationship: child_of NeXO:9145 ! CC: | BP: dicarboxylic acid metabolic process | MF: [Term] id: NeXO:7291 name: CC: external side of mitochondrial outer membrane | BP: protein localization to chromosome, centromeric region | MF: def: "CC_def: The external (cytoplasmic face) of the mitochondrial outer membrane. | BP_def: Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.356567932 cc_score:0.292061 bp_score:0.147678 mf_score:0.0 relationship: child_of NeXO:7872 ! CC: | BP: positive regulation of sodium ion transport | MF: [Term] id: NeXO:6473 name: CC: | BP: negative regulation of sphingolipid biosynthetic process | MF: def: "CC_def: | BP_def: Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64304797119035 density:0.333333333333333 bootstrap:0.546612491 cc_score:0.0 bp_score:0.575665 mf_score:0.0 relationship: child_of NeXO:6953 ! CC: SPOTS complex | BP: regulation of sphingolipid biosynthetic process | MF: [Term] id: NeXO:6017 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07708620030068 density:0.333333333333333 bootstrap:0.873550679 cc_score:0.0 bp_score:0.0110086 mf_score:0.0 relationship: child_of NeXO:6804 ! CC: | BP: | MF: [Term] id: NeXO:7609 name: CC: | BP: negative regulation of lipid metabolic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9764583593264 density:0.0555555555555556 bootstrap:0.68793202 cc_score:0.0 bp_score:0.113354 mf_score:0.0 relationship: child_of NeXO:8691 ! CC: | BP: glutamate metabolic process | MF: [Term] id: NeXO:7608 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93620408389871 density:0.3 bootstrap:0.281232207 cc_score:0.0 bp_score:0.08104 mf_score:0.0 relationship: child_of NeXO:8220 ! CC: | BP: | MF: [Term] id: NeXO:7607 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.13051826132535 density:1 bootstrap:0.75212906 cc_score:0.0 bp_score:0.0 mf_score:0.0883722 relationship: child_of NeXO:8436 ! CC: | BP: | MF: [Term] id: NeXO:7605 name: CC: | BP: nucleosome positioning | MF: def: "CC_def: | BP_def: Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.36458040130282 density:1 bootstrap:0.794760148 cc_score:0.0 bp_score:0.148127 mf_score:0.0 relationship: child_of NeXO:8506 ! CC: | BP: | MF: [Term] id: NeXO:7604 name: CC: nuclear membrane part | BP: establishment of spindle pole body localization in nuclear envelope | MF: def: "CC_def: Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. | BP_def: A process in which a spindle pole body is transported to a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.497884243 cc_score:0.132085 bp_score:0.43791 mf_score:0.0 relationship: child_of NeXO:8031 ! CC: | BP: | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity [Term] id: NeXO:7602 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9739636496804 density:1 bootstrap:0.64565445 cc_score:0.0 bp_score:0.0420872 mf_score:0.0438347 relationship: child_of NeXO:8058 ! CC: | BP: | MF: [Term] id: NeXO:7601 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83737296 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8034 ! CC: | BP: regulation of endocytosis | MF: relationship: linked_to NeXO:9373 ! CC: | BP: positive regulation of actin filament bundle assembly | MF: [Term] id: NeXO:7600 name: CC: | BP: | MF:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [NeXO-GO:term] namespace: NeXO comment: robustness:1.2275517397562 density:0.166666666666667 bootstrap:0.354624602 cc_score:0.0 bp_score:0.0593014 mf_score:0.264694 relationship: child_of NeXO:8467 ! CC: | BP: | MF:3 iron, 4 sulfur cluster binding [Term] id: NeXO:6396 name: CC: | BP: dolichol-linked oligosaccharide biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.94601370567472 density:0.266666666666667 bootstrap:0.51226454 cc_score:0.0 bp_score:0.171345 mf_score:0.0 relationship: child_of NeXO:6846 ! CC: | BP: | MF: [Term] id: NeXO:7708 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56298498 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8211 ! CC: | BP: | MF: [Term] id: NeXO:6608 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28401772693512 density:0.111111111111111 bootstrap:0.321240438 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7439 ! CC: | BP: | MF: [Term] id: NeXO:6451 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.64303021704676 density:0.166666666666667 bootstrap:0.635302187 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7638 ! CC: | BP: regulation of translation in response to stress | MF: [Term] id: NeXO:6450 name: CC: | BP: establishment of mitochondrion localization | MF: def: "CC_def: | BP_def: The directed movement of the mitochondrion to a specific location. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.85121297240309 density:0.333333333333333 bootstrap:0.86774918 cc_score:0.0 bp_score:0.101697 mf_score:0.0840101 relationship: child_of NeXO:6762 ! CC: | BP: | MF: [Term] id: NeXO:6453 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.72266213452479 density:0.666666666666667 bootstrap:0.67555458 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6968 ! CC: | BP: | MF:polynucleotide 3'-phosphatase activity [Term] id: NeXO:6904 name: CC: | BP: nuclear mRNA branch site recognition | MF: def: "CC_def: | BP_def: Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84998122 cc_score:0.0 bp_score:0.221228 mf_score:0.0 relationship: child_of NeXO:7644 ! CC: | BP: | MF: [Term] id: NeXO:6455 name: CC: | BP: lipid homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82812337035821 density:1 bootstrap:0.80941273 cc_score:0.0 bp_score:0.146723 mf_score:0.0 relationship: child_of NeXO:6765 ! CC: | BP: | MF: [Term] id: NeXO:8687 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.20118151616086 density:1 bootstrap:0.802848428 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9314 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:5768 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.312849652392 density:1 bootstrap:0.886373271 cc_score:0.0 bp_score:0.0129265 mf_score:0.0 relationship: child_of NeXO:5798 ! CC: periplasmic space | BP: cellular response to nitrogen starvation | MF: [Term] id: NeXO:8685 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.68324914817204 density:0.0571428571428571 bootstrap:0.248255716 cc_score:0.0 bp_score:0.0420458 mf_score:0.0 relationship: child_of NeXO:9404 ! CC: | BP: | MF: [Term] id: NeXO:9858 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.8087081353176 density:0.213235294117647 bootstrap:0.314498259 cc_score:0.0 bp_score:0.0487368 mf_score:0.0730548 relationship: child_of NeXO:9971 ! CC: | BP: protein refolding | MF: [Term] id: NeXO:9859 name: CC: transcription elongation factor complex | BP: regulation of histone ubiquitination | MF: def: "CC_def: Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. | BP_def: Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.9920347465737 density:0.833333333333333 bootstrap:0.64337096 cc_score:0.249591 bp_score:0.31889 mf_score:0.0884995 relationship: child_of NeXO:9875 ! CC: UTP-C complex | BP: transcription elongation from RNA polymerase I promoter | MF:RNA polymerase II core binding [Term] id: NeXO:8688 name: CC: multi-eIF complex | BP: mature ribosome assembly | MF: def: "CC_def: A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. | BP_def: The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.14788049633888 density:1 bootstrap:0.62627031 cc_score:0.389113 bp_score:0.146694 mf_score:0.0 relationship: child_of NeXO:9402 ! CC: | BP: | MF: [Term] id: NeXO:8137 name: CC: | BP: uracil metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.17755702309504 density:0.0666666666666667 bootstrap:0.414704644 cc_score:0.0 bp_score:0.118023 mf_score:0.0 relationship: child_of NeXO:8826 ! CC: | BP: | MF: [Term] id: NeXO:8130 name: CC: | BP: response to cycloheximide | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07418525650311 density:1 bootstrap:0.712880824 cc_score:0.0 bp_score:0.300778 mf_score:0.0 relationship: child_of NeXO:9057 ! CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity relationship: linked_to NeXO:5823 ! CC: | BP: | MF: relationship: linked_to NeXO:7024 ! CC: | BP: | MF:xenobiotic-transporting ATPase activity [Term] id: NeXO:5763 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.96431478861681 density:0.5 bootstrap:0.581361693 cc_score:0.0 bp_score:0.0808724 mf_score:0.0 relationship: child_of NeXO:5764 ! CC: | BP: pyridoxine biosynthetic process | MF: [Term] id: NeXO:6909 name: CC: | BP: cellular response to metal ion | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22530284916597 density:0.0606060606060606 bootstrap:0.45976051 cc_score:0.0 bp_score:0.110704 mf_score:0.0 relationship: child_of NeXO:7901 ! CC: | BP: | MF: [Term] id: NeXO:8133 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6786895 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9724 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:9197 ! CC: | BP: | MF: [Term] id: NeXO:5568 name: CC: | BP: | MF:fluconazole transporter activity def: "CC_def: | BP_def: | MF_def:Enables the directed movement of fluconazole into, out of or within a cell, or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.774803141 cc_score:0.0 bp_score:0.0664962 mf_score:0.445824 relationship: child_of NeXO:6758 ! CC: | BP: | MF:oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor [Term] id: NeXO:5569 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69806846 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5570 ! CC: | BP: | MF: [Term] id: NeXO:5564 name: CC: | BP: | MF:carbonyl reductase (NADPH) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.01185239771775 density:0.333333333333333 bootstrap:0.81954215 cc_score:0.0 bp_score:0.0 mf_score:0.1286 relationship: child_of NeXO:6937 ! CC: | BP: | MF: [Term] id: NeXO:5565 name: CC: | BP: double-strand break repair via single-strand annealing | MF:DNA translocase activity def: "CC_def: | BP_def: Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9084413 cc_score:0.0 bp_score:0.121832 mf_score:0.177298 relationship: child_of NeXO:9495 ! CC: | BP: negative regulation of transposition, RNA-mediated | MF: relationship: linked_to NeXO:8606 ! CC: Mre11 complex | BP: single-stranded telomeric DNA binding | MF:G-quadruplex DNA binding [Term] id: NeXO:5567 name: CC: | BP: inositol phosphate dephosphorylation | MF:inositol-1(or 4)-monophosphatase activity def: "CC_def: | BP_def: The process of removing a phosphate group from any mono- or polyphosphorylated inositol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.730682861 cc_score:0.0 bp_score:0.221649 mf_score:0.292078 relationship: child_of NeXO:6197 ! CC: | BP: phosphorylated carbohydrate dephosphorylation | MF: [Term] id: NeXO:5561 name: CC: | BP: S-adenosylmethionine transport | MF:phosphopantetheine binding def: "CC_def: | BP_def: The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Interacting selectively with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77055362 cc_score:0.0 bp_score:0.293577 mf_score:0.294881 relationship: child_of NeXO:6537 ! CC: | BP: lipoate biosynthetic process | MF:S-adenosylmethionine transmembrane transporter activity [Term] id: NeXO:5562 name: CC: | BP: aspartyl-tRNA aminoacylation | MF:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity def: "CC_def: | BP_def: The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.475460295 cc_score:0.0 bp_score:0.293442 mf_score:0.448852 relationship: child_of NeXO:5743 ! CC: | BP: selenocysteine metabolic process | MF:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [Term] id: NeXO:5563 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.886057692 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5564 ! CC: | BP: | MF:carbonyl reductase (NADPH) activity [Term] id: NeXO:7739 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53104364393745 density:0.3 bootstrap:0.480575979 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8682 ! CC: | BP: | MF: [Term] id: NeXO:7733 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.437053783 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8652 ! CC: | BP: | MF: relationship: linked_to NeXO:7167 ! CC: | BP: | MF:fatty acid synthase activity [Term] id: NeXO:7732 name: CC: | BP: mitochondria-nucleus signaling pathway | MF: def: "CC_def: | BP_def: A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.58236340087474 density:1 bootstrap:0.70882244 cc_score:0.0 bp_score:0.438347 mf_score:0.0195751 relationship: child_of NeXO:8288 ! CC: | BP: extrachromosomal rDNA circle accumulation involved in replicative cell aging | MF:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [Term] id: NeXO:7731 name: CC: | BP: glutamate biosynthetic process | MF:citrate (Si)-synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. | MF_def:Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [NeXO-GO:term] namespace: NeXO comment: robustness:3.89276085080568 density:0.5 bootstrap:0.6146017 cc_score:0.0 bp_score:0.23425 mf_score:0.141676 relationship: child_of NeXO:8630 ! CC: mitochondrial isocitrate dehydrogenase complex (NAD+) | BP: isocitrate metabolic process | MF:isocitrate dehydrogenase activity [Term] id: NeXO:5813 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03822053567945 density:0.333333333333333 bootstrap:0.84116542 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6991 ! CC: | BP: | MF: relationship: linked_to NeXO:7211 ! CC: | BP: | MF: [Term] id: NeXO:7737 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.35833353185837 density:1 bootstrap:0.475740884 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8129 ! CC: | BP: | MF: [Term] id: NeXO:7734 name: CC: | BP: fatty acid biosynthetic process | MF:lipoate biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | MF_def:The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:13.7838067573356 density:1 bootstrap:0.8744107 cc_score:0.0 bp_score:0.198767 mf_score:0.154906 relationship: child_of NeXO:7861 ! CC: | BP: protein-cofactor linkage | MF: [Term] id: NeXO:6437 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.528194828 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6596 ! CC: | BP: | MF: [Term] id: NeXO:8193 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.498785072 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9140 ! CC: | BP: | MF: [Term] id: NeXO:9558 name: CC: | BP: iron ion homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.33502747518117 density:0.0579591836734694 bootstrap:0.245910374 cc_score:0.0 bp_score:0.157071 mf_score:0.0920072 relationship: child_of NeXO:9767 ! CC: | BP: | MF: [Term] id: NeXO:8190 name: CC: | BP: activation of adenylate cyclase activity by G-protein signaling pathway | MF:receptor binding def: "CC_def: | BP_def: Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP. | MF_def:Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.249503588 cc_score:0.0 bp_score:0.223599 mf_score:0.120778 relationship: child_of NeXO:8823 ! CC: internal side of plasma membrane | BP: regulation of cAMP biosynthetic process | MF: relationship: linked_to NeXO:6082 ! CC: | BP: | MF: [Term] id: NeXO:8358 name: CC: | BP: | MF:glucosaminyl-phosphotidylinositol O-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:5.28540168504319 density:1 bootstrap:0.7714727 cc_score:0.0 bp_score:0.0674572 mf_score:0.220304 relationship: child_of NeXO:8759 ! CC: | BP: | MF: relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:8359 name: CC: | BP: | MF:acetyl-CoA C-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:4.70154661271356 density:1 bootstrap:0.61044432 cc_score:0.0 bp_score:0.0 mf_score:0.178903 relationship: child_of NeXO:9263 ! CC: | BP: fatty acid oxidation | MF: [Term] id: NeXO:6434 name: CC: | BP: | MF:monocarboxylic acid transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [NeXO-GO:term] namespace: NeXO comment: robustness:5.37307433478873 density:0.244444444444444 bootstrap:0.66488687 cc_score:0.0 bp_score:0.0751972 mf_score:0.109167 relationship: child_of NeXO:7723 ! CC: | BP: | MF: [Term] id: NeXO:7794 name: CC: | BP: mitochondrial respiratory chain complex IV assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.828845143886898 density:0.0277777777777778 bootstrap:0.275552252 cc_score:0.0890028 bp_score:0.167434 mf_score:0.0 relationship: child_of NeXO:8574 ! CC: | BP: respiratory chain complex IV assembly | MF: [Term] id: NeXO:9275 name: CC: | BP: actin filament polymerization | MF: def: "CC_def: | BP_def: Assembly of actin filaments by the addition of actin monomers to a filament. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.72916464012915 density:0.857142857142857 bootstrap:0.442742139 cc_score:0.0 bp_score:0.335731 mf_score:0.0977689 relationship: child_of NeXO:9435 ! CC: | BP: actin polymerization or depolymerization | MF: [Term] id: NeXO:8350 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03944669480943 density:0.666666666666667 bootstrap:0.379051009 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8544 ! CC: | BP: | MF: relationship: linked_to NeXO:8084 ! CC: | BP: charged-tRNA amino acid modification | MF: relationship: linked_to NeXO:7474 ! CC: | BP: | MF: relationship: linked_to NeXO:7948 ! CC: | BP: | MF: [Term] id: NeXO:6433 name: CC: | BP: mitochondrial RNA catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.41837349375278 density:0.333333333333333 bootstrap:0.624283194 cc_score:0.0 bp_score:0.1701 mf_score:0.0 relationship: child_of NeXO:6578 ! CC: | BP: | MF: [Term] id: NeXO:8354 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.4417659978867 density:0.0526315789473684 bootstrap:0.278531775 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9190 ! CC: | BP: | MF: [Term] id: NeXO:8355 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32167778981601 density:0.104761904761905 bootstrap:0.329909434 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9253 ! CC: | BP: | MF: [Term] id: NeXO:8356 name: CC: TORC1 complex | BP: | MF: def: "CC_def: A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p; in mammals the complex contains orthologs of the yeast proteins. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.359610262 cc_score:0.229482 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9194 ! CC: | BP: | MF: [Term] id: NeXO:6432 name: CC: | BP: ammonium transport | MF: def: "CC_def: | BP_def: The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73757129 cc_score:0.0 bp_score:0.113767 mf_score:0.0 relationship: child_of NeXO:7513 ! CC: | BP: | MF: [Term] id: NeXO:9175 name: CC: transcriptionally active chromatin | BP: GO:2001209 | MF: def: "CC_def: The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.76673673630799 density:0.8 bootstrap:0.510847072 cc_score:0.261475 bp_score:0.528235 mf_score:0.0 relationship: child_of NeXO:9368 ! CC: Cdc73/Paf1 complex | BP: GO:2001173 | MF:TFIIF-class binding transcription factor activity relationship: linked_to NeXO:9776 ! CC: protein kinase CK2 complex | BP: regulation of transcription from RNA polymerase III promoter | MF:regulation of transcription from RNA polymerase III promoter [Term] id: NeXO:6458 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.44417233828633 density:0.133333333333333 bootstrap:0.80329622 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7086 ! CC: | BP: | MF: [Term] id: NeXO:7426 name: CC: | BP: betaine transport | MF: def: "CC_def: | BP_def: The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.42933329541386 density:0.0952380952380952 bootstrap:0.302520735 cc_score:0.0 bp_score:0.104883 mf_score:0.0 relationship: child_of NeXO:8395 ! CC: | BP: | MF: [Term] id: NeXO:7425 name: CC: | BP: telomeric 3' overhang formation | MF: def: "CC_def: | BP_def: The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06554944275248 density:0.666666666666667 bootstrap:0.8564255 cc_score:0.0 bp_score:0.231513 mf_score:0.099329 relationship: child_of NeXO:7426 ! CC: | BP: betaine transport | MF: [Term] id: NeXO:7424 name: CC: | BP: cellular age-dependent response to reactive oxygen species | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.270230814 cc_score:0.0 bp_score:0.138642 mf_score:0.0 relationship: child_of NeXO:8291 ! CC: | BP: | MF: [Term] id: NeXO:7423 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.52381787787054 density:0.0849673202614379 bootstrap:0.561457616 cc_score:0.0 bp_score:0.0440954 mf_score:0.0458828 relationship: child_of NeXO:9074 ! CC: | BP: | MF: [Term] id: NeXO:7422 name: CC: | BP: S-adenosylmethionine biosynthetic process | MF:6-phosphofructokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. | MF_def:Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54548452 cc_score:0.0 bp_score:0.221585 mf_score:0.298636 relationship: child_of NeXO:8307 ! CC: | BP: | MF:methionine adenosyltransferase activity [Term] id: NeXO:9306 name: CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.00693188819419 density:1 bootstrap:0.69232168 cc_score:0.0 bp_score:0.0387242 mf_score:0.221142 relationship: child_of NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:9204 ! CC: | BP: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | MF:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity relationship: linked_to NeXO:9347 ! CC: | BP: | MF:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [Term] id: NeXO:9816 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.1719409978775 density:0.98901098901099 bootstrap:0.42724131 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9879 ! CC: | BP: | MF: relationship: linked_to NeXO:9904 ! CC: | BP: | MF: relationship: linked_to NeXO:9817 ! CC: | BP: | MF: [Term] id: NeXO:6868 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.21722376139273 density:0.238095238095238 bootstrap:0.51021669 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7933 ! CC: | BP: | MF: [Term] id: NeXO:5706 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.475293468 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5818 ! CC: | BP: | MF: [Term] id: NeXO:7428 name: CC: | BP: error-prone translesion synthesis | MF: def: "CC_def: | BP_def: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12387030340873 density:0.666666666666667 bootstrap:0.7933514 cc_score:0.0 bp_score:0.334604 mf_score:0.0 relationship: child_of NeXO:7871 ! CC: | BP: | MF: [Term] id: NeXO:9263 name: CC: | BP: fatty acid oxidation | MF: def: "CC_def: | BP_def: The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.64662202415533 density:0.222222222222222 bootstrap:0.225117919 cc_score:0.0 bp_score:0.127024 mf_score:0.0 relationship: child_of NeXO:9705 ! CC: | BP: CVT pathway | MF: [Term] id: NeXO:5707 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.551695982 cc_score:0.0 bp_score:0.0713074 mf_score:0.0 relationship: child_of NeXO:5819 ! CC: | BP: | MF: [Term] id: NeXO:6932 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62304547100062 density:0.333333333333333 bootstrap:0.533384559 cc_score:0.0 bp_score:0.0402834 mf_score:0.0178154 relationship: child_of NeXO:7262 ! CC: | BP: | MF: [Term] id: NeXO:6600 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.94127352722579 density:0.5 bootstrap:0.63001583 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7049 ! CC: | BP: 1,6-beta-glucan metabolic process | MF: [Term] id: NeXO:6601 name: CC: | BP: | MF:malate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.421485368 cc_score:0.0 bp_score:0.0 mf_score:0.165277 relationship: child_of NeXO:7490 ! CC: | BP: | MF: [Term] id: NeXO:6602 name: CC: | BP: | MF:phosphoribosylaminoimidazole carboxylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.78712339869313 density:1 bootstrap:0.79216763 cc_score:0.0 bp_score:0.0 mf_score:0.293582 relationship: child_of NeXO:7589 ! CC: | BP: | MF:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Term] id: NeXO:6603 name: CC: | BP: | MF:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [NeXO-GO:term] namespace: NeXO comment: robustness:3.89685630188463 density:0.120879120879121 bootstrap:0.432950128 cc_score:0.0 bp_score:0.0654089 mf_score:0.169597 relationship: child_of NeXO:7423 ! CC: | BP: | MF: [Term] id: NeXO:6604 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.98513994577556 density:0.133333333333333 bootstrap:0.529900502 cc_score:0.0 bp_score:0.0895591 mf_score:0.0664861 relationship: child_of NeXO:6678 ! CC: | BP: | MF: [Term] id: NeXO:6605 name: CC: | BP: regulation of fatty acid metabolic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.427945432 cc_score:0.0 bp_score:0.11558 mf_score:0.0 relationship: child_of NeXO:6936 ! CC: | BP: | MF:phosphotransferase activity, carboxyl group as acceptor [Term] id: NeXO:6606 name: CC: | BP: telomere capping | MF: def: "CC_def: | BP_def: A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.53194962290727 density:0.333333333333333 bootstrap:0.47519081 cc_score:0.0 bp_score:0.171457 mf_score:0.0 relationship: child_of NeXO:7675 ! CC: | BP: | MF: [Term] id: NeXO:6865 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86603205042476 density:0.166666666666667 bootstrap:0.81945941 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7580 ! CC: | BP: | MF: [Term] id: NeXO:7450 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76365618 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7880 ! CC: | BP: | MF: [Term] id: NeXO:6609 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.58095076996069 density:0.2 bootstrap:0.80487884 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7760 ! CC: | BP: | MF: [Term] id: NeXO:6438 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.208855602 cc_score:0.0 bp_score:0.0 mf_score:0.0984939 relationship: child_of NeXO:6912 ! CC: | BP: | MF:carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: NeXO:5946 name: CC: | BP: | MF:basic amino acid transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78953178 cc_score:0.0 bp_score:0.0 mf_score:0.111135 relationship: child_of NeXO:6086 ! CC: | BP: sucrose catabolic process | MF:sucrose alpha-glucosidase activity [Term] id: NeXO:5947 name: CC: | BP: alanine catabolic process | MF:L-alanine:2-oxoglutarate aminotransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. | MF_def:Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.508867481 cc_score:0.0 bp_score:0.439586 mf_score:0.299528 relationship: child_of NeXO:6203 ! CC: | BP: alanine biosynthetic process | MF:L-valine transaminase activity [Term] id: NeXO:5944 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.735442151 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6589 ! CC: | BP: | MF: [Term] id: NeXO:5945 name: CC: | BP: | MF:diphthine synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.831132621 cc_score:0.0 bp_score:0.0 mf_score:0.438198 relationship: child_of NeXO:6054 ! CC: | BP: | MF: [Term] id: NeXO:5942 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8904527 cc_score:0.0 bp_score:0.0 mf_score:0.0318529 relationship: child_of NeXO:5943 ! CC: | BP: | MF: relationship: linked_to NeXO:8732 ! CC: | BP: response to hydroperoxide | MF: [Term] id: NeXO:5943 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.15599196734774 density:0.666666666666667 bootstrap:0.90770498 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6458 ! CC: | BP: | MF: [Term] id: NeXO:5940 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08830710403992 density:0.666666666666667 bootstrap:0.869188358 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6071 ! CC: | BP: | MF: [Term] id: NeXO:5941 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.758366888 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6710 ! CC: | BP: | MF: [Term] id: NeXO:5948 name: CC: | BP: glutathione catabolic process | MF:metallodipeptidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. | MF_def:Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [NeXO-GO:term] namespace: NeXO comment: robustness:2.30438374249805 density:1 bootstrap:0.87989622 cc_score:0.0 bp_score:0.442831 mf_score:0.443635 relationship: child_of NeXO:6446 ! CC: | BP: cellular modified amino acid catabolic process | MF:omega peptidase activity [Term] id: NeXO:5784 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.4687121934117 density:0.666666666666667 bootstrap:0.93158045 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7082 ! CC: site of double-strand break | BP: | MF: [Term] id: NeXO:5785 name: CC: condensed chromosome inner kinetochore | BP: | MF: def: "CC_def: The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60074551 cc_score:0.135599 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6420 ! CC: | BP: | MF: [Term] id: NeXO:5786 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.83766618907367 density:0.238095238095238 bootstrap:0.725983111 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6846 ! CC: | BP: | MF: [Term] id: NeXO:5787 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.18465931784819 density:0.666666666666667 bootstrap:0.816913005 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5788 ! CC: | BP: | MF: [Term] id: NeXO:5780 name: CC: | BP: ribosome disassembly | MF: def: "CC_def: | BP_def: The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87814437 cc_score:0.0 bp_score:0.29784 mf_score:0.0 relationship: child_of NeXO:6913 ! CC: | BP: glycosphingolipid biosynthetic process | MF: [Term] id: NeXO:5781 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71576176 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6062 ! CC: | BP: | MF: [Term] id: NeXO:5782 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23970338461711 density:1 bootstrap:0.83119488 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6168 ! CC: endoplasmic reticulum lumen | BP: cell redox homeostasis | MF:protein disulfide isomerase activity [Term] id: NeXO:5783 name: CC: | BP: | MF:eukaryotic initiation factor 4E binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86647535 cc_score:0.0 bp_score:0.0 mf_score:0.445287 relationship: child_of NeXO:6450 ! CC: | BP: establishment of mitochondrion localization | MF: [Term] id: NeXO:5788 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.99290471337425 density:0.533333333333333 bootstrap:0.90863011 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5960 ! CC: | BP: | MF: [Term] id: NeXO:5789 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62547081697754 density:0.166666666666667 bootstrap:0.62179554 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6499 ! CC: | BP: misfolded or incompletely synthesized protein catabolic process | MF: [Term] id: NeXO:9268 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.12678977122328 density:0.166666666666667 bootstrap:0.29879618 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9643 ! CC: | BP: | MF: [Term] id: NeXO:5363 name: CC: | BP: GO:0035969 | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90081775 cc_score:0.0 bp_score:0.176625 mf_score:0.0562316 relationship: child_of NeXO:5444 ! CC: | BP: positive regulation of lipid transport | MF: [Term] id: NeXO:9135 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.82484879207668 density:0.1 bootstrap:0.181763723 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9605 ! CC: | BP: | MF: [Term] id: NeXO:6118 name: CC: | BP: fatty acid beta-oxidation using acyl-CoA oxidase | MF:acyl-CoA oxidase activity def: "CC_def: | BP_def: A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). | MF_def:Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87841206 cc_score:0.0 bp_score:0.441369 mf_score:0.446685 relationship: child_of NeXO:6119 ! CC: | BP: nucleoside catabolic process | MF:bis(5'-adenosyl)-triphosphatase activity relationship: linked_to NeXO:8730 ! CC: | BP: positive regulation of lipid catabolic process | MF: [Term] id: NeXO:6119 name: CC: | BP: nucleoside catabolic process | MF:bis(5'-adenosyl)-triphosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). | MF_def:Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81648282 cc_score:0.0 bp_score:0.128547 mf_score:0.317661 relationship: child_of NeXO:6213 ! CC: peroxisomal matrix | BP: | MF:acyl-CoA dehydrogenase activity [Term] id: NeXO:9580 name: CC: pre-autophagosomal structure | BP: piecemeal microautophagy of nucleus | MF: def: "CC_def: A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. | BP_def: Degradation of a cell nucleus by microautophagy. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.30269480062725 density:0.56060606060606 bootstrap:0.47960407 cc_score:0.178486 bp_score:0.286192 mf_score:0.0 relationship: child_of NeXO:9705 ! CC: | BP: CVT pathway | MF: [Term] id: NeXO:6116 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97620197945684 density:0.333333333333333 bootstrap:0.790754596 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7227 ! CC: | BP: | MF: [Term] id: NeXO:6117 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67396628 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7172 ! CC: | BP: N-acylethanolamine metabolic process | MF: [Term] id: NeXO:6110 name: CC: | BP: zinc ion transmembrane transport | MF: def: "CC_def: | BP_def: A process in which a zinc ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70951696 cc_score:0.0 bp_score:0.203694 mf_score:0.0838235 relationship: child_of NeXO:6863 ! CC: | BP: | MF: [Term] id: NeXO:6111 name: CC: mitochondrial inner boundary membrane | BP: mitochondrial fusion | MF: def: "CC_def: The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane. | BP_def: Merging of two or more mitochondria within a cell to form a single compartment. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12838250777595 density:1 bootstrap:0.94136498 cc_score:0.175666 bp_score:0.657657 mf_score:0.0 relationship: child_of NeXO:7320 ! CC: | BP: | MF: [Term] id: NeXO:6112 name: CC: | BP: regulation of transcription from RNA polymerase II promoter during meiosis | MF: def: "CC_def: | BP_def: A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79878321056097 density:0.666666666666667 bootstrap:0.71385739 cc_score:0.0 bp_score:0.329141 mf_score:0.0 relationship: child_of NeXO:6377 ! CC: | BP: regulation of transcription during meiosis | MF: [Term] id: NeXO:5443 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79829033 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6217 ! CC: | BP: cysteine biosynthetic process via cystathionine | MF:cystathionine gamma-lyase activity [Term] id: NeXO:9149 name: CC: autophagic vacuole membrane | BP: autophagic vacuole assembly | MF: def: "CC_def: The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. | BP_def: The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.34990958945568 density:0.666666666666667 bootstrap:0.562586454 cc_score:0.13095 bp_score:0.192034 mf_score:0.0880393 relationship: child_of NeXO:9580 ! CC: pre-autophagosomal structure | BP: piecemeal microautophagy of nucleus | MF: [Term] id: NeXO:7066 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.69720881329324 density:0.194444444444444 bootstrap:0.518386241 cc_score:0.0 bp_score:0.0916896 mf_score:0.0899907 relationship: child_of NeXO:7973 ! CC: | BP: | MF: [Term] id: NeXO:5441 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8798477 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6166 ! CC: | BP: | MF: [Term] id: NeXO:7283 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73295976 cc_score:0.0 bp_score:0.0724276 mf_score:0.0990192 relationship: child_of NeXO:8283 ! CC: | BP: | MF:protein-arginine N-methyltransferase activity relationship: linked_to NeXO:8944 ! CC: Nup82 complex | BP: ncRNA export from nucleus | MF: [Term] id: NeXO:7282 name: CC: intrinsic to internal side of plasma membrane | BP: negative regulation of cAMP biosynthetic process | MF: def: "CC_def: Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75731863828429 density:1 bootstrap:0.51170879 cc_score:0.440807 bp_score:0.878465 mf_score:0.0355093 relationship: child_of NeXO:7806 ! CC: | BP: negative regulation of nucleotide metabolic process | MF: relationship: linked_to NeXO:8488 ! CC: | BP: G-protein signaling, coupled to cAMP nucleotide second messenger | MF:adenylate cyclase activity [Term] id: NeXO:7933 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.61740458065858 density:0.090909090909091 bootstrap:0.38041446 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8615 ! CC: | BP: | MF: [Term] id: NeXO:7932 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.01848346159005 density:0.1 bootstrap:0.277119117 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8538 ! CC: | BP: | MF:G-protein coupled receptor protein signaling pathway [Term] id: NeXO:7935 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6123604 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9014 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:9459 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.51882761546312 density:0.05 bootstrap:0.159915782 cc_score:0.0 bp_score:0.0421539 mf_score:0.0 relationship: child_of NeXO:9730 ! CC: | BP: | MF: [Term] id: NeXO:9108 name: CC: nucleotide-excision repair factor 1 complex | BP: gene conversion at mating-type locus, DNA repair synthesis | MF:nucleoside binding def: "CC_def: One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. | BP_def: Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus. | MF_def:Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.189490864 cc_score:0.162324 bp_score:0.232358 mf_score:0.149484 relationship: child_of NeXO:9469 ! CC: | BP: postreplication repair | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:7442 ! CC: | BP: DNA ligation involved in DNA repair | MF:DNA ligase (ATP) activity relationship: linked_to NeXO:9748 ! CC: | BP: | MF: [Term] id: NeXO:7936 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.7555369238395 density:0.153846153846154 bootstrap:0.342614043 cc_score:0.0 bp_score:0.0618665 mf_score:0.0637745 relationship: child_of NeXO:8801 ! CC: | BP: | MF: [Term] id: NeXO:9106 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.34265003285307 density:1 bootstrap:0.312478868 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9372 ! CC: | BP: | MF: [Term] id: NeXO:9107 name: CC: | BP: regulation of translational fidelity | MF: def: "CC_def: | BP_def: Any process that modulates the ability of the translational apparatus to interpret the genetic code. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.4982209733369 density:0.142857142857143 bootstrap:0.205095211 cc_score:0.0 bp_score:0.106678 mf_score:0.0 relationship: child_of NeXO:9493 ! CC: nucleoplasmic THO complex | BP: | MF: [Term] id: NeXO:9104 name: CC: | BP: | MF:histone binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [NeXO-GO:term] namespace: NeXO comment: robustness:4.76917293353427 density:0.131868131868132 bootstrap:0.580056075 cc_score:0.0 bp_score:0.0937375 mf_score:0.155775 relationship: child_of NeXO:9784 ! CC: | BP: histone modification | MF:histone H3-K4 methylation [Term] id: NeXO:7288 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.81384783521834 density:1 bootstrap:0.80338719 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7902 ! CC: | BP: | MF: [Term] id: NeXO:9102 name: CC: | BP: protein unfolding | MF: def: "CC_def: | BP_def: The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.03926069451744 density:0.166666666666667 bootstrap:0.254178173 cc_score:0.0 bp_score:0.13536 mf_score:0.0 relationship: child_of NeXO:9396 ! CC: | BP: | MF: relationship: linked_to NeXO:7969 ! CC: mitochondrial outer membrane translocase complex | BP: outer mitochondrial membrane organization | MF: relationship: linked_to NeXO:7408 ! CC: | BP: | MF: [Term] id: NeXO:9451 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.968774638175 density:0.666666666666667 bootstrap:0.353235995 cc_score:0.0 bp_score:0.0267057 mf_score:0.0 relationship: child_of NeXO:9687 ! CC: | BP: | MF: relationship: linked_to NeXO:5151 ! CC: | BP: | MF: [Term] id: NeXO:9100 name: CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: def: "CC_def: | BP_def: Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.02858638186808 density:0.7 bootstrap:0.43319599 cc_score:0.0 bp_score:0.107665 mf_score:0.0 relationship: child_of NeXO:9633 ! CC: | BP: | MF: [Term] id: NeXO:9101 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.231478248 cc_score:0.0 bp_score:0.0 mf_score:0.0679572 relationship: child_of NeXO:9680 ! CC: | BP: | MF: [Term] id: NeXO:9142 name: CC: | BP: glycogen metabolic process | MF:protein phosphatase regulator activity def: "CC_def: | BP_def: The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. | MF_def:Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:6.38362347330909 density:0.0978260869565217 bootstrap:0.524779118 cc_score:0.0 bp_score:0.149715 mf_score:0.264963 relationship: child_of NeXO:9747 ! CC: | BP: energy reserve metabolic process | MF:phosphatase regulator activity [Term] id: NeXO:7061 name: CC: | BP: glycerol-3-phosphate catabolic process | MF:glycerol-1-phosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. | MF_def:Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.781424304 cc_score:0.0 bp_score:0.302535 mf_score:0.292472 relationship: child_of NeXO:7564 ! CC: | BP: glycerol metabolic process | MF: [Term] id: NeXO:9239 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66785362199257 density:1 bootstrap:0.460932904 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9539 ! CC: | BP: | MF: relationship: linked_to NeXO:9500 ! CC: | BP: | MF: relationship: linked_to NeXO:9286 ! CC: | BP: | MF: relationship: linked_to NeXO:8983 ! CC: | BP: | MF: relationship: linked_to NeXO:9235 ! CC: | BP: | MF: relationship: linked_to NeXO:9484 ! CC: | BP: | MF: [Term] id: NeXO:9143 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.1617600952187 density:0.0430769230769231 bootstrap:0.157405607 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9646 ! CC: | BP: | MF: [Term] id: NeXO:7060 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.66721613245334 density:0.333333333333333 bootstrap:0.75936629 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7628 ! CC: | BP: | MF: [Term] id: NeXO:7977 name: CC: | BP: | MF:ubiquitin activating enzyme activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.255199348 cc_score:0.0 bp_score:0.0 mf_score:0.272738 relationship: child_of NeXO:8524 ! CC: | BP: | MF:glycerol-3-phosphate dehydrogenase [NAD+] activity [Term] id: NeXO:7976 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20413940760081 density:0.166666666666667 bootstrap:0.341226529 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8706 ! CC: | BP: regulation of mitotic recombination | MF:NAD-dependent histone deacetylase activity [Term] id: NeXO:9146 name: CC: | BP: glycoprotein biosynthetic process | MF:mannosyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. | MF_def:Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [NeXO-GO:term] namespace: NeXO comment: robustness:3.33914157582076 density:0.087719298245614 bootstrap:0.263682429 cc_score:0.0 bp_score:0.104671 mf_score:0.146776 relationship: child_of NeXO:9722 ! CC: | BP: | MF: [Term] id: NeXO:10024 name: CC: ribonucleoprotein complex | BP: ribonucleoprotein complex biogenesis | MF:structural molecule activity def: "CC_def: A macromolecular complex containing both protein and RNA molecules. | BP_def: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. | MF_def:The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [NeXO-GO:term] namespace: NeXO comment: robustness:16.3443411440031 density:0.0476002666892038 bootstrap:0.364314043 cc_score:0.222959 bp_score:0.253468 mf_score:0.194489 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:6028 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73510859713438 density:1 bootstrap:0.77055678 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6747 ! CC: | BP: | MF: [Term] id: NeXO:9839 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.0286884329198 density:0.586666666666667 bootstrap:0.443271023 cc_score:0.0 bp_score:0.0597063 mf_score:0.0 relationship: child_of NeXO:9963 ! CC: Golgi membrane | BP: | MF: [Term] id: NeXO:7973 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39590337544628 density:0.0897435897435897 bootstrap:0.277316227 cc_score:0.0 bp_score:0.0578854 mf_score:0.0585292 relationship: child_of NeXO:8502 ! CC: | BP: | MF: [Term] id: NeXO:6021 name: CC: | BP: regulation of synaptonemal complex assembly | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.03057053423397 density:0.666666666666667 bootstrap:0.83699282 cc_score:0.0 bp_score:0.31438 mf_score:0.0 relationship: child_of NeXO:6022 ! CC: | BP: | MF:3-hydroxyacyl-CoA dehydrogenase activity [Term] id: NeXO:6022 name: CC: | BP: | MF:3-hydroxyacyl-CoA dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.56621933131507 density:0.333333333333333 bootstrap:0.70294677 cc_score:0.0 bp_score:0.0740868 mf_score:0.25111 relationship: child_of NeXO:6734 ! CC: | BP: | MF: [Term] id: NeXO:6023 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.821755403 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6807 ! CC: | BP: | MF: [Term] id: NeXO:6024 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72839748 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6749 ! CC: | BP: | MF: [Term] id: NeXO:6025 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.562317792 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6218 ! CC: | BP: | MF: [Term] id: NeXO:6026 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.97418719031549 density:1 bootstrap:0.87235814 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6460 ! CC: TORC2 complex | BP: | MF: [Term] id: NeXO:6027 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72736669 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6187 ! CC: | BP: | MF:ferrous iron binding [Term] id: NeXO:5160 name: CC: | BP: | MF:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87796209 cc_score:0.0 bp_score:0.0 mf_score:0.148788 relationship: child_of NeXO:5161 ! CC: | BP: ubiquinone biosynthetic process | MF:hexaprenyldihydroxybenzoate methyltransferase activity [Term] id: NeXO:5161 name: CC: | BP: ubiquinone biosynthetic process | MF:hexaprenyldihydroxybenzoate methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.09910649496061 density:0.666666666666667 bootstrap:0.875277854 cc_score:0.0496942 bp_score:0.187189 mf_score:0.313152 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:5162 name: CC: | BP: formate catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88935008 cc_score:0.0 bp_score:0.161771 mf_score:0.0 relationship: child_of NeXO:7230 ! CC: | BP: | MF: [Term] id: NeXO:5163 name: CC: | BP: | MF:intramolecular lyase activity def: "CC_def: | BP_def: | MF_def:The catalysis of certain rearrangements of a molecule to break or form a ring." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89271478 cc_score:0.0 bp_score:0.0 mf_score:0.220008 relationship: child_of NeXO:5391 ! CC: | BP: | MF: [Term] id: NeXO:5164 name: CC: | BP: pantothenate transmembrane transport | MF:pantothenate transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of pantothenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. | MF_def:Enables the directed movement of pantothenate across a membrane into, out of or within a cell, or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81072049 cc_score:0.0 bp_score:0.21407 mf_score:0.214689 relationship: child_of NeXO:5700 ! CC: | BP: | MF: [Term] id: NeXO:5165 name: CC: | BP: | MF:mannosylphosphate transferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a mannosylphosphate group from one compound to another." [NeXO-GO:term] namespace: NeXO comment: robustness:2.22463040581003 density:1 bootstrap:0.82004481 cc_score:0.0 bp_score:0.0 mf_score:0.43763 relationship: child_of NeXO:5166 ! CC: | BP: | MF: [Term] id: NeXO:5166 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.12150338248643 density:0.333333333333333 bootstrap:0.91131081 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7164 ! CC: | BP: | MF: [Term] id: NeXO:5167 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88639498 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5414 ! CC: | BP: | MF: [Term] id: NeXO:10004 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.2839001738316 density:0.8994708994709 bootstrap:0.455909622 cc_score:0.0 bp_score:0.0147407 mf_score:0.0 relationship: child_of NeXO:10005 ! CC: cytosolic large ribosomal subunit | BP: | MF: [Term] id: NeXO:5169 name: CC: | BP: glutaminyl-tRNA aminoacylation | MF:glutamine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.09464492097915 density:0.0181818181818182 bootstrap:0.572870629 cc_score:0.0 bp_score:0.136239 mf_score:0.135768 relationship: child_of NeXO:5178 ! CC: | BP: | MF:D-arabinose 1-dehydrogenase [NAD(P)+] activity [Term] id: NeXO:9218 name: CC: | BP: protein import into peroxisome matrix | MF: def: "CC_def: | BP_def: The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:22.843546594861 density:1 bootstrap:0.72031747 cc_score:0.0 bp_score:0.313161 mf_score:0.0 relationship: child_of NeXO:9436 ! CC: peroxisomal membrane | BP: protein targeting to peroxisome | MF: [Term] id: NeXO:9219 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.37240499591587 density:0.107142857142857 bootstrap:0.187307979 cc_score:0.0 bp_score:0.0126815 mf_score:0.0 relationship: child_of NeXO:9442 ! CC: guanyl-nucleotide exchange factor complex | BP: | MF: [Term] id: NeXO:9212 name: CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: def: "CC_def: The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. | BP_def: The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.53323628585674 density:1 bootstrap:0.62686912 cc_score:0.570992 bp_score:0.298676 mf_score:0.0 relationship: child_of NeXO:9608 ! CC: proteasome core complex | BP: proteasomal ubiquitin-independent protein catabolic process | MF:threonine-type endopeptidase activity relationship: linked_to NeXO:9604 ! CC: | BP: | MF: relationship: linked_to NeXO:8598 ! CC: proteasome regulatory particle, lid subcomplex | BP: | MF: [Term] id: NeXO:9213 name: CC: | BP: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:cyclin-dependent protein kinase inhibitor activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. | MF_def:Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:2.8643441674434 density:1 bootstrap:0.453156881 cc_score:0.0 bp_score:0.294427 mf_score:0.179445 relationship: child_of NeXO:9622 ! CC: | BP: positive regulation of spindle pole body separation | MF: relationship: linked_to NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding [Term] id: NeXO:9210 name: CC: | BP: histone monoubiquitination | MF:ATP-dependent 5'-3' DNA helicase activity def: "CC_def: | BP_def: The modification of histones by addition of a single ubiquitin group. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [NeXO-GO:term] namespace: NeXO comment: robustness:1.91459898463116 density:1 bootstrap:0.607403787 cc_score:0.0 bp_score:0.294622 mf_score:0.220341 relationship: child_of NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: relationship: linked_to NeXO:8236 ! CC: | BP: histone ubiquitination | MF: relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:7104 ! CC: core TFIIH complex | BP: nucleotide-excision repair, DNA incision | MF: relationship: linked_to NeXO:9180 ! CC: nucleotide-excision repair factor 4 complex | BP: nucleotide-excision repair, DNA damage recognition | MF: relationship: linked_to NeXO:8578 ! CC: TFIIK complex | BP: | MF: relationship: linked_to NeXO:7428 ! CC: | BP: error-prone translesion synthesis | MF: [Term] id: NeXO:9211 name: CC: proteasome regulatory particle, base subcomplex | BP: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | MF: def: "CC_def: The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. | BP_def: Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.24234688469182 density:1 bootstrap:0.45536799 cc_score:0.311029 bp_score:0.204383 mf_score:0.0 relationship: child_of NeXO:9628 ! CC: proteasome regulatory particle | BP: proteasome regulatory particle assembly | MF: relationship: linked_to NeXO:9212 ! CC: proteasome core complex, alpha-subunit complex | BP: proteasome core complex assembly | MF: [Term] id: NeXO:9216 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.11873612843766 density:0.166666666666667 bootstrap:0.294540199 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9530 ! CC: | BP: | MF: [Term] id: NeXO:9214 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.35626030327375 density:0.8 bootstrap:0.286191787 cc_score:0.0 bp_score:0.0822964 mf_score:0.0 relationship: child_of NeXO:9411 ! CC: CMG complex | BP: S phase of mitotic cell cycle | MF:DNA replication origin binding relationship: linked_to NeXO:9549 ! CC: replication fork protection complex | BP: replication fork protection | MF: [Term] id: NeXO:9215 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.63734797792412 density:0.181818181818182 bootstrap:0.363964933 cc_score:0.0 bp_score:0.0401814 mf_score:0.0 relationship: child_of NeXO:9636 ! CC: | BP: regulation of protein polymerization | MF: [Term] id: NeXO:5417 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.04258256401367 density:0.833333333333333 bootstrap:0.89579256 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6375 ! CC: | BP: | MF: [Term] id: NeXO:9234 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.02668540347873 density:0.025 bootstrap:0.182736973 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9730 ! CC: | BP: | MF: [Term] id: NeXO:6335 name: CC: | BP: error-free translesion synthesis | MF:deoxycytidyl transferase activity def: "CC_def: | BP_def: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. | MF_def:Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.17695602060401 density:1 bootstrap:0.78527389 cc_score:0.0 bp_score:0.201862 mf_score:0.438641 relationship: child_of NeXO:7428 ! CC: | BP: error-prone translesion synthesis | MF: relationship: linked_to NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: [Term] id: NeXO:6336 name: CC: | BP: cellular cadmium ion homeostasis | MF:solute:hydrogen symporter activity def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53354817 cc_score:0.0 bp_score:0.439445 mf_score:0.130461 relationship: child_of NeXO:6337 ! CC: | BP: cadmium ion transport | MF: [Term] id: NeXO:6337 name: CC: | BP: cadmium ion transport | MF: def: "CC_def: | BP_def: The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76660693268168 density:0.333333333333333 bootstrap:0.63191538 cc_score:0.0 bp_score:0.161516 mf_score:0.0 relationship: child_of NeXO:6695 ! CC: | BP: | MF: [Term] id: NeXO:6330 name: CC: Elongator holoenzyme complex | BP: | MF: def: "CC_def: A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01753878655081 density:1 bootstrap:0.674474651 cc_score:0.291765 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7369 ! CC: | BP: | MF: relationship: linked_to NeXO:6028 ! CC: | BP: | MF: relationship: linked_to NeXO:6107 ! CC: | BP: protein urmylation | MF: [Term] id: NeXO:6331 name: CC: | BP: long-chain fatty-acyl-CoA metabolic process | MF:long-chain fatty acid-CoA ligase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18. | MF_def:Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [NeXO-GO:term] namespace: NeXO comment: robustness:1.98955378316175 density:1 bootstrap:0.65589333 cc_score:0.0 bp_score:0.907453 mf_score:0.457661 relationship: child_of NeXO:7340 ! CC: | BP: acyl-CoA metabolic process | MF:long-chain fatty acid transport [Term] id: NeXO:9698 name: CC: | BP: leading strand elongation | MF: def: "CC_def: | BP_def: The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.99384845934773 density:0.080952380952381 bootstrap:0.193565021 cc_score:0.0 bp_score:0.183101 mf_score:0.0615628 relationship: child_of NeXO:9951 ! CC: replication fork | BP: DNA-dependent DNA replication | MF:structure-specific DNA binding [Term] id: NeXO:6333 name: CC: CVT complex | BP: | MF: def: "CC_def: A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84583278 cc_score:0.29171 bp_score:0.0783854 mf_score:0.0 relationship: child_of NeXO:6334 ! CC: | BP: | MF: [Term] id: NeXO:9696 name: CC: | BP: NLS-bearing substrate import into nucleus | MF: def: "CC_def: | BP_def: The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.0717554371634 density:0.571428571428571 bootstrap:0.464540531 cc_score:0.0 bp_score:0.192486 mf_score:0.0 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport relationship: linked_to NeXO:9552 ! CC: nuclear membrane | BP: nuclear pore organization | MF: relationship: linked_to NeXO:9461 ! CC: | BP: | MF: relationship: linked_to NeXO:9912 ! CC: | BP: protein desumoylation | MF: relationship: linked_to NeXO:9416 ! CC: | BP: ribosomal protein import into nucleus | MF:protein export from nucleus [Term] id: NeXO:9697 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.0889478614517 density:0.854545454545454 bootstrap:0.467937255 cc_score:0.0 bp_score:0.0277569 mf_score:0.0 relationship: child_of NeXO:9779 ! CC: | BP: | MF: [Term] id: NeXO:9694 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.8330865506517 density:0.911111111111111 bootstrap:0.69913243 cc_score:0.0854743 bp_score:0.0731792 mf_score:0.0814806 relationship: child_of NeXO:9963 ! CC: Golgi membrane | BP: | MF: relationship: linked_to NeXO:9839 ! CC: | BP: | MF: relationship: linked_to NeXO:9718 ! CC: Golgi-associated vesicle membrane | BP: retrograde vesicle-mediated transport, Golgi to ER | MF: relationship: linked_to NeXO:9811 ! CC: | BP: | MF: [Term] id: NeXO:9695 name: CC: | BP: protein insertion into membrane | MF: def: "CC_def: | BP_def: The process that results in the incorporation of a protein into a biological membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.21324491839174 density:0.638888888888889 bootstrap:0.443636487 cc_score:0.0 bp_score:0.130726 mf_score:0.0 relationship: child_of NeXO:9839 ! CC: | BP: | MF: relationship: linked_to NeXO:9627 ! CC: | BP: | MF: [Term] id: NeXO:6338 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09786273973664 density:1 bootstrap:0.729249241 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6418 ! CC: | BP: | MF: [Term] id: NeXO:6339 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.452556264 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6802 ! CC: | BP: | MF: [Term] id: NeXO:9690 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.78308289596498 density:0.0689655172413793 bootstrap:0.109817764 cc_score:0.0 bp_score:0.0414397 mf_score:0.0 relationship: child_of NeXO:9903 ! CC: | BP: microautophagy | MF: [Term] id: NeXO:9581 name: CC: U1 snRNP | BP: | MF: def: "CC_def: A ribonucleoprotein complex that contains small nuclear RNA U1. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.5248293137628 density:0.828571428571429 bootstrap:0.502771033 cc_score:0.603539 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9582 ! CC: U2-type prespliceosome | BP: spliceosome assembly | MF: [Term] id: NeXO:9076 name: CC: | BP: negative regulation of Rho protein signal transduction | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.8325162328409 density:1 bootstrap:0.556438931 cc_score:0.0 bp_score:0.294104 mf_score:0.0 relationship: child_of NeXO:9523 ! CC: | BP: | MF:cyclin binding relationship: linked_to NeXO:9351 ! CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity relationship: linked_to NeXO:8825 ! CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding [Term] id: NeXO:9077 name: CC: | BP: activation of Rho GTPase activity | MF:protein kinase C activity def: "CC_def: | BP_def: Any process that initiates the activity of an inactive GTPase of the Rho family through the replacement of GDP by GTP. | MF_def:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:3.67391691406241 density:1 bootstrap:0.74551578 cc_score:0.0 bp_score:0.294694 mf_score:0.292634 relationship: child_of NeXO:9376 ! CC: | BP: regulation of fungal-type cell wall organization | MF: relationship: linked_to NeXO:9272 ! CC: | BP: | MF: relationship: linked_to NeXO:7262 ! CC: | BP: | MF: [Term] id: NeXO:9074 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.71350258489759 density:0.04 bootstrap:0.27519442 cc_score:0.0 bp_score:0.0482884 mf_score:0.0338786 relationship: child_of NeXO:9390 ! CC: | BP: | MF: [Term] id: NeXO:9075 name: CC: microtubule organizing center part | BP: | MF: def: "CC_def: Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.42079868714518 density:0.141025641025641 bootstrap:0.317540164 cc_score:0.179991 bp_score:0.07885 mf_score:0.0 relationship: child_of NeXO:9743 ! CC: | BP: | MF: [Term] id: NeXO:9072 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.374393614 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9251 ! CC: | BP: | MF: relationship: linked_to NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:8674 ! CC: | BP: | MF: relationship: linked_to NeXO:9916 ! CC: polysomal ribosome | BP: | MF: [Term] id: NeXO:9073 name: CC: Rpd3S complex | BP: histone H3 deacetylation | MF:NAD-dependent histone deacetylase activity (H3-K14 specific) def: "CC_def: A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species). | BP_def: The modification of histone H3 by the removal of one or more acetyl groups. | MF_def:Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.9859471222392 density:1 bootstrap:0.65351748 cc_score:0.365978 bp_score:0.441963 mf_score:0.128122 relationship: child_of NeXO:9624 ! CC: | BP: negative regulation of transcription during meiosis | MF: relationship: linked_to NeXO:8219 ! CC: | BP: negative regulation of transcription from RNA polymerase I promoter | MF: relationship: linked_to NeXO:5477 ! CC: | BP: | MF: relationship: linked_to NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:5754 ! CC: | BP: | MF: relationship: linked_to NeXO:9546 ! CC: | BP: antisense RNA metabolic process | MF:DNA topoisomerase activity relationship: linked_to NeXO:8520 ! CC: | BP: | MF: [Term] id: NeXO:9071 name: CC: GET complex | BP: protein insertion into ER membrane | MF:protein anchor def: "CC_def: A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins. | BP_def: The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. | MF_def:Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [NeXO-GO:term] namespace: NeXO comment: robustness:3.5481505093732 density:1 bootstrap:0.69534806 cc_score:0.437864 bp_score:0.29516 mf_score:0.146002 relationship: child_of NeXO:9418 ! CC: | BP: inter-Golgi cisterna vesicle-mediated transport | MF: relationship: linked_to NeXO:9651 ! CC: | BP: detoxification of arsenic-containing substance | MF: relationship: linked_to NeXO:9592 ! CC: peripheral to membrane of membrane fraction | BP: vesicle fusion with Golgi apparatus | MF:syntaxin binding [Term] id: NeXO:9079 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.660102889 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9357 ! CC: | BP: positive regulation of transposition, RNA-mediated | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding relationship: linked_to NeXO:9475 ! CC: F-actin capping protein complex | BP: barbed-end actin filament capping | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:7971 ! CC: | BP: | MF: relationship: linked_to NeXO:8547 ! CC: | BP: | MF: [Term] id: NeXO:9674 name: CC: | BP: glycolysis | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Glycolysis begins with phosphorylation of a monosaccharide (generally glucose) on the sixth carbon by a hexokinase, and ends with the production of pyruvate. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.2733260132449 density:0.438095238095238 bootstrap:0.50653965 cc_score:0.0 bp_score:0.188861 mf_score:0.0730598 relationship: child_of NeXO:9870 ! CC: | BP: glucose catabolic process | MF: [Term] id: NeXO:9675 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.71666494886019 density:0.0232558139534884 bootstrap:0.093707744 cc_score:0.0 bp_score:0.0295992 mf_score:0.0 relationship: child_of NeXO:9877 ! CC: | BP: | MF: [Term] id: NeXO:9676 name: CC: NuA3 histone acetyltransferase complex | BP: promoter clearance from RNA polymerase II promoter | MF:RNA polymerase II core promoter sequence-specific DNA binding def: "CC_def: A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p. | BP_def: Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. | MF_def:Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery." [NeXO-GO:term] namespace: NeXO comment: robustness:2.17001283299709 density:1 bootstrap:0.78027277 cc_score:0.15966 bp_score:0.178547 mf_score:0.29792 relationship: child_of NeXO:9988 ! CC: DNA-directed RNA polymerase II, holoenzyme | BP: RNA polymerase II transcriptional preinitiation complex assembly | MF:RNA polymerase II transcriptional preinitiation complex assembly relationship: linked_to NeXO:7571 ! CC: | BP: | MF: relationship: linked_to NeXO:9508 ! CC: | BP: | MF:ATP-dependent 3'-5' DNA helicase activity relationship: linked_to NeXO:8370 ! CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding relationship: linked_to NeXO:8876 ! CC: | BP: chromatin remodeling at centromere | MF: relationship: linked_to NeXO:7215 ! CC: | BP: nicotinamide riboside biosynthetic process | MF: relationship: linked_to NeXO:9559 ! CC: | BP: | MF:RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly relationship: linked_to NeXO:8661 ! CC: | BP: | MF: relationship: linked_to NeXO:6221 ! CC: | BP: | MF: relationship: linked_to NeXO:8557 ! CC: | BP: | MF:transcription from RNA polymerase III promoter [Term] id: NeXO:9677 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.672555959091 density:0.955555555555556 bootstrap:0.6356551 cc_score:0.0 bp_score:0.0661144 mf_score:0.0 relationship: child_of NeXO:9772 ! CC: DNA-directed RNA polymerase II, core complex | BP: | MF:RNA-directed RNA polymerase activity [Term] id: NeXO:9670 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.43725232165248 density:0.41025641025641 bootstrap:0.498395942 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10003 ! CC: cytosolic small ribosomal subunit | BP: | MF: relationship: linked_to NeXO:9787 ! CC: | BP: | MF: [Term] id: NeXO:9671 name: CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: def: "CC_def: | BP_def: The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.99809580352794 density:0.357142857142857 bootstrap:0.36328251 cc_score:0.0 bp_score:0.109731 mf_score:0.0 relationship: child_of NeXO:9912 ! CC: | BP: protein desumoylation | MF: [Term] id: NeXO:9672 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.12982240707502 density:0.833333333333333 bootstrap:0.3450967 cc_score:0.0 bp_score:0.0568745 mf_score:0.0 relationship: child_of NeXO:9825 ! CC: | BP: | MF: relationship: linked_to NeXO:7566 ! CC: | BP: | MF: relationship: linked_to NeXO:8958 ! CC: | BP: | MF:protein complex scaffold relationship: linked_to NeXO:8915 ! CC: | BP: | MF:histone acetyltransferase activity [Term] id: NeXO:9673 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69041489890835 density:0.0178947368421053 bootstrap:0.117623382 cc_score:0.022564 bp_score:0.0447061 mf_score:0.0 relationship: child_of NeXO:9900 ! CC: | BP: | MF: [Term] id: NeXO:6842 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.80890478132646 density:0.666666666666667 bootstrap:0.71902994 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8007 ! CC: | BP: | MF: [Term] id: NeXO:6965 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.42859702322161 density:0.1 bootstrap:0.545227818 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7646 ! CC: | BP: peptidyl-histidine modification | MF: [Term] id: NeXO:9678 name: CC: DNA-directed RNA polymerase I complex | BP: | MF: def: "CC_def: RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.4519169873477 density:0.588235294117647 bootstrap:0.688285273 cc_score:0.327158 bp_score:0.09981 mf_score:0.0 relationship: child_of NeXO:9911 ! CC: nuclear DNA-directed RNA polymerase complex | BP: transcription from RNA polymerase III promoter | MF:DNA-directed RNA polymerase activity [Term] id: NeXO:8629 name: CC: | BP: amino acid transmembrane transport | MF:amino acid transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [NeXO-GO:term] namespace: NeXO comment: robustness:7.10294923895107 density:0.377777777777778 bootstrap:0.67328456 cc_score:0.0 bp_score:0.174713 mf_score:0.130451 relationship: child_of NeXO:9566 ! CC: | BP: | MF:phosphatidylinositol bisphosphate phosphatase activity [Term] id: NeXO:8419 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17323880042212 density:0.3 bootstrap:0.354305335 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8919 ! CC: Doa10p ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:8158 name: CC: | BP: meiotic sister chromatid cohesion, centromeric | MF: def: "CC_def: | BP_def: The cell cycle process in which centromeres of sister chromatids are joined during meiosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8621263 cc_score:0.0 bp_score:0.441025 mf_score:0.0 relationship: child_of NeXO:8758 ! CC: | BP: | MF: relationship: linked_to NeXO:8189 ! CC: | BP: mitotic cell cycle spindle assembly checkpoint | MF: [Term] id: NeXO:6966 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61039078 cc_score:0.0 bp_score:0.0878765 mf_score:0.0 relationship: child_of NeXO:8211 ! CC: | BP: | MF: [Term] id: NeXO:9236 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.33084005560344 density:0.142857142857143 bootstrap:0.161828684 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9763 ! CC: | BP: | MF: [Term] id: NeXO:8624 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.64558931122941 density:0.0285412262156448 bootstrap:0.295358416 cc_score:0.0 bp_score:0.0339741 mf_score:0.052577 relationship: child_of NeXO:9453 ! CC: | BP: | MF: [Term] id: NeXO:7951 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.470471878 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8096 ! CC: | BP: | MF: [Term] id: NeXO:8908 name: CC: | BP: | MF:rRNA primary transcript binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.763233249 cc_score:0.0 bp_score:0.0 mf_score:0.176011 relationship: child_of NeXO:9139 ! CC: | BP: | MF: relationship: linked_to NeXO:8947 ! CC: PeBoW complex | BP: | MF: [Term] id: NeXO:8625 name: CC: extrinsic to vacuolar membrane | BP: | MF: def: "CC_def: Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.12804245204954 density:0.214285714285714 bootstrap:0.727725974 cc_score:0.245417 bp_score:0.093286 mf_score:0.0 relationship: child_of NeXO:9563 ! CC: Seh1-associated complex | BP: | MF: [Term] id: NeXO:8905 name: CC: | BP: iron ion transport | MF:iron ion transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:7.13236979773271 density:0.275 bootstrap:0.387426443 cc_score:0.0 bp_score:0.308441 mf_score:0.221719 relationship: child_of NeXO:9558 ! CC: | BP: iron ion homeostasis | MF: [Term] id: NeXO:9461 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.3789796241013 density:0.844444444444444 bootstrap:0.50875283 cc_score:0.082741 bp_score:0.0930987 mf_score:0.0 relationship: child_of NeXO:9552 ! CC: nuclear membrane | BP: nuclear pore organization | MF: [Term] id: NeXO:8906 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.53697249395048 density:0.0445632798573975 bootstrap:0.238645993 cc_score:0.0 bp_score:0.0478236 mf_score:0.0 relationship: child_of NeXO:9558 ! CC: | BP: iron ion homeostasis | MF: [Term] id: NeXO:8901 name: CC: | BP: ergosterol biosynthetic process | MF:monooxygenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. | MF_def:Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [NeXO-GO:term] namespace: NeXO comment: robustness:18.4341280516304 density:0.791208791208791 bootstrap:0.87064225 cc_score:0.0 bp_score:0.385268 mf_score:0.146728 relationship: child_of NeXO:9378 ! CC: | BP: ergosterol metabolic process | MF: [Term] id: NeXO:8900 name: CC: | BP: | MF:acid-ammonia (or amide) ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:6.08048278292355 density:0.666666666666667 bootstrap:0.706182107 cc_score:0.0 bp_score:0.0481405 mf_score:0.101034 relationship: child_of NeXO:9378 ! CC: | BP: ergosterol metabolic process | MF: [Term] id: NeXO:9460 name: CC: | BP: gene conversion at mating-type locus, DNA double-strand break processing | MF:endodeoxyribonuclease activity def: "CC_def: | BP_def: The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang. | MF_def:Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [NeXO-GO:term] namespace: NeXO comment: robustness:6.81936189258744 density:0.642857142857143 bootstrap:0.504005944 cc_score:0.0 bp_score:0.180263 mf_score:0.119028 relationship: child_of NeXO:9715 ! CC: | BP: double-strand break repair via homologous recombination | MF:DNA metabolic process [Term] id: NeXO:10025 name: CC: cytoskeleton | BP: mitotic cell cycle | MF:cell cycle def: "CC_def: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. | BP_def: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. | MF_def:The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [NeXO-GO:term] namespace: NeXO comment: robustness:13.134303278178 density:0.0314221155204067 bootstrap:0.235263826 cc_score:0.142889 bp_score:0.209127 mf_score:0.150918 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:8152 name: CC: Cul8-RING ubiquitin ligase complex | BP: replication fork processing | MF:H3 histone acetyltransferase activity def: "CC_def: A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins. | BP_def: The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted. | MF_def:Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [NeXO-GO:term] namespace: NeXO comment: robustness:5.68516895501778 density:1 bootstrap:0.89258856 cc_score:0.528222 bp_score:0.530585 mf_score:0.176364 relationship: child_of NeXO:9495 ! CC: | BP: negative regulation of transposition, RNA-mediated | MF: [Term] id: NeXO:9237 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.757179489 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9501 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: [Term] id: NeXO:6063 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92210255615649 density:0.333333333333333 bootstrap:0.74805267 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6064 ! CC: | BP: | MF: [Term] id: NeXO:8153 name: CC: | BP: regulation of ubiquitin homeostasis | MF:Y-form DNA binding def: "CC_def: | BP_def: Any process that modulates the rate, frequency, or extent of ubiquitin homeostasis. Ubiquitin homeostasis is any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell. | MF_def:Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.478783355 cc_score:0.0 bp_score:0.133481 mf_score:0.222268 relationship: child_of NeXO:8747 ! CC: | BP: error-free postreplication DNA repair | MF:four-way junction DNA binding [Term] id: NeXO:6848 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.01091688586048 density:1 bootstrap:0.670054439 cc_score:0.0 bp_score:0.0 mf_score:0.08095 relationship: child_of NeXO:7532 ! CC: | BP: | MF: relationship: linked_to NeXO:7088 ! CC: | BP: | MF: [Term] id: NeXO:6849 name: CC: intrinsic to vacuolar membrane | BP: | MF:polyphosphate kinase activity def: "CC_def: Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. | BP_def: | MF_def:Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63188377 cc_score:0.219276 bp_score:0.0 mf_score:0.439293 relationship: child_of NeXO:7761 ! CC: | BP: | MF: [Term] id: NeXO:7126 name: CC: | BP: | MF:phosphatidylserine decarboxylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6324483 cc_score:0.0 bp_score:0.0462926 mf_score:0.2936 relationship: child_of NeXO:8084 ! CC: | BP: charged-tRNA amino acid modification | MF: [Term] id: NeXO:6843 name: CC: | BP: mating | MF: def: "CC_def: | BP_def: The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.492189498 cc_score:0.0 bp_score:0.292573 mf_score:0.0 relationship: child_of NeXO:7546 ! CC: | BP: | MF:Sar GTPase activator activity relationship: linked_to NeXO:8298 ! CC: COPII vesicle coat | BP: regulation of COPII vesicle coating | MF: [Term] id: NeXO:6840 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.56988731466013 density:1 bootstrap:0.40837468 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7095 ! CC: | BP: | MF: [Term] id: NeXO:6841 name: CC: | BP: | MF:3-oxoacyl-[acyl-carrier-protein] synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [NeXO-GO:term] namespace: NeXO comment: robustness:4.10668282404742 density:1 bootstrap:0.465743592 cc_score:0.0 bp_score:0.0 mf_score:0.197683 relationship: child_of NeXO:7167 ! CC: | BP: | MF:fatty acid synthase activity [Term] id: NeXO:6846 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.20646288116205 density:0.115384615384615 bootstrap:0.62007735 cc_score:0.0 bp_score:0.0362148 mf_score:0.0 relationship: child_of NeXO:7652 ! CC: | BP: | MF: [Term] id: NeXO:6847 name: CC: | BP: | MF:G-protein beta/gamma-subunit complex binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79546522 cc_score:0.0 bp_score:0.0376129 mf_score:0.179301 relationship: child_of NeXO:7932 ! CC: | BP: | MF: [Term] id: NeXO:7120 name: CC: | BP: | MF:tRNA guanylyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.864197207 cc_score:0.0 bp_score:0.0 mf_score:0.452393 relationship: child_of NeXO:8012 ! CC: | BP: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase | MF:deoxyhypusine synthase activity relationship: linked_to NeXO:8206 ! CC: | BP: | MF:biotin synthase activity [Term] id: NeXO:7121 name: CC: | BP: regulation of membrane potential | MF:3'(2'),5'-bisphosphate nucleotidase activity def: "CC_def: | BP_def: Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. | MF_def:Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.829646084 cc_score:0.0 bp_score:0.438099 mf_score:0.446759 relationship: child_of NeXO:7940 ! CC: | BP: | MF: [Term] id: NeXO:5308 name: CC: | BP: bile acid and bile salt transport | MF:bile acid-exporting ATPase activity def: "CC_def: | BP_def: The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85111121 cc_score:0.0 bp_score:0.440591 mf_score:0.458 relationship: child_of NeXO:6007 ! CC: | BP: antimonite transport | MF:bile acid transmembrane transporter activity [Term] id: NeXO:5309 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.908030861 cc_score:0.0 bp_score:0.0 mf_score:0.0126376 relationship: child_of NeXO:5437 ! CC: | BP: pyrimidine nucleotide transport | MF:pyrimidine nucleotide transmembrane transporter activity [Term] id: NeXO:6306 name: CC: heterogeneous nuclear ribonucleoprotein complex | BP: regulation of mRNA stability | MF: def: "CC_def: Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA. | BP_def: Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84160265 cc_score:0.291758 bp_score:0.102716 mf_score:0.0 relationship: child_of NeXO:6682 ! CC: | BP: | MF: [Term] id: NeXO:9833 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.37329805795203 density:0.581818181818182 bootstrap:0.555970708 cc_score:0.078313 bp_score:0.0439601 mf_score:0.0 relationship: child_of NeXO:10014 ! CC: | BP: positive regulation of transcription elongation, DNA-dependent | MF: [Term] id: NeXO:9230 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33821434712447 density:0.666666666666667 bootstrap:0.25504936 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9326 ! CC: | BP: cellular amide catabolic process | MF:nucleobase:cation symporter activity relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:5301 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.96966643 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5959 ! CC: | BP: | MF: [Term] id: NeXO:5302 name: CC: | BP: thiamine pyrophosphate transport | MF:thiamine pyrophosphate transport def: "CC_def: | BP_def: The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92853283 cc_score:0.0 bp_score:0.443465 mf_score:0.4375 relationship: child_of NeXO:5438 ! CC: | BP: thiamine transport | MF:thiamine transmembrane transporter activity [Term] id: NeXO:5304 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69131184 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5370 ! CC: | BP: fatty acid transport | MF:fatty acid transport [Term] id: NeXO:5306 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89195514 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5448 ! CC: | BP: | MF: [Term] id: NeXO:5307 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.806344873 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6527 ! CC: | BP: | MF: [Term] id: NeXO:6590 name: CC: | BP: | MF:ferrochelatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.729993632 cc_score:0.0 bp_score:0.0 mf_score:0.199226 relationship: child_of NeXO:7294 ! CC: | BP: | MF: [Term] id: NeXO:6591 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60771038 cc_score:0.0 bp_score:0.0242598 mf_score:0.0341415 relationship: child_of NeXO:7005 ! CC: | BP: tryptophan transport | MF:L-tryptophan transmembrane transporter activity [Term] id: NeXO:6592 name: CC: | BP: valyl-tRNA aminoacylation | MF:valine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.603582855 cc_score:0.0 bp_score:0.316059 mf_score:0.314598 relationship: child_of NeXO:7829 ! CC: | BP: tyrosyl-tRNA aminoacylation | MF:tyrosine-tRNA ligase activity [Term] id: NeXO:8230 name: CC: | BP: dTDP biosynthetic process | MF:uridylate kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). | MF_def:Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.300975728 cc_score:0.0 bp_score:0.168514 mf_score:0.139339 relationship: child_of NeXO:9576 ! CC: DNA replication preinitiation complex | BP: double-strand break repair via break-induced replication | MF: [Term] id: NeXO:6594 name: CC: | BP: cytosine transport | MF:cytosine transport def: "CC_def: | BP_def: The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:2.66105932781242 density:0.4 bootstrap:0.376568623 cc_score:0.0 bp_score:0.173416 mf_score:0.16803 relationship: child_of NeXO:7066 ! CC: | BP: | MF: [Term] id: NeXO:6595 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.509692298 cc_score:0.0 bp_score:0.0 mf_score:0.0685326 relationship: child_of NeXO:7072 ! CC: | BP: | MF: [Term] id: NeXO:6596 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.36928326996423 density:0.4 bootstrap:0.603684558 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6597 ! CC: | BP: | MF: [Term] id: NeXO:6597 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.081605234899 density:0.138888888888889 bootstrap:0.54585022 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8052 ! CC: | BP: | MF: [Term] id: NeXO:6599 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.75504483545751 density:0.2 bootstrap:0.63218635 cc_score:0.0 bp_score:0.0793827 mf_score:0.0 relationship: child_of NeXO:7657 ! CC: | BP: | MF: [Term] id: NeXO:8239 name: CC: ESCRT I complex | BP: regulation of transcription from RNA polymerase II promoter by glucose | MF: def: "CC_def: An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. | BP_def: Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.05224729026787 density:1 bootstrap:0.824073701 cc_score:0.246452 bp_score:0.134266 mf_score:0.0 relationship: child_of NeXO:8597 ! CC: | BP: | MF: [Term] id: NeXO:8238 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.202194503 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9042 ! CC: | BP: branched chain family amino acid biosynthetic process | MF: [Term] id: NeXO:5414 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.836128606 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6071 ! CC: | BP: | MF: [Term] id: NeXO:5818 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62302528 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7176 ! CC: | BP: | MF: [Term] id: NeXO:5416 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88002053 cc_score:0.0 bp_score:0.0979678 mf_score:0.0996085 relationship: child_of NeXO:6413 ! CC: | BP: | MF: [Term] id: NeXO:7639 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28306534882574 density:0.142857142857143 bootstrap:0.476256 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8306 ! CC: | BP: | MF: [Term] id: NeXO:5410 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.839029 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6960 ! CC: | BP: | MF: [Term] id: NeXO:5411 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87460935 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5784 ! CC: | BP: | MF: [Term] id: NeXO:5412 name: CC: | BP: | MF:nucleotide phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.730389381 cc_score:0.0 bp_score:0.0 mf_score:0.118123 relationship: child_of NeXO:5490 ! CC: | BP: | MF: [Term] id: NeXO:5413 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86013068 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6186 ! CC: | BP: | MF: [Term] id: NeXO:7632 name: CC: | BP: pyruvate transport | MF: def: "CC_def: | BP_def: The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7439966662942 density:0.3 bootstrap:0.228167662 cc_score:0.0 bp_score:0.136097 mf_score:0.0 relationship: child_of NeXO:8528 ! CC: | BP: | MF: [Term] id: NeXO:7633 name: CC: | BP: regulation of phospholipid translocation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.341148719317 density:0.666666666666667 bootstrap:0.49949477 cc_score:0.0 bp_score:0.204457 mf_score:0.0 relationship: child_of NeXO:8422 ! CC: | BP: | MF: [Term] id: NeXO:5418 name: CC: | BP: GO:2001196 | MF:holo-[acyl-carrier-protein] synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86184883 cc_score:0.0 bp_score:0.441262 mf_score:0.221892 relationship: child_of NeXO:5983 ! CC: | BP: positive regulation of cellular amino acid metabolic process | MF:acetyl-CoA:L-glutamate N-acetyltransferase activity [Term] id: NeXO:7637 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.79347712635473 density:0.333333333333333 bootstrap:0.65128451 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8516 ! CC: | BP: | MF: [Term] id: NeXO:7634 name: CC: Smc5-Smc6 complex | BP: rDNA separation | MF: def: "CC_def: A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. | BP_def: The cell cycle process in which rDNA repeat regions are physically detached from each other during chromosome separation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.81344312352893 density:0.464285714285714 bootstrap:0.76037445 cc_score:0.768348 bp_score:0.23994 mf_score:0.0 relationship: child_of NeXO:8025 ! CC: | BP: resolution of recombination intermediates | MF: [Term] id: NeXO:8786 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75934666302214 density:0.2 bootstrap:0.374001989 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9361 ! CC: | BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:7221 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.84526224577526 density:1 bootstrap:0.816676591 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8445 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity [Term] id: NeXO:5791 name: CC: | BP: | MF:ethanolaminephosphotransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.70564882214754 density:0.333333333333333 bootstrap:0.781407813 cc_score:0.0 bp_score:0.0 mf_score:0.255911 relationship: child_of NeXO:5990 ! CC: | BP: | MF: [Term] id: NeXO:5790 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.0455779881886 density:0.666666666666667 bootstrap:0.84530296 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5791 ! CC: | BP: | MF:ethanolaminephosphotransferase activity [Term] id: NeXO:5779 name: CC: | BP: homocysteine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.810111195 cc_score:0.0 bp_score:0.113247 mf_score:0.0 relationship: child_of NeXO:8232 ! CC: | BP: cytoplasmic sequestering of protein | MF: relationship: linked_to NeXO:9508 ! CC: | BP: | MF:ATP-dependent 3'-5' DNA helicase activity [Term] id: NeXO:6933 name: CC: | BP: mitochondrion migration along actin filament | MF: def: "CC_def: | BP_def: The directed movement of a mitochondrion along a microfilament, mediated by motor proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77584934 cc_score:0.0 bp_score:0.443717 mf_score:0.0 relationship: child_of NeXO:7717 ! CC: | BP: actin filament-based movement | MF: relationship: linked_to NeXO:9475 ! CC: F-actin capping protein complex | BP: barbed-end actin filament capping | MF: [Term] id: NeXO:9841 name: CC: | BP: response to acid | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.7799617241655 density:0.933333333333333 bootstrap:0.476365762 cc_score:0.0 bp_score:0.227174 mf_score:0.0 relationship: child_of NeXO:9913 ! CC: | BP: | MF: [Term] id: NeXO:6931 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31179384054996 density:1 bootstrap:0.8855642 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7883 ! CC: inner plaque of spindle pole body | BP: | MF: [Term] id: NeXO:6936 name: CC: | BP: | MF:phosphotransferase activity, carboxyl group as acceptor def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.24705975542947 density:0.0666666666666667 bootstrap:0.46510342 cc_score:0.0 bp_score:0.0 mf_score:0.179172 relationship: child_of NeXO:7507 ! CC: | BP: | MF: [Term] id: NeXO:9846 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.85473120429333 density:0.0735632183908046 bootstrap:0.098916309 cc_score:0.0 bp_score:0.0543436 mf_score:0.0 relationship: child_of NeXO:9934 ! CC: | BP: | MF: [Term] id: NeXO:6934 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.91858987408667 density:0.333333333333333 bootstrap:0.745321005 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7085 ! CC: EGO complex | BP: | MF:phosphatidylinositol-3,4-bisphosphate binding relationship: linked_to NeXO:8626 ! CC: GSE complex | BP: | MF: [Term] id: NeXO:6935 name: CC: | BP: premeiotic DNA replication | MF: def: "CC_def: | BP_def: The replication of DNA that precedes meiotic cell division. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.507829723 cc_score:0.0 bp_score:0.125301 mf_score:0.0 relationship: child_of NeXO:7739 ! CC: | BP: | MF: [Term] id: NeXO:8127 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.40295637 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8890 ! CC: | BP: GMP metabolic process | MF: [Term] id: NeXO:8126 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.39531594736323 density:0.123809523809524 bootstrap:0.503716668 cc_score:0.0 bp_score:0.0585764 mf_score:0.0867248 relationship: child_of NeXO:8895 ! CC: | BP: | MF: [Term] id: NeXO:8697 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.418173188 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9121 ! CC: mitotic checkpoint complex | BP: | MF: relationship: linked_to NeXO:9668 ! CC: | BP: microtubule depolymerization | MF: relationship: linked_to NeXO:9152 ! CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: [Term] id: NeXO:6939 name: CC: | BP: ammonia assimilation cycle | MF:glutamate synthase (NADH) activity def: "CC_def: | BP_def: The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. | MF_def:Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:2.09569582572064 density:1 bootstrap:0.727743514 cc_score:0.0 bp_score:0.441094 mf_score:0.449596 relationship: child_of NeXO:7600 ! CC: | BP: | MF:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:8691 name: CC: | BP: glutamate metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32291326058268 density:0.114285714285714 bootstrap:0.295073065 cc_score:0.0 bp_score:0.14131 mf_score:0.0852101 relationship: child_of NeXO:9345 ! CC: | BP: tricarboxylic acid cycle | MF: [Term] id: NeXO:8122 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.32768203021399 density:0.333333333333333 bootstrap:0.356916988 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9348 ! CC: | BP: | MF: [Term] id: NeXO:8121 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.96523719663936 density:0.833333333333333 bootstrap:0.553910705 cc_score:0.0 bp_score:0.0797958 mf_score:0.0 relationship: child_of NeXO:8664 ! CC: COPI vesicle coat | BP: | MF: [Term] id: NeXO:5776 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82562224 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7533 ! CC: | BP: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: [Term] id: NeXO:7705 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76587399 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8208 ! CC: | BP: | MF: relationship: linked_to NeXO:6554 ! CC: | BP: | MF: relationship: linked_to NeXO:9351 ! CC: | BP: activation of MAPKKK activity | MF:MAP kinase kinase kinase kinase activity [Term] id: NeXO:7702 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.12347496702234 density:0.0555555555555556 bootstrap:0.222278259 cc_score:0.0 bp_score:0.0245834 mf_score:0.0 relationship: child_of NeXO:8462 ! CC: | BP: | MF: [Term] id: NeXO:7703 name: CC: septin cytoskeleton | BP: | MF: def: "CC_def: The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.13414031026804 density:0.2 bootstrap:0.550322167 cc_score:0.11041 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8860 ! CC: | BP: protein sumoylation | MF: [Term] id: NeXO:5579 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84188162 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7462 ! CC: | BP: mitochondrial aspartyl-tRNA aminoacylation | MF:aspartate-tRNA ligase activity [Term] id: NeXO:5578 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.844987935 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6756 ! CC: | BP: | MF: [Term] id: NeXO:5577 name: CC: | BP: pyridoxal phosphate biosynthetic process | MF:pyridoxal phosphate biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. | MF_def:The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [NeXO-GO:term] namespace: NeXO comment: robustness:3.67980618005918 density:1 bootstrap:0.74790781 cc_score:0.0 bp_score:0.197938 mf_score:0.191795 relationship: child_of NeXO:5763 ! CC: | BP: | MF: [Term] id: NeXO:5575 name: CC: | BP: thiamine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70891971 cc_score:0.0 bp_score:0.110013 mf_score:0.0 relationship: child_of NeXO:5764 ! CC: | BP: pyridoxine biosynthetic process | MF: relationship: linked_to NeXO:5577 ! CC: | BP: pyridoxal phosphate biosynthetic process | MF:pyridoxal phosphate biosynthetic process [Term] id: NeXO:5574 name: CC: | BP: | MF:uracil DNA N-glycosylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.823633203 cc_score:0.0 bp_score:0.0 mf_score:0.445819 relationship: child_of NeXO:6095 ! CC: | BP: | MF: [Term] id: NeXO:5573 name: CC: | BP: positive regulation of phosphatase activity | MF: def: "CC_def: | BP_def: Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74659299 cc_score:0.0 bp_score:0.294376 mf_score:0.0 relationship: child_of NeXO:6739 ! CC: Golgi trans cisterna | BP: | MF:oxysterol binding [Term] id: NeXO:5572 name: CC: | BP: | MF:pre-mRNA branch point binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35833902763162 density:1 bootstrap:0.92158272 cc_score:0.0 bp_score:0.0 mf_score:0.296067 relationship: child_of NeXO:6762 ! CC: | BP: | MF: [Term] id: NeXO:5571 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.597642707 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5754 ! CC: | BP: | MF: [Term] id: NeXO:5570 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68987835863823 density:0.333333333333333 bootstrap:0.578215798 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5708 ! CC: | BP: | MF: [Term] id: NeXO:7615 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.30744577461161 density:0.333333333333333 bootstrap:0.346119794 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7936 ! CC: | BP: | MF: [Term] id: NeXO:5346 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89480519 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6165 ! CC: | BP: | MF: [Term] id: NeXO:9317 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03186163935603 density:0.3 bootstrap:0.309707023 cc_score:0.0 bp_score:0.0667778 mf_score:0.0 relationship: child_of NeXO:9660 ! CC: | BP: | MF: [Term] id: NeXO:8349 name: CC: | BP: | MF:protein geranylgeranyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.5803745193748 density:0.333333333333333 bootstrap:0.50570716 cc_score:0.0 bp_score:0.0 mf_score:0.117625 relationship: child_of NeXO:9135 ! CC: | BP: | MF: [Term] id: NeXO:10034 name: CC: cell part | BP: cellular process | MF:binding def: "CC_def: Any constituent part of a cell, the basic structural and functional unit of all organisms. | BP_def: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. | MF_def:The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:12.8627052162266 density:0.00241277987004925 bootstrap:0.89790929 cc_score:0.590834 bp_score:0.57058 mf_score:0.383423 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:8343 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.0199285897475 density:0.681818181818182 bootstrap:0.43158269 cc_score:0.0 bp_score:0.066452 mf_score:0.0449753 relationship: child_of NeXO:8364 ! CC: | BP: | MF: [Term] id: NeXO:9835 name: CC: spindle pole body | BP: microtubule nucleation | MF:structural constituent of cytoskeleton def: "CC_def: The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. | BP_def: The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. | MF_def:The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [NeXO-GO:term] namespace: NeXO comment: robustness:6.55958217165789 density:0.286764705882353 bootstrap:0.274579364 cc_score:0.125042 bp_score:0.279963 mf_score:0.235631 relationship: child_of NeXO:9919 ! CC: condensed chromosome kinetochore | BP: sister chromatid segregation | MF: [Term] id: NeXO:8341 name: CC: | BP: minus-end-directed microtubule motor activity | MF:minus-end-directed microtubule motor activity def: "CC_def: | BP_def: Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP). | MF_def:Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.684365728 cc_score:0.0 bp_score:0.21875 mf_score:0.222787 relationship: child_of NeXO:8984 ! CC: tubulin complex | BP: nuclear migration involved in conjugation with cellular fusion | MF: relationship: linked_to NeXO:8418 ! CC: | BP: cellular response to misfolded protein | MF: relationship: linked_to NeXO:9152 ! CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: [Term] id: NeXO:8340 name: CC: Ric1p-Rgp1p complex | BP: | MF: def: "CC_def: A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.644015853 cc_score:0.230112 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9222 ! CC: | BP: | MF: [Term] id: NeXO:8347 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.14840027747063 density:0.333333333333333 bootstrap:0.267033435 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9253 ! CC: | BP: | MF: relationship: linked_to NeXO:6829 ! CC: | BP: | MF: [Term] id: NeXO:8346 name: CC: Piccolo NuA4 histone acetyltransferase complex | BP: | MF:H4 histone acetyltransferase activity def: "CC_def: A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. | BP_def: | MF_def:Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [NeXO-GO:term] namespace: NeXO comment: robustness:5.45852043349714 density:1 bootstrap:0.8228382 cc_score:0.421219 bp_score:0.0 mf_score:0.22602 relationship: child_of NeXO:8915 ! CC: | BP: | MF:histone acetyltransferase activity [Term] id: NeXO:8345 name: CC: | BP: allantoin catabolic process | MF:urea carboxylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. | MF_def:Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.31360467802695 density:0.5 bootstrap:0.354140893 cc_score:0.0 bp_score:0.186849 mf_score:0.199355 relationship: child_of NeXO:8884 ! CC: | BP: | MF: [Term] id: NeXO:5178 name: CC: | BP: | MF:D-arabinose 1-dehydrogenase [NAD(P)+] activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.16713029502308 density:0.0151515151515152 bootstrap:0.708665719 cc_score:0.0 bp_score:0.0311025 mf_score:0.101119 relationship: child_of NeXO:5189 ! CC: | BP: | MF: [Term] id: NeXO:9314 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.12636158129994 density:0.8 bootstrap:0.590836131 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9506 ! CC: | BP: | MF: relationship: linked_to NeXO:9768 ! CC: | BP: | MF: [Term] id: NeXO:9164 name: CC: | BP: rDNA condensation | MF:rDNA binding def: "CC_def: | BP_def: The cell cycle process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase. | MF_def:Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:5.72151262381829 density:0.571428571428571 bootstrap:0.54695192 cc_score:0.0 bp_score:0.315364 mf_score:0.160329 relationship: child_of NeXO:9680 ! CC: | BP: | MF: [Term] id: NeXO:9640 name: CC: protein phosphatase type 2A complex | BP: mitotic cell cycle checkpoint | MF: def: "CC_def: A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. | BP_def: A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.2051083447876 density:0.6 bootstrap:0.633394366 cc_score:0.3517 bp_score:0.103213 mf_score:0.0796509 relationship: child_of NeXO:9739 ! CC: | BP: regulation of growth of unicellular organism as a thread of attached cells | MF: [Term] id: NeXO:7412 name: CC: | BP: cellular response to hypoxia | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.06702036377167 density:0.5 bootstrap:0.670858618 cc_score:0.0 bp_score:0.120823 mf_score:0.0 relationship: child_of NeXO:7638 ! CC: | BP: regulation of translation in response to stress | MF: [Term] id: NeXO:7413 name: CC: | BP: | MF:tRNA (guanosine-2'-O-)-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.31764479 cc_score:0.0 bp_score:0.0 mf_score:0.44291 relationship: child_of NeXO:7699 ! CC: | BP: L-serine catabolic process | MF:L-threonine ammonia-lyase activity relationship: linked_to NeXO:9567 ! CC: | BP: | MF: [Term] id: NeXO:7410 name: CC: | BP: | MF:nitric oxide reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.428502823 cc_score:0.0 bp_score:0.0241179 mf_score:0.319184 relationship: child_of NeXO:8229 ! CC: | BP: | MF:nitric oxide dioxygenase activity [Term] id: NeXO:7198 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52050026070125 density:0.133333333333333 bootstrap:0.31087448 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7901 ! CC: | BP: | MF: [Term] id: NeXO:7416 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.54989416515292 density:0.6 bootstrap:0.67235568 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8485 ! CC: | BP: | MF: [Term] id: NeXO:9311 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.26401238162896 density:0.2 bootstrap:0.193051742 cc_score:0.0 bp_score:0.0397052 mf_score:0.0 relationship: child_of NeXO:9655 ! CC: | BP: | MF: [Term] id: NeXO:7415 name: CC: | BP: negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:centromere-specific nucleosome binding def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. | MF_def:Interacting selectively and non-covalently with a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.217008446 cc_score:0.0 bp_score:0.195035 mf_score:0.252066 relationship: child_of NeXO:8269 ! CC: | BP: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF: [Term] id: NeXO:7418 name: CC: | BP: manganese ion transport | MF:manganese ion transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56618341 cc_score:0.0 bp_score:0.110534 mf_score:0.176468 relationship: child_of NeXO:7938 ! CC: | BP: regulation of phosphate transport | MF: relationship: linked_to NeXO:8851 ! CC: | BP: cellular response to phosphate starvation | MF: relationship: linked_to NeXO:5991 ! CC: | BP: phosphate transport | MF:phosphate transmembrane transporter activity [Term] id: NeXO:7419 name: CC: | BP: | MF:SUMO ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function." [NeXO-GO:term] namespace: NeXO comment: robustness:2.85538966695042 density:0.666666666666667 bootstrap:0.74302548 cc_score:0.0 bp_score:0.0 mf_score:0.483221 relationship: child_of NeXO:7703 ! CC: septin cytoskeleton | BP: | MF: [Term] id: NeXO:8956 name: CC: | BP: termination of RNA polymerase II transcription, exosome-dependent | MF: def: "CC_def: | BP_def: The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.85291877705805 density:1 bootstrap:0.65038514 cc_score:0.0 bp_score:0.230566 mf_score:0.0604884 relationship: child_of NeXO:9407 ! CC: mRNA cleavage and polyadenylation specificity factor complex | BP: termination of RNA polymerase II transcription | MF: relationship: linked_to NeXO:7737 ! CC: | BP: | MF: relationship: linked_to NeXO:9364 ! CC: | BP: | MF: [Term] id: NeXO:8957 name: CC: | BP: protein heterodimerization activity | MF: def: "CC_def: | BP_def: Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.91707587343392 density:1 bootstrap:0.6676954 cc_score:0.0 bp_score:0.175 mf_score:0.0 relationship: child_of NeXO:9364 ! CC: | BP: | MF: [Term] id: NeXO:5133 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85802648 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5206 ! CC: | BP: | MF: [Term] id: NeXO:8954 name: CC: | BP: regulation of transposition, RNA-mediated | MF:positive regulation of signal transduction def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. | MF_def:Any process that activates or increases the frequency, rate or extent of signal transduction." [NeXO-GO:term] namespace: NeXO comment: robustness:4.8149666621687 density:1 bootstrap:0.64025228 cc_score:0.0 bp_score:0.269786 mf_score:0.11266 relationship: child_of NeXO:9341 ! CC: heterotrimeric G-protein complex | BP: osmosensory signaling pathway via Sho1 osmosensor | MF:protein domain specific binding relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity relationship: linked_to NeXO:9789 ! CC: | BP: regulation of exit from mitosis | MF:histone serine kinase activity [Term] id: NeXO:6613 name: CC: | BP: mitochondria-associated protein catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.28012432617045 density:1 bootstrap:0.86146751 cc_score:0.0 bp_score:0.219654 mf_score:0.0 relationship: child_of NeXO:7079 ! CC: | BP: | MF: [Term] id: NeXO:5088 name: CC: | BP: histidyl-tRNA aminoacylation | MF:histidine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70837156 cc_score:0.0 bp_score:0.213747 mf_score:0.213593 relationship: child_of NeXO:5091 ! CC: | BP: | MF: [Term] id: NeXO:6617 name: CC: NatC complex | BP: | MF: def: "CC_def: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.6644793 cc_score:0.224033 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7615 ! CC: | BP: | MF: [Term] id: NeXO:6616 name: CC: | BP: proline metabolic process | MF:pyrroline-5-carboxylate reductase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52890201 cc_score:0.0 bp_score:0.191186 mf_score:0.441451 relationship: child_of NeXO:7443 ! CC: | BP: | MF:glutamate-5-semialdehyde dehydrogenase activity [Term] id: NeXO:6615 name: CC: | BP: D-gluconate metabolic process | MF:gluconokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. | MF_def:Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88575296 cc_score:0.0 bp_score:0.43792 mf_score:0.437674 relationship: child_of NeXO:7194 ! CC: | BP: | MF: [Term] id: NeXO:6614 name: CC: Cdc48p-Npl4p-Ufd1p AAA ATPase complex | BP: cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process | MF:polyubiquitin binding def: "CC_def: A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. | BP_def: The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation. | MF_def:Interacting selectively and non-covalently with a polymer of ubiqutin." [NeXO-GO:term] namespace: NeXO comment: robustness:2.37735732737927 density:1 bootstrap:0.93650645 cc_score:0.583519 bp_score:0.442399 mf_score:0.587151 relationship: child_of NeXO:8418 ! CC: | BP: cellular response to misfolded protein | MF: relationship: linked_to NeXO:7280 ! CC: Hrd1p ubiquitin ligase ERAD-L complex | BP: | MF: relationship: linked_to NeXO:7079 ! CC: | BP: | MF: relationship: linked_to NeXO:9162 ! CC: DNA polymerase complex | BP: cellular response to cold | MF:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: NeXO:5773 name: CC: | BP: | MF:lipid phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.78997296339477 density:0.166666666666667 bootstrap:0.75401883 cc_score:0.0 bp_score:0.0837305 mf_score:0.109869 relationship: child_of NeXO:6830 ! CC: | BP: | MF: [Term] id: NeXO:6619 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.65571667559962 density:0.1 bootstrap:0.73237004 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8452 ! CC: | BP: coenzyme A metabolic process | MF:protein phosphatase inhibitor activity [Term] id: NeXO:5951 name: CC: | BP: positive regulation of translation in response to stress | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.743825656 cc_score:0.0 bp_score:0.179044 mf_score:0.0 relationship: child_of NeXO:6451 ! CC: | BP: | MF: [Term] id: NeXO:5950 name: CC: | BP: response to xenobiotic stimulus | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.61848559 cc_score:0.0 bp_score:0.114888 mf_score:0.0 relationship: child_of NeXO:6204 ! CC: | BP: | MF:palmitoyl-CoA hydrolase activity [Term] id: NeXO:5953 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.14873646363524 density:0.666666666666667 bootstrap:0.90353622 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6051 ! CC: | BP: | MF: [Term] id: NeXO:5952 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85244564 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5953 ! CC: | BP: | MF: [Term] id: NeXO:5955 name: CC: | BP: siroheme biosynthetic process | MF:sirohydrochlorin ferrochelatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings. | MF_def:Catalysis of the reaction: siroheme OK = Fe(2+) + sirohydrochlorin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86169878 cc_score:0.0 bp_score:0.293563 mf_score:0.451419 relationship: child_of NeXO:5956 ! CC: | BP: | MF:precorrin-2 dehydrogenase activity [Term] id: NeXO:5954 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67994709 cc_score:0.0 bp_score:0.0718807 mf_score:0.0 relationship: child_of NeXO:6195 ! CC: | BP: | MF: [Term] id: NeXO:5957 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.27897633229206 density:0.285714285714286 bootstrap:0.722565891 cc_score:0.0 bp_score:0.0583078 mf_score:0.0928208 relationship: child_of NeXO:6421 ! CC: | BP: | MF: [Term] id: NeXO:5956 name: CC: | BP: | MF:precorrin-2 dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [NeXO-GO:term] namespace: NeXO comment: robustness:3.08063289366939 density:0.666666666666667 bootstrap:0.86487399 cc_score:0.0 bp_score:0.0 mf_score:0.203418 relationship: child_of NeXO:5957 ! CC: | BP: | MF: [Term] id: NeXO:5959 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.42283292825476 density:0.666666666666667 bootstrap:0.91254999 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5960 ! CC: | BP: | MF: [Term] id: NeXO:5958 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78907704 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5959 ! CC: | BP: | MF: [Term] id: NeXO:9693 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.73481739466782 density:0.0661375661375661 bootstrap:0.120360595 cc_score:0.0 bp_score:0.020734 mf_score:0.0 relationship: child_of NeXO:9880 ! CC: | BP: | MF: [Term] id: NeXO:5797 name: CC: cell wall-bounded periplasmic space | BP: asparagine catabolic process | MF:asparaginase activity def: "CC_def: The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria. | BP_def: The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid. | MF_def:Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:3.94963484816597 density:1 bootstrap:0.86161266 cc_score:0.304029 bp_score:0.532349 mf_score:0.529396 relationship: child_of NeXO:5798 ! CC: periplasmic space | BP: cellular response to nitrogen starvation | MF: [Term] id: NeXO:7373 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.6870579289347 density:0.238095238095238 bootstrap:0.355914912 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7884 ! CC: | BP: | MF: [Term] id: NeXO:5795 name: CC: | BP: | MF:hydrolase activity, acting on ether bonds def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [NeXO-GO:term] namespace: NeXO comment: robustness:2.01266221468373 density:0.333333333333333 bootstrap:0.820202052 cc_score:0.0 bp_score:0.0 mf_score:0.160717 relationship: child_of NeXO:6171 ! CC: | BP: | MF: [Term] id: NeXO:5794 name: CC: | BP: nicotinic acid riboside biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.66878214662364 density:0.166666666666667 bootstrap:0.65537299 cc_score:0.0 bp_score:0.160568 mf_score:0.0 relationship: child_of NeXO:7108 ! CC: | BP: | MF: [Term] id: NeXO:5793 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.07117744031268 density:0.0277777777777778 bootstrap:0.460235384 cc_score:0.0 bp_score:0.0485755 mf_score:0.0580538 relationship: child_of NeXO:6193 ! CC: | BP: | MF: [Term] id: NeXO:5792 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.34318383617527 density:0.8 bootstrap:0.424096804 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6140 ! CC: | BP: | MF: [Term] id: NeXO:5772 name: CC: | BP: dolichol biosynthetic process | MF:dehydrodolichyl diphosphate synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units. | MF_def:Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.99814105653948 density:1 bootstrap:0.661567457 cc_score:0.0 bp_score:0.224402 mf_score:0.881682 relationship: child_of NeXO:5773 ! CC: | BP: | MF:lipid phosphatase activity [Term] id: NeXO:8896 name: CC: | BP: phosphatidylinositol dephosphorylation | MF:phosphatidylinositol-4-phosphate phosphatase activity def: "CC_def: | BP_def: The process of removing one or more phosphate groups from a phosphatidylinositol. | MF_def:Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.9107873853604 density:1 bootstrap:0.66598865 cc_score:0.0950585 bp_score:0.502817 mf_score:0.65625 relationship: child_of NeXO:9298 ! CC: | BP: | MF:phosphatidylinositol phosphate 5-phosphatase activity [Term] id: NeXO:8895 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.353454887728 density:0.150197628458498 bootstrap:0.430925343 cc_score:0.0 bp_score:0.0664208 mf_score:0.0519518 relationship: child_of NeXO:9345 ! CC: | BP: tricarboxylic acid cycle | MF: [Term] id: NeXO:5799 name: CC: | BP: asparagine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.09060855395188 density:0.266666666666667 bootstrap:0.563784034 cc_score:0.0 bp_score:0.199613 mf_score:0.0 relationship: child_of NeXO:7784 ! CC: | BP: aspartate family amino acid catabolic process | MF: [Term] id: NeXO:5798 name: CC: periplasmic space | BP: cellular response to nitrogen starvation | MF: def: "CC_def: The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi). | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56527936597976 density:0.4 bootstrap:0.67596179 cc_score:0.179994 bp_score:0.287206 mf_score:0.0 relationship: child_of NeXO:5799 ! CC: | BP: asparagine metabolic process | MF: [Term] id: NeXO:7370 name: CC: transcription export complex 2 | BP: | MF: def: "CC_def: A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54450279 cc_score:0.175043 bp_score:0.0309205 mf_score:0.0 relationship: child_of NeXO:8137 ! CC: | BP: uracil metabolic process | MF: [Term] id: NeXO:8893 name: CC: | BP: regulation of translational termination | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of translational termination. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.256223725 cc_score:0.0 bp_score:0.152388 mf_score:0.0 relationship: child_of NeXO:9324 ! CC: | BP: chaperone cofactor-dependent protein refolding | MF: relationship: linked_to NeXO:7625 ! CC: | BP: | MF: relationship: linked_to NeXO:9450 ! CC: | BP: deadenylation-dependent decapping of nuclear-transcribed mRNA | MF:m7G(5')pppN diphosphatase activity [Term] id: NeXO:8892 name: CC: | BP: membrane addition at site of cytokinesis | MF: def: "CC_def: | BP_def: Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90148269172749 density:0.666666666666667 bootstrap:0.767207621 cc_score:0.0 bp_score:0.229729 mf_score:0.0 relationship: child_of NeXO:9522 ! CC: | BP: | MF: [Term] id: NeXO:5775 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22979272335669 density:1 bootstrap:0.8238551 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7148 ! CC: | BP: | MF:sterol binding [Term] id: NeXO:8958 name: CC: | BP: | MF:protein complex scaffold def: "CC_def: | BP_def: | MF_def:Functions to provide a physical support for the assembly of a multiprotein complex." [NeXO-GO:term] namespace: NeXO comment: robustness:7.38781760552109 density:1 bootstrap:0.90436411 cc_score:0.0 bp_score:0.0683602 mf_score:0.196181 relationship: child_of NeXO:9801 ! CC: SAGA-type complex | BP: internal peptidyl-lysine acetylation | MF:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity relationship: linked_to NeXO:9132 ! CC: transcription factor TFIID complex | BP: | MF:sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly relationship: linked_to NeXO:8118 ! CC: | BP: | MF: relationship: linked_to NeXO:7780 ! CC: | BP: | MF: relationship: linked_to NeXO:8638 ! CC: | BP: | MF: [Term] id: NeXO:8890 name: CC: | BP: GMP metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving GMP, guanosine monophosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15816823169292 density:0.138888888888889 bootstrap:0.267725707 cc_score:0.0 bp_score:0.126468 mf_score:0.0 relationship: child_of NeXO:9590 ! CC: | BP: | MF: [Term] id: NeXO:10032 name: CC: intracellular | BP: metabolic process | MF:catalytic activity def: "CC_def: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. | BP_def: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. | MF_def:Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [NeXO-GO:term] namespace: NeXO comment: robustness:21.9385922554384 density:0.0056036926486159 bootstrap:0.65638491 cc_score:0.391193 bp_score:0.346248 mf_score:0.243951 relationship: child_of NeXO:10034 ! CC: cell part | BP: cellular process | MF:binding [Term] id: NeXO:6109 name: CC: | BP: negative regulation of DNA replication | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82816075693041 density:1 bootstrap:0.80942854 cc_score:0.0 bp_score:0.103124 mf_score:0.0 relationship: child_of NeXO:7710 ! CC: | BP: deoxyribonucleotide biosynthetic process | MF:oxidoreductase activity, acting on CH or CH2 groups relationship: linked_to NeXO:9571 ! CC: | BP: DNA damage induced protein phosphorylation | MF:histone phosphorylation [Term] id: NeXO:9691 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.93761933707009 density:0.277777777777778 bootstrap:0.377663548 cc_score:0.0822803 bp_score:0.0189414 mf_score:0.0 relationship: child_of NeXO:9838 ! CC: | BP: | MF: [Term] id: NeXO:6107 name: CC: | BP: protein urmylation | MF: def: "CC_def: | BP_def: Covalent attachment of the ubiquitin-like protein URM1 to another protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.23329694364615 density:1 bootstrap:0.57741673 cc_score:0.0 bp_score:0.377128 mf_score:0.0 relationship: child_of NeXO:6748 ! CC: | BP: | MF: [Term] id: NeXO:6106 name: CC: | BP: positive regulation of protein oligomerization | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of protein oligomerization. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80081062 cc_score:0.0 bp_score:0.231271 mf_score:0.0 relationship: child_of NeXO:6523 ! CC: | BP: late endosome to vacuole transport via multivesicular body sorting pathway | MF: [Term] id: NeXO:6105 name: CC: | BP: formaldehyde catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.45783888532058 density:0.5 bootstrap:0.79105609 cc_score:0.0 bp_score:0.160054 mf_score:0.0 relationship: child_of NeXO:6734 ! CC: | BP: | MF: [Term] id: NeXO:6104 name: CC: | BP: ethanol oxidation | MF:S-(hydroxymethyl)glutathione dehydrogenase activity def: "CC_def: | BP_def: An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. | MF_def:Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.6037374701857 density:0.666666666666667 bootstrap:0.617827629 cc_score:0.0 bp_score:0.31467 mf_score:0.31311 relationship: child_of NeXO:6105 ! CC: | BP: formaldehyde catabolic process | MF: [Term] id: NeXO:6103 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03027002352296 density:0.333333333333333 bootstrap:0.83461593 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7520 ! CC: | BP: | MF: [Term] id: NeXO:6102 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.74460535073469 density:0.333333333333333 bootstrap:0.61627346 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6582 ! CC: | BP: | MF: [Term] id: NeXO:6101 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06949687867758 density:0.666666666666667 bootstrap:0.858632518 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6130 ! CC: nuclear inner membrane | BP: | MF: [Term] id: NeXO:6100 name: CC: | BP: deoxycytidine catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.45083070253568 density:0.5 bootstrap:0.78785279 cc_score:0.0 bp_score:0.201155 mf_score:0.0 relationship: child_of NeXO:6853 ! CC: | BP: | MF: [Term] id: NeXO:9790 name: CC: septin ring | BP: septin ring organization | MF: def: "CC_def: A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. | BP_def: Control of the formation, spatial distribution, and breakdown of the septin ring. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.77798858227591 density:0.197628458498024 bootstrap:0.256269523 cc_score:0.17642 bp_score:0.150762 mf_score:0.046525 relationship: child_of NeXO:9931 ! CC: | BP: regulation of protein kinase activity | MF: [Term] id: NeXO:9797 name: CC: | BP: cofactor catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.1026533201685 density:0.087037037037037 bootstrap:0.199757117 cc_score:0.0 bp_score:0.105715 mf_score:0.02303 relationship: child_of NeXO:9907 ! CC: | BP: | MF: [Term] id: NeXO:8857 name: CC: autophagic vacuole | BP: C-terminal protein amino acid modification | MF:Atg8 ligase activity def: "CC_def: A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast. | BP_def: The alteration of the C-terminal amino acid residue in a protein. | MF_def:Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.456057613 cc_score:0.220078 bp_score:0.171685 mf_score:0.339029 relationship: child_of NeXO:9580 ! CC: pre-autophagosomal structure | BP: piecemeal microautophagy of nucleus | MF: [Term] id: NeXO:9119 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.10168939346475 density:0.733333333333333 bootstrap:0.439821218 cc_score:0.0 bp_score:0.0398159 mf_score:0.0 relationship: child_of NeXO:9261 ! CC: heterochromatin | BP: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:8888 ! CC: Pwp2p-containing subcomplex of 90S preribosome | BP: | MF: [Term] id: NeXO:9118 name: CC: | BP: microtubule bundle formation | MF: def: "CC_def: | BP_def: A process that results in a parallel arrangement of microtubules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.39761938873795 density:0.166666666666667 bootstrap:0.459692145 cc_score:0.0 bp_score:0.207283 mf_score:0.0 relationship: child_of NeXO:9703 ! CC: | BP: | MF: [Term] id: NeXO:9449 name: CC: exosome (RNase complex) | BP: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: Complex of 3'-5' exoribonucleases. | BP_def: Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:18.7254222995997 density:0.819047619047619 bootstrap:0.74315701 cc_score:0.59554 bp_score:0.498526 mf_score:0.0617584 relationship: child_of NeXO:9915 ! CC: DNA-directed RNA polymerase complex | BP: polyadenylation-dependent mRNA catabolic process | MF:nucleotidyltransferase activity [Term] id: NeXO:9111 name: CC: | BP: positive regulation of transcription from RNA polymerase III promoter | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.70303984443341 density:0.666666666666667 bootstrap:0.639694131 cc_score:0.0 bp_score:0.19346 mf_score:0.0 relationship: child_of NeXO:9654 ! CC: | BP: | MF: [Term] id: NeXO:9110 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08581973927357 density:0.0526315789473684 bootstrap:0.115260162 cc_score:0.0 bp_score:0.036861 mf_score:0.0220446 relationship: child_of NeXO:9542 ! CC: | BP: | MF: [Term] id: NeXO:9113 name: CC: Ada2/Gcn5/Ada3 transcription activator complex | BP: positive regulation of histone acetylation | MF:phosphatidylserine binding def: "CC_def: A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. | BP_def: Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. | MF_def:Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.90988530118376 density:1 bootstrap:0.60441665 cc_score:0.253544 bp_score:0.148105 mf_score:0.438225 relationship: child_of NeXO:9672 ! CC: | BP: | MF: relationship: linked_to NeXO:8805 ! CC: DUBm complex | BP: histone deubiquitination | MF:histone H3-K18 acetylation relationship: linked_to NeXO:9204 ! CC: | BP: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | MF:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity relationship: linked_to NeXO:8661 ! CC: | BP: | MF: [Term] id: NeXO:9444 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.70025727563764 density:0.0254706533776301 bootstrap:0.201492299 cc_score:0.0 bp_score:0.0435733 mf_score:0.0182601 relationship: child_of NeXO:9823 ! CC: | BP: | MF: [Term] id: NeXO:9115 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54124322 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9371 ! CC: | BP: | MF: relationship: linked_to NeXO:8457 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:9442 name: CC: guanyl-nucleotide exchange factor complex | BP: | MF: def: "CC_def: A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.90439556016874 density:0.258333333333333 bootstrap:0.198392402 cc_score:0.210348 bp_score:0.0 mf_score:0.0579387 relationship: child_of NeXO:9740 ! CC: | BP: translational initiation | MF:translation initiation factor activity [Term] id: NeXO:9441 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04089809126577 density:0.0513833992094862 bootstrap:0.139202219 cc_score:0.0 bp_score:0.0372057 mf_score:0.0 relationship: child_of NeXO:9824 ! CC: | BP: | MF: [Term] id: NeXO:9440 name: CC: | BP: regulation of pseudohyphal growth | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of pseudohyphal growth. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.63263323538107 density:0.145454545454545 bootstrap:0.252386141 cc_score:0.0 bp_score:0.19865 mf_score:0.0 relationship: child_of NeXO:9739 ! CC: | BP: regulation of growth of unicellular organism as a thread of attached cells | MF: [Term] id: NeXO:9162 name: CC: DNA polymerase complex | BP: cellular response to cold | MF:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water def: "CC_def: A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [NeXO-GO:term] namespace: NeXO comment: robustness:2.0288204250364 density:0.4 bootstrap:0.218888141 cc_score:0.11533 bp_score:0.220254 mf_score:0.114869 relationship: child_of NeXO:9698 ! CC: | BP: leading strand elongation | MF: [Term] id: NeXO:5753 name: CC: | BP: protein autoubiquitination | MF: def: "CC_def: | BP_def: The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8130307 cc_score:0.0 bp_score:0.438574 mf_score:0.0 relationship: child_of NeXO:6189 ! CC: | BP: | MF: [Term] id: NeXO:5752 name: CC: | BP: glyoxylate cycle | MF:isocitrate dehydrogenase (NADP+) activity def: "CC_def: | BP_def: A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. | MF_def:Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.1813838343567 density:1 bootstrap:0.78847155 cc_score:0.0 bp_score:0.200814 mf_score:0.603252 relationship: child_of NeXO:6191 ! CC: | BP: glyoxylate metabolic process | MF: [Term] id: NeXO:6108 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99810935726353 density:0.333333333333333 bootstrap:0.808383745 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7676 ! CC: | BP: | MF: [Term] id: NeXO:5751 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.4148227912706 density:1 bootstrap:0.96625639 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7835 ! CC: | BP: | MF: [Term] id: NeXO:6981 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.65305929460251 density:0.333333333333333 bootstrap:0.553293959 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7063 ! CC: | BP: | MF: [Term] id: NeXO:6039 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76023315 cc_score:0.0 bp_score:0.0123145 mf_score:0.0 relationship: child_of NeXO:7457 ! CC: | BP: | MF: [Term] id: NeXO:9826 name: CC: | BP: regulation of telomerase activity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.04206010268427 density:0.333333333333333 bootstrap:0.219869304 cc_score:0.0 bp_score:0.234592 mf_score:0.0 relationship: child_of NeXO:9916 ! CC: polysomal ribosome | BP: | MF: relationship: linked_to NeXO:6601 ! CC: | BP: | MF:malate synthase activity relationship: linked_to NeXO:7177 ! CC: | BP: | MF: relationship: linked_to NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:5148 ! CC: | BP: | MF:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Term] id: NeXO:6452 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.750288023 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7682 ! CC: | BP: beta-glucan biosynthetic process | MF: [Term] id: NeXO:6033 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63388084 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6431 ! CC: | BP: lipid translocation | MF:phospholipid transporter activity [Term] id: NeXO:9821 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.21826915137079 density:0.0105801445953095 bootstrap:0.107701634 cc_score:0.0304647 bp_score:0.0220545 mf_score:0.0129246 relationship: child_of NeXO:9929 ! CC: | BP: | MF: [Term] id: NeXO:5116 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88147823 cc_score:0.0 bp_score:0.0432863 mf_score:0.0964378 relationship: child_of NeXO:5373 ! CC: | BP: | MF: [Term] id: NeXO:6037 name: CC: protein farnesyltransferase complex | BP: protein farnesylation | MF:protein farnesyltransferase activity def: "CC_def: A protein complex that possesses protein farnesyltransferase activity. | BP_def: The covalent attachment of a farnesyl group to a protein. | MF_def:Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.60783313876615 density:0.5 bootstrap:0.8611735 cc_score:0.4064 bp_score:0.421643 mf_score:0.421758 relationship: child_of NeXO:6823 ! CC: | BP: protein prenylation | MF:protein prenyltransferase activity [Term] id: NeXO:6036 name: CC: | BP: | MF:sodium:hydrogen antiporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.361438185 cc_score:0.0 bp_score:0.0 mf_score:0.164198 relationship: child_of NeXO:6370 ! CC: | BP: | MF: [Term] id: NeXO:6035 name: CC: | BP: mitochondrial magnesium ion transport | MF: def: "CC_def: | BP_def: The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69513149 cc_score:0.0 bp_score:0.300564 mf_score:0.0 relationship: child_of NeXO:6372 ! CC: | BP: | MF:magnesium ion transmembrane transporter activity [Term] id: NeXO:9820 name: CC: | BP: vesicle targeting, to, from or within Golgi | MF: def: "CC_def: | BP_def: The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.12686145079841 density:0.241830065359477 bootstrap:0.185705288 cc_score:0.0977269 bp_score:0.163779 mf_score:0.045866 relationship: child_of NeXO:9902 ! CC: | BP: membrane budding | MF: [Term] id: NeXO:8233 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.995511560579 density:0.252747252747253 bootstrap:0.277682248 cc_score:0.0568369 bp_score:0.0997397 mf_score:0.0244537 relationship: child_of NeXO:8816 ! CC: | BP: | MF: [Term] id: NeXO:5171 name: CC: | BP: | MF:glycolipid mannosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.901074203 cc_score:0.0 bp_score:0.0 mf_score:0.561419 relationship: child_of NeXO:6395 ! CC: | BP: oligosaccharide-lipid intermediate biosynthetic process | MF:chitobiosyldiphosphodolichol beta-mannosyltransferase activity [Term] id: NeXO:5177 name: CC: crista junction | BP: carnitine transport | MF:carnitine transporter activity def: "CC_def: Tubular structures of relatively uniform size that connect mitochondrial cristae to the inner mitchondrial membrane. | BP_def: The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. | MF_def:Enables the directed movement of carnitine into, out of or within a cell, or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90328518 cc_score:0.125143 bp_score:0.446724 mf_score:0.440034 relationship: child_of NeXO:7425 ! CC: | BP: telomeric 3' overhang formation | MF: [Term] id: NeXO:9823 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.42068023904056 density:0.0592492085029398 bootstrap:0.234889822 cc_score:0.0 bp_score:0.0208781 mf_score:0.0 relationship: child_of NeXO:10016 ! CC: | BP: | MF: [Term] id: NeXO:5175 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33431422608965 density:1 bootstrap:0.90290172 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5176 ! CC: | BP: | MF: [Term] id: NeXO:5179 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7016225 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5186 ! CC: | BP: | MF:ketoreductase activity [Term] id: NeXO:6913 name: CC: | BP: glycosphingolipid biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.91983096192151 density:0.666666666666667 bootstrap:0.77694157 cc_score:0.0 bp_score:0.425647 mf_score:0.0 relationship: child_of NeXO:7189 ! CC: | BP: | MF:protein C-terminal leucine carboxyl O-methyltransferase activity [Term] id: NeXO:9209 name: CC: Set1C/COMPASS complex | BP: histone H3-K4 methylation | MF:histone methyltransferase activity (H3-K4 specific) def: "CC_def: A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. | BP_def: The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:11.5389955561659 density:0.654545454545455 bootstrap:0.72340489 cc_score:0.453556 bp_score:0.267067 mf_score:0.458387 relationship: child_of NeXO:9586 ! CC: methyltransferase complex | BP: histone methylation | MF:histone methylation [Term] id: NeXO:6831 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.45955770102539 density:0.5 bootstrap:0.80660681 cc_score:0.0 bp_score:0.0307657 mf_score:0.0 relationship: child_of NeXO:6844 ! CC: | BP: | MF: [Term] id: NeXO:8530 name: CC: | BP: plus-end specific microtubule depolymerization | MF:tubulin-dependent ATPase activity def: "CC_def: | BP_def: The removal of tubulin heterodimers from the plus end of a microtubule. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.68733084183907 density:1 bootstrap:0.75096966 cc_score:0.0 bp_score:0.297787 mf_score:0.292114 relationship: child_of NeXO:9703 ! CC: | BP: | MF: relationship: linked_to NeXO:9118 ! CC: | BP: microtubule bundle formation | MF: relationship: linked_to NeXO:9342 ! CC: | BP: negative regulation of transcription factor import into nucleus | MF: relationship: linked_to NeXO:9356 ! CC: prefoldin complex | BP: tubulin complex assembly | MF: [Term] id: NeXO:7388 name: CC: | BP: negative regulation of phospholipid translocation | MF: def: "CC_def: | BP_def: Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.73944083092828 density:1 bootstrap:0.501350171 cc_score:0.0 bp_score:0.440406 mf_score:0.0 relationship: child_of NeXO:7633 ! CC: | BP: regulation of phospholipid translocation | MF: [Term] id: NeXO:7389 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.9402613467654 density:1 bootstrap:0.623795605 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8278 ! CC: | BP: | MF: relationship: linked_to NeXO:9001 ! CC: | BP: activation of Ras GTPase activity | MF: [Term] id: NeXO:9987 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.92537759580997 density:0.00338904044687956 bootstrap:0.163505378 cc_score:0.0794268 bp_score:0.0851759 mf_score:0.0636559 relationship: child_of NeXO:10001 ! CC: membrane | BP: primary metabolic process | MF:metabolic process [Term] id: NeXO:7383 name: CC: DNA replication factor A complex | BP: | MF: def: "CC_def: A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5307817902486 density:1 bootstrap:0.68855706 cc_score:0.439911 bp_score:0.0487041 mf_score:0.0 relationship: child_of NeXO:7903 ! CC: | BP: | MF: [Term] id: NeXO:7380 name: CC: | BP: negative regulation of transcription involved in G1 phase of mitotic cell cycle | MF: def: "CC_def: | BP_def: Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.570490264 cc_score:0.0 bp_score:0.354551 mf_score:0.0440328 relationship: child_of NeXO:8262 ! CC: MBF transcription complex | BP: GO:0090419 | MF: [Term] id: NeXO:7381 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.77752224469932 density:0.25 bootstrap:0.50413351 cc_score:0.0 bp_score:0.0718326 mf_score:0.0 relationship: child_of NeXO:8209 ! CC: | BP: | MF: [Term] id: NeXO:7386 name: CC: | BP: protein retention in ER lumen | MF: def: "CC_def: | BP_def: The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.80834494479524 density:1 bootstrap:0.54185664 cc_score:0.0 bp_score:0.128153 mf_score:0.0 relationship: child_of NeXO:8122 ! CC: | BP: | MF: [Term] id: NeXO:9984 name: CC: catalytic step 1 spliceosome | BP: nuclear mRNA splicing, via spliceosome | MF: def: "CC_def: A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. | BP_def: The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.8859126182703 density:0.418357487922705 bootstrap:0.388857205 cc_score:0.353536 bp_score:0.341742 mf_score:0.0 relationship: child_of NeXO:9985 ! CC: U2-type spliceosomal complex | BP: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | MF: [Term] id: NeXO:7384 name: CC: | BP: | MF:phosphoribosylformylglycinamidine cyclo-ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.74016053570474 density:1 bootstrap:0.77264263 cc_score:0.0 bp_score:0.0850489 mf_score:0.297149 relationship: child_of NeXO:8435 ! CC: | BP: IMP biosynthetic process | MF:hydroxymethyl-, formyl- and related transferase activity relationship: linked_to NeXO:7589 ! CC: | BP: | MF:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Term] id: NeXO:6369 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.346030544 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6859 ! CC: | BP: | MF:ubiquitin-ubiquitin ligase activity [Term] id: NeXO:8533 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.01514964623037 density:0.0394088669950739 bootstrap:0.28135867 cc_score:0.0 bp_score:0.0785644 mf_score:0.0 relationship: child_of NeXO:9453 ! CC: | BP: | MF: [Term] id: NeXO:9982 name: CC: chromatin remodeling complex | BP: nucleosome organization | MF: def: "CC_def: Any complex that mediates dynamic changes in eukaryotic chromatin. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.3144613502258 density:0.0645792563600783 bootstrap:0.319848654 cc_score:0.331429 bp_score:0.223001 mf_score:0.0607127 relationship: child_of NeXO:9989 ! CC: nucleoplasm part | BP: chromatin modification | MF:transcription, DNA-dependent [Term] id: NeXO:8535 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.545283574 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8944 ! CC: Nup82 complex | BP: ncRNA export from nucleus | MF: relationship: linked_to NeXO:8783 ! CC: | BP: snRNP protein import into nucleus | MF: [Term] id: NeXO:6327 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68807253 cc_score:0.0 bp_score:0.0881951 mf_score:0.0 relationship: child_of NeXO:6932 ! CC: | BP: | MF: [Term] id: NeXO:6326 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7675238 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6794 ! CC: | BP: | MF: relationship: linked_to NeXO:7218 ! CC: | BP: positive regulation of mitochondrial DNA replication | MF: relationship: linked_to NeXO:8172 ! CC: | BP: | MF: [Term] id: NeXO:6325 name: CC: mitochondrial ribonuclease P complex | BP: | MF: def: "CC_def: A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76337752 cc_score:0.169145 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7011 ! CC: | BP: | MF: [Term] id: NeXO:6324 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.70863891 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7090 ! CC: PAN complex | BP: | MF: [Term] id: NeXO:8024 name: CC: | BP: | MF:intramolecular oxidoreductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [NeXO-GO:term] namespace: NeXO comment: robustness:2.66436464723533 density:0.068421052631579 bootstrap:0.211201351 cc_score:0.0 bp_score:0.0650923 mf_score:0.166207 relationship: child_of NeXO:9028 ! CC: | BP: | MF: [Term] id: NeXO:6321 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.93851226586636 density:0.333333333333333 bootstrap:0.760880005 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7095 ! CC: | BP: | MF: [Term] id: NeXO:6320 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75107504533281 density:1 bootstrap:0.50807914 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6321 ! CC: | BP: | MF: [Term] id: NeXO:9681 name: CC: central plaque of spindle pole body | BP: spindle pole body duplication | MF: def: "CC_def: One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope. | BP_def: Construction of a new spindle pole body. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.34380403315455 density:0.678571428571429 bootstrap:0.288611864 cc_score:0.25528 bp_score:0.209045 mf_score:0.0 relationship: child_of NeXO:9835 ! CC: spindle pole body | BP: microtubule nucleation | MF:structural constituent of cytoskeleton [Term] id: NeXO:9680 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.8456503416184 density:0.153846153846154 bootstrap:0.196708967 cc_score:0.0 bp_score:0.0946567 mf_score:0.0 relationship: child_of NeXO:9846 ! CC: | BP: | MF: [Term] id: NeXO:9683 name: CC: | BP: MAP kinase activity | MF:MAP kinase activity def: "CC_def: | BP_def: Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. | MF_def:Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [NeXO-GO:term] namespace: NeXO comment: robustness:3.35985764120743 density:0.6 bootstrap:0.365663384 cc_score:0.0 bp_score:0.140722 mf_score:0.345059 relationship: child_of NeXO:9791 ! CC: | BP: signal transduction involved in filamentous growth | MF:receptor signaling protein serine/threonine kinase activity relationship: linked_to NeXO:8444 ! CC: | BP: two-component signal transduction system (phosphorelay) | MF:two-component signal transduction system (phosphorelay) [Term] id: NeXO:8025 name: CC: | BP: resolution of recombination intermediates | MF: def: "CC_def: | BP_def: The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.81629753283445 density:0.311111111111111 bootstrap:0.395025961 cc_score:0.0237248 bp_score:0.155356 mf_score:0.0 relationship: child_of NeXO:8850 ! CC: | BP: | MF: [Term] id: NeXO:9685 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.7749802743252 density:1 bootstrap:0.600864727 cc_score:0.0 bp_score:0.0341119 mf_score:0.0 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: relationship: linked_to NeXO:9769 ! CC: | BP: ribosomal large subunit assembly | MF: [Term] id: NeXO:9687 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.14562695295289 density:0.333333333333333 bootstrap:0.333533911 cc_score:0.0 bp_score:0.0915166 mf_score:0.0 relationship: child_of NeXO:9873 ! CC: | BP: spindle pole body separation | MF:cyclin-dependent protein kinase activity [Term] id: NeXO:9686 name: CC: | BP: ATP-dependent chromatin remodeling | MF: def: "CC_def: | BP_def: Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:24.5228318940703 density:0.605072463768116 bootstrap:0.82012928 cc_score:0.0 bp_score:0.366564 mf_score:0.0 relationship: child_of NeXO:9847 ! CC: | BP: chromatin remodeling | MF: [Term] id: NeXO:9060 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.70784560665148 density:1 bootstrap:0.483302521 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9379 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:8304 ! CC: | BP: | MF: [Term] id: NeXO:9064 name: CC: | BP: positive regulation of formin-nucleated actin cable assembly | MF: def: "CC_def: | BP_def: Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63057777 cc_score:0.0 bp_score:0.179936 mf_score:0.0 relationship: child_of NeXO:9350 ! CC: | BP: | MF: relationship: linked_to NeXO:7957 ! CC: | BP: | MF:tRNA (cytosine) methyltransferase activity relationship: linked_to NeXO:9112 ! CC: tight junction | BP: | MF: [Term] id: NeXO:8521 name: CC: nuclear SCF ubiquitin ligase complex | BP: | MF: def: "CC_def: A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97528396001825 density:1 bootstrap:0.646518447 cc_score:0.294806 bp_score:0.0680201 mf_score:0.0 relationship: child_of NeXO:9340 ! CC: | BP: | MF: relationship: linked_to NeXO:7720 ! CC: | BP: | MF: [Term] id: NeXO:5590 name: CC: phosphatidylinositol 3-kinase complex I | BP: phosphatidylinositol-mediated signaling | MF:1-phosphatidylinositol-3-kinase activity def: "CC_def: A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p. | BP_def: A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. | MF_def:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.38030354418445 density:1 bootstrap:0.93882908 cc_score:0.45647 bp_score:0.230632 mf_score:0.227756 relationship: child_of NeXO:7840 ! CC: phosphatidylinositol 3-kinase complex II | BP: inositol lipid-mediated signaling | MF: [Term] id: NeXO:5618 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91258822 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6586 ! CC: | BP: | MF: [Term] id: NeXO:6457 name: CC: | BP: | MF:GO:0052723 def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.97493460758052 density:0.0666666666666667 bootstrap:0.284266694 cc_score:0.0 bp_score:0.0 mf_score:0.113438 relationship: child_of NeXO:6761 ! CC: | BP: | MF: [Term] id: NeXO:9667 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.7057392862303 density:0.575757575757576 bootstrap:0.405846921 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9809 ! CC: | BP: | MF: [Term] id: NeXO:9666 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.9499351572099 density:0.423809523809524 bootstrap:0.6403089 cc_score:0.0879604 bp_score:0.0359732 mf_score:0.0 relationship: child_of NeXO:9759 ! CC: | BP: | MF: [Term] id: NeXO:9664 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.67329993287881 density:0.0268292682926829 bootstrap:0.199885532 cc_score:0.0 bp_score:0.0588679 mf_score:0.0 relationship: child_of NeXO:9860 ! CC: | BP: | MF: [Term] id: NeXO:9663 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.8429240868582 density:0.582417582417582 bootstrap:0.538144161 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10003 ! CC: cytosolic small ribosomal subunit | BP: | MF: [Term] id: NeXO:9662 name: CC: | BP: vesicle docking | MF: def: "CC_def: | BP_def: The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.03041129121472 density:0.316666666666667 bootstrap:0.314468423 cc_score:0.0797429 bp_score:0.173033 mf_score:0.0 relationship: child_of NeXO:9878 ! CC: | BP: membrane docking | MF: [Term] id: NeXO:9661 name: CC: nuclear envelope lumen | BP: positive regulation of gluconeogenesis | MF: def: "CC_def: The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. | BP_def: Any process that activates or increases the frequency, rate or extent of gluconeogenesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.92128240304274 density:0.607142857142857 bootstrap:0.408918254 cc_score:0.248318 bp_score:0.252895 mf_score:0.0 relationship: child_of NeXO:9910 ! CC: | BP: | MF: [Term] id: NeXO:9660 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.17940497906757 density:0.222222222222222 bootstrap:0.262258495 cc_score:0.0 bp_score:0.0945999 mf_score:0.0 relationship: child_of NeXO:9858 ! CC: | BP: | MF: [Term] id: NeXO:7445 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.65115971259974 density:0.0769230769230769 bootstrap:0.413591621 cc_score:0.0 bp_score:0.0515649 mf_score:0.0976166 relationship: child_of NeXO:8681 ! CC: | BP: | MF: [Term] id: NeXO:7953 name: CC: | BP: 'de novo' IMP biosynthetic process | MF:phosphoribosylformylglycinamidine synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. | MF_def:Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:5.0984472223032 density:0.8 bootstrap:0.58441914 cc_score:0.0 bp_score:0.463316 mf_score:0.214763 relationship: child_of NeXO:8435 ! CC: | BP: IMP biosynthetic process | MF:hydroxymethyl-, formyl- and related transferase activity [Term] id: NeXO:7444 name: CC: | BP: organic acid phosphorylation | MF:phosphomevalonate kinase activity def: "CC_def: | BP_def: The process of introducing one or more phosphate groups into an organic acid. | MF_def:Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.810590287 cc_score:0.0 bp_score:0.437995 mf_score:0.439152 relationship: child_of NeXO:8067 ! CC: Rad17 RFC-like complex | BP: isopentenyl diphosphate biosynthetic process, mevalonate pathway | MF:DNA clamp loader activity [Term] id: NeXO:7254 name: CC: | BP: prolyl-tRNA aminoacylation | MF:proline-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.290606325 cc_score:0.0 bp_score:0.230616 mf_score:0.230478 relationship: child_of NeXO:8192 ! CC: | BP: | MF: [Term] id: NeXO:7255 name: CC: | BP: | MF:cytochrome-b5 reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80230123 cc_score:0.0 bp_score:0.0 mf_score:0.299289 relationship: child_of NeXO:8133 ! CC: | BP: | MF: relationship: linked_to NeXO:8546 ! CC: | BP: negative regulation of glycogen catabolic process | MF: [Term] id: NeXO:7257 name: CC: | BP: peptidyl-arginine methylation | MF:protein-arginine N5-methyltransferase activity def: "CC_def: | BP_def: The addition of a methyl group to an arginine residue in a protein. | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.685104566 cc_score:0.0 bp_score:0.292511 mf_score:0.446512 relationship: child_of NeXO:8283 ! CC: | BP: | MF:protein-arginine N-methyltransferase activity relationship: linked_to NeXO:9091 ! CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: [Term] id: NeXO:7250 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.32520744904874 density:0.0888888888888889 bootstrap:0.43930919 cc_score:0.0 bp_score:0.0731005 mf_score:0.0 relationship: child_of NeXO:8018 ! CC: | BP: | MF: [Term] id: NeXO:7251 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.49011001978251 density:0.333333333333333 bootstrap:0.44958906 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8698 ! CC: | BP: | MF: relationship: linked_to NeXO:6169 ! CC: | BP: | MF: [Term] id: NeXO:7252 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.6464976149467 density:0.981818181818182 bootstrap:0.666348093 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8698 ! CC: | BP: | MF: [Term] id: NeXO:7253 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.60618986313019 density:0.0833333333333333 bootstrap:0.73106686 cc_score:0.0 bp_score:0.0897234 mf_score:0.0931949 relationship: child_of NeXO:7849 ! CC: | BP: | MF: [Term] id: NeXO:6489 name: CC: tricarboxylic acid cycle enzyme complex | BP: fumarate metabolic process | MF:fumarate hydratase activity def: "CC_def: Any of the heteromeric enzymes that act in the TCA cycle. | BP_def: The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. | MF_def:Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [NeXO-GO:term] namespace: NeXO comment: robustness:2.05020480170744 density:1 bootstrap:0.696492332 cc_score:0.229724 bp_score:0.294199 mf_score:0.439193 relationship: child_of NeXO:6962 ! CC: | BP: | MF: [Term] id: NeXO:7258 name: CC: EKC/KEOPS complex | BP: threonylcarbamoyladenosine metabolic process | MF:chromatin DNA binding def: "CC_def: A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. | BP_def: The chemical reactions and pathways involving threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. | MF_def:Interacting selectively and non-covalently with DNA that is assembled into chromatin." [NeXO-GO:term] namespace: NeXO comment: robustness:4.44232431717524 density:0.5 bootstrap:0.8003848 cc_score:0.526025 bp_score:0.153258 mf_score:0.270262 relationship: child_of NeXO:7676 ! CC: | BP: | MF: [Term] id: NeXO:7259 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.528674307 cc_score:0.0 bp_score:0.0416667 mf_score:0.0 relationship: child_of NeXO:8127 ! CC: | BP: | MF: [Term] id: NeXO:8978 name: CC: | BP: cysteine biosynthetic process | MF:cysteine biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. | MF_def:The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [NeXO-GO:term] namespace: NeXO comment: robustness:7.07854048073189 density:0.320512820512821 bootstrap:0.479845994 cc_score:0.0 bp_score:0.30024 mf_score:0.294586 relationship: child_of NeXO:9337 ! CC: | BP: cysteine metabolic process | MF:methionine biosynthetic process [Term] id: NeXO:6565 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.99211685330457 density:0.5 bootstrap:0.592317919 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6941 ! CC: clathrin coat of coated pit | BP: | MF: [Term] id: NeXO:5332 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.864685565 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6470 ! CC: | BP: | MF: [Term] id: NeXO:5613 name: CC: | BP: | MF:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.74523545 cc_score:0.0 bp_score:0.0 mf_score:0.442252 relationship: child_of NeXO:5773 ! CC: | BP: | MF:lipid phosphatase activity relationship: linked_to NeXO:7437 ! CC: | BP: | MF: [Term] id: NeXO:8970 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.7688190001454 density:0.733333333333333 bootstrap:0.56236978 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9531 ! CC: | BP: | MF: [Term] id: NeXO:8971 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.98403873188456 density:0.0270270270270270 bootstrap:0.284876224 cc_score:0.0 bp_score:0.0186519 mf_score:0.0 relationship: child_of NeXO:9704 ! CC: | BP: | MF: [Term] id: NeXO:8972 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30432915920399 density:0.109090909090909 bootstrap:0.277590853 cc_score:0.0 bp_score:0.0683877 mf_score:0.0643253 relationship: child_of NeXO:9307 ! CC: | BP: | MF: [Term] id: NeXO:8973 name: CC: | BP: | MF:drug transmembrane transport def: "CC_def: | BP_def: | MF_def:The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:3.02367499447123 density:0.0661764705882353 bootstrap:0.389909121 cc_score:0.0 bp_score:0.0578315 mf_score:0.135662 relationship: child_of NeXO:9731 ! CC: nuclear ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:8554 name: CC: MCM complex | BP: | MF: def: "CC_def: A hexameric protein complex required for the initiation and regulation of DNA replication. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.79361161018019 density:0.8 bootstrap:0.754653048 cc_score:0.448379 bp_score:0.0933029 mf_score:0.0 relationship: child_of NeXO:9411 ! CC: CMG complex | BP: S phase of mitotic cell cycle | MF:DNA replication origin binding [Term] id: NeXO:5610 name: CC: | BP: regulation of glycogen biosynthetic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80181738 cc_score:0.0 bp_score:0.221386 mf_score:0.0 relationship: child_of NeXO:6067 ! CC: | BP: regulation of glycogen metabolic process | MF:glycogenin glucosyltransferase activity [Term] id: NeXO:8976 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.67130808430196 density:0.333333333333333 bootstrap:0.298159 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9487 ! CC: | BP: | MF: [Term] id: NeXO:8977 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89712764262208 density:1 bootstrap:0.59636885 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9463 ! CC: | BP: | MF: relationship: linked_to NeXO:9481 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9225 ! CC: | BP: | MF: [Term] id: NeXO:6855 name: CC: | BP: | MF:flavin-linked sulfhydryl oxidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the formation of disulfide bridges." [NeXO-GO:term] namespace: NeXO comment: robustness:4.04204865994553 density:0.666666666666667 bootstrap:0.76218197 cc_score:0.0 bp_score:0.0 mf_score:0.255899 relationship: child_of NeXO:6868 ! CC: | BP: | MF: [Term] id: NeXO:6854 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.84135075127807 density:0.2 bootstrap:0.672415119 cc_score:0.0 bp_score:0.0833318 mf_score:0.0 relationship: child_of NeXO:7623 ! CC: | BP: | MF: [Term] id: NeXO:6857 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82516285 cc_score:0.0 bp_score:0.0 mf_score:0.0454347 relationship: child_of NeXO:8537 ! CC: | BP: | MF: relationship: linked_to NeXO:8530 ! CC: | BP: plus-end specific microtubule depolymerization | MF:tubulin-dependent ATPase activity [Term] id: NeXO:6566 name: CC: | BP: peptidyl-lysine deacetylation | MF:NAD-dependent histone deacetylase activity (H4-K16 specific) def: "CC_def: | BP_def: The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. | MF_def:Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75128142 cc_score:0.0 bp_score:0.439261 mf_score:0.13086 relationship: child_of NeXO:7170 ! CC: | BP: GO:0061393 | MF:mitogen-activated protein kinase binding [Term] id: NeXO:6851 name: CC: | BP: | MF:tRNA dihydrouridine synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:2.49534005815229 density:0.5 bootstrap:0.411962085 cc_score:0.0 bp_score:0.0 mf_score:0.133661 relationship: child_of NeXO:6937 ! CC: | BP: | MF: [Term] id: NeXO:6850 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.313324456 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6851 ! CC: | BP: | MF:tRNA dihydrouridine synthase activity [Term] id: NeXO:6853 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.86238698441633 density:0.111111111111111 bootstrap:0.262409868 cc_score:0.0 bp_score:0.0816956 mf_score:0.0665209 relationship: child_of NeXO:7907 ! CC: | BP: | MF: [Term] id: NeXO:6852 name: CC: | BP: positive regulation of ligase activity | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.55456495 cc_score:0.0 bp_score:0.15116 mf_score:0.0 relationship: child_of NeXO:7828 ! CC: | BP: | MF:tRNA binding [Term] id: NeXO:5616 name: CC: | BP: meiotic DNA recombinase assembly | MF: def: "CC_def: | BP_def: During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68767551 cc_score:0.0 bp_score:0.148349 mf_score:0.0 relationship: child_of NeXO:5718 ! CC: | BP: | MF: [Term] id: NeXO:6459 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.639300632 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6974 ! CC: | BP: water transport | MF:water channel activity [Term] id: NeXO:6859 name: CC: | BP: | MF:ubiquitin-ubiquitin ligase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine. This reaction is the ligation of ubiquitin groups, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.31216863749499 density:0.333333333333333 bootstrap:0.348624875 cc_score:0.0 bp_score:0.0847142 mf_score:0.339118 relationship: child_of NeXO:7162 ! CC: | BP: | MF: [Term] id: NeXO:6858 name: CC: | BP: methionine biosynthetic process | MF:uroporphyrin-III C-methyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [NeXO-GO:term] namespace: NeXO comment: robustness:3.55582846548237 density:0.666666666666667 bootstrap:0.589844047 cc_score:0.0 bp_score:0.102261 mf_score:0.25436 relationship: child_of NeXO:7223 ! CC: | BP: sulfate assimilation | MF:sulfate adenylyltransferase (ATP) activity [Term] id: NeXO:7139 name: CC: | BP: | MF:ribonuclease III activity def: "CC_def: | BP_def: | MF_def:Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.60250695 cc_score:0.0 bp_score:0.0 mf_score:0.182396 relationship: child_of NeXO:7746 ! CC: | BP: | MF: [Term] id: NeXO:7138 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.432487429 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8138 ! CC: | BP: | MF: [Term] id: NeXO:8138 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.370945993 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9123 ! CC: | BP: | MF: [Term] id: NeXO:7131 name: CC: | BP: | MF:cholesterol binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93400953 cc_score:0.0 bp_score:0.0959623 mf_score:0.443243 relationship: child_of NeXO:7132 ! CC: | BP: | MF: [Term] id: NeXO:7130 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95373615026929 density:0.333333333333333 bootstrap:0.772877901 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8080 ! CC: | BP: | MF: [Term] id: NeXO:7133 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02514593039757 density:0.0952380952380952 bootstrap:0.607296493 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8394 ! CC: | BP: | MF: [Term] id: NeXO:7132 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.0761271209719 density:0.333333333333333 bootstrap:0.872744154 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7133 ! CC: | BP: | MF: [Term] id: NeXO:7135 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56278214 cc_score:0.0 bp_score:0.055924 mf_score:0.0409891 relationship: child_of NeXO:8046 ! CC: | BP: | MF: [Term] id: NeXO:7014 name: CC: | BP: | MF:methylenetetrahydrofolate reductase (NADPH) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.416281906 cc_score:0.0 bp_score:0.0262803 mf_score:0.295255 relationship: child_of NeXO:7873 ! CC: | BP: | MF: [Term] id: NeXO:7137 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05569123942112 density:0.333333333333333 bootstrap:0.8556474 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7979 ! CC: | BP: | MF: relationship: linked_to NeXO:7980 ! CC: | BP: nuclear mRNA 3'-splice site recognition | MF: [Term] id: NeXO:8526 name: CC: | BP: ribose phosphate biosynthetic process | MF:diphosphotransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar. | MF_def:Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.34721293519636 density:0.25 bootstrap:0.395820413 cc_score:0.0 bp_score:0.334783 mf_score:0.295255 relationship: child_of NeXO:8995 ! CC: | BP: ribose phosphate metabolic process | MF:nucleotide biosynthetic process [Term] id: NeXO:7728 name: CC: | BP: re-entry into mitotic cell cycle after pheromone arrest | MF: def: "CC_def: | BP_def: The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.1762546273728 density:0.964285714285714 bootstrap:0.78250238 cc_score:0.0 bp_score:0.325386 mf_score:0.0 relationship: child_of NeXO:8504 ! CC: | BP: re-entry into mitotic cell cycle | MF: [Term] id: NeXO:5319 name: CC: | BP: purine base salvage | MF:adenine phosphoribosyltransferase activity def: "CC_def: | BP_def: Any process that generates purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis. | MF_def:Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.25323332576107 density:1 bootstrap:0.84126763 cc_score:0.0 bp_score:0.204475 mf_score:0.2942 relationship: child_of NeXO:5493 ! CC: | BP: | MF:tRNA (guanine) methyltransferase activity [Term] id: NeXO:5318 name: CC: | BP: AMP biosynthetic process | MF:adenosine kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. | MF_def:Catalysis of the reaction: ATP + adenosine = ADP + AMP." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.69253875 cc_score:0.0 bp_score:0.2933 mf_score:0.446417 relationship: child_of NeXO:5459 ! CC: sulfite reductase complex (NADPH) | BP: purine ribonucleoside salvage | MF:sulfite reductase (NADPH) activity [Term] id: NeXO:5313 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.828866105 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5390 ! CC: | BP: | MF: [Term] id: NeXO:5312 name: CC: | BP: | MF:ethanolamine kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.839861594 cc_score:0.0 bp_score:0.0568931 mf_score:0.29183 relationship: child_of NeXO:6285 ! CC: | BP: | MF:1-acylglycerol-3-phosphate O-acyltransferase activity [Term] id: NeXO:5311 name: CC: | BP: wybutosine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.893474051 cc_score:0.0 bp_score:0.179963 mf_score:0.0 relationship: child_of NeXO:5368 ! CC: | BP: | MF: [Term] id: NeXO:5310 name: CC: | BP: histone H3-K36 demethylation | MF:methylated histone residue binding def: "CC_def: | BP_def: The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. | MF_def:Interacting selectively and non-covalently with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8743939 cc_score:0.0 bp_score:0.462545 mf_score:0.161547 relationship: child_of NeXO:5423 ! CC: | BP: histone demethylation | MF:histone demethylase activity (H3-K36 specific) [Term] id: NeXO:5317 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92689605 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5988 ! CC: | BP: | MF: [Term] id: NeXO:5316 name: CC: telomerase catalytic core complex | BP: telomerase activity | MF:telomeric template RNA reverse transcriptase activity def: "CC_def: The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. | BP_def: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. | MF_def:Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92722407 cc_score:0.300532 bp_score:0.178057 mf_score:0.442556 relationship: child_of NeXO:5467 ! CC: nuclear telomere cap complex | BP: negative regulation of telomere maintenance | MF:single-stranded telomeric DNA binding [Term] id: NeXO:5315 name: CC: | BP: carbohydrate phosphorylation | MF:galactokinase activity def: "CC_def: | BP_def: The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. | MF_def:Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.925492637 cc_score:0.0 bp_score:0.292199 mf_score:0.295286 relationship: child_of NeXO:7055 ! CC: | BP: galactose metabolic process | MF:UDP-glucose 4-epimerase activity [Term] id: NeXO:5314 name: CC: | BP: hyperosmotic salinity response | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87136753 cc_score:0.0 bp_score:0.126981 mf_score:0.0 relationship: child_of NeXO:6472 ! CC: | BP: | MF: [Term] id: NeXO:8804 name: CC: | BP: iron assimilation by chelation and transport | MF: def: "CC_def: | BP_def: A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.58581797819455 density:0.535714285714286 bootstrap:0.175850163 cc_score:0.0 bp_score:0.308294 mf_score:0.0 relationship: child_of NeXO:8905 ! CC: | BP: iron ion transport | MF:iron ion transmembrane transporter activity [Term] id: NeXO:9447 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.6302120505801 density:0.466666666666667 bootstrap:0.449310831 cc_score:0.0 bp_score:0.0636351 mf_score:0.0 relationship: child_of NeXO:9794 ! CC: | BP: protein localization in endoplasmic reticulum | MF: [Term] id: NeXO:8806 name: CC: | BP: negative regulation of transcription involved in G1/S phase of mitotic cell cycle | MF:fatty acid alpha-hydroxylase activity def: "CC_def: | BP_def: Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle. | MF_def:Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.560534437 cc_score:0.0 bp_score:0.439677 mf_score:0.437663 relationship: child_of NeXO:9311 ! CC: | BP: | MF: relationship: linked_to NeXO:8958 ! CC: | BP: | MF:protein complex scaffold [Term] id: NeXO:8807 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.20553875338236 density:0.8 bootstrap:0.609228123 cc_score:0.0 bp_score:0.0760836 mf_score:0.0 relationship: child_of NeXO:9763 ! CC: | BP: | MF: relationship: linked_to NeXO:9270 ! CC: | BP: | MF: [Term] id: NeXO:8800 name: CC: chaperonin-containing T-complex | BP: | MF: def: "CC_def: A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.10038837458815 density:0.611111111111111 bootstrap:0.7477651 cc_score:0.408659 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9579 ! CC: | BP: pentose biosynthetic process | MF: [Term] id: NeXO:8801 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.4481748894339 density:0.219576719576720 bootstrap:0.506803564 cc_score:0.0796423 bp_score:0.0800674 mf_score:0.0658711 relationship: child_of NeXO:9303 ! CC: | BP: | MF: [Term] id: NeXO:6368 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04777030894267 density:1 bootstrap:0.69483923 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6832 ! CC: | BP: | MF: [Term] id: NeXO:8803 name: CC: | BP: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery | MF: def: "CC_def: | BP_def: The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68635931 cc_score:0.0 bp_score:0.119019 mf_score:0.0 relationship: child_of NeXO:9052 ! CC: | BP: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery | MF: [Term] id: NeXO:9443 name: CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.66671263840957 density:0.666666666666667 bootstrap:0.331747787 cc_score:0.0 bp_score:0.0626336 mf_score:0.207604 relationship: child_of NeXO:9612 ! CC: | BP: GDP-mannose biosynthetic process | MF:mannose-1-phosphate guanylyltransferase activity [Term] id: NeXO:8809 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.34370206002165 density:0.05 bootstrap:0.162195781 cc_score:0.0 bp_score:0.0297382 mf_score:0.0 relationship: child_of NeXO:9585 ! CC: | BP: | MF: [Term] id: NeXO:6583 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.806353529 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6584 ! CC: | BP: | MF: [Term] id: NeXO:6582 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.33491675602416 density:0.238095238095238 bootstrap:0.548229147 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7233 ! CC: | BP: | MF: [Term] id: NeXO:6581 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.41669408639415 density:0.666666666666667 bootstrap:0.91001853 cc_score:0.0 bp_score:0.0 mf_score:0.0723013 relationship: child_of NeXO:6582 ! CC: | BP: | MF: [Term] id: NeXO:9112 name: CC: tight junction | BP: | MF: def: "CC_def: An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.3207149783147 density:1 bootstrap:0.609061828 cc_score:0.292136 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9329 ! CC: | BP: | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: relationship: linked_to NeXO:9327 ! CC: | BP: positive regulation of lipid biosynthetic process | MF: relationship: linked_to NeXO:8716 ! CC: | BP: | MF: [Term] id: NeXO:6587 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.04619962242259 density:0.333333333333333 bootstrap:0.847764185 cc_score:0.0 bp_score:0.0223132 mf_score:0.0 relationship: child_of NeXO:7318 ! CC: | BP: | MF: [Term] id: NeXO:6586 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72627299 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7820 ! CC: | BP: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:6585 name: CC: | BP: | MF:mRNA (N6-adenosine)-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.717838 cc_score:0.0 bp_score:0.0 mf_score:0.278958 relationship: child_of NeXO:7807 ! CC: | BP: | MF:mRNA methyltransferase activity [Term] id: NeXO:8209 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.61185093832783 density:0.117647058823529 bootstrap:0.5640899 cc_score:0.0 bp_score:0.0465445 mf_score:0.0 relationship: child_of NeXO:9404 ! CC: | BP: | MF: [Term] id: NeXO:8206 name: CC: | BP: | MF:biotin synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.68611833501927 density:0.333333333333333 bootstrap:0.57564557 cc_score:0.0 bp_score:0.0208983 mf_score:0.318439 relationship: child_of NeXO:8897 ! CC: | BP: | MF:radical SAM enzyme activity [Term] id: NeXO:8207 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.99107012128586 density:0.222222222222222 bootstrap:0.511923348 cc_score:0.0 bp_score:0.0635769 mf_score:0.0 relationship: child_of NeXO:9146 ! CC: | BP: glycoprotein biosynthetic process | MF:mannosyltransferase activity [Term] id: NeXO:6589 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92971934451878 density:0.333333333333333 bootstrap:0.75399309 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6736 ! CC: | BP: | MF: relationship: linked_to NeXO:7211 ! CC: | BP: | MF: [Term] id: NeXO:8205 name: CC: | BP: negative regulation of protein complex assembly | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.82698636967887 density:1 bootstrap:0.55308574 cc_score:0.0 bp_score:0.117369 mf_score:0.0 relationship: child_of NeXO:8692 ! CC: | BP: | MF: relationship: linked_to NeXO:8737 ! CC: | BP: | MF: [Term] id: NeXO:8750 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.37705360143186 density:0.214285714285714 bootstrap:0.241300108 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9459 ! CC: | BP: | MF: [Term] id: NeXO:8203 name: CC: | BP: positive regulation of Arp2/3 complex-mediated actin nucleation | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.453909508 cc_score:0.0698938 bp_score:0.441415 mf_score:0.0 relationship: child_of NeXO:8686 ! CC: actomyosin contractile ring | BP: negative regulation of Arp2/3 complex-mediated actin nucleation | MF:myosin II heavy chain binding [Term] id: NeXO:8752 name: CC: Noc4p-Nop14p complex | BP: | MF: def: "CC_def: A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.437404975 cc_score:0.231122 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9119 ! CC: | BP: | MF: [Term] id: NeXO:8753 name: CC: | BP: negative regulation of DNA damage checkpoint | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.98561872515088 density:1 bootstrap:0.87738394 cc_score:0.0 bp_score:0.878406 mf_score:0.0 relationship: child_of NeXO:9497 ! CC: | BP: signal transduction involved in meiotic recombination checkpoint | MF:translation repressor activity, nucleic acid binding relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:7625 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.2290155421462 density:0.5 bootstrap:0.72536546 cc_score:0.0 bp_score:0.0948492 mf_score:0.0 relationship: child_of NeXO:8586 ! CC: | BP: | MF: [Term] id: NeXO:7624 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.711816249 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7625 ! CC: | BP: | MF: [Term] id: NeXO:7627 name: CC: | BP: protein glutathionylation | MF:citrate transmembrane transporter activity def: "CC_def: | BP_def: The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. | MF_def:Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.517091827 cc_score:0.0 bp_score:0.29179 mf_score:0.448896 relationship: child_of NeXO:8143 ! CC: | BP: citrate transport | MF:tricarboxylic acid transmembrane transporter activity [Term] id: NeXO:7626 name: CC: | BP: | MF:mating-type factor pheromone receptor activity def: "CC_def: | BP_def: | MF_def:Combining with a mating-type factor pheromone to initiate a change in cell activity." [NeXO-GO:term] namespace: NeXO comment: robustness:1.56785970905075 density:0.166666666666667 bootstrap:0.57850038 cc_score:0.0 bp_score:0.096433 mf_score:0.164865 relationship: child_of NeXO:8538 ! CC: | BP: | MF:G-protein coupled receptor protein signaling pathway [Term] id: NeXO:7621 name: CC: | BP: | MF:box H/ACA snoRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with box H/ACA small nucleolar RNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.35418141209529 density:1 bootstrap:0.91833619 cc_score:0.0 bp_score:0.0324896 mf_score:0.443923 relationship: child_of NeXO:8946 ! CC: | BP: snRNA pseudouridine synthesis | MF: relationship: linked_to NeXO:9826 ! CC: | BP: regulation of telomerase activity | MF: relationship: linked_to NeXO:5514 ! CC: | BP: box H/ACA snoRNP assembly | MF: relationship: linked_to NeXO:9251 ! CC: | BP: | MF: [Term] id: NeXO:7620 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.498390628 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8485 ! CC: | BP: | MF: [Term] id: NeXO:7623 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.28900923066128 density:0.121212121212121 bootstrap:0.417134316 cc_score:0.0 bp_score:0.04474 mf_score:0.0 relationship: child_of NeXO:8792 ! CC: | BP: | MF: [Term] id: NeXO:7622 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.74761127251903 density:1 bootstrap:0.506071082 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8646 ! CC: | BP: | MF: relationship: linked_to NeXO:8358 ! CC: | BP: | MF:glucosaminyl-phosphotidylinositol O-acyltransferase activity [Term] id: NeXO:7192 name: CC: NatB complex | BP: N-terminal peptidyl-methionine acetylation | MF:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity def: "CC_def: A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. | BP_def: The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. | MF_def:Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.439005598 cc_score:0.296241 bp_score:0.22139 mf_score:0.221315 relationship: child_of NeXO:8229 ! CC: | BP: | MF:nitric oxide dioxygenase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:7629 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06523933015917 density:0.166666666666667 bootstrap:0.195742432 cc_score:0.0918667 bp_score:0.0921237 mf_score:0.0415456 relationship: child_of NeXO:8722 ! CC: | BP: | MF: [Term] id: NeXO:7628 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.60831482054424 density:0.127272727272727 bootstrap:0.56077008 cc_score:0.0 bp_score:0.0913973 mf_score:0.0967582 relationship: child_of NeXO:8447 ! CC: | BP: | MF: [Term] id: NeXO:5406 name: CC: | BP: | MF:dodecenoyl-CoA delta-isomerase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:3.63894356344519 density:0.5 bootstrap:0.87608937 cc_score:0.0 bp_score:0.0 mf_score:0.446885 relationship: child_of NeXO:6940 ! CC: | BP: fatty acid beta-oxidation | MF:intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: NeXO:5405 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.847949711 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6373 ! CC: | BP: protein-chromophore linkage | MF: [Term] id: NeXO:5404 name: CC: | BP: phosphatidylethanolamine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90454534 cc_score:0.0845439 bp_score:0.140574 mf_score:0.0 relationship: child_of NeXO:6069 ! CC: | BP: | MF: [Term] id: NeXO:5403 name: CC: tRNA-intron endonuclease complex | BP: tRNA-type intron splice site recognition and cleavage | MF:tRNA-intron endonuclease activity def: "CC_def: A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. | BP_def: RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. | MF_def:Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [NeXO-GO:term] namespace: NeXO comment: robustness:5.79898539497715 density:1 bootstrap:0.92868535 cc_score:0.875184 bp_score:0.882873 mf_score:0.888597 relationship: child_of NeXO:6573 ! CC: | BP: tRNA splicing, via endonucleolytic cleavage and ligation | MF:endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: NeXO:5402 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18183901673828 density:1 bootstrap:0.78880064 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6063 ! CC: | BP: | MF: [Term] id: NeXO:9455 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26546977248107 density:0.0251207729468599 bootstrap:0.12727205 cc_score:0.0 bp_score:0.0241314 mf_score:0.0227322 relationship: child_of NeXO:9673 ! CC: | BP: | MF: [Term] id: NeXO:5400 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06294205015211 density:0.666666666666667 bootstrap:0.85496926 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5997 ! CC: | BP: | MF: [Term] id: NeXO:5409 name: CC: | BP: movement of group I intron | MF: def: "CC_def: | BP_def: Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85115534 cc_score:0.0 bp_score:0.441523 mf_score:0.0 relationship: child_of NeXO:6526 ! CC: | BP: positive regulation of mitochondrial translation | MF:translation regulator activity [Term] id: NeXO:5408 name: CC: | BP: positive regulation of ubiquitin-protein ligase activity | MF:NEDD8 ligase activity def: "CC_def: | BP_def: Any process that activates, maintains or increases the rate of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. | MF_def:Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.710139 cc_score:0.0 bp_score:0.183494 mf_score:0.293167 relationship: child_of NeXO:6549 ! CC: | BP: protein neddylation | MF:small protein activating enzyme activity [Term] id: NeXO:6523 name: CC: | BP: late endosome to vacuole transport via multivesicular body sorting pathway | MF: def: "CC_def: | BP_def: The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.54390142227721 density:0.5 bootstrap:0.83092349 cc_score:0.0 bp_score:0.122111 mf_score:0.0 relationship: child_of NeXO:6738 ! CC: | BP: | MF: [Term] id: NeXO:5130 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8339748 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5379 ! CC: | BP: | MF: [Term] id: NeXO:7940 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.0836359468597 density:0.166666666666667 bootstrap:0.276347828 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8433 ! CC: | BP: | MF: [Term] id: NeXO:9804 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.9637519127615 density:0.45 bootstrap:0.527236094 cc_score:0.0 bp_score:0.0579986 mf_score:0.0 relationship: child_of NeXO:9886 ! CC: condensed nuclear chromosome kinetochore | BP: mitotic sister chromatid cohesion | MF: [Term] id: NeXO:8118 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.44975375683225 density:1 bootstrap:0.61305231 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8768 ! CC: | BP: | MF: relationship: linked_to NeXO:9825 ! CC: | BP: | MF: [Term] id: NeXO:8119 name: CC: mating projection base | BP: negative regulation of phosphatidylinositol biosynthetic process | MF: def: "CC_def: The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. | BP_def: Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.48401978 cc_score:0.125418 bp_score:0.441981 mf_score:0.0 relationship: child_of NeXO:8979 ! CC: | BP: ultradian rhythm | MF: relationship: linked_to NeXO:9471 ! CC: | BP: lipid tube assembly | MF: relationship: linked_to NeXO:7644 ! CC: | BP: | MF: [Term] id: NeXO:7233 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5840541527707 density:0.120879120879121 bootstrap:0.366233625 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8362 ! CC: | BP: snoRNA metabolic process | MF: [Term] id: NeXO:6928 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53527089 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8072 ! CC: | BP: | MF: [Term] id: NeXO:9878 name: CC: | BP: membrane docking | MF: def: "CC_def: | BP_def: The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.68707609587748 density:0.117241379310345 bootstrap:0.142332454 cc_score:0.0641503 bp_score:0.118283 mf_score:0.0 relationship: child_of NeXO:9941 ! CC: | BP: post-Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9879 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.3555773334311 density:0.976608187134503 bootstrap:0.410789378 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10004 ! CC: | BP: | MF: [Term] id: NeXO:9876 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.16301315616253 density:0.227941176470588 bootstrap:0.228123135 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9942 ! CC: | BP: | MF: [Term] id: NeXO:6924 name: CC: | BP: snoRNA localization | MF: def: "CC_def: | BP_def: Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.645226806 cc_score:0.0 bp_score:0.313216 mf_score:0.0 relationship: child_of NeXO:8127 ! CC: | BP: | MF: [Term] id: NeXO:8110 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.822979782 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8667 ! CC: | BP: | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: [Term] id: NeXO:9875 name: CC: UTP-C complex | BP: transcription elongation from RNA polymerase I promoter | MF:RNA polymerase II core binding def: "CC_def: A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. | BP_def: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. | MF_def:Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [NeXO-GO:term] namespace: NeXO comment: robustness:7.17409079604852 density:0.285714285714286 bootstrap:0.21473837 cc_score:0.132456 bp_score:0.207038 mf_score:0.149917 relationship: child_of NeXO:9972 ! CC: | BP: transcription-coupled nucleotide-excision repair | MF:core RNA polymerase II binding transcription factor activity [Term] id: NeXO:8116 name: CC: PAS complex | BP: positive regulation of kinase activity | MF:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity def: "CC_def: A protein complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. | BP_def: Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. | MF_def:Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:6.4596729361221 density:0.9 bootstrap:0.80220441 cc_score:0.451156 bp_score:0.127947 mf_score:0.100064 relationship: child_of NeXO:8404 ! CC: | BP: | MF: [Term] id: NeXO:9873 name: CC: | BP: spindle pole body separation | MF:cyclin-dependent protein kinase activity def: "CC_def: | BP_def: A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble. | MF_def:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [NeXO-GO:term] namespace: NeXO comment: robustness:7.63265940853411 density:0.252380952380952 bootstrap:0.285025042 cc_score:0.0 bp_score:0.175163 mf_score:0.114712 relationship: child_of NeXO:9917 ! CC: | BP: G-protein coupled receptor protein signaling pathway | MF: [Term] id: NeXO:9870 name: CC: | BP: glucose catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.8031146292799 density:0.0968253968253968 bootstrap:0.268945463 cc_score:0.085957 bp_score:0.126728 mf_score:0.0387417 relationship: child_of NeXO:9962 ! CC: | BP: modification-dependent protein catabolic process | MF: [Term] id: NeXO:9871 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.71771263527952 density:0.0414486921529175 bootstrap:0.110228056 cc_score:0.0 bp_score:0.0878056 mf_score:0.0211809 relationship: child_of NeXO:9930 ! CC: | BP: | MF: [Term] id: NeXO:7711 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.273272699 cc_score:0.0 bp_score:0.0 mf_score:0.0492851 relationship: child_of NeXO:8259 ! CC: | BP: | MF: relationship: linked_to NeXO:8106 ! CC: | BP: | MF:4-alpha-glucanotransferase activity relationship: linked_to NeXO:7923 ! CC: | BP: | MF: [Term] id: NeXO:7710 name: CC: | BP: deoxyribonucleotide biosynthetic process | MF:oxidoreductase activity, acting on CH or CH2 groups def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [NeXO-GO:term] namespace: NeXO comment: robustness:7.51536735130139 density:0.363636363636364 bootstrap:0.64972096 cc_score:0.0 bp_score:0.198139 mf_score:0.270753 relationship: child_of NeXO:7867 ! CC: | BP: deoxyribonucleotide metabolic process | MF: [Term] id: NeXO:5548 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.753946829 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6599 ! CC: | BP: | MF: [Term] id: NeXO:5549 name: CC: | BP: nitrogen catabolite activation of transcription from RNA polymerase II promoter | MF:ureidoglycolate hydrolase activity def: "CC_def: | BP_def: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. | MF_def:Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.773167936 cc_score:0.0 bp_score:0.225069 mf_score:0.448451 relationship: child_of NeXO:6567 ! CC: | BP: allantoate transport | MF:allantoate transmembrane transporter activity [Term] id: NeXO:7714 name: CC: | BP: protein localization at cell surface | MF: def: "CC_def: | BP_def: A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.59722331 cc_score:0.0 bp_score:0.437854 mf_score:0.0 relationship: child_of NeXO:8657 ! CC: | BP: | MF:cAMP-dependent protein kinase regulator activity [Term] id: NeXO:7717 name: CC: | BP: actin filament-based movement | MF: def: "CC_def: | BP_def: Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.84722723134487 density:0.166666666666667 bootstrap:0.80302653 cc_score:0.0 bp_score:0.142131 mf_score:0.0 relationship: child_of NeXO:8776 ! CC: | BP: | MF: [Term] id: NeXO:7716 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.602339763 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8356 ! CC: TORC1 complex | BP: | MF: relationship: linked_to NeXO:6460 ! CC: TORC2 complex | BP: | MF: [Term] id: NeXO:7719 name: CC: calcineurin complex | BP: | MF:calcium-dependent protein serine/threonine phosphatase activity def: "CC_def: A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. | BP_def: | MF_def:Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20265961577808 density:1 bootstrap:0.80392702 cc_score:0.586456 bp_score:0.0354348 mf_score:0.440708 relationship: child_of NeXO:8787 ! CC: | BP: | MF: relationship: linked_to NeXO:6009 ! CC: | BP: | MF: [Term] id: NeXO:7718 name: CC: | BP: telomere localization | MF: def: "CC_def: | BP_def: Any process in which a telomere is transported to, and/or maintained in, a specific location. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5451913887847 density:0.166666666666667 bootstrap:0.576797776 cc_score:0.0 bp_score:0.108482 mf_score:0.0934272 relationship: child_of NeXO:8985 ! CC: | BP: | MF: [Term] id: NeXO:6444 name: CC: | BP: glucokinase activity | MF:pentaerythritol trinitrate reductase activity def: "CC_def: | BP_def: Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. | MF_def:Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.563028727 cc_score:0.0 bp_score:0.291667 mf_score:0.299265 relationship: child_of NeXO:7443 ! CC: | BP: | MF:glutamate-5-semialdehyde dehydrogenase activity [Term] id: NeXO:5541 name: CC: | BP: lipid storage | MF:diacylglycerol O-acyltransferase activity def: "CC_def: | BP_def: The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. | MF_def:Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:2.07037736039118 density:1 bootstrap:0.71026574 cc_score:0.0 bp_score:0.879055 mf_score:0.44745 relationship: child_of NeXO:5724 ! CC: | BP: triglyceride biosynthetic process | MF:phospholipid:diacylglycerol acyltransferase activity [Term] id: NeXO:5546 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.04984662740917 density:0.666666666666667 bootstrap:0.84767415 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5786 ! CC: | BP: | MF: [Term] id: NeXO:5547 name: CC: | BP: homocysteine catabolic process | MF:adenosylhomocysteinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. | MF_def:Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.507131586 cc_score:0.0 bp_score:0.443572 mf_score:0.446999 relationship: child_of NeXO:5743 ! CC: | BP: selenocysteine metabolic process | MF:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [Term] id: NeXO:5544 name: CC: | BP: riboflavin transport | MF:riboflavin transporter activity def: "CC_def: | BP_def: The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. | MF_def:Facilitates the directed movement of riboflavin into, out of or within a cell, or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [NeXO-GO:term] namespace: NeXO comment: robustness:2.30050163245246 density:1 bootstrap:0.87693406 cc_score:0.0 bp_score:0.44073 mf_score:0.444433 relationship: child_of NeXO:6059 ! CC: | BP: | MF:vitamin transporter activity [Term] id: NeXO:5545 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76476161 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5546 ! CC: | BP: | MF: [Term] id: NeXO:5168 name: CC: negative cofactor 2 complex | BP: | MF: def: "CC_def: A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39155005606196 density:1 bootstrap:0.94772164 cc_score:0.899499 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6680 ! CC: | BP: siderophore metabolic process | MF: [Term] id: NeXO:7127 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02584925012212 density:1 bootstrap:0.680042565 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7183 ! CC: | BP: | MF: relationship: linked_to NeXO:8104 ! CC: | BP: mitochondrial proton-transporting ATP synthase complex assembly | MF: [Term] id: NeXO:8599 name: CC: | BP: N-terminal protein amino acid modification | MF: def: "CC_def: | BP_def: The alteration of the N-terminal amino acid residue in a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.3227903049349 density:0.0606060606060606 bootstrap:0.162455876 cc_score:0.0 bp_score:0.166147 mf_score:0.0 relationship: child_of NeXO:9441 ! CC: | BP: | MF: [Term] id: NeXO:8597 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.0580720059941 density:0.730769230769231 bootstrap:0.85681729 cc_score:0.0 bp_score:0.0781973 mf_score:0.0 relationship: child_of NeXO:8738 ! CC: | BP: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | MF: [Term] id: NeXO:8594 name: CC: | BP: regulation of invasive growth in response to glucose limitation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.18017085738786 density:0.4 bootstrap:0.53781873 cc_score:0.0 bp_score:0.420296 mf_score:0.0 relationship: child_of NeXO:9440 ! CC: | BP: regulation of pseudohyphal growth | MF: [Term] id: NeXO:8592 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7444550452687 density:1 bootstrap:0.50424478 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9354 ! CC: | BP: | MF: relationship: linked_to NeXO:9152 ! CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: relationship: linked_to NeXO:7860 ! CC: | BP: protein localization to kinetochore | MF: [Term] id: NeXO:8593 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.270843631 cc_score:0.0 bp_score:0.0200899 mf_score:0.0566575 relationship: child_of NeXO:9283 ! CC: | BP: | MF: [Term] id: NeXO:8590 name: CC: Ndc80 complex | BP: | MF: def: "CC_def: A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.2076597036968 density:0.7 bootstrap:0.72387614 cc_score:0.633263 bp_score:0.0219493 mf_score:0.0 relationship: child_of NeXO:9835 ! CC: spindle pole body | BP: microtubule nucleation | MF:structural constituent of cytoskeleton [Term] id: NeXO:8591 name: CC: intermediate filament | BP: intermediate filament-based process | MF: def: "CC_def: A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. | BP_def: Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.55522183763533 density:1 bootstrap:0.400780459 cc_score:0.292078 bp_score:0.437611 mf_score:0.0 relationship: child_of NeXO:9147 ! CC: spindle midzone | BP: mitotic spindle stabilization | MF: relationship: linked_to NeXO:8201 ! CC: | BP: | MF: [Term] id: NeXO:8376 name: CC: Nup107-160 complex | BP: snRNA export from nucleus | MF: def: "CC_def: A subcomplex of the nuclear pore complex (NPC) involved in mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p. | BP_def: The directed movement of snRNA from the nucleus to the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.35082611525815 density:1 bootstrap:0.79068999 cc_score:0.503246 bp_score:0.264569 mf_score:0.0 relationship: child_of NeXO:9416 ! CC: | BP: ribosomal protein import into nucleus | MF:protein export from nucleus relationship: linked_to NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: [Term] id: NeXO:8377 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.22196175757056 density:1 bootstrap:0.75306409 cc_score:0.0 bp_score:0.0205094 mf_score:0.0 relationship: child_of NeXO:8800 ! CC: chaperonin-containing T-complex | BP: | MF: [Term] id: NeXO:8374 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.99431816475427 density:0.133333333333333 bootstrap:0.195179623 cc_score:0.0 bp_score:0.0749255 mf_score:0.0 relationship: child_of NeXO:9146 ! CC: | BP: glycoprotein biosynthetic process | MF:mannosyltransferase activity [Term] id: NeXO:8375 name: CC: | BP: arsenite transport | MF:arsenite transport def: "CC_def: | BP_def: The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.56196153 cc_score:0.0 bp_score:0.231193 mf_score:0.219136 relationship: child_of NeXO:9531 ! CC: | BP: | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: [Term] id: NeXO:8372 name: CC: | BP: establishment of chromatin silencing | MF: def: "CC_def: | BP_def: The initial formation of a transcriptionally silent chromatin structure such as heterochromatin. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11912126181417 density:1 bootstrap:0.744103701 cc_score:0.0 bp_score:0.292802 mf_score:0.0 relationship: child_of NeXO:9200 ! CC: | BP: | MF: relationship: linked_to NeXO:9700 ! CC: pre-replicative complex | BP: progressive alteration of chromatin involved in replicative cell aging | MF: [Term] id: NeXO:8370 name: CC: | BP: positive regulation of translational initiation | MF:translation initiation factor binding def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of translational initiation. | MF_def:Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [NeXO-GO:term] namespace: NeXO comment: robustness:4.98305720346585 density:1 bootstrap:0.68573499 cc_score:0.0 bp_score:0.294255 mf_score:0.292605 relationship: child_of NeXO:8717 ! CC: | BP: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | MF: [Term] id: NeXO:8371 name: CC: | BP: copper ion import | MF:oxidoreductase activity, oxidizing metal ions def: "CC_def: | BP_def: The directed movement of copper ions into a cell or organelle. | MF_def:Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [NeXO-GO:term] namespace: NeXO comment: robustness:4.27810029543464 density:0.392857142857143 bootstrap:0.369427259 cc_score:0.0 bp_score:0.265017 mf_score:0.137653 relationship: child_of NeXO:8905 ! CC: | BP: iron ion transport | MF:iron ion transmembrane transporter activity [Term] id: NeXO:8378 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.58190329815535 density:0.444444444444444 bootstrap:0.58624038 cc_score:0.0 bp_score:0.0769091 mf_score:0.0 relationship: child_of NeXO:9370 ! CC: | BP: | MF: [Term] id: NeXO:8379 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.75209844953746 density:0.666666666666667 bootstrap:0.27976279 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8693 ! CC: | BP: | MF: relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity [Term] id: NeXO:8574 name: CC: | BP: respiratory chain complex IV assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.36233636171222 density:0.0294117647058824 bootstrap:0.233049726 cc_score:0.0667906 bp_score:0.109314 mf_score:0.0 relationship: child_of NeXO:8820 ! CC: | BP: mitochondrial respiratory chain complex IV biogenesis | MF: [Term] id: NeXO:5891 name: CC: | BP: response to hydrogen peroxide | MF:glucose-6-phosphate dehydrogenase activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. | MF_def:Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.1604336639861 density:1 bootstrap:0.7733992 cc_score:0.0 bp_score:0.127274 mf_score:0.43807 relationship: child_of NeXO:5892 ! CC: | BP: pyrimidine ribonucleotide biosynthetic process | MF:UMP biosynthetic process [Term] id: NeXO:5892 name: CC: | BP: pyrimidine ribonucleotide biosynthetic process | MF:UMP biosynthetic process def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. | MF_def:The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.76814639282876 density:0.178571428571429 bootstrap:0.409204068 cc_score:0.0 bp_score:0.123457 mf_score:0.154995 relationship: child_of NeXO:6376 ! CC: | BP: | MF:L-leucine transaminase activity [Term] id: NeXO:5893 name: CC: | BP: positive regulation of chromatin silencing at rDNA | MF:mRNA (guanine-N7-)-methyltransferase activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of chromatin silencing at rDNA. | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72064266 cc_score:0.0 bp_score:0.442809 mf_score:0.446487 relationship: child_of NeXO:6202 ! CC: | BP: negative regulation of histone deacetylation | MF:negative regulation of histone deacetylation [Term] id: NeXO:5894 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83603084 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7648 ! CC: | BP: | MF: [Term] id: NeXO:5895 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.746006973 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7181 ! CC: | BP: | MF: [Term] id: NeXO:8572 name: CC: | BP: purine base biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.67677121489079 density:0.115384615384615 bootstrap:0.251092796 cc_score:0.0 bp_score:0.108566 mf_score:0.0 relationship: child_of NeXO:9252 ! CC: | BP: purine ribonucleoside monophosphate biosynthetic process | MF: [Term] id: NeXO:8573 name: CC: mitochondrial respiratory chain complex IV | BP: mitochondrial electron transport, cytochrome c to oxygen | MF:cytochrome-c oxidase activity def: "CC_def: A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). | BP_def: The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. | MF_def:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:4.48754143105451 density:1 bootstrap:0.556136638 cc_score:0.202956 bp_score:0.204541 mf_score:0.133025 relationship: child_of NeXO:8820 ! CC: | BP: mitochondrial respiratory chain complex IV biogenesis | MF: [Term] id: NeXO:9197 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.71919596459323 density:0.866666666666667 bootstrap:0.611687545 cc_score:0.0 bp_score:0.0664004 mf_score:0.0373667 relationship: child_of NeXO:9724 ! CC: | BP: | MF: relationship: linked_to NeXO:8400 ! CC: | BP: | MF: [Term] id: NeXO:5899 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.805995234 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6838 ! CC: fungal-type vacuole lumen | BP: | MF:metallocarboxypeptidase activity [Term] id: NeXO:8578 name: CC: TFIIK complex | BP: | MF: def: "CC_def: A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces, TFIIK contains Ccl1p, Tfb3p and Kin2p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.64675194086931 density:0.833333333333333 bootstrap:0.76067719 cc_score:0.628028 bp_score:0.0 mf_score:0.0404794 relationship: child_of NeXO:8913 ! CC: holo TFIIH complex | BP: phosphorylation of RNA polymerase II C-terminal domain | MF: [Term] id: NeXO:9801 name: CC: SAGA-type complex | BP: internal peptidyl-lysine acetylation | MF:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity def: "CC_def: A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. | BP_def: The addition of an acetyl group to a non-terminal lysine residue in a protein. | MF_def:Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [NeXO-GO:term] namespace: NeXO comment: robustness:24.4241095439812 density:0.684782608695652 bootstrap:0.81353933 cc_score:0.448558 bp_score:0.188851 mf_score:0.345949 relationship: child_of NeXO:9988 ! CC: DNA-directed RNA polymerase II, holoenzyme | BP: RNA polymerase II transcriptional preinitiation complex assembly | MF:RNA polymerase II transcriptional preinitiation complex assembly [Term] id: NeXO:5769 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83668107 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6552 ! CC: | BP: | MF: [Term] id: NeXO:7408 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.665658496 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8374 ! CC: | BP: | MF: [Term] id: NeXO:7404 name: CC: | BP: nitrogen catabolite repression of transcription | MF: def: "CC_def: | BP_def: A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.90357503564612 density:1 bootstrap:0.60042926 cc_score:0.0 bp_score:0.231057 mf_score:0.0 relationship: child_of NeXO:8111 ! CC: | BP: nitrogen catabolite regulation of transcription | MF:gamma-aminobutyric acid:hydrogen symporter activity relationship: linked_to NeXO:6567 ! CC: | BP: allantoate transport | MF:allantoate transmembrane transporter activity relationship: linked_to NeXO:8345 ! CC: | BP: allantoin catabolic process | MF:urea carboxylase activity relationship: linked_to NeXO:8487 ! CC: | BP: nitrate assimilation | MF: [Term] id: NeXO:7401 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39921557732781 density:0.111111111111111 bootstrap:0.435490667 cc_score:0.0 bp_score:0.063112 mf_score:0.0 relationship: child_of NeXO:8385 ! CC: | BP: | MF: [Term] id: NeXO:7400 name: CC: | BP: negative regulation of protein ubiquitination | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.87026508442535 density:0.666666666666667 bootstrap:0.750787366 cc_score:0.0 bp_score:0.102144 mf_score:0.0 relationship: child_of NeXO:7720 ! CC: | BP: | MF: [Term] id: NeXO:7403 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.85600639208288 density:0.109090909090909 bootstrap:0.426416961 cc_score:0.0 bp_score:0.0237903 mf_score:0.0 relationship: child_of NeXO:8685 ! CC: | BP: | MF: [Term] id: NeXO:7402 name: CC: | BP: snRNA processing | MF:ATP-dependent 5'-3' RNA helicase activity def: "CC_def: | BP_def: Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. | MF_def:Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'." [NeXO-GO:term] namespace: NeXO comment: robustness:2.19720008735517 density:1 bootstrap:0.79994672 cc_score:0.0 bp_score:0.136228 mf_score:0.438557 relationship: child_of NeXO:8176 ! CC: | BP: transcription termination, DNA-dependent | MF: [Term] id: NeXO:9800 name: CC: SLIK (SAGA-like) complex | BP: histone acetylation | MF: def: "CC_def: A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction. | BP_def: The modification of a histone by the addition of an acetyl group. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.8094945864231 density:0.491228070175439 bootstrap:0.810038002 cc_score:0.27081 bp_score:0.125198 mf_score:0.0424097 relationship: child_of NeXO:9801 ! CC: SAGA-type complex | BP: internal peptidyl-lysine acetylation | MF:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [Term] id: NeXO:5766 name: CC: | BP: DNA biosynthetic process | MF: def: "CC_def: | BP_def: The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.79762414115624 density:0.266666666666667 bootstrap:0.85123354 cc_score:0.0 bp_score:0.148162 mf_score:0.0 relationship: child_of NeXO:6296 ! CC: | BP: maintenance of DNA repeat elements | MF: [Term] id: NeXO:9874 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1937508783027 density:0.112375533428165 bootstrap:0.115122843 cc_score:0.0 bp_score:0.0671947 mf_score:0.0 relationship: child_of NeXO:9978 ! CC: | BP: | MF: [Term] id: NeXO:8560 name: CC: | BP: | MF:rRNA (adenine-N6,N6-)-dimethyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [NeXO-GO:term] namespace: NeXO comment: robustness:6.6667493844225 density:0.9 bootstrap:0.854461 cc_score:0.0 bp_score:0.0216164 mf_score:0.169659 relationship: child_of NeXO:9379 ! CC: | BP: | MF: [Term] id: NeXO:6628 name: CC: | BP: heterotrimeric G-protein complex cycle | MF:mating-type alpha-factor pheromone receptor activity def: "CC_def: | BP_def: The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits. | MF_def:Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.793368961 cc_score:0.0 bp_score:0.221271 mf_score:0.44873 relationship: child_of NeXO:7626 ! CC: | BP: | MF:mating-type factor pheromone receptor activity relationship: linked_to NeXO:8954 ! CC: | BP: regulation of transposition, RNA-mediated | MF:positive regulation of signal transduction [Term] id: NeXO:6700 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85345145 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7882 ! CC: | BP: | MF: [Term] id: NeXO:6626 name: CC: | BP: nitrogen catabolite activation of transcription | MF: def: "CC_def: | BP_def: A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10214566294515 density:1 bootstrap:0.7322299 cc_score:0.0 bp_score:0.204074 mf_score:0.0 relationship: child_of NeXO:8111 ! CC: | BP: nitrogen catabolite regulation of transcription | MF:gamma-aminobutyric acid:hydrogen symporter activity relationship: linked_to NeXO:8487 ! CC: | BP: nitrate assimilation | MF: [Term] id: NeXO:6627 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29106396242709 density:1 bootstrap:0.86975368 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7220 ! CC: | BP: | MF: [Term] id: NeXO:6624 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.94471536 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7845 ! CC: | BP: | MF: [Term] id: NeXO:6622 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.76213635910524 density:0.333333333333333 bootstrap:0.628721178 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6824 ! CC: | BP: | MF: [Term] id: NeXO:6623 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19246757841199 density:1 bootstrap:0.79650445 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8324 ! CC: | BP: | MF: [Term] id: NeXO:6620 name: CC: | BP: peptidyl-histidine phosphorylation | MF:two-component sensor activity def: "CC_def: | BP_def: The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). | MF_def:Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81214849 cc_score:0.0 bp_score:0.295246 mf_score:0.294184 relationship: child_of NeXO:7399 ! CC: | BP: peptidyl-serine phosphorylation | MF:pyruvate dehydrogenase (acetyl-transferring) kinase activity relationship: linked_to NeXO:7542 ! CC: mitochondrial pyruvate dehydrogenase complex | BP: acetyl-CoA biosynthetic process from pyruvate | MF:pyruvate dehydrogenase (acetyl-transferring) activity [Term] id: NeXO:6621 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68055163 cc_score:0.0 bp_score:0.0888476 mf_score:0.0744507 relationship: child_of NeXO:6622 ! CC: | BP: | MF: [Term] id: NeXO:6702 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72053643 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7639 ! CC: | BP: | MF: relationship: linked_to NeXO:8614 ! CC: | BP: protein import into peroxisome matrix, docking | MF:peroxisome matrix targeting signal-1 binding [Term] id: NeXO:5767 name: CC: | BP: establishment of protein localization in plasma membrane | MF: def: "CC_def: | BP_def: The directed movement of a protein to a specific location in the plasma membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.92911444 cc_score:0.0 bp_score:0.179914 mf_score:0.0898327 relationship: child_of NeXO:6177 ! CC: | BP: receptor-mediated endocytosis | MF:receptor-mediated endocytosis [Term] id: NeXO:8321 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.1615078941898 density:0.666666666666667 bootstrap:0.425781308 cc_score:0.0 bp_score:0.0177223 mf_score:0.0 relationship: child_of NeXO:9189 ! CC: | BP: | MF: relationship: linked_to NeXO:7518 ! CC: | BP: peptidyl-diphthamide biosynthetic process from peptidyl-histidine | MF: [Term] id: NeXO:8320 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.44046772621964 density:0.333333333333333 bootstrap:0.420132356 cc_score:0.0 bp_score:0.0 mf_score:0.0456627 relationship: child_of NeXO:8860 ! CC: | BP: protein sumoylation | MF: [Term] id: NeXO:9894 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3623641165801 density:0.0333138515488019 bootstrap:0.055299775 cc_score:0.0 bp_score:0.042548 mf_score:0.0142885 relationship: child_of NeXO:9974 ! CC: | BP: | MF: [Term] id: NeXO:9895 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.93062322377258 density:0.00938392492860057 bootstrap:0.096101664 cc_score:0.0245955 bp_score:0.0387414 mf_score:0.0303182 relationship: child_of NeXO:9952 ! CC: | BP: | MF: [Term] id: NeXO:9896 name: CC: | BP: pheromone-dependent signal transduction involved in conjugation with cellular fusion | MF:receptor signaling protein activity def: "CC_def: | BP_def: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. | MF_def:Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [NeXO-GO:term] namespace: NeXO comment: robustness:11.3791646896267 density:0.444444444444444 bootstrap:0.376080698 cc_score:0.0680084 bp_score:0.1775 mf_score:0.145537 relationship: child_of NeXO:9917 ! CC: | BP: G-protein coupled receptor protein signaling pathway | MF: [Term] id: NeXO:9897 name: CC: | BP: regulation of ubiquitin-protein ligase activity | MF:amino acid binding def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. | MF_def:Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [NeXO-GO:term] namespace: NeXO comment: robustness:3.12050915405793 density:0.476190476190476 bootstrap:0.204561658 cc_score:0.0 bp_score:0.198853 mf_score:0.124151 relationship: child_of NeXO:9975 ! CC: | BP: regulation of ligase activity | MF: relationship: linked_to NeXO:9622 ! CC: | BP: positive regulation of spindle pole body separation | MF: [Term] id: NeXO:9890 name: CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: def: "CC_def: A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. | BP_def: A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:23.1081036052114 density:0.436862745098039 bootstrap:0.72823188 cc_score:0.360723 bp_score:0.299722 mf_score:0.0463394 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: [Term] id: NeXO:9891 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.05360710584175 density:0.861111111111111 bootstrap:0.285491675 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:10004 ! CC: | BP: | MF: relationship: linked_to NeXO:9793 ! CC: | BP: | MF: relationship: linked_to NeXO:9816 ! CC: | BP: | MF: [Term] id: NeXO:6706 name: CC: ribonuclease MRP complex | BP: mRNA cleavage | MF:ribonuclease MRP activity def: "CC_def: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. | BP_def: Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. | MF_def:Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:11.9892048561827 density:0.618181818181818 bootstrap:0.84112415 cc_score:0.535259 bp_score:0.240288 mf_score:0.535865 relationship: child_of NeXO:6708 ! CC: | BP: snoRNA processing | MF:urea transmembrane transporter activity [Term] id: NeXO:9898 name: CC: | BP: cellular response to abiotic stimulus | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.08944932484959 density:0.0708898944193062 bootstrap:0.158376345 cc_score:0.0 bp_score:0.118954 mf_score:0.0222151 relationship: child_of NeXO:9948 ! CC: | BP: response to osmotic stress | MF: [Term] id: NeXO:9899 name: CC: | BP: DNA damage checkpoint | MF:double-stranded DNA binding def: "CC_def: | BP_def: A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. | MF_def:Interacting selectively and non-covalently with double-stranded DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:7.00581341276564 density:0.203076923076923 bootstrap:0.206322551 cc_score:0.034017 bp_score:0.125798 mf_score:0.12776 relationship: child_of NeXO:10013 ! CC: chromosome | BP: chromatin organization | MF:DNA binding [Term] id: NeXO:7563 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15097824583774 density:0.666666666666667 bootstrap:0.421643079 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7660 ! CC: | BP: | MF: [Term] id: NeXO:9571 name: CC: | BP: DNA damage induced protein phosphorylation | MF:histone phosphorylation def: "CC_def: | BP_def: The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage. | MF_def:The modification of histones by addition of phosphate groups." [NeXO-GO:term] namespace: NeXO comment: robustness:4.68710434620091 density:1 bootstrap:0.60669974 cc_score:0.0 bp_score:0.438423 mf_score:0.350421 relationship: child_of NeXO:9810 ! CC: | BP: histone phosphorylation | MF: relationship: linked_to NeXO:9494 ! CC: checkpoint clamp complex | BP: mitotic cell cycle G1/S transition checkpoint | MF:exodeoxyribonuclease III activity [Term] id: NeXO:5764 name: CC: | BP: pyridoxine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.21098908276403 density:0.6 bootstrap:0.84207584 cc_score:0.0 bp_score:0.440318 mf_score:0.0 relationship: child_of NeXO:7436 ! CC: | BP: vitamin B6 biosynthetic process | MF: [Term] id: NeXO:6409 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64147999 cc_score:0.0 bp_score:0.0783062 mf_score:0.0 relationship: child_of NeXO:7410 ! CC: | BP: | MF:nitric oxide reductase activity relationship: linked_to NeXO:9009 ! CC: | BP: heteroduplex formation | MF:recombinase activity [Term] id: NeXO:5823 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81185297 cc_score:0.0 bp_score:0.0163017 mf_score:0.0 relationship: child_of NeXO:7195 ! CC: | BP: | MF: [Term] id: NeXO:9915 name: CC: DNA-directed RNA polymerase complex | BP: polyadenylation-dependent mRNA catabolic process | MF:nucleotidyltransferase activity def: "CC_def: A protein complex that possesses DNA-directed RNA polymerase activity. | BP_def: The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. | MF_def:Catalysis of the transfer of a nucleotidyl group to a reactant." [NeXO-GO:term] namespace: NeXO comment: robustness:15.2842040286696 density:0.186507936507937 bootstrap:0.31858603 cc_score:0.248651 bp_score:0.296648 mf_score:0.110141 relationship: child_of NeXO:9973 ! CC: | BP: polyadenylation-dependent RNA catabolic process | MF: [Term] id: NeXO:9914 name: CC: | BP: regulation of tRNA export from nucleus | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of tRNA export from nucleus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.255356928 cc_score:0.028433 bp_score:0.169431 mf_score:0.0 relationship: child_of NeXO:9975 ! CC: | BP: regulation of ligase activity | MF: [Term] id: NeXO:6996 name: CC: | BP: | MF:acetyl-CoA carboxylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.771826001 cc_score:0.0 bp_score:0.0 mf_score:0.172652 relationship: child_of NeXO:7647 ! CC: | BP: meiotic joint molecule formation | MF: [Term] id: NeXO:6132 name: CC: | BP: positive regulation of fatty acid beta-oxidation | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30935580460705 density:1 bootstrap:0.883697339 cc_score:0.0 bp_score:0.58865 mf_score:0.0441635 relationship: child_of NeXO:7641 ! CC: | BP: positive regulation of fatty acid metabolic process | MF:catalase activity relationship: linked_to NeXO:6831 ! CC: | BP: | MF: [Term] id: NeXO:6133 name: CC: mitochondrial crista | BP: protein import into mitochondrial intermembrane space | MF: def: "CC_def: Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. | BP_def: The import of proteins into the space between the inner and outer mitochondrial membranes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.771169302 cc_score:0.219001 bp_score:0.110195 mf_score:0.0 relationship: child_of NeXO:6134 ! CC: | BP: | MF: [Term] id: NeXO:6130 name: CC: nuclear inner membrane | BP: | MF: def: "CC_def: The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.21652340653956 density:0.333333333333333 bootstrap:0.80129262 cc_score:0.155693 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7652 ! CC: | BP: | MF: [Term] id: NeXO:6131 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71522075 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6411 ! CC: | BP: | MF: [Term] id: NeXO:6136 name: CC: | BP: cellular zinc ion homeostasis | MF:ribosylnicotinamide kinase activity def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell. | MF_def:Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [NeXO-GO:term] namespace: NeXO comment: robustness:3.20542753717957 density:0.142857142857143 bootstrap:0.72056895 cc_score:0.0 bp_score:0.105571 mf_score:0.102284 relationship: child_of NeXO:7664 ! CC: | BP: | MF: [Term] id: NeXO:6137 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.25002017914076 density:0.2 bootstrap:0.611707626 cc_score:0.0 bp_score:0.0103478 mf_score:0.0 relationship: child_of NeXO:6577 ! CC: | BP: peptidyl-histidine methylation, to form tele-methylhistidine | MF:protein-histidine N-methyltransferase activity [Term] id: NeXO:6134 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.86057040360997 density:0.666666666666667 bootstrap:0.745724174 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6364 ! CC: | BP: | MF: [Term] id: NeXO:6135 name: CC: | BP: establishment of protein localization in membrane | MF: def: "CC_def: | BP_def: The directed movement of a protein to a specific location in a membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.516440919 cc_score:0.0 bp_score:0.13176 mf_score:0.0 relationship: child_of NeXO:6850 ! CC: | BP: | MF: [Term] id: NeXO:6034 name: CC: | BP: calcium ion transmembrane transport | MF:calcium-transporting ATPase activity def: "CC_def: | BP_def: A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81961566 cc_score:0.0 bp_score:0.178598 mf_score:0.295582 relationship: child_of NeXO:6180 ! CC: | BP: | MF: [Term] id: NeXO:5762 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80347349 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7504 ! CC: | BP: | MF: [Term] id: NeXO:9204 name: CC: | BP: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | MF:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity def: "CC_def: | BP_def: The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response. | MF_def:Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [NeXO-GO:term] namespace: NeXO comment: robustness:8.2429179765417 density:1 bootstrap:0.75054313 cc_score:0.0 bp_score:0.14811 mf_score:0.149835 relationship: child_of NeXO:9710 ! CC: | BP: oligosaccharide biosynthetic process | MF: relationship: linked_to NeXO:9584 ! CC: | BP: | MF: relationship: linked_to NeXO:9822 ! CC: | BP: | MF: [Term] id: NeXO:6446 name: CC: | BP: cellular modified amino acid catabolic process | MF:omega peptidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. | MF_def:Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.6594047284021 density:0.2 bootstrap:0.854554847 cc_score:0.0 bp_score:0.204519 mf_score:0.225871 relationship: child_of NeXO:7836 ! CC: | BP: peptide catabolic process | MF: [Term] id: NeXO:9473 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.02828962421508 density:0.00553709856035437 bootstrap:0.393634524 cc_score:0.0 bp_score:0.083202 mf_score:0.0476582 relationship: child_of NeXO:9922 ! CC: | BP: | MF: [Term] id: NeXO:9470 name: CC: | BP: | MF:voltage-gated calcium channel activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [NeXO-GO:term] namespace: NeXO comment: robustness:5.76921008744342 density:1 bootstrap:0.55149769 cc_score:0.0 bp_score:0.0581031 mf_score:0.178941 relationship: child_of NeXO:9584 ! CC: | BP: | MF: relationship: linked_to NeXO:9204 ! CC: | BP: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | MF:dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity relationship: linked_to NeXO:9376 ! CC: | BP: regulation of fungal-type cell wall organization | MF: [Term] id: NeXO:9471 name: CC: | BP: lipid tube assembly | MF: def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as the fuse or undergo fission. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.56609002117713 density:0.333333333333333 bootstrap:0.261799215 cc_score:0.0 bp_score:0.34267 mf_score:0.0 relationship: child_of NeXO:9757 ! CC: | BP: actin cortical patch localization | MF: relationship: linked_to NeXO:8567 ! CC: | BP: | MF: [Term] id: NeXO:9476 name: CC: coated pit | BP: | MF: def: "CC_def: A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.28945689415246 density:0.0605042016806723 bootstrap:0.126711906 cc_score:0.165524 bp_score:0.084379 mf_score:0.0 relationship: child_of NeXO:9726 ! CC: | BP: | MF: [Term] id: NeXO:9477 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53778153818743 density:0.0168831168831169 bootstrap:0.207426571 cc_score:0.0 bp_score:0.0451436 mf_score:0.0334057 relationship: child_of NeXO:9802 ! CC: | BP: | MF: [Term] id: NeXO:9474 name: CC: | BP: transcription elongation from RNA polymerase II promoter | MF: def: "CC_def: | BP_def: The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.2099410791707 density:0.924242424242424 bootstrap:0.573312298 cc_score:0.0 bp_score:0.14683 mf_score:0.0 relationship: child_of NeXO:9610 ! CC: RSC complex | BP: nucleosome disassembly | MF:DNA-dependent ATPase activity [Term] id: NeXO:9475 name: CC: F-actin capping protein complex | BP: barbed-end actin filament capping | MF: def: "CC_def: A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. | BP_def: The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.54340624312769 density:1 bootstrap:0.69348979 cc_score:0.584654 bp_score:0.353486 mf_score:0.0 relationship: child_of NeXO:9711 ! CC: actin filament | BP: negative regulation of actin filament polymerization | MF: relationship: linked_to NeXO:8604 ! CC: | BP: | MF: relationship: linked_to NeXO:9356 ! CC: prefoldin complex | BP: tubulin complex assembly | MF: relationship: linked_to NeXO:7717 ! CC: | BP: actin filament-based movement | MF: [Term] id: NeXO:9457 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20013167791103 density:0.0833333333333333 bootstrap:0.155025376 cc_score:0.0 bp_score:0.0555211 mf_score:0.0 relationship: child_of NeXO:9701 ! CC: | BP: | MF: [Term] id: NeXO:8576 name: CC: | BP: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription | MF:3'-5'-exoribonuclease activity def: "CC_def: | BP_def: The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription. | MF_def:Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:3.4598329298096 density:1 bootstrap:0.661162838 cc_score:0.0 bp_score:0.46092 mf_score:0.166962 relationship: child_of NeXO:9449 ! CC: exosome (RNase complex) | BP: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:6228 ! CC: | BP: polyadenylation-dependent snoRNA 3'-end processing | MF: [Term] id: NeXO:6301 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.57063806470234 density:0.333333333333333 bootstrap:0.49949518 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6302 ! CC: | BP: | MF:organic anion transmembrane transporter activity [Term] id: NeXO:8189 name: CC: | BP: mitotic cell cycle spindle assembly checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.7767277480457 density:1 bootstrap:0.7878246 cc_score:0.0 bp_score:0.125894 mf_score:0.0948059 relationship: child_of NeXO:9437 ! CC: | BP: | MF:negative regulation of signal transduction relationship: linked_to NeXO:9285 ! CC: | BP: cell shape checkpoint | MF:protein phosphatase type 2A regulator activity [Term] id: NeXO:5176 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11340848941949 density:0.333333333333333 bootstrap:0.90436961 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6865 ! CC: | BP: | MF: [Term] id: NeXO:6007 name: CC: | BP: antimonite transport | MF:bile acid transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [NeXO-GO:term] namespace: NeXO comment: robustness:1.82043346510776 density:0.166666666666667 bootstrap:0.77989991 cc_score:0.0 bp_score:0.231043 mf_score:0.422682 relationship: child_of NeXO:6434 ! CC: | BP: | MF:monocarboxylic acid transmembrane transporter activity [Term] id: NeXO:6004 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.630294423 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6437 ! CC: | BP: | MF: [Term] id: NeXO:6005 name: CC: | BP: alanyl-tRNA aminoacylation | MF:alanine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.83799181516754 density:0.333333333333333 bootstrap:0.684015922 cc_score:0.0 bp_score:0.220156 mf_score:0.230343 relationship: child_of NeXO:7230 ! CC: | BP: | MF: [Term] id: NeXO:6002 name: CC: | BP: | MF:2-aminoadipate transaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.62895291255329 density:0.5 bootstrap:0.8712854 cc_score:0.0 bp_score:0.0660706 mf_score:0.193535 relationship: child_of NeXO:6214 ! CC: | BP: | MF:anion transmembrane transporter activity [Term] id: NeXO:6003 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.795575503 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6788 ! CC: | BP: | MF: [Term] id: NeXO:6447 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.696795753 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7153 ! CC: | BP: | MF: [Term] id: NeXO:6001 name: CC: | BP: glycerophosphodiester transport | MF:glycerophosphodiester transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. | MF_def:Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8050424 cc_score:0.0 bp_score:0.31677 mf_score:0.324027 relationship: child_of NeXO:6002 ! CC: | BP: | MF:2-aminoadipate transaminase activity [Term] id: NeXO:6008 name: CC: | BP: | MF:membrane insertase activity def: "CC_def: | BP_def: | MF_def:Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.79420259 cc_score:0.0 bp_score:0.0 mf_score:0.230524 relationship: child_of NeXO:6669 ! CC: | BP: | MF: [Term] id: NeXO:6009 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.0114427889782 density:0.333333333333333 bootstrap:0.81920847 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6876 ! CC: | BP: | MF:protein phosphatase 2B binding [Term] id: NeXO:9367 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.51411304327301 density:0.0524390243902439 bootstrap:0.21336126 cc_score:0.0 bp_score:0.0681365 mf_score:0.0 relationship: child_of NeXO:9745 ! CC: | BP: | MF: [Term] id: NeXO:9458 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.15947637622717 density:0.132352941176471 bootstrap:0.298054582 cc_score:0.0781113 bp_score:0.0424418 mf_score:0.0 relationship: child_of NeXO:9744 ! CC: | BP: | MF: [Term] id: NeXO:5760 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.768671311 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6377 ! CC: | BP: regulation of transcription during meiosis | MF: [Term] id: NeXO:7395 name: CC: | BP: | MF:protein complex binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.66562861 cc_score:0.0 bp_score:0.0 mf_score:0.108801 relationship: child_of NeXO:8419 ! CC: | BP: | MF: relationship: linked_to NeXO:9362 ! CC: | BP: | MF: [Term] id: NeXO:7394 name: CC: | BP: | MF:metallochaperone activity def: "CC_def: | BP_def: | MF_def:Assists in the delivery of metal ions to target proteins or compartments." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.246533015 cc_score:0.0 bp_score:0.0 mf_score:0.145851 relationship: child_of NeXO:7794 ! CC: | BP: mitochondrial respiratory chain complex IV assembly | MF: [Term] id: NeXO:7397 name: CC: | BP: | MF:squalene monooxygenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the formation of a 2,3-epoxide in squalene." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.779975263 cc_score:0.0 bp_score:0.0 mf_score:0.446246 relationship: child_of NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity relationship: linked_to NeXO:7961 ! CC: | BP: | MF:diphosphomevalonate decarboxylase activity [Term] id: NeXO:9273 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.59893279984204 density:0.158333333333333 bootstrap:0.326479069 cc_score:0.0 bp_score:0.0143171 mf_score:0.0 relationship: child_of NeXO:9744 ! CC: | BP: | MF: [Term] id: NeXO:9274 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.80371229545442 density:0.0553359683794466 bootstrap:0.237365627 cc_score:0.0 bp_score:0.0296225 mf_score:0.0 relationship: child_of NeXO:9664 ! CC: | BP: | MF: [Term] id: NeXO:7390 name: CC: Rab-protein geranylgeranyltransferase complex | BP: activation of Rab GTPase activity | MF:Rab GDP-dissociation inhibitor activity def: "CC_def: A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. | BP_def: Any process that initiates the activity of an inactive GTPase of the Rab family through the replacement of GDP by GTP. | MF_def:Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77920392 cc_score:0.218799 bp_score:0.44476 mf_score:0.444289 relationship: child_of NeXO:9001 ! CC: | BP: activation of Ras GTPase activity | MF: relationship: linked_to NeXO:8892 ! CC: | BP: membrane addition at site of cytokinesis | MF: [Term] id: NeXO:5148 name: CC: | BP: | MF:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.765592623 cc_score:0.0 bp_score:0.0806436 mf_score:0.201058 relationship: child_of NeXO:5164 ! CC: | BP: pantothenate transmembrane transport | MF:pantothenate transmembrane transporter activity [Term] id: NeXO:5149 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84053224 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5378 ! CC: | BP: | MF: [Term] id: NeXO:5146 name: CC: | BP: aspartate biosynthetic process | MF:2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. | MF_def:Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.376993619 cc_score:0.0 bp_score:0.201369 mf_score:0.314889 relationship: child_of NeXO:5148 ! CC: | BP: | MF:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Term] id: NeXO:9279 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.22854635863446 density:0.0423280423280423 bootstrap:0.148630932 cc_score:0.0 bp_score:0.049684 mf_score:0.0 relationship: child_of NeXO:9675 ! CC: | BP: | MF: [Term] id: NeXO:5144 name: CC: | BP: | MF:acylglycerol lipase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85408104 cc_score:0.0 bp_score:0.0 mf_score:0.27129 relationship: child_of NeXO:5473 ! CC: | BP: | MF:sterol esterase activity [Term] id: NeXO:5145 name: CC: | BP: negative regulation of microtubule depolymerization | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82777273 cc_score:0.0 bp_score:0.152272 mf_score:0.0 relationship: child_of NeXO:5399 ! CC: | BP: negative regulation of microtubule polymerization or depolymerization | MF: [Term] id: NeXO:5142 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.873251948 cc_score:0.0 bp_score:0.0365188 mf_score:0.0 relationship: child_of NeXO:5167 ! CC: | BP: | MF: [Term] id: NeXO:5143 name: CC: | BP: arginine catabolic process | MF:ornithine-oxo-acid transaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. | MF_def:Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8479917 cc_score:0.0 bp_score:0.294718 mf_score:0.43978 relationship: child_of NeXO:5374 ! CC: | BP: | MF:trans-aconitate 3-methyltransferase activity [Term] id: NeXO:5140 name: CC: | BP: homing of group II introns | MF: def: "CC_def: | BP_def: Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.91779738 cc_score:0.0 bp_score:0.447088 mf_score:0.0 relationship: child_of NeXO:5141 ! CC: chloroplast | BP: | MF: [Term] id: NeXO:5141 name: CC: chloroplast | BP: | MF: def: "CC_def: A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.16462694435559 density:0.666666666666667 bootstrap:0.912678842 cc_score:0.588672 bp_score:0.0472177 mf_score:0.0992846 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:5089 name: CC: | BP: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway | MF:pyruvate decarboxylase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. | MF_def:Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:2.42719779170058 density:1 bootstrap:0.97618512 cc_score:0.0 bp_score:0.445666 mf_score:0.441599 relationship: child_of NeXO:5494 ! CC: | BP: L-phenylalanine catabolic process | MF: [Term] id: NeXO:5112 name: CC: | BP: arginyl-tRNA aminoacylation | MF:arginine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.19150428276811 density:0.0222222222222222 bootstrap:0.62250851 cc_score:0.0 bp_score:0.105401 mf_score:0.115296 relationship: child_of NeXO:5169 ! CC: | BP: glutaminyl-tRNA aminoacylation | MF:glutamine-tRNA ligase activity [Term] id: NeXO:8652 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.418073932 cc_score:0.0 bp_score:0.0271873 mf_score:0.0 relationship: child_of NeXO:9529 ! CC: | BP: cAMP biosynthetic process | MF: [Term] id: NeXO:5930 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.786285688 cc_score:0.0 bp_score:0.0214345 mf_score:0.0 relationship: child_of NeXO:6966 ! CC: | BP: | MF: [Term] id: NeXO:5429 name: CC: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | BP: trehalose biosynthetic process | MF:trehalose-phosphatase activity def: "CC_def: A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present. | BP_def: The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. | MF_def:Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.02263750450728 density:1 bootstrap:0.89375807 cc_score:0.656341 bp_score:0.378685 mf_score:0.890865 relationship: child_of NeXO:7350 ! CC: | BP: trehalose metabolic process | MF:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [Term] id: NeXO:5761 name: CC: | BP: D-amino acid catabolic process | MF:D-tyrosyl-tRNA(Tyr) deacylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. | MF_def:Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:2.20629950514487 density:1 bootstrap:0.80658619 cc_score:0.0 bp_score:0.441522 mf_score:0.438845 relationship: child_of NeXO:7560 ! CC: | BP: | MF: [Term] id: NeXO:5428 name: CC: | BP: guanosine catabolic process | MF:purine-nucleoside phosphorylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution. | MF_def:Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64541789 cc_score:0.0 bp_score:0.27396 mf_score:0.270506 relationship: child_of NeXO:5736 ! CC: | BP: ribonucleoside catabolic process | MF:nicotinamide riboside hydrolase activity [Term] id: NeXO:8985 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.12237563435568 density:0.065359477124183 bootstrap:0.174842628 cc_score:0.0 bp_score:0.0387774 mf_score:0.0505003 relationship: child_of NeXO:9620 ! CC: | BP: | MF: [Term] id: NeXO:6445 name: CC: | BP: | MF:tRNA (uracil) methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.5631197 cc_score:0.0 bp_score:0.0 mf_score:0.217795 relationship: child_of NeXO:6505 ! CC: eRF1 methyltransferase complex | BP: peptidyl-glutamine methylation | MF: [Term] id: NeXO:7956 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10284938379184 density:0.0808823529411765 bootstrap:0.31525307 cc_score:0.0 bp_score:0.0382925 mf_score:0.0454698 relationship: child_of NeXO:9085 ! CC: | BP: | MF: [Term] id: NeXO:5886 name: CC: | BP: cellular potassium ion homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95228368689982 density:1 bootstrap:0.631549939 cc_score:0.0 bp_score:0.293786 mf_score:0.0 relationship: child_of NeXO:6837 ! CC: | BP: potassium ion transmembrane transport | MF:potassium ion transmembrane transporter activity [Term] id: NeXO:5681 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72381976 cc_score:0.0 bp_score:0.0107144 mf_score:0.0 relationship: child_of NeXO:5985 ! CC: | BP: | MF: [Term] id: NeXO:7955 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.380383446 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8567 ! CC: | BP: | MF: relationship: linked_to NeXO:9024 ! CC: | BP: actin cytoskeleton reorganization | MF: [Term] id: NeXO:5132 name: CC: plasma membrane succinate dehydrogenase complex | BP: diadenosine polyphosphate catabolic process | MF:bis(5'-adenosyl)-pentaphosphatase activity def: "CC_def: A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species. | BP_def: The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. | MF_def:Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81907569 cc_score:0.441029 bp_score:0.446516 mf_score:0.443352 relationship: child_of NeXO:6391 ! CC: | BP: purine ribonucleoside catabolic process | MF:bis(5'-adenosyl)-hexaphosphatase activity [Term] id: NeXO:5680 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.852772962 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6989 ! CC: | BP: | MF:sequence-specific DNA binding transcription factor recruiting transcription factor activity [Term] id: NeXO:6312 name: CC: | BP: Golgi localization | MF: def: "CC_def: | BP_def: Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.815626611 cc_score:0.0 bp_score:0.292304 mf_score:0.0 relationship: child_of NeXO:6826 ! CC: | BP: Golgi organization | MF: [Term] id: NeXO:6313 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.682556411 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6453 ! CC: | BP: | MF: relationship: linked_to NeXO:8835 ! CC: | BP: regulation of G-protein coupled receptor protein signaling pathway | MF:peptide-methionine (R)-S-oxide reductase activity relationship: linked_to NeXO:8546 ! CC: | BP: negative regulation of glycogen catabolic process | MF: [Term] id: NeXO:6310 name: CC: | BP: positive regulation of mating type switching | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of mating type switching. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8307601 cc_score:0.0 bp_score:0.438649 mf_score:0.0 relationship: child_of NeXO:7522 ! CC: | BP: regulation of mating type switching | MF: [Term] id: NeXO:7954 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.10018509466728 density:0.0857142857142857 bootstrap:0.37264437 cc_score:0.0 bp_score:0.0701259 mf_score:0.0 relationship: child_of NeXO:9049 ! CC: | BP: | MF: [Term] id: NeXO:6316 name: CC: | BP: regulation of transcription from RNA polymerase II promoter in response to iron | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30881638529001 density:0.2 bootstrap:0.6440949 cc_score:0.0 bp_score:0.28994 mf_score:0.0 relationship: child_of NeXO:6909 ! CC: | BP: cellular response to metal ion | MF: [Term] id: NeXO:6317 name: CC: | BP: | MF:methionine-R-sulfoxide reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.98764816 cc_score:0.0 bp_score:0.0 mf_score:0.445136 relationship: child_of NeXO:8100 ! CC: | BP: | MF:L-methionine-(R)-S-oxide reductase activity [Term] id: NeXO:6314 name: CC: | BP: | MF:Rab GTPase binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [NeXO-GO:term] namespace: NeXO comment: robustness:2.3595005345218 density:1 bootstrap:0.922490722 cc_score:0.0 bp_score:0.0 mf_score:0.355657 relationship: child_of NeXO:8279 ! CC: | BP: | MF: relationship: linked_to NeXO:6826 ! CC: | BP: Golgi organization | MF: [Term] id: NeXO:6315 name: CC: | BP: negative regulation of transcription from RNA polymerase II promoter in response to iron | MF: def: "CC_def: | BP_def: Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.57203375659112 density:1 bootstrap:0.409492151 cc_score:0.0 bp_score:0.888373 mf_score:0.0 relationship: child_of NeXO:6316 ! CC: | BP: regulation of transcription from RNA polymerase II promoter in response to iron | MF: [Term] id: NeXO:7225 name: CC: | BP: NADH regeneration | MF:malate dehydrogenase activity def: "CC_def: | BP_def: A metabolic process that generates a pool of NADH by the reduction of NAD+. | MF_def:Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.94050385690013 density:0.5 bootstrap:0.572059599 cc_score:0.0 bp_score:0.161478 mf_score:0.259652 relationship: child_of NeXO:7806 ! CC: | BP: negative regulation of nucleotide metabolic process | MF: [Term] id: NeXO:6993 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.57141545599249 density:0.109090909090909 bootstrap:0.345669149 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7803 ! CC: | BP: | MF: [Term] id: NeXO:9788 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.4116759412411 density:0.933333333333333 bootstrap:0.358077575 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9891 ! CC: | BP: | MF: [Term] id: NeXO:8980 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.2133146173045 density:0.196969696969697 bootstrap:0.567088299 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9174 ! CC: | BP: | MF: [Term] id: NeXO:6442 name: CC: | BP: dITP catabolic process | MF:dITP diphosphatase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position. | MF_def:Catalysis of the reaction: dITP + H2O = dIMP + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.30781068698319 density:0.5 bootstrap:0.72390081 cc_score:0.0 bp_score:0.251636 mf_score:0.254288 relationship: child_of NeXO:7231 ! CC: | BP: dUTP catabolic process | MF:dUTP diphosphatase activity [Term] id: NeXO:5426 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.08411130557206 density:0.666666666666667 bootstrap:0.86682819 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6677 ! CC: | BP: | MF: [Term] id: NeXO:9099 name: CC: | BP: cellular response to ethanol | MF:TFIIB-class transcription factor binding def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. | MF_def:Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.311301035 cc_score:0.0 bp_score:0.164008 mf_score:0.273017 relationship: child_of NeXO:9626 ! CC: | BP: positive regulation of transcription initiation from RNA polymerase II promoter | MF:TFIID-class binding transcription factor activity relationship: linked_to NeXO:9672 ! CC: | BP: | MF: [Term] id: NeXO:9094 name: CC: nuclear telomeric heterochromatin | BP: loss of chromatin silencing involved in replicative cell aging | MF:structural constituent of chromatin def: "CC_def: Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus. | BP_def: | MF_def:The action of a molecule that contributes to the structural integrity of chromatin." [NeXO-GO:term] namespace: NeXO comment: robustness:3.81232930388811 density:1 bootstrap:0.80274756 cc_score:0.440487 bp_score:0.382426 mf_score:0.583647 relationship: child_of NeXO:9700 ! CC: pre-replicative complex | BP: progressive alteration of chromatin involved in replicative cell aging | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:7636 ! CC: | BP: negative regulation of transcription by competitive promoter binding | MF: relationship: linked_to NeXO:9200 ! CC: | BP: | MF: [Term] id: NeXO:9095 name: CC: | BP: regulation of transcription from RNA polymerase II promoter by pheromones | MF: def: "CC_def: | BP_def: Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.39078088232721 density:0.3 bootstrap:0.428787721 cc_score:0.0 bp_score:0.100944 mf_score:0.0 relationship: child_of NeXO:9569 ! CC: | BP: termination of RNA polymerase I transcription | MF: [Term] id: NeXO:9096 name: CC: MutSalpha complex | BP: response to UV | MF:single base insertion or deletion binding def: "CC_def: A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. | MF_def:Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [NeXO-GO:term] namespace: NeXO comment: robustness:1.76365023108501 density:1 bootstrap:0.515402791 cc_score:0.221606 bp_score:0.175946 mf_score:0.298774 relationship: child_of NeXO:9602 ! CC: | BP: mitotic cell cycle G1/S transition DNA damage checkpoint | MF: relationship: linked_to NeXO:9128 ! CC: PCNA complex | BP: | MF:DNA polymerase processivity factor activity relationship: linked_to NeXO:7238 ! CC: | BP: strand invasion | MF: relationship: linked_to NeXO:7383 ! CC: DNA replication factor A complex | BP: | MF: relationship: linked_to NeXO:8266 ! CC: MutLbeta complex | BP: chiasma assembly | MF:DNA insertion or deletion binding relationship: linked_to NeXO:9009 ! CC: | BP: heteroduplex formation | MF:recombinase activity [Term] id: NeXO:9097 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.7118304043326 density:0.8 bootstrap:0.73349842 cc_score:0.0 bp_score:0.0161313 mf_score:0.0 relationship: child_of NeXO:9613 ! CC: | BP: | MF: [Term] id: NeXO:9091 name: CC: Nic96 complex | BP: ribosomal small subunit export from nucleus | MF: def: "CC_def: A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p. | BP_def: The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.90735211871453 density:0.666666666666667 bootstrap:0.394321869 cc_score:0.485634 bp_score:0.157713 mf_score:0.0 relationship: child_of NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: relationship: linked_to NeXO:9774 ! CC: | BP: regulation of protein desumoylation | MF: relationship: linked_to NeXO:9093 ! CC: | BP: | MF: [Term] id: NeXO:9092 name: CC: NDC1 complex | BP: mRNA export from nucleus in response to heat stress | MF: def: "CC_def: A protein complex that forms part of the nuclear pore complex, and contains three transmembrane nucleoporins, encoded in S. cerevisiae by Ndc1p, Pom152p and Pom34p. | BP_def: The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.14266485403359 density:1 bootstrap:0.62520815 cc_score:0.293713 bp_score:0.205694 mf_score:0.0 relationship: child_of NeXO:9461 ! CC: | BP: | MF: relationship: linked_to NeXO:9415 ! CC: | BP: ribosomal large subunit export from nucleus | MF: [Term] id: NeXO:9093 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17793173208292 density:0.142857142857143 bootstrap:0.433403386 cc_score:0.0 bp_score:0.0227852 mf_score:0.0 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport [Term] id: NeXO:9652 name: CC: SCF ubiquitin ligase complex | BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: def: "CC_def: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.22737537445641 density:0.320512820512821 bootstrap:0.500236822 cc_score:0.352808 bp_score:0.313229 mf_score:0.0918998 relationship: child_of NeXO:9761 ! CC: cullin-RING ubiquitin ligase complex | BP: | MF: [Term] id: NeXO:9653 name: CC: | BP: purine nucleoside monophosphate biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.97830925325733 density:0.0789779326364692 bootstrap:0.139665717 cc_score:0.0 bp_score:0.115967 mf_score:0.0 relationship: child_of NeXO:9813 ! CC: | BP: | MF: [Term] id: NeXO:9650 name: CC: retromer complex, inner shell | BP: retrograde transport, endosome to Golgi | MF: def: "CC_def: One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p. | BP_def: The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.44851876737186 density:1 bootstrap:0.70437816 cc_score:0.379257 bp_score:0.117039 mf_score:0.0 relationship: child_of NeXO:9838 ! CC: | BP: | MF: relationship: linked_to NeXO:9512 ! CC: | BP: vacuole inheritance | MF: [Term] id: NeXO:9651 name: CC: | BP: detoxification of arsenic-containing substance | MF: def: "CC_def: | BP_def: Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.53107555502291 density:1 bootstrap:0.56697926 cc_score:0.0 bp_score:0.220735 mf_score:0.0 relationship: child_of NeXO:9695 ! CC: | BP: protein insertion into membrane | MF: relationship: linked_to NeXO:6984 ! CC: early endosome | BP: early endosome to Golgi transport | MF: relationship: linked_to NeXO:8807 ! CC: | BP: | MF: relationship: linked_to NeXO:9496 ! CC: integral to endosome membrane | BP: Golgi to plasma membrane protein transport | MF: [Term] id: NeXO:9656 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.58360809647111 density:0.0650793650793651 bootstrap:0.12851436 cc_score:0.0401595 bp_score:0.0487847 mf_score:0.0 relationship: child_of NeXO:9867 ! CC: | BP: mitotic spindle organization | MF: [Term] id: NeXO:9309 name: CC: proteasome core complex, beta-subunit complex | BP: endopeptidase activity | MF: def: "CC_def: The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. | BP_def: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.58424698313418 density:0.6 bootstrap:0.546544176 cc_score:0.343109 bp_score:0.231152 mf_score:0.0 relationship: child_of NeXO:9608 ! CC: proteasome core complex | BP: proteasomal ubiquitin-independent protein catabolic process | MF:threonine-type endopeptidase activity [Term] id: NeXO:8531 name: CC: | BP: DNA geometric change | MF: def: "CC_def: | BP_def: The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.77876823818831 density:0.666666666666667 bootstrap:0.2883445 cc_score:0.0 bp_score:0.11049 mf_score:0.0 relationship: child_of NeXO:8555 ! CC: | BP: | MF: relationship: linked_to NeXO:9428 ! CC: | BP: DNA replication checkpoint | MF: relationship: linked_to NeXO:7771 ! CC: | BP: | MF: [Term] id: NeXO:5073 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71382131 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5075 ! CC: | BP: | MF:protein N-terminal asparagine amidohydrolase activity [Term] id: NeXO:9304 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.65815996019057 density:1 bootstrap:0.390265718 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9584 ! CC: | BP: | MF: relationship: linked_to NeXO:7228 ! CC: | BP: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process | MF: relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: [Term] id: NeXO:9789 name: CC: | BP: regulation of exit from mitosis | MF:histone serine kinase activity def: "CC_def: | BP_def: Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. | MF_def:Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [NeXO-GO:term] namespace: NeXO comment: robustness:4.83254804125884 density:0.666666666666667 bootstrap:0.320591453 cc_score:0.0 bp_score:0.116093 mf_score:0.116761 relationship: child_of NeXO:9896 ! CC: | BP: pheromone-dependent signal transduction involved in conjugation with cellular fusion | MF:receptor signaling protein activity [Term] id: NeXO:9658 name: CC: | BP: regulation of ceramide biosynthetic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of ceramide biosynthetic process. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.76751609177075 density:1 bootstrap:0.476039231 cc_score:0.080011 bp_score:0.172185 mf_score:0.0 relationship: child_of NeXO:9754 ! CC: | BP: | MF: relationship: linked_to NeXO:9694 ! CC: | BP: | MF: relationship: linked_to NeXO:9695 ! CC: | BP: protein insertion into membrane | MF: [Term] id: NeXO:9307 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32436213527749 density:0.108333333333333 bootstrap:0.278483276 cc_score:0.0 bp_score:0.0439402 mf_score:0.0399844 relationship: child_of NeXO:9698 ! CC: | BP: leading strand elongation | MF: [Term] id: NeXO:9300 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.85587484668987 density:0.0243257535695399 bootstrap:0.21735803 cc_score:0.0 bp_score:0.0233945 mf_score:0.013635 relationship: child_of NeXO:9766 ! CC: | BP: | MF: [Term] id: NeXO:5070 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.838932513 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5410 ! CC: | BP: | MF: [Term] id: NeXO:6443 name: CC: | BP: protein lipoylation | MF:lipoate-protein ligase activity def: "CC_def: | BP_def: The addition of a lipoyl group to an amino acid residue in a protein. | MF_def:Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:5.0512189404427 density:1 bootstrap:0.70462322 cc_score:0.0 bp_score:0.537811 mf_score:0.428148 relationship: child_of NeXO:7734 ! CC: | BP: fatty acid biosynthetic process | MF:lipoate biosynthetic process [Term] id: NeXO:9303 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.69083696077232 density:0.0759183673469388 bootstrap:0.188033455 cc_score:0.0 bp_score:0.064875 mf_score:0.0452051 relationship: child_of NeXO:9720 ! CC: | BP: | MF: [Term] id: NeXO:5098 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87965146 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6784 ! CC: | BP: | MF: [Term] id: NeXO:5099 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.877458912 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6777 ! CC: | BP: | MF: [Term] id: NeXO:7245 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.727931559 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8186 ! CC: | BP: | MF:cyclic-nucleotide phosphodiesterase activity [Term] id: NeXO:7244 name: CC: | BP: DNA unwinding involved in replication | MF:four-way junction helicase activity def: "CC_def: | BP_def: The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. | MF_def:Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.96031306 cc_score:0.0 bp_score:0.198839 mf_score:0.440524 relationship: child_of NeXO:7839 ! CC: | BP: DNA duplex unwinding | MF:single-stranded DNA-dependent ATPase activity relationship: linked_to NeXO:8531 ! CC: | BP: DNA geometric change | MF: [Term] id: NeXO:7243 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19309942373454 density:1 bootstrap:0.796963604 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7717 ! CC: | BP: actin filament-based movement | MF: [Term] id: NeXO:7241 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82877631 cc_score:0.0 bp_score:0.0285462 mf_score:0.0 relationship: child_of NeXO:7976 ! CC: | BP: | MF: [Term] id: NeXO:7240 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.81624984766068 density:0.7 bootstrap:0.61915172 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7931 ! CC: | BP: | MF: relationship: linked_to NeXO:9197 ! CC: | BP: | MF: [Term] id: NeXO:5090 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.7033649 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5113 ! CC: | BP: | MF: [Term] id: NeXO:5076 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.9158158 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6831 ! CC: | BP: | MF: [Term] id: NeXO:5092 name: CC: phenylalanine-tRNA ligase complex | BP: phenylalanyl-tRNA aminoacylation | MF:phenylalanine-tRNA ligase activity def: "CC_def: An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). | BP_def: The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.36021242540526 density:1 bootstrap:0.92304746 cc_score:0.875115 bp_score:0.566017 mf_score:0.586554 relationship: child_of NeXO:5093 ! CC: | BP: | MF: [Term] id: NeXO:5093 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.31573454537094 density:0.0357142857142857 bootstrap:0.63297129 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5096 ! CC: | BP: | MF: [Term] id: NeXO:5094 name: CC: | BP: cysteine biosynthetic process from serine | MF:cysteine synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. | MF_def:Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.94766509 cc_score:0.0 bp_score:0.294377 mf_score:0.293917 relationship: child_of NeXO:5806 ! CC: | BP: | MF: [Term] id: NeXO:5095 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.66242718 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5103 ! CC: | BP: | MF: [Term] id: NeXO:7249 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64357659 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7333 ! CC: | BP: | MF: [Term] id: NeXO:5097 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73674495 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5108 ! CC: | BP: | MF: [Term] id: NeXO:9780 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.4078325865555 density:0.984848484848485 bootstrap:0.61160954 cc_score:0.0 bp_score:0.0679544 mf_score:0.0 relationship: child_of NeXO:9949 ! CC: | BP: | MF: relationship: linked_to NeXO:9779 ! CC: | BP: | MF: relationship: linked_to NeXO:9752 ! CC: | BP: | MF: relationship: linked_to NeXO:9606 ! CC: | BP: | MF: [Term] id: NeXO:9781 name: CC: mitochondrial matrix | BP: oxidative phosphorylation | MF:monovalent inorganic cation transmembrane transporter activity def: "CC_def: The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. | BP_def: The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. | MF_def:Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:15.6119201765335 density:0.105159705159705 bootstrap:0.332394416 cc_score:0.128391 bp_score:0.165449 mf_score:0.138143 relationship: child_of NeXO:9798 ! CC: mitochondrial inner membrane | BP: | MF: [Term] id: NeXO:9782 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.06761093716375 density:0.137254901960784 bootstrap:0.137933144 cc_score:0.0730912 bp_score:0.0676109 mf_score:0.0 relationship: child_of NeXO:9910 ! CC: | BP: | MF: [Term] id: NeXO:9783 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.89195465762556 density:0.0179824561403509 bootstrap:0.085429575 cc_score:0.0 bp_score:0.0443019 mf_score:0.0252183 relationship: child_of NeXO:9895 ! CC: | BP: | MF: [Term] id: NeXO:8532 name: CC: | BP: regulation of DNA-dependent DNA replication initiation | MF:protein kinase activator activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. | MF_def:Increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.11272808247001 density:0.0666666666666667 bootstrap:0.37029948 cc_score:0.0 bp_score:0.101982 mf_score:0.106167 relationship: child_of NeXO:9576 ! CC: DNA replication preinitiation complex | BP: double-strand break repair via break-induced replication | MF: [Term] id: NeXO:7959 name: CC: | BP: | MF:sterol 14-demethylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:4.04885401046765 density:0.666666666666667 bootstrap:0.764750609 cc_score:0.0 bp_score:0.0 mf_score:0.20978 relationship: child_of NeXO:8901 ! CC: | BP: ergosterol biosynthetic process | MF:monooxygenase activity relationship: linked_to NeXO:7493 ! CC: | BP: | MF:C-8 sterol isomerase activity relationship: linked_to NeXO:7098 ! CC: | BP: | MF:delta14-sterol reductase activity [Term] id: NeXO:9787 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:16.1029409579391 density:0.847619047619048 bootstrap:0.524168278 cc_score:0.0 bp_score:0.0627891 mf_score:0.0 relationship: child_of NeXO:9851 ! CC: | BP: | MF: relationship: linked_to NeXO:9879 ! CC: | BP: | MF: [Term] id: NeXO:8963 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.68787006261222 density:0.0277777777777778 bootstrap:0.189788541 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9528 ! CC: rough endoplasmic reticulum membrane | BP: protein targeting to ER | MF: [Term] id: NeXO:8962 name: CC: | BP: CAAX-box protein processing | MF: def: "CC_def: | BP_def: The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94688330200527 density:1 bootstrap:0.628060799 cc_score:0.0 bp_score:0.293283 mf_score:0.0 relationship: child_of NeXO:9349 ! CC: | BP: | MF: relationship: linked_to NeXO:7221 ! CC: | BP: | MF: relationship: linked_to NeXO:7949 ! CC: | BP: | MF: relationship: linked_to NeXO:9170 ! CC: | BP: | MF: [Term] id: NeXO:7958 name: CC: | BP: negative regulation of peptidase activity | MF:tRNA-specific adenosine-37 deaminase activity def: "CC_def: | BP_def: Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. | MF_def:Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64553269 cc_score:0.0 bp_score:0.177113 mf_score:0.448693 relationship: child_of NeXO:8644 ! CC: | BP: | MF:cysteine-type endopeptidase inhibitor activity [Term] id: NeXO:6440 name: CC: | BP: | MF:mating-type a-factor pheromone receptor activity def: "CC_def: | BP_def: | MF_def:Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [NeXO-GO:term] namespace: NeXO comment: robustness:3.20399235572005 density:0.5 bootstrap:0.67917347 cc_score:0.0 bp_score:0.0 mf_score:0.238194 relationship: child_of NeXO:6600 ! CC: | BP: | MF: [Term] id: NeXO:8966 name: CC: | BP: agglutination involved in conjugation with cellular fusion | MF: def: "CC_def: | BP_def: During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.65189418752543 density:1 bootstrap:0.73660481 cc_score:0.0 bp_score:0.146922 mf_score:0.0 relationship: child_of NeXO:9822 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:9365 ! CC: | BP: galactose catabolic process | MF: [Term] id: NeXO:8964 name: CC: | BP: | MF:translation elongation factor activity def: "CC_def: | BP_def: | MF_def:Functions in chain elongation during polypeptide synthesis at the ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:3.32541519909032 density:0.5 bootstrap:0.448507866 cc_score:0.0 bp_score:0.0 mf_score:0.135458 relationship: child_of NeXO:9374 ! CC: | BP: | MF: [Term] id: NeXO:6820 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09065495994724 density:1 bootstrap:0.72424678 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7805 ! CC: | BP: | MF: relationship: linked_to NeXO:9133 ! CC: | BP: positive regulation of sequence-specific DNA binding transcription factor activity | MF: [Term] id: NeXO:6821 name: CC: | BP: positive regulation of mitotic cell cycle | MF:dihydrolipoyl dehydrogenase activity def: "CC_def: | BP_def: Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. | MF_def:Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.39113723070316 density:1 bootstrap:0.94739448 cc_score:0.0 bp_score:0.294909 mf_score:0.295709 relationship: child_of NeXO:7941 ! CC: | BP: attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation | MF: [Term] id: NeXO:6822 name: CC: cell projection membrane | BP: | MF: def: "CC_def: The portion of the plasma membrane surrounding a cell surface projection. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.10996334897073 density:1 bootstrap:0.737686218 cc_score:0.201893 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7683 ! CC: | BP: | MF: [Term] id: NeXO:6823 name: CC: | BP: protein prenylation | MF:protein prenyltransferase activity def: "CC_def: | BP_def: The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added. | MF_def:Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.71100978002632 density:0.190476190476190 bootstrap:0.474907673 cc_score:0.0 bp_score:0.236931 mf_score:0.241281 relationship: child_of NeXO:7445 ! CC: | BP: | MF: [Term] id: NeXO:6824 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52272765963663 density:0.0714285714285714 bootstrap:0.375402034 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8006 ! CC: | BP: | MF: [Term] id: NeXO:6825 name: CC: | BP: response to amino acid stimulus | MF:dipeptide transporter activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. | MF_def:Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells." [NeXO-GO:term] namespace: NeXO comment: robustness:3.01811696609037 density:0.666666666666667 bootstrap:0.83012802 cc_score:0.0 bp_score:0.427524 mf_score:0.204826 relationship: child_of NeXO:7790 ! CC: | BP: aromatic amino acid transport | MF:aromatic amino acid transmembrane transporter activity [Term] id: NeXO:6826 name: CC: | BP: Golgi organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.672854581 cc_score:0.0 bp_score:0.291114 mf_score:0.0 relationship: child_of NeXO:7618 ! CC: | BP: | MF: relationship: linked_to NeXO:9001 ! CC: | BP: activation of Ras GTPase activity | MF: [Term] id: NeXO:6827 name: CC: | BP: negative regulation of proteolysis | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.339795131 cc_score:0.0 bp_score:0.165759 mf_score:0.0 relationship: child_of NeXO:7415 ! CC: | BP: negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | MF:centromere-specific nucleosome binding [Term] id: NeXO:6828 name: CC: | BP: UTP biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.676175972 cc_score:0.0 bp_score:0.271405 mf_score:0.0500983 relationship: child_of NeXO:8045 ! CC: | BP: | MF: [Term] id: NeXO:9819 name: CC: | BP: regulation of spindle pole body separation | MF:cyclin-dependent protein kinase regulator activity def: "CC_def: | BP_def: Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. | MF_def:Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [NeXO-GO:term] namespace: NeXO comment: robustness:7.076989112135 density:0.5 bootstrap:0.321407371 cc_score:0.0 bp_score:0.319823 mf_score:0.176636 relationship: child_of NeXO:9873 ! CC: | BP: spindle pole body separation | MF:cyclin-dependent protein kinase activity [Term] id: NeXO:5326 name: CC: | BP: | MF:1-pyrroline-5-carboxylate dehydrogenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84715025 cc_score:0.0 bp_score:0.0 mf_score:0.441116 relationship: child_of NeXO:6405 ! CC: | BP: proline catabolic process to glutamate | MF:proline dehydrogenase activity [Term] id: NeXO:5327 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87852876 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6016 ! CC: | BP: | MF: [Term] id: NeXO:5324 name: CC: | BP: tRNA 5'-leader removal | MF: def: "CC_def: | BP_def: Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7638482514263 density:1 bootstrap:0.515518535 cc_score:0.0 bp_score:0.221041 mf_score:0.0 relationship: child_of NeXO:5792 ! CC: | BP: | MF: [Term] id: NeXO:5325 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88548009 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8545 ! CC: | BP: | MF:sterol-transporting ATPase activity [Term] id: NeXO:5322 name: CC: | BP: | MF:kynureninase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83242689 cc_score:0.0 bp_score:0.0708769 mf_score:0.437548 relationship: child_of NeXO:5426 ! CC: | BP: | MF: [Term] id: NeXO:5323 name: CC: | BP: photoreactive repair | MF:deoxyribodipyrimidine photo-lyase activity def: "CC_def: | BP_def: The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. | MF_def:Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.871957359 cc_score:0.0 bp_score:0.437693 mf_score:0.439278 relationship: child_of NeXO:6373 ! CC: | BP: protein-chromophore linkage | MF: [Term] id: NeXO:5320 name: CC: tRNA methyltransferase complex | BP: | MF:tRNA (guanine-N7-)-methyltransferase activity def: "CC_def: A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [NeXO-GO:term] namespace: NeXO comment: robustness:2.18336242408756 density:1 bootstrap:0.78990254 cc_score:0.316193 bp_score:0.0930996 mf_score:0.886318 relationship: child_of NeXO:5493 ! CC: | BP: | MF:tRNA (guanine) methyltransferase activity [Term] id: NeXO:5321 name: CC: | BP: tryptophan catabolic process | MF:arylformamidase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. | MF_def:Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8549262 cc_score:0.0 bp_score:0.110403 mf_score:0.439033 relationship: child_of NeXO:6001 ! CC: | BP: glycerophosphodiester transport | MF:glycerophosphodiester transmembrane transporter activity [Term] id: NeXO:6441 name: CC: ESCRT II complex | BP: negative regulation of transcription from RNA polymerase II promoter by glucose | MF: def: "CC_def: An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. | BP_def: Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.86531173906984 density:1 bootstrap:0.95005066 cc_score:0.351233 bp_score:0.177445 mf_score:0.0 relationship: child_of NeXO:8239 ! CC: ESCRT I complex | BP: regulation of transcription from RNA polymerase II promoter by glucose | MF: relationship: linked_to NeXO:7782 ! CC: | BP: protein processing | MF:calcium-dependent cysteine-type endopeptidase activity [Term] id: NeXO:5328 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8842939 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6421 ! CC: | BP: | MF: [Term] id: NeXO:5329 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85064382 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6606 ! CC: | BP: telomere capping | MF: [Term] id: NeXO:9456 name: CC: | BP: regulation of cytokinesis | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.95658501057389 density:0.8 bootstrap:0.351956976 cc_score:0.0 bp_score:0.272432 mf_score:0.0 relationship: child_of NeXO:9614 ! CC: septin complex | BP: septin ring assembly | MF: [Term] id: NeXO:8236 name: CC: | BP: histone ubiquitination | MF: def: "CC_def: | BP_def: The modification of histones by addition of ubiquitin groups. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.82664873813225 density:1 bootstrap:0.64336281 cc_score:0.0 bp_score:0.16223 mf_score:0.0 relationship: child_of NeXO:9209 ! CC: Set1C/COMPASS complex | BP: histone H3-K4 methylation | MF:histone methyltransferase activity (H3-K4 specific) relationship: linked_to NeXO:9368 ! CC: Cdc73/Paf1 complex | BP: GO:2001173 | MF:TFIIF-class binding transcription factor activity [Term] id: NeXO:8817 name: CC: | BP: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoserine binding def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. | MF_def:Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24643526899272 density:1 bootstrap:0.83619904 cc_score:0.0 bp_score:0.598149 mf_score:0.888203 relationship: child_of NeXO:9792 ! CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding relationship: linked_to NeXO:7732 ! CC: | BP: mitochondria-nucleus signaling pathway | MF: relationship: linked_to NeXO:8931 ! CC: | BP: | MF: relationship: linked_to NeXO:7142 ! CC: | BP: | MF:[acyl-carrier-protein] S-acetyltransferase activity [Term] id: NeXO:8816 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.05089011426002 density:0.0948616600790514 bootstrap:0.135911129 cc_score:0.0 bp_score:0.0537812 mf_score:0.0267722 relationship: child_of NeXO:9562 ! CC: | BP: | MF: [Term] id: NeXO:8815 name: CC: DNA-dependent protein kinase-DNA ligase 4 complex | BP: negative regulation of telomerase activity | MF:telomerase activity def: "CC_def: A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. | BP_def: Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). | MF_def:Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [NeXO-GO:term] namespace: NeXO comment: robustness:2.0094326020548 density:0.666666666666667 bootstrap:0.367976283 cc_score:0.513372 bp_score:0.316992 mf_score:0.112818 relationship: child_of NeXO:9200 ! CC: | BP: | MF: relationship: linked_to NeXO:5479 ! CC: | BP: telomere maintenance via telomerase | MF:ATP-dependent DNA/RNA helicase activity [Term] id: NeXO:8814 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.61433327615727 density:1 bootstrap:0.483265559 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9179 ! CC: | BP: | MF: [Term] id: NeXO:8813 name: CC: Prp19 complex | BP: | MF:first spliceosomal transesterification activity def: "CC_def: A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. | BP_def: | MF_def:Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [NeXO-GO:term] namespace: NeXO comment: robustness:10.2493052281461 density:1 bootstrap:0.82883346 cc_score:0.482604 bp_score:0.0 mf_score:0.415072 relationship: child_of NeXO:9596 ! CC: U2-type catalytic step 1 spliceosome | BP: spliceosomal conformational changes to generate catalytic conformation | MF:RNA splicing, via transesterification reactions [Term] id: NeXO:8812 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.52044456623399 density:0.106719367588933 bootstrap:0.255196784 cc_score:0.0 bp_score:0.0482743 mf_score:0.0328741 relationship: child_of NeXO:9578 ! CC: | BP: | MF: [Term] id: NeXO:8811 name: CC: | BP: | MF:two-component response regulator activity def: "CC_def: | BP_def: | MF_def:Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.31764782 cc_score:0.0 bp_score:0.0 mf_score:0.177821 relationship: child_of NeXO:9272 ! CC: | BP: | MF: relationship: linked_to NeXO:5794 ! CC: | BP: nicotinic acid riboside biosynthetic process | MF: [Term] id: NeXO:8819 name: CC: | BP: Golgi to endosome transport | MF: def: "CC_def: | BP_def: The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82760782313427 density:0.833333333333333 bootstrap:0.516126648 cc_score:0.0389741 bp_score:0.162613 mf_score:0.0 relationship: child_of NeXO:9129 ! CC: clathrin coat | BP: | MF: [Term] id: NeXO:8818 name: CC: | BP: regulation of gluconeogenesis | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.442741682407 density:0.103448275862069 bootstrap:0.242711821 cc_score:0.0 bp_score:0.176937 mf_score:0.0287177 relationship: child_of NeXO:9544 ! CC: | BP: | MF: [Term] id: NeXO:8219 name: CC: | BP: negative regulation of transcription from RNA polymerase I promoter | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.71927465823427 density:1 bootstrap:0.74809332 cc_score:0.0 bp_score:0.331807 mf_score:0.0 relationship: child_of NeXO:8920 ! CC: | BP: negative regulation of chromatin silencing at silent mating-type cassette | MF: [Term] id: NeXO:8218 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.18391896162016 density:0.1 bootstrap:0.374457451 cc_score:0.0 bp_score:0.0618313 mf_score:0.0 relationship: child_of NeXO:8963 ! CC: | BP: | MF: [Term] id: NeXO:6494 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76528309 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7581 ! CC: | BP: | MF: relationship: linked_to NeXO:9024 ! CC: | BP: actin cytoskeleton reorganization | MF: [Term] id: NeXO:8211 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.32013445903016 density:0.0666666666666667 bootstrap:0.52120832 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9361 ! CC: | BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:8210 name: CC: | BP: isoleucine metabolic process | MF:dihydroxy-acid dehydratase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. | MF_def:Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:2.59186808967019 density:0.666666666666667 bootstrap:0.612207618 cc_score:0.0 bp_score:0.101645 mf_score:0.269396 relationship: child_of NeXO:9358 ! CC: | BP: regulation of growth | MF: relationship: linked_to NeXO:9567 ! CC: | BP: | MF: [Term] id: NeXO:8213 name: CC: | BP: acetyl-CoA biosynthetic process | MF:pyruvate dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. | MF_def:Catalysis of the oxidative decarboxylation of pyruvate." [NeXO-GO:term] namespace: NeXO comment: robustness:13.8148437372066 density:0.59047619047619 bootstrap:0.624055309 cc_score:0.0 bp_score:0.1992 mf_score:0.119593 relationship: child_of NeXO:8801 ! CC: | BP: | MF: [Term] id: NeXO:8744 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.64364943811477 density:0.9 bootstrap:0.41455565 cc_score:0.0984344 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9581 ! CC: U1 snRNP | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding relationship: linked_to NeXO:8814 ! CC: | BP: | MF: [Term] id: NeXO:8743 name: CC: | BP: GPI anchor metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.50201994086102 density:0.088235294117647 bootstrap:0.182877 cc_score:0.0 bp_score:0.136981 mf_score:0.0885016 relationship: child_of NeXO:9476 ! CC: coated pit | BP: | MF: [Term] id: NeXO:8214 name: CC: epsilon DNA polymerase complex | BP: | MF: def: "CC_def: A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16771686722916 density:1 bootstrap:0.77862252 cc_score:0.352951 bp_score:0.0154695 mf_score:0.0 relationship: child_of NeXO:9162 ! CC: DNA polymerase complex | BP: cellular response to cold | MF:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: NeXO:8741 name: CC: | BP: protein localization to nucleolar rDNA repeats | MF:rDNA spacer replication fork barrier binding def: "CC_def: | BP_def: Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus. | MF_def:Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [NeXO-GO:term] namespace: NeXO comment: robustness:0.941631592626563 density:0.333333333333333 bootstrap:0.179531685 cc_score:0.0 bp_score:0.488451 mf_score:0.319558 relationship: child_of NeXO:9164 ! CC: | BP: rDNA condensation | MF:rDNA binding relationship: linked_to NeXO:6779 ! CC: | BP: | MF: [Term] id: NeXO:8216 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.75234231903781 density:0.133333333333333 bootstrap:0.308511572 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9085 ! CC: | BP: | MF: [Term] id: NeXO:7650 name: CC: | BP: cellular response to anoxia | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03889093716888 density:0.333333333333333 bootstrap:0.841718855 cc_score:0.0 bp_score:0.151266 mf_score:0.0 relationship: child_of NeXO:8597 ! CC: | BP: | MF: relationship: linked_to NeXO:7782 ! CC: | BP: protein processing | MF:calcium-dependent cysteine-type endopeptidase activity [Term] id: NeXO:7651 name: CC: mannosyltransferase complex | BP: | MF:alpha-1,6-mannosyltransferase activity def: "CC_def: A complex that posseses mannosyltransferase activity. | BP_def: | MF_def:Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:3.56574897938204 density:1 bootstrap:0.702262879 cc_score:0.227619 bp_score:0.0437775 mf_score:0.298437 relationship: child_of NeXO:8207 ! CC: | BP: | MF: [Term] id: NeXO:7652 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.13891262560745 density:0.0818713450292398 bootstrap:0.44381424 cc_score:0.0 bp_score:0.0319089 mf_score:0.0 relationship: child_of NeXO:8889 ! CC: | BP: | MF: [Term] id: NeXO:7653 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.83305187533823 density:0.866666666666667 bootstrap:0.83129856 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8566 ! CC: mitochondrial inner membrane presequence translocase complex | BP: | MF: [Term] id: NeXO:7654 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.402605483 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8479 ! CC: clathrin coated vesicle membrane | BP: | MF: [Term] id: NeXO:7655 name: CC: | BP: protein insertion into mitochondrial membrane from inner side | MF: def: "CC_def: | BP_def: The process in which a protein is incorporated into the mitochondrial membrane from the inner side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60619938897168 density:1 bootstrap:0.427484881 cc_score:0.0 bp_score:0.149273 mf_score:0.0 relationship: child_of NeXO:7948 ! CC: | BP: | MF: relationship: linked_to NeXO:8544 ! CC: | BP: | MF: [Term] id: NeXO:7657 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.94088297500357 density:0.0588235294117647 bootstrap:0.43101195 cc_score:0.0 bp_score:0.0339098 mf_score:0.0 relationship: child_of NeXO:8869 ! CC: | BP: inorganic anion transport | MF: [Term] id: NeXO:7658 name: CC: | BP: C-terminal protein lipidation | MF:APG12 activating enzyme activity def: "CC_def: | BP_def: The covalent attachment of a lipid group to the carboxy terminus of a protein. | MF_def:Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [NeXO-GO:term] namespace: NeXO comment: robustness:3.43120414051929 density:1 bootstrap:0.65026637 cc_score:0.0 bp_score:0.255848 mf_score:0.29594 relationship: child_of NeXO:8253 ! CC: | BP: mitochondrion degradation | MF:APG8 activating enzyme activity [Term] id: NeXO:9400 name: CC: | BP: glucose catabolic process to ethanol | MF:methylglyoxal reductase (NADH-dependent) activity def: "CC_def: | BP_def: The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. | MF_def:Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:2.43630594464829 density:0.238095238095238 bootstrap:0.292587505 cc_score:0.0 bp_score:0.138504 mf_score:0.132704 relationship: child_of NeXO:9674 ! CC: | BP: glycolysis | MF: [Term] id: NeXO:7680 name: CC: | BP: | MF:importin-alpha export receptor activity def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.357422608 cc_score:0.0 bp_score:0.0 mf_score:0.293126 relationship: child_of NeXO:8132 ! CC: | BP: | MF:malate dehydrogenase (oxaloacetate-decarboxylating) activity [Term] id: NeXO:5432 name: CC: ASTRA complex | BP: | MF: def: "CC_def: A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.12214520554838 density:0.666666666666667 bootstrap:0.88833983 cc_score:0.345166 bp_score:0.0 mf_score:0.0113364 relationship: child_of NeXO:5433 ! CC: | BP: arabinose catabolic process | MF:alditol:NADP+ 1-oxidoreductase activity [Term] id: NeXO:5433 name: CC: | BP: arabinose catabolic process | MF:alditol:NADP+ 1-oxidoreductase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose. | MF_def:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.49519078103174 density:0.266666666666667 bootstrap:0.721051925 cc_score:0.0 bp_score:0.198464 mf_score:0.166168 relationship: child_of NeXO:5499 ! CC: | BP: pentose catabolic process | MF:alcohol dehydrogenase (NADP+) activity [Term] id: NeXO:5430 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88288629 cc_score:0.0 bp_score:0.0601251 mf_score:0.0 relationship: child_of NeXO:6561 ! CC: | BP: hydrogen sulfide biosynthetic process | MF:cystathionine beta-synthase activity relationship: linked_to NeXO:9102 ! CC: | BP: protein unfolding | MF: [Term] id: NeXO:6175 name: CC: | BP: triglyceride metabolic process | MF:ergosterol O-acyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. | MF_def:Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [NeXO-GO:term] namespace: NeXO comment: robustness:3.4357861201268 density:0.5 bootstrap:0.780998163 cc_score:0.0 bp_score:0.167058 mf_score:0.196743 relationship: child_of NeXO:7329 ! CC: | BP: | MF: [Term] id: NeXO:7092 name: CC: | BP: regulation of MAP kinase activity | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of MAP kinase activity. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.24564020382971 density:0.166666666666667 bootstrap:0.365152672 cc_score:0.0 bp_score:0.133322 mf_score:0.0 relationship: child_of NeXO:8136 ! CC: | BP: negative regulation of MAPKKK cascade | MF: [Term] id: NeXO:5437 name: CC: | BP: pyrimidine nucleotide transport | MF:pyrimidine nucleotide transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. | MF_def:Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.77108882 cc_score:0.0 bp_score:0.316033 mf_score:0.321827 relationship: child_of NeXO:5482 ! CC: | BP: | MF:nucleotide transmembrane transporter activity [Term] id: NeXO:7090 name: CC: PAN complex | BP: | MF: def: "CC_def: A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.51746055 cc_score:0.229845 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8136 ! CC: | BP: negative regulation of MAPKKK cascade | MF: [Term] id: NeXO:6249 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.81913678001335 density:0.333333333333333 bootstrap:0.84833462 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6580 ! CC: | BP: purine nucleotide salvage | MF: [Term] id: NeXO:5939 name: CC: | BP: | MF:flavin-containing monooxygenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.912476008 cc_score:0.0 bp_score:0.0 mf_score:0.299281 relationship: child_of NeXO:5940 ! CC: | BP: | MF: [Term] id: NeXO:9450 name: CC: | BP: deadenylation-dependent decapping of nuclear-transcribed mRNA | MF:m7G(5')pppN diphosphatase activity def: "CC_def: | BP_def: Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. | MF_def:Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [NeXO-GO:term] namespace: NeXO comment: robustness:6.86868803810895 density:1 bootstrap:0.78173323 cc_score:0.0 bp_score:0.441207 mf_score:0.219131 relationship: child_of NeXO:9659 ! CC: | BP: cytoplasmic mRNA processing body assembly | MF: [Term] id: NeXO:5439 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.04435912103484 density:0.666666666666667 bootstrap:0.8446265 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5739 ! CC: | BP: aromatic amino acid family biosynthetic process, prephenate pathway | MF: [Term] id: NeXO:7098 name: CC: | BP: | MF:delta14-sterol reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [NeXO-GO:term] namespace: NeXO comment: robustness:6.22300176373729 density:0.8 bootstrap:0.584022218 cc_score:0.0 bp_score:0.0 mf_score:0.142629 relationship: child_of NeXO:7493 ! CC: | BP: | MF:C-8 sterol isomerase activity [Term] id: NeXO:5498 name: CC: | BP: furaldehyde metabolic process | MF:hydroxymethylfurfural reductase (NADH) activity def: "CC_def: | BP_def: The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass. | MF_def:Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [NeXO-GO:term] namespace: NeXO comment: robustness:1.82236561029444 density:0.333333333333333 bootstrap:0.672434655 cc_score:0.0 bp_score:0.202633 mf_score:0.202256 relationship: child_of NeXO:5499 ! CC: | BP: pentose catabolic process | MF:alcohol dehydrogenase (NADP+) activity [Term] id: NeXO:8179 name: CC: | BP: endosome transport via multivesicular body sorting pathway | MF: def: "CC_def: | BP_def: The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.41260656304112 density:0.090909090909091 bootstrap:0.382614635 cc_score:0.0 bp_score:0.11597 mf_score:0.0 relationship: child_of NeXO:8874 ! CC: | BP: late endosome to vacuole transport | MF: [Term] id: NeXO:7635 name: CC: | BP: regulation of sporulation resulting in formation of a cellular spore | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of spore formation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.416816902 cc_score:0.0 bp_score:0.183925 mf_score:0.0 relationship: child_of NeXO:7968 ! CC: | BP: | MF: relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: relationship: linked_to NeXO:7893 ! CC: | BP: heme O biosynthetic process | MF:protoheme IX farnesyltransferase activity [Term] id: NeXO:7387 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56061064037687 density:0.0578947368421053 bootstrap:0.472010727 cc_score:0.0 bp_score:0.0281798 mf_score:0.0 relationship: child_of NeXO:7575 ! CC: | BP: | MF: [Term] id: NeXO:6322 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15064960166335 density:1 bootstrap:0.76641 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6430 ! CC: | BP: snoRNA splicing | MF: [Term] id: NeXO:8105 name: CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.30896818197159 density:0.166666666666667 bootstrap:0.40322498 cc_score:0.0 bp_score:0.0 mf_score:0.209237 relationship: child_of NeXO:8258 ! CC: | BP: | MF:cadmium ion transmembrane transporter activity relationship: linked_to NeXO:7922 ! CC: | BP: | MF: [Term] id: NeXO:9815 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.7082621120403 density:0.0718954248366013 bootstrap:0.250896526 cc_score:0.0 bp_score:0.0270386 mf_score:0.0 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: [Term] id: NeXO:8107 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.81181588732291 density:0.0467836257309941 bootstrap:0.432870812 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9390 ! CC: | BP: | MF: [Term] id: NeXO:8106 name: CC: | BP: | MF:4-alpha-glucanotransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [NeXO-GO:term] namespace: NeXO comment: robustness:2.19044401285884 density:0.190476190476190 bootstrap:0.310035434 cc_score:0.0 bp_score:0.0 mf_score:0.119364 relationship: child_of NeXO:8425 ! CC: | BP: | MF: [Term] id: NeXO:8101 name: CC: retromer complex, outer shell | BP: | MF: def: "CC_def: One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.27684563883059 density:1 bootstrap:0.85899181 cc_score:0.883829 bp_score:0.0 mf_score:0.0716388 relationship: child_of NeXO:8894 ! CC: retromer complex | BP: | MF: relationship: linked_to NeXO:9015 ! CC: | BP: Golgi vesicle fusion to target membrane | MF: [Term] id: NeXO:8100 name: CC: | BP: | MF:L-methionine-(R)-S-oxide reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [NeXO-GO:term] namespace: NeXO comment: robustness:3.22108190065712 density:0.666666666666667 bootstrap:0.94553253 cc_score:0.0 bp_score:0.0 mf_score:0.274878 relationship: child_of NeXO:8641 ! CC: | BP: regulation of mRNA export from nucleus in response to heat stress | MF: [Term] id: NeXO:8103 name: CC: myosin V complex | BP: endoplasmic reticulum inheritance | MF: def: "CC_def: A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. | BP_def: The partitioning of endoplasmic reticulum between daughter cells at cell division. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.90046858571846 density:1 bootstrap:0.84029494 cc_score:0.233552 bp_score:0.252933 mf_score:0.0 relationship: child_of NeXO:9026 ! CC: myosin complex | BP: | MF:microfilament motor activity [Term] id: NeXO:8102 name: CC: | BP: nuclear retention of unspliced pre-mRNA at the site of transcription | MF: def: "CC_def: | BP_def: The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18113755173045 density:1 bootstrap:0.78829352 cc_score:0.0 bp_score:0.294175 mf_score:0.0 relationship: child_of NeXO:8838 ! CC: | BP: cis assembly of pre-catalytic spliceosome | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding [Term] id: NeXO:5110 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8381807 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5471 ! CC: | BP: plasma membrane pyruvate transport | MF:selenite:hydrogen symporter activity [Term] id: NeXO:8109 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.23222668911397 density:0.1 bootstrap:0.40563904 cc_score:0.0 bp_score:0.0601303 mf_score:0.0 relationship: child_of NeXO:9107 ! CC: | BP: regulation of translational fidelity | MF: [Term] id: NeXO:6498 name: CC: | BP: negative regulation of lipid biosynthetic process | MF: def: "CC_def: | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.45297733104443 density:0.2 bootstrap:0.72703972 cc_score:0.0 bp_score:0.182141 mf_score:0.0 relationship: child_of NeXO:7609 ! CC: | BP: negative regulation of lipid metabolic process | MF: [Term] id: NeXO:5555 name: CC: | BP: response to purine-containing compound | MF: def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89031323 cc_score:0.0 bp_score:0.448862 mf_score:0.0 relationship: child_of NeXO:5716 ! CC: | BP: response to organic cyclic compound | MF: [Term] id: NeXO:6959 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.542383509 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7569 ! CC: | BP: | MF: [Term] id: NeXO:6488 name: CC: | BP: inactivation of MAPK activity involved in conjugation with cellular fusion | MF: def: "CC_def: | BP_def: Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.694636407 cc_score:0.0 bp_score:0.298739 mf_score:0.0 relationship: child_of NeXO:7070 ! CC: | BP: MAPKKK cascade involved in conjugation with cellular fusion | MF:calmodulin binding [Term] id: NeXO:5556 name: CC: | BP: positive regulation of glycolysis | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of glycolysis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.870942501 cc_score:0.0 bp_score:0.439283 mf_score:0.0 relationship: child_of NeXO:6171 ! CC: | BP: | MF: [Term] id: NeXO:5551 name: CC: | BP: gamma-aminobutyric acid catabolic process | MF:succinate-semialdehyde dehydrogenase [NAD(P)+] activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. | MF_def:Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:3.08443449071524 density:0.666666666666667 bootstrap:0.86700987 cc_score:0.0 bp_score:0.424336 mf_score:0.314763 relationship: child_of NeXO:6382 ! CC: | BP: glutamate decarboxylation to succinate | MF:4-aminobutyrate transaminase activity [Term] id: NeXO:5550 name: CC: | BP: | MF:kynurenine 3-monooxygenase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.863969345 cc_score:0.0 bp_score:0.0 mf_score:0.445351 relationship: child_of NeXO:5551 ! CC: | BP: gamma-aminobutyric acid catabolic process | MF:succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Term] id: NeXO:8215 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.02227520303727 density:1 bootstrap:0.67764519 cc_score:0.0 bp_score:0.0210205 mf_score:0.0 relationship: child_of NeXO:9214 ! CC: | BP: | MF: relationship: linked_to NeXO:8531 ! CC: | BP: DNA geometric change | MF: relationship: linked_to NeXO:8968 ! CC: | BP: replication fork arrest | MF: relationship: linked_to NeXO:7839 ! CC: | BP: DNA duplex unwinding | MF:single-stranded DNA-dependent ATPase activity [Term] id: NeXO:9569 name: CC: | BP: termination of RNA polymerase I transcription | MF: def: "CC_def: | BP_def: The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.31854237436364 density:0.619047619047619 bootstrap:0.602606129 cc_score:0.0 bp_score:0.162038 mf_score:0.0 relationship: child_of NeXO:9847 ! CC: | BP: chromatin remodeling | MF: [Term] id: NeXO:9861 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.99347732254742 density:0.01488852311836 bootstrap:0.123660868 cc_score:0.0393804 bp_score:0.0707355 mf_score:0.0318194 relationship: child_of NeXO:9998 ! CC: mitochondrial part | BP: localization | MF:transporter activity [Term] id: NeXO:9860 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16486383423812 density:0.0119658119658120 bootstrap:0.11022882 cc_score:0.0 bp_score:0.0382841 mf_score:0.0276502 relationship: child_of NeXO:9977 ! CC: | BP: | MF: [Term] id: NeXO:6480 name: CC: | BP: myo-inositol transport | MF:myo-inositol transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. | MF_def:Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84376344 cc_score:0.0 bp_score:0.296953 mf_score:0.299749 relationship: child_of NeXO:6983 ! CC: | BP: | MF: [Term] id: NeXO:9862 name: CC: | BP: chitin biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.5408606751665 density:0.543859649122807 bootstrap:0.41064114 cc_score:0.0564789 bp_score:0.127621 mf_score:0.0 relationship: child_of NeXO:9991 ! CC: cortical actin cytoskeleton | BP: actin filament-based process | MF:cytoskeletal protein binding [Term] id: NeXO:6954 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.26599401851969 density:1 bootstrap:0.502579823 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7737 ! CC: | BP: | MF: relationship: linked_to NeXO:9364 ! CC: | BP: | MF: [Term] id: NeXO:6955 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7903097106655 density:1 bootstrap:0.531102299 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7041 ! CC: DNA ligase IV complex | BP: | MF: [Term] id: NeXO:6484 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.713107903 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6502 ! CC: integral to mitochondrial outer membrane | BP: tRNA import into mitochondrion | MF:mitochondrion targeting sequence binding relationship: linked_to NeXO:9102 ! CC: | BP: protein unfolding | MF: [Term] id: NeXO:6957 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78722583 cc_score:0.0 bp_score:0.0409159 mf_score:0.0 relationship: child_of NeXO:7770 ! CC: | BP: | MF: [Term] id: NeXO:9682 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.21463618476842 density:0.523809523809524 bootstrap:0.331182768 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9809 ! CC: | BP: | MF: relationship: linked_to NeXO:9768 ! CC: | BP: | MF: [Term] id: NeXO:9452 name: CC: | BP: purine ribonucleoside triphosphate biosynthetic process | MF:hydrogen ion transmembrane transporter activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. | MF_def:Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:11.7467210638723 density:0.093061224489796 bootstrap:0.43824404 cc_score:0.0 bp_score:0.202031 mf_score:0.159068 relationship: child_of NeXO:9575 ! CC: small ribosomal subunit | BP: mitochondrial translation | MF: [Term] id: NeXO:9207 name: CC: | BP: positive regulation of mitochondrial translation in response to stress | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.38008892 cc_score:0.0 bp_score:0.442679 mf_score:0.0 relationship: child_of NeXO:9595 ! CC: | BP: regulation of retrograde vesicle-mediated transport, Golgi to ER | MF: [Term] id: NeXO:6949 name: CC: mitochondrial inner membrane protein insertion complex | BP: protein import into mitochondrial inner membrane | MF: def: "CC_def: A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane. | BP_def: The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.29821430595838 density:0.833333333333333 bootstrap:0.65084496 cc_score:0.584213 bp_score:0.393941 mf_score:0.0 relationship: child_of NeXO:7147 ! CC: mitochondrial intermembrane space protein transporter complex | BP: inner mitochondrial membrane organization | MF: [Term] id: NeXO:5615 name: CC: | BP: guanosine metabolic process | MF:chloride transport def: "CC_def: | BP_def: The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution. | MF_def:The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.53071177 cc_score:0.0 bp_score:0.133006 mf_score:0.281758 relationship: child_of NeXO:5744 ! CC: | BP: | MF: [Term] id: NeXO:8589 name: CC: | BP: protein localization to nuclear pore | MF: def: "CC_def: | BP_def: A process in which a protein is transported to, or maintained in, a nuclear pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.453605323 cc_score:0.0 bp_score:0.438845 mf_score:0.0 relationship: child_of NeXO:9671 ! CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: relationship: linked_to NeXO:9087 ! CC: | BP: | MF: [Term] id: NeXO:7229 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.43792915330978 density:0.2 bootstrap:0.249830839 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8179 ! CC: | BP: endosome transport via multivesicular body sorting pathway | MF: [Term] id: NeXO:5523 name: CC: | BP: low-affinity zinc ion transport | MF:low-affinity zinc ion transmembrane transporter activity def: "CC_def: | BP_def: The directed, low-affinity movement of zinc (Zn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80486176 cc_score:0.0 bp_score:0.451675 mf_score:0.449478 relationship: child_of NeXO:6110 ! CC: | BP: zinc ion transmembrane transport | MF: [Term] id: NeXO:6329 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.95327267 cc_score:0.0 bp_score:0.0988238 mf_score:0.0 relationship: child_of NeXO:7450 ! CC: | BP: | MF: [Term] id: NeXO:8581 name: CC: | BP: | MF:ribosomal large subunit binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24633887588184 density:1 bootstrap:0.83612728 cc_score:0.0 bp_score:0.0 mf_score:0.294057 relationship: child_of NeXO:8989 ! CC: | BP: folic acid biosynthetic process | MF:methenyltetrahydrofolate cyclohydrolase activity relationship: linked_to NeXO:9533 ! CC: | BP: | MF: [Term] id: NeXO:8580 name: CC: ribonuclease H2 complex | BP: | MF: def: "CC_def: A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95809354814595 density:1 bootstrap:0.63531443 cc_score:0.218795 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9268 ! CC: | BP: | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:8732 ! CC: | BP: response to hydroperoxide | MF: [Term] id: NeXO:8583 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.5617430072243 density:0.666666666666667 bootstrap:0.591807898 cc_score:0.0 bp_score:0.0853707 mf_score:0.0 relationship: child_of NeXO:9267 ! CC: | BP: | MF: [Term] id: NeXO:6328 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3074896737632 density:1 bootstrap:0.88226973 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7460 ! CC: | BP: enzyme-directed rRNA pseudouridine synthesis | MF: relationship: linked_to NeXO:6929 ! CC: | BP: | MF: relationship: linked_to NeXO:8994 ! CC: | BP: | MF: [Term] id: NeXO:9817 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.93148432976237 density:0.163742690058480 bootstrap:0.368070853 cc_score:0.0 bp_score:0.0398612 mf_score:0.0 relationship: child_of NeXO:10005 ! CC: cytosolic large ribosomal subunit | BP: | MF: [Term] id: NeXO:8587 name: CC: | BP: spliceosome disassembly | MF: def: "CC_def: | BP_def: Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35164470244767 density:1 bootstrap:0.91635818 cc_score:0.0 bp_score:0.356094 mf_score:0.0 relationship: child_of NeXO:9414 ! CC: | BP: ribonucleoprotein complex disassembly | MF: relationship: linked_to NeXO:8813 ! CC: Prp19 complex | BP: | MF:first spliceosomal transesterification activity relationship: linked_to NeXO:9489 ! CC: | BP: | MF: relationship: linked_to NeXO:9733 ! CC: trans spliceosomal complex | BP: spliceosomal snRNP assembly | MF: relationship: linked_to NeXO:9567 ! CC: | BP: | MF: [Term] id: NeXO:8586 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.93326666174516 density:0.163636363636364 bootstrap:0.270207508 cc_score:0.0 bp_score:0.0230532 mf_score:0.0 relationship: child_of NeXO:9370 ! CC: | BP: | MF: [Term] id: NeXO:5757 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.48978580645776 density:0.333333333333333 bootstrap:0.661696548 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5786 ! CC: | BP: | MF: [Term] id: NeXO:8363 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.20243532393328 density:0.166666666666667 bootstrap:0.340261413 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8872 ! CC: | BP: | MF: [Term] id: NeXO:8362 name: CC: | BP: snoRNA metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.3124382372465 density:0.138461538461538 bootstrap:0.276117313 cc_score:0.0391556 bp_score:0.10182 mf_score:0.0838594 relationship: child_of NeXO:9334 ! CC: | BP: | MF: [Term] id: NeXO:8365 name: CC: | BP: RNA capping | MF: def: "CC_def: | BP_def: The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.449542532 cc_score:0.0 bp_score:0.141075 mf_score:0.0 relationship: child_of NeXO:9459 ! CC: | BP: | MF: [Term] id: NeXO:8382 name: CC: | BP: | MF:inositol hexakisphosphate binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with inositol hexakisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.58979164272069 density:0.333333333333333 bootstrap:0.511751924 cc_score:0.0 bp_score:0.0864741 mf_score:0.565944 relationship: child_of NeXO:8549 ! CC: | BP: poly(A)+ mRNA export from nucleus | MF: [Term] id: NeXO:8367 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.15528078792177 density:0.107142857142857 bootstrap:0.461954724 cc_score:0.0 bp_score:0.0267105 mf_score:0.0 relationship: child_of NeXO:9957 ! CC: nuclear pore | BP: protein import into nucleus | MF:nucleocytoplasmic transport [Term] id: NeXO:8366 name: CC: protein serine/threonine phosphatase complex | BP: glucan biosynthetic process | MF:protein phosphatase type 1 regulator activity def: "CC_def: A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. | BP_def: The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. | MF_def:Modulation of the activity of the enzyme protein phosphatase type 1." [NeXO-GO:term] namespace: NeXO comment: robustness:3.53550177962616 density:0.098901098901099 bootstrap:0.461151687 cc_score:0.132155 bp_score:0.128773 mf_score:0.258373 relationship: child_of NeXO:9142 ! CC: | BP: glycogen metabolic process | MF:protein phosphatase regulator activity [Term] id: NeXO:8369 name: CC: | BP: | MF:UDP-N-acetylglucosamine diphosphorylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.270320224 cc_score:0.0 bp_score:0.0926574 mf_score:0.256654 relationship: child_of NeXO:8802 ! CC: | BP: | MF: [Term] id: NeXO:8368 name: CC: | BP: | MF:lysophosphatidic acid phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [NeXO-GO:term] namespace: NeXO comment: robustness:2.15879136688241 density:1 bootstrap:0.772223817 cc_score:0.0 bp_score:0.0 mf_score:0.438316 relationship: child_of NeXO:9131 ! CC: | BP: | MF: relationship: linked_to NeXO:9567 ! CC: | BP: | MF: relationship: linked_to NeXO:7699 ! CC: | BP: L-serine catabolic process | MF:L-threonine ammonia-lyase activity relationship: linked_to NeXO:6949 ! CC: mitochondrial inner membrane protein insertion complex | BP: protein import into mitochondrial inner membrane | MF: relationship: linked_to NeXO:6199 ! CC: | BP: | MF: [Term] id: NeXO:5527 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89717619 cc_score:0.0 bp_score:0.0 mf_score:0.0109388 relationship: child_of NeXO:6717 ! CC: | BP: | MF: [Term] id: NeXO:5883 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71968469 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6414 ! CC: | BP: | MF: [Term] id: NeXO:5882 name: CC: AMP-activated protein kinase complex | BP: | MF:AMP-activated protein kinase activity def: "CC_def: A protein complex that possesses AMP-dependent protein kinase activity. | BP_def: | MF_def:Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [NeXO-GO:term] namespace: NeXO comment: robustness:2.24463231775051 density:1 bootstrap:0.83485734 cc_score:0.350054 bp_score:0.0515463 mf_score:0.350658 relationship: child_of NeXO:6201 ! CC: | BP: | MF: [Term] id: NeXO:5881 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90746419 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6722 ! CC: | BP: | MF: [Term] id: NeXO:5880 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84437188 cc_score:0.0879234 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7008 ! CC: | BP: | MF: [Term] id: NeXO:8563 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.49089250615477 density:1 bootstrap:0.83262692 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9426 ! CC: | BP: | MF: relationship: linked_to NeXO:9295 ! CC: | BP: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF:LSU rRNA binding [Term] id: NeXO:8562 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.79482726112859 density:0.0409982174688057 bootstrap:0.309512078 cc_score:0.0303686 bp_score:0.0100993 mf_score:0.0221069 relationship: child_of NeXO:9300 ! CC: | BP: | MF: [Term] id: NeXO:5885 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.23991989541543 density:1 bootstrap:0.83135559 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6723 ! CC: | BP: | MF: [Term] id: NeXO:5529 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.24989414335739 density:1 bootstrap:0.838776042 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5788 ! CC: | BP: | MF: [Term] id: NeXO:5889 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.855864829 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6103 ! CC: | BP: | MF: [Term] id: NeXO:9810 name: CC: | BP: histone phosphorylation | MF: def: "CC_def: | BP_def: The modification of histones by addition of phosphate groups. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.914965894518 density:0.416666666666667 bootstrap:0.22494798 cc_score:0.0 bp_score:0.174238 mf_score:0.0 relationship: child_of NeXO:9899 ! CC: | BP: DNA damage checkpoint | MF:double-stranded DNA binding [Term] id: NeXO:5643 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81066511 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6439 ! CC: | BP: | MF: [Term] id: NeXO:5756 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.98207851729622 density:0.666666666666667 bootstrap:0.81042175 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5757 ! CC: | BP: | MF: [Term] id: NeXO:6554 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.52436727223337 density:0.2 bootstrap:0.76997416 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6836 ! CC: | BP: | MF: [Term] id: NeXO:6555 name: CC: | BP: negative regulation of conjugation with cellular fusion | MF: def: "CC_def: | BP_def: Any process that decreases the rate or frequency of conjugation with cellular fusion. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.24344818331656 density:0.0476190476190476 bootstrap:0.512934757 cc_score:0.0 bp_score:0.136377 mf_score:0.0620748 relationship: child_of NeXO:7235 ! CC: | BP: | MF: [Term] id: NeXO:6556 name: CC: | BP: | MF:siderophore uptake transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.97112118180716 density:1 bootstrap:0.64379633 cc_score:0.0 bp_score:0.0 mf_score:0.454511 relationship: child_of NeXO:7191 ! CC: | BP: siderophore transport | MF:siderophore transport relationship: linked_to NeXO:6156 ! CC: | BP: | MF: [Term] id: NeXO:6557 name: CC: | BP: glucose 1-phosphate metabolic process | MF:phosphoglucomutase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1. | MF_def:Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.627624531 cc_score:0.0 bp_score:0.176238 mf_score:0.178778 relationship: child_of NeXO:7608 ! CC: | BP: | MF: [Term] id: NeXO:6550 name: CC: | BP: | MF:tRNA (m5U54) methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:1.4768588356498 density:0.1 bootstrap:0.582688565 cc_score:0.0 bp_score:0.0 mf_score:0.219075 relationship: child_of NeXO:7077 ! CC: | BP: | MF:double-stranded DNA specific 5'-3' exodeoxyribonuclease activity [Term] id: NeXO:9067 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32634676329872 density:0.6 bootstrap:0.358405581 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9573 ! CC: mitochondrial large ribosomal subunit | BP: | MF: relationship: linked_to NeXO:8163 ! CC: | BP: | MF: relationship: linked_to NeXO:8162 ! CC: | BP: | MF: relationship: linked_to NeXO:8161 ! CC: | BP: | MF: [Term] id: NeXO:6552 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.98779315176998 density:0.3 bootstrap:0.66967463 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6911 ! CC: | BP: | MF: [Term] id: NeXO:9965 name: CC: Golgi apparatus | BP: Golgi vesicle transport | MF: def: "CC_def: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. | BP_def: The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.0895631851384 density:0.08895023387777 bootstrap:0.4969733 cc_score:0.203142 bp_score:0.26227 mf_score:0.0760731 relationship: child_of NeXO:9981 ! CC: endosome | BP: vesicle-mediated transport | MF:protein transport [Term] id: NeXO:5645 name: CC: | BP: phosphatidylcholine catabolic process | MF:heme transport def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. | MF_def:The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.747335246 cc_score:0.0 bp_score:0.441999 mf_score:0.175 relationship: child_of NeXO:6049 ! CC: | BP: amide biosynthetic process | MF:cyclo-ligase activity [Term] id: NeXO:6558 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.69474042906482 density:0.2 bootstrap:0.60481374 cc_score:0.0 bp_score:0.094943 mf_score:0.0 relationship: child_of NeXO:7322 ! CC: | BP: | MF: [Term] id: NeXO:6559 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.96359243936649 density:0.333333333333333 bootstrap:0.780695664 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7327 ! CC: | BP: | MF: [Term] id: NeXO:9720 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.46223105376095 density:0.0301010101010101 bootstrap:0.121456053 cc_score:0.0231445 bp_score:0.0443993 mf_score:0.0403151 relationship: child_of NeXO:9861 ! CC: | BP: | MF: [Term] id: NeXO:7479 name: CC: elongin complex | BP: | MF: def: "CC_def: A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30110074553352 density:0.5 bootstrap:0.350323311 cc_score:0.436843 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7480 ! CC: | BP: | MF: [Term] id: NeXO:9967 name: CC: nuclear chromatin | BP: | MF: def: "CC_def: The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.5137058657384 density:0.194727891156463 bootstrap:0.418308971 cc_score:0.138985 bp_score:0.0684841 mf_score:0.0413637 relationship: child_of NeXO:9982 ! CC: chromatin remodeling complex | BP: nucleosome organization | MF: [Term] id: NeXO:9811 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:17.1219446812159 density:0.891666666666667 bootstrap:0.483002045 cc_score:0.0 bp_score:0.0544799 mf_score:0.0 relationship: child_of NeXO:9839 ! CC: | BP: | MF: [Term] id: NeXO:7472 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.85014313838189 density:1 bootstrap:0.567195146 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8786 ! CC: | BP: | MF: relationship: linked_to NeXO:8517 ! CC: | BP: | MF: relationship: linked_to NeXO:9564 ! CC: | BP: | MF: [Term] id: NeXO:5646 name: CC: | BP: cytidine metabolic process | MF:cytosine deaminase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside. | MF_def:Catalysis of the reaction: cytosine + H2O = uracil + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87115841 cc_score:0.0 bp_score:0.296283 mf_score:0.439951 relationship: child_of NeXO:7516 ! CC: | BP: cytosine metabolic process | MF: [Term] id: NeXO:5755 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.36434288273179 density:1 bootstrap:0.92628102 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7887 ! CC: | BP: | MF: [Term] id: NeXO:7475 name: CC: external side of endosome membrane | BP: | MF:phosphatidylinositol phosphate kinase activity def: "CC_def: The external (cytoplasmic face) of an endosome membrane. | BP_def: | MF_def:Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.83201926413497 density:0.833333333333333 bootstrap:0.822543225 cc_score:0.250605 bp_score:0.0 mf_score:0.158285 relationship: child_of NeXO:8116 ! CC: PAS complex | BP: positive regulation of kinase activity | MF:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [Term] id: NeXO:7476 name: CC: | BP: | MF:mannose transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [NeXO-GO:term] namespace: NeXO comment: robustness:6.7353469491453 density:1 bootstrap:0.751676431 cc_score:0.0 bp_score:0.0950232 mf_score:0.275131 relationship: child_of NeXO:8123 ! CC: | BP: glucose transport | MF:glucose transmembrane transporter activity [Term] id: NeXO:7477 name: CC: | BP: tRNA wobble position uridine thiolation | MF:URM1 activating enzyme activity def: "CC_def: | BP_def: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. | MF_def:Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [NeXO-GO:term] namespace: NeXO comment: robustness:14.2419492567818 density:0.933333333333333 bootstrap:0.83146691 cc_score:0.0 bp_score:0.310303 mf_score:0.139777 relationship: child_of NeXO:9462 ! CC: | BP: tRNA wobble uridine modification | MF: [Term] id: NeXO:7119 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90241005 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9122 ! CC: | BP: | MF: [Term] id: NeXO:9962 name: CC: | BP: modification-dependent protein catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:15.8112184527877 density:0.102419238012458 bootstrap:0.34093513 cc_score:0.086773 bp_score:0.150592 mf_score:0.0675115 relationship: child_of NeXO:10032 ! CC: intracellular | BP: metabolic process | MF:catalytic activity [Term] id: NeXO:5248 name: CC: | BP: regulation of ergosterol biosynthetic process | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75755792 cc_score:0.0 bp_score:0.151236 mf_score:0.0 relationship: child_of NeXO:5462 ! CC: | BP: | MF: [Term] id: NeXO:6639 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.692412931 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7326 ! CC: | BP: | MF: [Term] id: NeXO:6638 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72729727 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8200 ! CC: | BP: regulation of exocytosis | MF: [Term] id: NeXO:5972 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.748413315 cc_score:0.0 bp_score:0.0192421 mf_score:0.0202192 relationship: child_of NeXO:6959 ! CC: | BP: | MF: [Term] id: NeXO:5824 name: CC: | BP: RNA folding | MF: def: "CC_def: | BP_def: The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.86282962345131 density:0.2 bootstrap:0.682619637 cc_score:0.0 bp_score:0.133801 mf_score:0.0 relationship: child_of NeXO:6578 ! CC: | BP: | MF: [Term] id: NeXO:6633 name: CC: | BP: maintenance of RNA location | MF: def: "CC_def: | BP_def: Any process in which RNA is maintained in a location and prevented from moving elsewhere. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.725228074 cc_score:0.0 bp_score:0.292583 mf_score:0.0 relationship: child_of NeXO:7137 ! CC: | BP: | MF: [Term] id: NeXO:6632 name: CC: | BP: regulation of histone acetylation | MF:acetyltransferase activator activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. | MF_def:Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.546155985 cc_score:0.0 bp_score:0.112493 mf_score:0.438215 relationship: child_of NeXO:7372 ! CC: | BP: heterochromatin formation involved in chromatin silencing | MF: [Term] id: NeXO:6635 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.53986014161281 density:0.333333333333333 bootstrap:0.48011096 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7300 ! CC: | BP: | MF: [Term] id: NeXO:6634 name: CC: | BP: | MF:Ran GTPase binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.54920423 cc_score:0.0 bp_score:0.0 mf_score:0.178648 relationship: child_of NeXO:6635 ! CC: | BP: | MF: [Term] id: NeXO:6637 name: CC: | BP: lysyl-tRNA aminoacylation | MF:lysine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.693937397 cc_score:0.0 bp_score:0.282845 mf_score:0.292781 relationship: child_of NeXO:7600 ! CC: | BP: | MF:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: NeXO:6636 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.24170365929661 density:1 bootstrap:0.83268022 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7781 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7562 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.449778734 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8873 ! CC: | BP: | MF:protein-arginine omega-N monomethyltransferase activity [Term] id: NeXO:7022 name: CC: | BP: monooxygenase activity | MF:C-22 sterol desaturase activity def: "CC_def: | BP_def: Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. | MF_def:Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.86518845 cc_score:0.0 bp_score:0.194444 mf_score:0.445136 relationship: child_of NeXO:7959 ! CC: | BP: | MF:sterol 14-demethylase activity [Term] id: NeXO:7504 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.70049838304409 density:0.4 bootstrap:0.728208013 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8434 ! CC: | BP: | MF: [Term] id: NeXO:7505 name: CC: | BP: regulation of dipeptide transport | MF: def: "CC_def: | BP_def: Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.347054482 cc_score:0.0 bp_score:0.133559 mf_score:0.0 relationship: child_of NeXO:8460 ! CC: | BP: | MF: [Term] id: NeXO:9885 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.8449135531055 density:0.00730048116807699 bootstrap:0.145757861 cc_score:0.0631477 bp_score:0.0736766 mf_score:0.054137 relationship: child_of NeXO:9998 ! CC: mitochondrial part | BP: localization | MF:transporter activity [Term] id: NeXO:7507 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.837050896271093 density:0.0277777777777778 bootstrap:0.281035318 cc_score:0.0 bp_score:0.0164256 mf_score:0.0 relationship: child_of NeXO:8619 ! CC: | BP: | MF: [Term] id: NeXO:9883 name: CC: large ribosomal subunit | BP: cellular monovalent inorganic cation homeostasis | MF: def: "CC_def: The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). | BP_def: Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.79914910145005 density:0.0724405239240845 bootstrap:0.141983152 cc_score:0.119061 bp_score:0.125361 mf_score:0.0746437 relationship: child_of NeXO:9960 ! CC: | BP: | MF: [Term] id: NeXO:9813 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.84117998375581 density:0.0639344262295082 bootstrap:0.122410047 cc_score:0.0275451 bp_score:0.0844338 mf_score:0.0932667 relationship: child_of NeXO:9923 ! CC: | BP: | MF: [Term] id: NeXO:9881 name: CC: Rpd3L-Expanded complex | BP: negative regulation of chromatin silencing at telomere | MF:histone deacetylation def: "CC_def: A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres. | MF_def:The modification of histones by removal of acetyl groups." [NeXO-GO:term] namespace: NeXO comment: robustness:10.7231734530546 density:0.202651515151515 bootstrap:0.299495544 cc_score:0.33981 bp_score:0.202057 mf_score:0.196584 relationship: child_of NeXO:9982 ! CC: chromatin remodeling complex | BP: nucleosome organization | MF: [Term] id: NeXO:9880 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.62557688161369 density:0.0502379693283977 bootstrap:0.10479204 cc_score:0.0 bp_score:0.0477914 mf_score:0.0350298 relationship: child_of NeXO:9947 ! CC: | BP: | MF: [Term] id: NeXO:5974 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84850822 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7992 ! CC: | BP: proton-transporting ATP synthase complex biogenesis | MF: [Term] id: NeXO:7508 name: CC: nucleus-vacuole junction | BP: nucleus-vacuole junction assembly | MF: def: "CC_def: An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. | BP_def: The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.3890938233791 density:0.5 bootstrap:0.377627994 cc_score:0.254019 bp_score:0.251009 mf_score:0.0 relationship: child_of NeXO:7629 ! CC: | BP: | MF: [Term] id: NeXO:7509 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.57085981616418 density:0.333333333333333 bootstrap:0.499636233 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7529 ! CC: | BP: | MF: relationship: linked_to NeXO:8931 ! CC: | BP: | MF: [Term] id: NeXO:9888 name: CC: | BP: | MF:translational initiation def: "CC_def: | BP_def: | MF_def:The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [NeXO-GO:term] namespace: NeXO comment: robustness:8.46329681154243 density:0.125641025641026 bootstrap:0.237573265 cc_score:0.0 bp_score:0.022918 mf_score:0.212101 relationship: child_of NeXO:9943 ! CC: | BP: | MF:translation factor activity, nucleic acid binding [Term] id: NeXO:5064 name: CC: | BP: | MF:glycerone-phosphate O-acyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.867962022 cc_score:0.0 bp_score:0.0 mf_score:0.295202 relationship: child_of NeXO:6163 ! CC: | BP: | MF:cyclin-dependent protein kinase activating kinase activity [Term] id: NeXO:9843 name: CC: mediator complex | BP: negative regulation of transcription from RNA polymerase II promoter | MF:RNA polymerase II transcription factor binding transcription factor activity def: "CC_def: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. | BP_def: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. | MF_def:Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [NeXO-GO:term] namespace: NeXO comment: robustness:22.7263496394043 density:0.74928774928775 bootstrap:0.704369339 cc_score:0.6816 bp_score:0.130016 mf_score:0.230276 relationship: child_of NeXO:9988 ! CC: DNA-directed RNA polymerase II, holoenzyme | BP: RNA polymerase II transcriptional preinitiation complex assembly | MF:RNA polymerase II transcriptional preinitiation complex assembly [Term] id: NeXO:5796 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.97983720563896 density:0.333333333333333 bootstrap:0.79366646 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6386 ! CC: | BP: | MF: [Term] id: NeXO:6125 name: CC: transcription factor TFIIIC complex | BP: | MF: def: "CC_def: A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.4697599675967 density:1 bootstrap:0.92453697 cc_score:0.652864 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7083 ! CC: | BP: DNA-dependent transcriptional open complex formation | MF:TFIIIB-type transcription factor activity [Term] id: NeXO:6124 name: CC: transcription factor TFIIIB complex | BP: transposon integration | MF:TFIIIC-class transcription factor binding def: "CC_def: A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. | BP_def: Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome. | MF_def:Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [NeXO-GO:term] namespace: NeXO comment: robustness:1.87630764495225 density:1 bootstrap:0.583350995 cc_score:0.588656 bp_score:0.569426 mf_score:0.586601 relationship: child_of NeXO:7083 ! CC: | BP: DNA-dependent transcriptional open complex formation | MF:TFIIIB-type transcription factor activity [Term] id: NeXO:6126 name: CC: | BP: spermidine transport | MF:spermidine transmembrane transporter activity def: "CC_def: | BP_def: The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:1.97099949016943 density:1 bootstrap:0.64371684 cc_score:0.0 bp_score:0.178648 mf_score:0.17902 relationship: child_of NeXO:6981 ! CC: | BP: | MF: [Term] id: NeXO:6120 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.596849244 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7108 ! CC: | BP: | MF: [Term] id: NeXO:6122 name: CC: | BP: eisosome assembly | MF:sphingolipid binding def: "CC_def: | BP_def: The aggregation, arrangement and bonding together of a set of components to form an eisosome, a large immobile protein complex that forms at the plasma membrane and marks endocytic sites. | MF_def:Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [NeXO-GO:term] namespace: NeXO comment: robustness:2.28360859920653 density:1 bootstrap:0.86410235 cc_score:0.0 bp_score:0.250627 mf_score:0.439009 relationship: child_of NeXO:7768 ! CC: | BP: establishment or maintenance of actin cytoskeleton polarity | MF:phosphatidylinositol-4,5-bisphosphate binding relationship: linked_to NeXO:8787 ! CC: | BP: | MF: [Term] id: NeXO:6129 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.07626165556134 density:0.666666666666667 bootstrap:0.86242132 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6130 ! CC: nuclear inner membrane | BP: | MF: [Term] id: NeXO:6128 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.878459546 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6129 ! CC: | BP: | MF: [Term] id: NeXO:5754 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8216578 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7522 ! CC: | BP: regulation of mating type switching | MF: [Term] id: NeXO:7486 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82976224 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7925 ! CC: N-terminal protein acetyltransferase complex | BP: N-terminal protein amino acid acetylation | MF:peptide alpha-N-acetyltransferase activity [Term] id: NeXO:6968 name: CC: | BP: | MF:polynucleotide 3'-phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [NeXO-GO:term] namespace: NeXO comment: robustness:3.20326433638252 density:0.5 bootstrap:0.678864858 cc_score:0.0 bp_score:0.0 mf_score:0.256654 relationship: child_of NeXO:7240 ! CC: | BP: | MF: [Term] id: NeXO:6362 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.857335216 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6363 ! CC: | BP: | MF: [Term] id: NeXO:9668 name: CC: | BP: microtubule depolymerization | MF: def: "CC_def: | BP_def: The removal of tubulin heterodimers from one or both ends of a microtubule. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.5694842616466 density:1 bootstrap:0.51414392 cc_score:0.0968024 bp_score:0.12356 mf_score:0.0862895 relationship: child_of NeXO:9866 ! CC: | BP: mitotic cell cycle G2/M transition checkpoint | MF: relationship: linked_to NeXO:9703 ! CC: | BP: | MF: [Term] id: NeXO:5663 name: CC: | BP: | MF:NADPH:quinone reductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.780655017 cc_score:0.0 bp_score:0.0 mf_score:0.442436 relationship: child_of NeXO:6744 ! CC: | BP: second-messenger-mediated signaling | MF:diacylglycerol kinase activity [Term] id: NeXO:5758 name: CC: | BP: regulation of transcription from RNA polymerase II promoter in response to oxidative stress | MF:amidase activity def: "CC_def: | BP_def: Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. | MF_def:Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85582007 cc_score:0.0 bp_score:0.147054 mf_score:0.439032 relationship: child_of NeXO:5759 ! CC: | BP: | MF:mannitol dehydrogenase activity relationship: linked_to NeXO:7065 ! CC: | BP: | MF: [Term] id: NeXO:8875 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.405179668 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9362 ! CC: | BP: | MF: relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:8874 name: CC: | BP: late endosome to vacuole transport | MF: def: "CC_def: | BP_def: The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:13.297884260042 density:0.219576719576720 bootstrap:0.578353536 cc_score:0.0 bp_score:0.143707 mf_score:0.0 relationship: child_of NeXO:9918 ! CC: | BP: | MF: [Term] id: NeXO:6011 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.82750181 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6643 ! CC: | BP: | MF: [Term] id: NeXO:6010 name: CC: | BP: regulation of DNA replication involved in S phase | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of DNA replication that contributes to the progression through S phase of the cell cycle. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.70330321015312 density:1 bootstrap:0.757489684 cc_score:0.0 bp_score:0.178052 mf_score:0.0 relationship: child_of NeXO:6388 ! CC: | BP: | MF: relationship: linked_to NeXO:7605 ! CC: | BP: nucleosome positioning | MF: relationship: linked_to NeXO:8876 ! CC: | BP: chromatin remodeling at centromere | MF: [Term] id: NeXO:6013 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.11201373796245 density:0.333333333333333 bootstrap:0.90317632 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7261 ! CC: | BP: | MF: [Term] id: NeXO:6012 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.588728976 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6229 ! CC: | BP: | MF:arginine transport [Term] id: NeXO:6014 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.22505990703494 density:0.666666666666667 bootstrap:0.94786942 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6554 ! CC: | BP: | MF: [Term] id: NeXO:7480 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31578927188571 density:0.111111111111111 bootstrap:0.330239748 cc_score:0.0 bp_score:0.0812625 mf_score:0.0 relationship: child_of NeXO:8502 ! CC: | BP: | MF: [Term] id: NeXO:6016 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87627055025334 density:0.166666666666667 bootstrap:0.82847646 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6456 ! CC: | BP: | MF: [Term] id: NeXO:6019 name: CC: | BP: | MF:2-isopropylmalate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75780251 cc_score:0.0 bp_score:0.0 mf_score:0.232604 relationship: child_of NeXO:6745 ! CC: | BP: | MF: [Term] id: NeXO:6018 name: CC: high affinity iron permease complex | BP: iron ion transmembrane transport | MF: def: "CC_def: A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. | BP_def: A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.94486997196567 density:0.333333333333333 bootstrap:0.76587908 cc_score:0.229963 bp_score:0.123544 mf_score:0.0 relationship: child_of NeXO:7191 ! CC: | BP: siderophore transport | MF:siderophore transport [Term] id: NeXO:9453 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.7908795521737 density:0.0163622526636225 bootstrap:0.159387431 cc_score:0.0 bp_score:0.0514367 mf_score:0.0392897 relationship: child_of NeXO:9766 ! CC: | BP: | MF: [Term] id: NeXO:8559 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.93687397559159 density:0.5 bootstrap:0.570648122 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9010 ! CC: | BP: | MF: [Term] id: NeXO:7898 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.60376091118953 density:1 bootstrap:0.42618788 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8363 ! CC: | BP: | MF: relationship: linked_to NeXO:9366 ! CC: | BP: extrachromosomal circular DNA localization involved in cell aging | MF:cytoskeletal regulatory protein binding [Term] id: NeXO:8878 name: CC: | BP: | MF:SNAP receptor activity def: "CC_def: | BP_def: | MF_def:Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [NeXO-GO:term] namespace: NeXO comment: robustness:4.9247690962032 density:0.244444444444444 bootstrap:0.55856511 cc_score:0.0 bp_score:0.0538509 mf_score:0.162876 relationship: child_of NeXO:9458 ! CC: | BP: | MF: [Term] id: NeXO:7896 name: CC: | BP: FAD transport | MF:4-hydroxybenzoate decaprenyltransferase activity def: "CC_def: | BP_def: The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. | MF_def:Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.13785901812827 density:1 bootstrap:0.75732095 cc_score:0.0 bp_score:0.177994 mf_score:0.440746 relationship: child_of NeXO:8636 ! CC: | BP: | MF:4-hydroxybenzoate nonaprenyltransferase activity relationship: linked_to NeXO:8565 ! CC: | BP: response to redox state | MF: [Term] id: NeXO:7897 name: CC: | BP: positive regulation of meiosis | MF:cyclosporin A binding def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of meiosis. | MF_def:Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [NeXO-GO:term] namespace: NeXO comment: robustness:1.95493255229238 density:1 bootstrap:0.63326488 cc_score:0.0 bp_score:0.293275 mf_score:0.441621 relationship: child_of NeXO:7976 ! CC: | BP: | MF: relationship: linked_to NeXO:9282 ! CC: Set3 complex | BP: positive regulation of stress-activated MAPK cascade | MF:NAD-independent histone deacetylase activity [Term] id: NeXO:7894 name: CC: CCAAT-binding factor complex | BP: regulation of cellular respiration | MF: def: "CC_def: A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. | BP_def: Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.91313665914892 density:1 bootstrap:0.6064763 cc_score:0.438985 bp_score:0.294635 mf_score:0.0242217 relationship: child_of NeXO:8077 ! CC: | BP: carbon catabolite activation of transcription from RNA polymerase II promoter | MF: relationship: linked_to NeXO:6869 ! CC: | BP: | MF: relationship: linked_to NeXO:7893 ! CC: | BP: heme O biosynthetic process | MF:protoheme IX farnesyltransferase activity [Term] id: NeXO:7895 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.09924678760246 density:0.866666666666667 bootstrap:0.682840969 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8848 ! CC: | BP: | MF: [Term] id: NeXO:8052 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.23463986282467 density:0.0761904761904762 bootstrap:0.41990481 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8797 ! CC: | BP: | MF: [Term] id: NeXO:7893 name: CC: | BP: heme O biosynthetic process | MF:protoheme IX farnesyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. | MF_def:Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.48402004882412 density:1 bootstrap:0.67043931 cc_score:0.0 bp_score:0.29315 mf_score:0.296629 relationship: child_of NeXO:8848 ! CC: | BP: | MF: relationship: linked_to NeXO:7530 ! CC: | BP: | MF: [Term] id: NeXO:7890 name: CC: | BP: long-chain fatty acid transport | MF:fatty acid ligase activity def: "CC_def: | BP_def: The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12. | MF_def:Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [NeXO-GO:term] namespace: NeXO comment: robustness:3.95095339612772 density:0.321428571428571 bootstrap:0.404308237 cc_score:0.0 bp_score:0.16139 mf_score:0.361928 relationship: child_of NeXO:7926 ! CC: | BP: | MF:ligase activity, forming carbon-sulfur bonds [Term] id: NeXO:5159 name: CC: | BP: response to singlet oxygen | MF:formate dehydrogenase (NAD+) activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. | MF_def:Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88519069 cc_score:0.0 bp_score:0.221386 mf_score:0.221081 relationship: child_of NeXO:5162 ! CC: | BP: formate catabolic process | MF: [Term] id: NeXO:9262 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.06802330425002 density:0.0261437908496732 bootstrap:0.151687695 cc_score:0.0 bp_score:0.0278069 mf_score:0.0 relationship: child_of NeXO:9634 ! CC: | BP: | MF: [Term] id: NeXO:9261 name: CC: heterochromatin | BP: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: A compact and highly condensed form of chromatin. | BP_def: Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.48167587996271 density:0.785714285714286 bootstrap:0.599727876 cc_score:0.119676 bp_score:0.110971 mf_score:0.0 relationship: child_of NeXO:9689 ! CC: preribosome, small subunit precursor | BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9259 ! CC: t-UTP complex | BP: positive regulation of transcription from RNA polymerase I promoter | MF: [Term] id: NeXO:9267 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.25534058833655 density:0.866666666666667 bootstrap:0.374193946 cc_score:0.0 bp_score:0.0605447 mf_score:0.0 relationship: child_of NeXO:9348 ! CC: | BP: | MF: [Term] id: NeXO:9266 name: CC: mismatch repair complex | BP: meiotic mismatch repair | MF:mismatched DNA binding def: "CC_def: Any complex formed of proteins that act in mismatch repair. | BP_def: A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. | MF_def:Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [NeXO-GO:term] namespace: NeXO comment: robustness:7.17019284569348 density:0.607142857142857 bootstrap:0.5996069 cc_score:0.434856 bp_score:0.263801 mf_score:0.560064 relationship: child_of NeXO:9603 ! CC: synaptonemal complex | BP: gene conversion at mating-type locus | MF:DNA secondary structure binding [Term] id: NeXO:9265 name: CC: | BP: negative regulation of spindle pole body separation | MF: def: "CC_def: | BP_def: Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.284107321 cc_score:0.0 bp_score:0.30253 mf_score:0.0994342 relationship: child_of NeXO:9819 ! CC: | BP: regulation of spindle pole body separation | MF:cyclin-dependent protein kinase regulator activity relationship: linked_to NeXO:9344 ! CC: | BP: fungal-type cell wall chitin biosynthetic process | MF: relationship: linked_to NeXO:9456 ! CC: | BP: regulation of cytokinesis | MF: relationship: linked_to NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: relationship: linked_to NeXO:8695 ! CC: | BP: | MF: relationship: linked_to NeXO:9216 ! CC: | BP: | MF: [Term] id: NeXO:9264 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.31610752459207 density:1 bootstrap:0.607372868 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9638 ! CC: NuA4 histone acetyltransferase complex | BP: | MF: relationship: linked_to NeXO:9508 ! CC: | BP: | MF:ATP-dependent 3'-5' DNA helicase activity relationship: linked_to NeXO:8346 ! CC: Piccolo NuA4 histone acetyltransferase complex | BP: | MF:H4 histone acetyltransferase activity relationship: linked_to NeXO:8785 ! CC: | BP: | MF: [Term] id: NeXO:5151 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.836907722 cc_score:0.0 bp_score:0.0 mf_score:0.0972591 relationship: child_of NeXO:5476 ! CC: | BP: | MF: [Term] id: NeXO:5150 name: CC: | BP: | MF:dipeptidyl-peptidase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.681981112 cc_score:0.0 bp_score:0.0 mf_score:0.231254 relationship: child_of NeXO:5154 ! CC: | BP: glutamate catabolic process | MF:glutamate decarboxylase activity [Term] id: NeXO:5153 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.871800902 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5413 ! CC: | BP: | MF: [Term] id: NeXO:5152 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88299573 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6431 ! CC: | BP: lipid translocation | MF:phospholipid transporter activity [Term] id: NeXO:5155 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.73933962 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5185 ! CC: | BP: | MF: [Term] id: NeXO:5154 name: CC: | BP: glutamate catabolic process | MF:glutamate decarboxylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. | MF_def:Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84350233 cc_score:0.0 bp_score:0.158456 mf_score:0.251841 relationship: child_of NeXO:5474 ! CC: | BP: | MF: [Term] id: NeXO:5157 name: CC: UDP-N-acetylglucosamine transferase complex | BP: | MF:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity def: "CC_def: A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis. | BP_def: | MF_def:Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [NeXO-GO:term] namespace: NeXO comment: robustness:4.16264101628344 density:1 bootstrap:0.95705324 cc_score:0.880435 bp_score:0.0520066 mf_score:0.583853 relationship: child_of NeXO:joining_root ! CC: cellular_component | BP: biological_process | MF:molecular_function [Term] id: NeXO:5156 name: CC: | BP: | MF:trans-hexaprenyltranstransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8493994 cc_score:0.0 bp_score:0.0 mf_score:0.313676 relationship: child_of NeXO:5405 ! CC: | BP: | MF: [Term] id: NeXO:7875 name: CC: | BP: glutamate catabolic process to 2-oxoglutarate | MF:glutamate-ammonia ligase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate. | MF_def:Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.16767303206347 density:1 bootstrap:0.77859103 cc_score:0.0 bp_score:0.444249 mf_score:0.44857 relationship: child_of NeXO:8486 ! CC: | BP: glutamine biosynthetic process | MF:glutamate dehydrogenase activity relationship: linked_to NeXO:7600 ! CC: | BP: | MF:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: NeXO:7876 name: CC: | BP: phospholipase C activity | MF:glycerophosphocholine phosphodiesterase activity def: "CC_def: | BP_def: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. | MF_def:Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.327483691 cc_score:0.0 bp_score:0.291667 mf_score:0.439869 relationship: child_of NeXO:8286 ! CC: | BP: glycerophospholipid catabolic process | MF:glycerophosphodiester phosphodiesterase activity [Term] id: NeXO:7877 name: CC: | BP: cellular manganese ion homeostasis | MF: def: "CC_def: | BP_def: Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.98917936281996 density:1 bootstrap:0.655646484 cc_score:0.0 bp_score:0.109692 mf_score:0.0 relationship: child_of NeXO:9267 ! CC: | BP: | MF: relationship: linked_to NeXO:9306 ! CC: | BP: | MF:mannosyl-oligosaccharide glucosidase activity relationship: linked_to NeXO:7305 ! CC: | BP: | MF:FAD transmembrane transporter activity relationship: linked_to NeXO:9170 ! CC: | BP: | MF: [Term] id: NeXO:7870 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.72510059 cc_score:0.0 bp_score:0.0233519 mf_score:0.0 relationship: child_of NeXO:8476 ! CC: | BP: | MF: relationship: linked_to NeXO:9317 ! CC: | BP: | MF: [Term] id: NeXO:7871 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.36464535501673 density:0.238095238095238 bootstrap:0.55804692 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8972 ! CC: | BP: | MF: [Term] id: NeXO:7872 name: CC: | BP: positive regulation of sodium ion transport | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.264983522 cc_score:0.0 bp_score:0.206502 mf_score:0.0 relationship: child_of NeXO:8389 ! CC: | BP: | MF: relationship: linked_to NeXO:9914 ! CC: | BP: regulation of tRNA export from nucleus | MF: [Term] id: NeXO:7873 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.6825650762616 density:0.4 bootstrap:0.382679809 cc_score:0.0 bp_score:0.0256621 mf_score:0.0 relationship: child_of NeXO:8338 ! CC: | BP: | MF: [Term] id: NeXO:5660 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80340812 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6104 ! CC: | BP: ethanol oxidation | MF:S-(hydroxymethyl)glutathione dehydrogenase activity [Term] id: NeXO:8398 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.60249494645378 density:1 bootstrap:0.71681146 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9010 ! CC: | BP: | MF: relationship: linked_to NeXO:8785 ! CC: | BP: | MF: [Term] id: NeXO:7336 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.33899665301509 density:0.2 bootstrap:0.455666366 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8049 ! CC: | BP: | MF: [Term] id: NeXO:7482 name: CC: nuclear RNA export factor complex | BP: | MF: def: "CC_def: A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78663196 cc_score:0.291859 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8382 ! CC: | BP: | MF:inositol hexakisphosphate binding relationship: linked_to NeXO:9087 ! CC: | BP: | MF: [Term] id: NeXO:8197 name: CC: | BP: | MF:phosphatidylinositol deacylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.383947861 cc_score:0.0 bp_score:0.0 mf_score:0.313697 relationship: child_of NeXO:9348 ! CC: | BP: | MF: relationship: linked_to NeXO:8583 ! CC: | BP: | MF: [Term] id: NeXO:8979 name: CC: | BP: ultradian rhythm | MF: def: "CC_def: | BP_def: The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.8734001943995 density:0.166666666666667 bootstrap:0.179521231 cc_score:0.0 bp_score:0.205608 mf_score:0.0877646 relationship: child_of NeXO:9588 ! CC: | BP: actin cortical patch assembly | MF: [Term] id: NeXO:9612 name: CC: | BP: GDP-mannose biosynthetic process | MF:mannose-1-phosphate guanylyltransferase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. | MF_def:Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [NeXO-GO:term] namespace: NeXO comment: robustness:3.79449817785868 density:0.380952380952381 bootstrap:0.399004596 cc_score:0.0 bp_score:0.126693 mf_score:0.152891 relationship: child_of NeXO:9807 ! CC: | BP: regulation of ER to Golgi vesicle-mediated transport | MF: [Term] id: NeXO:9464 name: CC: DNA-directed RNA polymerase III complex | BP: tRNA transcription from RNA polymerase III promoter | MF: def: "CC_def: RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. | BP_def: The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.104259997071 density:1 bootstrap:0.599231443 cc_score:0.512576 bp_score:0.527198 mf_score:0.0 relationship: child_of NeXO:9678 ! CC: DNA-directed RNA polymerase I complex | BP: | MF: [Term] id: NeXO:9467 name: CC: | BP: DNA replication, removal of RNA primer | MF: def: "CC_def: | BP_def: Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.54215308336933 density:0.466666666666667 bootstrap:0.437455071 cc_score:0.0 bp_score:0.168799 mf_score:0.0 relationship: child_of NeXO:9717 ! CC: | BP: lagging strand elongation | MF: relationship: linked_to NeXO:9699 ! CC: | BP: negative regulation of DNA-dependent DNA replication | MF: [Term] id: NeXO:9466 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.11089447165623 density:0.0952380952380952 bootstrap:0.182740049 cc_score:0.0 bp_score:0.0732865 mf_score:0.0 relationship: child_of NeXO:9777 ! CC: Sin3-type complex | BP: regulation of chromatin silencing at rDNA | MF: [Term] id: NeXO:6309 name: CC: | BP: mitotic cell cycle DNA replication checkpoint | MF:dCMP deaminase activity def: "CC_def: | BP_def: A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. | MF_def:Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.682112652 cc_score:0.0 bp_score:0.440448 mf_score:0.439666 relationship: child_of NeXO:7359 ! CC: | BP: DNA replication preinitiation complex assembly | MF: [Term] id: NeXO:6308 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.07190075628373 density:1 bootstrap:0.71131136 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6721 ! CC: signal recognition particle receptor complex | BP: receptor activity | MF:signal recognition particle binding relationship: linked_to NeXO:7819 ! CC: | BP: phosphatidylserine biosynthetic process | MF:phosphatidylethanolamine N-methyltransferase activity [Term] id: NeXO:9463 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.4375938975546 density:0.428571428571429 bootstrap:0.356568662 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9557 ! CC: | BP: | MF: [Term] id: NeXO:9462 name: CC: | BP: tRNA wobble uridine modification | MF: def: "CC_def: | BP_def: The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:19.5384531257385 density:0.75 bootstrap:0.79805009 cc_score:0.0 bp_score:0.311913 mf_score:0.0505698 relationship: child_of NeXO:9537 ! CC: | BP: tRNA thio-modification | MF: [Term] id: NeXO:6305 name: CC: | BP: positive regulation of transcription from RNA polymerase II promoter in response to iron | MF:sulfate adenylyltransferase (ADP) activity def: "CC_def: | BP_def: Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. | MF_def:Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.542403973 cc_score:0.0 bp_score:0.443749 mf_score:0.449006 relationship: child_of NeXO:6967 ! CC: | BP: | MF:dolichol kinase activity relationship: linked_to NeXO:6968 ! CC: | BP: | MF:polynucleotide 3'-phosphatase activity [Term] id: NeXO:6304 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.00403060490114 density:0.0666666666666667 bootstrap:0.30148722 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6791 ! CC: | BP: | MF:transferase activity, transferring aldehyde or ketonic groups [Term] id: NeXO:6307 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.5992475894488 density:1 bootstrap:0.42379249 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7311 ! CC: | BP: | MF: relationship: linked_to NeXO:6378 ! CC: | BP: | MF: relationship: linked_to NeXO:6929 ! CC: | BP: | MF: relationship: linked_to NeXO:8994 ! CC: | BP: | MF: [Term] id: NeXO:6419 name: CC: | BP: polyamine biosynthetic process | MF:spermidine synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. | MF_def:Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [NeXO-GO:term] namespace: NeXO comment: robustness:4.64232676659642 density:0.5 bootstrap:0.87407706 cc_score:0.0 bp_score:0.401294 mf_score:0.214538 relationship: child_of NeXO:7087 ! CC: | BP: polyamine metabolic process | MF: [Term] id: NeXO:9469 name: CC: | BP: postreplication repair | MF: def: "CC_def: | BP_def: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.68288396211924 density:0.238095238095238 bootstrap:0.139604838 cc_score:0.0 bp_score:0.119669 mf_score:0.0 relationship: child_of NeXO:9717 ! CC: | BP: lagging strand elongation | MF: [Term] id: NeXO:6300 name: CC: | BP: negative regulation of ATPase activity | MF:copper uptake transmembrane transporter activity def: "CC_def: | BP_def: Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.76132332 cc_score:0.0 bp_score:0.221344 mf_score:0.22541 relationship: child_of NeXO:6301 ! CC: | BP: | MF: [Term] id: NeXO:6303 name: CC: acetolactate synthase complex | BP: | MF:acetolactate synthase activity def: "CC_def: A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. | BP_def: | MF_def:Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.48171506 cc_score:0.291754 bp_score:0.0 mf_score:0.30061 relationship: child_of NeXO:6791 ! CC: | BP: | MF:transferase activity, transferring aldehyde or ketonic groups relationship: linked_to NeXO:6302 ! CC: | BP: | MF:organic anion transmembrane transporter activity [Term] id: NeXO:6302 name: CC: | BP: | MF:organic anion transmembrane transporter activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [NeXO-GO:term] namespace: NeXO comment: robustness:1.51287230633776 density:0.1 bootstrap:0.611452986 cc_score:0.0 bp_score:0.0674097 mf_score:0.142967 relationship: child_of NeXO:6304 ! CC: | BP: | MF: [Term] id: NeXO:9089 name: CC: | BP: telomere tethering at nuclear periphery | MF:nuclear localization sequence binding def: "CC_def: | BP_def: The process in which a telomere is maintained in a specific location at the nuclear periphery. | MF_def:Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.45629165 cc_score:0.0 bp_score:0.150599 mf_score:0.220343 relationship: child_of NeXO:9551 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:9671 ! CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: relationship: linked_to NeXO:9430 ! CC: | BP: | MF:Ran GTPase activator activity [Term] id: NeXO:9087 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.62673933799674 density:0.333333333333333 bootstrap:0.535815167 cc_score:0.0 bp_score:0.0202365 mf_score:0.0 relationship: child_of NeXO:9671 ! CC: | BP: nuclear retention of pre-mRNA at the site of transcription | MF: relationship: linked_to NeXO:9520 ! CC: | BP: | MF: relationship: linked_to NeXO:8549 ! CC: | BP: poly(A)+ mRNA export from nucleus | MF: [Term] id: NeXO:9086 name: CC: transcription export complex | BP: | MF: def: "CC_def: The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.34126423606044 density:1 bootstrap:0.76855943 cc_score:0.504424 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9493 ! CC: nucleoplasmic THO complex | BP: | MF: [Term] id: NeXO:9085 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.87357187950665 density:0.0504032258064516 bootstrap:0.148988821 cc_score:0.0 bp_score:0.024882 mf_score:0.0 relationship: child_of NeXO:9648 ! CC: | BP: | MF: [Term] id: NeXO:9084 name: CC: | BP: regulation of histone H3-K36 methylation | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.95883037208844 density:0.333333333333333 bootstrap:0.409570392 cc_score:0.0 bp_score:0.161404 mf_score:0.0 relationship: child_of NeXO:9890 ! CC: preribosome, large subunit precursor | BP: ribosomal large subunit biogenesis | MF: [Term] id: NeXO:9083 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.08918192731739 density:0.2 bootstrap:0.527379919 cc_score:0.0 bp_score:0.0230589 mf_score:0.0 relationship: child_of NeXO:9769 ! CC: | BP: ribosomal large subunit assembly | MF: relationship: linked_to NeXO:9295 ! CC: | BP: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF:LSU rRNA binding [Term] id: NeXO:9081 name: CC: | BP: | MF:mRNA 3'-UTR binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:2.0024134385083 density:1 bootstrap:0.66439958 cc_score:0.0 bp_score:0.0 mf_score:0.438222 relationship: child_of NeXO:9534 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: relationship: linked_to NeXO:9504 ! CC: Noc complex | BP: | MF: relationship: linked_to NeXO:8667 ! CC: | BP: | MF: [Term] id: NeXO:9080 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.19084764730544 density:0.666666666666667 bootstrap:0.437418649 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9422 ! CC: Golgi stack | BP: | MF: relationship: linked_to NeXO:7971 ! CC: | BP: | MF: relationship: linked_to NeXO:7164 ! CC: | BP: | MF: [Term] id: NeXO:6248 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.80984658 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6249 ! CC: | BP: | MF: [Term] id: NeXO:9649 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.24692610672959 density:0.0370027752081406 bootstrap:0.139671669 cc_score:0.0 bp_score:0.0463037 mf_score:0.0181055 relationship: child_of NeXO:9877 ! CC: | BP: | MF: [Term] id: NeXO:9648 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.12509711365309 density:0.0421422300263389 bootstrap:0.19756091 cc_score:0.0 bp_score:0.0159653 mf_score:0.033122 relationship: child_of NeXO:9814 ! CC: | BP: | MF: [Term] id: NeXO:8057 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.303621643 cc_score:0.0 bp_score:0.0123146 mf_score:0.0106452 relationship: child_of NeXO:8993 ! CC: | BP: nuclear polyadenylation-dependent snoRNA catabolic process | MF:adenylyltransferase activity [Term] id: NeXO:9318 name: CC: | BP: 'de novo' protein folding | MF: def: "CC_def: | BP_def: The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.642897228 cc_score:0.0 bp_score:0.156243 mf_score:0.0 relationship: child_of NeXO:9631 ! CC: | BP: | MF: relationship: linked_to NeXO:9955 ! CC: | BP: protein import into nucleus, translocation | MF: [Term] id: NeXO:9645 name: CC: peroxisomal part | BP: peroxisome organization | MF: def: "CC_def: Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:12.0634245835879 density:0.088647670737223 bootstrap:0.274670796 cc_score:0.225804 bp_score:0.166846 mf_score:0.0 relationship: child_of NeXO:9872 ! CC: peroxisome | BP: | MF: [Term] id: NeXO:9644 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.47293301940567 density:0.210526315789474 bootstrap:0.38082849 cc_score:0.0 bp_score:0.0899417 mf_score:0.0192505 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: [Term] id: NeXO:9647 name: CC: 90S preribosome | BP: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: def: "CC_def: A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. | BP_def: Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.0891669894289 density:0.0995670995670996 bootstrap:0.387402507 cc_score:0.108219 bp_score:0.124572 mf_score:0.0221118 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: [Term] id: NeXO:9646 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.00732260263532 density:0.0220408163265306 bootstrap:0.104454679 cc_score:0.0 bp_score:0.029509 mf_score:0.0340374 relationship: child_of NeXO:9860 ! CC: | BP: | MF: [Term] id: NeXO:9312 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.09823705146821 density:0.9 bootstrap:0.71494493 cc_score:0.0 bp_score:0.0126636 mf_score:0.0 relationship: child_of NeXO:9630 ! CC: Swr1 complex | BP: histone exchange | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation [Term] id: NeXO:9643 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.43573606878608 density:0.177777777777778 bootstrap:0.20337999 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9949 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:9310 name: CC: exocyst | BP: vesicle docking involved in exocytosis | MF: def: "CC_def: A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. | BP_def: The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.83681516755787 density:0.777777777777778 bootstrap:0.514469183 cc_score:0.677119 bp_score:0.320195 mf_score:0.0 relationship: child_of NeXO:9662 ! CC: | BP: vesicle docking | MF: [Term] id: NeXO:8307 name: CC: | BP: | MF:methionine adenosyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.304527748 cc_score:0.0 bp_score:0.082081 mf_score:0.201658 relationship: child_of NeXO:9219 ! CC: | BP: | MF: relationship: linked_to NeXO:9443 ! CC: | BP: | MF:3-phosphoshikimate 1-carboxyvinyltransferase activity relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7273 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.579418268 cc_score:0.0 bp_score:0.0301834 mf_score:0.0 relationship: child_of NeXO:8057 ! CC: | BP: | MF: [Term] id: NeXO:7270 name: CC: Dbf4-dependent protein kinase complex | BP: | MF:protein serine/threonine kinase activator activity def: "CC_def: A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. | BP_def: | MF_def:Increases the activity of a protein serine/threonine kinase." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8384114 cc_score:0.291793 bp_score:0.0799717 mf_score:0.296253 relationship: child_of NeXO:8532 ! CC: | BP: regulation of DNA-dependent DNA replication initiation | MF:protein kinase activator activity relationship: linked_to NeXO:8969 ! CC: | BP: | MF: relationship: linked_to NeXO:9214 ! CC: | BP: | MF: [Term] id: NeXO:7271 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.71854592 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7650 ! CC: | BP: cellular response to anoxia | MF: [Term] id: NeXO:8790 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.45829750656686 density:0.142857142857143 bootstrap:0.194310398 cc_score:0.0 bp_score:0.0112652 mf_score:0.0 relationship: child_of NeXO:9273 ! CC: | BP: | MF: [Term] id: NeXO:8953 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.06398165885914 density:0.166666666666667 bootstrap:0.2664143 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9515 ! CC: | BP: | MF: [Term] id: NeXO:7274 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.406620203 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8545 ! CC: | BP: | MF:sterol-transporting ATPase activity [Term] id: NeXO:7275 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58180234 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7813 ! CC: | BP: | MF: [Term] id: NeXO:5083 name: CC: mating projection membrane | BP: negative regulation of protein phosphorylation | MF: def: "CC_def: The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone. | BP_def: Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.893872828 cc_score:0.298743 bp_score:0.44289 mf_score:0.0 relationship: child_of NeXO:5383 ! CC: | BP: negative regulation of phosphate metabolic process | MF: [Term] id: NeXO:5081 name: CC: | BP: | MF:5'-tyrosyl-DNA phosphodiesterase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.64930809 cc_score:0.0 bp_score:0.0 mf_score:0.4375 relationship: child_of NeXO:5109 ! CC: | BP: meiotic gene conversion | MF:3'-tyrosyl-DNA phosphodiesterase activity [Term] id: NeXO:7279 name: CC: | BP: alpha-glucoside transport | MF:alpha-glucoside:hydrogen symporter activity def: "CC_def: | BP_def: The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. | MF_def:Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.352810769 cc_score:0.0 bp_score:0.144092 mf_score:0.179378 relationship: child_of NeXO:8105 ! CC: | BP: | MF:acireductone dioxygenase (Ni2+-requiring) activity relationship: linked_to NeXO:8259 ! CC: | BP: | MF: relationship: linked_to NeXO:7349 ! CC: | BP: | MF: [Term] id: NeXO:5087 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.763102921 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5110 ! CC: | BP: | MF: [Term] id: NeXO:5086 name: CC: | BP: response to ethanol | MF:pyridoxamine-phosphate oxidase activity def: "CC_def: | BP_def: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. | MF_def:Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.888397418 cc_score:0.0 bp_score:0.156914 mf_score:0.222152 relationship: child_of NeXO:5087 ! CC: | BP: | MF: [Term] id: NeXO:5085 name: CC: | BP: | MF:single-stranded DNA specific endodeoxyribonuclease activity def: "CC_def: | BP_def: | MF_def:Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81069961 cc_score:0.0 bp_score:0.0 mf_score:0.111464 relationship: child_of NeXO:5155 ! CC: | BP: | MF: [Term] id: NeXO:5084 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.93950615 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5207 ! CC: | BP: | MF: [Term] id: NeXO:9793 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:9.9850085255039 density:0.977777777777778 bootstrap:0.380873202 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9904 ! CC: | BP: | MF: relationship: linked_to NeXO:9817 ! CC: | BP: | MF: relationship: linked_to NeXO:9670 ! CC: | BP: | MF: relationship: linked_to NeXO:9787 ! CC: | BP: | MF: [Term] id: NeXO:9792 name: CC: | BP: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | MF:phosphoprotein binding def: "CC_def: | BP_def: A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. | MF_def:Interacting selectively and non-covalently with a phosphorylated protein." [NeXO-GO:term] namespace: NeXO comment: robustness:1.98644415263695 density:0.4 bootstrap:0.209839738 cc_score:0.0 bp_score:0.31789 mf_score:0.286593 relationship: child_of NeXO:9897 ! CC: | BP: regulation of ubiquitin-protein ligase activity | MF:amino acid binding relationship: linked_to NeXO:8288 ! CC: | BP: extrachromosomal rDNA circle accumulation involved in replicative cell aging | MF:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [Term] id: NeXO:9791 name: CC: | BP: signal transduction involved in filamentous growth | MF:receptor signaling protein serine/threonine kinase activity def: "CC_def: | BP_def: Relaying of environmental signals promoting filamentous growth. | MF_def:Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:10.4556890779333 density:0.666666666666667 bootstrap:0.483980251 cc_score:0.0367987 bp_score:0.226924 mf_score:0.164664 relationship: child_of NeXO:9896 ! CC: | BP: pheromone-dependent signal transduction involved in conjugation with cellular fusion | MF:receptor signaling protein activity [Term] id: NeXO:5736 name: CC: | BP: ribonucleoside catabolic process | MF:nicotinamide riboside hydrolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. | MF_def:Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.658421893 cc_score:0.0 bp_score:0.117265 mf_score:0.137738 relationship: child_of NeXO:6783 ! CC: | BP: GO:0035965 | MF: [Term] id: NeXO:5896 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.31732653433408 density:1 bootstrap:0.88980802 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8144 ! CC: | BP: mitochondrial tRNA modification | MF: [Term] id: NeXO:9796 name: CC: | BP: protein N-linked glycosylation | MF:transferase activity, transferring hexosyl groups def: "CC_def: | BP_def: A protein glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. | MF_def:Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [NeXO-GO:term] namespace: NeXO comment: robustness:19.6931793149305 density:0.465465465465465 bootstrap:0.528899 cc_score:0.0584534 bp_score:0.157139 mf_score:0.103849 relationship: child_of NeXO:9961 ! CC: endoplasmic reticulum part | BP: glycosylation | MF: [Term] id: NeXO:9795 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.5317854095501 density:0.344827586206897 bootstrap:0.359444295 cc_score:0.0 bp_score:0.0476807 mf_score:0.0 relationship: child_of NeXO:9796 ! CC: | BP: protein N-linked glycosylation | MF:transferase activity, transferring hexosyl groups [Term] id: NeXO:9794 name: CC: | BP: protein localization in endoplasmic reticulum | MF: def: "CC_def: | BP_def: A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.33216205414961 density:0.123188405797101 bootstrap:0.178096106 cc_score:0.0331985 bp_score:0.125648 mf_score:0.0 relationship: child_of NeXO:9961 ! CC: endoplasmic reticulum part | BP: glycosylation | MF: [Term] id: NeXO:8008 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.85430260840178 density:0.666666666666667 bootstrap:0.742459842 cc_score:0.0 bp_score:0.0232107 mf_score:0.0 relationship: child_of NeXO:9151 ! CC: | BP: mitotic chromosome condensation | MF: relationship: linked_to NeXO:9152 ! CC: nuclear mitotic cohesin complex | BP: protein localization to chromatin | MF: [Term] id: NeXO:9799 name: CC: RNA cap binding complex | BP: | MF: def: "CC_def: Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1522645150125 density:0.714285714285714 bootstrap:0.333320484 cc_score:0.186173 bp_score:0.0180436 mf_score:0.0 relationship: child_of NeXO:9833 ! CC: | BP: | MF: relationship: linked_to NeXO:9179 ! CC: | BP: | MF: [Term] id: NeXO:9798 name: CC: mitochondrial inner membrane | BP: | MF: def: "CC_def: The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:10.808035704872 density:0.0536949685534591 bootstrap:0.159306911 cc_score:0.165142 bp_score:0.0837464 mf_score:0.0917282 relationship: child_of NeXO:9958 ! CC: mitochondrial membrane part | BP: mitochondrion organization | MF: [Term] id: NeXO:9302 name: CC: chromatin assembly complex | BP: DNA replication-independent nucleosome organization | MF: def: "CC_def: Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure. | BP_def: The formation or destruction of chromatin structures, occurring outside the context of DNA replication. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.26887659932435 density:1 bootstrap:0.85298933 cc_score:0.176469 bp_score:0.173416 mf_score:0.0 relationship: child_of NeXO:9868 ! CC: chromatin silencing complex | BP: progressive alteration of chromatin involved in cell aging | MF:nucleosome binding relationship: linked_to NeXO:10000 ! CC: | BP: | MF: relationship: linked_to NeXO:9830 ! CC: nuclear nucleosome | BP: nucleosome assembly | MF:histone H3-K79 methylation relationship: linked_to NeXO:8152 ! CC: Cul8-RING ubiquitin ligase complex | BP: replication fork processing | MF:H3 histone acetyltransferase activity relationship: linked_to NeXO:8660 ! CC: | BP: | MF: relationship: linked_to NeXO:7833 ! CC: HIR complex | BP: DNA replication-independent nucleosome assembly | MF: [Term] id: NeXO:8009 name: CC: pre-autophagosomal structure membrane | BP: protein homooligomerization | MF: def: "CC_def: A cellular membrane associated with the pre-autophagosomal structure. | BP_def: The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2515078800244 density:0.666666666666667 bootstrap:0.461976498 cc_score:0.213188 bp_score:0.114846 mf_score:0.0 relationship: child_of NeXO:8253 ! CC: | BP: mitochondrion degradation | MF:APG8 activating enzyme activity [Term] id: NeXO:6833 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.51704596758586 density:0.0454545454545455 bootstrap:0.307401066 cc_score:0.0 bp_score:0.052157 mf_score:0.0 relationship: child_of NeXO:7328 ! CC: | BP: | MF: [Term] id: NeXO:6832 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.82970857132218 density:0.666666666666667 bootstrap:0.68420627 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8378 ! CC: | BP: | MF: [Term] id: NeXO:8791 name: CC: | BP: mitotic cell cycle spindle orientation checkpoint | MF: def: "CC_def: | BP_def: A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.92320226772066 density:1 bootstrap:0.61287481 cc_score:0.0 bp_score:0.299385 mf_score:0.0 relationship: child_of NeXO:9432 ! CC: | BP: mitotic cell cycle spindle checkpoint | MF: relationship: linked_to NeXO:8530 ! CC: | BP: plus-end specific microtubule depolymerization | MF:tubulin-dependent ATPase activity relationship: linked_to NeXO:7321 ! CC: cytoplasmic dynein complex | BP: microtubule motor activity | MF:microtubule motor activity [Term] id: NeXO:6830 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.26144066033235 density:0.0666666666666667 bootstrap:0.475892276 cc_score:0.0 bp_score:0.0 mf_score:0.0995183 relationship: child_of NeXO:7803 ! CC: | BP: | MF: [Term] id: NeXO:6837 name: CC: | BP: potassium ion transmembrane transport | MF:potassium ion transmembrane transporter activity def: "CC_def: | BP_def: A process in which a potassium ion is transported from one side of a membrane to the other. | MF_def:Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other." [NeXO-GO:term] namespace: NeXO comment: robustness:2.41827501268145 density:0.5 bootstrap:0.386909281 cc_score:0.0 bp_score:0.395144 mf_score:0.201416 relationship: child_of NeXO:7052 ! CC: | BP: | MF: [Term] id: NeXO:6836 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.4007661153443 density:0.190476190476190 bootstrap:0.747309576 cc_score:0.0 bp_score:0.056344 mf_score:0.0 relationship: child_of NeXO:8209 ! CC: | BP: | MF: [Term] id: NeXO:6835 name: CC: | BP: | MF:adenylylsulfate kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [NeXO-GO:term] namespace: NeXO comment: robustness:1.7999446371506 density:0.333333333333333 bootstrap:0.655990212 cc_score:0.0 bp_score:0.0 mf_score:0.312664 relationship: child_of NeXO:6858 ! CC: | BP: methionine biosynthetic process | MF:uroporphyrin-III C-methyltransferase activity [Term] id: NeXO:6834 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16032055815639 density:0.2 bootstrap:0.563906974 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7212 ! CC: | BP: fatty acid catabolic process | MF: [Term] id: NeXO:6839 name: CC: | BP: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09083076031621 density:1 bootstrap:0.724368587 cc_score:0.0 bp_score:0.11337 mf_score:0.0 relationship: child_of NeXO:8241 ! CC: cytoplasmic exosome (RNase complex) | BP: nonfunctional rRNA decay | MF: relationship: linked_to NeXO:9317 ! CC: | BP: | MF: relationship: linked_to NeXO:6228 ! CC: | BP: polyadenylation-dependent snoRNA 3'-end processing | MF: [Term] id: NeXO:6838 name: CC: fungal-type vacuole lumen | BP: | MF:metallocarboxypeptidase activity def: "CC_def: The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae. | BP_def: | MF_def:Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.626612304 cc_score:0.207983 bp_score:0.0 mf_score:0.23362 relationship: child_of NeXO:7489 ! CC: vacuolar lumen | BP: positive regulation of ubiquitin-dependent endocytosis | MF: [Term] id: NeXO:6895 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.47731257 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7144 ! CC: | BP: | MF: [Term] id: NeXO:5664 name: CC: | BP: | MF:calcium-dependent phospholipid binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.417275236 cc_score:0.0 bp_score:0.0 mf_score:0.292337 relationship: child_of NeXO:5736 ! CC: | BP: ribonucleoside catabolic process | MF:nicotinamide riboside hydrolase activity relationship: linked_to NeXO:10019 ! CC: | BP: | MF:protein tag [Term] id: NeXO:5330 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84484331 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6682 ! CC: | BP: | MF: [Term] id: NeXO:5333 name: CC: | BP: | MF:translation release factor activity def: "CC_def: | BP_def: | MF_def:Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84040119 cc_score:0.0 bp_score:0.0 mf_score:0.124903 relationship: child_of NeXO:6019 ! CC: | BP: | MF:2-isopropylmalate synthase activity [Term] id: NeXO:6856 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.67109213 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7882 ! CC: | BP: | MF: relationship: linked_to NeXO:9342 ! CC: | BP: negative regulation of transcription factor import into nucleus | MF: [Term] id: NeXO:5335 name: CC: | BP: plasma membrane organization | MF: def: "CC_def: | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78309576 cc_score:0.0 bp_score:0.156752 mf_score:0.0 relationship: child_of NeXO:6463 ! CC: | BP: | MF: [Term] id: NeXO:5334 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.94978708 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5986 ! CC: | BP: | MF: [Term] id: NeXO:5337 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85207376 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6729 ! CC: | BP: | MF: [Term] id: NeXO:5336 name: CC: | BP: transcription initiation from mitochondrial promoter | MF:mitochondrial RNA polymerase binding promoter specificity activity def: "CC_def: | BP_def: A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase. | MF_def:Interacting selectively and non-covalently with a mitochondrial RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of mitochondrial promoter DNA sequence motifs." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87174219 cc_score:0.0 bp_score:0.45832 mf_score:0.43921 relationship: child_of NeXO:5455 ! CC: mitochondrial DNA-directed RNA polymerase complex | BP: transcription from mitochondrial promoter | MF:transcription from mitochondrial promoter [Term] id: NeXO:5339 name: CC: | BP: seryl-tRNA aminoacylation | MF:serine-tRNA ligase activity def: "CC_def: | BP_def: The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | MF_def:Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85704254 cc_score:0.0 bp_score:0.282815 mf_score:0.292758 relationship: child_of NeXO:5992 ! CC: | BP: | MF: [Term] id: NeXO:9981 name: CC: endosome | BP: vesicle-mediated transport | MF:protein transport def: "CC_def: A membrane-bounded organelle to which materials ingested by endocytosis are delivered. | BP_def: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. | MF_def:The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [NeXO-GO:term] namespace: NeXO comment: robustness:15.265310638097 density:0.0328426766885896 bootstrap:0.317798884 cc_score:0.10164 bp_score:0.204916 mf_score:0.171084 relationship: child_of NeXO:9997 ! CC: | BP: protein localization | MF:transport [Term] id: NeXO:9140 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.09837240399343 density:0.0428571428571429 bootstrap:0.224647727 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9649 ! CC: | BP: | MF: [Term] id: NeXO:6470 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.697101928 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7580 ! CC: | BP: | MF: [Term] id: NeXO:7353 name: CC: | BP: dTTP biosynthetic process | MF:thymidylate kinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. | MF_def:Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.58609764 cc_score:0.0 bp_score:0.441145 mf_score:0.440504 relationship: child_of NeXO:8230 ! CC: | BP: dTDP biosynthetic process | MF:uridylate kinase activity relationship: linked_to NeXO:9428 ! CC: | BP: DNA replication checkpoint | MF: [Term] id: NeXO:9200 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.71084876744706 density:0.4 bootstrap:0.390791938 cc_score:0.0869562 bp_score:0.0694959 mf_score:0.0671223 relationship: child_of NeXO:9654 ! CC: | BP: | MF: [Term] id: NeXO:9410 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.4905733962108 density:0.0588235294117647 bootstrap:0.276992815 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9637 ! CC: | BP: | MF: [Term] id: NeXO:8416 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.75742803 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9321 ! CC: | BP: | MF: relationship: linked_to NeXO:8983 ! CC: | BP: | MF: [Term] id: NeXO:8822 name: CC: | BP: | MF:pseudouridylate synthase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.530583323 cc_score:0.0 bp_score:0.0268472 mf_score:0.439239 relationship: child_of NeXO:9327 ! CC: | BP: positive regulation of lipid biosynthetic process | MF: relationship: linked_to NeXO:9409 ! CC: | BP: | MF: relationship: linked_to NeXO:9230 ! CC: | BP: | MF: [Term] id: NeXO:8823 name: CC: internal side of plasma membrane | BP: regulation of cAMP biosynthetic process | MF: def: "CC_def: The side of the plasma membrane that faces the cytoplasm. | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.40656198254066 density:0.142857142857143 bootstrap:0.138746286 cc_score:0.104094 bp_score:0.218617 mf_score:0.0 relationship: child_of NeXO:9529 ! CC: | BP: cAMP biosynthetic process | MF: [Term] id: NeXO:8820 name: CC: | BP: mitochondrial respiratory chain complex IV biogenesis | MF: def: "CC_def: | BP_def: The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.02083040063792 density:0.123809523809524 bootstrap:0.310465549 cc_score:0.0 bp_score:0.179725 mf_score:0.0 relationship: child_of NeXO:9452 ! CC: | BP: purine ribonucleoside triphosphate biosynthetic process | MF:hydrogen ion transmembrane transporter activity [Term] id: NeXO:8826 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.37399696840709 density:0.163636363636364 bootstrap:0.357506297 cc_score:0.0 bp_score:0.0673879 mf_score:0.0 relationship: child_of NeXO:9441 ! CC: | BP: | MF: [Term] id: NeXO:8827 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.62566764470083 density:0.5 bootstrap:0.533155988 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9417 ! CC: | BP: | MF: relationship: linked_to NeXO:9604 ! CC: | BP: | MF: [Term] id: NeXO:8825 name: CC: septin filament array | BP: maintenance of cell polarity | MF:1-phosphatidylinositol binding def: "CC_def: Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. | BP_def: The maintenance of established anisotropic intracellular organization or cell growth patterns. | MF_def:Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [NeXO-GO:term] namespace: NeXO comment: robustness:7.15394503466363 density:1 bootstrap:0.84801237 cc_score:0.711619 bp_score:0.251671 mf_score:0.321164 relationship: child_of NeXO:9614 ! CC: septin complex | BP: septin ring assembly | MF: [Term] id: NeXO:7097 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.8259048915383 density:0.333333333333333 bootstrap:0.67504911 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8167 ! CC: | BP: | MF:nucleosomal histone binding [Term] id: NeXO:8828 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.5183696480489 density:0.0606060606060606 bootstrap:0.214046655 cc_score:0.0 bp_score:0.0129072 mf_score:0.0 relationship: child_of NeXO:9262 ! CC: | BP: | MF: [Term] id: NeXO:8829 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.47537482976713 density:0.0392156862745098 bootstrap:0.167346858 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9547 ! CC: | BP: | MF: [Term] id: NeXO:9445 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.14830439845451 density:0.428571428571429 bootstrap:0.311594149 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9606 ! CC: | BP: | MF: [Term] id: NeXO:8778 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.63586489449743 density:0.333333333333333 bootstrap:0.74161958 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9353 ! CC: | BP: | MF: relationship: linked_to NeXO:9780 ! CC: | BP: | MF: [Term] id: NeXO:8779 name: CC: | BP: | MF:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [NeXO-GO:term] namespace: NeXO comment: robustness:2.12714818427319 density:1 bootstrap:0.74975149 cc_score:0.0 bp_score:0.0 mf_score:0.438223 relationship: child_of NeXO:9257 ! CC: | BP: | MF: relationship: linked_to NeXO:9112 ! CC: tight junction | BP: | MF: [Term] id: NeXO:6469 name: CC: | BP: | MF:oxidized purine base lesion DNA N-glycosylase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [NeXO-GO:term] namespace: NeXO comment: robustness:3.87768197513066 density:1 bootstrap:0.830505581 cc_score:0.0 bp_score:0.0 mf_score:0.250895 relationship: child_of NeXO:6806 ! CC: | BP: base-excision repair, AP site formation | MF:oxidized base lesion DNA N-glycosylase activity [Term] id: NeXO:8773 name: CC: SBF transcription complex | BP: UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response | MF: def: "CC_def: A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p. | BP_def: The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.323257224 cc_score:0.175716 bp_score:0.14741 mf_score:0.0 relationship: child_of NeXO:9100 ! CC: | BP: regulation of transcription involved in G1/S phase of mitotic cell cycle | MF: relationship: linked_to NeXO:9111 ! CC: | BP: positive regulation of transcription from RNA polymerase III promoter | MF: [Term] id: NeXO:8770 name: CC: alpha-1,6-mannosyltransferase complex | BP: substituted mannan metabolic process | MF: def: "CC_def: A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. | BP_def: The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.73901341953622 density:1 bootstrap:0.77216876 cc_score:0.444042 bp_score:0.220338 mf_score:0.0 relationship: child_of NeXO:9422 ! CC: Golgi stack | BP: | MF: [Term] id: NeXO:8776 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.3632110924447 density:0.1 bootstrap:0.496460553 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9215 ! CC: | BP: | MF: relationship: linked_to NeXO:9711 ! CC: actin filament | BP: negative regulation of actin filament polymerization | MF: [Term] id: NeXO:8777 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.4506538578978 density:1 bootstrap:0.65765931 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9232 ! CC: | BP: | MF: relationship: linked_to NeXO:9519 ! CC: | BP: | MF: relationship: linked_to NeXO:9538 ! CC: | BP: | MF: [Term] id: NeXO:8774 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.7226666330758 density:1 bootstrap:0.76543175 cc_score:0.0 bp_score:0.0361572 mf_score:0.0 relationship: child_of NeXO:9583 ! CC: | BP: polyol transport | MF: [Term] id: NeXO:8775 name: CC: | BP: | MF:phosphatidyl-N-dimethylethanolamine N-methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [NeXO-GO:term] namespace: NeXO comment: robustness:6.79112089839457 density:0.666666666666667 bootstrap:0.633114855 cc_score:0.0 bp_score:0.098766 mf_score:0.115068 relationship: child_of NeXO:9583 ! CC: | BP: polyol transport | MF: [Term] id: NeXO:7642 name: CC: | BP: putrescine biosynthetic process | MF:ornithine decarboxylase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. | MF_def:Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.63888999 cc_score:0.0 bp_score:0.443471 mf_score:0.294228 relationship: child_of NeXO:8282 ! CC: transcription factor TFIIE complex | BP: | MF: relationship: linked_to NeXO:6419 ! CC: | BP: polyamine biosynthetic process | MF:spermidine synthase activity [Term] id: NeXO:7641 name: CC: | BP: positive regulation of fatty acid metabolic process | MF:catalase activity def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. | MF_def:Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [NeXO-GO:term] namespace: NeXO comment: robustness:1.70192952302869 density:0.333333333333333 bootstrap:0.586492157 cc_score:0.0 bp_score:0.326355 mf_score:0.231896 relationship: child_of NeXO:8730 ! CC: | BP: positive regulation of lipid catabolic process | MF: [Term] id: NeXO:7647 name: CC: | BP: meiotic joint molecule formation | MF: def: "CC_def: | BP_def: The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.27280163162144 density:0.333333333333333 bootstrap:0.82282518 cc_score:0.0 bp_score:0.110014 mf_score:0.0894114 relationship: child_of NeXO:7648 ! CC: | BP: | MF: [Term] id: NeXO:7646 name: CC: | BP: peptidyl-histidine modification | MF: def: "CC_def: | BP_def: The modification of peptidyl-histidine. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.1200716584314 density:0.266666666666667 bootstrap:0.541488973 cc_score:0.0 bp_score:0.231051 mf_score:0.0 relationship: child_of NeXO:8843 ! CC: | BP: | MF: [Term] id: NeXO:7645 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.8411514304223 density:0.333333333333333 bootstrap:0.68636967 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8460 ! CC: | BP: | MF: [Term] id: NeXO:7644 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.527040843 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8250 ! CC: U2-type post-spliceosomal complex | BP: | MF: [Term] id: NeXO:6543 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.30638328979477 density:1 bootstrap:0.88142388 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7502 ! CC: Golgi cisterna | BP: regulation of ARF protein signal transduction | MF: relationship: linked_to NeXO:9129 ! CC: clathrin coat | BP: | MF: [Term] id: NeXO:7649 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.300387388 cc_score:0.0 bp_score:0.0380369 mf_score:0.0 relationship: child_of NeXO:8634 ! CC: | BP: | MF: relationship: linked_to NeXO:10000 ! CC: | BP: | MF: [Term] id: NeXO:7648 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.20240868028422 density:0.178571428571429 bootstrap:0.547665449 cc_score:0.0 bp_score:0.0 mf_score:0.065159 relationship: child_of NeXO:8423 ! CC: | BP: | MF: [Term] id: NeXO:8794 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.89587320841558 density:1 bootstrap:0.595580439 cc_score:0.0 bp_score:0.0209477 mf_score:0.0 relationship: child_of NeXO:9310 ! CC: exocyst | BP: vesicle docking involved in exocytosis | MF: relationship: linked_to NeXO:8298 ! CC: COPII vesicle coat | BP: regulation of COPII vesicle coating | MF: relationship: linked_to NeXO:7559 ! CC: | BP: | MF: relationship: linked_to NeXO:8760 ! CC: endoplasmic reticulum Sec complex | BP: posttranslational protein targeting to membrane, translocation | MF:P-P-bond-hydrolysis-driven protein transmembrane transporter activity relationship: linked_to NeXO:7488 ! CC: | BP: | MF: [Term] id: NeXO:5639 name: CC: presequence translocase-associated import motor | BP: | MF: def: "CC_def: Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.17224152612786 density:1 bootstrap:0.781876338 cc_score:0.264586 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7653 ! CC: | BP: | MF: relationship: linked_to NeXO:9102 ! CC: | BP: protein unfolding | MF: [Term] id: NeXO:7081 name: CC: | BP: | MF:ribonuclease T2 activity def: "CC_def: | BP_def: | MF_def:Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [NeXO-GO:term] namespace: NeXO comment: robustness:1.99741368251621 density:1 bootstrap:0.66108589 cc_score:0.0 bp_score:0.0875 mf_score:0.442357 relationship: child_of NeXO:7889 ! CC: | BP: | MF: relationship: linked_to NeXO:7150 ! CC: | BP: N-acylphosphatidylethanolamine metabolic process | MF:NAPE-specific phospholipase D activity [Term] id: NeXO:7080 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.80359048883235 density:0.0888888888888889 bootstrap:0.638669289 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9153 ! CC: | BP: | MF: [Term] id: NeXO:7083 name: CC: | BP: DNA-dependent transcriptional open complex formation | MF:TFIIIB-type transcription factor activity def: "CC_def: | BP_def: Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. | MF_def:Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [NeXO-GO:term] namespace: NeXO comment: robustness:6.59971186243233 density:0.571428571428571 bootstrap:0.7277419 cc_score:0.0 bp_score:0.149397 mf_score:0.177701 relationship: child_of NeXO:8833 ! CC: | BP: transcription initiation from RNA polymerase III promoter | MF:core RNA polymerase III binding transcription factor activity [Term] id: NeXO:7082 name: CC: site of double-strand break | BP: | MF: def: "CC_def: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.98529667915385 density:0.333333333333333 bootstrap:0.81189383 cc_score:0.150149 bp_score:0.0182151 mf_score:0.0 relationship: child_of NeXO:7634 ! CC: Smc5-Smc6 complex | BP: rDNA separation | MF: [Term] id: NeXO:7085 name: CC: EGO complex | BP: | MF:phosphatidylinositol-3,4-bisphosphate binding def: "CC_def: A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Meh1p, Gtr2p and Slm4p. | BP_def: | MF_def:Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [NeXO-GO:term] namespace: NeXO comment: robustness:2.79874644385095 density:0.333333333333333 bootstrap:0.83610728 cc_score:0.342725 bp_score:0.0 mf_score:0.157861 relationship: child_of NeXO:8625 ! CC: extrinsic to vacuolar membrane | BP: | MF: [Term] id: NeXO:8096 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.58317689218115 density:0.666666666666667 bootstrap:0.608108724 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8744 ! CC: | BP: | MF: relationship: linked_to NeXO:7517 ! CC: | BP: nuclear mRNA 5'-splice site recognition | MF: relationship: linked_to NeXO:9025 ! CC: | BP: mRNA splice site selection | MF:U1 snRNA binding relationship: linked_to NeXO:9385 ! CC: | BP: maturation of 5S rRNA | MF: [Term] id: NeXO:7087 name: CC: | BP: polyamine metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.67374621981304 density:0.155555555555556 bootstrap:0.289490692 cc_score:0.0 bp_score:0.2269 mf_score:0.0 relationship: child_of NeXO:7822 ! CC: | BP: arginine biosynthetic process | MF:carboxyl- or carbamoyltransferase activity [Term] id: NeXO:7086 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.05074720655917 density:0.0952380952380952 bootstrap:0.62274806 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8273 ! CC: | BP: | MF: [Term] id: NeXO:7089 name: CC: | BP: regulation of mRNA export from nucleus | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.366296874 cc_score:0.0 bp_score:0.22012 mf_score:0.0 relationship: child_of NeXO:7745 ! CC: | BP: | MF: [Term] id: NeXO:7088 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.54066551461415 density:0.166666666666667 bootstrap:0.558606484 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7534 ! CC: | BP: regulation of ribosomal protein gene transcription from RNA polymerase II promoter | MF: [Term] id: NeXO:9808 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.78964550832484 density:0.888888888888889 bootstrap:0.424114808 cc_score:0.0441509 bp_score:0.0526019 mf_score:0.0 relationship: child_of NeXO:10007 ! CC: preribosome | BP: rRNA processing | MF: relationship: linked_to NeXO:9689 ! CC: preribosome, small subunit precursor | BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: relationship: linked_to NeXO:9887 ! CC: small-subunit processome | BP: rRNA 5'-end processing | MF:snoRNA binding [Term] id: NeXO:5421 name: CC: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | BP: | MF:phosphatidylinositol N-acetylglucosaminyltransferase activity def: "CC_def: An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. | BP_def: | MF_def:Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [NeXO-GO:term] namespace: NeXO comment: robustness:4.14758588372372 density:1 bootstrap:0.95014296 cc_score:0.437866 bp_score:0.0 mf_score:0.539187 relationship: child_of NeXO:6380 ! CC: | BP: | MF:acetylglucosaminyltransferase activity [Term] id: NeXO:5420 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.83932665 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5741 ! CC: | BP: | MF: [Term] id: NeXO:5423 name: CC: | BP: histone demethylation | MF:histone demethylase activity (H3-K36 specific) def: "CC_def: | BP_def: The modification of histones by removal of methyl groups. | MF_def:Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.87586304 cc_score:0.0 bp_score:0.333828 mf_score:0.435197 relationship: child_of NeXO:7351 ! CC: | BP: | MF:histone demethylase activity [Term] id: NeXO:5422 name: CC: | BP: | MF:NEDD8 activating enzyme activity def: "CC_def: | BP_def: | MF_def:Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [NeXO-GO:term] namespace: NeXO comment: robustness:3.0684304035892 density:0.666666666666667 bootstrap:0.85803597 cc_score:0.0 bp_score:0.0 mf_score:0.575925 relationship: child_of NeXO:6549 ! CC: | BP: protein neddylation | MF:small protein activating enzyme activity [Term] id: NeXO:9807 name: CC: | BP: regulation of ER to Golgi vesicle-mediated transport | MF: def: "CC_def: | BP_def: Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.32047296068007 density:0.236363636363636 bootstrap:0.21812125 cc_score:0.0 bp_score:0.106045 mf_score:0.0736861 relationship: child_of NeXO:9971 ! CC: | BP: protein refolding | MF: [Term] id: NeXO:6461 name: CC: | BP: ion transmembrane transporter activity | MF:cystathionine beta-lyase activity def: "CC_def: | BP_def: Catalysis of the transfer of an ion from one side of a membrane to the other. | MF_def:Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [NeXO-GO:term] namespace: NeXO comment: robustness:2.90482353102372 density:0.666666666666667 bootstrap:0.768975402 cc_score:0.0 bp_score:0.229443 mf_score:0.166835 relationship: child_of NeXO:6524 ! CC: | BP: transsulfuration | MF:L-cysteine desulfhydrase activity [Term] id: NeXO:9010 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:8.65688326249161 density:0.857142857142857 bootstrap:0.73871072 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9728 ! CC: cytoplasmic microtubule | BP: microtubule-based movement | MF: relationship: linked_to NeXO:9668 ! CC: | BP: microtubule depolymerization | MF: [Term] id: NeXO:8540 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.16066926358504 density:0.111111111111111 bootstrap:0.287480146 cc_score:0.0 bp_score:0.0666321 mf_score:0.0887561 relationship: child_of NeXO:9391 ! CC: | BP: | MF: [Term] id: NeXO:7586 name: CC: HDA1 complex | BP: gene silencing involved in chronological cell aging | MF:NAD-dependent histone deacetylase activity (H3-K9 specific) def: "CC_def: A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p. | BP_def: Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation. | MF_def:Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [NeXO-GO:term] namespace: NeXO comment: robustness:3.73015798296759 density:1 bootstrap:0.7685155 cc_score:0.879216 bp_score:0.878527 mf_score:0.117538 relationship: child_of NeXO:8497 ! CC: | BP: gene silencing by RNA | MF:histone deacetylase activity (H3-K16 specific) [Term] id: NeXO:9011 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.8938866 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9375 ! CC: | BP: negative regulation of translation in response to stress | MF: [Term] id: NeXO:6495 name: CC: | BP: malate metabolic process | MF:L-malate dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. | MF_def:Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.62209386 cc_score:0.0 bp_score:0.341384 mf_score:0.4346 relationship: child_of NeXO:7225 ! CC: | BP: NADH regeneration | MF:malate dehydrogenase activity [Term] id: NeXO:8171 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.98495821504494 density:0.05 bootstrap:0.273134836 cc_score:0.0 bp_score:0.088785 mf_score:0.049485 relationship: child_of NeXO:9190 ! CC: | BP: | MF: [Term] id: NeXO:8172 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.79585238381462 density:0.666666666666667 bootstrap:0.7123631 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9067 ! CC: | BP: | MF: relationship: linked_to NeXO:6218 ! CC: | BP: | MF: [Term] id: NeXO:6496 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.496981941 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8698 ! CC: | BP: | MF: relationship: linked_to NeXO:6497 ! CC: | BP: | MF: [Term] id: NeXO:8174 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.872556647814738 density:0.0277777777777778 bootstrap:0.305382702 cc_score:0.0 bp_score:0.0 mf_score:0.0788606 relationship: child_of NeXO:8816 ! CC: | BP: | MF: [Term] id: NeXO:6490 name: CC: | BP: xylulose catabolic process | MF:xylulokinase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose. | MF_def:Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.736570101 cc_score:0.0 bp_score:0.307545 mf_score:0.4396 relationship: child_of NeXO:7044 ! CC: | BP: xylulose metabolic process | MF:D-xylulose reductase activity [Term] id: NeXO:6493 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.52784198 cc_score:0.0 bp_score:0.0 mf_score:0.0906117 relationship: child_of NeXO:6510 ! CC: | BP: glycerol catabolic process | MF:glycerone kinase activity [Term] id: NeXO:9132 name: CC: transcription factor TFIID complex | BP: | MF:sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly def: "CC_def: A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. | BP_def: | MF_def:Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:11.9089051864498 density:1 bootstrap:0.839218236 cc_score:0.412195 bp_score:0.0 mf_score:0.393138 relationship: child_of NeXO:9800 ! CC: SLIK (SAGA-like) complex | BP: histone acetylation | MF: [Term] id: NeXO:8178 name: CC: | BP: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) | MF:phosphoadenylyl-sulfate reductase (thioredoxin) activity def: "CC_def: | BP_def: The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). | MF_def:Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [NeXO-GO:term] namespace: NeXO comment: robustness:1.37890169294606 density:0.333333333333333 bootstrap:0.384986654 cc_score:0.0 bp_score:0.31767 mf_score:0.315681 relationship: child_of NeXO:8978 ! CC: | BP: cysteine biosynthetic process | MF:cysteine biosynthetic process relationship: linked_to NeXO:7223 ! CC: | BP: sulfate assimilation | MF:sulfate adenylyltransferase (ATP) activity [Term] id: NeXO:6464 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.67774924313586 density:0.5 bootstrap:0.88746694 cc_score:0.0 bp_score:0.0292402 mf_score:0.0 relationship: child_of NeXO:6465 ! CC: | BP: | MF: [Term] id: NeXO:9013 name: CC: | BP: | MF:5S rRNA binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [NeXO-GO:term] namespace: NeXO comment: robustness:1.43279062090751 density:1 bootstrap:0.340163183 cc_score:0.0 bp_score:0.0 mf_score:0.219688 relationship: child_of NeXO:9372 ! CC: | BP: | MF: relationship: linked_to NeXO:9291 ! CC: | BP: | MF: relationship: linked_to NeXO:9504 ! CC: Noc complex | BP: | MF: relationship: linked_to NeXO:8670 ! CC: | BP: negative regulation of histone H3-K36 methylation | MF: relationship: linked_to NeXO:8667 ! CC: | BP: | MF: relationship: linked_to NeXO:9550 ! CC: | BP: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | MF: [Term] id: NeXO:6499 name: CC: | BP: misfolded or incompletely synthesized protein catabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.49109181035684 density:0.1 bootstrap:0.593973807 cc_score:0.0 bp_score:0.130777 mf_score:0.0 relationship: child_of NeXO:7933 ! CC: | BP: | MF: [Term] id: NeXO:9131 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.56892093104715 density:0.380952380952381 bootstrap:0.352974274 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9876 ! CC: | BP: | MF: [Term] id: NeXO:9802 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.42779490896981 density:0.0097029702970297 bootstrap:0.171247762 cc_score:0.0 bp_score:0.0401771 mf_score:0.0395103 relationship: child_of NeXO:9932 ! CC: | BP: | MF: [Term] id: NeXO:5520 name: CC: | BP: oligopeptide export from mitochondrion | MF:oligopeptide-transporting ATPase activity def: "CC_def: | BP_def: The directed movement of oligopeptides out of mitochondria into the cytosol by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. | MF_def:Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89206288 cc_score:0.0 bp_score:0.293351 mf_score:0.297692 relationship: child_of NeXO:6039 ! CC: | BP: | MF: [Term] id: NeXO:5521 name: CC: | BP: mitochondrial DNA metabolic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways involving mitochondrial DNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.845723466 cc_score:0.0 bp_score:0.125997 mf_score:0.0 relationship: child_of NeXO:6976 ! CC: | BP: | MF: [Term] id: NeXO:5522 name: CC: | BP: regulation of sulfur amino acid metabolic process | MF:sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. | MF_def:Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II." [NeXO-GO:term] namespace: NeXO comment: robustness:2.33238005060502 density:1 bootstrap:0.90140608 cc_score:0.0 bp_score:0.444105 mf_score:0.257564 relationship: child_of NeXO:6989 ! CC: | BP: | MF:sequence-specific DNA binding transcription factor recruiting transcription factor activity [Term] id: NeXO:9130 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.92566043930819 density:0.5 bootstrap:0.52394675 cc_score:0.0 bp_score:0.0609206 mf_score:0.0 relationship: child_of NeXO:9588 ! CC: | BP: actin cortical patch assembly | MF: [Term] id: NeXO:5524 name: CC: | BP: positive regulation of transcription from RNA polymerase II promoter by pheromones | MF: def: "CC_def: | BP_def: Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.872073943 cc_score:0.0 bp_score:0.126725 mf_score:0.0 relationship: child_of NeXO:6017 ! CC: | BP: | MF: [Term] id: NeXO:5525 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.84586425 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5526 ! CC: | BP: regulation of TOR signaling cascade | MF: [Term] id: NeXO:5526 name: CC: | BP: regulation of TOR signaling cascade | MF: def: "CC_def: | BP_def: Any process that modulates the frequency, rate or extent of signaling via the TOR signaling pathway. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.13657594337851 density:0.333333333333333 bootstrap:0.924305917 cc_score:0.0 bp_score:0.426176 mf_score:0.0 relationship: child_of NeXO:7102 ! CC: extrinsic to fungal-type vacuolar membrane | BP: cellular response to amino acid starvation | MF: relationship: linked_to NeXO:8626 ! CC: GSE complex | BP: | MF: [Term] id: NeXO:5495 name: CC: | BP: NAD transport | MF:NAD transporter activity def: "CC_def: | BP_def: The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH. | MF_def:Enables the directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.924958273 cc_score:0.0 bp_score:0.294255 mf_score:0.295042 relationship: child_of NeXO:5721 ! CC: extrinsic to nuclear outer membrane | BP: nuclear membrane fusion involved in karyogamy | MF: [Term] id: NeXO:6943 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.77409833590404 density:0.333333333333333 bootstrap:0.641960838 cc_score:0.0 bp_score:0.0718017 mf_score:0.0 relationship: child_of NeXO:7623 ! CC: | BP: | MF: [Term] id: NeXO:6942 name: CC: clathrin adaptor complex | BP: | MF: def: "CC_def: A membrane coat adaptor complex that links clathrin to a membrane. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.10272689161709 density:0.25 bootstrap:0.594670947 cc_score:0.305511 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7865 ! CC: clathrin vesicle coat | BP: | MF: [Term] id: NeXO:6941 name: CC: clathrin coat of coated pit | BP: | MF: def: "CC_def: The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.73871943655902 density:0.6 bootstrap:0.7273806 cc_score:0.451283 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6942 ! CC: clathrin adaptor complex | BP: | MF: [Term] id: NeXO:6940 name: CC: | BP: fatty acid beta-oxidation | MF:intramolecular oxidoreductase activity, transposing C=C bonds def: "CC_def: | BP_def: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). | MF_def:Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [NeXO-GO:term] namespace: NeXO comment: robustness:2.36499993437367 density:0.2 bootstrap:0.465854225 cc_score:0.0 bp_score:0.160565 mf_score:0.204696 relationship: child_of NeXO:7212 ! CC: | BP: fatty acid catabolic process | MF: [Term] id: NeXO:6946 name: CC: | BP: leucine biosynthetic process | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.86890339037392 density:0.666666666666667 bootstrap:0.698282835 cc_score:0.0 bp_score:0.2472 mf_score:0.0 relationship: child_of NeXO:8316 ! CC: | BP: leucine metabolic process | MF: [Term] id: NeXO:6945 name: CC: | BP: threonine biosynthetic process | MF:threonine synthase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. | MF_def:Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:4.30334418805851 density:0.666666666666667 bootstrap:0.86390853 cc_score:0.0 bp_score:0.35552 mf_score:0.25599 relationship: child_of NeXO:8092 ! CC: | BP: threonine metabolic process | MF:O-phospho-L-serine:2-oxoglutarate aminotransferase activity [Term] id: NeXO:7295 name: CC: | BP: nuclear-transcribed mRNA catabolic process, no-go decay | MF: def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.59701483 cc_score:0.0 bp_score:0.201127 mf_score:0.0 relationship: child_of NeXO:8027 ! CC: gamma-tubulin small complex, spindle pole body | BP: | MF: [Term] id: NeXO:8094 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.52458656488459 density:0.333333333333333 bootstrap:0.470633938 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8882 ! CC: | BP: | MF: [Term] id: NeXO:9986 name: CC: spliceosomal complex | BP: RNA splicing, via transesterification reactions | MF: def: "CC_def: Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. | BP_def: Splicing of RNA via a series of two transesterification reactions. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.0078772919775 density:0.0893343007436967 bootstrap:0.267599768 cc_score:0.36176 bp_score:0.356129 mf_score:0.0333336 relationship: child_of NeXO:10009 ! CC: | BP: cellular localization | MF: [Term] id: NeXO:8510 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.46480676 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9102 ! CC: | BP: protein unfolding | MF: relationship: linked_to NeXO:6502 ! CC: integral to mitochondrial outer membrane | BP: tRNA import into mitochondrion | MF:mitochondrion targeting sequence binding [Term] id: NeXO:8699 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:11.1019340879072 density:0.139534883720930 bootstrap:0.307471935 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9544 ! CC: | BP: | MF: [Term] id: NeXO:7296 name: CC: | BP: positive regulation of phospholipid translocation | MF: def: "CC_def: | BP_def: Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49644419 cc_score:0.0 bp_score:0.314656 mf_score:0.0 relationship: child_of NeXO:8453 ! CC: | BP: protein autophosphorylation | MF: [Term] id: NeXO:5490 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.810572755 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6928 ! CC: | BP: | MF: [Term] id: NeXO:9134 name: CC: | BP: protein modification by small protein removal | MF: def: "CC_def: | BP_def: A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.13236030732294 density:0.208791208791209 bootstrap:0.242254535 cc_score:0.0 bp_score:0.102723 mf_score:0.0772735 relationship: child_of NeXO:9601 ! CC: | BP: | MF: [Term] id: NeXO:7469 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.37607407331096 density:1 bootstrap:0.313765704 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7765 ! CC: | BP: | MF: [Term] id: NeXO:7922 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.04137614726369 density:1 bootstrap:0.60475956 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8343 ! CC: | BP: | MF: relationship: linked_to NeXO:7742 ! CC: | BP: | MF: [Term] id: NeXO:8151 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:5.47699442026626 density:0.9 bootstrap:0.576698183 cc_score:0.0 bp_score:0.0 mf_score:0.0616292 relationship: child_of NeXO:8884 ! CC: | BP: | MF: [Term] id: NeXO:5493 name: CC: | BP: | MF:tRNA (guanine) methyltransferase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule." [NeXO-GO:term] namespace: NeXO comment: robustness:3.49682329922976 density:0.5 bootstrap:0.80899371 cc_score:0.0 bp_score:0.0802348 mf_score:0.166049 relationship: child_of NeXO:7582 ! CC: | BP: | MF: [Term] id: NeXO:7352 name: CC: RENT complex | BP: nucleolus organization | MF: def: "CC_def: A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit. | BP_def: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly the nucleolus. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.06120502149433 density:1 bootstrap:0.703986337 cc_score:0.178371 bp_score:0.58541 mf_score:0.0 relationship: child_of NeXO:8408 ! CC: | BP: | MF: relationship: linked_to NeXO:8741 ! CC: | BP: protein localization to nucleolar rDNA repeats | MF:rDNA spacer replication fork barrier binding [Term] id: NeXO:9203 name: CC: | BP: | MF:inositol hexakisphosphate 4-kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.138435744 cc_score:0.0 bp_score:0.0731078 mf_score:0.161443 relationship: child_of NeXO:9613 ! CC: | BP: | MF: [Term] id: NeXO:8698 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:20.0468955763313 density:0.686274509803922 bootstrap:0.74220108 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8699 ! CC: | BP: | MF: [Term] id: NeXO:8202 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.2101080167016 density:0.666666666666667 bootstrap:0.445143401 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8787 ! CC: | BP: | MF: [Term] id: NeXO:8399 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.638502443 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8778 ! CC: | BP: | MF: relationship: linked_to NeXO:6173 ! CC: | BP: tRNA 3'-trailer cleavage | MF: [Term] id: NeXO:8394 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.87353194617067 density:0.0571428571428571 bootstrap:0.230711682 cc_score:0.0 bp_score:0.0158149 mf_score:0.086449 relationship: child_of NeXO:9279 ! CC: | BP: | MF: [Term] id: NeXO:8395 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.03838638624411 density:0.090909090909091 bootstrap:0.230721635 cc_score:0.0 bp_score:0.0462924 mf_score:0.0 relationship: child_of NeXO:9143 ! CC: | BP: | MF: [Term] id: NeXO:8390 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.973153161173361 density:0.0256410256410256 bootstrap:0.226391871 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9283 ! CC: | BP: | MF: [Term] id: NeXO:8392 name: CC: Sec62/Sec63 complex | BP: retrograde protein transport, ER to cytosol | MF:peptide transporter activity def: "CC_def: A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p. | BP_def: The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. | MF_def:Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells." [NeXO-GO:term] namespace: NeXO comment: robustness:1.42974953394668 density:1 bootstrap:0.338720728 cc_score:0.190945 bp_score:0.438273 mf_score:0.101027 relationship: child_of NeXO:8760 ! CC: endoplasmic reticulum Sec complex | BP: posttranslational protein targeting to membrane, translocation | MF:P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: NeXO:8393 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:6.53698756524578 density:1 bootstrap:0.70805388 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8694 ! CC: U2 snRNP | BP: | MF: relationship: linked_to NeXO:9597 ! CC: U5 snRNP | BP: assembly of spliceosomal tri-snRNP | MF:U5 snRNA binding [Term] id: NeXO:8552 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.543144161 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9166 ! CC: | BP: | MF: [Term] id: NeXO:8488 name: CC: | BP: G-protein signaling, coupled to cAMP nucleotide second messenger | MF:adenylate cyclase activity def: "CC_def: | BP_def: The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP. | MF_def:Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:3.34520755902414 density:1 bootstrap:0.61807947 cc_score:0.0 bp_score:0.28869 mf_score:0.291993 relationship: child_of NeXO:9412 ! CC: | BP: cAMP-mediated signaling | MF: [Term] id: NeXO:8550 name: CC: | BP: positive regulation of transcription from RNA polymerase II promoter by galactose | MF: def: "CC_def: | BP_def: Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.55057552837267 density:1 bootstrap:0.69629887 cc_score:0.0 bp_score:0.357851 mf_score:0.0 relationship: child_of NeXO:9598 ! CC: | BP: positive regulation of transcription by galactose | MF: relationship: linked_to NeXO:7776 ! CC: | BP: | MF:TFIIH-class transcription factor binding [Term] id: NeXO:8551 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.37020464894252 density:1 bootstrap:0.62735119 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9383 ! CC: | BP: | MF: relationship: linked_to NeXO:7302 ! CC: | BP: | MF:TFIIH-class transcription factor recruiting transcription factor activity relationship: linked_to NeXO:7326 ! CC: | BP: | MF: relationship: linked_to NeXO:9672 ! CC: | BP: | MF: [Term] id: NeXO:8556 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.53963680243478 density:0.5 bootstrap:0.426718031 cc_score:0.0 bp_score:0.0920961 mf_score:0.0 relationship: child_of NeXO:9460 ! CC: | BP: gene conversion at mating-type locus, DNA double-strand break processing | MF:endodeoxyribonuclease activity [Term] id: NeXO:8557 name: CC: | BP: | MF:transcription from RNA polymerase III promoter def: "CC_def: | BP_def: | MF_def:The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [NeXO-GO:term] namespace: NeXO comment: robustness:5.74753800559875 density:1 bootstrap:0.91228024 cc_score:0.0 bp_score:0.0167787 mf_score:0.238462 relationship: child_of NeXO:9911 ! CC: nuclear DNA-directed RNA polymerase complex | BP: transcription from RNA polymerase III promoter | MF:DNA-directed RNA polymerase activity relationship: linked_to NeXO:8054 ! CC: | BP: | MF: relationship: linked_to NeXO:8610 ! CC: | BP: | MF: relationship: linked_to NeXO:8717 ! CC: | BP: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | MF: [Term] id: NeXO:9618 name: CC: commitment complex | BP: | MF: def: "CC_def: A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:14.7304406435873 density:0.403333333333333 bootstrap:0.408127975 cc_score:0.368997 bp_score:0.0517195 mf_score:0.0 relationship: child_of NeXO:9834 ! CC: U2-type precatalytic spliceosome | BP: | MF: [Term] id: NeXO:8555 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.40761391105143 density:0.5 bootstrap:0.383505378 cc_score:0.0 bp_score:0.0221606 mf_score:0.0 relationship: child_of NeXO:9214 ! CC: | BP: | MF: relationship: linked_to NeXO:8554 ! CC: MCM complex | BP: | MF: [Term] id: NeXO:8004 name: CC: | BP: | MF:potassium ion binding def: "CC_def: | BP_def: | MF_def:Interacting selectively and non-covalently with potassium (K+) ions." [NeXO-GO:term] namespace: NeXO comment: robustness:1.90388092126343 density:0.333333333333333 bootstrap:0.386914013 cc_score:0.0 bp_score:0.0303588 mf_score:0.383697 relationship: child_of NeXO:8657 ! CC: | BP: | MF:cAMP-dependent protein kinase regulator activity [Term] id: NeXO:8006 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.6575141563052 density:0.0879120879120879 bootstrap:0.303213155 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9143 ! CC: | BP: | MF: [Term] id: NeXO:8007 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.18642820205275 density:0.178571428571429 bootstrap:0.255289102 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8812 ! CC: | BP: | MF: [Term] id: NeXO:8000 name: CC: | BP: positive regulation of glycerol transport | MF:glutamate-tRNA ligase activity def: "CC_def: | BP_def: Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | MF_def:Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.68180101 cc_score:0.0 bp_score:0.294943 mf_score:0.292805 relationship: child_of NeXO:8739 ! CC: | BP: | MF:diphosphoinositol-pentakisphosphate kinase activity relationship: linked_to NeXO:9683 ! CC: | BP: MAP kinase activity | MF:MAP kinase activity [Term] id: NeXO:8001 name: CC: | BP: glycogen (starch) synthase activity | MF:glycogen (starch) synthase activity def: "CC_def: | BP_def: Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). | MF_def:Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [NeXO-GO:term] namespace: NeXO comment: robustness:5.04987796105678 density:0.466666666666667 bootstrap:0.76138986 cc_score:0.0 bp_score:0.300846 mf_score:0.307504 relationship: child_of NeXO:8366 ! CC: protein serine/threonine phosphatase complex | BP: glucan biosynthetic process | MF:protein phosphatase type 1 regulator activity [Term] id: NeXO:8002 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0.972655424548394 density:0.00529100529100529 bootstrap:0.64220907 cc_score:0.0 bp_score:0.0508965 mf_score:0.036839 relationship: child_of NeXO:9473 ! CC: | BP: | MF: [Term] id: NeXO:5257 name: CC: | BP: | MF:sphingosine-1-phosphate phosphatase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.88869005 cc_score:0.0 bp_score:0.0 mf_score:0.292091 relationship: child_of NeXO:5731 ! CC: cortical endoplasmic reticulum | BP: activation of protein kinase activity | MF:D-erythro-sphingosine kinase activity [Term] id: NeXO:6547 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.09718563022107 density:0.090909090909091 bootstrap:0.630555095 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7657 ! CC: | BP: | MF: [Term] id: NeXO:6546 name: CC: | BP: regulation of transcription, mating-type specific | MF: def: "CC_def: | BP_def: Any mating-type specific process that modulates the frequency, rate or extent of transcription. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:4.81231227651764 density:0.25 bootstrap:0.81816163 cc_score:0.0 bp_score:0.429545 mf_score:0.0 relationship: child_of NeXO:8222 ! CC: | BP: mating type determination | MF: [Term] id: NeXO:6545 name: CC: | BP: homoserine biosynthetic process | MF:aspartate-semialdehyde dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. | MF_def:Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [NeXO-GO:term] namespace: NeXO comment: robustness:2.99614520004025 density:0.666666666666667 bootstrap:0.81808542 cc_score:0.0 bp_score:0.428726 mf_score:0.314761 relationship: child_of NeXO:6945 ! CC: | BP: threonine biosynthetic process | MF:threonine synthase activity [Term] id: NeXO:5638 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.78823262 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:6773 ! CC: | BP: | MF: [Term] id: NeXO:6542 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.81670728 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:7593 ! CC: | BP: pyruvate metabolic process | MF:pyruvate kinase activity [Term] id: NeXO:9568 name: CC: | BP: Golgi vesicle docking | MF: def: "CC_def: | BP_def: The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:7.19414989712781 density:0.933333333333333 bootstrap:0.63280882 cc_score:0.0 bp_score:0.111403 mf_score:0.0 relationship: child_of NeXO:9718 ! CC: Golgi-associated vesicle membrane | BP: retrograde vesicle-mediated transport, Golgi to ER | MF: [Term] id: NeXO:6540 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.29570950665547 density:1 bootstrap:0.87328442 cc_score:0.0 bp_score:0.0 mf_score:0.0524526 relationship: child_of NeXO:6541 ! CC: | BP: | MF: [Term] id: NeXO:5634 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.511669569 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5699 ! CC: | BP: | MF:inositol heptakisphosphate 5-kinase activity [Term] id: NeXO:5635 name: CC: | BP: | MF:glucose 6-phosphate metabolic process def: "CC_def: | BP_def: | MF_def:The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.614392353 cc_score:0.0 bp_score:0.0 mf_score:0.132237 relationship: child_of NeXO:6193 ! CC: | BP: | MF: [Term] id: NeXO:5636 name: CC: | BP: | MF:Rho GDP-dissociation inhibitor activity def: "CC_def: | BP_def: | MF_def:Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.677872199 cc_score:0.0 bp_score:0.0310912 mf_score:0.299277 relationship: child_of NeXO:6085 ! CC: | BP: | MF: [Term] id: NeXO:5637 name: CC: | BP: positive regulation of histone ubiquitination | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.90209236 cc_score:0.0 bp_score:0.439741 mf_score:0.0 relationship: child_of NeXO:6854 ! CC: | BP: | MF: [Term] id: NeXO:5630 name: CC: chitosome | BP: | MF: def: "CC_def: An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.85561801 cc_score:0.29216 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5723 ! CC: | BP: | MF:chitin synthase activity [Term] id: NeXO:5631 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.89469259 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:5632 ! CC: | BP: | MF: [Term] id: NeXO:8160 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.66419999 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9067 ! CC: | BP: | MF: relationship: linked_to NeXO:7218 ! CC: | BP: positive regulation of mitochondrial DNA replication | MF: [Term] id: NeXO:6548 name: CC: | BP: peptide pheromone export | MF:peptide-transporting ATPase activity def: "CC_def: | BP_def: The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones. | MF_def:Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.49318146 cc_score:0.0 bp_score:0.438246 mf_score:0.232895 relationship: child_of NeXO:7160 ! CC: | BP: | MF: [Term] id: NeXO:8480 name: CC: | BP: | MF:phosphoglycerate kinase activity def: "CC_def: | BP_def: | MF_def:Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:1.44697671529799 density:1 bootstrap:0.346932457 cc_score:0.0 bp_score:0.0 mf_score:0.442589 relationship: child_of NeXO:8849 ! CC: | BP: | MF: [Term] id: NeXO:8481 name: CC: alpha DNA polymerase:primase complex | BP: DNA replication, synthesis of RNA primer | MF:DNA primase activity def: "CC_def: A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. | BP_def: The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. | MF_def:Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [NeXO-GO:term] namespace: NeXO comment: robustness:3.45027495001313 density:1 bootstrap:0.657514886 cc_score:0.380353 bp_score:0.440717 mf_score:0.586045 relationship: child_of NeXO:9156 ! CC: nuclear replisome | BP: DNA synthesis involved in DNA repair | MF: relationship: linked_to NeXO:9428 ! CC: | BP: DNA replication checkpoint | MF: [Term] id: NeXO:8482 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.80144955659031 density:0.333333333333333 bootstrap:0.657087607 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9220 ! CC: | BP: | MF: [Term] id: NeXO:7468 name: CC: | BP: urea catabolic process | MF:allophanate hydrolase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. | MF_def:Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [NeXO-GO:term] namespace: NeXO comment: robustness:3.59402410941752 density:1 bootstrap:0.71344443 cc_score:0.0 bp_score:0.224083 mf_score:0.293103 relationship: child_of NeXO:8345 ! CC: | BP: allantoin catabolic process | MF:urea carboxylase activity [Term] id: NeXO:8484 name: CC: | BP: positive regulation of translational elongation | MF: def: "CC_def: | BP_def: Any process that activates or increases the frequency, rate or extent of translational elongation. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.35029741578992 density:0.666666666666667 bootstrap:0.50340623 cc_score:0.0 bp_score:0.182318 mf_score:0.0 relationship: child_of NeXO:8900 ! CC: | BP: | MF:acid-ammonia (or amide) ligase activity [Term] id: NeXO:8485 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.9936011183178 density:0.2 bootstrap:0.265204322 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:9346 ! CC: | BP: | MF: [Term] id: NeXO:8486 name: CC: | BP: glutamine biosynthetic process | MF:glutamate dehydrogenase activity def: "CC_def: | BP_def: The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.14794858624501 density:0.333333333333333 bootstrap:0.266823416 cc_score:0.0 bp_score:0.269434 mf_score:0.273704 relationship: child_of NeXO:9194 ! CC: | BP: | MF: [Term] id: NeXO:8487 name: CC: | BP: nitrate assimilation | MF: def: "CC_def: | BP_def: The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.53470911487749 density:1 bootstrap:0.69008969 cc_score:0.0 bp_score:0.442241 mf_score:0.0 relationship: child_of NeXO:9553 ! CC: extrinsic to internal side of plasma membrane | BP: regulation of nitrogen utilization | MF: relationship: linked_to NeXO:8111 ! CC: | BP: nitrogen catabolite regulation of transcription | MF:gamma-aminobutyric acid:hydrogen symporter activity relationship: linked_to NeXO:8356 ! CC: TORC1 complex | BP: | MF: [Term] id: NeXO:7463 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.460701191 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8871 ! CC: | BP: positive regulation of protein import into nucleus | MF: relationship: linked_to NeXO:8628 ! CC: | BP: | MF: [Term] id: NeXO:8751 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.56101859765803 density:0.0363636363636364 bootstrap:0.502317148 cc_score:0.0 bp_score:0.0201673 mf_score:0.0 relationship: child_of NeXO:9652 ! CC: SCF ubiquitin ligase complex | BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | MF: [Term] id: NeXO:7461 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.7076965159421 density:0.1 bootstrap:0.779076149 cc_score:0.0 bp_score:0.055416 mf_score:0.0 relationship: child_of NeXO:8642 ! CC: eisosome | BP: | MF: [Term] id: NeXO:7460 name: CC: | BP: enzyme-directed rRNA pseudouridine synthesis | MF: def: "CC_def: | BP_def: The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:1.32197861761667 density:0.333333333333333 bootstrap:0.35385711 cc_score:0.0 bp_score:0.313819 mf_score:0.0 relationship: child_of NeXO:7692 ! CC: | BP: | MF: [Term] id: NeXO:7466 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:0 density:0 bootstrap:0.600927096 cc_score:0.0 bp_score:0.0 mf_score:0.0 relationship: child_of NeXO:8446 ! CC: | BP: | MF: relationship: linked_to NeXO:9314 ! CC: | BP: | MF: [Term] id: NeXO:7465 name: CC: dynactin complex | BP: establishment of mitotic spindle orientation | MF: def: "CC_def: A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. | BP_def: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:3.66569878153106 density:1 bootstrap:0.742184243 cc_score:0.535958 bp_score:0.219804 mf_score:0.0 relationship: child_of NeXO:8463 ! CC: astral microtubule | BP: | MF: relationship: linked_to NeXO:8883 ! CC: microtubule plus end | BP: nuclear migration along microtubule | MF:microtubule plus-end binding [Term] id: NeXO:7464 name: CC: | BP: | MF: def: "CC_def: | BP_def: | MF_def:" [NeXO-GO:term] namespace: NeXO comment: robustness:2.83974694273013 density:0.0666666666666667 bootstrap:0.433497498 cc_score:0.0 bp_score:0.0113402 mf_score:0.0 relationship: child_of NeXO:8385 ! CC: | BP: | MF: [Typedef] id: child_of name: child_of namespace: nexo is_transitive: true [Typedef] id: linked_to name: linked_to namespace: nexo is_transitive: true